locus-tag class description Arnit_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Arnit_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Arnit_0003 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Arnit_0004 ENOG4105MRD Phage derived protein Gp49-like (DUF891) Arnit_0006 ENOG4108VKG metal-dependent hydrolase Arnit_0008 ENOG4105CH5 extracellular solute-binding protein, family 7 Arnit_0010 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Arnit_0011 ENOG4105C26 Dehydrogenase Arnit_0013 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Arnit_0019 ENOG4105CAY ferredoxin--nadp reductase Arnit_0020 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) Arnit_0023 ENOG4105W39 Membrane Arnit_0024 ENOG4105F4R Transcriptional regulator mode Arnit_0025 ENOG4105BZU Histidine kinase Arnit_0026 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding Arnit_0028 ENOG4108M5V ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Arnit_0031 ENOG4108JUA Transcriptional regulator Arnit_0034 ENOG4105CPC Aldo Keto reductase Arnit_0035 ENOG4105E3S small subunit Arnit_0036 ENOG4105DPX Hydrogenase, large subunit Arnit_0037 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Arnit_0039 ENOG4105ECW sulfate abc transporter Arnit_0042 ENOG4105E0C molybdate abc transporter Arnit_0044 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Arnit_0045 ENOG4105F4R Transcriptional regulator mode Arnit_0046 ENOG4105CY9 nitrogenase molybdenum-iron protein beta chain Arnit_0047 ENOG4105D0B Nitrogenase protein alpha chain Arnit_0049 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) Arnit_0050 ENOG4107ZYR domain protein Arnit_0051 ENOG4105CZN Potassium uptake protein Arnit_0052 ENOG4105EEX Two component transcriptional regulator (Winged helix family Arnit_0053 ENOG4105C08 Histidine kinase Arnit_0054 ENOG4107SDU Methyl-accepting chemotaxis Arnit_0055 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Arnit_0056 ENOG4105KXW Ferredoxin Arnit_0059 ENOG4105R88 May protect the nitrogenase Fe-Mo protein from oxidative damage (By similarity) Arnit_0060 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) Arnit_0061 ENOG4108VQE nitrogen fixation protein Arnit_0062 ENOG4108UR2 Nitrogen fixation protein NifX Arnit_0066 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) Arnit_0068 ENOG4105DK8 Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN Arnit_0071 ENOG4105DSF transport protein Arnit_0073 ENOG4105D0B Nitrogenase protein alpha chain Arnit_0077 ENOG4105CNW domain protein Arnit_0079 ENOG4105ND9 Nitrogenase-associated protein Arnit_0082 ENOG4107SDT Homocitrate synthase Arnit_0088 ENOG4105EI2 Pseudouridine synthase Arnit_0089 ENOG4107QTF adenylosuccinate lyase Arnit_0090 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Arnit_0091 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Arnit_0093 ENOG4105BZU Histidine kinase Arnit_0096 ENOG4108594 Permease of the drug metabolite transporter Arnit_0098 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase Arnit_0102 ENOG4105KJF protein tyrosine phosphatase Arnit_0103 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase Arnit_0110 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Arnit_0111 ENOG4105F8J Adenylate Guanylate cyclase Arnit_0114 ENOG4105KVH Transcriptional regulator Arnit_0116 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Arnit_0118 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Arnit_0119 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) Arnit_0122 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Arnit_0124 ENOG4105CH5 extracellular solute-binding protein, family 7 Arnit_0126 ENOG4105BZU Histidine kinase Arnit_0127 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) Arnit_0128 ENOG4107QR9 Iron-sulfur cluster binding protein Arnit_0129 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Arnit_0131 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Arnit_0132 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein Arnit_0133 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Arnit_0134 ENOG4105C1J atp-dependent rna helicase Arnit_0136 ENOG4105CJ3 phosphate transporter Arnit_0138 ENOG4105CAQ asparagine synthetase Arnit_0141 ENOG4105E33 succinate dehydrogenase Arnit_0144 ENOG4105C5I Dehydrogenase Arnit_0145 ENOG4108IAB Phoh family Arnit_0146 ENOG4108YXA Membrane Arnit_0147 ENOG4105D1H recombination factor protein RarA Arnit_0148 ENOG4105FE9 pseudouridine synthase Arnit_0149 ENOG4105C2X Arabinose 5-phosphate isomerase Arnit_0150 ENOG4105CN5 Metallo-Beta-Lactamase Arnit_0151 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Arnit_0152 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Arnit_0155 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Arnit_0156 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Arnit_0158 ENOG4105C59 p-type ATPase Arnit_0164 ENOG4108IJF Heavy metal efflux pump, CzcA Arnit_0167 ENOG4105D6E homoserine dehydrogenase Arnit_0168 ENOG4105CHM Aminotransferase Arnit_0170 ENOG4105C2N RNA methyltransferase TrmH family group 3 Arnit_0172 ENOG41082DI 50s ribosomal protein l31 Arnit_0173 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Arnit_0174 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase Arnit_0175 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Arnit_0190 ENOG41068WC Domain of unknown function (DUF955) Arnit_0196 ENOG4105D9P serine threonine protein kinase Arnit_0198 ENOG4108ZF3 Phosphatase Arnit_0200 ENOG4105CH5 extracellular solute-binding protein, family 7 Arnit_0202 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Arnit_0203 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Arnit_0208 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Arnit_0209 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase Arnit_0210 ENOG4105D1Z hydroxypyruvate reductase Arnit_0211 ENOG4105C3Q Glycosyl transferase, family 2 Arnit_0213 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Arnit_0214 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Arnit_0215 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) Arnit_0216 ENOG4105C01 Dihydroxy-acid dehydratase Arnit_0217 ENOG4108UHU Aldolase Arnit_0219 ENOG4107QP8 phosphohexose isomerase Arnit_0222 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA Arnit_0223 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR Arnit_0224 ENOG4108UR8 BAX protein Arnit_0225 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Arnit_0226 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Arnit_0227 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Arnit_0228 ENOG4105CXB phosphoribosylaminoimidazole synthetase Arnit_0231 ENOG4105FS7 Transcriptional regulator Arnit_0232 ENOG4105C2I pirin domain protein Arnit_0233 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) Arnit_0234 ENOG4108YYC ycei family Arnit_0236 ENOG4107UUH Aminotransferase Arnit_0237 ENOG4105CYE ATP phosphoribosyltransferase regulatory subunit Arnit_0238 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Arnit_0240 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Arnit_0243 ENOG4108MRH transcriptional regulatory protein Arnit_0244 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Arnit_0247 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) Arnit_0249 ENOG4105D1F ATP-binding protein Arnit_0250 ENOG4105C28 cystathionine Arnit_0254 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Arnit_0257 ENOG4105CM2 brancheD-chain amino acid aminotransferase Arnit_0258 ENOG41088CC tellurite resistance protein tehB Arnit_0261 ENOG4108R5S membrane Arnit_0262 ENOG4107R5B glutamine synthetase Arnit_0263 ENOG4105W4W Transcriptional regulator Arnit_0267 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) Arnit_0275 ENOG4105PW4 Sugar fermentation stimulation protein homolog Arnit_0276 ENOG4108KK1 membrane protein AbrB duplication Arnit_0277 ENOG4107B2H carbonic anhydrase Arnit_0284 ENOG4105DDK oxidoreductase, beta subunit Arnit_0285 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) Arnit_0286 ENOG4105WGB oxidoreductase, delta subunit Arnit_0287 ENOG4105EJ5 oxidoreductase gamma subunit Arnit_0288 ENOG4107XGZ Hydrolase Arnit_0290 ENOG4108UJD 30S ribosomal protein S9 Arnit_0291 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Arnit_0293 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Arnit_0295 ENOG4108UTW Plays a role in the regulation of phosphate uptake Arnit_0296 ENOG4108M8H domain protein Arnit_0297 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Arnit_0298 ENOG4108317 Binds directly to 16S ribosomal RNA (By similarity) Arnit_0299 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Arnit_0300 ENOG410813J This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Arnit_0301 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Arnit_0302 ENOG41080AZ Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) Arnit_0303 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Arnit_0304 ENOG41084M8 50s ribosomal protein L35 Arnit_0305 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Arnit_0308 ENOG4105CUT histidyl-tRNA synthetase Arnit_0309 ENOG4105KNE Phosphatidate cytidylyltransferase Arnit_0310 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Arnit_0314 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Arnit_0315 ENOG4108ZJT translation initiation factor, Sui1 Arnit_0316 ENOG4108ENG carbohydrate kinase, YjeF related protein Arnit_0317 ENOG4105VF7 tolerance protein Arnit_0318 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Arnit_0325 ENOG4105CYW agmatinase Arnit_0326 ENOG4105E5Q amino acid AbC transporter Arnit_0327 ENOG4105E5Q amino acid AbC transporter Arnit_0328 ENOG4108JEH abc transporter atp-binding protein Arnit_0329 ENOG4105DUM transcriptional regulator, lysR family Arnit_0334 ENOG4108IJ7 Glycine betaine Arnit_0335 ENOG4108HQS Glycine betaine Arnit_0336 ENOG4105GIJ Glycine betaine Arnit_0337 ENOG4107HP6 Transcriptional regulator Arnit_0338 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Arnit_0341 ENOG4105JSC dimethylmenaquinone methyltransferase Arnit_0342 ENOG4105C9B Cysteine desulfurase Arnit_0343 ENOG41084AG Acylphosphatase Arnit_0344 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Arnit_0346 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) Arnit_0348 ENOG4105FD8 phosphonate metabolism protein PhnM Arnit_0349 ENOG4105HRV phosphonate c-p lyase system protein phnl Arnit_0350 ENOG4105ENV phosphonate C-P lyase system protein PhnK Arnit_0357 ENOG4105D5T phosphonate abc transporter Arnit_0358 ENOG4105FDP GntR family transcriptional regulator Arnit_0359 ENOG4105BZU Histidine kinase Arnit_0362 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_0363 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Arnit_0364 ENOG4107QP8 phosphohexose isomerase Arnit_0373 ENOG4105DJY efflux transporter, rnd family, mfp subunit Arnit_0374 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Arnit_0375 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Arnit_0378 ENOG4105CVP deoxyribo-dipyrimidine photolyase Arnit_0381 ENOG4105DY9 regulatoR Arnit_0382 ENOG4108V06 Glutathione peroxidase Arnit_0384 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Arnit_0387 ENOG4105DWF phosphomethylpyrimidine kinase Arnit_0388 ENOG41080BE Methyl-accepting chemotaxis sensory transducer Arnit_0388 ENOG41080BE Methyl-accepting chemotaxis sensory transducer Arnit_0390 ENOG4107VQW regulatoR Arnit_0392 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) Arnit_0393 ENOG4105I03 Flagellin Arnit_0394 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) Arnit_0395 ENOG4108HGU Histidine kinase Arnit_0397 ENOG4108IFG nitrite reductase, (NAD(P)H) Arnit_0398 ENOG4105D9P serine threonine protein kinase Arnit_0399 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) Arnit_0402 ENOG4105EFQ Two component transcriptional regulator (Winged helix family Arnit_0407 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_0408 ENOG4108TX7 Arnit_0410 ENOG4105CN1 protease Arnit_0411 ENOG4105C8V SAICAR synthetase Arnit_0412 ENOG4105VR9 phosphoribosylformylglycinamidine synthase Arnit_0413 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Arnit_0415 ENOG4105E9Q Acyl-transferase Arnit_0416 ENOG4105WMR Protein CrcB homolog Arnit_0417 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Arnit_0418 ENOG4105C75 arginyL-tRNA synthetase Arnit_0421 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Arnit_0423 ENOG4105BZA Phosphoglycerate kinase Arnit_0424 ENOG4105CP7 Triose-phosphate isomerase Arnit_0425 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH Arnit_0426 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Arnit_0427 ENOG4105D4U had-superfamily hydrolase, subfamily iia Arnit_0428 ENOG4105CQC Prephenate dehydratase Arnit_0429 ENOG4105CIH Imidazole acetol-phosphate transaminase Arnit_0430 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Arnit_0432 ENOG4107YJQ MAF-like protein Arnit_0433 ENOG4105C2C drug resistance transporter, Bcr CflA Arnit_0437 ENOG4107TT5 NLP P60 protein Arnit_0439 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Arnit_0441 ENOG4105C3M thioredoxin reductase Arnit_0442 ENOG4107QPK )-transporter Arnit_0444 ENOG4105XJC Two component transcriptional regulator (Winged helix family Arnit_0446 ENOG4105E33 succinate dehydrogenase Arnit_0447 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) Arnit_0448 ENOG4108S24 Fumarate reduCtase Arnit_0449 ENOG4105C3M thioredoxin reductase Arnit_0450 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Arnit_0452 ENOG4105N5T Radical SAM Protein Arnit_0454 ENOG4105C4R Atp-dependent dna helicase Arnit_0455 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Arnit_0456 ENOG4107Z7S Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Arnit_0457 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Arnit_0458 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i Arnit_0467 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) Arnit_0469 ENOG4105YIC Major outer membrane protein Arnit_0471 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Arnit_0473 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Arnit_0474 ENOG4105BZR domain protein Arnit_0476 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Arnit_0478 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) Arnit_0480 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Arnit_0481 ENOG4105MGB Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Arnit_0482 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) Arnit_0486 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Arnit_0487 ENOG4108JQ1 Dehydrogenase Arnit_0488 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Arnit_0489 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Arnit_0490 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Arnit_0491 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Arnit_0492 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Arnit_0493 ENOG4107YU2 histidine triad (hIT) protein Arnit_0494 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) Arnit_0495 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Arnit_0496 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Arnit_0497 ENOG4105CHR reductase Arnit_0498 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) Arnit_0500 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) Arnit_0501 ENOG4105CVM Molybdenum cofactor synthesis domain protein Arnit_0503 ENOG4107YV6 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Arnit_0504 ENOG4105EFQ Two component transcriptional regulator (Winged helix family Arnit_0508 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Arnit_0509 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Arnit_0510 ENOG4107QID Threonine synthase Arnit_0511 ENOG4105CAS nag kinase Arnit_0514 ENOG4107WJT it plays a direct role in the translocation of protons across the membrane (By similarity) Arnit_0515 ENOG4105C7B Threonine dehydratase Arnit_0516 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) Arnit_0518 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Arnit_0519 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Arnit_0521 ENOG4105F6S Spore photoproduct lyase Arnit_0523 ENOG4105DIK (ABC) transporter Arnit_0525 ENOG4107T5V SNARE associated Golgi Arnit_0526 ENOG410904N short-chain dehydrogenase reductase Arnit_0527 ENOG4105CJW magnesium transporter Arnit_0528 ENOG4107XM3 UPF0442 protein Arnit_0529 ENOG4105DWK Membrane Arnit_0530 ENOG4105T16 Transcriptional regulator (AraC family) Arnit_0532 ENOG4105PGM cation diffusion facilitator family transporter Arnit_0535 ENOG4107ZSV Receptor Arnit_0537 ENOG4105BZ1 (ABC) transporter Arnit_0540 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) Arnit_0541 ENOG4105EAB amino acid AbC transporter Arnit_0542 ENOG4105E5Q amino acid AbC transporter Arnit_0544 ENOG4108VHG Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) Arnit_0545 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Arnit_0548 ENOG4105C31 Tryptophanyl-tRNA synthetase Arnit_0553 ENOG4105E0K tonB-dependent siderophore receptor Arnit_0555 ENOG4107VQW regulatoR Arnit_0556 ENOG4105BZU Histidine kinase Arnit_0560 ENOG4105CE1 Ferrous iron transport protein b Arnit_0564 ENOG4109015 Biopolymer transport protein exbD tolR Arnit_0570 ENOG4105E0K tonB-dependent siderophore receptor Arnit_0571 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Arnit_0574 ENOG4105DCF alanine dehydrogenase Arnit_0576 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_0578 ENOG4105CDA abc transporter atp-binding protein Arnit_0579 ENOG4105DRP amino acid AbC transporter Arnit_0580 ENOG4105EZ7 amino acid ABC transporter Arnit_0585 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) Arnit_0586 ENOG4105GXZ Ferredoxin-type protein NapH Arnit_0587 ENOG4108BGM Quinol dehydrogenase periplasmic component Arnit_0588 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Arnit_0589 ENOG4108MTB glycosyl transferase family Arnit_0590 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Arnit_0591 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Arnit_0594 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Arnit_0596 ENOG4105DKW ABC transporter Arnit_0597 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Arnit_0599 ENOG4108KA0 Inherit from COG: Phosphoesterase, DHHA1 Arnit_0600 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Arnit_0601 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division Arnit_0602 ENOG41080BE Methyl-accepting chemotaxis sensory transducer Arnit_0603 ENOG41085FC arsR family transcriptional regulator Arnit_0604 ENOG4107R5R arsenical pump membrane protein Arnit_0605 ENOG4108UXE Protein tyrosine phosphatase Arnit_0607 ENOG4105K4P CoA-binding domain protein Arnit_0608 ENOG4105DHQ Histidine kinase Arnit_0609 ENOG4105ETX regulatoR Arnit_0610 ENOG4105EIN peptidylprolyl cis-trans isomerase Arnit_0611 ENOG4105D2N Aldolase Arnit_0612 ENOG4105DFP Integrase Arnit_0632 ENOG4105KVH Transcriptional regulator Arnit_0635 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Arnit_0637 ENOG4105BZU Histidine kinase Arnit_0638 ENOG4106GFD transport protein Arnit_0642 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Arnit_0643 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Arnit_0646 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Arnit_0647 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Arnit_0649 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Arnit_0650 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) Arnit_0651 ENOG4105VIE preprotein translocase, subunit YajC Arnit_0652 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Arnit_0653 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Arnit_0657 ENOG4105C8T Leucyl-tRNA synthetase Arnit_0659 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Arnit_0660 ENOG4105DR5 peptidase Arnit_0663 ENOG4105CKD glutathione-regulated potassium-efflux system protein Arnit_0666 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_0668 ENOG4108JA2 transcriptioN-repair coupling factor Arnit_0669 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor Arnit_0671 ENOG4105C4M (Ubiquinol oxidase) subunit I Arnit_0677 ENOG4105DHQ Histidine kinase Arnit_0678 ENOG4105CBX hi0933 family Arnit_0680 ENOG4105FDK ABC transporter Arnit_0683 ENOG4105D48 metallophosphoesterase Arnit_0687 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Arnit_0688 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Arnit_0689 ENOG4108V3W Chemotaxis protein, CheW Arnit_0690 ENOG4105EQD regulatoR Arnit_0692 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Arnit_0694 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Arnit_0695 ENOG41084FT Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Arnit_0697 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Arnit_0698 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Arnit_0700 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Arnit_0701 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Arnit_0702 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) Arnit_0703 ENOG4107U6I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Arnit_0704 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) Arnit_0705 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters Arnit_0707 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Arnit_0708 ENOG4107RQ5 Methylates ribosomal protein L11 (By similarity) Arnit_0709 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Arnit_0711 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Arnit_0715 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Arnit_0717 ENOG4105CUB amino acid Arnit_0718 ENOG4107FQ9 ethanolamine ammonia-lyase Arnit_0719 ENOG4105CPD ethanolamine ammonia-lyase Arnit_0720 ENOG4105BZU Histidine kinase Arnit_0723 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Arnit_0724 ENOG4105ECP epimerase Arnit_0725 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Arnit_0727 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_0730 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) Arnit_0731 ENOG4108JPZ Monovalent cation H antiporter subunit D Arnit_0732 ENOG4107TDF Formate hydrogenlyase subunit 4 Arnit_0733 ENOG4107WQX hydrogenase 4 membrane subunit Arnit_0734 ENOG4108JPZ Monovalent cation H antiporter subunit D Arnit_0735 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Arnit_0737 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit Arnit_0740 ENOG4105TMB Formate nitrite transporter Arnit_0741 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Arnit_0744 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Arnit_0746 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Arnit_0747 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Arnit_0748 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Arnit_0749 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Arnit_0750 ENOG4105DC7 peptidase M24 Arnit_0751 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Arnit_0752 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Arnit_0754 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Arnit_0755 ENOG4108IJ2 phosphate acetyltransferase Arnit_0756 ENOG4106492 Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO). Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO (By similarity) Arnit_0758 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Arnit_0761 ENOG4107QN1 sodium solute Arnit_0765 ENOG4105CEV competence damage-inducible protein Arnit_0766 ENOG4107RSR Malate quinone oxidoreductase Arnit_0767 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Arnit_0771 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Arnit_0776 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Arnit_0778 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_0779 ENOG4105CE9 30S ribosomal protein S2 Arnit_0780 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Arnit_0783 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Arnit_0784 ENOG4105BZU Histidine kinase Arnit_0785 ENOG4105C59 p-type ATPase Arnit_0788 ENOG4105BZ1 (ABC) transporter Arnit_0789 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Arnit_0791 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein Arnit_0792 ENOG4107S90 membrAne Arnit_0793 ENOG4105QNR S1 RNA binding domain protein Arnit_0794 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) Arnit_0796 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) Arnit_0797 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) Arnit_0800 ENOG4105ENA helicase Arnit_0801 ENOG4105BZU Histidine kinase Arnit_0803 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Arnit_0805 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase Arnit_0812 ENOG4105C1P efflux transporter, rnd family, mfp subunit Arnit_0813 ENOG4105BZS acriflavin resistance protein Arnit_0814 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Arnit_0815 ENOG4105CVG Homoserine O-transsuccinylase Arnit_0820 ENOG4107RDB Major Facilitator Arnit_0821 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Arnit_0827 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Arnit_0830 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Arnit_0839 ENOG4108V0P LemA family Arnit_0840 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_0842 ENOG4105CHR reductase Arnit_0843 ENOG41084IH F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Arnit_0844 ENOG4105BZU Histidine kinase Arnit_0846 ENOG4105CJZ response regulator Arnit_0847 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_0848 ENOG4105BZU Histidine kinase Arnit_0850 ENOG4105CHR reductase Arnit_0852 ENOG4106AXJ AraC family transcriptional regulator Arnit_0856 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Arnit_0859 ENOG4105D7X high-affinity nickel-transporter Arnit_0860 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_0861 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_0862 ENOG4105CNG UPF0061 protein Arnit_0865 ENOG4105BZU Histidine kinase Arnit_0869 ENOG4105VG1 fes assembly suf system protein Arnit_0870 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) Arnit_0871 ENOG4105C9B Cysteine desulfurase Arnit_0873 ENOG4105C3K feS assembly ATPase SufC Arnit_0877 ENOG4105C26 Dehydrogenase Arnit_0878 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Arnit_0881 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component Arnit_0884 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Arnit_0885 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Arnit_0886 ENOG4105FDP GntR family transcriptional regulator Arnit_0887 ENOG4105FDP GntR family transcriptional regulator Arnit_0888 ENOG4105CH7 arginosuccinase Arnit_0890 ENOG4105CUZ uba thif-type nad fad binding protein Arnit_0891 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Arnit_0892 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) Arnit_0894 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Arnit_0895 ENOG4105C3F Signal peptidase i Arnit_0898 ENOG4105CSM endonuclease III Arnit_0907 ENOG4108YZG isomerase Arnit_0908 ENOG4105C3F Signal peptidase i Arnit_0909 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Arnit_0911 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Arnit_0912 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Arnit_0915 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Arnit_0917 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Arnit_0919 ENOG410692R Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) Arnit_0920 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Arnit_0922 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) Arnit_0923 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) Arnit_0924 ENOG4105CRQ synthase (Component I) Arnit_0926 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Arnit_0927 ENOG4105CRK lysyL-tRNA synthetase Arnit_0929 ENOG4105BZU Histidine kinase Arnit_0930 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Arnit_0932 ENOG4105CDU Replicative dna helicase Arnit_0933 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase Arnit_0938 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) Arnit_0939 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) Arnit_0940 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) Arnit_0941 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Arnit_0942 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Arnit_0944 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Arnit_0945 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) Arnit_0947 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Arnit_0948 ENOG4107QMZ Dehydrogenase Arnit_0949 ENOG4105KME endoribonuclease L-psp Arnit_0951 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Arnit_0953 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Arnit_0960 ENOG4105C3J Cysteine desulfurase Arnit_0962 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Arnit_0964 ENOG4105QAX Iron-sulfur Arnit_0966 ENOG4108J2R molybdopterin oxidoreductase Arnit_0971 ENOG4105QAX Iron-sulfur Arnit_0982 ENOG4108KS2 transglutaminase domain protein Arnit_0985 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase Arnit_0986 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) Arnit_0987 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) Arnit_0988 ENOG4105EM7 Selenocysteine-specific translation elongation factor Arnit_0993 ENOG4105VTR Integrase Arnit_1001 ENOG4105F8V Hydrolase, tatD family Arnit_1007 ENOG4105VXP Protein of unknown function DUF86 Arnit_1014 ENOG4105CKU formyltetrahydrofolate synthetase Arnit_1015 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) Arnit_1016 ENOG4105C8U phosphate abc transporter Arnit_1017 ENOG4105E2Z phosphate ABC transporter (Permease Arnit_1018 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Arnit_1023 ENOG41080BE Methyl-accepting chemotaxis sensory transducer Arnit_1024 ENOG4105EQX glucarate dehydratase Arnit_1025 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Arnit_1026 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Arnit_1027 ENOG4105C5I Dehydrogenase Arnit_1028 ENOG4105BZW Glycerate kinase Arnit_1032 ENOG4105CTX dehydratase Arnit_1034 ENOG4105DRR Transcriptional regulator, GntR family Arnit_1035 ENOG4105CA9 Pyruvate kinase Arnit_1041 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) Arnit_1046 ENOG4105C3G gtp-binding protein Arnit_1047 ENOG4108HGU Histidine kinase Arnit_1051 ENOG4105NBK UPF0345 protein Arnit_1052 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Arnit_1053 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Arnit_1054 ENOG4105BZU Histidine kinase Arnit_1056 ENOG4105C32 Amino acid ABC transporter (Permease) Arnit_1058 ENOG4105C0Z ABC transporter Arnit_1059 ENOG4108IV0 ABC, transporter Arnit_1062 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Arnit_1064 ENOG4105E5Q amino acid AbC transporter Arnit_1065 ENOG4105E5Q amino acid AbC transporter Arnit_1066 ENOG4108HW3 (ABC) transporter Arnit_1068 ENOG4105DHG Allantoate amidinohydrolase Arnit_1070 ENOG4108YZ9 Urea amidohydrolase subunit gamma Arnit_1071 ENOG4105CQM Urea amidohydrolase subunit alpha Arnit_1074 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) Arnit_1075 ENOG4106GFD transport protein Arnit_1076 ENOG4108PAU MotA TolQ exbB proton channel Arnit_1078 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Arnit_1079 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) Arnit_1081 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_1082 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Arnit_1083 ENOG4105CPF Cell wall formation (By similarity) Arnit_1085 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) Arnit_1090 ENOG4107QMZ Dehydrogenase Arnit_1094 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_1100 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Arnit_1102 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Arnit_1103 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Arnit_1104 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Arnit_1105 ENOG4105KZZ One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Arnit_1106 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Arnit_1107 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Arnit_1108 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Arnit_1109 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Arnit_1110 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Arnit_1111 ENOG41084HJ 50s ribosomal protein l29 Arnit_1112 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Arnit_1113 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Arnit_1114 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Arnit_1116 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Arnit_1117 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Arnit_1118 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Arnit_1119 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Arnit_1120 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Arnit_1121 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Arnit_1122 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Arnit_1123 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Arnit_1124 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Arnit_1125 ENOG4105BZU Histidine kinase Arnit_1129 ENOG4105C9M aspartyl-trna synthetase Arnit_1131 ENOG4105CCT upf0313 protein Arnit_1132 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Arnit_1133 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Arnit_1136 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Arnit_1137 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Arnit_1141 ENOG4105BZU Histidine kinase Arnit_1142 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Arnit_1152 ENOG4105CGK Exodeoxyribonuclease III Arnit_1153 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Arnit_1158 ENOG4105CQZ Histidine kinase Arnit_1159 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Arnit_1160 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Arnit_1161 ENOG4105BZU Histidine kinase Arnit_1162 ENOG4107SJ9 decarboxylase Arnit_1164 ENOG4105NF4 modulator of drug activity Arnit_1165 ENOG4105CF7 AraC family transcriptional regulator Arnit_1167 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) Arnit_1170 ENOG4105EQ0 Major Facilitator superfamily Arnit_1173 ENOG4108IG5 Transcriptional regulator Arnit_1180 ENOG4108V1U phospholipid-binding protein Arnit_1181 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Arnit_1186 ENOG4106TD9 Diguanylate cyclase Arnit_1190 ENOG4105C26 Dehydrogenase Arnit_1191 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Arnit_1195 ENOG4108U5N UPF0316 protein Arnit_1196 ENOG4108M3J Dehydrogenase Arnit_1197 ENOG410631K Membrane Arnit_1198 ENOG4105DUM transcriptional regulator, lysR family Arnit_1199 ENOG4105HMI Membrane Arnit_1200 ENOG4108IJ0 Aspartate ammonia-lyase Arnit_1203 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Arnit_1210 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_1212 ENOG4105D5U fad dependent oxidoreductase Arnit_1214 ENOG4105CH2 amidohydrolase Arnit_1215 ENOG4105CTU Proline racemase Arnit_1217 ENOG41080TK Universal stress protein Arnit_1218 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Arnit_1219 ENOG4108K1J Transporter DctQ Arnit_1220 ENOG4108KJ1 Trap dicarboxylate transporter, dctp subunit Arnit_1221 ENOG4105ENR peptidase, M24 Arnit_1223 ENOG4108JPW Aminotransferase Arnit_1226 ENOG4107QWP ABC-2 type transporter Arnit_1227 ENOG4107QWP ABC-2 type transporter Arnit_1228 ENOG4105CJ1 ABC, transporter Arnit_1229 ENOG4105D0S secretion protein (HlyD Arnit_1230 ENOG41090A1 ferritin Arnit_1231 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase Arnit_1234 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Arnit_1239 ENOG4105F1N DNA alkylation repair Arnit_1240 ENOG4108Z66 YbaK ebsC protein Arnit_1241 ENOG4105C7I Dehydrogenase Arnit_1246 ENOG4105BZU Histidine kinase Arnit_1247 ENOG4105CGD Nad-dependent epimerase dehydratase Arnit_1248 ENOG4105F1S paraquat-inducible protein a Arnit_1249 ENOG4105F1S paraquat-inducible protein a Arnit_1250 ENOG4105DY2 Paraquat-inducible protein b Arnit_1252 ENOG4105JXB ankyrin repeat-containing protein Arnit_1256 ENOG4105BZU Histidine kinase Arnit_1257 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Arnit_1262 ENOG4105SKE transcriptional Regulator LysR family Arnit_1267 ENOG4105Y49 secretion protein, HlyD family Arnit_1268 ENOG4105ZQC membrane protein AaeX Arnit_1271 ENOG41090MY MarR family Transcriptional regulator Arnit_1277 ENOG4105DZ1 carboxypeptidase Arnit_1278 ENOG4108URH decarboxylase Arnit_1279 ENOG4105E7W lamb ycsf family protein Arnit_1282 ENOG4108STX response regulator Arnit_1283 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Arnit_1285 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Arnit_1286 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Arnit_1288 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Arnit_1290 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Arnit_1291 ENOG4105CFM UPF0317 protein Arnit_1293 ENOG41080BE Methyl-accepting chemotaxis sensory transducer Arnit_1294 ENOG4105E7W lamb ycsf family protein Arnit_1295 ENOG4105P4J Allophanate hydrolase, subunit 1 Arnit_1296 ENOG4107R7A Allophanate hydrolase subunit 2 Arnit_1298 ENOG4105C1J atp-dependent rna helicase Arnit_1299 ENOG4106TD9 Diguanylate cyclase Arnit_1300 ENOG41085KW ppic-type peptidyL-prolyl cis-trans isomerase Arnit_1302 ENOG4105DCI Phosphohydrolase Arnit_1304 ENOG4108IAB Phoh family Arnit_1305 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) Arnit_1306 ENOG4105VEQ Cold shock protein Arnit_1314 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Arnit_1316 ENOG4105F38 ABC transporter, permease Arnit_1318 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Arnit_1319 ENOG4107RUE extracellular solute-binding protein family 1 Arnit_1320 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) Arnit_1322 ENOG4105EYW Ion transport protein Arnit_1326 ENOG4105CVE Lytic murein transglycosylase Arnit_1328 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Arnit_1331 ENOG4105BZU Histidine kinase Arnit_1332 ENOG4105BZ1 (ABC) transporter Arnit_1334 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 Arnit_1337 ENOG4105DR5 peptidase Arnit_1339 ENOG4105CDY transcriptional regulatory protein Arnit_1346 ENOG4107QPN acyl-Coa dehydrogenase Arnit_1347 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Arnit_1348 ENOG4105CHU acetyl-coa acetyltransferase Arnit_1349 ENOG4108IQE Amp-dependent synthetase and ligase Arnit_1350 ENOG4107QIJ Aconitate hydratase 2 Arnit_1352 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Arnit_1353 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component Arnit_1354 ENOG4105BZ7 extracellular solute-binding protein family 1 Arnit_1355 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Arnit_1356 ENOG4105E98 transcriptional regulator DeoR family Arnit_1360 ENOG4105E3S small subunit Arnit_1361 ENOG4105DPX Hydrogenase, large subunit Arnit_1364 ENOG4108P97 Arnit_1365 ENOG4105E3S small subunit Arnit_1366 ENOG4105DPX Hydrogenase, large subunit Arnit_1367 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit Arnit_1368 ENOG4108USZ hydrogenase Arnit_1371 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_1379 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) Arnit_1380 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF Arnit_1381 ENOG4105CQS hydrogenase expression formation protein HypD Arnit_1382 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Arnit_1383 ENOG4105C45 hydrogenase expression formation protein (HypE) Arnit_1384 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) Arnit_1385 ENOG4105BZU Histidine kinase Arnit_1387 ENOG4105C32 Amino acid ABC transporter (Permease) Arnit_1388 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Arnit_1389 ENOG4105C0Z ABC transporter Arnit_1390 ENOG4108IV0 ABC, transporter Arnit_1396 ENOG4105C25 Primosomal protein n' Arnit_1397 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) Arnit_1398 ENOG4105BZU Histidine kinase Arnit_1401 ENOG4105CAK Cell division ATP-binding protein ftsE Arnit_1402 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Arnit_1404 ENOG4105C34 Pseudouridine synthase Arnit_1405 ENOG4105CNI cell division protein FtsW Arnit_1406 ENOG4105CYW agmatinase Arnit_1410 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Arnit_1411 ENOG4105NBK UPF0345 protein Arnit_1415 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Arnit_1416 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Arnit_1417 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Arnit_1420 ENOG4105E5Q amino acid AbC transporter Arnit_1421 ENOG4105EAB amino acid AbC transporter Arnit_1422 ENOG4107QSE Dipeptidase Arnit_1425 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Arnit_1426 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Arnit_1427 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Arnit_1428 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Arnit_1429 ENOG4108ZT0 50S ribosomal protein l17 Arnit_1430 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Arnit_1431 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Arnit_1434 ENOG4105VMP Transcriptional regulator Arnit_1441 ENOG410829K Lysine exporter protein (Lyse ygga) Arnit_1444 ENOG41082IR Excinuclease ABC C subunit domain protein Arnit_1445 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) Arnit_1448 ENOG4108VD1 dedA family Arnit_1452 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) Arnit_1457 ENOG4108URH decarboxylase Arnit_1458 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) Arnit_1459 ENOG4108J5H Homocysteine s-methyltransferase Arnit_1461 ENOG4105N14 lysine exporter protein LysE YggA Arnit_1467 ENOG4105CH5 extracellular solute-binding protein, family 7 Arnit_1468 ENOG4105C5H ABC transporter Arnit_1471 ENOG4105DWV Homoserine O-trans-acetylase Arnit_1476 ENOG4105CVR type I restriction-modification system Arnit_1480 ENOG4105D06 uba thif-type nad fad binding protein Arnit_1481 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Arnit_1506 ENOG4107YTP response regulator receiver protein Arnit_1513 ENOG4108JJA ABC, transporter Arnit_1516 ENOG41065U4 response regulator Arnit_1517 ENOG4105D5K Hemolysin activator protein Arnit_1518 ENOG4105CKT filamentous hemagglutinin Arnit_1520 ENOG4105DEN Luciferase family Arnit_1522 ENOG4105VAW lrga family Arnit_1523 ENOG41067MG lrgb family Arnit_1525 ENOG4107WZZ SMC domain protein Arnit_1537 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) Arnit_1540 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Arnit_1542 ENOG4105MKU Transcriptional regulator Arnit_1545 ENOG4105FQT Arnit_1551 ENOG4105D49 3-dehydroquinate synthase Arnit_1553 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Arnit_1554 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Arnit_1556 ENOG4108RIR Molybdenum cofactor biosynthesis protein Arnit_1557 ENOG4105C8P )-transporter Arnit_1559 ENOG4105C98 muts2 protein Arnit_1560 ENOG4105D64 Mechanosensitive ion channel Arnit_1562 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Arnit_1568 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Arnit_1571 ENOG4105I93 response regulator Arnit_1572 ENOG4105DEF Extracellular solute-binding protein, family 5 Arnit_1573 ENOG4105BZU Histidine kinase Arnit_1575 ENOG4107QY8 reductase Arnit_1577 ENOG4105DN9 Na H antiporter Arnit_1583 ENOG4105KVH Transcriptional regulator Arnit_1585 ENOG4105NF4 modulator of drug activity Arnit_1586 ENOG4108DBC nitroreductase Arnit_1587 ENOG4105EE1 crotonyl-CoA reductase Arnit_1593 ENOG4108I6A alcohol dehydrogenase Arnit_1594 ENOG4108RCM Nitroreductase Arnit_1595 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_1598 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) Arnit_1600 ENOG4105C5H ABC transporter Arnit_1604 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Arnit_1608 ENOG4105XJC Two component transcriptional regulator (Winged helix family Arnit_1615 ENOG4105CIN aminoacyl-histidine dipeptidase Arnit_1616 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Arnit_1617 ENOG4105CRE cytochrome C Arnit_1618 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) Arnit_1619 ENOG4105BZU Histidine kinase Arnit_1620 ENOG4105C5X domain protein Arnit_1621 ENOG4105ED9 Protein of unknown function (DUF455) Arnit_1623 ENOG4105BZU Histidine kinase Arnit_1624 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) Arnit_1626 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Arnit_1630 ENOG4105CT4 transporter Arnit_1632 ENOG4107FW0 short-chain dehydrogenase reductase Arnit_1633 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Arnit_1635 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Arnit_1636 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Arnit_1638 ENOG4105BZU Histidine kinase Arnit_1640 ENOG4108UMN azlc family Arnit_1641 ENOG4105KMT branched-chain amino acid Arnit_1645 ENOG4108Z0R Transferase Arnit_1647 ENOG4105KQC Competence protein Arnit_1648 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) Arnit_1650 ENOG4105CDH Citrulline--aspartate ligase Arnit_1652 ENOG4108I0Q anthranilate phosphoribosyltransferase Arnit_1654 ENOG4108IUZ ABC transporter Arnit_1656 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) Arnit_1658 ENOG4105C2M dna polymerase I Arnit_1663 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Arnit_1664 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Arnit_1665 ENOG4105D4P Coproporphyrinogen iii oxidase Arnit_1666 ENOG4105DBV ornithine carbamoyltransferase Arnit_1673 ENOG4105D52 delta-aminolevulinic acid dehydratase Arnit_1675 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) Arnit_1682 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein Arnit_1711 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase Arnit_1712 ENOG4105D9Q decarboxylase (Beta subunit) Arnit_1713 ENOG4107QSA Oxaloacetate decarboxylase Arnit_1718 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Arnit_1720 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 Arnit_1725 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Arnit_1727 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) Arnit_1728 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Arnit_1730 ENOG4105EEI dihydropteroate synthase Arnit_1733 ENOG4105CFH Aspartokinase Arnit_1734 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Arnit_1735 ENOG4105CSA Coproporphyrinogen iii oxidase Arnit_1736 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Arnit_1737 ENOG4105DGW oligopeptidase A Arnit_1740 ENOG4108EU4 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Arnit_1747 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Arnit_1755 ENOG4105D9P serine threonine protein kinase Arnit_1756 ENOG4108WC9 type VI secretion system effector, hcp1 family Arnit_1767 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Arnit_1768 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) Arnit_1769 ENOG4105BZU Histidine kinase Arnit_1770 ENOG4105CBS Chea signal transduction histidine kinase Arnit_1771 ENOG4108VYJ response regulator receiver protein Arnit_1772 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Arnit_1774 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) Arnit_1776 ENOG4105C12 Phosphoribosylglycinamide synthetase Arnit_1778 ENOG4105CHH sulfate transporter Arnit_1779 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Arnit_1781 ENOG4105CNU cell division protein FtsK Arnit_1782 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Arnit_1783 ENOG4108ZP8 Acetolactate synthase small subunit Arnit_1784 ENOG4105C7K acetolactate synthase Arnit_1786 ENOG4105C9X ppx gppa phosphatase Arnit_1787 ENOG4108VTU Cdp-alcohol phosphatidyltransferase Arnit_1790 ENOG4105K63 Thioredoxin Arnit_1791 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Arnit_1793 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_1795 ENOG4105C26 Dehydrogenase Arnit_1796 ENOG4108IV0 ABC, transporter Arnit_1797 ENOG4105C0Z ABC transporter Arnit_1798 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Arnit_1799 ENOG4105C32 Amino acid ABC transporter (Permease) Arnit_1805 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Arnit_1818 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) Arnit_1819 ENOG4105CVM Molybdenum cofactor synthesis domain protein Arnit_1823 ENOG4105CGY Dna recombination protein Arnit_1824 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 Arnit_1826 ENOG4107YD3 Thioesterase Arnit_1830 ENOG4107QW4 alcohol dehydrogenase Arnit_1832 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_1833 ENOG4105CPC Aldo Keto reductase Arnit_1836 ENOG41080BB Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) Arnit_1837 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Arnit_1839 ENOG41081FY multiple antibiotic resistance (MarC)-related Arnit_1840 ENOG4108K7V UPF0284 protein Arnit_1841 ENOG4105CUV Homoserine Kinase Arnit_1842 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase Arnit_1843 ENOG4105CIH Imidazole acetol-phosphate transaminase Arnit_1845 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Arnit_1846 ENOG4105EHG Permease protein Arnit_1847 ENOG4108JJB ABC transporter Arnit_1849 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Arnit_1852 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Arnit_1853 ENOG4105I08 Pseudouridine synthase Arnit_1855 ENOG4105M15 transport protein ExbD Arnit_1856 ENOG4105M8K biopolymer transport protein Arnit_1858 ENOG4105XJC Two component transcriptional regulator (Winged helix family Arnit_1861 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Arnit_1862 ENOG4105CIY formyltetrahydrofolate deformylase Arnit_1863 ENOG4105C6K Malic enzyme Arnit_1865 ENOG4105E2X shikimate dehydrogenase Arnit_1869 ENOG4108UHV Lipoprotein Arnit_1870 ENOG4106032 Glutathionylspermidine synthase Arnit_1871 ENOG41080BE Methyl-accepting chemotaxis sensory transducer Arnit_1873 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) Arnit_1874 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Arnit_1875 ENOG4105C4K Nad synthetase Arnit_1879 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) Arnit_1881 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Arnit_1882 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) Arnit_1884 ENOG4107VQW regulatoR Arnit_1887 ENOG4105C8J )-transporter Arnit_1891 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) Arnit_1892 ENOG4105C5W Aldolase Arnit_1895 ENOG4105DJI Methylaspartate mutase, E subunit Arnit_1897 ENOG4105CEY Amp-dependent synthetase and ligase Arnit_1898 ENOG4105VBD cytochrome C, class I Arnit_1900 ENOG4105BZU Histidine kinase Arnit_1905 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Arnit_1907 ENOG410841J DNA-binding protein Hu Arnit_1911 ENOG4105BZU Histidine kinase Arnit_1912 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Arnit_1917 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Arnit_1918 ENOG4105D60 lipoprotein releasing system transmembrane protein Arnit_1921 ENOG4105E9K Isocitrate dehydrogenase Arnit_1922 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Arnit_1925 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Arnit_1927 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Arnit_1929 ENOG4105DVC DnaJ domain protein Arnit_1930 ENOG4105KNI merR family transcriptional Regulator Arnit_1931 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Arnit_1932 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Arnit_1934 ENOG4105C7H Helicase, RecD TraA family Arnit_1936 ENOG4105K89 arsenate reductase Arnit_1938 ENOG4105D00 flagellar biosynthetic protein flhB Arnit_1940 ENOG4105CJN penicillin-binding protein Arnit_1941 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_1942 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor Arnit_1943 ENOG4107RP9 extracellular solute-binding protein, family 3 Arnit_1944 ENOG4105CN7 Flagellar biosynthetic protein FliP Arnit_1945 ENOG41080BE Methyl-accepting chemotaxis sensory transducer Arnit_1945 ENOG41080BE Methyl-accepting chemotaxis sensory transducer Arnit_1950 ENOG4105KY5 gCN5-related N-acetyltransferase Arnit_1951 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) Arnit_1954 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase Arnit_1955 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Arnit_1956 ENOG4105K6T rare lipoprotein A Arnit_1957 ENOG4105E9H Lytic Murein transglycosylase Arnit_1958 ENOG4105F8V Hydrolase, tatD family Arnit_1960 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) Arnit_1961 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) Arnit_1962 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Arnit_1964 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Arnit_1965 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Arnit_1966 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Arnit_1967 ENOG4105CUT histidyl-tRNA synthetase Arnit_1968 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) Arnit_1969 ENOG4105D7W serine acetyltransferase Arnit_1971 ENOG4105C1J atp-dependent rna helicase Arnit_1972 ENOG4107QM5 aconitate hydratase Arnit_1973 ENOG4105D64 Mechanosensitive ion channel Arnit_1974 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Arnit_1977 ENOG4108JU6 CBS domain protein Arnit_1981 ENOG4105FCD Major Facilitator Arnit_1983 ENOG4105DR4 Methyltransferase Arnit_1984 ENOG4105VFU Rna-binding protein Arnit_1988 ENOG4105CK2 sodium dicarboxylate symporter Arnit_1989 ENOG4108594 Permease of the drug metabolite transporter Arnit_1990 ENOG4108JQ1 Dehydrogenase Arnit_1992 ENOG4107RY6 amino acid Arnit_1995 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein Arnit_1998 ENOG4108VP3 Lysine exporter protein (LysE YggA) Arnit_2002 ENOG4105D3R alkyl hydroperoxide reductase Arnit_2004 ENOG4105DB1 molybdopterin oxidoreductase Arnit_2006 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Arnit_2008 ENOG4105E3W Two component transcriptional regulator (Winged helix family Arnit_2009 ENOG4105VEQ Cold shock protein Arnit_2011 ENOG4105H9W Short-chain dehydrogenase reductase Sdr Arnit_2014 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Arnit_2017 ENOG4108KN0 Choline kinase Arnit_2021 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Arnit_2024 ENOG4105FE9 pseudouridine synthase Arnit_2027 ENOG4107TSN permease Arnit_2038 ENOG4105EFI regulatoR Arnit_2039 ENOG4105BZU Histidine kinase Arnit_2040 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_2060 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Arnit_2062 ENOG4105DN9 Na H antiporter Arnit_2063 ENOG4108IYU L-aspartate oxidase Arnit_2067 ENOG41076HS cation diffusion facilitator family transporter Arnit_2068 ENOG4105F8J Adenylate Guanylate cyclase Arnit_2071 ENOG4105C5H ABC transporter Arnit_2072 ENOG4105KTH gatB Yqey Arnit_2073 ENOG4106TD9 Diguanylate cyclase Arnit_2077 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) Arnit_2085 ENOG4105E1F short-chain dehydrogenase reductase Arnit_2086 ENOG4107S6Z Na H antiporter Arnit_2087 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) Arnit_2088 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Arnit_2089 ENOG4106H78 methyltransferase Arnit_2092 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) Arnit_2094 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Arnit_2095 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Arnit_2098 ENOG4105BZU Histidine kinase Arnit_2099 ENOG4105NQN cytochrome C Arnit_2103 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Arnit_2105 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_2112 ENOG410829K Lysine exporter protein (Lyse ygga) Arnit_2114 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Arnit_2116 ENOG41080V7 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Arnit_2119 ENOG4108RMU ferritin dps family protein Arnit_2120 ENOG4108RAC Rubrerythrin Arnit_2122 ENOG4105CJR Integral membrane protein (MviN Arnit_2123 ENOG4105BZ1 (ABC) transporter Arnit_2124 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Arnit_2127 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Arnit_2128 ENOG4105CAN Short-chain dehydrogenase reductase Sdr Arnit_2129 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Arnit_2130 ENOG4105DZP Membrane-associated zinc metalloprotease Arnit_2131 ENOG4105DFA alanine racemase domain protein Arnit_2135 ENOG4105DK0 Indole-3-glycerol phosphate synthase Arnit_2137 ENOG4105QTX Pfam:UPF0153 Arnit_2138 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) Arnit_2140 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein Arnit_2141 ENOG4105C7K acetolactate synthase Arnit_2158 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) Arnit_2159 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase Arnit_2160 ENOG4105DJV ribulose-phosphate 3-epimerase Arnit_2161 ENOG4105HDD phospholipase Arnit_2163 ENOG4105BZU Histidine kinase Arnit_2168 ENOG4105BZU Histidine kinase Arnit_2170 ENOG4107VIJ nudix hydrolase Arnit_2173 ENOG4105XJC Two component transcriptional regulator (Winged helix family Arnit_2174 ENOG4108VPT UPF0234 protein Arnit_2175 ENOG4105M08 Membrane Arnit_2177 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) Arnit_2178 ENOG4105C7N Xanthine uracil vitamin C permease Arnit_2181 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) Arnit_2182 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Arnit_2183 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Arnit_2186 ENOG41088CC tellurite resistance protein tehB Arnit_2187 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein Arnit_2188 ENOG4105E4R Precorrin-3B C17-methyltransferase Arnit_2189 ENOG4108P62 biosynthesis protein (CbiG) Arnit_2190 ENOG4105CIA precorrin-4 C(11)-methyltransferase Arnit_2191 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase Arnit_2192 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) Arnit_2196 ENOG4107PPM cobalt chelatase Arnit_2199 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) Arnit_2200 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Arnit_2204 ENOG4108M60 Transcriptional regulator Arnit_2206 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Arnit_2208 ENOG4105WPR Transcriptional regulator, ARAC family Arnit_2210 ENOG4107SQU synthase Arnit_2217 ENOG4107ZSV Receptor Arnit_2218 ENOG4108M1M outer membrane lipoprotein-sorting protein Arnit_2221 ENOG4105CX6 glutaminyL-tRNA synthetase Arnit_2229 ENOG41082XB radical SAM domain protein Arnit_2230 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Arnit_2232 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Arnit_2235 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Arnit_2236 ENOG4107SVH Potassium channel protein Arnit_2237 ENOG4105VB9 50S ribosomal protein l28 Arnit_2239 ENOG4105DKP glycosyl transferase, family 9 Arnit_2240 ENOG4107RJ7 Glycosyl transferase (Group 1 Arnit_2245 ENOG4105DKP glycosyl transferase, family 9 Arnit_2246 ENOG4105M5K heptosyltransferase Arnit_2247 ENOG4107BJW polysaccharide deacetylase Arnit_2248 ENOG4105CPK Glycosyl transferase (Group 1 Arnit_2250 ENOG4106WTF Glycosyl transferase, family 2 Arnit_2252 ENOG4105D16 lipopolysaccharide heptosyltransferase i Arnit_2254 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding Arnit_2255 ENOG4105BZ8 glutamate synthase Arnit_2256 ENOG4105CBC glutamate synthase Arnit_2257 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Arnit_2258 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Arnit_2260 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Arnit_2262 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Arnit_2265 ENOG4105C1J atp-dependent rna helicase Arnit_2268 ENOG4105BZU Histidine kinase Arnit_2271 ENOG4107R7Y intracellular protease Pfpi family Arnit_2272 ENOG4107HP6 Transcriptional regulator Arnit_2276 ENOG4105CPI Metal Dependent Phosphohydrolase Arnit_2278 ENOG4105C2W permease Arnit_2279 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Arnit_2280 ENOG4105CKW Inner membrane protein yedI Arnit_2281 ENOG4105C0R drug resistance transporter emrb qaca subfamily Arnit_2282 ENOG4105CW7 secretion protein, HlyD family Arnit_2283 ENOG4105ETP RND efflux system, outer membrane lipoprotein Arnit_2286 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) Arnit_2287 ENOG4105M7K Involved in the transcription termination process (By similarity) Arnit_2288 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Arnit_2289 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase Arnit_2293 ENOG4105DJP Membrane Arnit_2294 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Arnit_2299 ENOG4105GVR general secretion pathway protein D Arnit_2300 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Arnit_2301 ENOG4105DX0 Hemolysin A Arnit_2303 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) Arnit_2304 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Arnit_2306 ENOG4105CQB FAD linked oxidase domain protein Arnit_2307 ENOG4107S2Z UPF0761 membrane protein Arnit_2317 ENOG4105CJ1 ABC, transporter Arnit_2322 ENOG4105CHR reductase Arnit_2323 ENOG4105C84 Histidine ammonia-lyase Arnit_2327 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Arnit_2332 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) Arnit_2333 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Arnit_2334 ENOG4108YZY peptidylprolyl cis-trans isomerase Arnit_2336 ENOG4105UYK outer membrane protein a Arnit_2337 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) Arnit_2339 ENOG4105M8F Biopolymer transport protein exbD tolR Arnit_2340 ENOG4105E02 MotA TolQ exbB proton channel Arnit_2341 ENOG41082MC Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Arnit_2342 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Arnit_2343 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Arnit_2344 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Arnit_2345 ENOG4105PQH F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Arnit_2346 ENOG4105YF2 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) Arnit_2348 ENOG4105FA0 parb-like partition protein Arnit_2349 ENOG4107QJE Chromosome Partitioning Protein Arnit_2352 ENOG4105BZU Histidine kinase Arnit_2353 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Arnit_2354 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Arnit_2355 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Arnit_2356 ENOG4105K46 50S ribosomal protein l27 Arnit_2357 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Arnit_2358 ENOG4105KME endoribonuclease L-psp Arnit_2359 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Arnit_2361 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Arnit_2362 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Arnit_2363 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Arnit_2364 ENOG4105VYW UPF0251 protein Arnit_2365 ENOG4105D0M Protease HtpX homolog Arnit_2366 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Arnit_2367 ENOG4105CBX hi0933 family Arnit_2368 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Arnit_2370 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Arnit_2371 ENOG4108512 Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Arnit_2372 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Arnit_2373 ENOG4105VG0 50S ribosomal protein l34 Arnit_2374 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Arnit_2375 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Arnit_2379 ENOG4106TD9 Diguanylate cyclase Arnit_2382 ENOG4105E0X reductase Arnit_2383 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase Arnit_2384 ENOG4105K56 Transcriptional regulator Arnit_2386 ENOG4109045 doxx family Arnit_2389 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Arnit_2391 ENOG4108ISG Major Facilitator Arnit_2392 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_2395 ENOG4105C94 Transporter Arnit_2396 ENOG4107YB6 acetyltransferase, (GNAT) family Arnit_2397 ENOG4105C6Z Gluconate Arnit_2398 ENOG4108ZX5 transcriptional regulator Arnit_2400 ENOG4105VCH membrane Arnit_2402 ENOG4105DC1 bifunctional purine biosynthesis protein purh Arnit_2404 ENOG4105CPF Cell wall formation (By similarity) Arnit_2406 ENOG4107QIK phosphoribosylformylglycinamidine synthase Arnit_2408 ENOG4105DR5 peptidase Arnit_2409 ENOG4105CJW magnesium transporter Arnit_2411 ENOG4105EUJ GTP cyclohydrolase i Arnit_2412 ENOG4105D7Q type ii secretion system Arnit_2413 ENOG4107QHF type ii secretion system protein e Arnit_2416 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Arnit_2417 ENOG4105C0P Mg chelatase subunit ChlI Arnit_2418 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Arnit_2419 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Arnit_2420 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Arnit_2422 ENOG4105CSR polyphosphate kinase 2 Arnit_2423 ENOG4105CSR polyphosphate kinase 2 Arnit_2427 ENOG4108TGY Glutathione S-transferase Arnit_2428 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_2437 ENOG4105CAF HipA N-terminal domain protein Arnit_2439 ENOG4105BZU Histidine kinase Arnit_2440 ENOG4105C1J atp-dependent rna helicase Arnit_2442 ENOG4107Z9R response regulator Arnit_2443 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_2448 ENOG4107K9B ferrous iron transport protein Arnit_2449 ENOG4105CE1 Ferrous iron transport protein b Arnit_2451 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate Arnit_2452 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Arnit_2456 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Arnit_2457 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Arnit_2458 ENOG4105F4G Membrane Arnit_2463 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Arnit_2464 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) Arnit_2465 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) Arnit_2466 ENOG4105CFH Aspartokinase Arnit_2467 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) Arnit_2468 ENOG4108JPW Aminotransferase Arnit_2469 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase Arnit_2474 ENOG4105D7B Flagellar biosynthesis protein flha Arnit_2476 ENOG4108JIR Flagellum-specific ATP synthase Arnit_2478 ENOG4105D00 flagellar biosynthetic protein flhB Arnit_2481 ENOG4108ZC9 flagellar basal-body rod protein flgc Arnit_2484 ENOG4107R21 site-determining protein Arnit_2485 ENOG4105FZW flagellar biosynthesis regulator FlhF Arnit_2488 ENOG4105YKR Arnit_2491 ENOG4105DD5 Flagellar motor switch protein Arnit_2495 ENOG4108JQA flagellar Arnit_2498 ENOG4105DD5 Flagellar motor switch protein Arnit_2500 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Arnit_2501 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) Arnit_2502 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Arnit_2503 ENOG4105KTQ flagellar basal-body rod protein Arnit_2505 ENOG4108VYJ response regulator receiver protein Arnit_2506 ENOG4105CGA flagellar basal-body rod protein FlgG Arnit_2509 ENOG4105V3S An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Arnit_2510 ENOG4105VB6 UPF0109 protein Arnit_2511 ENOG4105K5M 30s ribosomal protein S16 Arnit_2512 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY Arnit_2513 ENOG4105EI2 Pseudouridine synthase Arnit_2516 ENOG4105EGD dinuclear metal center protein, YbgI family Arnit_2517 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit Arnit_2518 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Arnit_2519 ENOG4105CEY Amp-dependent synthetase and ligase Arnit_2520 ENOG4105FR1 rard protein Arnit_2526 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Arnit_2527 ENOG4105CV1 Transketolase (EC 2.2.1.1) Arnit_2531 ENOG4105C42 Type I secretion membrane fusion protein (HlyD Arnit_2532 ENOG4108JJA ABC, transporter Arnit_2534 ENOG4105I93 response regulator Arnit_2539 ENOG4105C5E polysaccharide biosynthesis protein Arnit_2540 ENOG4105ESV Glycosyl transferase, family 4 Arnit_2542 ENOG4105CGN Glycosyl transferase (Group 1 Arnit_2543 ENOG4105CAQ asparagine synthetase Arnit_2545 ENOG4105CG5 Glycosyl transferase (Group 1 Arnit_2546 ENOG4105BZ1 (ABC) transporter Arnit_2547 ENOG4105CAQ asparagine synthetase Arnit_2548 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Arnit_2552 ENOG4105C1B dTDP-glucose 4-6-dehydratase Arnit_2559 ENOG4105C1B dTDP-glucose 4-6-dehydratase Arnit_2560 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase Arnit_2561 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) Arnit_2565 ENOG4105CAQ asparagine synthetase Arnit_2566 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Arnit_2567 ENOG4105CMR udp-glucose 4-epimerase Arnit_2568 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Arnit_2569 ENOG4105J5G Transferase hexapeptide repeat containing protein Arnit_2570 ENOG4107R5Z Oxidoreductase domain protein Arnit_2571 ENOG4107QQG Dehydrogenase Arnit_2576 ENOG4105CMR udp-glucose 4-epimerase Arnit_2577 ENOG4105C01 Dihydroxy-acid dehydratase Arnit_2578 ENOG4105C0H protease Arnit_2579 ENOG4105E3W Two component transcriptional regulator (Winged helix family Arnit_2580 ENOG4105DHQ Histidine kinase Arnit_2581 ENOG4105CFP Peptidase U32 Arnit_2582 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Arnit_2583 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Arnit_2587 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Arnit_2588 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Arnit_2589 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Arnit_2590 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_2591 ENOG4105F27 Major Facilitator Arnit_2594 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Arnit_2597 ENOG4108NIW Leucine export protein LeuE Arnit_2598 ENOG4108UPT UPF0178 protein Arnit_2602 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Arnit_2603 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) Arnit_2604 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) Arnit_2605 ENOG4107QSN dihydrolipoamide acetyltransferase Arnit_2606 ENOG4107QN2 dihydrolipoyl dehydrogenase Arnit_2612 ENOG4105G01 cobalamin (vitamin B12) biosynthesis CbiM protein Arnit_2614 ENOG4105K9H YciI-like protein Arnit_2616 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Arnit_2617 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Arnit_2618 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Arnit_2619 ENOG4108VZM 50s ribosomal protein L10 Arnit_2620 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) Arnit_2621 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Arnit_2622 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) Arnit_2624 ENOG41086AR 50S ribosomal protein L33 Arnit_2625 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Arnit_2626 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Arnit_2627 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Arnit_2628 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Arnit_2629 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Arnit_2630 ENOG4108JQC penicillin-binding protein 1A Arnit_2631 ENOG4105C5F glutamine synthetase Arnit_2632 ENOG4107RVV histidinol phosphate phosphatase, hisj family Arnit_2633 ENOG4108ZEX molybdopterin converting factor, subunit 2 Arnit_2635 ENOG4108XUR Pfam:DUF178 Arnit_2636 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Arnit_2637 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Arnit_2638 ENOG4105CNI cell division protein FtsW Arnit_2639 ENOG4105CJN penicillin-binding protein Arnit_2640 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Arnit_2645 ENOG4105DDQ anthranilate synthase Arnit_2647 ENOG4105F38 ABC transporter, permease Arnit_2648 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Arnit_2650 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) Arnit_2651 ENOG4105C87 Aminotransferase class I and II Arnit_2652 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Arnit_2653 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Arnit_2654 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Arnit_2655 ENOG4105GKE subunit e Arnit_2657 ENOG4105BZN citrate synthase Arnit_2659 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) Arnit_2661 ENOG4107UFS subunit j Arnit_2662 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Arnit_2664 ENOG4105C8S subunit m Arnit_2665 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Arnit_2666 ENOG4108S24 Fumarate reduCtase Arnit_2667 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) Arnit_2668 ENOG4105E33 succinate dehydrogenase Arnit_2674 ENOG4107XWZ ferric uptake regulator Arnit_2684 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) Arnit_2687 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha Arnit_2690 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b Arnit_2695 ENOG4105VSH 4-oxalocrotonate tautomerase Arnit_2697 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) Arnit_2698 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) Arnit_2700 ENOG41081FY multiple antibiotic resistance (MarC)-related Arnit_2701 ENOG4105E5Q amino acid AbC transporter Arnit_2702 ENOG4106PMH Extracellular solute-binding protein family 3 Arnit_2707 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Arnit_2710 ENOG4107YTP response regulator receiver protein Arnit_2711 ENOG4105BZU Histidine kinase Arnit_2712 ENOG4105C9U ATP-dependent DNA helicase RecQ Arnit_2714 ENOG4105BZU Histidine kinase Arnit_2717 ENOG4105UEI Transcriptional Regulator AraC Family Arnit_2718 ENOG4105C09 Bile acid Arnit_2719 ENOG4105C09 Bile acid Arnit_2720 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Arnit_2721 ENOG4108W2Y isochorismatase Arnit_2722 ENOG4105C5I Dehydrogenase Arnit_2727 ENOG4105CR4 methylisocitrate lyase Arnit_2728 ENOG4105BZN citrate synthase Arnit_2729 ENOG4108I0Z Aconitate hydratase Arnit_2730 ENOG4105C7F AcnD-accessory protein PrpF Arnit_2731 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) Arnit_2732 ENOG4105CHJ isochorismatase hydrolase Arnit_2733 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Arnit_2735 ENOG4107QMP dna polymerase iii subunits gamma and tau Arnit_2736 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Arnit_2737 ENOG4105C08 Histidine kinase Arnit_2738 ENOG4105D01 (LipO)protein Arnit_2739 ENOG4108UMI ABC transporter, permease Arnit_2740 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Arnit_2743 ENOG4105CFI type iii restriction protein res subunit Arnit_2745 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Arnit_2746 ENOG4105D3R alkyl hydroperoxide reductase Arnit_2748 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Arnit_2750 ENOG4105YQ2 50s ribosomal protein l32 Arnit_2751 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Arnit_2752 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Arnit_2757 ENOG4105BZU Histidine kinase Arnit_2760 ENOG4105CXT aspartate transcarbamylase Arnit_2762 ENOG4105C8Y Acetylornithine aminotransferase Arnit_2766 ENOG4105CA9 Pyruvate kinase Arnit_2770 ENOG4107EFR Flavocytochrome c Arnit_2772 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_2777 ENOG4105BZU Histidine kinase Arnit_2778 ENOG4105XJC Two component transcriptional regulator (Winged helix family Arnit_2779 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Arnit_2780 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E Arnit_2782 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) Arnit_2784 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) Arnit_2785 ENOG4105DZG Dehydrogenase Arnit_2787 ENOG4105CJ1 ABC, transporter Arnit_2798 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Arnit_2801 ENOG4105K56 Transcriptional regulator Arnit_2803 ENOG4108SNK aliphatic sulfonates import ATP-binding protein SsuB Arnit_2810 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Arnit_2813 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Arnit_2815 ENOG4108IEG Formate dehydrogenase Alpha subunit Arnit_2816 ENOG41082UM UPF0102 protein Arnit_2817 ENOG4107R4J Chloride channel Arnit_2819 ENOG4105CKD glutathione-regulated potassium-efflux system protein Arnit_2820 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Arnit_2821 ENOG4107B2H carbonic anhydrase Arnit_2823 ENOG4105DVY radical SAM domain protein Arnit_2825 ENOG4105KB8 (LipO)protein Arnit_2826 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Arnit_2828 ENOG4105CHV Transcription elongation factor NusA Arnit_2829 ENOG4105C8N cysteinyl-tRNA synthetase Arnit_2831 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Arnit_2832 ENOG4108UUM single-stranded DNA-binding protein Arnit_2833 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) Arnit_2835 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Arnit_2836 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Arnit_2837 ENOG4105PXI polysaccharide deacetylase Arnit_2839 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_2840 ENOG4105EAB amino acid AbC transporter Arnit_2841 ENOG4105E5Q amino acid AbC transporter Arnit_2843 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Arnit_2844 ENOG4105DFU Cell wall formation (By similarity) Arnit_2846 ENOG4105CHM Aminotransferase Arnit_2851 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Arnit_2852 ENOG410855J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Arnit_2853 ENOG4105KUZ arsenate reductase Arnit_2856 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase Arnit_2858 ENOG4105EAC phosphoserine phosphatase Arnit_2859 ENOG4105GSH Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Arnit_2864 ENOG410829W Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Arnit_2866 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Arnit_2868 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) Arnit_2872 ENOG4105DTS flagellar hook-associated Arnit_2873 ENOG4105E1Q flagellar hook-associated protein Arnit_2873 ENOG4105E1Q flagellar hook-associated protein Arnit_2879 ENOG4105VS8 Flagellar biosynthetic protein fliq Arnit_2881 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) Arnit_2882 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Arnit_2883 ENOG4105EKE dihydroorotase Arnit_2884 ENOG4108YZA Nitrogen regulatory protein pii Arnit_2886 ENOG4108YZA Nitrogen regulatory protein pii Arnit_2890 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) Arnit_2891 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) Arnit_2895 ENOG4105DJ4 phosphatidylserine decarboxylase Arnit_2899 ENOG4105CFG Acts as a chaperone (By similarity) Arnit_2900 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Arnit_2901 ENOG4108122 heat-inducible transcription repressor Arnit_2910 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Arnit_2913 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) Arnit_2914 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Arnit_2915 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Arnit_2916 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Arnit_2919 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Arnit_2923 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) Arnit_2927 ENOG4105CMR udp-glucose 4-epimerase Arnit_2928 ENOG4105C30 Nad-dependent epimerase dehydratase Arnit_2929 ENOG4108HHA Transketolase Arnit_2930 ENOG4108IUS Transketolase Arnit_2932 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) Arnit_2933 ENOG4107RIQ Sulfate adenylate transferase Arnit_2935 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase Arnit_2942 ENOG4105DTI Phosphonopyruvate decarboxylase Arnit_2946 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR Arnit_2950 ENOG4105D2T synthase Arnit_2951 ENOG4105F0R Cytidylyltransferase Arnit_2952 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Arnit_2953 ENOG4105C5E polysaccharide biosynthesis protein Arnit_2955 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Arnit_2956 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Arnit_2960 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) Arnit_2964 ENOG4105E63 Pfam:DUF178 Arnit_2966 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Arnit_2967 ENOG4105C8S subunit m Arnit_2968 ENOG4105D65 subunit l Arnit_2969 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Arnit_2971 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Arnit_2972 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) Arnit_2976 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Arnit_2977 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Arnit_2978 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Arnit_2979 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Arnit_2980 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Arnit_2989 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) Arnit_2990 ENOG4105DAA L-lactate Arnit_2993 ENOG4107XC4 flavin reductase domain protein, FMN-binding Arnit_2994 ENOG4105C9Q fumarate hydratase class II Arnit_2997 ENOG4105DJG MaoC domain protein dehydratase Arnit_3002 ENOG4105BZU Histidine kinase Arnit_3003 ENOG4105WPN DNA integration recombination invertion protein Arnit_3005 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) Arnit_3006 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Arnit_3007 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Arnit_3010 ENOG4105BZU Histidine kinase Arnit_3011 ENOG4105ES5 Histidine kinase Arnit_3012 ENOG4108R6K riboflavin synthase, subunit alpha Arnit_3013 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Arnit_3016 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_3020 ENOG4106K80 Arnit_3021 ENOG4105CA0 peroxidase Arnit_3028 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Arnit_3029 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Arnit_3034 ENOG4105F8J Adenylate Guanylate cyclase Arnit_3037 ENOG4105D78 K07001 NTE family protein Arnit_3038 ENOG4105C0B DNA polymerase III (alpha subunit) Arnit_3039 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Arnit_3044 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Arnit_3045 ENOG41082DJ 30S ribosomal protein S21 Arnit_3046 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i Arnit_3050 ENOG4105HFZ Membrane Arnit_3053 ENOG4105NU9 Preprotein translocase subunit SecG Arnit_3054 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Arnit_3055 ENOG4107VCP Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Arnit_3057 ENOG4105D8G Major Facilitator superfamily Arnit_3058 ENOG4105BZU Histidine kinase Arnit_3059 ENOG410802Z Protein of unknown function (DUF328) Arnit_3060 ENOG4105K5B UPF0225 protein Arnit_3065 ENOG4105C7K acetolactate synthase Arnit_3066 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Arnit_3069 ENOG4105BZU Histidine kinase Arnit_3072 ENOG4105F6E Acyl-transferase Arnit_3078 ENOG4105CBX hi0933 family Arnit_3082 ENOG4105BZS acriflavin resistance protein Arnit_3083 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Arnit_3086 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family Arnit_3087 ENOG4105C6T cysteine synthase Arnit_3090 ENOG4105C11 sulfate adenylyltransferase), subunit 2 Arnit_3091 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) Arnit_3092 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) Arnit_3093 ENOG4105C9B Cysteine desulfurase Arnit_3096 ENOG4105ZAI Arnit_3097 ENOG4105DIN metallophosphoesterase Arnit_3098 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor Arnit_3099 ENOG4105C8Q Methyl-accepting chemotaxis Arnit_3106 ENOG4107Y70 Heat shock protein Arnit_3110 ENOG4105CI3 gtp-binding protein typa Arnit_3112 ENOG4105KSU Redox protein Arnit_3113 ENOG4105CSV Glutaminase Arnit_3118 ENOG4105EB3 Histidine kinase Arnit_3119 ENOG4108MRH transcriptional regulatory protein Arnit_3124 ENOG4107XPZ Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Arnit_3129 ENOG4107RN3 metallophosphoesterase Arnit_3132 ENOG4105CHH sulfate transporter Arnit_3136 ENOG41080IJ Diacylglycerol kinase Arnit_3142 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Arnit_3143 ENOG4105F3H Histidine kinase Arnit_3144 ENOG4105EN6 Membrane Arnit_3145 ENOG4105BZU Histidine kinase Arnit_3147 ENOG4107YTP response regulator receiver protein Arnit_3148 ENOG4108V3E phosphoribosylglycinamide formyltransferase Arnit_3149 ENOG410631K Membrane Arnit_3150 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)