locus-tag	class	description
EI285_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
EI285_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
EI285_00015	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EI285_00020	ENOG4105CAY	ferredoxin--nadp reductase
EI285_00025	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
EI285_00050	ENOG4108BSC	Methyltransferase
EI285_00055	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EI285_00060	ENOG4105E0C	molybdate abc transporter
EI285_00070	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
EI285_00075	ENOG4105F4R	Transcriptional regulator mode
EI285_00095	ENOG4105EI2	Pseudouridine synthase
EI285_00100	ENOG4107QTF	adenylosuccinate lyase
EI285_00105	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
EI285_00110	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
EI285_00120	ENOG4105CE9	30S ribosomal protein S2
EI285_00130	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
EI285_00135	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
EI285_00145	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
EI285_00150	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
EI285_00155	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
EI285_00160	ENOG4105C1J	atp-dependent rna helicase
EI285_00165	ENOG4105CJ3	phosphate transporter
EI285_00175	ENOG4105CAQ	asparagine synthetase
EI285_00185	ENOG4108IAB	Phoh family
EI285_00190	ENOG4108YXA	Membrane
EI285_00195	ENOG4105D1H	recombination factor protein RarA
EI285_00200	ENOG4105FE9	pseudouridine synthase
EI285_00205	ENOG4105C2X	Arabinose 5-phosphate isomerase
EI285_00210	ENOG4105CN5	Metallo-Beta-Lactamase
EI285_00215	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
EI285_00220	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
EI285_00235	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
EI285_00240	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
EI285_00255	ENOG4105D6E	homoserine dehydrogenase
EI285_00260	ENOG4105CHM	Aminotransferase
EI285_00270	ENOG4105C2N	RNA methyltransferase TrmH family group 3
EI285_00280	ENOG41082DI	50s ribosomal protein l31
EI285_00285	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
EI285_00295	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
EI285_00315	ENOG4105PWN	phosphate abc transporter
EI285_00320	ENOG4108M8H	domain protein
EI285_00325	ENOG4105C8U	phosphate abc transporter
EI285_00330	ENOG4105E2Z	phosphate ABC transporter (Permease
EI285_00335	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
EI285_00350	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EI285_00355	ENOG4105F3H	Histidine kinase
EI285_00360	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
EI285_00365	ENOG4108UJD	30S ribosomal protein S9
EI285_00370	ENOG4105ETU	transcriptional activator (TenA
EI285_00380	ENOG4105D41	biosynthesis protein thiH
EI285_00395	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
EI285_00400	ENOG41084QV	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
EI285_00405	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
EI285_00410	ENOG4105DWF	phosphomethylpyrimidine kinase
EI285_00435	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
EI285_00440	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
EI285_00465	ENOG4105CM2	brancheD-chain amino acid aminotransferase
EI285_00480	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
EI285_00495	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
EI285_00500	ENOG4108JPW	Aminotransferase
EI285_00505	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
EI285_00520	ENOG4105D1F	ATP-binding protein
EI285_00530	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
EI285_00540	ENOG4108ZAI	phosphatidylglycerophosphatase a
EI285_00550	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
EI285_00560	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
EI285_00565	ENOG4105CYE	ATP phosphoribosyltransferase regulatory subunit
EI285_00570	ENOG4107UUH	Aminotransferase
EI285_00590	ENOG4105C2I	pirin domain protein
EI285_00600	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
EI285_00605	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
EI285_00610	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
EI285_00620	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
EI285_00625	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
EI285_00640	ENOG4108Z0Z	intracellular protease Pfpi family
EI285_00645	ENOG4105C0B	DNA polymerase III (alpha subunit)
EI285_00650	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
EI285_00665	ENOG4105QNF	Outer membrane lipoprotein
EI285_00695	ENOG4105BZU	Histidine kinase
EI285_00700	ENOG4105DY9	regulatoR
EI285_00705	ENOG4108HRK	Histidine kinase
EI285_00710	ENOG4105EWK	phytoene
EI285_00715	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
EI285_00730	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
EI285_00740	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
EI285_00745	ENOG4108317	Binds directly to 16S ribosomal RNA (By similarity)
EI285_00750	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
EI285_00755	ENOG410813J	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
EI285_00760	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
EI285_00765	ENOG41080AZ	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
EI285_00780	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
EI285_00785	ENOG41084M8	50s ribosomal protein L35
EI285_00790	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
EI285_00795	ENOG4105C22	threonyL-tRNA synthetase
EI285_00815	ENOG4105KNE	Phosphatidate cytidylyltransferase
EI285_00820	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
EI285_00835	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
EI285_00845	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
EI285_00905	ENOG4105C8Q	Methyl-accepting chemotaxis
EI285_00910	ENOG4105BZU	Histidine kinase
EI285_00915	ENOG4105CV1	Transketolase (EC 2.2.1.1)
EI285_00920	ENOG4108UXE	Protein tyrosine phosphatase
EI285_00940	ENOG4105KK4	UPF0060 membrane protein
EI285_00975	ENOG4108YZA	Nitrogen regulatory protein pii
EI285_00985	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
EI285_00990	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
EI285_01000	ENOG4105VS8	Flagellar biosynthetic protein fliq
EI285_01025	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
EI285_01055	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
EI285_01065	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
EI285_01075	ENOG410829W	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
EI285_01090	ENOG4105D6U	Sodium Glutamate Symporter
EI285_01095	ENOG4105GSH	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
EI285_01105	ENOG4105EAC	phosphoserine phosphatase
EI285_01110	ENOG4107V25	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
EI285_01115	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
EI285_01120	ENOG4105DRB	nucleoside-specific channel-forming protein
EI285_01125	ENOG4105KUZ	arsenate reductase
EI285_01130	ENOG410855J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
EI285_01135	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
EI285_01145	ENOG4105DFU	Cell wall formation (By similarity)
EI285_01150	ENOG4106K80	
EI285_01160	ENOG4105DUM	transcriptional regulator, lysR family
EI285_01170	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
EI285_01175	ENOG4107Z7S	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
EI285_01180	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
EI285_01185	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
EI285_01240	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
EI285_01255	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
EI285_01265	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
EI285_01280	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
EI285_01290	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
EI285_01300	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
EI285_01305	ENOG4105MGB	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
EI285_01310	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
EI285_01315	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
EI285_01320	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
EI285_01325	ENOG4108JQ1	Dehydrogenase
EI285_01330	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
EI285_01335	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
EI285_01340	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
EI285_01345	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
EI285_01350	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
EI285_01365	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
EI285_01370	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
EI285_01375	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
EI285_01380	ENOG4105CHR	reductase
EI285_01385	ENOG4107XWN	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
EI285_01395	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
EI285_01405	ENOG4107YV6	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
EI285_01420	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
EI285_01425	ENOG4105DQV	Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity)
EI285_01430	ENOG4107QID	Threonine synthase
EI285_01435	ENOG4105CAS	nag kinase
EI285_01440	ENOG4105ENA	helicase
EI285_01445	ENOG4107WJT	it plays a direct role in the translocation of protons across the membrane (By similarity)
EI285_01450	ENOG4105C7B	Threonine dehydratase
EI285_01455	ENOG4107QYE	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
EI285_01465	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
EI285_01470	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
EI285_01475	ENOG4107T5V	SNARE associated Golgi
EI285_01480	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
EI285_01535	ENOG4105CXT	aspartate transcarbamylase
EI285_01550	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
EI285_01560	ENOG4105C8Y	Acetylornithine aminotransferase
EI285_01565	ENOG4105JJR	Histidine kinase
EI285_01570	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EI285_01575	ENOG4105DSF	transport protein
EI285_01585	ENOG4105C31	Tryptophanyl-tRNA synthetase
EI285_01590	ENOG4105CHH	sulfate transporter
EI285_01605	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
EI285_01625	ENOG4108ZMS	Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity)
EI285_01630	ENOG4105GXZ	Ferredoxin-type protein NapH
EI285_01635	ENOG4108BGM	Quinol dehydrogenase periplasmic component
EI285_01640	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
EI285_01655	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
EI285_01660	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
EI285_01670	ENOG4108KA0	Inherit from COG: Phosphoesterase, DHHA1
EI285_01680	ENOG4105ECM	Sensor protein basS pmrB
EI285_01685	ENOG4105ETX	regulatoR
EI285_01690	ENOG4105EIN	peptidylprolyl cis-trans isomerase
EI285_01695	ENOG4105D2N	Aldolase
EI285_01700	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
EI285_01710	ENOG4105SG9	biopolymer transport protein, ExbD
EI285_01730	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
EI285_01740	ENOG4105EAH	synthase
EI285_01745	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
EI285_01750	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
EI285_01760	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
EI285_01785	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
EI285_01790	ENOG4105VIE	preprotein translocase, subunit YajC
EI285_01795	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
EI285_01800	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
EI285_01815	ENOG4108SEK	ompa motb domain protein
EI285_01830	ENOG4105C8T	Leucyl-tRNA synthetase
EI285_01840	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
EI285_01870	ENOG4108JA2	transcriptioN-repair coupling factor
EI285_01905	ENOG4105CBX	hi0933 family
EI285_01910	ENOG4105C8Q	Methyl-accepting chemotaxis
EI285_01925	ENOG4105GR3	Histidine kinase
EI285_01930	ENOG4105D48	metallophosphoesterase
EI285_01950	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
EI285_01955	ENOG4108V3W	Chemotaxis protein, CheW
EI285_01960	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
EI285_01965	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
EI285_01970	ENOG41084FT	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
EI285_01980	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
EI285_01985	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
EI285_01995	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EI285_02000	ENOG4105GR3	Histidine kinase
EI285_02005	ENOG4105ECY	inositol monophosphatase
EI285_02010	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
EI285_02020	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
EI285_02025	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
EI285_02035	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
EI285_02045	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
EI285_02050	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
EI285_02055	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
EI285_02060	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
EI285_02075	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
EI285_02085	ENOG41081FY	multiple antibiotic resistance (MarC)-related
EI285_02095	ENOG4105BZU	Histidine kinase
EI285_02105	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
EI285_02115	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
EI285_02120	ENOG4105NBF	ammecr1 domain protein
EI285_02125	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
EI285_02130	ENOG4105C8Q	Methyl-accepting chemotaxis
EI285_02135	ENOG4107S90	membrAne
EI285_02140	ENOG4105FDK	ABC transporter
EI285_02150	ENOG4105QNR	S1 RNA binding domain protein
EI285_02155	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
EI285_02165	ENOG4105ENA	helicase
EI285_02175	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
EI285_02200	ENOG41088H4	Diheme cytochrome SoxA (Sulfur oxidation)
EI285_02235	ENOG4108JQC	penicillin-binding protein 1A
EI285_02240	ENOG4108JQ7	(ABC) transporter
EI285_02245	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
EI285_02250	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
EI285_02280	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
EI285_02285	ENOG41086AR	50S ribosomal protein L33
EI285_02300	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
EI285_02305	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
EI285_02310	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
EI285_02315	ENOG4108VZM	50s ribosomal protein L10
EI285_02320	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
EI285_02325	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
EI285_02330	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
EI285_02345	ENOG4105BZU	Histidine kinase
EI285_02350	ENOG4105E4C	Lytic transglycosylase catalytic
EI285_02360	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
EI285_02365	ENOG4105DC1	bifunctional purine biosynthesis protein purh
EI285_02370	ENOG4105BZU	Histidine kinase
EI285_02375	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
EI285_02390	ENOG4105E0X	reductase
EI285_02400	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
EI285_02415	ENOG4105CSR	polyphosphate kinase 2
EI285_02420	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
EI285_02425	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
EI285_02435	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
EI285_02440	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
EI285_02445	ENOG4105K46	50S ribosomal protein l27
EI285_02450	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EI285_02455	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
EI285_02460	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
EI285_02470	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
EI285_02475	ENOG4107QJE	Chromosome Partitioning Protein
EI285_02480	ENOG4105FA0	parb-like partition protein
EI285_02490	ENOG4105YF2	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
EI285_02495	ENOG4105PQH	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
EI285_02500	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
EI285_02505	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
EI285_02510	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
EI285_02515	ENOG41082MC	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
EI285_02520	ENOG4105E02	MotA TolQ exbB proton channel
EI285_02525	ENOG4105M8F	Biopolymer transport protein exbD tolR
EI285_02535	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
EI285_02540	ENOG4105CDV	Ompa motb domain protein
EI285_02550	ENOG4108YZY	peptidylprolyl cis-trans isomerase
EI285_02555	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
EI285_02560	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
EI285_02565	ENOG4108IJ0	Aspartate ammonia-lyase
EI285_02575	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
EI285_02580	ENOG4105CUY	Mechanosensitive ion channel
EI285_02585	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
EI285_02595	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
EI285_02605	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
EI285_02610	ENOG4105VEQ	Cold shock protein
EI285_02615	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
EI285_02625	ENOG4105F1N	DNA alkylation repair
EI285_02645	ENOG4105CH6	catalase
EI285_02650	ENOG4105JXB	ankyrin repeat-containing protein
EI285_02670	ENOG4107VQW	regulatoR
EI285_02675	ENOG4105BZU	Histidine kinase
EI285_02680	ENOG4105C58	cytochrome c oxidase accessory protein ccog
EI285_02685	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
EI285_02695	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
EI285_02700	ENOG4105C8Q	Methyl-accepting chemotaxis
EI285_02705	ENOG4105DFA	alanine racemase domain protein
EI285_02710	ENOG4105DZP	Membrane-associated zinc metalloprotease
EI285_02715	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
EI285_02720	ENOG4105CAN	Short-chain dehydrogenase reductase Sdr
EI285_02725	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
EI285_02735	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
EI285_02740	ENOG4105BZ1	(ABC) transporter
EI285_02745	ENOG4105CJR	Integral membrane protein (MviN
EI285_02760	ENOG41080V7	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
EI285_02770	ENOG4105KNI	merR family transcriptional Regulator
EI285_02775	ENOG4105DVC	DnaJ domain protein
EI285_02780	ENOG4105H3G	oxidoreductase
EI285_02795	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
EI285_02805	ENOG4105C1J	atp-dependent rna helicase
EI285_02810	ENOG4105BZU	Histidine kinase
EI285_02815	ENOG41076HS	cation diffusion facilitator family transporter
EI285_02820	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
EI285_02825	ENOG4105BZU	Histidine kinase
EI285_02865	ENOG4107X59	exodeoxyribonuclease V beta
EI285_02885	ENOG4108T3F	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
EI285_02890	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
EI285_02895	ENOG4105C2M	dna polymerase I
EI285_02910	ENOG4105ECP	epimerase
EI285_02915	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
EI285_02920	ENOG4105E0X	reductase
EI285_02955	ENOG4105D7W	serine acetyltransferase
EI285_02960	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
EI285_02965	ENOG4105CUT	histidyl-tRNA synthetase
EI285_02970	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
EI285_02985	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
EI285_02990	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
EI285_03000	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
EI285_03005	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
EI285_03010	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
EI285_03020	ENOG4105F8V	Hydrolase, tatD family
EI285_03025	ENOG4105K6T	rare lipoprotein A
EI285_03030	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
EI285_03035	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
EI285_03050	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
EI285_03055	ENOG4105KY5	gCN5-related N-acetyltransferase
EI285_03060	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
EI285_03065	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
EI285_03070	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
EI285_03075	ENOG4105KZZ	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
EI285_03080	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EI285_03085	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
EI285_03090	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
EI285_03095	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
EI285_03100	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
EI285_03105	ENOG41084HJ	50s ribosomal protein l29
EI285_03110	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
EI285_03115	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
EI285_03120	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
EI285_03130	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
EI285_03135	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
EI285_03140	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
EI285_03145	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
EI285_03150	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
EI285_03155	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
EI285_03160	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
EI285_03165	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
EI285_03170	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
EI285_03175	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
EI285_03185	ENOG4105C9M	aspartyl-trna synthetase
EI285_03190	ENOG4105CCT	upf0313 protein
EI285_03195	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
EI285_03200	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
EI285_03215	ENOG4105C87	Aminotransferase class I and II
EI285_03220	ENOG4105C8Q	Methyl-accepting chemotaxis
EI285_03225	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
EI285_03230	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
EI285_03235	ENOG4105BZS	acriflavin resistance protein
EI285_03245	ENOG410624X	efflux transporter, rnd family, mfp subunit
EI285_03255	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
EI285_03260	ENOG4105CN7	Flagellar biosynthetic protein FliP
EI285_03265	ENOG4105CJN	penicillin-binding protein
EI285_03285	ENOG4105CAK	Cell division ATP-binding protein ftsE
EI285_03290	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
EI285_03300	ENOG4105C34	Pseudouridine synthase
EI285_03305	ENOG4105CNI	cell division protein FtsW
EI285_03315	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
EI285_03320	ENOG4105NBK	UPF0345 protein
EI285_03335	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
EI285_03340	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
EI285_03345	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
EI285_03360	ENOG41067V7	50S ribosomal protein L36
EI285_03365	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EI285_03370	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
EI285_03375	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
EI285_03380	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
EI285_03385	ENOG4108ZT0	50S ribosomal protein l17
EI285_03390	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
EI285_03395	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
EI285_03400	ENOG4105CGY	Dna recombination protein
EI285_03410	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
EI285_03415	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
EI285_03420	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
EI285_03425	ENOG4105C1J	atp-dependent rna helicase
EI285_03430	ENOG4105C59	p-type ATPase
EI285_03440	ENOG4107QN2	dihydrolipoyl dehydrogenase
EI285_03445	ENOG4107QSN	dihydrolipoamide acetyltransferase
EI285_03450	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
EI285_03455	ENOG4105DF9	Lipoate-protein, ligase
EI285_03460	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
EI285_03465	ENOG4105DF3	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity)
EI285_03470	ENOG4105C8Q	Methyl-accepting chemotaxis
EI285_03475	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
EI285_03480	ENOG4105DDY	UPF0142 protein ycaO
EI285_03490	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
EI285_03495	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
EI285_03510	ENOG4108JU6	CBS domain protein
EI285_03515	ENOG4105DSF	transport protein
EI285_03535	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
EI285_03575	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
EI285_03615	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
EI285_03630	ENOG410841J	DNA-binding protein Hu
EI285_03785	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
EI285_03805	ENOG4107VAM	peptidase, m28
EI285_03825	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
EI285_03845	ENOG4107VAM	peptidase, m28
EI285_03865	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
EI285_03910	ENOG4105CB5	ATP-dependent DNA helicase recG
EI285_03915	ENOG4105DZR	Type I site-specific deoxyribonuclease
EI285_03960	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
EI285_03965	ENOG4105M7K	Involved in the transcription termination process (By similarity)
EI285_03970	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
EI285_03975	ENOG4105E9M	CRISPR-associated protein, Csn1 family
EI285_03995	ENOG4105WKZ	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
EI285_04000	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
EI285_04010	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
EI285_04020	ENOG4107S2Z	UPF0761 membrane protein
EI285_04025	ENOG4105CQB	FAD linked oxidase domain protein
EI285_04035	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EI285_04040	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
EI285_04050	ENOG4105DX0	Hemolysin A
EI285_04060	ENOG4106K80	
EI285_04065	ENOG4106K80	
EI285_04095	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
EI285_04115	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
EI285_04125	ENOG4105VCH	membrane
EI285_04150	ENOG4105CBX	hi0933 family
EI285_04180	ENOG4105C25	Primosomal protein n'
EI285_04185	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
EI285_04190	ENOG4105C5H	ABC transporter
EI285_04220	ENOG4107QHF	type ii secretion system protein e
EI285_04265	ENOG4108IUZ	ABC transporter
EI285_04275	ENOG4107QYG	anthranilate phosphoribosyltransferase
EI285_04280	ENOG410854I	s4 domain protein
EI285_04285	ENOG4105CDH	Citrulline--aspartate ligase
EI285_04290	ENOG4108Z0R	Transferase
EI285_04300	ENOG4105C94	Transporter
EI285_04305	ENOG4108ISG	Major Facilitator
EI285_04310	ENOG410841J	DNA-binding protein Hu
EI285_04315	ENOG4105CGK	Exodeoxyribonuclease III
EI285_04335	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
EI285_04340	ENOG4108RA0	tripartite ATP-independent periplasmic transporter, DctQ component
EI285_04345	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
EI285_04350	ENOG4105CQZ	Histidine kinase
EI285_04355	ENOG410812K	response regulator receiver protein
EI285_04365	ENOG4107QP8	phosphohexose isomerase
EI285_04370	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
EI285_04405	ENOG41084IH	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
EI285_04445	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
EI285_04450	ENOG4105EM7	Selenocysteine-specific translation elongation factor
EI285_04455	ENOG4105C1Y	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity)
EI285_04480	ENOG4105D3R	alkyl hydroperoxide reductase
EI285_04485	ENOG4105C8Q	Methyl-accepting chemotaxis
EI285_04490	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
EI285_04495	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
EI285_04500	ENOG4108KS2	transglutaminase domain protein
EI285_04515	ENOG4105K3M	)-transporter
EI285_04520	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EI285_04560	ENOG4105QAX	Iron-sulfur
EI285_04570	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
EI285_04590	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
EI285_04595	ENOG4105C8W	ABC transporter
EI285_04600	ENOG4107A5B	Binding-protein-dependent transport systems, inner membrane component
EI285_04615	ENOG4107S7U	Sulfide dehydrogenase
EI285_04625	ENOG4105BZU	Histidine kinase
EI285_04630	ENOG4105BZ1	(ABC) transporter
EI285_04640	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
EI285_04675	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
EI285_04680	ENOG4108IYU	L-aspartate oxidase
EI285_04695	ENOG4105CHM	Aminotransferase
EI285_04715	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
EI285_04740	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
EI285_04745	ENOG4108URH	decarboxylase
EI285_04765	ENOG4105CDY	transcriptional regulatory protein
EI285_04785	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
EI285_04790	ENOG4107QIJ	Aconitate hydratase 2
EI285_04795	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
EI285_04840	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
EI285_04845	ENOG4107QSA	Oxaloacetate decarboxylase
EI285_04865	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
EI285_04875	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EI285_04900	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
EI285_04910	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
EI285_04915	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EI285_04925	ENOG4108V06	Glutathione peroxidase
EI285_04955	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
EI285_04965	ENOG4105EEI	dihydropteroate synthase
EI285_04980	ENOG4105CFH	Aspartokinase
EI285_04985	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
EI285_04990	ENOG4105CSA	Coproporphyrinogen iii oxidase
EI285_04995	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
EI285_05000	ENOG4105DGW	oligopeptidase A
EI285_05015	ENOG4108EU4	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
EI285_05020	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
EI285_05030	ENOG4105BZU	Histidine kinase
EI285_05035	ENOG4105CBS	Chea signal transduction histidine kinase
EI285_05040	ENOG4108VYJ	response regulator receiver protein
EI285_05045	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
EI285_05055	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
EI285_05065	ENOG4105C12	Phosphoribosylglycinamide synthetase
EI285_05075	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
EI285_05080	ENOG4105MS2	ribosomal subunit Interface protein
EI285_05085	ENOG4105CHR	reductase
EI285_05090	ENOG4105CNU	cell division protein FtsK
EI285_05095	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
EI285_05100	ENOG4108ZP8	Acetolactate synthase small subunit
EI285_05105	ENOG4105C7K	acetolactate synthase
EI285_05115	ENOG4105C9X	ppx gppa phosphatase
EI285_05120	ENOG4105VE1	Phosphatidylcholine synthase
EI285_05140	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
EI285_05150	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
EI285_05160	ENOG4105C2Y	STE24 endopeptidase EC 3.4.24.84
EI285_05170	ENOG4107YD3	Thioesterase
EI285_05180	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
EI285_05185	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
EI285_05205	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
EI285_05210	ENOG41084AD	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
EI285_05215	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
EI285_05220	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
EI285_05255	ENOG4105BZU	Histidine kinase
EI285_05265	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
EI285_05280	ENOG4105C8Q	Methyl-accepting chemotaxis
EI285_05300	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
EI285_05310	ENOG4105D52	delta-aminolevulinic acid dehydratase
EI285_05315	ENOG4105BZU	Histidine kinase
EI285_05325	ENOG4105C5E	polysaccharide biosynthesis protein
EI285_05330	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
EI285_05335	ENOG4105ESV	Glycosyl transferase, family 4
EI285_05340	ENOG4105UG9	Antitoxin of the YafO-YafN toxin-antitoxin system
EI285_05350	ENOG4108RT7	Glycosyl transferase, family 2
EI285_05385	ENOG4105EWK	phytoene
EI285_05390	ENOG4105C30	Nad-dependent epimerase dehydratase
EI285_05400	ENOG4105FGF	GDP-mannose mannosyl hydrolase
EI285_05415	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
EI285_05430	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
EI285_05435	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
EI285_05460	ENOG4105CPC	Aldo Keto reductase
EI285_05485	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
EI285_05490	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
EI285_05500	ENOG4105D65	subunit l
EI285_05505	ENOG4108ZE9	Monovalent cation H antiporter subunit C
EI285_05510	ENOG4107R4Z	monovalent cation h antiporter subunit d
EI285_05515	ENOG4105SC1	monovalent cation H antiporter subunit E
EI285_05520	ENOG4105W4C	monovalent cation H antiporter subunit F
EI285_05525	ENOG4105KJM	monovalent cation h antiporter subunit g
EI285_05535	ENOG4105C5X	domain protein
EI285_05545	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
EI285_05550	ENOG4105CIN	aminoacyl-histidine dipeptidase
EI285_05555	ENOG4105CRE	cytochrome C
EI285_05565	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
EI285_05570	ENOG4105DJV	ribulose-phosphate 3-epimerase
EI285_05575	ENOG4105HDD	phospholipase
EI285_05585	ENOG4107VIJ	nudix hydrolase
EI285_05590	ENOG4108VPT	UPF0234 protein
EI285_05600	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
EI285_05605	ENOG4105DBV	ornithine carbamoyltransferase
EI285_05610	ENOG4105D4P	Coproporphyrinogen iii oxidase
EI285_05625	ENOG4105DKW	ABC transporter
EI285_05635	ENOG4105C37	(CBS) domain
EI285_05640	ENOG4105C98	muts2 protein
EI285_05645	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
EI285_05655	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
EI285_05660	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
EI285_05670	ENOG4105D49	3-dehydroquinate synthase
EI285_05680	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
EI285_05685	ENOG4108JJB	ABC transporter
EI285_05690	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
EI285_05695	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
EI285_05710	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
EI285_05715	ENOG4105I08	Pseudouridine synthase
EI285_05720	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
EI285_05740	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
EI285_05745	ENOG4105C5H	ABC transporter
EI285_05755	ENOG4105DR5	peptidase
EI285_05765	ENOG4105DK0	Indole-3-glycerol phosphate synthase
EI285_05775	ENOG4105QTX	Pfam:UPF0153
EI285_05780	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
EI285_05790	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
EI285_05795	ENOG4105DQU	oxidoreductase, subunit beta
EI285_05815	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
EI285_05820	ENOG4105D60	lipoprotein releasing system transmembrane protein
EI285_05835	ENOG4105E9K	Isocitrate dehydrogenase
EI285_05860	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
EI285_05870	ENOG410841J	DNA-binding protein Hu
EI285_05885	ENOG4105E1F	short-chain dehydrogenase reductase
EI285_05890	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
EI285_05895	ENOG4106H78	methyltransferase
EI285_05900	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
EI285_05915	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
EI285_05930	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
EI285_05935	ENOG4107TS3	membrane protein, TerC
EI285_05940	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
EI285_05950	ENOG4105BZU	Histidine kinase
EI285_05955	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
EI285_05980	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
EI285_05985	ENOG4105CIY	formyltetrahydrofolate deformylase
EI285_05990	ENOG4105C6K	Malic enzyme
EI285_05995	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
EI285_06000	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
EI285_06005	ENOG4105E2X	shikimate dehydrogenase
EI285_06035	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
EI285_06085	ENOG4105D00	flagellar biosynthetic protein flhB
EI285_06110	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
EI285_06120	ENOG4105DWV	Homoserine O-trans-acetylase
EI285_06130	ENOG4105CUC	YeeE YedE family protein
EI285_06135	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
EI285_06140	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
EI285_06150	ENOG4105C7H	Helicase, RecD TraA family
EI285_06160	ENOG4105C1J	atp-dependent rna helicase
EI285_06170	ENOG4106032	Glutathionylspermidine synthase
EI285_06180	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
EI285_06190	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
EI285_06195	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
EI285_06200	ENOG410624X	efflux transporter, rnd family, mfp subunit
EI285_06210	ENOG4105M8K	biopolymer transport protein
EI285_06215	ENOG4105M15	transport protein ExbD
EI285_06225	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
EI285_06235	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
EI285_06240	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
EI285_06250	ENOG4105C28	cystathionine
EI285_06265	ENOG4105D7X	high-affinity nickel-transporter
EI285_06270	ENOG4105DSE	periplasmic solute binding protein
EI285_06280	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
EI285_06285	ENOG410692R	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
EI285_06295	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
EI285_06305	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
EI285_06320	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
EI285_06325	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
EI285_06330	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
EI285_06335	ENOG4105C3F	Signal peptidase i
EI285_06340	ENOG4108YZG	isomerase
EI285_06355	ENOG4105CSM	endonuclease III
EI285_06360	ENOG4105BZU	Histidine kinase
EI285_06370	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
EI285_06380	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
EI285_06385	ENOG4105CUZ	uba thif-type nad fad binding protein
EI285_06390	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EI285_06395	ENOG4105CH7	arginosuccinase
EI285_06400	ENOG4105BZU	Histidine kinase
EI285_06405	ENOG4105CJW	magnesium transporter
EI285_06420	ENOG4105C3K	feS assembly ATPase SufC
EI285_06425	ENOG4105DIW	FeS assembly protein SUFB
EI285_06430	ENOG4105C9B	Cysteine desulfurase
EI285_06435	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
EI285_06455	ENOG4105YIC	Major outer membrane protein
EI285_06460	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
EI285_06470	ENOG4107SDU	Methyl-accepting chemotaxis
EI285_06480	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
EI285_06490	ENOG4105II7	pyrroline-5-carboxylate reductase
EI285_06510	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
EI285_06515	ENOG4107RDB	Major Facilitator
EI285_06535	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
EI285_06555	ENOG4105C5F	glutamine synthetase
EI285_06565	ENOG4108ZEX	molybdopterin converting factor, subunit 2
EI285_06575	ENOG4108XUR	Pfam:DUF178
EI285_06580	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
EI285_06590	ENOG4105CNI	cell division protein FtsW
EI285_06595	ENOG4105CJN	penicillin-binding protein
EI285_06600	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
EI285_06645	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
EI285_06655	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
EI285_06670	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
EI285_06680	ENOG4105VB9	50S ribosomal protein l28
EI285_06690	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
EI285_06695	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
EI285_06700	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
EI285_06705	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
EI285_06715	ENOG4105E0M	Sulfatase
EI285_06735	ENOG4106WTF	Glycosyl transferase, family 2
EI285_06740	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
EI285_06765	ENOG4108ST3	glycosyltransferase
EI285_06770	ENOG41080IJ	Diacylglycerol kinase
EI285_06780	ENOG4105DKP	glycosyl transferase, family 9
EI285_06790	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
EI285_06810	ENOG4105GVR	general secretion pathway protein D
EI285_06820	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
EI285_06830	ENOG4105CPF	Cell wall formation (By similarity)
EI285_06835	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
EI285_06840	ENOG4105C8Q	Methyl-accepting chemotaxis
EI285_06850	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
EI285_06855	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
EI285_06860	ENOG4105NBK	UPF0345 protein
EI285_06875	ENOG4108HU6	Metal dependent phosphohydrolase
EI285_06880	ENOG4105C3G	gtp-binding protein
EI285_06885	ENOG4105D22	carbon starvation protein
EI285_06910	ENOG4108VAU	general secretion pathway protein G
EI285_06915	ENOG4105CDU	Replicative dna helicase
EI285_06920	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
EI285_06925	ENOG4105C08	Histidine kinase
EI285_06935	ENOG4105CRK	lysyL-tRNA synthetase
EI285_06940	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
EI285_06950	ENOG4105CRQ	synthase (Component I)
EI285_06955	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
EI285_06960	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
EI285_06970	ENOG4105BZU	Histidine kinase
EI285_06975	ENOG4105D0M	Protease HtpX homolog
EI285_06990	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
EI285_07000	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
EI285_07005	ENOG4108512	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
EI285_07015	ENOG4105VG0	50S ribosomal protein l34
EI285_07020	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
EI285_07025	ENOG4105C5H	ABC transporter
EI285_07035	ENOG4108RCM	Nitroreductase
EI285_07040	ENOG4105NF4	modulator of drug activity
EI285_07055	ENOG4105HMI	Membrane
EI285_07060	ENOG4105DUM	transcriptional regulator, lysR family
EI285_07075	ENOG4105US7	Histidine kinase
EI285_07090	ENOG4105NQN	cytochrome C
EI285_07135	ENOG4105F4G	Membrane
EI285_07140	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
EI285_07145	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
EI285_07150	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
EI285_07155	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
EI285_07160	ENOG4105CE1	Ferrous iron transport protein b
EI285_07180	ENOG4105EUJ	GTP cyclohydrolase i
EI285_07185	ENOG4105D7N	magnesium and cobalt transport protein CorA
EI285_07190	ENOG4105D7Q	type ii secretion system
EI285_07195	ENOG4107QHF	type ii secretion system protein e
EI285_07210	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
EI285_07215	ENOG4105C0P	Mg chelatase subunit ChlI
EI285_07220	ENOG4105C8Q	Methyl-accepting chemotaxis
EI285_07225	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
EI285_07235	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
EI285_07240	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
EI285_07245	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
EI285_07250	ENOG4105CSR	polyphosphate kinase 2
EI285_07255	ENOG4105CSR	polyphosphate kinase 2
EI285_07365	ENOG4107QMH	DNA methylase
EI285_07395	ENOG4105DFS	Conserved Protein
EI285_07400	ENOG4105D85	methylase
EI285_07435	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EI285_07440	ENOG4105C8Q	Methyl-accepting chemotaxis
EI285_07450	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
EI285_07455	ENOG4105BZU	Histidine kinase
EI285_07465	ENOG4105H4F	exported protein
EI285_07470	ENOG4105DHQ	Histidine kinase
EI285_07475	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
EI285_07600	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
EI285_07605	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
EI285_07610	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
EI285_07625	ENOG4105DJG	MaoC domain protein dehydratase
EI285_07660	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
EI285_07670	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
EI285_07675	ENOG4105IGJ	Zn-dependent Hydrolase of the beta-lactamase fold protein
EI285_07680	ENOG4105ECQ	AraC Family Transcriptional Regulator
EI285_07685	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
EI285_07690	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
EI285_07695	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
EI285_07700	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
EI285_07705	ENOG4108JQ7	(ABC) transporter
EI285_07720	ENOG4105C59	p-type ATPase
EI285_07725	ENOG4108M8H	domain protein
EI285_07730	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
EI285_07740	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
EI285_07745	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
EI285_07750	ENOG4105CE9	30S ribosomal protein S2
EI285_07755	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
EI285_07770	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
EI285_07775	ENOG4107RSR	Malate quinone oxidoreductase
EI285_07780	ENOG4105CEV	competence damage-inducible protein
EI285_07805	ENOG4105BZU	Histidine kinase
EI285_07810	ENOG4108STX	response regulator
EI285_07825	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
EI285_07835	ENOG4107QN1	sodium solute
EI285_07845	ENOG4107QN1	sodium solute
EI285_07855	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
EI285_07865	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
EI285_07870	ENOG4108IJ2	phosphate acetyltransferase
EI285_07885	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
EI285_07890	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
EI285_07895	ENOG4105DC7	peptidase M24
EI285_07900	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EI285_07905	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
EI285_07910	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
EI285_07915	ENOG4107XWI	flavin reductase domain protein, FMN-binding
EI285_07925	ENOG4105D7B	Flagellar biosynthesis protein flha
EI285_07935	ENOG4108JIR	Flagellum-specific ATP synthase
EI285_07945	ENOG4105D00	flagellar biosynthetic protein flhB
EI285_07960	ENOG4108ZC9	flagellar basal-body rod protein flgc
EI285_07975	ENOG4107R21	site-determining protein
EI285_07980	ENOG4105FZW	flagellar biosynthesis regulator FlhF
EI285_08000	ENOG4105DD5	Flagellar motor switch protein
EI285_08030	ENOG4105BZE	flagellar hook protein, FlgE
EI285_08040	ENOG4105DD5	Flagellar motor switch protein
EI285_08050	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
EI285_08055	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
EI285_08060	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
EI285_08065	ENOG4105KTQ	flagellar basal-body rod protein
EI285_08080	ENOG4105CGA	flagellar basal-body rod protein FlgG
EI285_08095	ENOG4105V3S	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
EI285_08105	ENOG4105K5M	30s ribosomal protein S16
EI285_08110	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EI285_08115	ENOG4105EI2	Pseudouridine synthase
EI285_08120	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
EI285_08130	ENOG4105EGD	dinuclear metal center protein, YbgI family
EI285_08135	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
EI285_08145	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
EI285_08155	ENOG4105CFP	Peptidase U32
EI285_08160	ENOG41080BE	Methyl-accepting chemotaxis sensory transducer
EI285_08160	ENOG41080BE	Methyl-accepting chemotaxis sensory transducer
EI285_08165	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
EI285_08170	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
EI285_08175	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
EI285_08180	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
EI285_08185	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
EI285_08200	ENOG4105DDQ	anthranilate synthase
EI285_08215	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EI285_08235	ENOG4105K89	arsenate reductase
EI285_08240	ENOG4105CHJ	isochorismatase hydrolase
EI285_08250	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
EI285_08255	ENOG4107ZQN	disulfide bond
EI285_08260	ENOG4107QMP	dna polymerase iii subunits gamma and tau
EI285_08265	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
EI285_08270	ENOG4105D82	Glutamate dehydrogenase
EI285_08275	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
EI285_08280	ENOG4105D3R	alkyl hydroperoxide reductase
EI285_08290	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
EI285_08300	ENOG4105YQ2	50s ribosomal protein l32
EI285_08305	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
EI285_08310	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
EI285_08330	ENOG4105E33	succinate dehydrogenase
EI285_08335	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
EI285_08340	ENOG4108S24	Fumarate reduCtase
EI285_08345	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
EI285_08350	ENOG4105C8S	subunit m
EI285_08355	ENOG4105D65	subunit l
EI285_08360	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
EI285_08365	ENOG4107UFS	subunit j
EI285_08375	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
EI285_08380	ENOG4108IEH	NADH dehydrogenase subunit g
EI285_08385	ENOG4105BZN	citrate synthase
EI285_08395	ENOG4105GKE	subunit e
EI285_08400	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
EI285_08405	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
EI285_08410	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EI285_08415	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
EI285_08430	ENOG4107XM3	UPF0442 protein
EI285_08435	ENOG4107XM3	UPF0442 protein
EI285_08445	ENOG4108VHG	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
EI285_08450	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
EI285_08460	ENOG4105C8Q	Methyl-accepting chemotaxis
EI285_08480	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
EI285_08485	ENOG4105C5I	Dehydrogenase
EI285_08495	ENOG4105CR4	methylisocitrate lyase
EI285_08500	ENOG4105BZN	citrate synthase
EI285_08505	ENOG4108I0Z	Aconitate hydratase
EI285_08510	ENOG4105C7F	AcnD-accessory protein PrpF
EI285_08515	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
EI285_08530	ENOG41082UM	UPF0102 protein
EI285_08535	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
EI285_08550	ENOG4105DVY	radical SAM domain protein
EI285_08560	ENOG4105KB8	(LipO)protein
EI285_08565	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
EI285_08575	ENOG4105CHV	Transcription elongation factor NusA
EI285_08580	ENOG4105C8N	cysteinyl-tRNA synthetase
EI285_08585	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
EI285_08590	ENOG4108UUM	single-stranded DNA-binding protein
EI285_08595	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
EI285_08610	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
EI285_08615	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
EI285_08630	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
EI285_08635	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
EI285_08640	ENOG4105C3M	thioredoxin reductase
EI285_08650	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
EI285_08660	ENOG4105D05	Receptor
EI285_08665	ENOG4105DHQ	Histidine kinase
EI285_08670	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
EI285_08675	ENOG4105C0H	protease
EI285_08680	ENOG4105C01	Dihydroxy-acid dehydratase
EI285_08700	ENOG4105SCY	DNAK suppressor
EI285_08705	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
EI285_08710	ENOG4108TX7	
EI285_08720	ENOG4105CN1	protease
EI285_08725	ENOG4105C8V	SAICAR synthetase
EI285_08730	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
EI285_08735	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
EI285_08745	ENOG4105E9Q	Acyl-transferase
EI285_08755	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
EI285_08760	ENOG4105C75	arginyL-tRNA synthetase
EI285_08770	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
EI285_08775	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
EI285_08780	ENOG4105BZA	Phosphoglycerate kinase
EI285_08785	ENOG4105CP7	Triose-phosphate isomerase
EI285_08790	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
EI285_08795	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
EI285_08800	ENOG4105CQC	Prephenate dehydratase
EI285_08805	ENOG4105CIH	Imidazole acetol-phosphate transaminase
EI285_08810	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
EI285_08815	ENOG4105CA0	peroxidase
EI285_08825	ENOG4107YJQ	MAF-like protein
EI285_08835	ENOG4107QPK	)-transporter
EI285_08865	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EI285_08870	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
EI285_08875	ENOG4105K63	Thioredoxin
EI285_08880	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
EI285_08895	ENOG4105BZU	Histidine kinase
EI285_08915	ENOG4105CA3	membrane-bound lytic murein transglycosylase
EI285_08920	ENOG4105CFG	Acts as a chaperone (By similarity)
EI285_08925	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EI285_08965	ENOG4105C45	hydrogenase expression formation protein (HypE)
EI285_08970	ENOG4105CQS	hydrogenase expression formation protein HypD
EI285_08975	ENOG4105WRB	Hydrogenase assembly chaperone hypC hupF
EI285_08980	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
EI285_08995	ENOG4108P97	
EI285_09000	ENOG4108USZ	hydrogenase
EI285_09005	ENOG4105X7T	Ni Fe-hydrogenase, b-type cytochrome subunit
EI285_09010	ENOG4105DPX	Hydrogenase, large subunit
EI285_09015	ENOG4105E3S	small subunit
EI285_09020	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
EI285_09035	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
EI285_09040	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
EI285_09045	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
EI285_09060	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
EI285_09065	ENOG4105I03	Flagellin
EI285_09070	ENOG4105I03	Flagellin
EI285_09150	ENOG4105D2T	synthase
EI285_09155	ENOG4105C5X	domain protein
EI285_09175	ENOG4108P1X	synthase
EI285_09180	ENOG4105EMU	Dehydrogenase
EI285_09185	ENOG4105CHR	reductase
EI285_09200	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
EI285_09210	ENOG4105F0R	Cytidylyltransferase
EI285_09215	ENOG4105CB5	ATP-dependent DNA helicase recG
EI285_09220	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
EI285_09225	ENOG4105C5E	polysaccharide biosynthesis protein
EI285_09235	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
EI285_09240	ENOG4105C8J	)-transporter
EI285_09245	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
EI285_09250	ENOG4105CHH	sulfate transporter
EI285_09260	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
EI285_09270	ENOG4105E63	Pfam:DUF178
EI285_09275	ENOG4105D4A	Cell wall formation (By similarity)
EI285_09295	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
EI285_09300	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
EI285_09315	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
EI285_09330	ENOG4105DFF	Rod shape-determining protein mreb
EI285_09335	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
EI285_09340	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
EI285_09345	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
EI285_09350	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
EI285_09355	ENOG4105WPN	DNA integration recombination invertion protein
EI285_09390	ENOG4105HFZ	Membrane
EI285_09395	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
EI285_09405	ENOG4105NU9	Preprotein translocase subunit SecG
EI285_09410	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
EI285_09415	ENOG4107VCP	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
EI285_09435	ENOG410802Z	Protein of unknown function (DUF328)
EI285_09450	ENOG4107RES	phosphoglycerol transferase I
EI285_09470	ENOG410802Z	Protein of unknown function (DUF328)
EI285_09500	ENOG410802Z	Protein of unknown function (DUF328)
EI285_09520	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
EI285_09525	ENOG4105C26	Dehydrogenase
EI285_09530	ENOG4105C7K	acetolactate synthase
EI285_09535	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
EI285_09540	ENOG4108RMU	ferritin dps family protein
EI285_09545	ENOG4105C2C	drug resistance transporter, Bcr CflA
EI285_09560	ENOG4105BZU	Histidine kinase
EI285_09565	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
EI285_09570	ENOG4105BZS	acriflavin resistance protein
EI285_09585	ENOG4105C8Q	Methyl-accepting chemotaxis
EI285_09590	ENOG4105CBX	hi0933 family
EI285_09610	ENOG4105C6T	cysteine synthase
EI285_09620	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
EI285_09625	ENOG4105C11	sulfate adenylyltransferase), subunit 2
EI285_09630	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
EI285_09640	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
EI285_09650	ENOG4105C9B	Cysteine desulfurase
EI285_09660	ENOG4105DIN	metallophosphoesterase
EI285_09680	ENOG4105W3S	hemerythrin-like, metal-binding protein
EI285_09685	ENOG4108IJ6	ABC transporter
EI285_09695	ENOG4107Z6A	sulfate abc transporter permease
EI285_09700	ENOG4105C8Q	Methyl-accepting chemotaxis
EI285_09705	ENOG4105BZU	Histidine kinase
EI285_09715	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
EI285_09720	ENOG4105VN1	Heat shock protein
EI285_09730	ENOG4105CI3	gtp-binding protein typa
EI285_09735	ENOG41066VF	YeeE YedE family protein
EI285_09740	ENOG4105KSU	Redox protein
EI285_09745	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
EI285_09750	ENOG4105EN6	Membrane
EI285_09760	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
EI285_09765	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)