locus-tag	class	description
APORC_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APORC_0002	COG0592	DNA-directed DNA polymerase activity
APORC_0003	COG0187	DNA topoisomerase II activity
APORC_0006	COG1238	metal cluster binding
APORC_0008	COG0500	methyltransferase
APORC_0016	COG0564	pseudouridine synthase activity
APORC_0017	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APORC_0018	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APORC_0019	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APORC_0022	COG0604	alcohol dehydrogenase
APORC_0023	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APORC_0024	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APORC_0026	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APORC_0026	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APORC_0027	COG0511	ligase activity, forming carbon-carbon bonds
APORC_0028	COG0439	Biotin carboxylase
APORC_0029	COG0513	Belongs to the DEAD box helicase family
APORC_0030	COG0306	phosphate transporter
APORC_0032	COG0367	asparagine synthase
APORC_0034	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
APORC_0036	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APORC_0036	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
APORC_0037	COG1187	pseudouridine synthase activity
APORC_0038	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APORC_0038	COG0517	IMP dehydrogenase activity
APORC_0040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APORC_0041	COG0107	imidazoleglycerol-phosphate synthase activity
APORC_0044	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APORC_0045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APORC_0046	COG0724	RNA recognition motif
APORC_0047	COG0745	RESPONSE REGULATOR receiver
APORC_0048	COG5002	protein histidine kinase activity
APORC_0052	COG2353	YceI-like domain
APORC_0053	COG0460	homoserine dehydrogenase
APORC_0054	COG0436	Aminotransferase
APORC_0056	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APORC_0057	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APORC_0058	COG0254	rRNA binding
APORC_0059	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APORC_0061	COG0109	protoheme IX farnesyltransferase activity
APORC_0063	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APORC_0064	COG4943	cyclic-guanylate-specific phosphodiesterase activity
APORC_0065	COG0573	inorganic phosphate transmembrane transporter activity
APORC_0067	COG0581	inorganic phosphate transmembrane transporter activity
APORC_0068	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APORC_0071	COG0745	RESPONSE REGULATOR receiver
APORC_0072	COG0642	Histidine kinase
APORC_0074	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APORC_0075	COG0315	cyclic pyranopterin monophosphate synthase activity
APORC_0079	COG1233	COG1233 Phytoene dehydrogenase and related
APORC_0080	COG3275	phosphorelay sensor kinase activity
APORC_0081	COG3279	Response regulator of the LytR AlgR family
APORC_0083	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APORC_0087	COG3040	lipid binding
APORC_0090	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APORC_0091	COG0587	DNA-directed DNA polymerase activity
APORC_0098	COG0693	protein deglycase activity
APORC_0101	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
APORC_0101	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APORC_0102	COG0504	CTP synthase activity
APORC_0103	COG0348	domain, Protein
APORC_0105	COG0237	dephospho-CoA kinase activity
APORC_0106	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APORC_0107	COG3852	Histidine kinase
APORC_0108	COG0745	RESPONSE REGULATOR receiver
APORC_0109	COG0446	pyridine nucleotide-disulphide oxidoreductase
APORC_0114	COG2353	YceI-like domain
APORC_0116	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
APORC_0117	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APORC_0118	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APORC_0120	COG0505	Belongs to the CarA family
APORC_0121	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
APORC_0123	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APORC_0123	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APORC_0125	COG0489	protein tyrosine kinase activity
APORC_0127	COG1917	Cupin 2, conserved barrel domain protein
APORC_0128	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APORC_0129	COG0456	acetyltransferase
APORC_0132	COG0140	phosphoribosyl-ATP diphosphatase activity
APORC_0132	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APORC_0137	COG1410	methionine synthase
APORC_0137	COG0646	methionine synthase
APORC_0141	COG1854	S-ribosylhomocysteine lyase activity
APORC_0144	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APORC_0149	COG0546	phosphoglycolate phosphatase activity
APORC_0152	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
APORC_0154	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APORC_0156	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APORC_0157	COG0352	thiamine-phosphate diphosphorylase activity
APORC_0158	COG0351	phosphomethylpyrimidine kinase
APORC_0158	COG0352	thiamine-phosphate diphosphorylase activity
APORC_0162	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
APORC_0170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APORC_0171	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APORC_0172	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APORC_0173	COG0268	Binds directly to 16S ribosomal RNA
APORC_0174	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APORC_0175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APORC_0176	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APORC_0177	COG0746	molybdenum cofactor guanylyltransferase activity
APORC_0181	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APORC_0182	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APORC_0184	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APORC_0191	COG0575	Belongs to the CDS family
APORC_0192	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APORC_0195	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APORC_0208	COG0840	transmembrane signaling receptor activity
APORC_0209	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APORC_0215	COG0640	Transcriptional regulator
APORC_0216	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APORC_0217	COG2059	Chromate
APORC_0220	COG0347	Belongs to the P(II) protein family
APORC_0222	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APORC_0223	COG1706	bacterial-type flagellum-dependent cell motility
APORC_0225	COG1987	bacterial-type flagellum assembly
APORC_0230	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
APORC_0236	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APORC_0238	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APORC_0239	COG0601	transmembrane transport
APORC_0240	COG0736	holo-[acyl-carrier-protein] synthase activity
APORC_0242	COG0786	glutamate:sodium symporter activity
APORC_0243	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APORC_0244	COG0646	methionine synthase
APORC_0244	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
APORC_0245	COG0560	Phosphoserine phosphatase
APORC_0247	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
APORC_0248	COG1393	Belongs to the ArsC family
APORC_0249	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APORC_0250	COG0343	queuine tRNA-ribosyltransferase activity
APORC_0255	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APORC_0256	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APORC_0257	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APORC_0258	COG3278	Belongs to the heme-copper respiratory oxidase family
APORC_0261	COG2010	Cytochrome c
APORC_0272	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APORC_0275	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APORC_0277	COG0157	Belongs to the NadC ModD family
APORC_0280	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
APORC_0282	COG0083	homoserine kinase activity
APORC_0284	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APORC_0285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APORC_0286	COG0779	Required for maturation of 30S ribosomal subunits
APORC_0287	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APORC_0287	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APORC_0290	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APORC_0291	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APORC_0292	COG0539	negative regulation of cytoplasmic translation
APORC_0292	COG1185	polyribonucleotide nucleotidyltransferase activity
APORC_0293	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APORC_0294	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APORC_0295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APORC_0295	COG0072	phenylalanine-tRNA ligase activity
APORC_0296	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APORC_0297	COG0537	adenosine 5'-monophosphoramidase activity
APORC_0300	COG0825	malonyl-CoA metabolic process
APORC_0301	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APORC_0302	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APORC_0306	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APORC_0308	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APORC_0309	COG0723	plastoquinol--plastocyanin reductase activity
APORC_0310	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APORC_0311	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APORC_0312	COG0210	DNA helicase
APORC_0313	COG0356	it plays a direct role in the translocation of protons across the membrane
APORC_0314	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APORC_0315	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APORC_0317	COG0336	Belongs to the RNA methyltransferase TrmD family
APORC_0318	COG0335	large ribosomal subunit rRNA binding
APORC_0319	COG0586	Pfam SNARE associated Golgi protein
APORC_0321	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APORC_0323	COG0251	oxidation-reduction process
APORC_0329	COG3328	transposase activity
APORC_0335	COG1840	ABC-type Fe3 transport system, periplasmic component
APORC_0336	COG0512	Glutamine amidotransferase of anthranilate synthase
APORC_0340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APORC_0341	COG0049	tRNA binding
APORC_0342	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APORC_0343	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APORC_0344	COG0497	DNA recombination
APORC_0345	COG0840	transmembrane signaling receptor activity
APORC_0345	COG0840	transmembrane signaling receptor activity
APORC_0348	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APORC_0350	COG0752	glycyl-tRNA synthetase alpha subunit
APORC_0351	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APORC_0353	COG1519	Transferase
APORC_0353	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APORC_0354	COG0564	pseudouridine synthase activity
APORC_0355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APORC_0356	COG0228	four-way junction DNA binding
APORC_0358	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APORC_0364	COG4786	Flagellar basal body rod
APORC_0365	COG1815	bacterial-type flagellum-dependent cell motility
APORC_0366	COG1766	The M ring may be actively involved in energy transduction
APORC_0367	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APORC_0369	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APORC_0371	COG1749	Flagellar hook protein flgE
APORC_0376	COG3951	Flagellar rod assembly protein muramidase FlgJ
APORC_0379	COG1419	protein localization to endoplasmic reticulum
APORC_0380	COG0455	bacterial-type flagellum organization
APORC_0382	COG1677	Flagellar hook-basal body complex protein FliE
APORC_0386	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APORC_0388	COG1157	protein secretion by the type III secretion system
APORC_0390	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APORC_0392	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APORC_0393	COG0482	sulfurtransferase activity
APORC_0394	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APORC_0395	COG0006	proline dipeptidase activity
APORC_0397	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APORC_0398	COG0402	S-adenosylhomocysteine deaminase activity
APORC_0399	COG0616	signal peptide processing
APORC_0400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APORC_0401	COG0280	phosphate acetyltransferase
APORC_0402	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APORC_0403	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APORC_0405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APORC_0407	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APORC_0409	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
APORC_0411	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APORC_0413	COG5002	protein histidine kinase activity
APORC_0423	COG0579	oxidoreductase
APORC_0424	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APORC_0428	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APORC_0429	COG0052	Belongs to the universal ribosomal protein uS2 family
APORC_0430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APORC_0431	COG1136	(ABC) transporter
APORC_0433	COG0194	GDP metabolic process
APORC_0434	COG2207	Transcriptional regulator
APORC_0434	COG4753	response regulator
APORC_0435	COG2217	Heavy metal translocating P-type atpase
APORC_0439	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APORC_0441	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APORC_0442	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APORC_0443	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APORC_0444	COG0352	thiamine-phosphate diphosphorylase activity
APORC_0445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APORC_0447	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APORC_0448	COG2264	protein methyltransferase activity
APORC_0449	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APORC_0450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APORC_0453	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APORC_0454	COG1648	precorrin-2 dehydrogenase activity
APORC_0454	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APORC_0457	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APORC_0458	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APORC_0461	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APORC_0463	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
APORC_0464	COG0481	GTPase activity
APORC_0466	COG2217	Heavy metal translocating P-type atpase
APORC_0467	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APORC_0472	COG2030	dehydratase
APORC_0475	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APORC_0476	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APORC_0477	COG0542	response to heat
APORC_0485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APORC_0487	COG0772	Belongs to the SEDS family
APORC_0489	COG1968	undecaprenyl-diphosphatase activity
APORC_0490	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
APORC_0492	COG0314	molybdopterin synthase activity
APORC_0494	COG0174	glutamine synthetase
APORC_0499	COG0525	valine-tRNA ligase activity
APORC_0500	COG2814	Major facilitator Superfamily
APORC_0501	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APORC_0505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APORC_0506	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APORC_0507	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APORC_0509	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APORC_0510	COG1136	(ABC) transporter
APORC_0510	COG0577	efflux transmembrane transporter activity
APORC_0511	COG1136	(ABC) transporter
APORC_0511	COG0577	efflux transmembrane transporter activity
APORC_0514	COG0811	peptide transport
APORC_0515	COG0848	biopolymer transport protein
APORC_0516	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
APORC_0518	COG3077	Addiction module antitoxin, RelB DinJ family
APORC_0520	COG0439	Biotin carboxylase
APORC_0521	COG4773	Receptor
APORC_0525	COG0542	response to heat
APORC_0526	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APORC_0527	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APORC_0528	COG0706	membrane insertase activity
APORC_0530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APORC_0532	COG0501	Belongs to the peptidase M48B family
APORC_0534	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APORC_0535	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APORC_0536	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APORC_0538	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APORC_0539	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APORC_0541	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APORC_0542	COG0305	Participates in initiation and elongation during chromosome replication
APORC_0543	COG2165	general secretion pathway protein
APORC_0544	COG4771	TonB-dependent receptor
APORC_0548	COG1966	Carbon starvation protein
APORC_0549	COG0012	GTP binding
APORC_0551	COG3328	transposase activity
APORC_0554	COG3123	guanosine phosphorylase activity
APORC_0555	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APORC_0556	COG0585	pseudouridine synthase activity
APORC_0559	COG0632	four-way junction helicase activity
APORC_0560	COG1181	Belongs to the D-alanine--D-alanine ligase family
APORC_0562	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APORC_0565	COG3201	nicotinamide mononucleotide transporter
APORC_0570	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APORC_0571	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APORC_0571	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APORC_0576	COG3328	transposase activity
APORC_0577	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APORC_0580	COG0730	response to heat
APORC_0581	COG1045	serine acetyltransferase
APORC_0582	COG1166	arginine decarboxylase activity
APORC_0583	COG0124	histidyl-tRNA synthetase
APORC_0584	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APORC_0586	COG0163	prenyltransferase activity
APORC_0588	COG0359	binds to the 23S rRNA
APORC_0589	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APORC_0590	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APORC_0592	COG0084	hydrolase, TatD family'
APORC_0593	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APORC_0594	COG0131	Imidazoleglycerol-phosphate dehydratase
APORC_0595	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APORC_0598	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APORC_0601	COG0051	transcription antitermination factor activity, RNA binding
APORC_0602	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APORC_0603	COG0088	Forms part of the polypeptide exit tunnel
APORC_0604	COG0089	rRNA binding
APORC_0605	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APORC_0606	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APORC_0607	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APORC_0608	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APORC_0609	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APORC_0610	COG0255	Belongs to the universal ribosomal protein uL29 family
APORC_0611	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APORC_0612	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APORC_0613	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APORC_0614	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APORC_0615	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APORC_0616	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APORC_0617	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APORC_0618	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APORC_0619	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APORC_0620	COG0200	Binds to the 23S rRNA
APORC_0621	COG0201	protein transport
APORC_0622	COG0024	Methionine aminopeptidase
APORC_0623	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APORC_0626	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APORC_0628	COG1032	radical SAM domain protein
APORC_0629	COG0563	adenylate kinase activity
APORC_0630	COG0563	adenylate kinase activity
APORC_0634	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APORC_0635	COG0840	transmembrane signaling receptor activity
APORC_0636	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APORC_0637	COG0322	excinuclease ABC activity
APORC_0638	COG0840	transmembrane signaling receptor activity
APORC_0639	COG0753	catalase activity
APORC_0643	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APORC_0645	COG0784	Response regulator, receiver
APORC_0645	COG3437	response regulator, receiver
APORC_0646	COG1338	Plays a role in the flagellum-specific transport system
APORC_0647	COG0768	penicillin binding
APORC_0651	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APORC_0652	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APORC_0654	COG0564	pseudouridine synthase activity
APORC_0655	COG0772	Belongs to the SEDS family
APORC_0658	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
APORC_0660	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APORC_0661	COG3123	guanosine phosphorylase activity
APORC_0665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APORC_0666	COG0066	3-isopropylmalate dehydratase activity
APORC_0667	COG0473	3-isopropylmalate dehydrogenase activity
APORC_0670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APORC_0671	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APORC_0672	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APORC_0673	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APORC_0674	COG0202	RNA polymerase activity
APORC_0675	COG0203	ribosomal protein L17
APORC_0676	COG0154	amidase activity
APORC_0677	COG0516	GMP reductase activity
APORC_0677	COG0517	IMP dehydrogenase activity
APORC_0680	COG0484	heat shock protein binding
APORC_0681	COG0582	viral genome integration into host DNA
APORC_0685	COG1450	Type ii and iii secretion system protein
APORC_0696	COG1472	Belongs to the glycosyl hydrolase 3 family
APORC_0697	COG0640	Transcriptional regulator
APORC_0698	COG2217	Heavy metal translocating P-type atpase
APORC_0699	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APORC_0701	COG1696	Membrane protein involved in D-alanine export
APORC_0703	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APORC_0704	COG0508	dehydrogenase complex catalyzes the overall conversion of
APORC_0705	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APORC_0706	COG0095	Lipoate-protein ligase
APORC_0707	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APORC_0708	COG1944	ATP diphosphatase activity
APORC_0709	COG2258	MOSC domain
APORC_0710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APORC_0711	COG3135	benzoate transporter
APORC_0714	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APORC_0714	COG2169	Transcriptional regulator
APORC_0715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APORC_0721	COG2166	iron-sulfur cluster assembly
APORC_0722	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APORC_0723	COG0719	Fe-S assembly protein
APORC_0724	COG0396	ATPase activity
APORC_0725	COG0719	Fe-S assembly protein
APORC_0728	COG3706	GGDEF domain
APORC_0729	COG0165	Argininosuccinate lyase
APORC_0731	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APORC_0732	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APORC_0734	COG0556	nucleotide-excision repair
APORC_0735	COG3437	response regulator, receiver
APORC_0735	COG0784	Response regulator, receiver
APORC_0736	COG2203	Gaf domain
APORC_0736	COG3706	GGDEF domain
APORC_0736	COG4251	negative regulation of phosphorylation
APORC_0736	COG5001	Diguanylate cyclase
APORC_0737	COG0784	Response regulator, receiver
APORC_0737	COG2198	Histidine kinase
APORC_0737	COG5002	protein histidine kinase activity
APORC_0738	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APORC_0742	COG0698	ribose 5-phosphate isomerase
APORC_0743	COG0681	Belongs to the peptidase S26 family
APORC_0744	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APORC_0745	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
APORC_0746	COG0193	aminoacyl-tRNA hydrolase activity
APORC_0749	COG0860	N-Acetylmuramoyl-L-alanine amidase
APORC_0751	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APORC_0752	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APORC_0753	COG1758	RNA polymerase activity
APORC_0754	COG0528	UMP kinase activity
APORC_0763	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APORC_0766	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
APORC_0770	COG0840	transmembrane signaling receptor activity
APORC_0772	COG0626	cystathionine gamma-synthase activity
APORC_0773	COG1793	dna ligase
APORC_0774	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APORC_0775	COG0133	tryptophan synthase activity
APORC_0777	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APORC_0778	COG0583	DNA-binding transcription factor activity
APORC_0792	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APORC_0793	COG2171	N-acyltransferase activity
APORC_0794	COG0488	(ABC) transporter
APORC_0802	COG3328	transposase activity
APORC_0810	COG1137	ATPase activity
APORC_0812	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APORC_0813	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APORC_0814	COG0137	argininosuccinate synthase activity
APORC_0835	COG1205	dead DEAH box helicase
APORC_0835	COG1111	helicase
APORC_0838	COG0556	nucleotide-excision repair
APORC_0840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APORC_0846	COG0582	viral genome integration into host DNA
APORC_0847	COG2183	response to ionizing radiation
APORC_0849	COG0708	Exodeoxyribonuclease III
APORC_0854	COG0166	Belongs to the GPI family
APORC_0862	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APORC_0866	COG0039	L-malate dehydrogenase activity
APORC_0870	COG4591	ABC-type transport system involved in lipoprotein release permease component
APORC_0871	COG0653	protein targeting
APORC_0872	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
APORC_0875	COG1013	pyruvate-flavodoxin oxidoreductase activity
APORC_0876	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
APORC_0876	COG0674	pyruvate-flavodoxin oxidoreductase activity
APORC_0878	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
APORC_0879	COG0727	PFAM Uncharacterised protein family (UPF0153)
APORC_0881	COG0134	indole-3-glycerol-phosphate synthase activity
APORC_0882	COG0861	Integral membrane protein TerC family
APORC_0883	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APORC_0885	COG0552	protein localization to endoplasmic reticulum
APORC_0886	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APORC_0888	COG1418	mRNA catabolic process
APORC_0889	COG0742	ribosomal rna small subunit methyltransferase
APORC_0890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APORC_0891	COG0300	oxidoreductase activity
APORC_0894	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APORC_0896	COG1611	Belongs to the LOG family
APORC_0898	COG0739	heme binding
APORC_0899	COG0217	transcriptional regulatory protein
APORC_0900	COG1049	propionate catabolic process, 2-methylcitrate cycle
APORC_0901	COG0745	RESPONSE REGULATOR receiver
APORC_0902	COG0784	Response regulator, receiver
APORC_0902	COG4191	Histidine kinase
APORC_0904	COG0113	porphobilinogen synthase activity
APORC_0905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APORC_0906	COG0357	Ribosomal RNA small subunit methyltransferase G
APORC_0915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APORC_0920	COG2244	polysaccharide biosynthetic process
APORC_0922	COG1216	Glycosyl transferase, family 2
APORC_0927	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APORC_0929	COG2337	Toxic component of a toxin-antitoxin (TA) module
APORC_0930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APORC_0933	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APORC_0934	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APORC_0935	COG1328	CTP reductase activity
APORC_0935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APORC_0938	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
APORC_0939	COG2363	Small membrane protein
APORC_0940	COG1666	GTP binding
APORC_0941	COG0494	nUDIX hydrolase
APORC_0943	COG0840	transmembrane signaling receptor activity
APORC_0946	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APORC_0947	COG0247	lactate metabolic process
APORC_0947	COG2181	nitrate reductase activity
APORC_0949	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APORC_0950	COG1663	tetraacyldisaccharide 4'-kinase activity
APORC_0951	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APORC_0952	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
APORC_0956	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APORC_0957	COG0805	protein transport
APORC_0958	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APORC_0964	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APORC_0967	COG0281	malic enzyme
APORC_0967	COG0280	phosphate acetyltransferase
APORC_0968	COG0788	formyltetrahydrofolate deformylase activity
APORC_0969	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APORC_0970	COG1114	Component of the transport system for branched-chain amino acids
APORC_0972	COG1283	sodium-dependent phosphate transmembrane transporter activity
APORC_0974	COG0745	RESPONSE REGULATOR receiver
APORC_0977	COG0330	HflC and HflK could
APORC_0981	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APORC_0983	COG0546	phosphoglycolate phosphatase activity
APORC_0986	COG4206	TonB-dependent receptor
APORC_0987	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APORC_0989	COG4139	cobalamin transport
APORC_0991	COG1160	GTP binding
APORC_0993	COG0151	Belongs to the GarS family
APORC_0997	COG1185	polyribonucleotide nucleotidyltransferase activity
APORC_0998	COG0745	RESPONSE REGULATOR receiver
APORC_0999	COG2198	Histidine kinase
APORC_0999	COG0643	Histidine kinase
APORC_1002	COG2201	protein-glutamate methylesterase activity
APORC_1003	COG2223	nitrite transmembrane transporter activity
APORC_1016	COG0582	viral genome integration into host DNA
APORC_1019	COG0339	signal peptide processing
APORC_1020	COG2890	protein-(glutamine-N5) methyltransferase activity
APORC_1021	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APORC_1022	COG0494	nUDIX hydrolase
APORC_1023	COG0527	aspartate kinase activity
APORC_1026	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APORC_1027	COG0287	Prephenate dehydrogenase
APORC_1028	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APORC_1029	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
APORC_1030	COG0612	Peptidase, M16
APORC_1031	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APORC_1036	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
APORC_1038	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APORC_1038	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APORC_1042	COG0511	ligase activity, forming carbon-carbon bonds
APORC_1043	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
APORC_1050	COG0667	Aldo Keto reductase
APORC_1055	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APORC_1056	COG0484	heat shock protein binding
APORC_1058	COG2833	Protein of unknown function (DUF455)
APORC_1059	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APORC_1060	COG5001	Diguanylate cyclase
APORC_1061	COG0500	methyltransferase
APORC_1062	COG2195	Cleaves the N-terminal amino acid of tripeptides
APORC_1063	COG1333	cytochrome c biogenesis protein
APORC_1063	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APORC_1065	COG2176	DNA-directed DNA polymerase activity
APORC_1066	COG0135	phosphoribosylanthranilate isomerase activity
APORC_1067	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APORC_1068	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
APORC_1069	COG1253	flavin adenine dinucleotide binding
APORC_1070	COG1193	negative regulation of DNA recombination
APORC_1071	COG2249	NAD(P)H dehydrogenase (quinone) activity
APORC_1074	COG1090	epimerase
APORC_1077	COG1119	ATPase activity
APORC_1078	COG0521	Mo-molybdopterin cofactor biosynthetic process
APORC_1080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APORC_1081	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APORC_1083	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APORC_1095	COG1674	ftsk spoiiie
APORC_1095	COG1196	nuclear chromosome segregation
APORC_1096	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APORC_1097	COG0440	acetolactate synthase activity
APORC_1098	COG0028	Belongs to the TPP enzyme family
APORC_1100	COG0248	Ppx GppA phosphatase
APORC_1105	COG0784	Response regulator, receiver
APORC_1105	COG4191	Histidine kinase
APORC_1106	COG4166	transmembrane transport
APORC_1107	COG0745	RESPONSE REGULATOR receiver
APORC_1109	COG0243	molybdopterin cofactor binding
APORC_1111	COG0037	tRNA processing
APORC_1115	COG0501	Belongs to the peptidase M48B family
APORC_1117	COG0824	Thioesterase
APORC_1120	COG0446	pyridine nucleotide-disulphide oxidoreductase
APORC_1121	COG2204	response regulator
APORC_1123	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APORC_1124	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APORC_1126	COG0303	'Molybdopterin
APORC_1128	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APORC_1130	COG0437	4 iron, 4 sulfur cluster binding
APORC_1137	COG2204	response regulator
APORC_1141	COG1305	Transglutaminase-like
APORC_1142	COG0709	Synthesizes selenophosphate from selenide and ATP
APORC_1145	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APORC_1149	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
APORC_1151	COG0436	Aminotransferase
APORC_1152	COG1451	nucleotide metabolic process
APORC_1155	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APORC_1156	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APORC_1156	COG0519	Catalyzes the synthesis of GMP from XMP
APORC_1158	COG2336	PFAM SpoVT AbrB
APORC_1162	COG0596	Alpha beta hydrolase
APORC_1164	COG1132	(ABC) transporter
APORC_1167	COG0328	RNA-DNA hybrid ribonuclease activity
APORC_1168	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APORC_1174	COG3210	domain, Protein
APORC_1175	COG0745	RESPONSE REGULATOR receiver
APORC_1176	COG4191	Histidine kinase
APORC_1177	COG3328	transposase activity
APORC_1179	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APORC_1181	COG0275	rRNA processing
APORC_1183	COG0776	regulation of translation
APORC_1187	COG0739	heme binding
APORC_1189	COG1942	4-Oxalocrotonate Tautomerase
APORC_1198	COG2814	Major facilitator Superfamily
APORC_1200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APORC_1200	COG0301	tRNA thio-modification
APORC_1204	COG1739	Uncharacterized protein family UPF0029
APORC_1206	COG0196	riboflavin kinase activity
APORC_1207	COG2226	methyltransferase
APORC_1208	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APORC_1210	COG0277	FAD linked oxidase domain protein
APORC_1213	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APORC_1215	COG2877	3-deoxy-8-phosphooctulonate synthase activity
APORC_1219	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APORC_1220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APORC_1221	COG0284	orotidine-5'-phosphate decarboxylase activity
APORC_1225	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APORC_1232	COG3645	SOS response
APORC_1239	COG0776	regulation of translation
APORC_1260	COG1215	transferase activity, transferring glycosyl groups
APORC_1266	COG0572	uridine kinase
APORC_1282	COG4974	Belongs to the 'phage' integrase family
APORC_1287	COG1278	Cold shock
APORC_1291	COG0037	tRNA processing
APORC_1305	COG4895	conserved protein (DUF2196)
APORC_1309	COG3328	transposase activity
APORC_1313	COG3736	Type IV secretory pathway, component VirB8
APORC_1315	COG2948	multi-organism process
APORC_1317	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
APORC_1320	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APORC_1323	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APORC_1325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APORC_1327	COG2391	methyltransferase activity
APORC_1328	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APORC_1329	COG0849	cell division
APORC_1331	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APORC_1333	COG1393	Belongs to the ArsC family
APORC_1336	COG0754	glutathionylspermidine amidase activity
APORC_1337	COG1607	acyl-coa hydrolase
APORC_1338	COG0488	(ABC) transporter
APORC_1340	COG0778	Nitroreductase
APORC_1346	COG2855	membrane
APORC_1347	COG0583	DNA-binding transcription factor activity
APORC_1349	COG2249	NAD(P)H dehydrogenase (quinone) activity
APORC_1352	COG2076	Multidrug Resistance protein
APORC_1353	COG2172	sigma factor antagonist activity
APORC_1354	COG0745	RESPONSE REGULATOR receiver
APORC_1356	COG3258	Cytochrome c
APORC_1358	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APORC_1358	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
APORC_1359	COG0484	heat shock protein binding
APORC_1360	COG0789	Transcriptional regulator
APORC_1362	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APORC_1365	COG0728	peptidoglycan biosynthetic process
APORC_1366	COG1132	(ABC) transporter
APORC_1367	COG0167	dihydroorotate dehydrogenase activity
APORC_1368	COG0612	Peptidase, M16
APORC_1369	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APORC_1370	COG1028	Short-chain dehydrogenase reductase Sdr
APORC_1371	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APORC_1372	COG0750	zinc metalloprotease
APORC_1373	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APORC_1374	COG0840	transmembrane signaling receptor activity
APORC_1375	COG0840	transmembrane signaling receptor activity
APORC_1377	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APORC_1381	COG0716	FMN binding
APORC_1384	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
APORC_1386	COG0159	tryptophan synthase activity
APORC_1387	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APORC_1388	COG2255	four-way junction helicase activity
APORC_1389	COG0628	permease
APORC_1399	COG0598	Magnesium transport protein CorA
APORC_1404	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APORC_1405	COG0606	chelatase, subunit chli
APORC_1407	COG0242	peptide deformylase activity
APORC_1408	COG0740	serine-type endopeptidase activity
APORC_1409	COG0544	peptidyl-prolyl cis-trans isomerase activity
APORC_1410	COG2326	polyphosphate kinase activity
APORC_1415	COG0582	viral genome integration into host DNA
APORC_1416	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APORC_1421	COG0732	type I restriction modification DNA specificity domain
APORC_1435	COG0776	regulation of translation
APORC_1445	COG2234	aminopeptidase activity
APORC_1449	COG1401	restriction endodeoxyribonuclease activity
APORC_1486	COG1858	cytochrome C peroxidase
APORC_1492	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APORC_1501	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APORC_1503	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APORC_1506	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APORC_1508	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APORC_1510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APORC_1511	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APORC_1512	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
APORC_1512	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APORC_1513	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APORC_1514	COG1368	sulfuric ester hydrolase activity
APORC_1515	COG0859	PFAM glycosyl transferase family 9
APORC_1517	COG2194	sulfuric ester hydrolase activity
APORC_1518	COG0463	Glycosyl transferase, family 2
APORC_1523	COG3083	sulfuric ester hydrolase activity
APORC_1526	COG0859	PFAM glycosyl transferase family 9
APORC_1528	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APORC_1529	COG0483	inositol monophosphate 1-phosphatase activity
APORC_1538	COG1921	L-seryl-tRNASec selenium transferase activity
APORC_1548	COG3287	FIST C domain
APORC_1548	COG2200	EAL domain
APORC_1548	COG2199	diguanylate cyclase activity
APORC_1549	COG0259	pyridoxamine-phosphate oxidase activity
APORC_1551	COG0513	Belongs to the DEAD box helicase family
APORC_1553	COG0326	Molecular chaperone. Has ATPase activity
APORC_1554	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APORC_1554	COG2755	lipolytic protein G-D-S-L family
APORC_1563	COG4335	DNA alkylation repair
APORC_1564	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APORC_1565	COG0010	Belongs to the arginase family
APORC_1566	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APORC_1567	COG2207	Transcriptional regulator
APORC_1568	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APORC_1569	COG0668	transmembrane transport
APORC_1570	COG1227	inorganic diphosphatase activity
APORC_1571	COG3012	SEC-C Motif Domain Protein
APORC_1575	COG1027	Aspartate ammonia-lyase
APORC_1576	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APORC_1577	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APORC_1578	COG1047	Peptidyl-prolyl cis-trans
APORC_1580	COG2885	chlorophyll binding
APORC_1581	COG0823	Involved in the tonB-independent uptake of proteins
APORC_1583	COG0848	biopolymer transport protein
APORC_1584	COG0811	peptide transport
APORC_1585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APORC_1586	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APORC_1587	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APORC_1588	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APORC_1589	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APORC_1590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APORC_1592	COG1475	DNA binding
APORC_1593	COG1192	Involved in chromosome partitioning
APORC_1594	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
APORC_1594	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
APORC_1596	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APORC_1597	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APORC_1598	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APORC_1599	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APORC_1600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APORC_1601	COG0358	DNA primase activity
APORC_1603	COG0571	ribonuclease III activity
APORC_1604	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APORC_1606	COG2326	polyphosphate kinase activity
APORC_1609	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APORC_1619	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
APORC_1621	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APORC_1622	COG0179	Fumarylacetoacetate (FAA) hydrolase
APORC_1624	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APORC_1625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APORC_1625	COG4191	Histidine kinase
APORC_1627	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APORC_1629	COG1196	nuclear chromosome segregation
APORC_1629	COG0739	heme binding
APORC_1629	COG0741	lytic transglycosylase activity
APORC_1633	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APORC_1634	COG0085	RNA polymerase activity
APORC_1635	COG0222	ribosome binding
APORC_1636	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APORC_1637	COG0081	regulation of translation
APORC_1638	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APORC_1639	COG0250	Participates in transcription elongation, termination and antitermination
APORC_1642	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APORC_1643	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APORC_1649	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APORC_1650	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APORC_1651	COG0444	Belongs to the ABC transporter superfamily
APORC_1652	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APORC_1660	COG3258	Cytochrome c
APORC_1665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APORC_1666	COG0569	domain protein
APORC_1666	COG0475	glutathione-regulated potassium exporter activity
APORC_1667	COG0210	DNA helicase
APORC_1669	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APORC_1670	COG2996	Protein conserved in bacteria
APORC_1671	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APORC_1672	COG1121	(ABC) transporter
APORC_1673	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APORC_1674	COG0840	transmembrane signaling receptor activity
APORC_1675	COG1355	regulation of microtubule-based process
APORC_1677	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APORC_1677	COG1648	precorrin-2 dehydrogenase activity
APORC_1679	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APORC_1680	COG3177	Filamentation induced by cAMP protein fic
APORC_1682	COG0459	protein refolding
APORC_1685	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APORC_1686	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
APORC_1688	COG0835	chemotaxis
APORC_1689	COG1570	exodeoxyribonuclease VII activity
APORC_1690	COG2226	methyltransferase
APORC_1693	COG1692	metallophosphoesterase
APORC_1694	COG5002	protein histidine kinase activity
APORC_1697	COG0840	transmembrane signaling receptor activity
APORC_1698	COG2081	HI0933 family
APORC_1699	COG0642	Histidine kinase
APORC_1700	COG0745	RESPONSE REGULATOR receiver
APORC_1711	COG0546	phosphoglycolate phosphatase activity
APORC_1712	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APORC_1720	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APORC_1725	COG3328	transposase activity
APORC_1728	COG0285	dihydrofolate synthase activity
APORC_1730	COG0495	leucyl-tRNA aminoacylation
APORC_1732	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
APORC_1733	COG1360	Flagellar Motor Protein
APORC_1735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APORC_1736	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APORC_1737	COG1862	Preprotein translocase
APORC_1738	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APORC_1739	COG4771	TonB-dependent receptor
APORC_1740	COG0617	tRNA 3'-terminal CCA addition
APORC_1741	COG0668	transmembrane transport
APORC_1742	COG0442	prolyl-tRNA aminoacylation
APORC_1743	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
APORC_1744	COG0142	geranyltranstransferase activity
APORC_1746	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APORC_1747	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APORC_1749	COG0811	peptide transport
APORC_1750	COG0848	biopolymer transport protein
APORC_1751	COG0628	permease
APORC_1752	COG0191	fructose-bisphosphate aldolase activity
APORC_1753	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APORC_1754	COG0745	RESPONSE REGULATOR receiver
APORC_1755	COG0642	Histidine kinase
APORC_1757	COG2404	hydrolase activity, acting on ester bonds
APORC_1758	COG1959	2 iron, 2 sulfur cluster binding
APORC_1759	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APORC_1760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APORC_1764	COG0243	molybdopterin cofactor binding
APORC_1765	COG0437	4 iron, 4 sulfur cluster binding
APORC_1766	COG0348	domain, Protein
APORC_1767	COG3043	anaerobic respiration
APORC_1771	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APORC_1779	COG1971	Probably functions as a manganese efflux pump
APORC_1780	COG3766	membrane
APORC_1781	COG0180	Tryptophanyl-tRNA synthetase
APORC_1782	COG0745	RESPONSE REGULATOR receiver
APORC_1783	COG2205	protein histidine kinase activity
APORC_1784	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APORC_1786	COG2824	Alkylphosphonate utilization operon protein PhnA
APORC_1788	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APORC_1789	COG0540	Belongs to the ATCase OTCase family
APORC_1791	COG1335	isochorismatase
APORC_1792	COG0181	hydroxymethylbilane synthase activity
APORC_1794	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APORC_1795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APORC_1796	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APORC_1797	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APORC_1798	COG0450	alkyl hydroperoxide reductase
APORC_1800	COG0105	UTP biosynthetic process
APORC_1802	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APORC_1803	COG0416	fatty acid biosynthetic process
APORC_1804	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APORC_1808	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APORC_1809	COG1053	succinate dehydrogenase
APORC_1811	COG1007	ATP synthesis coupled electron transport
APORC_1813	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APORC_1814	COG0713	ATP synthesis coupled electron transport
APORC_1815	COG0839	Belongs to the complex I subunit 6 family
APORC_1816	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APORC_1817	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APORC_1818	COG1034	ATP synthesis coupled electron transport
APORC_1819	COG0372	Belongs to the citrate synthase family
APORC_1821	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
APORC_1822	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APORC_1822	COG0649	NAD binding
APORC_1823	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APORC_1824	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APORC_1825	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
APORC_1826	COG3610	response to peptide
APORC_1827	COG2966	Psort location CytoplasmicMembrane, score
APORC_1829	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APORC_1830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APORC_1832	COG0840	transmembrane signaling receptor activity
APORC_1833	COG3706	GGDEF domain
APORC_1837	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APORC_1839	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
APORC_1841	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APORC_1842	COG2828	Protein conserved in bacteria
APORC_1843	COG0741	lytic transglycosylase activity
APORC_1844	COG0469	pyruvate kinase activity
APORC_1846	COG0792	nuclease activity
APORC_1847	COG0156	8-amino-7-oxononanoate synthase activity
APORC_1848	COG0288	reversible hydration of carbon dioxide
APORC_1850	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
APORC_1852	COG2121	Domain of unknown function (DUF374)
APORC_1853	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APORC_1855	COG0195	Participates in both transcription termination and antitermination
APORC_1856	COG0215	cysteine-tRNA ligase activity
APORC_1858	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APORC_1863	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APORC_1870	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APORC_1878	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APORC_1882	COG0582	viral genome integration into host DNA
APORC_1883	COG0629	single-stranded DNA binding
APORC_1884	COG0360	Binds together with S18 to 16S ribosomal RNA
APORC_1886	COG0557	exoribonuclease II activity
APORC_1887	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APORC_1890	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APORC_1891	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APORC_1892	COG0492	ferredoxin-NADP+ reductase activity
APORC_1893	COG3118	belongs to the thioredoxin family
APORC_1894	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APORC_1897	COG5002	protein histidine kinase activity
APORC_1898	COG0745	RESPONSE REGULATOR receiver
APORC_1899	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APORC_1900	COG0129	dihydroxy-acid dehydratase activity
APORC_1904	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APORC_1905	COG0585	pseudouridine synthase activity
APORC_1908	COG0793	Belongs to the peptidase S41A family
APORC_1910	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APORC_1911	COG0047	phosphoribosylformylglycinamidine synthase activity
APORC_1913	COG0204	Acyl-transferase
APORC_1914	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APORC_1915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APORC_1916	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APORC_1917	COG0018	arginyl-trna synthetase
APORC_1919	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APORC_1921	COG0126	phosphoglycerate kinase activity
APORC_1922	COG0149	triose-phosphate isomerase activity
APORC_1923	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APORC_1924	COG0019	diaminopimelate decarboxylase activity
APORC_1925	COG1605	Chorismate mutase
APORC_1925	COG0077	Prephenate dehydratase
APORC_1926	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APORC_1927	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APORC_1929	COG0424	maF-like protein
APORC_1931	COG2095	MarC family integral membrane protein
APORC_1933	COG0471	metal ion transport
APORC_1935	COG4232	protein-disulfide reductase activity
APORC_1937	COG0189	ligase activity
APORC_1940	COG3287	FIST C domain
APORC_1940	COG2199	diguanylate cyclase activity
APORC_1940	COG2200	EAL domain
APORC_1944	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
APORC_1945	COG0443	Heat shock 70 kDa protein
APORC_1946	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APORC_1947	COG1420	regulation of RNA biosynthetic process
APORC_1951	COG0310	cobalt ion transport
APORC_1953	COG0375	protein maturation
APORC_1954	COG0309	Hydrogenase expression formation protein (HypE)
APORC_1958	COG0298	carbon dioxide binding
APORC_1959	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APORC_1961	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APORC_1962	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APORC_1963	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
APORC_1964	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
APORC_1965	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
APORC_1966	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
APORC_1967	COG0101	tRNA pseudouridine synthase activity
APORC_1970	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APORC_1971	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APORC_1972	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APORC_1974	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APORC_1975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APORC_1977	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APORC_1981	COG2089	acid synthase
APORC_1982	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APORC_1984	COG1083	cytidylyl-transferase
APORC_1985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APORC_1986	COG1086	Polysaccharide biosynthesis protein
APORC_1988	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APORC_1989	COG0733	neurotransmitter:sodium symporter activity
APORC_1990	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
APORC_1992	COG0659	secondary active sulfate transmembrane transporter activity
APORC_1994	COG1222	aaa ATPase
APORC_1996	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
APORC_1997	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APORC_2001	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APORC_2002	COG0148	phosphopyruvate hydratase activity
APORC_2005	COG0445	tRNA wobble uridine modification
APORC_2007	COG2239	Acts as a magnesium transporter
APORC_2010	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APORC_2011	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APORC_2012	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APORC_2013	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APORC_2014	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APORC_2021	COG0670	Belongs to the BI1 family
APORC_2023	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APORC_2024	COG0233	cytoplasmic translational termination
APORC_2025	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APORC_2031	COG3022	response to hydroperoxide
APORC_2032	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
APORC_2037	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APORC_2040	COG0546	phosphoglycolate phosphatase activity
APORC_2041	COG0243	molybdopterin cofactor binding
APORC_2043	COG0783	Belongs to the Dps family
APORC_2044	COG2814	Major facilitator Superfamily
APORC_2046	COG3706	GGDEF domain
APORC_2048	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APORC_2050	COG0840	transmembrane signaling receptor activity
APORC_2051	COG2081	HI0933 family
APORC_2053	COG1959	2 iron, 2 sulfur cluster binding
APORC_2056	COG0175	sulfate reduction
APORC_2057	COG0175	sulfate reduction
APORC_2058	COG2895	sulfate adenylyltransferase (ATP) activity
APORC_2060	COG0133	tryptophan synthase activity
APORC_2062	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APORC_2064	COG1408	metallophosphoesterase
APORC_2065	COG1999	signal sequence binding
APORC_2068	COG2200	EAL domain
APORC_2068	COG3287	FIST C domain
APORC_2068	COG2199	diguanylate cyclase activity
APORC_2071	COG2391	methyltransferase activity
APORC_2072	COG0425	Belongs to the sulfur carrier protein TusA family
APORC_2075	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
APORC_2076	COG2860	membrane
APORC_2081	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group