locus-tag	class	description
LPB137_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LPB137_00010	COG0592	DNA-directed DNA polymerase activity
LPB137_00015	COG0187	DNA topoisomerase II activity
LPB137_00025	COG0492	ferredoxin-NADP+ reductase activity
LPB137_00030	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LPB137_00040	COG0697	spore germination
LPB137_00050	COG0564	pseudouridine synthase activity
LPB137_00055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LPB137_00060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPB137_00065	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPB137_00130	COG2207	Transcriptional regulator
LPB137_00130	COG4753	response regulator
LPB137_00135	COG4191	Histidine kinase
LPB137_00140	COG0348	domain, Protein
LPB137_00145	COG3706	GGDEF domain
LPB137_00155	COG2169	Transcriptional regulator
LPB137_00155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LPB137_00160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LPB137_00165	COG3706	GGDEF domain
LPB137_00170	COG1280	lysine exporter protein (LysE YggA)
LPB137_00175	COG3287	FIST C domain
LPB137_00175	COG2200	EAL domain
LPB137_00175	COG2199	diguanylate cyclase activity
LPB137_00180	COG3869	Catalyzes the specific phosphorylation of arginine residues in
LPB137_00190	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LPB137_00195	COG0604	alcohol dehydrogenase
LPB137_00200	COG1733	regulation of RNA biosynthetic process
LPB137_00205	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LPB137_00220	COG0247	lactate metabolic process
LPB137_00235	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LPB137_00240	COG0745	RESPONSE REGULATOR receiver
LPB137_00245	COG3852	Histidine kinase
LPB137_00250	COG1556	Lactate utilization protein
LPB137_00255	COG1139	Iron-sulfur cluster binding protein
LPB137_00260	COG0247	lactate metabolic process
LPB137_00280	COG0439	Biotin carboxylase
LPB137_00285	COG0513	Belongs to the DEAD box helicase family
LPB137_00290	COG0306	phosphate transporter
LPB137_00300	COG0367	asparagine synthase
LPB137_00310	COG0778	Nitroreductase
LPB137_00315	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LPB137_00325	COG1053	succinate dehydrogenase
LPB137_00335	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LPB137_00345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LPB137_00345	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LPB137_00350	COG1187	pseudouridine synthase activity
LPB137_00355	COG0517	IMP dehydrogenase activity
LPB137_00355	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LPB137_00365	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LPB137_00370	COG0107	imidazoleglycerol-phosphate synthase activity
LPB137_00385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LPB137_00390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPB137_00400	COG3850	Histidine kinase
LPB137_00400	COG5002	protein histidine kinase activity
LPB137_00420	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPB137_00430	COG3220	belongs to the UPF0276 family
LPB137_00445	COG0534	Mate efflux family protein
LPB137_00450	COG0460	homoserine dehydrogenase
LPB137_00455	COG0436	Aminotransferase
LPB137_00470	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LPB137_00475	COG0254	rRNA binding
LPB137_00480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LPB137_00495	COG3047	cAMP biosynthetic process
LPB137_00495	COG2885	chlorophyll binding
LPB137_00510	COG2826	transposase and inactivated derivatives, IS30 family
LPB137_00575	COG1395	domain, Protein
LPB137_00590	COG4974	Belongs to the 'phage' integrase family
LPB137_00610	COG1061	Type III restriction enzyme res subunit
LPB137_00615	COG1028	Short-chain dehydrogenase reductase Sdr
LPB137_00615	COG0318	PFAM AMP-dependent synthetase and ligase
LPB137_00615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LPB137_00615	COG0300	oxidoreductase activity
LPB137_00615	COG3321	synthase
LPB137_00700	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LPB137_00710	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LPB137_00715	COG0237	dephospho-CoA kinase activity
LPB137_00720	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LPB137_00725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LPB137_00735	COG1280	lysine exporter protein (LysE YggA)
LPB137_00740	COG1309	transcriptional regulator
LPB137_00745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPB137_00755	COG1301	dicarboxylic acid transport
LPB137_00760	COG2353	YceI-like domain
LPB137_00765	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LPB137_00770	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LPB137_00775	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LPB137_00785	COG0505	Belongs to the CarA family
LPB137_00800	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LPB137_00800	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LPB137_00815	COG0348	domain, Protein
LPB137_00815	COG3901	Regulator of nitric oxide reductase transcription
LPB137_00820	COG0489	protein tyrosine kinase activity
LPB137_00825	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LPB137_00825	COG0140	phosphoribosyl-ATP diphosphatase activity
LPB137_00850	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LPB137_00865	COG1410	methionine synthase
LPB137_00865	COG0646	methionine synthase
LPB137_00870	COG0697	spore germination
LPB137_00905	COG0450	alkyl hydroperoxide reductase
LPB137_00925	COG1979	alcohol dehydrogenase
LPB137_00930	COG2207	Transcriptional regulator
LPB137_00940	COG1253	flavin adenine dinucleotide binding
LPB137_00960	COG1854	S-ribosylhomocysteine lyase activity
LPB137_00970	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LPB137_00975	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LPB137_00975	COG3608	succinylglutamate desuccinylase aspartoacylase
LPB137_00995	COG1335	isochorismatase
LPB137_01000	COG3180	Ammonia monooxygenase
LPB137_01005	COG0840	transmembrane signaling receptor activity
LPB137_01005	COG0840	transmembrane signaling receptor activity
LPB137_01010	COG1013	pyruvate-flavodoxin oxidoreductase activity
LPB137_01015	COG0674	pyruvate-flavodoxin oxidoreductase activity
LPB137_01025	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LPB137_01030	COG0546	phosphoglycolate phosphatase activity
LPB137_01040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LPB137_01045	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LPB137_01050	COG5002	protein histidine kinase activity
LPB137_01070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LPB137_01075	COG0581	inorganic phosphate transmembrane transporter activity
LPB137_01080	COG0573	inorganic phosphate transmembrane transporter activity
LPB137_01095	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LPB137_01100	COG0268	Binds directly to 16S ribosomal RNA
LPB137_01105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPB137_01110	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LPB137_01115	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LPB137_01125	COG0446	pyridine nucleotide-disulphide oxidoreductase
LPB137_01140	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LPB137_01145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LPB137_01150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LPB137_01155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LPB137_01180	COG0575	Belongs to the CDS family
LPB137_01185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LPB137_01205	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LPB137_01210	COG0023	Translation Initiation Factor
LPB137_01225	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LPB137_01225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LPB137_01310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LPB137_01355	COG0745	RESPONSE REGULATOR receiver
LPB137_01395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LPB137_01410	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
LPB137_01430	COG0840	transmembrane signaling receptor activity
LPB137_01440	COG3040	lipid binding
LPB137_01445	COG0415	Belongs to the DNA photolyase family
LPB137_01450	COG3046	protein related to deoxyribodipyrimidine photolyase
LPB137_01460	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LPB137_01470	COG1090	epimerase
LPB137_01475	COG3852	Histidine kinase
LPB137_01480	COG3279	Response regulator of the LytR AlgR family
LPB137_01485	COG3275	phosphorelay sensor kinase activity
LPB137_01490	COG1233	COG1233 Phytoene dehydrogenase and related
LPB137_01515	COG4191	Histidine kinase
LPB137_01520	COG4191	Histidine kinase
LPB137_01520	COG0784	Response regulator, receiver
LPB137_01530	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LPB137_01545	COG0577	efflux transmembrane transporter activity
LPB137_01545	COG1136	(ABC) transporter
LPB137_01560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LPB137_01575	COG0793	Belongs to the peptidase S41A family
LPB137_01580	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LPB137_01585	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LPB137_01590	COG0047	phosphoribosylformylglycinamidine synthase activity
LPB137_01600	COG0204	Acyl-transferase
LPB137_01605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LPB137_01610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LPB137_01615	COG0018	arginyl-trna synthetase
LPB137_01625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LPB137_01630	COG0126	phosphoglycerate kinase activity
LPB137_01635	COG0149	triose-phosphate isomerase activity
LPB137_01640	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LPB137_01645	COG0019	diaminopimelate decarboxylase activity
LPB137_01650	COG0077	Prephenate dehydratase
LPB137_01650	COG1605	Chorismate mutase
LPB137_01655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LPB137_01660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LPB137_01680	COG0840	transmembrane signaling receptor activity
LPB137_01690	COG0424	maF-like protein
LPB137_01705	COG0697	spore germination
LPB137_01715	COG0791	NLP P60 protein
LPB137_01720	COG0791	NLP P60 protein
LPB137_01740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LPB137_01745	COG3118	belongs to the thioredoxin family
LPB137_01755	COG2205	protein histidine kinase activity
LPB137_01755	COG0745	RESPONSE REGULATOR receiver
LPB137_01755	COG4191	Histidine kinase
LPB137_01760	COG0745	RESPONSE REGULATOR receiver
LPB137_01765	COG0492	ferredoxin-NADP+ reductase activity
LPB137_01770	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LPB137_01775	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LPB137_01780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPB137_01780	COG3153	acetyltransferase
LPB137_01790	COG0210	DNA helicase
LPB137_01795	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LPB137_01800	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LPB137_01805	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LPB137_01810	COG3278	Belongs to the heme-copper respiratory oxidase family
LPB137_01850	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LPB137_01870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LPB137_01880	COG0157	Belongs to the NadC ModD family
LPB137_01885	COG2404	hydrolase activity, acting on ester bonds
LPB137_01895	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LPB137_01905	COG0083	homoserine kinase activity
LPB137_01915	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LPB137_01920	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LPB137_01925	COG0779	Required for maturation of 30S ribosomal subunits
LPB137_01935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LPB137_01940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LPB137_01945	COG1185	polyribonucleotide nucleotidyltransferase activity
LPB137_01945	COG0539	negative regulation of cytoplasmic translation
LPB137_01950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LPB137_01955	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LPB137_01960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPB137_01960	COG0072	phenylalanine-tRNA ligase activity
LPB137_01965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LPB137_01970	COG0537	adenosine 5'-monophosphoramidase activity
LPB137_01975	COG0825	malonyl-CoA metabolic process
LPB137_01980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPB137_01985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LPB137_01990	COG1028	Short-chain dehydrogenase reductase Sdr
LPB137_01995	COG0602	queuosine metabolic process
LPB137_02005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LPB137_02010	COG0303	'Molybdopterin
LPB137_02025	COG2010	Cytochrome c
LPB137_02030	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LPB137_02040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LPB137_02045	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LPB137_02050	COG1074	ATP-dependent DNA helicase activity
LPB137_02055	COG0356	it plays a direct role in the translocation of protons across the membrane
LPB137_02060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LPB137_02065	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LPB137_02075	COG0336	Belongs to the RNA methyltransferase TrmD family
LPB137_02080	COG0335	large ribosomal subunit rRNA binding
LPB137_02100	COG1119	ATPase activity
LPB137_02120	COG2423	ornithine cyclodeaminase activity
LPB137_02125	COG3938	Belongs to the proline racemase family
LPB137_02140	COG4215	(ABC) transporter
LPB137_02145	COG0765	amino acid transport
LPB137_02150	COG1126	abc transporter atp-binding protein
LPB137_02205	COG0410	ABC transporter
LPB137_02210	COG1012	belongs to the aldehyde dehydrogenase family
LPB137_02240	COG0010	Belongs to the arginase family
LPB137_02250	COG3610	response to peptide
LPB137_02255	COG2966	Psort location CytoplasmicMembrane, score
LPB137_02270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LPB137_02290	COG2885	chlorophyll binding
LPB137_02305	COG2200	EAL domain
LPB137_02315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPB137_02320	COG2909	trisaccharide binding
LPB137_02325	COG0180	Tryptophanyl-tRNA synthetase
LPB137_02340	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LPB137_02345	COG2205	protein histidine kinase activity
LPB137_02350	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LPB137_02370	COG0840	transmembrane signaling receptor activity
LPB137_02390	COG3043	anaerobic respiration
LPB137_02395	COG0348	domain, Protein
LPB137_02400	COG0437	4 iron, 4 sulfur cluster binding
LPB137_02405	COG0243	molybdopterin cofactor binding
LPB137_02410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LPB137_02415	COG1280	lysine exporter protein (LysE YggA)
LPB137_02430	COG1126	abc transporter atp-binding protein
LPB137_02435	COG0765	amino acid transport
LPB137_02440	COG4597	amino acid ABC transporter
LPB137_02445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPB137_02470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LPB137_02470	COG1648	precorrin-2 dehydrogenase activity
LPB137_02480	COG0535	radical SAM domain protein
LPB137_02535	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LPB137_02540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LPB137_02550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LPB137_02560	COG2404	hydrolase activity, acting on ester bonds
LPB137_02570	COG0189	ligase activity
LPB137_02580	COG2239	Acts as a magnesium transporter
LPB137_02590	COG0189	ligase activity
LPB137_02590	COG4067	protein conserved in archaea
LPB137_02610	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LPB137_02610	COG3264	Mechanosensitive ion channel
LPB137_02615	COG1832	CoA-binding protein
LPB137_02620	COG0642	Histidine kinase
LPB137_02625	COG0745	RESPONSE REGULATOR receiver
LPB137_02630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LPB137_02635	COG0191	fructose-bisphosphate aldolase activity
LPB137_02645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LPB137_02665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LPB137_02670	COG1116	anion transmembrane transporter activity
LPB137_02690	COG3842	ATPase activity
LPB137_02710	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LPB137_02725	COG0535	radical SAM domain protein
LPB137_02745	COG2205	protein histidine kinase activity
LPB137_02745	COG2198	Histidine kinase
LPB137_02745	COG0784	Response regulator, receiver
LPB137_02745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPB137_02750	COG1012	belongs to the aldehyde dehydrogenase family
LPB137_02765	COG0811	peptide transport
LPB137_02780	COG4191	Histidine kinase
LPB137_02790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LPB137_02800	COG0142	geranyltranstransferase activity
LPB137_02805	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LPB137_02810	COG0442	prolyl-tRNA aminoacylation
LPB137_02815	COG0668	transmembrane transport
LPB137_02820	COG0617	tRNA 3'-terminal CCA addition
LPB137_02830	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LPB137_02835	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LPB137_02845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPB137_02850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPB137_02865	COG0495	leucyl-tRNA aminoacylation
LPB137_02875	COG0285	dihydrofolate synthase activity
LPB137_02880	COG0739	heme binding
LPB137_02915	COG2308	Evidence 4 Homologs of previously reported genes of
LPB137_02930	COG2308	Evidence 4 Homologs of previously reported genes of
LPB137_02950	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LPB137_02960	COG2081	HI0933 family
LPB137_02980	COG0745	RESPONSE REGULATOR receiver
LPB137_02990	COG2081	HI0933 family
LPB137_02995	COG1692	metallophosphoesterase
LPB137_03015	COG2226	methyltransferase
LPB137_03020	COG1570	exodeoxyribonuclease VII activity
LPB137_03025	COG0835	chemotaxis
LPB137_03035	COG2204	response regulator
LPB137_03040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LPB137_03050	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LPB137_03055	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LPB137_03070	COG0459	protein refolding
LPB137_03075	COG3706	GGDEF domain
LPB137_03100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPB137_03105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LPB137_03110	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LPB137_03115	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LPB137_03120	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LPB137_03130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPB137_03135	COG2264	protein methyltransferase activity
LPB137_03140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LPB137_03150	COG4191	Histidine kinase
LPB137_03155	COG2203	Gaf domain
LPB137_03155	COG3706	GGDEF domain
LPB137_03155	COG4251	negative regulation of phosphorylation
LPB137_03155	COG5001	Diguanylate cyclase
LPB137_03160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LPB137_03180	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LPB137_03200	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LPB137_03205	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LPB137_03215	COG0481	GTPase activity
LPB137_03230	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPB137_03240	COG0482	sulfurtransferase activity
LPB137_03245	COG0482	sulfurtransferase activity
LPB137_03250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LPB137_03255	COG0006	proline dipeptidase activity
LPB137_03260	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LPB137_03265	COG0402	S-adenosylhomocysteine deaminase activity
LPB137_03270	COG0616	signal peptide processing
LPB137_03280	COG0280	phosphate acetyltransferase
LPB137_03285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPB137_03325	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LPB137_03335	COG0745	RESPONSE REGULATOR receiver
LPB137_03340	COG5002	protein histidine kinase activity
LPB137_03430	COG1058	Belongs to the CinA family
LPB137_03430	COG1546	Belongs to the CinA family
LPB137_03435	COG0579	oxidoreductase
LPB137_03440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LPB137_03455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LPB137_03480	COG0714	Associated with various cellular activities
LPB137_03490	COG0052	Belongs to the universal ribosomal protein uS2 family
LPB137_03495	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LPB137_03500	COG1136	(ABC) transporter
LPB137_03510	COG0194	GDP metabolic process
LPB137_03520	COG2217	Heavy metal translocating P-type atpase
LPB137_03535	COG4608	Belongs to the ABC transporter superfamily
LPB137_03540	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LPB137_03550	COG1355	regulation of microtubule-based process
LPB137_03555	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LPB137_03560	COG1121	(ABC) transporter
LPB137_03565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LPB137_03575	COG2996	Protein conserved in bacteria
LPB137_03580	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LPB137_03590	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LPB137_03595	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LPB137_03600	COG0210	DNA helicase
LPB137_03610	COG0525	valine-tRNA ligase activity
LPB137_03620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPB137_03645	COG1119	ATPase activity
LPB137_03660	COG2814	Major facilitator Superfamily
LPB137_03665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LPB137_03685	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LPB137_03690	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPB137_03695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LPB137_03715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LPB137_03740	COG0668	transmembrane transport
LPB137_03765	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LPB137_03800	COG1858	cytochrome C peroxidase
LPB137_03810	COG4191	Histidine kinase
LPB137_03810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPB137_03815	COG1028	Short-chain dehydrogenase reductase Sdr
LPB137_03820	COG0840	transmembrane signaling receptor activity
LPB137_03845	COG2207	Transcriptional regulator
LPB137_03845	COG1917	Cupin 2, conserved barrel domain protein
LPB137_03850	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LPB137_03865	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LPB137_03875	COG0626	cystathionine gamma-synthase activity
LPB137_03880	COG4191	Histidine kinase
LPB137_03895	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LPB137_03905	COG4143	(ABC) transporter
LPB137_03920	COG0039	L-malate dehydrogenase activity
LPB137_03925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LPB137_03930	COG0095	Lipoate-protein ligase
LPB137_03935	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LPB137_03940	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPB137_03945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPB137_03965	COG0585	pseudouridine synthase activity
LPB137_03975	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LPB137_03995	COG3226	Transcriptional regulator
LPB137_04005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPB137_04040	COG2151	metal-sulfur cluster biosynthetic enzyme
LPB137_04045	COG2166	iron-sulfur cluster assembly
LPB137_04050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LPB137_04060	COG0396	ATPase activity
LPB137_04065	COG0719	Fe-S assembly protein
LPB137_04070	COG0765	amino acid transport
LPB137_04085	COG1104	cysteine desulfurase activity
LPB137_04095	COG2239	Acts as a magnesium transporter
LPB137_04115	COG0165	Argininosuccinate lyase
LPB137_04125	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LPB137_04130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPB137_04135	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LPB137_04150	COG2354	Protein conserved in bacteria
LPB137_04155	COG4191	Histidine kinase
LPB137_04155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPB137_04160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPB137_04165	COG0556	nucleotide-excision repair
LPB137_04170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LPB137_04195	COG0698	ribose 5-phosphate isomerase
LPB137_04205	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LPB137_04210	COG0193	aminoacyl-tRNA hydrolase activity
LPB137_04225	COG0860	N-Acetylmuramoyl-L-alanine amidase
LPB137_04235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LPB137_04240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPB137_04250	COG0528	UMP kinase activity
LPB137_04260	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LPB137_04265	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LPB137_04270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPB137_04280	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LPB137_04285	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LPB137_04295	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LPB137_04300	COG0305	Participates in initiation and elongation during chromosome replication
LPB137_04310	COG1793	dna ligase
LPB137_04315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LPB137_04320	COG0133	tryptophan synthase activity
LPB137_04330	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LPB137_04340	COG0784	Response regulator, receiver
LPB137_04340	COG2205	protein histidine kinase activity
LPB137_04345	COG0745	RESPONSE REGULATOR receiver
LPB137_04350	COG0745	RESPONSE REGULATOR receiver
LPB137_04355	COG0784	Response regulator, receiver
LPB137_04355	COG3437	response regulator, receiver
LPB137_04360	COG3437	response regulator, receiver
LPB137_04395	COG0529	Catalyzes the synthesis of activated sulfate
LPB137_04410	COG0450	alkyl hydroperoxide reductase
LPB137_04415	COG2205	protein histidine kinase activity
LPB137_04415	COG0745	RESPONSE REGULATOR receiver
LPB137_04415	COG4191	Histidine kinase
LPB137_04415	COG2205	protein histidine kinase activity
LPB137_04415	COG0745	RESPONSE REGULATOR receiver
LPB137_04415	COG4191	Histidine kinase
LPB137_04425	COG0012	GTP binding
LPB137_04445	COG3123	guanosine phosphorylase activity
LPB137_04460	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LPB137_04465	COG0585	pseudouridine synthase activity
LPB137_04475	COG0840	transmembrane signaling receptor activity
LPB137_04480	COG0632	four-way junction helicase activity
LPB137_04485	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPB137_04495	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LPB137_04510	COG0051	transcription antitermination factor activity, RNA binding
LPB137_04515	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LPB137_04520	COG0088	Forms part of the polypeptide exit tunnel
LPB137_04525	COG0089	rRNA binding
LPB137_04530	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LPB137_04535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LPB137_04540	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LPB137_04545	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LPB137_04550	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LPB137_04555	COG0255	Belongs to the universal ribosomal protein uL29 family
LPB137_04560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LPB137_04565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LPB137_04570	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LPB137_04580	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LPB137_04585	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LPB137_04590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LPB137_04595	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LPB137_04600	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LPB137_04605	COG0200	Binds to the 23S rRNA
LPB137_04610	COG0201	protein transport
LPB137_04615	COG0024	Methionine aminopeptidase
LPB137_04620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LPB137_04630	COG1573	uracil-dna glycosylase
LPB137_04640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LPB137_04655	COG1032	radical SAM domain protein
LPB137_04660	COG0563	adenylate kinase activity
LPB137_04670	COG0840	transmembrane signaling receptor activity
LPB137_04680	COG0322	excinuclease ABC activity
LPB137_04695	COG0386	Belongs to the glutathione peroxidase family
LPB137_04710	COG1733	regulation of RNA biosynthetic process
LPB137_04715	COG0778	Nitroreductase
LPB137_04720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LPB137_04735	COG0484	heat shock protein binding
LPB137_04740	COG1620	l-lactate permease
LPB137_04750	COG0484	heat shock protein binding
LPB137_04775	COG0642	Histidine kinase
LPB137_04780	COG0745	RESPONSE REGULATOR receiver
LPB137_04805	COG0708	Exodeoxyribonuclease III
LPB137_04810	COG3706	GGDEF domain
LPB137_04810	COG0745	RESPONSE REGULATOR receiver
LPB137_04825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LPB137_04855	COG5002	protein histidine kinase activity
LPB137_04860	COG1027	Aspartate ammonia-lyase
LPB137_04870	COG1528	Iron-storage protein
LPB137_04875	COG1227	inorganic diphosphatase activity
LPB137_04880	COG1342	Belongs to the UPF0251 family
LPB137_04890	COG1271	oxidase subunit
LPB137_04895	COG1294	oxidase, subunit
LPB137_04905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPB137_04915	COG0010	Belongs to the arginase family
LPB137_04920	COG4335	DNA alkylation repair
LPB137_04925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LPB137_04940	COG4974	Belongs to the 'phage' integrase family
LPB137_04975	COG5002	protein histidine kinase activity
LPB137_05000	COG0745	RESPONSE REGULATOR receiver
LPB137_05015	COG2217	Heavy metal translocating P-type atpase
LPB137_05020	COG0640	Transcriptional regulator
LPB137_05035	COG2132	Multicopper oxidase
LPB137_05050	COG0640	Transcriptional regulator
LPB137_05075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LPB137_05140	COG2356	endonuclease I
LPB137_05185	COG0210	DNA helicase
LPB137_05275	COG2995	paraquat-inducible protein a
LPB137_05280	COG3008	intermembrane lipid transfer
LPB137_05290	COG4175	Glycine betaine
LPB137_05295	COG4176	ABC-type proline glycine betaine transport system permease component
LPB137_05300	COG2113	Glycine betaine
LPB137_05305	COG2113	Glycine betaine
LPB137_05320	COG1064	alcohol dehydrogenase
LPB137_05335	COG0326	Molecular chaperone. Has ATPase activity
LPB137_05370	COG1611	Belongs to the LOG family
LPB137_05380	COG4753	response regulator
LPB137_05380	COG2207	Transcriptional regulator
LPB137_05385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LPB137_05405	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LPB137_05410	COG1984	allophanate hydrolase subunit 2
LPB137_05425	COG2200	EAL domain
LPB137_05425	COG2199	diguanylate cyclase activity
LPB137_05425	COG3287	FIST C domain
LPB137_05440	COG3300	MHYT domain
LPB137_05440	COG5001	Diguanylate cyclase
LPB137_05445	COG0513	Belongs to the DEAD box helicase family
LPB137_05450	COG0668	transmembrane transport
LPB137_05455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LPB137_05475	COG0259	pyridoxamine-phosphate oxidase activity
LPB137_05480	COG1078	dGTPase activity
LPB137_05485	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LPB137_05545	COG1921	L-seryl-tRNASec selenium transferase activity
LPB137_05550	COG4191	Histidine kinase
LPB137_05555	COG0709	Synthesizes selenophosphate from selenide and ATP
LPB137_05560	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LPB137_05565	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LPB137_05570	COG3639	organic phosphonate transmembrane transporter activity
LPB137_05580	COG2204	response regulator
LPB137_05620	COG0437	4 iron, 4 sulfur cluster binding
LPB137_05630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LPB137_05655	COG2998	abc-type tungstate transport system, permease component
LPB137_05660	COG4662	Binding-protein-dependent transport system inner membrane component
LPB137_05690	COG0791	NLP P60 protein
LPB137_05690	COG1388	LysM domain
LPB137_05715	COG1309	transcriptional regulator
LPB137_05725	COG1187	pseudouridine synthase activity
LPB137_05735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPB137_05760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LPB137_05785	COG0251	oxidation-reduction process
LPB137_05790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LPB137_05795	COG1115	amino acid carrier protein
LPB137_05800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LPB137_05840	COG0328	RNA-DNA hybrid ribonuclease activity
LPB137_05885	COG0745	RESPONSE REGULATOR receiver
LPB137_05910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPB137_05915	COG3437	response regulator, receiver
LPB137_05915	COG0784	Response regulator, receiver
LPB137_05930	COG0784	Response regulator, receiver
LPB137_05930	COG4191	Histidine kinase
LPB137_05940	COG0488	(ABC) transporter
LPB137_05945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPB137_05945	COG4191	Histidine kinase
LPB137_05950	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LPB137_05955	COG4191	Histidine kinase
LPB137_05955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPB137_05965	COG3706	GGDEF domain
LPB137_05970	COG0450	alkyl hydroperoxide reductase
LPB137_05975	COG0492	ferredoxin-NADP+ reductase activity
LPB137_05980	COG3118	belongs to the thioredoxin family
LPB137_05985	COG0840	transmembrane signaling receptor activity
LPB137_06010	COG0513	Belongs to the DEAD box helicase family
LPB137_06025	COG0352	thiamine-phosphate diphosphorylase activity
LPB137_06030	COG0351	phosphomethylpyrimidine kinase
LPB137_06040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LPB137_06045	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LPB137_06050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LPB137_06055	COG1116	anion transmembrane transporter activity
LPB137_06075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LPB137_06090	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LPB137_06115	COG0436	Aminotransferase
LPB137_06120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPB137_06145	COG0739	heme binding
LPB137_06150	COG0217	transcriptional regulatory protein
LPB137_06170	COG0697	spore germination
LPB137_06210	COG1049	propionate catabolic process, 2-methylcitrate cycle
LPB137_06225	COG0301	tRNA thio-modification
LPB137_06225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPB137_06235	COG1858	cytochrome C peroxidase
LPB137_06250	COG2814	Major facilitator Superfamily
LPB137_06260	COG0038	chloride channel
LPB137_06275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPB137_06280	COG0531	amino acid
LPB137_06350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LPB137_06385	COG2171	N-acyltransferase activity
LPB137_06390	COG1331	Highly conserved protein containing a thioredoxin domain
LPB137_06400	COG0488	(ABC) transporter
LPB137_06420	COG1671	Belongs to the UPF0178 family
LPB137_06440	COG2884	Cell division ATP-binding protein ftsE
LPB137_06445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LPB137_06455	COG0564	pseudouridine synthase activity
LPB137_06460	COG0772	Belongs to the SEDS family
LPB137_06480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LPB137_06485	COG3123	guanosine phosphorylase activity
LPB137_06505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPB137_06510	COG0066	3-isopropylmalate dehydratase activity
LPB137_06515	COG0473	3-isopropylmalate dehydrogenase activity
LPB137_06530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LPB137_06535	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LPB137_06540	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LPB137_06545	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LPB137_06550	COG0202	RNA polymerase activity
LPB137_06555	COG0203	ribosomal protein L17
LPB137_06560	COG0154	amidase activity
LPB137_06565	COG0517	IMP dehydrogenase activity
LPB137_06565	COG0516	GMP reductase activity
LPB137_06570	COG2827	Endonuclease containing a URI domain
LPB137_06590	COG2267	carboxylic ester hydrolase activity
LPB137_06600	COG0563	adenylate kinase activity
LPB137_06605	COG3118	belongs to the thioredoxin family
LPB137_06625	COG1047	Peptidyl-prolyl cis-trans
LPB137_06655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LPB137_06665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPB137_06675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LPB137_06680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LPB137_06695	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LPB137_06705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LPB137_06710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LPB137_06720	COG0521	Mo-molybdopterin cofactor biosynthetic process
LPB137_06725	COG1193	negative regulation of DNA recombination
LPB137_06750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPB137_06770	COG2824	Alkylphosphonate utilization operon protein PhnA
LPB137_06780	COG1794	racemase activity, acting on amino acids and derivatives
LPB137_06790	COG0745	RESPONSE REGULATOR receiver
LPB137_06795	COG4191	Histidine kinase
LPB137_06795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPB137_06810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LPB137_06825	COG1733	regulation of RNA biosynthetic process
LPB137_06830	COG2249	NAD(P)H dehydrogenase (quinone) activity
LPB137_06835	COG0778	Nitroreductase
LPB137_06870	COG0488	(ABC) transporter
LPB137_06875	COG1607	acyl-coa hydrolase
LPB137_06880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LPB137_06885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LPB137_06910	COG2195	Cleaves the N-terminal amino acid of tripeptides
LPB137_06915	COG1333	cytochrome c biogenesis protein
LPB137_06915	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LPB137_06920	COG0500	methyltransferase
LPB137_06925	COG2199	diguanylate cyclase activity
LPB137_06930	COG5001	Diguanylate cyclase
LPB137_06930	COG3300	MHYT domain
LPB137_06935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPB137_06955	COG0133	tryptophan synthase activity
LPB137_06960	COG4191	Histidine kinase
LPB137_06960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPB137_06965	COG0484	heat shock protein binding
LPB137_06970	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LPB137_06980	COG4191	Histidine kinase
LPB137_06980	COG0784	Response regulator, receiver
LPB137_06990	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LPB137_06995	COG0137	argininosuccinate synthase activity
LPB137_07005	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LPB137_07010	COG0802	atpase or kinase
LPB137_07015	COG1137	ATPase activity
LPB137_07020	COG3706	GGDEF domain
LPB137_07025	COG2199	diguanylate cyclase activity
LPB137_07025	COG3287	FIST C domain
LPB137_07025	COG2200	EAL domain
LPB137_07030	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LPB137_07035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPB137_07035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPB137_07055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LPB137_07060	COG2181	nitrate reductase activity
LPB137_07060	COG0247	lactate metabolic process
LPB137_07065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LPB137_07070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LPB137_07075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LPB137_07075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPB137_07090	COG0745	RESPONSE REGULATOR receiver
LPB137_07095	COG0840	transmembrane signaling receptor activity
LPB137_07100	COG0113	porphobilinogen synthase activity
LPB137_07105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LPB137_07110	COG0357	Ribosomal RNA small subunit methyltransferase G
LPB137_07135	COG3706	GGDEF domain
LPB137_07140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPB137_07160	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LPB137_07175	COG1136	(ABC) transporter
LPB137_07190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPB137_07225	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LPB137_07230	COG0363	glucosamine-6-phosphate deaminase activity
LPB137_07235	COG0129	dihydroxy-acid dehydratase activity
LPB137_07240	COG0800	Aldolase
LPB137_07245	COG0166	Belongs to the GPI family
LPB137_07255	COG0469	pyruvate kinase activity
LPB137_07260	COG0784	Response regulator, receiver
LPB137_07260	COG5002	protein histidine kinase activity
LPB137_07305	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LPB137_07335	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPB137_07335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPB137_07345	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LPB137_07370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPB137_07375	COG0612	Peptidase, M16
LPB137_07380	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LPB137_07385	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPB137_07390	COG0287	Prephenate dehydrogenase
LPB137_07395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LPB137_07410	COG0527	aspartate kinase activity
LPB137_07415	COG0494	nUDIX hydrolase
LPB137_07420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LPB137_07425	COG2890	protein-(glutamine-N5) methyltransferase activity
LPB137_07430	COG0339	signal peptide processing
LPB137_07445	COG0582	viral genome integration into host DNA
LPB137_07450	COG2201	protein-glutamate methylesterase activity
LPB137_07455	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LPB137_07460	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LPB137_07465	COG0643	Histidine kinase
LPB137_07465	COG2198	Histidine kinase
LPB137_07470	COG0745	RESPONSE REGULATOR receiver
LPB137_07475	COG1185	polyribonucleotide nucleotidyltransferase activity
LPB137_07495	COG0151	Belongs to the GarS family
LPB137_07505	COG0659	secondary active sulfate transmembrane transporter activity
LPB137_07510	COG1160	GTP binding
LPB137_07520	COG1674	ftsk spoiiie
LPB137_07520	COG1196	nuclear chromosome segregation
LPB137_07525	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPB137_07530	COG0440	acetolactate synthase activity
LPB137_07535	COG0028	Belongs to the TPP enzyme family
LPB137_07550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LPB137_07555	COG2203	Gaf domain
LPB137_07555	COG3706	GGDEF domain
LPB137_07555	COG4251	negative regulation of phosphorylation
LPB137_07555	COG5001	Diguanylate cyclase
LPB137_07560	COG0659	secondary active sulfate transmembrane transporter activity
LPB137_07590	COG0037	tRNA processing
LPB137_07615	COG2321	neutral zinc metallopeptidase
LPB137_07625	COG1322	Protein conserved in bacteria
LPB137_07630	COG0501	Belongs to the peptidase M48B family
LPB137_07635	COG3706	GGDEF domain
LPB137_07640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPB137_07645	COG0824	Thioesterase
LPB137_07650	COG0840	transmembrane signaling receptor activity
LPB137_07665	COG0642	Histidine kinase
LPB137_07670	COG2197	response regulator
LPB137_07685	COG0375	protein maturation
LPB137_07690	COG1024	Enoyl-CoA hydratase
LPB137_07690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LPB137_07695	COG0309	Hydrogenase expression formation protein (HypE)
LPB137_07700	COG0409	Hydrogenase expression formation protein
LPB137_07705	COG0298	carbon dioxide binding
LPB137_07710	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LPB137_07755	COG5002	protein histidine kinase activity
LPB137_07760	COG0745	RESPONSE REGULATOR receiver
LPB137_07785	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LPB137_07805	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LPB137_07810	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LPB137_07815	COG3259	Nickel-dependent hydrogenase
LPB137_07820	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LPB137_07835	COG0840	transmembrane signaling receptor activity
LPB137_07840	COG0840	transmembrane signaling receptor activity
LPB137_07845	COG4206	TonB-dependent receptor
LPB137_07860	COG4771	TonB-dependent receptor
LPB137_07875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LPB137_07895	COG0667	Aldo Keto reductase
LPB137_07900	COG1309	transcriptional regulator
LPB137_07940	COG1797	cobyrinic acid a,c-diamide synthase activity
LPB137_07955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LPB137_07960	COG4206	TonB-dependent receptor
LPB137_07980	COG0546	phosphoglycolate phosphatase activity
LPB137_07995	COG0848	biopolymer transport protein
LPB137_08000	COG0811	peptide transport
LPB137_08010	COG0330	HflC and HflK could
LPB137_08020	COG0745	RESPONSE REGULATOR receiver
LPB137_08025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LPB137_08030	COG0788	formyltetrahydrofolate deformylase activity
LPB137_08035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LPB137_08050	COG0395	ABC-type sugar transport system, permease component
LPB137_08065	COG3842	ATPase activity
LPB137_08070	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LPB137_08080	COG2188	Transcriptional regulator
LPB137_08085	COG0280	phosphate acetyltransferase
LPB137_08085	COG0281	malic enzyme
LPB137_08100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LPB137_08130	COG0754	glutathionylspermidine amidase activity
LPB137_08140	COG1663	tetraacyldisaccharide 4'-kinase activity
LPB137_08145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LPB137_08150	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LPB137_08170	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LPB137_08190	COG2814	Major facilitator Superfamily
LPB137_08195	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LPB137_08205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LPB137_08210	COG0805	protein transport
LPB137_08215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LPB137_08225	COG0733	neurotransmitter:sodium symporter activity
LPB137_08230	COG1278	Cold shock
LPB137_08245	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LPB137_08255	COG2949	membrane
LPB137_08260	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LPB137_08275	COG4991	sh3 domain protein
LPB137_08280	COG3850	Histidine kinase
LPB137_08280	COG4999	Histidine kinase
LPB137_08280	COG3437	response regulator, receiver
LPB137_08280	COG2205	protein histidine kinase activity
LPB137_08290	COG0659	secondary active sulfate transmembrane transporter activity
LPB137_08305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LPB137_08320	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
LPB137_08370	COG0419	ATPase involved in DNA repair
LPB137_08380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LPB137_08415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LPB137_08425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LPB137_08430	COG4589	Belongs to the CDS family
LPB137_08435	COG0204	Acyl-transferase
LPB137_08440	COG2267	carboxylic ester hydrolase activity
LPB137_08445	COG0671	phosphoesterase, PA-phosphatase related
LPB137_08445	COG2453	phosphatase
LPB137_08450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LPB137_08480	COG2199	diguanylate cyclase activity
LPB137_08495	COG0702	epimerase
LPB137_08515	COG0275	rRNA processing
LPB137_08525	COG0776	regulation of translation
LPB137_08530	COG1643	Atp-dependent helicase
LPB137_08535	COG1283	sodium-dependent phosphate transmembrane transporter activity
LPB137_08540	COG0513	Belongs to the DEAD box helicase family
LPB137_08570	COG2205	protein histidine kinase activity
LPB137_08575	COG0745	RESPONSE REGULATOR receiver
LPB137_08600	COG1132	(ABC) transporter
LPB137_08605	COG0840	transmembrane signaling receptor activity
LPB137_08610	COG0840	transmembrane signaling receptor activity
LPB137_08625	COG0653	protein targeting
LPB137_08630	COG4591	ABC-type transport system involved in lipoprotein release permease component
LPB137_08675	COG0484	heat shock protein binding
LPB137_08680	COG0789	Transcriptional regulator
LPB137_08685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LPB137_08690	COG0849	cell division
LPB137_08700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LPB137_08720	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
LPB137_08740	COG0768	penicillin binding
LPB137_08745	COG1338	Plays a role in the flagellum-specific transport system
LPB137_08765	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LPB137_08775	COG2200	EAL domain
LPB137_08775	COG2199	diguanylate cyclase activity
LPB137_08775	COG3287	FIST C domain
LPB137_08780	COG1047	Peptidyl-prolyl cis-trans
LPB137_08815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LPB137_08830	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LPB137_08835	COG0131	Imidazoleglycerol-phosphate dehydratase
LPB137_08840	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LPB137_08845	COG1388	LysM domain
LPB137_08845	COG0741	lytic transglycosylase activity
LPB137_08850	COG0084	hydrolase, TatD family'
LPB137_08860	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LPB137_08865	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LPB137_08870	COG0359	binds to the 23S rRNA
LPB137_08875	COG0642	Histidine kinase
LPB137_08890	COG0163	prenyltransferase activity
LPB137_08895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LPB137_08900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LPB137_08905	COG0124	histidyl-tRNA synthetase
LPB137_08910	COG1166	arginine decarboxylase activity
LPB137_08915	COG1045	serine acetyltransferase
LPB137_08925	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LPB137_08935	COG0753	catalase activity
LPB137_08940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LPB137_08950	COG3706	GGDEF domain
LPB137_08960	COG4536	flavin adenine dinucleotide binding
LPB137_08980	COG3422	double-strand break repair
LPB137_09005	COG0628	permease
LPB137_09025	COG2989	Protein conserved in bacteria
LPB137_09035	COG1028	Short-chain dehydrogenase reductase Sdr
LPB137_09065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPB137_09070	COG0564	pseudouridine synthase activity
LPB137_09075	COG0069	glutamate synthase activity
LPB137_09130	COG0848	biopolymer transport protein
LPB137_09135	COG0811	peptide transport
LPB137_09155	COG4771	TonB-dependent receptor
LPB137_09160	COG4771	TonB-dependent receptor
LPB137_09170	COG0513	Belongs to the DEAD box helicase family
LPB137_09200	COG0596	Alpha beta hydrolase
LPB137_09200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPB137_09200	COG2226	methyltransferase
LPB137_09225	COG2133	pyrroloquinoline quinone binding
LPB137_09235	COG1278	Cold shock
LPB137_09245	COG0697	spore germination
LPB137_09250	COG1773	rubredoxin
LPB137_09255	COG1187	pseudouridine synthase activity
LPB137_09280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LPB137_09280	COG0519	Catalyzes the synthesis of GMP from XMP
LPB137_09285	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LPB137_09290	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LPB137_09305	COG0436	Aminotransferase
LPB137_09310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LPB137_09315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPB137_09320	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LPB137_09350	COG3706	GGDEF domain
LPB137_09360	COG0300	oxidoreductase activity
LPB137_09370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LPB137_09375	COG0742	ribosomal rna small subunit methyltransferase
LPB137_09380	COG1418	mRNA catabolic process
LPB137_09390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPB137_09395	COG0552	protein localization to endoplasmic reticulum
LPB137_09425	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LPB137_09435	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LPB137_09450	COG1592	Rubrerythrin
LPB137_09455	COG1592	Rubrerythrin
LPB137_09465	COG0728	peptidoglycan biosynthetic process
LPB137_09470	COG1132	(ABC) transporter
LPB137_09475	COG0167	dihydroorotate dehydrogenase activity
LPB137_09485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LPB137_09490	COG1028	Short-chain dehydrogenase reductase Sdr
LPB137_09495	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LPB137_09500	COG0750	zinc metalloprotease
LPB137_09505	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LPB137_09515	COG1942	4-Oxalocrotonate Tautomerase
LPB137_09525	COG0134	indole-3-glycerol-phosphate synthase activity
LPB137_09535	COG0727	PFAM Uncharacterised protein family (UPF0153)
LPB137_09540	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LPB137_09550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LPB137_09550	COG0674	pyruvate-flavodoxin oxidoreductase activity
LPB137_09555	COG1013	pyruvate-flavodoxin oxidoreductase activity
LPB137_09565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPB137_09570	COG2176	DNA-directed DNA polymerase activity
LPB137_09575	COG0135	phosphoribosylanthranilate isomerase activity
LPB137_09580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LPB137_09605	COG0745	RESPONSE REGULATOR receiver
LPB137_09610	COG1666	GTP binding
LPB137_09615	COG5002	protein histidine kinase activity
LPB137_09620	COG2233	PERMEase
LPB137_09625	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LPB137_09640	COG2363	Small membrane protein
LPB137_09650	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LPB137_09655	COG2252	PERMEase
LPB137_09670	COG2151	metal-sulfur cluster biosynthetic enzyme
LPB137_09675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LPB137_09710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPB137_09715	COG3769	mannosylglycerate metabolic process
LPB137_09720	COG2379	hydroxypyruvate reductase
LPB137_09725	COG1215	transferase activity, transferring glycosyl groups
LPB137_09745	COG0519	Catalyzes the synthesis of GMP from XMP
LPB137_09770	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LPB137_09780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LPB137_09795	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LPB137_09805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LPB137_09810	COG0438	transferase activity, transferring glycosyl groups
LPB137_09815	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LPB137_09825	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LPB137_09825	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LPB137_09830	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LPB137_09845	COG1696	Membrane protein involved in D-alanine export
LPB137_09890	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LPB137_09895	COG0438	transferase activity, transferring glycosyl groups
LPB137_09900	COG0438	transferase activity, transferring glycosyl groups
LPB137_09905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPB137_09910	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LPB137_09915	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LPB137_09915	COG0662	Cupin 2, conserved barrel domain protein
LPB137_09920	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LPB137_09940	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LPB137_09950	COG0493	'glutamate synthase
LPB137_09955	COG0070	glutamate synthase
LPB137_09955	COG0069	glutamate synthase activity
LPB137_09955	COG0067	glutamate synthase
LPB137_09985	COG0840	transmembrane signaling receptor activity
LPB137_09995	COG0745	RESPONSE REGULATOR receiver
LPB137_10035	COG5001	Diguanylate cyclase
LPB137_10035	COG3706	GGDEF domain
LPB137_10035	COG2203	Gaf domain
LPB137_10035	COG4251	negative regulation of phosphorylation
LPB137_10045	COG0697	spore germination
LPB137_10050	COG0745	RESPONSE REGULATOR receiver
LPB137_10115	COG3706	GGDEF domain
LPB137_10120	COG0284	orotidine-5'-phosphate decarboxylase activity
LPB137_10125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPB137_10130	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LPB137_10135	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LPB137_10150	COG0069	glutamate synthase activity
LPB137_10160	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LPB137_10175	COG1450	Type ii and iii secretion system protein
LPB137_10180	COG1739	Uncharacterized protein family UPF0029
LPB137_10230	COG0859	PFAM glycosyl transferase family 9
LPB137_10230	COG0457	Tetratricopeptide repeat
LPB137_10260	COG2226	methyltransferase
LPB137_10265	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LPB137_10275	COG0277	FAD linked oxidase domain protein
LPB137_10315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPB137_10330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPB137_10350	COG0166	Belongs to the GPI family
LPB137_10355	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LPB137_10380	COG0438	transferase activity, transferring glycosyl groups
LPB137_10410	COG0110	maltose O-acetyltransferase activity
LPB137_10415	COG0438	transferase activity, transferring glycosyl groups
LPB137_10455	COG0489	protein tyrosine kinase activity
LPB137_10455	COG3206	protein involved in exopolysaccharide biosynthesis
LPB137_10470	COG0745	RESPONSE REGULATOR receiver
LPB137_10475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LPB137_10480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LPB137_10485	COG1047	Peptidyl-prolyl cis-trans
LPB137_10500	COG0823	Involved in the tonB-independent uptake of proteins
LPB137_10510	COG0848	biopolymer transport protein
LPB137_10515	COG0811	peptide transport
LPB137_10520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LPB137_10525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LPB137_10530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LPB137_10535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LPB137_10540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LPB137_10545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LPB137_10555	COG1475	DNA binding
LPB137_10560	COG1192	Involved in chromosome partitioning
LPB137_10580	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LPB137_10585	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LPB137_10590	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LPB137_10595	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LPB137_10600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LPB137_10605	COG0251	oxidation-reduction process
LPB137_10610	COG0358	DNA primase activity
LPB137_10625	COG0571	ribonuclease III activity
LPB137_10630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LPB137_10635	COG0501	Belongs to the peptidase M48B family
LPB137_10650	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LPB137_10660	COG0706	membrane insertase activity
LPB137_10665	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LPB137_10675	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LPB137_10685	COG0542	response to heat
LPB137_10690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LPB137_10705	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPB137_10710	COG0179	Fumarylacetoacetate (FAA) hydrolase
LPB137_10720	COG2259	Doxx family
LPB137_10735	COG4191	Histidine kinase
LPB137_10740	COG0138	bifunctional purine biosynthesis protein purh
LPB137_10755	COG4263	nitrous-oxide reductase activity
LPB137_10770	COG0437	4 iron, 4 sulfur cluster binding
LPB137_10785	COG0348	domain, Protein
LPB137_10790	COG1131	(ABC) transporter
LPB137_10800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LPB137_10810	COG0741	lytic transglycosylase activity
LPB137_10810	COG1196	nuclear chromosome segregation
LPB137_10810	COG0739	heme binding
LPB137_10815	COG2239	Acts as a magnesium transporter
LPB137_10825	COG1459	type II secretion system
LPB137_10830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LPB137_10850	COG0606	chelatase, subunit chli
LPB137_10855	COG0531	amino acid
LPB137_10865	COG0242	peptide deformylase activity
LPB137_10870	COG0740	serine-type endopeptidase activity
LPB137_10875	COG0544	peptidyl-prolyl cis-trans isomerase activity
LPB137_10880	COG2304	oxidoreductase activity
LPB137_10885	COG2326	polyphosphate kinase activity
LPB137_10900	COG1773	rubredoxin
LPB137_10920	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LPB137_10970	COG0582	viral genome integration into host DNA
LPB137_11040	COG0716	FMN binding
LPB137_11055	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LPB137_11070	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LPB137_11075	COG0159	tryptophan synthase activity
LPB137_11080	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LPB137_11085	COG2255	four-way junction helicase activity
LPB137_11090	COG0628	permease
LPB137_11100	COG4628	conserved protein (DUF2132)
LPB137_11115	COG0745	RESPONSE REGULATOR receiver
LPB137_11120	COG5002	protein histidine kinase activity
LPB137_11120	COG3850	Histidine kinase
LPB137_11130	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LPB137_11140	COG0542	response to heat
LPB137_11145	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LPB137_11150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LPB137_11160	COG0318	PFAM AMP-dependent synthetase and ligase
LPB137_11165	COG2030	dehydratase
LPB137_11185	COG1970	mechanosensitive ion channel activity
LPB137_11190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LPB137_11195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPB137_11195	COG4191	Histidine kinase
LPB137_11210	COG0243	molybdopterin cofactor binding
LPB137_11225	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LPB137_11230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LPB137_11235	COG1157	protein secretion by the type III secretion system
LPB137_11245	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LPB137_11265	COG1677	Flagellar hook-basal body complex protein FliE
LPB137_11275	COG0455	bacterial-type flagellum organization
LPB137_11280	COG1419	protein localization to endoplasmic reticulum
LPB137_11295	COG3951	Flagellar rod assembly protein muramidase FlgJ
LPB137_11305	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LPB137_11310	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LPB137_11330	COG1749	Flagellar hook protein flgE
LPB137_11340	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LPB137_11355	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LPB137_11360	COG1766	The M ring may be actively involved in energy transduction
LPB137_11365	COG1815	bacterial-type flagellum-dependent cell motility
LPB137_11370	COG4786	Flagellar basal body rod
LPB137_11400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LPB137_11410	COG0228	four-way junction DNA binding
LPB137_11415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LPB137_11425	COG1519	Transferase
LPB137_11435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LPB137_11440	COG0752	glycyl-tRNA synthetase alpha subunit
LPB137_11445	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LPB137_11465	COG0840	transmembrane signaling receptor activity
LPB137_11465	COG0840	transmembrane signaling receptor activity
LPB137_11515	COG3258	Cytochrome c
LPB137_11540	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LPB137_11545	COG0497	DNA recombination
LPB137_11550	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LPB137_11555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LPB137_11560	COG0049	tRNA binding
LPB137_11565	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LPB137_11570	COG4895	conserved protein (DUF2196)
LPB137_11585	COG3852	Histidine kinase
LPB137_11600	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LPB137_11605	COG0085	RNA polymerase activity
LPB137_11610	COG0222	ribosome binding
LPB137_11615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LPB137_11620	COG0081	regulation of translation
LPB137_11625	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LPB137_11630	COG0250	Participates in transcription elongation, termination and antitermination
LPB137_11645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LPB137_11650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPB137_11675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LPB137_11680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPB137_11685	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LPB137_11690	COG0444	Belongs to the ABC transporter superfamily
LPB137_11695	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LPB137_11700	COG0174	glutamine synthetase
LPB137_11710	COG0745	RESPONSE REGULATOR receiver
LPB137_11710	COG3706	GGDEF domain
LPB137_11715	COG0314	molybdopterin synthase activity
LPB137_11725	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
LPB137_11730	COG1968	undecaprenyl-diphosphatase activity
LPB137_11740	COG0772	Belongs to the SEDS family
LPB137_11750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LPB137_11790	COG0512	Glutamine amidotransferase of anthranilate synthase
LPB137_11850	COG1091	dTDP-4-dehydrorhamnose reductase activity
LPB137_11880	COG0438	transferase activity, transferring glycosyl groups
LPB137_11880	COG1216	Glycosyl transferase, family 2
LPB137_11890	COG0438	transferase activity, transferring glycosyl groups
LPB137_11890	COG1216	Glycosyl transferase, family 2
LPB137_11915	COG1840	ABC-type Fe3 transport system, periplasmic component
LPB137_11925	COG3842	ATPase activity
LPB137_11930	COG3706	GGDEF domain
LPB137_11935	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LPB137_11940	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LPB137_11945	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPB137_11950	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPB137_11955	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPB137_11955	COG0649	NAD binding
LPB137_11960	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LPB137_11970	COG0372	Belongs to the citrate synthase family
LPB137_11980	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LPB137_11985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPB137_11990	COG0839	Belongs to the complex I subunit 6 family
LPB137_11995	COG0713	ATP synthesis coupled electron transport
LPB137_12000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LPB137_12010	COG1007	ATP synthesis coupled electron transport
LPB137_12020	COG1053	succinate dehydrogenase
LPB137_12025	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LPB137_12035	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LPB137_12050	COG5002	protein histidine kinase activity
LPB137_12055	COG1451	nucleotide metabolic process
LPB137_12085	COG2183	response to ionizing radiation
LPB137_12100	COG2885	chlorophyll binding
LPB137_12100	COG3047	cAMP biosynthetic process
LPB137_12105	COG0251	oxidation-reduction process
LPB137_12120	COG2095	MarC family integral membrane protein
LPB137_12160	COG0500	methyltransferase
LPB137_12165	COG0514	ATP-dependent DNA helicase (RecQ)
LPB137_12180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LPB137_12200	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LPB137_12220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LPB137_12225	COG2828	Protein conserved in bacteria
LPB137_12240	COG0181	hydroxymethylbilane synthase activity
LPB137_12250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LPB137_12255	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LPB137_12270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LPB137_12275	COG0450	alkyl hydroperoxide reductase
LPB137_12285	COG0105	UTP biosynthetic process
LPB137_12295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LPB137_12300	COG0416	fatty acid biosynthetic process
LPB137_12305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPB137_12310	COG1687	branched-chain amino acid
LPB137_12315	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LPB137_12340	COG0540	Belongs to the ATCase OTCase family
LPB137_12350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LPB137_12360	COG0469	pyruvate kinase activity
LPB137_12375	COG5002	protein histidine kinase activity
LPB137_12380	COG0745	RESPONSE REGULATOR receiver
LPB137_12385	COG0792	nuclease activity
LPB137_12400	COG0156	8-amino-7-oxononanoate synthase activity
LPB137_12410	COG0288	reversible hydration of carbon dioxide
LPB137_12420	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LPB137_12430	COG2121	Domain of unknown function (DUF374)
LPB137_12435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LPB137_12445	COG0195	Participates in both transcription termination and antitermination
LPB137_12450	COG0215	cysteine-tRNA ligase activity
LPB137_12455	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LPB137_12460	COG0629	single-stranded DNA binding
LPB137_12465	COG0360	Binds together with S18 to 16S ribosomal RNA
LPB137_12475	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
LPB137_12485	COG0557	exoribonuclease II activity
LPB137_12490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LPB137_12505	COG3706	GGDEF domain
LPB137_12510	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LPB137_12525	COG0436	Aminotransferase
LPB137_12540	COG0343	queuine tRNA-ribosyltransferase activity
LPB137_12545	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LPB137_12550	COG1393	Belongs to the ArsC family
LPB137_12555	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LPB137_12560	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LPB137_12565	COG0560	Phosphoserine phosphatase
LPB137_12575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LPB137_12580	COG0736	holo-[acyl-carrier-protein] synthase activity
LPB137_12585	COG0438	transferase activity, transferring glycosyl groups
LPB137_12590	COG0601	transmembrane transport
LPB137_12595	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LPB137_12600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LPB137_12620	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LPB137_12665	COG1706	bacterial-type flagellum-dependent cell motility
LPB137_12670	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LPB137_12675	COG0418	dihydroorotase activity
LPB137_12685	COG0004	ammonium transporteR
LPB137_12695	COG0004	ammonium transporteR
LPB137_12705	COG1116	anion transmembrane transporter activity
LPB137_12705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LPB137_12715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LPB137_12715	COG1116	anion transmembrane transporter activity
LPB137_12725	COG2223	nitrite transmembrane transporter activity
LPB137_12730	COG0515	serine threonine protein kinase
LPB137_12730	COG2815	serine threonine protein kinase
LPB137_12735	COG0243	molybdopterin cofactor binding
LPB137_12740	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LPB137_12745	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LPB137_12750	COG0243	molybdopterin cofactor binding
LPB137_12760	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LPB137_12770	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LPB137_12780	COG0804	urea catabolic process
LPB137_12785	COG0832	Belongs to the urease beta subunit family
LPB137_12785	COG0831	urea catabolic process
LPB137_12795	COG0829	nickel cation binding
LPB137_12825	COG4191	Histidine kinase
LPB137_12830	COG4166	transmembrane transport
LPB137_12835	COG0745	RESPONSE REGULATOR receiver
LPB137_12845	COG0243	molybdopterin cofactor binding
LPB137_12855	COG0745	RESPONSE REGULATOR receiver
LPB137_12860	COG2204	response regulator
LPB137_12865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LPB137_12875	COG0745	RESPONSE REGULATOR receiver
LPB137_12880	COG4191	Histidine kinase
LPB137_12885	COG2116	formate transmembrane transporter activity
LPB137_12890	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
LPB137_12895	COG2815	serine threonine protein kinase
LPB137_12895	COG0515	serine threonine protein kinase
LPB137_12905	COG4191	Histidine kinase
LPB137_12915	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LPB137_12925	COG2962	Rard protein
LPB137_12955	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LPB137_12965	COG0640	Transcriptional regulator
LPB137_12970	COG1346	cytolysis
LPB137_12975	COG1380	Effector of murein hydrolase LrgA
LPB137_12990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LPB137_13010	COG2274	protein secretion by the type I secretion system
LPB137_13055	COG0129	dihydroxy-acid dehydratase activity
LPB137_13065	COG0745	RESPONSE REGULATOR receiver
LPB137_13070	COG5002	protein histidine kinase activity
LPB137_13085	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LPB137_13090	COG1492	cobalamin metabolic process
LPB137_13095	COG1401	restriction endodeoxyribonuclease activity
LPB137_13095	COG1401	restriction endodeoxyribonuclease activity
LPB137_13125	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LPB137_13135	COG2095	MarC family integral membrane protein
LPB137_13140	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LPB137_13145	COG4232	protein-disulfide reductase activity
LPB137_13195	COG0443	Heat shock 70 kDa protein
LPB137_13200	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LPB137_13205	COG1420	regulation of RNA biosynthetic process
LPB137_13220	COG0745	RESPONSE REGULATOR receiver
LPB137_13225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPB137_13225	COG4191	Histidine kinase
LPB137_13230	COG0101	tRNA pseudouridine synthase activity
LPB137_13240	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LPB137_13245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LPB137_13250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LPB137_13255	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LPB137_13265	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LPB137_13270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LPB137_13290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LPB137_13295	COG0148	phosphopyruvate hydratase activity
LPB137_13310	COG0475	glutathione-regulated potassium exporter activity
LPB137_13310	COG0569	domain protein
LPB137_13315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LPB137_13330	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LPB137_13335	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
LPB137_13345	COG1007	ATP synthesis coupled electron transport
LPB137_13355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LPB137_13360	COG0713	ATP synthesis coupled electron transport
LPB137_13370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPB137_13375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LPB137_13380	COG1034	ATP synthesis coupled electron transport
LPB137_13395	COG0649	NAD binding
LPB137_13400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPB137_13405	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPB137_13410	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPB137_13415	COG1222	aaa ATPase
LPB137_13435	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LPB137_13440	COG1252	NADH dehydrogenase
LPB137_13485	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
LPB137_13485	COG2066	Belongs to the glutaminase family
LPB137_13490	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
LPB137_13490	COG2066	Belongs to the glutaminase family
LPB137_13515	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LPB137_13520	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPB137_13525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPB137_13530	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPB137_13535	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LPB137_13555	COG0445	tRNA wobble uridine modification
LPB137_13575	COG0784	Response regulator, receiver
LPB137_13575	COG2198	Histidine kinase
LPB137_13575	COG5002	protein histidine kinase activity
LPB137_13580	COG3706	GGDEF domain
LPB137_13590	COG0348	domain, Protein
LPB137_13595	COG0504	CTP synthase activity
LPB137_13600	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LPB137_13600	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LPB137_13615	COG0693	protein deglycase activity
LPB137_13630	COG0587	DNA-directed DNA polymerase activity
LPB137_13635	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LPB137_13660	COG0315	cyclic pyranopterin monophosphate synthase activity
LPB137_13665	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LPB137_13670	COG1024	Enoyl-CoA hydratase
LPB137_13690	COG0670	Belongs to the BI1 family
LPB137_13700	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LPB137_13705	COG0233	cytoplasmic translational termination
LPB137_13710	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LPB137_13720	COG2814	Major facilitator Superfamily
LPB137_13725	COG0840	transmembrane signaling receptor activity
LPB137_13730	COG3022	response to hydroperoxide
LPB137_13735	COG3012	SEC-C Motif Domain Protein
LPB137_13765	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LPB137_13770	COG1012	belongs to the aldehyde dehydrogenase family
LPB137_13780	COG1704	LemA family
LPB137_13800	COG0546	phosphoglycolate phosphatase activity
LPB137_13830	COG2897	thiosulfate sulfurtransferase activity
LPB137_13835	COG5001	Diguanylate cyclase
LPB137_13835	COG5002	protein histidine kinase activity
LPB137_13850	COG2022	thiamine diphosphate biosynthetic process
LPB137_13865	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LPB137_13910	COG2081	HI0933 family
LPB137_13925	COG1959	2 iron, 2 sulfur cluster binding
LPB137_13930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LPB137_13940	COG0175	sulfate reduction
LPB137_13945	COG0175	sulfate reduction
LPB137_13950	COG2895	sulfate adenylyltransferase (ATP) activity
LPB137_13970	COG2066	Belongs to the glutaminase family
LPB137_13975	COG2860	membrane
LPB137_13990	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group