locus-tag	class	description
ALEK_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ALEK_0002	COG0592	DNA-directed DNA polymerase activity
ALEK_0003	COG0187	DNA topoisomerase II activity
ALEK_0006	COG0492	ferredoxin-NADP+ reductase activity
ALEK_0007	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ALEK_0012	COG0564	pseudouridine synthase activity
ALEK_0013	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ALEK_0014	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ALEK_0015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ALEK_0027	COG0493	'glutamate synthase
ALEK_0034	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ALEK_0035	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ALEK_0038	COG2207	Transcriptional regulator
ALEK_0038	COG4753	response regulator
ALEK_0039	COG4191	Histidine kinase
ALEK_0041	COG0348	domain, Protein
ALEK_0042	COG1280	lysine exporter protein (LysE YggA)
ALEK_0046	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ALEK_0047	COG0604	alcohol dehydrogenase
ALEK_0048	COG1733	regulation of RNA biosynthetic process
ALEK_0049	COG0390	transport system, permease component
ALEK_0053	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ALEK_0054	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ALEK_0059	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ALEK_0060	COG1252	NADH dehydrogenase
ALEK_0061	COG2030	dehydratase
ALEK_0062	COG0659	secondary active sulfate transmembrane transporter activity
ALEK_0063	COG1960	acyl-CoA dehydrogenase activity
ALEK_0064	COG2181	nitrate reductase activity
ALEK_0064	COG0247	lactate metabolic process
ALEK_0065	COG2086	electron transfer activity
ALEK_0066	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ALEK_0067	COG0500	methyltransferase
ALEK_0068	COG1250	3-hydroxyacyl-CoA dehydrogenase
ALEK_0069	COG2050	protein possibly involved in aromatic compounds catabolism
ALEK_0070	COG0824	Thioesterase
ALEK_0071	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ALEK_0073	COG0183	Belongs to the thiolase family
ALEK_0074	COG5002	protein histidine kinase activity
ALEK_0076	COG0745	RESPONSE REGULATOR receiver
ALEK_0077	COG4191	Histidine kinase
ALEK_0078	COG1556	Lactate utilization protein
ALEK_0079	COG1139	Iron-sulfur cluster binding protein
ALEK_0080	COG0247	lactate metabolic process
ALEK_0082	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ALEK_0082	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ALEK_0084	COG0439	Biotin carboxylase
ALEK_0085	COG0513	Belongs to the DEAD box helicase family
ALEK_0087	COG0306	phosphate transporter
ALEK_0088	COG0745	RESPONSE REGULATOR receiver
ALEK_0090	COG0367	asparagine synthase
ALEK_0092	COG0778	Nitroreductase
ALEK_0093	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ALEK_0094	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ALEK_0095	COG1053	succinate dehydrogenase
ALEK_0097	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ALEK_0099	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ALEK_0099	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ALEK_0100	COG1187	pseudouridine synthase activity
ALEK_0101	COG0517	IMP dehydrogenase activity
ALEK_0101	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ALEK_0103	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ALEK_0104	COG0107	imidazoleglycerol-phosphate synthase activity
ALEK_0107	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ALEK_0108	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ALEK_0109	COG0724	RNA recognition motif
ALEK_0110	COG0840	transmembrane signaling receptor activity
ALEK_0111	COG0745	RESPONSE REGULATOR receiver
ALEK_0112	COG0642	Histidine kinase
ALEK_0116	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ALEK_0118	COG3220	belongs to the UPF0276 family
ALEK_0120	COG0534	Mate efflux family protein
ALEK_0121	COG0460	homoserine dehydrogenase
ALEK_0122	COG0436	Aminotransferase
ALEK_0125	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ALEK_0126	COG0254	rRNA binding
ALEK_0127	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ALEK_0130	COG2199	diguanylate cyclase activity
ALEK_0133	COG0840	transmembrane signaling receptor activity
ALEK_0134	COG3706	GGDEF domain
ALEK_0135	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ALEK_0137	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ALEK_0138	COG0237	dephospho-CoA kinase activity
ALEK_0139	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ALEK_0140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ALEK_0141	COG0840	transmembrane signaling receptor activity
ALEK_0142	COG2814	Major facilitator Superfamily
ALEK_0143	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ALEK_0144	COG1741	Belongs to the pirin family
ALEK_0146	COG0431	NADPH-dependent FMN reductase
ALEK_0147	COG2353	YceI-like domain
ALEK_0149	COG1280	lysine exporter protein (LysE YggA)
ALEK_0150	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ALEK_0151	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ALEK_0152	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ALEK_0154	COG0505	Belongs to the CarA family
ALEK_0156	COG1733	regulation of RNA biosynthetic process
ALEK_0159	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ALEK_0159	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ALEK_0161	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ALEK_0163	COG3901	Regulator of nitric oxide reductase transcription
ALEK_0163	COG0348	domain, Protein
ALEK_0164	COG0489	protein tyrosine kinase activity
ALEK_0165	COG2249	NAD(P)H dehydrogenase (quinone) activity
ALEK_0168	COG0140	phosphoribosyl-ATP diphosphatase activity
ALEK_0168	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ALEK_0174	COG2315	Protein conserved in bacteria
ALEK_0175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ALEK_0176	COG1121	(ABC) transporter
ALEK_0178	COG0646	methionine synthase
ALEK_0178	COG1410	methionine synthase
ALEK_0183	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ALEK_0186	COG4773	Receptor
ALEK_0187	COG1979	alcohol dehydrogenase
ALEK_0188	COG2207	Transcriptional regulator
ALEK_0189	COG1979	alcohol dehydrogenase
ALEK_0190	COG2207	Transcriptional regulator
ALEK_0191	COG0243	molybdopterin cofactor binding
ALEK_0193	COG0745	RESPONSE REGULATOR receiver
ALEK_0198	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ALEK_0199	COG0405	Gamma-glutamyltransferase
ALEK_0204	COG1854	S-ribosylhomocysteine lyase activity
ALEK_0206	COG2200	EAL domain
ALEK_0207	COG3180	Ammonia monooxygenase
ALEK_0209	COG0288	reversible hydration of carbon dioxide
ALEK_0211	COG0745	RESPONSE REGULATOR receiver
ALEK_0215	COG1733	regulation of RNA biosynthetic process
ALEK_0216	COG2249	NAD(P)H dehydrogenase (quinone) activity
ALEK_0217	COG1013	pyruvate-flavodoxin oxidoreductase activity
ALEK_0218	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_0218	COG0674	pyruvate-flavodoxin oxidoreductase activity
ALEK_0218	COG1013	pyruvate-flavodoxin oxidoreductase activity
ALEK_0218	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ALEK_0220	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ALEK_0221	COG0546	phosphoglycolate phosphatase activity
ALEK_0223	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ALEK_0224	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ALEK_0225	COG5002	protein histidine kinase activity
ALEK_0226	COG0745	RESPONSE REGULATOR receiver
ALEK_0228	COG0704	Plays a role in the regulation of phosphate uptake
ALEK_0229	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ALEK_0230	COG0581	inorganic phosphate transmembrane transporter activity
ALEK_0231	COG0573	inorganic phosphate transmembrane transporter activity
ALEK_0232	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ALEK_0235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ALEK_0236	COG0268	Binds directly to 16S ribosomal RNA
ALEK_0237	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ALEK_0238	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ALEK_0239	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ALEK_0243	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ALEK_0244	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ALEK_0245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ALEK_0254	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ALEK_0258	COG0300	oxidoreductase activity
ALEK_0258	COG0318	PFAM AMP-dependent synthetase and ligase
ALEK_0258	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ALEK_0258	COG1028	Short-chain dehydrogenase reductase Sdr
ALEK_0258	COG3321	synthase
ALEK_0261	COG1131	(ABC) transporter
ALEK_0266	COG1028	Short-chain dehydrogenase reductase Sdr
ALEK_0267	COG2986	histidine ammonia-lyase
ALEK_0271	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ALEK_0272	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ALEK_0277	COG0575	Belongs to the CDS family
ALEK_0278	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ALEK_0282	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ALEK_0284	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ALEK_0284	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ALEK_0285	COG1324	tolerance protein
ALEK_0286	COG2022	thiamine diphosphate biosynthetic process
ALEK_0305	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ALEK_0311	COG0793	Belongs to the peptidase S41A family
ALEK_0312	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ALEK_0313	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ALEK_0314	COG0047	phosphoribosylformylglycinamidine synthase activity
ALEK_0316	COG0204	Acyl-transferase
ALEK_0317	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ALEK_0318	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ALEK_0319	COG0018	arginyl-trna synthetase
ALEK_0321	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ALEK_0322	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ALEK_0323	COG0126	phosphoglycerate kinase activity
ALEK_0324	COG0149	triose-phosphate isomerase activity
ALEK_0325	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ALEK_0326	COG0019	diaminopimelate decarboxylase activity
ALEK_0327	COG0077	Prephenate dehydratase
ALEK_0327	COG1605	Chorismate mutase
ALEK_0328	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ALEK_0329	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ALEK_0331	COG0778	Nitroreductase
ALEK_0336	COG1012	belongs to the aldehyde dehydrogenase family
ALEK_0338	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ALEK_0340	COG0243	molybdopterin cofactor binding
ALEK_0343	COG1802	Transcriptional regulator
ALEK_0344	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ALEK_0346	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ALEK_0347	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ALEK_0349	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ALEK_0352	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ALEK_0353	COG1845	cytochrome c oxidase, subunit III
ALEK_0355	COG0424	maF-like protein
ALEK_0357	COG1605	Chorismate mutase
ALEK_0357	COG0077	Prephenate dehydratase
ALEK_0358	COG0473	3-isopropylmalate dehydrogenase activity
ALEK_0359	COG1028	Short-chain dehydrogenase reductase Sdr
ALEK_0363	COG0398	Pfam SNARE associated Golgi protein
ALEK_0365	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ALEK_0368	COG0745	RESPONSE REGULATOR receiver
ALEK_0376	COG0730	response to heat
ALEK_0382	COG4569	acetaldehyde dehydrogenase (acetylating) activity
ALEK_0386	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ALEK_0387	COG2267	carboxylic ester hydrolase activity
ALEK_0391	COG0791	NLP P60 protein
ALEK_0392	COG0791	NLP P60 protein
ALEK_0396	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ALEK_0397	COG3118	belongs to the thioredoxin family
ALEK_0398	COG3118	belongs to the thioredoxin family
ALEK_0400	COG4191	Histidine kinase
ALEK_0401	COG0745	RESPONSE REGULATOR receiver
ALEK_0402	COG1115	amino acid carrier protein
ALEK_0403	COG0492	ferredoxin-NADP+ reductase activity
ALEK_0404	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ALEK_0405	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ALEK_0406	COG1242	4 iron, 4 sulfur cluster binding
ALEK_0408	COG0210	DNA helicase
ALEK_0409	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ALEK_0410	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ALEK_0411	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ALEK_0412	COG3278	Belongs to the heme-copper respiratory oxidase family
ALEK_0421	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ALEK_0425	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ALEK_0427	COG0157	Belongs to the NadC ModD family
ALEK_0430	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ALEK_0432	COG0083	homoserine kinase activity
ALEK_0434	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ALEK_0435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ALEK_0436	COG0779	Required for maturation of 30S ribosomal subunits
ALEK_0438	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ALEK_0439	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ALEK_0440	COG0539	negative regulation of cytoplasmic translation
ALEK_0440	COG1185	polyribonucleotide nucleotidyltransferase activity
ALEK_0441	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ALEK_0442	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ALEK_0443	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALEK_0443	COG0072	phenylalanine-tRNA ligase activity
ALEK_0444	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ALEK_0445	COG0537	adenosine 5'-monophosphoramidase activity
ALEK_0446	COG0825	malonyl-CoA metabolic process
ALEK_0447	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ALEK_0448	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ALEK_0450	COG0602	queuosine metabolic process
ALEK_0452	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ALEK_0455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ALEK_0458	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ALEK_0460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ALEK_0461	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ALEK_0462	COG3706	GGDEF domain
ALEK_0463	COG1074	ATP-dependent DNA helicase activity
ALEK_0465	COG0356	it plays a direct role in the translocation of protons across the membrane
ALEK_0466	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ALEK_0467	COG0336	Belongs to the RNA methyltransferase TrmD family
ALEK_0468	COG0335	large ribosomal subunit rRNA binding
ALEK_0470	COG0586	Pfam SNARE associated Golgi protein
ALEK_0472	COG1119	ATPase activity
ALEK_0474	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ALEK_0476	COG2423	ornithine cyclodeaminase activity
ALEK_0477	COG3938	Belongs to the proline racemase family
ALEK_0478	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ALEK_0479	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_0480	COG4215	(ABC) transporter
ALEK_0481	COG0765	amino acid transport
ALEK_0482	COG1126	abc transporter atp-binding protein
ALEK_0483	COG4948	Mandelate Racemase Muconate Lactonizing
ALEK_0494	COG0410	ABC transporter
ALEK_0495	COG1012	belongs to the aldehyde dehydrogenase family
ALEK_0497	COG0840	transmembrane signaling receptor activity
ALEK_0505	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ALEK_0509	COG2885	chlorophyll binding
ALEK_0511	COG0745	RESPONSE REGULATOR receiver
ALEK_0517	COG2197	response regulator
ALEK_0521	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ALEK_0526	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ALEK_0526	COG1648	precorrin-2 dehydrogenase activity
ALEK_0528	COG0535	radical SAM domain protein
ALEK_0535	COG3256	nitric oxide reductase
ALEK_0538	COG4753	response regulator
ALEK_0538	COG2207	Transcriptional regulator
ALEK_0541	COG4773	Receptor
ALEK_0542	COG5002	protein histidine kinase activity
ALEK_0554	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ALEK_0555	COG0848	biopolymer transport protein
ALEK_0556	COG0811	peptide transport
ALEK_0557	COG0811	peptide transport
ALEK_0561	COG4774	siderophore transport
ALEK_0561	COG1629	transport
ALEK_0562	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ALEK_0565	COG0604	alcohol dehydrogenase
ALEK_0572	COG3043	anaerobic respiration
ALEK_0573	COG0348	domain, Protein
ALEK_0574	COG0437	4 iron, 4 sulfur cluster binding
ALEK_0575	COG0243	molybdopterin cofactor binding
ALEK_0577	COG1648	precorrin-2 dehydrogenase activity
ALEK_0577	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ALEK_0580	COG1760	l-serine dehydratase
ALEK_0581	COG1126	abc transporter atp-binding protein
ALEK_0582	COG0765	amino acid transport
ALEK_0583	COG4597	amino acid ABC transporter
ALEK_0584	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_0585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ALEK_0585	COG1648	precorrin-2 dehydrogenase activity
ALEK_0588	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ALEK_0589	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ALEK_0590	COG3287	FIST C domain
ALEK_0590	COG2199	diguanylate cyclase activity
ALEK_0590	COG2200	EAL domain
ALEK_0593	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ALEK_0595	COG2404	hydrolase activity, acting on ester bonds
ALEK_0596	COG1832	CoA-binding protein
ALEK_0597	COG0642	Histidine kinase
ALEK_0598	COG0745	RESPONSE REGULATOR receiver
ALEK_0599	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ALEK_0600	COG0191	fructose-bisphosphate aldolase activity
ALEK_0603	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ALEK_0607	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ALEK_0615	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ALEK_0618	COG0535	radical SAM domain protein
ALEK_0620	COG0745	RESPONSE REGULATOR receiver
ALEK_0621	COG0784	Response regulator, receiver
ALEK_0621	COG2205	protein histidine kinase activity
ALEK_0621	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_0621	COG2198	Histidine kinase
ALEK_0622	COG1012	belongs to the aldehyde dehydrogenase family
ALEK_0624	COG0848	biopolymer transport protein
ALEK_0625	COG0811	peptide transport
ALEK_0628	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ALEK_0629	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ALEK_0631	COG0142	geranyltranstransferase activity
ALEK_0632	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ALEK_0633	COG0442	prolyl-tRNA aminoacylation
ALEK_0634	COG0668	transmembrane transport
ALEK_0635	COG0617	tRNA 3'-terminal CCA addition
ALEK_0636	COG0668	transmembrane transport
ALEK_0637	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ALEK_0638	COG1862	Preprotein translocase
ALEK_0639	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ALEK_0640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ALEK_0645	COG0495	leucyl-tRNA aminoacylation
ALEK_0647	COG0285	dihydrofolate synthase activity
ALEK_0648	COG0739	heme binding
ALEK_0650	COG0513	Belongs to the DEAD box helicase family
ALEK_0653	COG0745	RESPONSE REGULATOR receiver
ALEK_0663	COG4399	Belongs to the UPF0754 family
ALEK_0664	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ALEK_0668	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ALEK_0668	COG0140	phosphoribosyl-ATP diphosphatase activity
ALEK_0669	COG0418	dihydroorotase activity
ALEK_0670	COG0745	RESPONSE REGULATOR receiver
ALEK_0671	COG5002	protein histidine kinase activity
ALEK_0673	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ALEK_0674	COG2816	NAD+ diphosphatase activity
ALEK_0677	COG2081	HI0933 family
ALEK_0679	COG2203	Gaf domain
ALEK_0679	COG5001	Diguanylate cyclase
ALEK_0679	COG4251	negative regulation of phosphorylation
ALEK_0679	COG3706	GGDEF domain
ALEK_0682	COG1999	signal sequence binding
ALEK_0684	COG0745	RESPONSE REGULATOR receiver
ALEK_0685	COG0642	Histidine kinase
ALEK_0686	COG2081	HI0933 family
ALEK_0687	COG1692	metallophosphoesterase
ALEK_0691	COG2226	methyltransferase
ALEK_0692	COG1570	exodeoxyribonuclease VII activity
ALEK_0693	COG0835	chemotaxis
ALEK_0694	COG0745	RESPONSE REGULATOR receiver
ALEK_0696	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ALEK_0698	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ALEK_0699	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ALEK_0701	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ALEK_0702	COG0459	protein refolding
ALEK_0704	COG2207	Transcriptional regulator
ALEK_0707	COG2201	protein-glutamate methylesterase activity
ALEK_0710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ALEK_0711	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ALEK_0712	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ALEK_0713	COG0352	thiamine-phosphate diphosphorylase activity
ALEK_0714	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ALEK_0717	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ALEK_0718	COG2264	protein methyltransferase activity
ALEK_0719	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ALEK_0721	COG3706	GGDEF domain
ALEK_0721	COG4251	negative regulation of phosphorylation
ALEK_0721	COG5001	Diguanylate cyclase
ALEK_0721	COG2203	Gaf domain
ALEK_0722	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ALEK_0726	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ALEK_0730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ALEK_0732	COG1090	epimerase
ALEK_0733	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ALEK_0735	COG3437	response regulator, receiver
ALEK_0735	COG0784	Response regulator, receiver
ALEK_0737	COG0481	GTPase activity
ALEK_0738	COG2885	chlorophyll binding
ALEK_0741	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ALEK_0742	COG0482	sulfurtransferase activity
ALEK_0743	COG0482	sulfurtransferase activity
ALEK_0744	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ALEK_0745	COG0006	proline dipeptidase activity
ALEK_0746	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ALEK_0747	COG0402	S-adenosylhomocysteine deaminase activity
ALEK_0748	COG0616	signal peptide processing
ALEK_0749	COG0513	Belongs to the DEAD box helicase family
ALEK_0751	COG0280	phosphate acetyltransferase
ALEK_0752	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ALEK_0753	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ALEK_0757	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ALEK_0761	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ALEK_0763	COG0745	RESPONSE REGULATOR receiver
ALEK_0764	COG5002	protein histidine kinase activity
ALEK_0785	COG1546	Belongs to the CinA family
ALEK_0785	COG1058	Belongs to the CinA family
ALEK_0786	COG0579	oxidoreductase
ALEK_0787	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ALEK_0791	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ALEK_0796	COG0714	Associated with various cellular activities
ALEK_0798	COG0745	RESPONSE REGULATOR receiver
ALEK_0801	COG0052	Belongs to the universal ribosomal protein uS2 family
ALEK_0802	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ALEK_0803	COG1136	(ABC) transporter
ALEK_0805	COG0194	GDP metabolic process
ALEK_0806	COG5002	protein histidine kinase activity
ALEK_0806	COG5001	Diguanylate cyclase
ALEK_0807	COG2217	Heavy metal translocating P-type atpase
ALEK_0811	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ALEK_0813	COG1355	regulation of microtubule-based process
ALEK_0814	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ALEK_0815	COG1121	(ABC) transporter
ALEK_0816	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ALEK_0817	COG2996	Protein conserved in bacteria
ALEK_0818	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ALEK_0820	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ALEK_0821	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ALEK_0822	COG0210	DNA helicase
ALEK_0824	COG0525	valine-tRNA ligase activity
ALEK_0826	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ALEK_0829	COG2814	Major facilitator Superfamily
ALEK_0830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ALEK_0834	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ALEK_0835	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ALEK_0836	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ALEK_0839	COG2207	Transcriptional regulator
ALEK_0839	COG1917	Cupin 2, conserved barrel domain protein
ALEK_0845	COG0840	transmembrane signaling receptor activity
ALEK_0846	COG0668	transmembrane transport
ALEK_0854	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ALEK_0855	COG0840	transmembrane signaling receptor activity
ALEK_0861	COG1858	cytochrome C peroxidase
ALEK_0863	COG1028	Short-chain dehydrogenase reductase Sdr
ALEK_0865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ALEK_0868	COG1301	dicarboxylic acid transport
ALEK_0871	COG1917	Cupin 2, conserved barrel domain protein
ALEK_0871	COG2207	Transcriptional regulator
ALEK_0872	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ALEK_0877	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ALEK_0881	COG0626	cystathionine gamma-synthase activity
ALEK_0889	COG0585	pseudouridine synthase activity
ALEK_0891	COG3118	belongs to the thioredoxin family
ALEK_0892	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ALEK_0901	COG0432	Pfam Uncharacterised protein family UPF0047
ALEK_0907	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ALEK_0908	COG2056	Na+-H+ antiporter family
ALEK_0910	COG2199	diguanylate cyclase activity
ALEK_0910	COG2200	EAL domain
ALEK_0910	COG3287	FIST C domain
ALEK_0911	COG2151	metal-sulfur cluster biosynthetic enzyme
ALEK_0912	COG2166	iron-sulfur cluster assembly
ALEK_0913	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ALEK_0915	COG0396	ATPase activity
ALEK_0916	COG0719	Fe-S assembly protein
ALEK_0917	COG0765	amino acid transport
ALEK_0919	COG1104	cysteine desulfurase activity
ALEK_0925	COG0165	Argininosuccinate lyase
ALEK_0926	COG0835	chemotaxis
ALEK_0926	COG0784	Response regulator, receiver
ALEK_0927	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ALEK_0928	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ALEK_0929	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ALEK_0932	COG0556	nucleotide-excision repair
ALEK_0933	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ALEK_0934	COG1234	tRNA 3'-trailer cleavage
ALEK_0938	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ALEK_0942	COG0698	ribose 5-phosphate isomerase
ALEK_0943	COG0681	Belongs to the peptidase S26 family
ALEK_0944	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ALEK_0945	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ALEK_0946	COG0193	aminoacyl-tRNA hydrolase activity
ALEK_0949	COG0860	N-Acetylmuramoyl-L-alanine amidase
ALEK_0951	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ALEK_0953	COG1758	RNA polymerase activity
ALEK_0954	COG0528	UMP kinase activity
ALEK_0956	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ALEK_0957	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ALEK_0958	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ALEK_0960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ALEK_0961	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ALEK_0963	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ALEK_0964	COG0305	Participates in initiation and elongation during chromosome replication
ALEK_0966	COG1793	dna ligase
ALEK_0973	COG0166	Belongs to the GPI family
ALEK_0974	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ALEK_0975	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ALEK_0977	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ALEK_0978	COG2089	acid synthase
ALEK_0980	COG0107	imidazoleglycerol-phosphate synthase activity
ALEK_0986	COG2089	acid synthase
ALEK_0987	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ALEK_0993	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ALEK_1003	COG1063	alcohol dehydrogenase
ALEK_1006	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ALEK_1010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ALEK_1011	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ALEK_1012	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ALEK_1013	COG0133	tryptophan synthase activity
ALEK_1015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ALEK_1016	COG0243	molybdopterin cofactor binding
ALEK_1017	COG3043	anaerobic respiration
ALEK_1018	COG3043	anaerobic respiration
ALEK_1020	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ALEK_1021	COG0732	type I restriction modification DNA specificity domain
ALEK_1026	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ALEK_1041	COG0012	GTP binding
ALEK_1046	COG3123	guanosine phosphorylase activity
ALEK_1049	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ALEK_1050	COG0585	pseudouridine synthase activity
ALEK_1052	COG0840	transmembrane signaling receptor activity
ALEK_1053	COG0632	four-way junction helicase activity
ALEK_1054	COG1181	Belongs to the D-alanine--D-alanine ligase family
ALEK_1056	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ALEK_1069	COG2207	Transcriptional regulator
ALEK_1071	COG0051	transcription antitermination factor activity, RNA binding
ALEK_1072	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ALEK_1073	COG0088	Forms part of the polypeptide exit tunnel
ALEK_1074	COG0089	rRNA binding
ALEK_1075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ALEK_1076	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ALEK_1077	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ALEK_1078	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ALEK_1079	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ALEK_1080	COG0255	Belongs to the universal ribosomal protein uL29 family
ALEK_1081	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ALEK_1082	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ALEK_1083	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ALEK_1084	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ALEK_1085	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ALEK_1086	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ALEK_1087	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ALEK_1088	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ALEK_1089	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ALEK_1090	COG0200	Binds to the 23S rRNA
ALEK_1091	COG0201	protein transport
ALEK_1092	COG0024	Methionine aminopeptidase
ALEK_1093	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ALEK_1095	COG1573	uracil-dna glycosylase
ALEK_1097	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ALEK_1100	COG1032	radical SAM domain protein
ALEK_1101	COG0563	adenylate kinase activity
ALEK_1102	COG0840	transmembrane signaling receptor activity
ALEK_1105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ALEK_1106	COG0322	excinuclease ABC activity
ALEK_1111	COG0386	Belongs to the glutathione peroxidase family
ALEK_1112	COG3706	GGDEF domain
ALEK_1117	COG1620	l-lactate permease
ALEK_1119	COG3852	Histidine kinase
ALEK_1126	COG0840	transmembrane signaling receptor activity
ALEK_1126	COG0840	transmembrane signaling receptor activity
ALEK_1129	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ALEK_1130	COG1472	Belongs to the glycosyl hydrolase 3 family
ALEK_1136	COG0708	Exodeoxyribonuclease III
ALEK_1137	COG1309	transcriptional regulator
ALEK_1145	COG2271	Major facilitator Superfamily
ALEK_1150	COG0745	RESPONSE REGULATOR receiver
ALEK_1160	COG0579	oxidoreductase
ALEK_1161	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ALEK_1162	COG2169	Transcriptional regulator
ALEK_1162	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ALEK_1164	COG1115	amino acid carrier protein
ALEK_1167	COG0745	RESPONSE REGULATOR receiver
ALEK_1168	COG1027	Aspartate ammonia-lyase
ALEK_1170	COG1528	Iron-storage protein
ALEK_1172	COG4191	Histidine kinase
ALEK_1172	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_1174	COG5001	Diguanylate cyclase
ALEK_1174	COG3300	MHYT domain
ALEK_1176	COG1227	inorganic diphosphatase activity
ALEK_1178	COG4335	DNA alkylation repair
ALEK_1179	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ALEK_1185	COG2995	paraquat-inducible protein a
ALEK_1186	COG3008	intermembrane lipid transfer
ALEK_1187	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ALEK_1188	COG4175	Glycine betaine
ALEK_1189	COG4176	ABC-type proline glycine betaine transport system permease component
ALEK_1190	COG2113	Glycine betaine
ALEK_1192	COG2113	Glycine betaine
ALEK_1194	COG1509	lysine 2,3-aminomutase activity
ALEK_1197	COG0702	epimerase
ALEK_1200	COG0326	Molecular chaperone. Has ATPase activity
ALEK_1205	COG0583	DNA-binding transcription factor activity
ALEK_1209	COG0840	transmembrane signaling receptor activity
ALEK_1210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ALEK_1212	COG0840	transmembrane signaling receptor activity
ALEK_1221	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ALEK_1222	COG0745	RESPONSE REGULATOR receiver
ALEK_1226	COG0840	transmembrane signaling receptor activity
ALEK_1229	COG0745	RESPONSE REGULATOR receiver
ALEK_1230	COG0642	Histidine kinase
ALEK_1231	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ALEK_1236	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALEK_1241	COG1611	Belongs to the LOG family
ALEK_1243	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ALEK_1244	COG4753	response regulator
ALEK_1244	COG2207	Transcriptional regulator
ALEK_1245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ALEK_1249	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ALEK_1251	COG1984	allophanate hydrolase subunit 2
ALEK_1253	COG3287	FIST C domain
ALEK_1253	COG2200	EAL domain
ALEK_1253	COG2199	diguanylate cyclase activity
ALEK_1256	COG0840	transmembrane signaling receptor activity
ALEK_1257	COG0513	Belongs to the DEAD box helicase family
ALEK_1259	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ALEK_1261	COG4771	TonB-dependent receptor
ALEK_1262	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ALEK_1263	COG1116	anion transmembrane transporter activity
ALEK_1268	COG4771	TonB-dependent receptor
ALEK_1269	COG0784	Response regulator, receiver
ALEK_1271	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ALEK_1273	COG0840	transmembrane signaling receptor activity
ALEK_1274	COG0259	pyridoxamine-phosphate oxidase activity
ALEK_1275	COG3287	FIST C domain
ALEK_1275	COG2199	diguanylate cyclase activity
ALEK_1275	COG2200	EAL domain
ALEK_1277	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ALEK_1279	COG2201	protein-glutamate methylesterase activity
ALEK_1281	COG2199	diguanylate cyclase activity
ALEK_1281	COG3287	FIST C domain
ALEK_1281	COG2200	EAL domain
ALEK_1282	COG0745	RESPONSE REGULATOR receiver
ALEK_1284	COG0110	maltose O-acetyltransferase activity
ALEK_1285	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ALEK_1287	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ALEK_1290	COG2205	protein histidine kinase activity
ALEK_1290	COG5002	protein histidine kinase activity
ALEK_1290	COG0784	Response regulator, receiver
ALEK_1305	COG1921	L-seryl-tRNASec selenium transferase activity
ALEK_1310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_1310	COG4191	Histidine kinase
ALEK_1311	COG0784	Response regulator, receiver
ALEK_1311	COG3437	response regulator, receiver
ALEK_1312	COG4191	Histidine kinase
ALEK_1312	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_1313	COG0784	Response regulator, receiver
ALEK_1313	COG3437	response regulator, receiver
ALEK_1314	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ALEK_1315	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ALEK_1316	COG3639	organic phosphonate transmembrane transporter activity
ALEK_1320	COG2204	response regulator
ALEK_1327	COG0437	4 iron, 4 sulfur cluster binding
ALEK_1329	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ALEK_1334	COG2998	abc-type tungstate transport system, permease component
ALEK_1335	COG4662	Binding-protein-dependent transport system inner membrane component
ALEK_1337	COG3041	Addiction module toxin RelE StbE family
ALEK_1338	COG3077	Addiction module antitoxin, RelB DinJ family
ALEK_1347	COG1187	pseudouridine synthase activity
ALEK_1350	COG4232	protein-disulfide reductase activity
ALEK_1363	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ALEK_1370	COG0251	oxidation-reduction process
ALEK_1371	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ALEK_1372	COG1115	amino acid carrier protein
ALEK_1373	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ALEK_1374	COG1280	lysine exporter protein (LysE YggA)
ALEK_1379	COG0745	RESPONSE REGULATOR receiver
ALEK_1381	COG0328	RNA-DNA hybrid ribonuclease activity
ALEK_1388	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ALEK_1394	COG0716	FMN binding
ALEK_1396	COG2201	protein-glutamate methylesterase activity
ALEK_1399	COG0784	Response regulator, receiver
ALEK_1399	COG0835	chemotaxis
ALEK_1400	COG0835	chemotaxis
ALEK_1401	COG0840	transmembrane signaling receptor activity
ALEK_1402	COG0840	transmembrane signaling receptor activity
ALEK_1403	COG0643	Histidine kinase
ALEK_1403	COG2198	Histidine kinase
ALEK_1405	COG2201	protein-glutamate methylesterase activity
ALEK_1406	COG0745	RESPONSE REGULATOR receiver
ALEK_1409	COG2204	response regulator
ALEK_1410	COG2199	diguanylate cyclase activity
ALEK_1410	COG3287	FIST C domain
ALEK_1410	COG2200	EAL domain
ALEK_1413	COG2204	response regulator
ALEK_1422	COG3706	GGDEF domain
ALEK_1424	COG2885	chlorophyll binding
ALEK_1425	COG0693	protein deglycase activity
ALEK_1426	COG1414	Transcriptional regulator
ALEK_1429	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ALEK_1433	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ALEK_1434	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ALEK_1434	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ALEK_1439	COG0436	Aminotransferase
ALEK_1441	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ALEK_1446	COG2853	Lipoprotein
ALEK_1447	COG0739	heme binding
ALEK_1448	COG1067	ATP-dependent peptidase activity
ALEK_1449	COG1027	Aspartate ammonia-lyase
ALEK_1450	COG0217	transcriptional regulatory protein
ALEK_1459	COG1477	protein flavinylation
ALEK_1460	COG4783	chaperone-mediated protein folding
ALEK_1463	COG1250	3-hydroxyacyl-CoA dehydrogenase
ALEK_1463	COG1024	Enoyl-CoA hydratase
ALEK_1464	COG0183	Belongs to the thiolase family
ALEK_1465	COG1022	Amp-dependent synthetase and ligase
ALEK_1466	COG0697	spore germination
ALEK_1468	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ALEK_1469	COG0242	peptide deformylase activity
ALEK_1470	COG0114	fumarate hydratase activity
ALEK_1473	COG1012	belongs to the aldehyde dehydrogenase family
ALEK_1478	COG1049	propionate catabolic process, 2-methylcitrate cycle
ALEK_1480	COG0564	pseudouridine synthase activity
ALEK_1485	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ALEK_1486	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ALEK_1492	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ALEK_1493	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ALEK_1494	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ALEK_1495	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
ALEK_1496	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ALEK_1497	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ALEK_1498	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ALEK_1500	COG0778	Nitroreductase
ALEK_1507	COG0733	neurotransmitter:sodium symporter activity
ALEK_1508	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ALEK_1509	COG2894	cell division
ALEK_1510	COG0850	regulation of cytokinetic process
ALEK_1511	COG0513	Belongs to the DEAD box helicase family
ALEK_1514	COG1858	cytochrome C peroxidase
ALEK_1515	COG0300	oxidoreductase activity
ALEK_1517	COG0300	oxidoreductase activity
ALEK_1519	COG2814	Major facilitator Superfamily
ALEK_1521	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_1521	COG4191	Histidine kinase
ALEK_1524	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ALEK_1529	COG0840	transmembrane signaling receptor activity
ALEK_1530	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ALEK_1531	COG0298	carbon dioxide binding
ALEK_1532	COG0409	Hydrogenase expression formation protein
ALEK_1533	COG0309	Hydrogenase expression formation protein (HypE)
ALEK_1534	COG1024	Enoyl-CoA hydratase
ALEK_1534	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ALEK_1535	COG0375	protein maturation
ALEK_1543	COG2095	MarC family integral membrane protein
ALEK_1548	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ALEK_1550	COG0330	HflC and HflK could
ALEK_1551	COG2171	N-acyltransferase activity
ALEK_1553	COG0488	(ABC) transporter
ALEK_1555	COG2076	Multidrug Resistance protein
ALEK_1558	COG1584	GPR1 FUN34 yaaH family protein
ALEK_1561	COG2884	Cell division ATP-binding protein ftsE
ALEK_1562	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ALEK_1564	COG0564	pseudouridine synthase activity
ALEK_1565	COG0772	Belongs to the SEDS family
ALEK_1566	COG0010	Belongs to the arginase family
ALEK_1570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ALEK_1571	COG3123	guanosine phosphorylase activity
ALEK_1575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ALEK_1576	COG0066	3-isopropylmalate dehydratase activity
ALEK_1577	COG0473	3-isopropylmalate dehydrogenase activity
ALEK_1580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ALEK_1581	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ALEK_1582	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ALEK_1583	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ALEK_1584	COG0202	RNA polymerase activity
ALEK_1585	COG0203	ribosomal protein L17
ALEK_1586	COG0154	amidase activity
ALEK_1587	COG0517	IMP dehydrogenase activity
ALEK_1587	COG0516	GMP reductase activity
ALEK_1596	COG0563	adenylate kinase activity
ALEK_1601	COG1047	Peptidyl-prolyl cis-trans
ALEK_1605	COG1047	Peptidyl-prolyl cis-trans
ALEK_1607	COG2391	methyltransferase activity
ALEK_1610	COG1280	lysine exporter protein (LysE YggA)
ALEK_1611	COG1280	lysine exporter protein (LysE YggA)
ALEK_1614	COG4772	TonB-dependent receptor
ALEK_1618	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ALEK_1620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ALEK_1622	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ALEK_1623	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ALEK_1628	COG2274	protein secretion by the type I secretion system
ALEK_1638	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ALEK_1640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALEK_1641	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ALEK_1643	COG0521	Mo-molybdopterin cofactor biosynthetic process
ALEK_1644	COG0471	metal ion transport
ALEK_1645	COG1193	negative regulation of DNA recombination
ALEK_1649	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ALEK_1652	COG0456	acetyltransferase
ALEK_1653	COG1742	UPF0060 membrane protein
ALEK_1656	COG4977	sequence-specific DNA binding
ALEK_1658	COG2824	Alkylphosphonate utilization operon protein PhnA
ALEK_1660	COG1119	ATPase activity
ALEK_1664	COG2207	Transcriptional regulator
ALEK_1664	COG1609	Transcriptional regulator
ALEK_1665	COG1881	PFAM PEBP family protein
ALEK_1671	COG1794	racemase activity, acting on amino acids and derivatives
ALEK_1672	COG0583	DNA-binding transcription factor activity
ALEK_1673	COG2855	membrane
ALEK_1676	COG1733	regulation of RNA biosynthetic process
ALEK_1677	COG2249	NAD(P)H dehydrogenase (quinone) activity
ALEK_1679	COG0778	Nitroreductase
ALEK_1681	COG2197	response regulator
ALEK_1684	COG0840	transmembrane signaling receptor activity
ALEK_1685	COG3842	ATPase activity
ALEK_1696	COG5002	protein histidine kinase activity
ALEK_1698	COG0010	Belongs to the arginase family
ALEK_1700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ALEK_1700	COG0301	tRNA thio-modification
ALEK_1703	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ALEK_1705	COG0488	(ABC) transporter
ALEK_1706	COG1607	acyl-coa hydrolase
ALEK_1708	COG2205	protein histidine kinase activity
ALEK_1708	COG5002	protein histidine kinase activity
ALEK_1708	COG0784	Response regulator, receiver
ALEK_1709	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ALEK_1719	COG2195	Cleaves the N-terminal amino acid of tripeptides
ALEK_1720	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ALEK_1728	COG0745	RESPONSE REGULATOR receiver
ALEK_1729	COG2205	protein histidine kinase activity
ALEK_1729	COG4191	Histidine kinase
ALEK_1729	COG0745	RESPONSE REGULATOR receiver
ALEK_1732	COG4221	oxidoreductase activity
ALEK_1733	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ALEK_1733	COG1333	cytochrome c biogenesis protein
ALEK_1734	COG0500	methyltransferase
ALEK_1735	COG5001	Diguanylate cyclase
ALEK_1735	COG2203	Gaf domain
ALEK_1735	COG4251	negative regulation of phosphorylation
ALEK_1735	COG3706	GGDEF domain
ALEK_1736	COG3706	GGDEF domain
ALEK_1737	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ALEK_1739	COG2188	Transcriptional regulator
ALEK_1740	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ALEK_1742	COG3639	organic phosphonate transmembrane transporter activity
ALEK_1746	COG3627	carbon phosphorus lyase activity
ALEK_1747	COG4107	phosphonate C-P lyase system protein PhnK
ALEK_1748	COG4778	phosphonate C-P lyase system protein PhnL
ALEK_1749	COG3454	Phosphonate metabolism
ALEK_1752	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ALEK_1752	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ALEK_1755	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ALEK_1758	COG3040	lipid binding
ALEK_1761	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ALEK_1764	COG3040	lipid binding
ALEK_1765	COG2211	Major facilitator Superfamily
ALEK_1767	COG0300	oxidoreductase activity
ALEK_1771	COG2274	protein secretion by the type I secretion system
ALEK_1775	COG0133	tryptophan synthase activity
ALEK_1776	COG4191	Histidine kinase
ALEK_1777	COG0484	heat shock protein binding
ALEK_1778	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ALEK_1779	COG0840	transmembrane signaling receptor activity
ALEK_1780	COG0840	transmembrane signaling receptor activity
ALEK_1783	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ALEK_1786	COG0189	ligase activity
ALEK_1788	COG0137	argininosuccinate synthase activity
ALEK_1790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ALEK_1791	COG0802	atpase or kinase
ALEK_1792	COG1137	ATPase activity
ALEK_1793	COG3706	GGDEF domain
ALEK_1794	COG2200	EAL domain
ALEK_1794	COG3287	FIST C domain
ALEK_1794	COG2199	diguanylate cyclase activity
ALEK_1795	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ALEK_1796	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ALEK_1796	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ALEK_1800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ALEK_1801	COG2181	nitrate reductase activity
ALEK_1801	COG0247	lactate metabolic process
ALEK_1802	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ALEK_1803	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ALEK_1804	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ALEK_1804	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ALEK_1807	COG0745	RESPONSE REGULATOR receiver
ALEK_1808	COG0840	transmembrane signaling receptor activity
ALEK_1809	COG0113	porphobilinogen synthase activity
ALEK_1810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ALEK_1811	COG0357	Ribosomal RNA small subunit methyltransferase G
ALEK_1827	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ALEK_1828	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ALEK_1833	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALEK_1833	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALEK_1835	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ALEK_1837	COG2356	endonuclease I
ALEK_1841	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ALEK_1842	COG0612	Peptidase, M16
ALEK_1843	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ALEK_1844	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ALEK_1846	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ALEK_1849	COG0527	aspartate kinase activity
ALEK_1850	COG0494	nUDIX hydrolase
ALEK_1851	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ALEK_1852	COG2890	protein-(glutamine-N5) methyltransferase activity
ALEK_1853	COG0339	signal peptide processing
ALEK_1856	COG0582	viral genome integration into host DNA
ALEK_1857	COG2201	protein-glutamate methylesterase activity
ALEK_1859	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ALEK_1860	COG0643	Histidine kinase
ALEK_1860	COG2198	Histidine kinase
ALEK_1862	COG1185	polyribonucleotide nucleotidyltransferase activity
ALEK_1864	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ALEK_1868	COG0659	secondary active sulfate transmembrane transporter activity
ALEK_1869	COG1160	GTP binding
ALEK_1871	COG1674	ftsk spoiiie
ALEK_1871	COG1196	nuclear chromosome segregation
ALEK_1872	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALEK_1873	COG0440	acetolactate synthase activity
ALEK_1874	COG0028	Belongs to the TPP enzyme family
ALEK_1877	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ALEK_1878	COG4251	negative regulation of phosphorylation
ALEK_1878	COG2203	Gaf domain
ALEK_1878	COG5001	Diguanylate cyclase
ALEK_1878	COG3706	GGDEF domain
ALEK_1880	COG0659	secondary active sulfate transmembrane transporter activity
ALEK_1885	COG0037	tRNA processing
ALEK_1888	COG0303	'Molybdopterin
ALEK_1889	COG3706	GGDEF domain
ALEK_1889	COG4251	negative regulation of phosphorylation
ALEK_1889	COG2203	Gaf domain
ALEK_1889	COG5001	Diguanylate cyclase
ALEK_1891	COG1322	Protein conserved in bacteria
ALEK_1892	COG0501	Belongs to the peptidase M48B family
ALEK_1893	COG3706	GGDEF domain
ALEK_1895	COG0824	Thioesterase
ALEK_1903	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ALEK_1904	COG4172	Belongs to the ABC transporter superfamily
ALEK_1905	COG0534	Mate efflux family protein
ALEK_1907	COG0840	transmembrane signaling receptor activity
ALEK_1908	COG0840	transmembrane signaling receptor activity
ALEK_1909	COG0667	Aldo Keto reductase
ALEK_1915	COG1797	cobyrinic acid a,c-diamide synthase activity
ALEK_1927	COG2226	methyltransferase
ALEK_1932	COG2207	Transcriptional regulator
ALEK_1933	COG2226	methyltransferase
ALEK_1935	COG1122	ATPase activity
ALEK_1940	COG0546	phosphoglycolate phosphatase activity
ALEK_1942	COG0330	HflC and HflK could
ALEK_1944	COG0745	RESPONSE REGULATOR receiver
ALEK_1946	COG0788	formyltetrahydrofolate deformylase activity
ALEK_1947	COG0469	pyruvate kinase activity
ALEK_1948	COG1012	belongs to the aldehyde dehydrogenase family
ALEK_1949	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ALEK_1952	COG0395	ABC-type sugar transport system, permease component
ALEK_1956	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ALEK_1957	COG2188	Transcriptional regulator
ALEK_1958	COG2188	Transcriptional regulator
ALEK_1959	COG0280	phosphate acetyltransferase
ALEK_1959	COG0281	malic enzyme
ALEK_1960	COG1027	Aspartate ammonia-lyase
ALEK_1961	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ALEK_1962	COG3852	Histidine kinase
ALEK_1963	COG0745	RESPONSE REGULATOR receiver
ALEK_1967	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ALEK_1971	COG3681	Belongs to the UPF0597 family
ALEK_1972	COG0583	DNA-binding transcription factor activity
ALEK_1974	COG2239	Acts as a magnesium transporter
ALEK_1977	COG0754	glutathionylspermidine amidase activity
ALEK_1984	COG0672	)-iron permease
ALEK_1985	COG0010	Belongs to the arginase family
ALEK_1986	COG1228	amidohydrolase
ALEK_1987	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ALEK_1988	COG2986	histidine ammonia-lyase
ALEK_1989	COG2188	Transcriptional regulator
ALEK_1996	COG1663	tetraacyldisaccharide 4'-kinase activity
ALEK_1998	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ALEK_2003	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ALEK_2004	COG0805	protein transport
ALEK_2005	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ALEK_2011	COG0733	neurotransmitter:sodium symporter activity
ALEK_2015	COG1929	Belongs to the glycerate kinase type-1 family
ALEK_2016	COG3011	Protein conserved in bacteria
ALEK_2019	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ALEK_2023	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ALEK_2026	COG0745	RESPONSE REGULATOR receiver
ALEK_2028	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ALEK_2036	COG3813	Protein conserved in bacteria
ALEK_2038	COG4991	sh3 domain protein
ALEK_2041	COG0745	RESPONSE REGULATOR receiver
ALEK_2042	COG3850	Histidine kinase
ALEK_2042	COG5002	protein histidine kinase activity
ALEK_2043	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ALEK_2044	COG4269	membrane
ALEK_2045	COG0501	Belongs to the peptidase M48B family
ALEK_2046	COG0419	ATPase involved in DNA repair
ALEK_2048	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ALEK_2048	COG2199	diguanylate cyclase activity
ALEK_2050	COG2205	protein histidine kinase activity
ALEK_2051	COG0840	transmembrane signaling receptor activity
ALEK_2057	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ALEK_2060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ALEK_2061	COG1073	alpha beta
ALEK_2064	COG2203	Gaf domain
ALEK_2064	COG2199	diguanylate cyclase activity
ALEK_2066	COG4865	methylaspartate mutase activity
ALEK_2068	COG0318	PFAM AMP-dependent synthetase and ligase
ALEK_2074	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ALEK_2078	COG0275	rRNA processing
ALEK_2080	COG0776	regulation of translation
ALEK_2083	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ALEK_2085	COG3279	Response regulator of the LytR AlgR family
ALEK_2086	COG3275	phosphorelay sensor kinase activity
ALEK_2087	COG1233	COG1233 Phytoene dehydrogenase and related
ALEK_2089	COG3272	Protein of unknown function (DUF1722)
ALEK_2090	COG1643	Atp-dependent helicase
ALEK_2092	COG1283	sodium-dependent phosphate transmembrane transporter activity
ALEK_2096	COG4977	sequence-specific DNA binding
ALEK_2096	COG1917	Cupin 2, conserved barrel domain protein
ALEK_2098	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ALEK_2098	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ALEK_2101	COG0642	Histidine kinase
ALEK_2108	COG1132	(ABC) transporter
ALEK_2110	COG0628	permease
ALEK_2113	COG1280	lysine exporter protein (LysE YggA)
ALEK_2115	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ALEK_2116	COG0653	protein targeting
ALEK_2117	COG4591	ABC-type transport system involved in lipoprotein release permease component
ALEK_2118	COG4191	Histidine kinase
ALEK_2118	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_2120	COG0784	Response regulator, receiver
ALEK_2120	COG3437	response regulator, receiver
ALEK_2124	COG0039	L-malate dehydrogenase activity
ALEK_2126	COG1230	cation diffusion facilitator family transporter
ALEK_2129	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ALEK_2129	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ALEK_2131	COG0484	heat shock protein binding
ALEK_2132	COG0789	Transcriptional regulator
ALEK_2133	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ALEK_2134	COG0849	cell division
ALEK_2136	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ALEK_2141	COG4783	chaperone-mediated protein folding
ALEK_2145	COG0768	penicillin binding
ALEK_2147	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ALEK_2148	COG1338	Plays a role in the flagellum-specific transport system
ALEK_2149	COG1047	Peptidyl-prolyl cis-trans
ALEK_2155	COG2205	protein histidine kinase activity
ALEK_2156	COG0747	negative chemotaxis
ALEK_2157	COG0601	transmembrane transport
ALEK_2158	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ALEK_2159	COG0444	Belongs to the ABC transporter superfamily
ALEK_2160	COG4608	Belongs to the ABC transporter superfamily
ALEK_2165	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ALEK_2168	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ALEK_2169	COG0131	Imidazoleglycerol-phosphate dehydratase
ALEK_2170	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ALEK_2171	COG0084	hydrolase, TatD family'
ALEK_2173	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ALEK_2174	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ALEK_2175	COG0359	binds to the 23S rRNA
ALEK_2176	COG0642	Histidine kinase
ALEK_2177	COG0745	RESPONSE REGULATOR receiver
ALEK_2180	COG0163	prenyltransferase activity
ALEK_2181	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ALEK_2182	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ALEK_2183	COG0124	histidyl-tRNA synthetase
ALEK_2184	COG1166	arginine decarboxylase activity
ALEK_2185	COG1045	serine acetyltransferase
ALEK_2188	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ALEK_2192	COG0753	catalase activity
ALEK_2193	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ALEK_2197	COG4536	flavin adenine dinucleotide binding
ALEK_2198	COG3338	carbonate dehydratase activity
ALEK_2199	COG0748	coenzyme F420 binding
ALEK_2202	COG0628	permease
ALEK_2208	COG3287	FIST C domain
ALEK_2208	COG2199	diguanylate cyclase activity
ALEK_2208	COG2200	EAL domain
ALEK_2209	COG1028	Short-chain dehydrogenase reductase Sdr
ALEK_2210	COG2346	COG2346, Truncated hemoglobins
ALEK_2212	COG2223	nitrite transmembrane transporter activity
ALEK_2213	COG0205	6-phosphofructokinase activity
ALEK_2214	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ALEK_2216	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ALEK_2217	COG2199	diguanylate cyclase activity
ALEK_2217	COG2203	Gaf domain
ALEK_2219	COG4565	transcriptional regulatory protein
ALEK_2221	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ALEK_2223	COG1917	Cupin 2, conserved barrel domain protein
ALEK_2223	COG2207	Transcriptional regulator
ALEK_2224	COG3708	Transcriptional regulator
ALEK_2224	COG2207	Transcriptional regulator
ALEK_2228	COG1489	DNA binding
ALEK_2231	COG1917	Cupin 2, conserved barrel domain protein
ALEK_2231	COG2207	Transcriptional regulator
ALEK_2233	COG1253	flavin adenine dinucleotide binding
ALEK_2237	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ALEK_2242	COG0251	oxidation-reduction process
ALEK_2243	COG2860	membrane
ALEK_2245	COG3437	response regulator, receiver
ALEK_2245	COG2205	protein histidine kinase activity
ALEK_2245	COG4999	Histidine kinase
ALEK_2245	COG3850	Histidine kinase
ALEK_2246	COG1231	oxidoreductase activity
ALEK_2247	COG3852	Histidine kinase
ALEK_2252	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ALEK_2254	COG2010	Cytochrome c
ALEK_2255	COG3256	nitric oxide reductase
ALEK_2258	COG0716	FMN binding
ALEK_2260	COG2133	pyrroloquinoline quinone binding
ALEK_2262	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ALEK_2268	COG0596	Alpha beta hydrolase
ALEK_2270	COG2207	Transcriptional regulator
ALEK_2271	COG2249	NAD(P)H dehydrogenase (quinone) activity
ALEK_2273	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ALEK_2274	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ALEK_2275	COG1794	racemase activity, acting on amino acids and derivatives
ALEK_2287	COG2831	hemolysin activation secretion protein
ALEK_2288	COG0745	RESPONSE REGULATOR receiver
ALEK_2289	COG3852	Histidine kinase
ALEK_2290	COG4753	response regulator
ALEK_2290	COG2207	Transcriptional regulator
ALEK_2300	COG1773	rubredoxin
ALEK_2304	COG1187	pseudouridine synthase activity
ALEK_2312	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ALEK_2316	COG0251	oxidation-reduction process
ALEK_2320	COG0519	Catalyzes the synthesis of GMP from XMP
ALEK_2320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ALEK_2322	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ALEK_2323	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ALEK_2326	COG1451	nucleotide metabolic process
ALEK_2328	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ALEK_2336	COG0745	RESPONSE REGULATOR receiver
ALEK_2337	COG0745	RESPONSE REGULATOR receiver
ALEK_2338	COG2202	Pas domain
ALEK_2338	COG2205	protein histidine kinase activity
ALEK_2341	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ALEK_2347	COG0438	transferase activity, transferring glycosyl groups
ALEK_2349	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ALEK_2350	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ALEK_2350	COG0662	Cupin 2, conserved barrel domain protein
ALEK_2359	COG1045	serine acetyltransferase
ALEK_2366	COG1610	YqeY-like protein
ALEK_2367	COG3706	GGDEF domain
ALEK_2370	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ALEK_2378	COG1902	pentaerythritol trinitrate reductase activity
ALEK_2380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ALEK_2382	COG0840	transmembrane signaling receptor activity
ALEK_2385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ALEK_2387	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ALEK_2391	COG5000	phosphorelay sensor kinase activity
ALEK_2397	COG0745	RESPONSE REGULATOR receiver
ALEK_2398	COG0642	Histidine kinase
ALEK_2400	COG0488	(ABC) transporter
ALEK_2403	COG2226	methyltransferase
ALEK_2405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ALEK_2407	COG0784	Response regulator, receiver
ALEK_2407	COG4191	Histidine kinase
ALEK_2409	COG2207	Transcriptional regulator
ALEK_2417	COG0300	oxidoreductase activity
ALEK_2418	COG1757	Na H antiporter
ALEK_2421	COG2207	Transcriptional regulator
ALEK_2421	COG4753	response regulator
ALEK_2424	COG1566	PFAM secretion protein HlyD family protein
ALEK_2427	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ALEK_2428	COG0742	ribosomal rna small subunit methyltransferase
ALEK_2430	COG1418	mRNA catabolic process
ALEK_2432	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALEK_2433	COG0552	protein localization to endoplasmic reticulum
ALEK_2434	COG1280	lysine exporter protein (LysE YggA)
ALEK_2436	COG0745	RESPONSE REGULATOR receiver
ALEK_2437	COG5002	protein histidine kinase activity
ALEK_2438	COG3258	Cytochrome c
ALEK_2439	COG3150	esterase
ALEK_2441	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ALEK_2443	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ALEK_2446	COG1592	Rubrerythrin
ALEK_2447	COG1592	Rubrerythrin
ALEK_2449	COG0728	peptidoglycan biosynthetic process
ALEK_2451	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ALEK_2452	COG1845	cytochrome c oxidase, subunit III
ALEK_2455	COG0109	protoheme IX farnesyltransferase activity
ALEK_2456	COG1132	(ABC) transporter
ALEK_2457	COG0167	dihydroorotate dehydrogenase activity
ALEK_2460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ALEK_2461	COG1028	Short-chain dehydrogenase reductase Sdr
ALEK_2462	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ALEK_2463	COG0750	zinc metalloprotease
ALEK_2464	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ALEK_2465	COG1942	4-Oxalocrotonate Tautomerase
ALEK_2468	COG0583	DNA-binding transcription factor activity
ALEK_2469	COG4191	Histidine kinase
ALEK_2470	COG0134	indole-3-glycerol-phosphate synthase activity
ALEK_2472	COG0727	PFAM Uncharacterised protein family (UPF0153)
ALEK_2473	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ALEK_2475	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ALEK_2475	COG0674	pyruvate-flavodoxin oxidoreductase activity
ALEK_2476	COG1013	pyruvate-flavodoxin oxidoreductase activity
ALEK_2478	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ALEK_2479	COG2176	DNA-directed DNA polymerase activity
ALEK_2480	COG0135	phosphoribosylanthranilate isomerase activity
ALEK_2481	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ALEK_2482	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ALEK_2484	COG0494	nUDIX hydrolase
ALEK_2485	COG0642	Histidine kinase
ALEK_2486	COG0745	RESPONSE REGULATOR receiver
ALEK_2488	COG1666	GTP binding
ALEK_2489	COG2233	PERMEase
ALEK_2490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ALEK_2493	COG2363	Small membrane protein
ALEK_2495	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ALEK_2496	COG2252	PERMEase
ALEK_2499	COG2151	metal-sulfur cluster biosynthetic enzyme
ALEK_2500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ALEK_2501	COG2207	Transcriptional regulator
ALEK_2501	COG4753	response regulator
ALEK_2515	COG0731	radical SAM domain protein
ALEK_2516	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ALEK_2518	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ALEK_2521	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ALEK_2522	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ALEK_2523	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ALEK_2526	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ALEK_2528	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ALEK_2528	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ALEK_2529	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ALEK_2530	COG0859	PFAM glycosyl transferase family 9
ALEK_2531	COG0438	transferase activity, transferring glycosyl groups
ALEK_2533	COG0859	PFAM glycosyl transferase family 9
ALEK_2535	COG0438	transferase activity, transferring glycosyl groups
ALEK_2540	COG1088	dTDP-glucose 4,6-dehydratase activity
ALEK_2541	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ALEK_2545	COG0859	PFAM glycosyl transferase family 9
ALEK_2547	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ALEK_2549	COG0493	'glutamate synthase
ALEK_2550	COG0070	glutamate synthase
ALEK_2550	COG0067	glutamate synthase
ALEK_2550	COG0069	glutamate synthase activity
ALEK_2558	COG1136	(ABC) transporter
ALEK_2565	COG3278	Belongs to the heme-copper respiratory oxidase family
ALEK_2585	COG2197	response regulator
ALEK_2597	COG2204	response regulator
ALEK_2615	COG0284	orotidine-5'-phosphate decarboxylase activity
ALEK_2616	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ALEK_2617	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ALEK_2618	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ALEK_2621	COG0069	glutamate synthase activity
ALEK_2623	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ALEK_2629	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ALEK_2630	COG1450	Type ii and iii secretion system protein
ALEK_2639	COG1739	Uncharacterized protein family UPF0029
ALEK_2642	COG2226	methyltransferase
ALEK_2643	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ALEK_2645	COG0277	FAD linked oxidase domain protein
ALEK_2654	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ALEK_2655	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ALEK_2656	COG1047	Peptidyl-prolyl cis-trans
ALEK_2659	COG0823	Involved in the tonB-independent uptake of proteins
ALEK_2661	COG0848	biopolymer transport protein
ALEK_2662	COG0811	peptide transport
ALEK_2663	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ALEK_2664	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ALEK_2665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ALEK_2666	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ALEK_2667	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ALEK_2668	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ALEK_2670	COG1475	DNA binding
ALEK_2671	COG1192	Involved in chromosome partitioning
ALEK_2674	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ALEK_2675	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ALEK_2676	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ALEK_2677	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ALEK_2678	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ALEK_2679	COG0251	oxidation-reduction process
ALEK_2680	COG0358	DNA primase activity
ALEK_2682	COG0571	ribonuclease III activity
ALEK_2683	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ALEK_2684	COG0501	Belongs to the peptidase M48B family
ALEK_2685	COG0588	phosphoglycerate mutase activity
ALEK_2688	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ALEK_2690	COG0706	membrane insertase activity
ALEK_2691	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ALEK_2692	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ALEK_2694	COG0542	response to heat
ALEK_2698	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ALEK_2701	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ALEK_2702	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ALEK_2703	COG3437	response regulator, receiver
ALEK_2704	COG3437	response regulator, receiver
ALEK_2706	COG0069	glutamate synthase activity
ALEK_2707	COG2259	Doxx family
ALEK_2708	COG0179	Fumarylacetoacetate (FAA) hydrolase
ALEK_2710	COG2259	Doxx family
ALEK_2719	COG0138	bifunctional purine biosynthesis protein purh
ALEK_2722	COG4263	nitrous-oxide reductase activity
ALEK_2725	COG0437	4 iron, 4 sulfur cluster binding
ALEK_2728	COG0348	domain, Protein
ALEK_2729	COG1131	(ABC) transporter
ALEK_2731	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ALEK_2732	COG0739	heme binding
ALEK_2733	COG2239	Acts as a magnesium transporter
ALEK_2737	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ALEK_2740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ALEK_2741	COG0606	chelatase, subunit chli
ALEK_2743	COG0840	transmembrane signaling receptor activity
ALEK_2745	COG0242	peptide deformylase activity
ALEK_2746	COG0740	serine-type endopeptidase activity
ALEK_2747	COG0544	peptidyl-prolyl cis-trans isomerase activity
ALEK_2748	COG2304	oxidoreductase activity
ALEK_2749	COG2326	polyphosphate kinase activity
ALEK_2752	COG1773	rubredoxin
ALEK_2767	COG0840	transmembrane signaling receptor activity
ALEK_2768	COG0745	RESPONSE REGULATOR receiver
ALEK_2775	COG0716	FMN binding
ALEK_2786	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ALEK_2793	COG0159	tryptophan synthase activity
ALEK_2795	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ALEK_2796	COG2255	four-way junction helicase activity
ALEK_2797	COG0628	permease
ALEK_2800	COG4628	conserved protein (DUF2132)
ALEK_2803	COG0745	RESPONSE REGULATOR receiver
ALEK_2804	COG0642	Histidine kinase
ALEK_2806	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ALEK_2809	COG0542	response to heat
ALEK_2810	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ALEK_2811	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ALEK_2813	COG0318	PFAM AMP-dependent synthetase and ligase
ALEK_2814	COG2030	dehydratase
ALEK_2823	COG0840	transmembrane signaling receptor activity
ALEK_2825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ALEK_2832	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ALEK_2833	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ALEK_2834	COG1157	protein secretion by the type III secretion system
ALEK_2836	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ALEK_2840	COG1677	Flagellar hook-basal body complex protein FliE
ALEK_2842	COG0455	bacterial-type flagellum organization
ALEK_2843	COG1419	protein localization to endoplasmic reticulum
ALEK_2846	COG3951	Flagellar rod assembly protein muramidase FlgJ
ALEK_2848	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ALEK_2849	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ALEK_2853	COG1749	Flagellar hook protein flgE
ALEK_2858	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ALEK_2859	COG1766	The M ring may be actively involved in energy transduction
ALEK_2860	COG1815	bacterial-type flagellum-dependent cell motility
ALEK_2861	COG4786	Flagellar basal body rod
ALEK_2863	COG0745	RESPONSE REGULATOR receiver
ALEK_2867	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ALEK_2869	COG0228	four-way junction DNA binding
ALEK_2870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ALEK_2872	COG1519	Transferase
ALEK_2872	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ALEK_2874	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ALEK_2875	COG0752	glycyl-tRNA synthetase alpha subunit
ALEK_2876	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ALEK_2892	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ALEK_2893	COG0497	DNA recombination
ALEK_2894	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ALEK_2895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ALEK_2896	COG0049	tRNA binding
ALEK_2897	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ALEK_2899	COG0583	DNA-binding transcription factor activity
ALEK_2900	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ALEK_2901	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ALEK_2904	COG2267	carboxylic ester hydrolase activity
ALEK_2905	COG0251	oxidation-reduction process
ALEK_2906	COG2855	membrane
ALEK_2907	COG1671	Belongs to the UPF0178 family
ALEK_2909	COG4895	conserved protein (DUF2196)
ALEK_2911	COG0038	chloride channel
ALEK_2913	COG0840	transmembrane signaling receptor activity
ALEK_2916	COG2202	Pas domain
ALEK_2916	COG2200	EAL domain
ALEK_2916	COG2199	diguanylate cyclase activity
ALEK_2918	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ALEK_2919	COG0085	RNA polymerase activity
ALEK_2920	COG0222	ribosome binding
ALEK_2921	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ALEK_2922	COG0081	regulation of translation
ALEK_2923	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ALEK_2924	COG0250	Participates in transcription elongation, termination and antitermination
ALEK_2927	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ALEK_2928	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ALEK_2934	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ALEK_2935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ALEK_2937	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ALEK_2938	COG0174	glutamine synthetase
ALEK_2940	COG0314	molybdopterin synthase activity
ALEK_2942	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ALEK_2943	COG1968	undecaprenyl-diphosphatase activity
ALEK_2945	COG0772	Belongs to the SEDS family
ALEK_2947	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ALEK_2957	COG0512	Glutamine amidotransferase of anthranilate synthase
ALEK_2959	COG1840	ABC-type Fe3 transport system, periplasmic component
ALEK_2961	COG3842	ATPase activity
ALEK_2962	COG3706	GGDEF domain
ALEK_2963	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ALEK_2964	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ALEK_2965	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_2966	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_2967	COG0649	NAD binding
ALEK_2967	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_2968	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ALEK_2970	COG0372	Belongs to the citrate synthase family
ALEK_2971	COG1034	ATP synthesis coupled electron transport
ALEK_2972	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ALEK_2973	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_2974	COG0839	Belongs to the complex I subunit 6 family
ALEK_2975	COG0713	ATP synthesis coupled electron transport
ALEK_2976	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ALEK_2978	COG1007	ATP synthesis coupled electron transport
ALEK_2980	COG1053	succinate dehydrogenase
ALEK_2981	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ALEK_2984	COG0519	Catalyzes the synthesis of GMP from XMP
ALEK_2985	COG1451	nucleotide metabolic process
ALEK_2990	COG2183	response to ionizing radiation
ALEK_2994	COG0251	oxidation-reduction process
ALEK_2997	COG2095	MarC family integral membrane protein
ALEK_2998	COG0765	amino acid transport
ALEK_3004	COG0500	methyltransferase
ALEK_3005	COG0640	Transcriptional regulator
ALEK_3007	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ALEK_3008	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ALEK_3014	COG0514	ATP-dependent DNA helicase (RecQ)
ALEK_3016	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ALEK_3021	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ALEK_3022	COG0372	Belongs to the citrate synthase family
ALEK_3023	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ALEK_3024	COG2828	Protein conserved in bacteria
ALEK_3025	COG2203	Gaf domain
ALEK_3025	COG2199	diguanylate cyclase activity
ALEK_3027	COG1879	ABC-type sugar transport system periplasmic component
ALEK_3029	COG0181	hydroxymethylbilane synthase activity
ALEK_3032	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ALEK_3033	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ALEK_3037	COG2011	ABC-type metal ion transport system permease component
ALEK_3038	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ALEK_3039	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ALEK_3040	COG0450	alkyl hydroperoxide reductase
ALEK_3042	COG0105	UTP biosynthetic process
ALEK_3044	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ALEK_3045	COG0416	fatty acid biosynthetic process
ALEK_3046	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ALEK_3048	COG0745	RESPONSE REGULATOR receiver
ALEK_3049	COG2353	YceI-like domain
ALEK_3052	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ALEK_3058	COG2201	protein-glutamate methylesterase activity
ALEK_3060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ALEK_3061	COG0540	Belongs to the ATCase OTCase family
ALEK_3063	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ALEK_3065	COG3852	Histidine kinase
ALEK_3066	COG0469	pyruvate kinase activity
ALEK_3069	COG0642	Histidine kinase
ALEK_3072	COG0792	nuclease activity
ALEK_3073	COG0475	glutathione-regulated potassium exporter activity
ALEK_3073	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ALEK_3075	COG1917	Cupin 2, conserved barrel domain protein
ALEK_3075	COG2207	Transcriptional regulator
ALEK_3076	COG0156	8-amino-7-oxononanoate synthase activity
ALEK_3078	COG0288	reversible hydration of carbon dioxide
ALEK_3080	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ALEK_3082	COG2121	Domain of unknown function (DUF374)
ALEK_3083	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALEK_3085	COG0195	Participates in both transcription termination and antitermination
ALEK_3086	COG0215	cysteine-tRNA ligase activity
ALEK_3089	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ALEK_3090	COG0629	single-stranded DNA binding
ALEK_3091	COG0360	Binds together with S18 to 16S ribosomal RNA
ALEK_3093	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ALEK_3096	COG0557	exoribonuclease II activity
ALEK_3099	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ALEK_3103	COG1917	Cupin 2, conserved barrel domain protein
ALEK_3103	COG2207	Transcriptional regulator
ALEK_3104	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ALEK_3107	COG0436	Aminotransferase
ALEK_3111	COG3706	GGDEF domain
ALEK_3112	COG0343	queuine tRNA-ribosyltransferase activity
ALEK_3113	COG1450	Type ii and iii secretion system protein
ALEK_3118	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ALEK_3123	COG5001	Diguanylate cyclase
ALEK_3123	COG4251	negative regulation of phosphorylation
ALEK_3123	COG3706	GGDEF domain
ALEK_3123	COG2203	Gaf domain
ALEK_3125	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ALEK_3126	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ALEK_3128	COG0560	Phosphoserine phosphatase
ALEK_3129	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ALEK_3131	COG0784	Response regulator, receiver
ALEK_3131	COG3437	response regulator, receiver
ALEK_3132	COG0736	holo-[acyl-carrier-protein] synthase activity
ALEK_3133	COG0601	transmembrane transport
ALEK_3134	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ALEK_3136	COG2353	YceI-like domain
ALEK_3137	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALEK_3141	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ALEK_3150	COG1706	bacterial-type flagellum-dependent cell motility
ALEK_3151	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ALEK_3152	COG0418	dihydroorotase activity
ALEK_3154	COG0004	ammonium transporteR
ALEK_3156	COG0004	ammonium transporteR
ALEK_3157	COG0840	transmembrane signaling receptor activity
ALEK_3158	COG2200	EAL domain
ALEK_3159	COG1116	anion transmembrane transporter activity
ALEK_3161	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ALEK_3161	COG1116	anion transmembrane transporter activity
ALEK_3162	COG2223	nitrite transmembrane transporter activity
ALEK_3163	COG2815	serine threonine protein kinase
ALEK_3163	COG0515	serine threonine protein kinase
ALEK_3164	COG0243	molybdopterin cofactor binding
ALEK_3166	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ALEK_3167	COG0243	molybdopterin cofactor binding
ALEK_3172	COG1346	cytolysis
ALEK_3174	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ALEK_3180	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ALEK_3181	COG0204	Acyl-transferase
ALEK_3181	COG0318	PFAM AMP-dependent synthetase and ligase
ALEK_3183	COG2962	Rard protein
ALEK_3184	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_3184	COG4191	Histidine kinase
ALEK_3187	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ALEK_3190	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ALEK_3192	COG0640	Transcriptional regulator
ALEK_3193	COG2258	MOSC domain
ALEK_3194	COG1346	cytolysis
ALEK_3198	COG2084	Dehydrogenase
ALEK_3201	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ALEK_3202	COG4191	Histidine kinase
ALEK_3208	COG0745	RESPONSE REGULATOR receiver
ALEK_3215	COG0129	dihydroxy-acid dehydratase activity
ALEK_3216	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ALEK_3217	COG0745	RESPONSE REGULATOR receiver
ALEK_3218	COG0642	Histidine kinase
ALEK_3220	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ALEK_3221	COG1492	cobalamin metabolic process
ALEK_3222	COG3437	response regulator, receiver
ALEK_3222	COG0784	Response regulator, receiver
ALEK_3227	COG2199	diguanylate cyclase activity
ALEK_3227	COG2203	Gaf domain
ALEK_3232	COG2095	MarC family integral membrane protein
ALEK_3233	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ALEK_3236	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ALEK_3238	COG2200	EAL domain
ALEK_3238	COG3287	FIST C domain
ALEK_3238	COG2199	diguanylate cyclase activity
ALEK_3239	COG0688	phosphatidylethanolamine metabolic process
ALEK_3241	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ALEK_3243	COG0443	Heat shock 70 kDa protein
ALEK_3244	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ALEK_3246	COG2358	TRAP transporter, solute receptor (TAXI family
ALEK_3248	COG0745	RESPONSE REGULATOR receiver
ALEK_3250	COG0101	tRNA pseudouridine synthase activity
ALEK_3252	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ALEK_3253	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ALEK_3255	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ALEK_3257	COG0513	Belongs to the DEAD box helicase family
ALEK_3258	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ALEK_3276	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ALEK_3282	COG2089	acid synthase
ALEK_3284	COG1086	Polysaccharide biosynthesis protein
ALEK_3286	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ALEK_3287	COG0148	phosphopyruvate hydratase activity
ALEK_3290	COG0475	glutathione-regulated potassium exporter activity
ALEK_3290	COG0569	domain protein
ALEK_3291	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ALEK_3294	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ALEK_3295	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ALEK_3297	COG1007	ATP synthesis coupled electron transport
ALEK_3299	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ALEK_3300	COG0713	ATP synthesis coupled electron transport
ALEK_3302	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_3303	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ALEK_3304	COG1034	ATP synthesis coupled electron transport
ALEK_3307	COG0649	NAD binding
ALEK_3308	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_3309	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_3310	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_3311	COG0840	transmembrane signaling receptor activity
ALEK_3320	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ALEK_3329	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ALEK_3331	COG3287	FIST C domain
ALEK_3331	COG2200	EAL domain
ALEK_3331	COG2199	diguanylate cyclase activity
ALEK_3332	COG0745	RESPONSE REGULATOR receiver
ALEK_3335	COG3706	GGDEF domain
ALEK_3338	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ALEK_3339	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALEK_3340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ALEK_3341	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALEK_3342	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ALEK_3343	COG1077	Cell shape determining protein MreB Mrl
ALEK_3346	COG0840	transmembrane signaling receptor activity
ALEK_3347	COG0445	tRNA wobble uridine modification
ALEK_3349	COG0348	domain, Protein
ALEK_3350	COG0504	CTP synthase activity
ALEK_3351	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ALEK_3359	COG0587	DNA-directed DNA polymerase activity
ALEK_3360	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ALEK_3365	COG0315	cyclic pyranopterin monophosphate synthase activity
ALEK_3366	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ALEK_3376	COG0670	Belongs to the BI1 family
ALEK_3377	COG0352	thiamine-phosphate diphosphorylase activity
ALEK_3379	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ALEK_3381	COG0233	cytoplasmic translational termination
ALEK_3382	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ALEK_3383	COG1714	RDD family
ALEK_3384	COG2814	Major facilitator Superfamily
ALEK_3385	COG0840	transmembrane signaling receptor activity
ALEK_3386	COG3706	GGDEF domain
ALEK_3387	COG0745	RESPONSE REGULATOR receiver
ALEK_3388	COG3022	response to hydroperoxide
ALEK_3395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ALEK_3396	COG1012	belongs to the aldehyde dehydrogenase family
ALEK_3409	COG2081	HI0933 family
ALEK_3410	COG2258	MOSC domain
ALEK_3415	COG1959	2 iron, 2 sulfur cluster binding
ALEK_3416	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ALEK_3419	COG0175	sulfate reduction
ALEK_3420	COG2895	sulfate adenylyltransferase (ATP) activity
ALEK_3421	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ALEK_3423	COG1408	metallophosphoesterase
ALEK_3427	COG2066	Belongs to the glutaminase family
ALEK_3429	COG4772	TonB-dependent receptor
ALEK_3431	COG1595	DNA-templated transcription, initiation
ALEK_3432	COG0697	spore germination
ALEK_3433	COG2860	membrane
ALEK_3434	COG2203	Gaf domain
ALEK_3434	COG3706	GGDEF domain
ALEK_3434	COG4251	negative regulation of phosphorylation
ALEK_3434	COG5001	Diguanylate cyclase
ALEK_3436	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ALEK_3437	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group