locus-tag	class	description
c1A100	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
c1A102	COG0145	ligase activity
c1A105	COG0145	ligase activity
c1A18	COG1960	acyl-CoA dehydrogenase activity
c1A200	COG4647	ligase activity
c1A203	COG2067	long-chain fatty acid transport protein
c1A206	COG1607	acyl-coa hydrolase
c1A208	COG1250	3-hydroxyacyl-CoA dehydrogenase
c1A208	COG1024	Enoyl-CoA hydratase
c1A232	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
c1A234	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
c1A237	COG0616	signal peptide processing
c1A25	COG1561	YicC-like family, N-terminal region
c1A283	COG2076	Multidrug Resistance protein
c1A29	COG0515	serine threonine protein kinase
c1A39	COG0635	Involved in the biosynthesis of porphyrin-containing compound
c1A43	COG0220	tRNA (guanine-N7-)-methyltransferase activity
c1A46	COG2022	thiamine diphosphate biosynthetic process
c1A49	COG0582	viral genome integration into host DNA
c1A53	COG0583	DNA-binding transcription factor activity
c1A56	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
c1A56	COG0644	oxidoreductase
c1A57	COG0523	cobalamin synthesis protein
c1A58	COG1028	Short-chain dehydrogenase reductase Sdr
c1A74	COG3039	Transposase
c1A75	COG4585	Histidine kinase
c1A77	COG2197	response regulator
c1A95	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
c2A172	COG0183	Belongs to the thiolase family
c2A173	COG1250	3-hydroxyacyl-CoA dehydrogenase
c2A174	COG1024	Enoyl-CoA hydratase
c2A195	COG2814	Major facilitator Superfamily
c2A227	COG1484	DNA-dependent DNA replication
c2A309	COG1024	Enoyl-CoA hydratase
c2A313	COG1028	Short-chain dehydrogenase reductase Sdr
c2A314	COG1028	Short-chain dehydrogenase reductase Sdr
c2A315	COG3321	synthase
c2A315	COG1028	Short-chain dehydrogenase reductase Sdr
c2A315	COG0604	alcohol dehydrogenase
ebA1002	COG2204	response regulator
ebA1021	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ebA1022	COG2096	Adenosyltransferase
ebA1024	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ebA1026	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ebA1027	COG0521	Mo-molybdopterin cofactor biosynthetic process
ebA1030	COG3028	Belongs to the UPF0307 family
ebA1031	COG0312	modulator of DNA gyrase
ebA1032	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ebA1033	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ebA1037	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ebA1042	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ebA1044	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ebA1045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ebA1045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ebA1046	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ebA1050	COG0793	Belongs to the peptidase S41A family
ebA1052	COG0588	phosphoglycerate mutase activity
ebA1056	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ebA1060	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ebA1065	COG1040	competence protein
ebA1066	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ebA1067	COG2226	methyltransferase
ebA1073	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ebA1078	COG0303	'Molybdopterin
ebA1080	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ebA1086	COG5002	protein histidine kinase activity
ebA1086	COG3447	MASE1 domain protein
ebA1086	COG5001	Diguanylate cyclase
ebA1090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ebA1090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ebA1094	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ebA1097	COG0483	inositol monophosphate 1-phosphatase activity
ebA1099	COG3954	Phosphoribulokinase
ebA110	COG0009	L-threonylcarbamoyladenylate synthase
ebA1101	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ebA1102	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ebA1103	COG0126	phosphoglycerate kinase activity
ebA1105	COG0469	pyruvate kinase activity
ebA1112	COG1215	transferase activity, transferring glycosyl groups
ebA1121	COG2885	chlorophyll binding
ebA1125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ebA1138	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ebA1139	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ebA114	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ebA1140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ebA1141	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ebA1143	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ebA1146	COG0006	proline dipeptidase activity
ebA1148	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ebA1152	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ebA1153	COG0138	bifunctional purine biosynthesis protein purh
ebA1155	COG0151	Belongs to the GarS family
ebA1156	COG0408	coproporphyrinogen oxidase activity
ebA116	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ebA1162	COG2959	enzyme of heme biosynthesis
ebA1166	COG0181	hydroxymethylbilane synthase activity
ebA1167	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ebA1170	COG0165	Argininosuccinate lyase
ebA1175	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ebA1177	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ebA1179	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ebA118	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ebA1181	COG0642	Histidine kinase
ebA1182	COG0745	RESPONSE REGULATOR receiver
ebA1185	COG0459	protein refolding
ebA1191	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ebA1192	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ebA1194	COG2969	positive regulation of protein catabolic process
ebA1195	COG0625	glutathione transferase activity
ebA1196	COG2857	Cytochrome c1
ebA1197	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ebA1198	COG0723	plastoquinol--plastocyanin reductase activity
ebA1200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ebA1202	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ebA1203	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ebA1206	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ebA1211	COG0243	molybdopterin cofactor binding
ebA1213	COG2223	nitrite transmembrane transporter activity
ebA1216	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ebA1223	COG2165	general secretion pathway protein
ebA1225	COG1459	type II secretion system
ebA1246	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ebA1247	COG0557	exoribonuclease II activity
ebA1249	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ebA125	COG4566	intracellular signal transduction
ebA1250	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ebA1252	COG0330	HflC and HflK could
ebA1253	COG0330	HflC and HflK could
ebA1254	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ebA1255	COG1923	regulation of RNA biosynthetic process
ebA1256	COG1160	GTP binding
ebA1258	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ebA1259	COG2976	Protein conserved in bacteria
ebA1260	COG0124	histidyl-tRNA synthetase
ebA1261	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ebA1268	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ebA1271	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ebA1272	COG0045	succinate-CoA ligase (ADP-forming) activity
ebA1284	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ebA1285	COG0805	protein transport
ebA1290	COG0140	phosphoribosyl-ATP diphosphatase activity
ebA1291	COG0107	imidazoleglycerol-phosphate synthase activity
ebA1293	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ebA1295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ebA1296	COG0131	Imidazoleglycerol-phosphate dehydratase
ebA1297	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ebA1299	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ebA1300	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ebA1302	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ebA1304	COG0842	Transport permease protein
ebA1306	COG1131	(ABC) transporter
ebA1310	COG2853	Lipoprotein
ebA1311	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ebA1312	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ebA1313	COG1127	ABC transporter
ebA1316	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ebA1320	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ebA1321	COG1024	Enoyl-CoA hydratase
ebA1327	COG0204	Acyl-transferase
ebA1328	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ebA133	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ebA1330	COG0751	glycine-tRNA ligase activity
ebA1331	COG0752	glycyl-tRNA synthetase alpha subunit
ebA1334	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ebA1335	COG4535	Mg2 and Co2 transporter CorC
ebA1336	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ebA1337	COG1702	phosphate starvation-inducible protein PhoH
ebA1339	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ebA135	COG0508	dehydrogenase complex catalyzes the overall conversion of
ebA1353	COG1484	DNA-dependent DNA replication
ebA136	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ebA1360	COG0582	viral genome integration into host DNA
ebA1378	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ebA1383	COG0477	Major facilitator Superfamily
ebA1387	COG2177	Part of the ABC transporter FtsEX involved in
ebA1390	COG2884	Cell division ATP-binding protein ftsE
ebA1394	COG0612	Peptidase, M16
ebA1396	COG0742	ribosomal rna small subunit methyltransferase
ebA1397	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ebA1400	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ebA1401	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ebA1404	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ebA1405	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ebA1406	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ebA1409	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ebA1411	COG0193	aminoacyl-tRNA hydrolase activity
ebA1413	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ebA1415	COG0343	queuine tRNA-ribosyltransferase activity
ebA1418	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ebA1421	COG2967	ApaG domain
ebA1430	COG0582	viral genome integration into host DNA
ebA1431	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ebA1433	COG0653	protein targeting
ebA1436	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ebA1442	COG1181	Belongs to the D-alanine--D-alanine ligase family
ebA1443	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ebA1444	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ebA1445	COG0772	Belongs to the SEDS family
ebA1447	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ebA1448	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ebA1449	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ebA145	COG2135	peptidase activity
ebA1450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ebA1452	COG0275	rRNA processing
ebA1456	COG0418	dihydroorotase activity
ebA1463	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ebA1464	COG2823	Periplasmic or secreted lipoprotein
ebA1466	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ebA1468	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ebA1471	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ebA1472	COG0511	ligase activity, forming carbon-carbon bonds
ebA1474	COG0439	Biotin carboxylase
ebA1475	COG2264	protein methyltransferase activity
ebA148	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ebA1488	COG0537	adenosine 5'-monophosphoramidase activity
ebA151	COG0028	Belongs to the TPP enzyme family
ebA1516	COG0438	transferase activity, transferring glycosyl groups
ebA1518	COG1088	dTDP-glucose 4,6-dehydratase activity
ebA1519	COG2755	lipolytic protein G-D-S-L family
ebA1519	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ebA152	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ebA1520	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ebA1527	COG0438	transferase activity, transferring glycosyl groups
ebA1531	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ebA1532	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ebA1535	COG0438	transferase activity, transferring glycosyl groups
ebA1543	COG4115	mRNA cleavage
ebA1544	COG4372	Transposase
ebA156	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ebA1602	COG1450	Type ii and iii secretion system protein
ebA1619	COG1459	type II secretion system
ebA1622	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ebA1627	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ebA1631	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ebA1642	COG1538	Outer membrane efflux protein
ebA1645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ebA165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ebA166	COG2176	DNA-directed DNA polymerase activity
ebA166	COG5002	protein histidine kinase activity
ebA1670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ebA1673	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ebA1679	COG1538	Outer membrane efflux protein
ebA168	COG0745	RESPONSE REGULATOR receiver
ebA1682	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ebA1688	COG0515	serine threonine protein kinase
ebA1688	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ebA169	COG5002	protein histidine kinase activity
ebA1702	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ebA1709	COG2119	membrane
ebA1711	COG0351	phosphomethylpyrimidine kinase
ebA1712	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ebA172	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ebA1726	COG1968	undecaprenyl-diphosphatase activity
ebA1728	COG3150	esterase
ebA1729	COG2226	methyltransferase
ebA1734	COG0557	exoribonuclease II activity
ebA1735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ebA1739	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ebA1741	COG2239	Acts as a magnesium transporter
ebA1743	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ebA1745	COG0351	phosphomethylpyrimidine kinase
ebA1750	COG0840	transmembrane signaling receptor activity
ebA1751	COG0643	Histidine kinase
ebA1751	COG2198	Histidine kinase
ebA1753	COG1678	Uncharacterized ACR, COG1678
ebA1756	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ebA1757	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ebA1759	COG0540	Belongs to the ATCase OTCase family
ebA1760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ebA1762	COG1872	DUF167
ebA1764	COG0762	integral membrane protein
ebA1782	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ebA1782	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ebA1787	COG2200	EAL domain
ebA179	COG3256	nitric oxide reductase
ebA1803	COG4566	intracellular signal transduction
ebA1805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ebA1807	COG2274	protein secretion by the type I secretion system
ebA1809	COG0735	belongs to the Fur family
ebA1812	COG1121	(ABC) transporter
ebA1814	COG0803	Belongs to the bacterial solute-binding protein 9 family
ebA1815	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ebA1817	COG0730	response to heat
ebA1822	COG0129	dihydroxy-acid dehydratase activity
ebA1823	COG3132	Protein of unknown function, DUF480
ebA1825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ebA1846	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ebA1848	COG0577	efflux transmembrane transporter activity
ebA1848	COG1136	(ABC) transporter
ebA1866	COG0672	)-iron permease
ebA1871	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ebA1874	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ebA1875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ebA1881	COG0433	COG0433 Predicted ATPase
ebA189	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ebA1942	COG4974	Belongs to the 'phage' integrase family
ebA1943	COG0517	IMP dehydrogenase activity
ebA1946	COG4974	Belongs to the 'phage' integrase family
ebA1953	COG1960	acyl-CoA dehydrogenase activity
ebA1954	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ebA1957	COG1846	Transcriptional regulator
ebA1959	COG1960	acyl-CoA dehydrogenase activity
ebA1960	COG0318	PFAM AMP-dependent synthetase and ligase
ebA1961	COG1024	Enoyl-CoA hydratase
ebA1965	COG5001	Diguanylate cyclase
ebA1971	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ebA1972	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ebA1973	COG1538	Outer membrane efflux protein
ebA1978	COG0783	Belongs to the Dps family
ebA1979	COG0443	Heat shock 70 kDa protein
ebA1980	COG0443	Heat shock 70 kDa protein
ebA1985	COG1960	acyl-CoA dehydrogenase activity
ebA1986	COG0492	ferredoxin-NADP+ reductase activity
ebA199	COG1484	DNA-dependent DNA replication
ebA2009	COG1484	DNA-dependent DNA replication
ebA2016	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ebA2022	COG2816	NAD+ diphosphatase activity
ebA2023	COG2205	protein histidine kinase activity
ebA2026	COG2909	trisaccharide binding
ebA2038	COG1250	3-hydroxyacyl-CoA dehydrogenase
ebA2038	COG1024	Enoyl-CoA hydratase
ebA204	COG4584	PFAM Integrase catalytic
ebA2046	COG1309	transcriptional regulator
ebA2047	COG1802	Transcriptional regulator
ebA2055	COG1960	acyl-CoA dehydrogenase activity
ebA2066	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ebA208	COG1484	DNA-dependent DNA replication
ebA2087	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ebA2089	COG3608	succinylglutamate desuccinylase aspartoacylase
ebA2089	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ebA2099	COG1902	pentaerythritol trinitrate reductase activity
ebA2099	COG0446	pyridine nucleotide-disulphide oxidoreductase
ebA2102	COG0753	catalase activity
ebA2110	COG2193	ferroxidase activity
ebA2111	COG3842	ATPase activity
ebA2113	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ebA2123	COG1484	DNA-dependent DNA replication
ebA2136	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ebA2148	COG2201	protein-glutamate methylesterase activity
ebA2152	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ebA2168	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ebA2176	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ebA2183	COG2770	Histidine kinase
ebA2183	COG3437	response regulator, receiver
ebA2186	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ebA2191	COG1024	Enoyl-CoA hydratase
ebA220	COG0582	viral genome integration into host DNA
ebA2208	COG2853	Lipoprotein
ebA222	COG0589	response to stress
ebA2222	COG1138	Cytochrome C-type biogenesis protein
ebA2229	COG1132	(ABC) transporter
ebA2233	COG0641	radical SAM
ebA2242	COG1012	belongs to the aldehyde dehydrogenase family
ebA2244	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ebA2245	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ebA2248	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ebA2252	COG0069	glutamate synthase activity
ebA2252	COG0067	glutamate synthase
ebA2252	COG0070	glutamate synthase
ebA2254	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ebA2256	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ebA2258	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ebA2278	COG1088	dTDP-glucose 4,6-dehydratase activity
ebA2286	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ebA2293	COG0284	orotidine-5'-phosphate decarboxylase activity
ebA2294	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ebA2295	COG3161	chorismate lyase activity
ebA2297	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ebA2303	COG0655	NAD(P)H dehydrogenase (quinone) activity
ebA2304	COG1741	Belongs to the pirin family
ebA2313	COG1024	Enoyl-CoA hydratase
ebA2314	COG0183	Belongs to the thiolase family
ebA2315	COG1024	Enoyl-CoA hydratase
ebA2315	COG1250	3-hydroxyacyl-CoA dehydrogenase
ebA232	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ebA234	COG0710	3-dehydroquinate dehydratase activity
ebA2402	COG2003	Belongs to the UPF0758 family
ebA2413	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ebA2416	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ebA2443	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ebA2469	COG1192	Involved in chromosome partitioning
ebA2481	COG0582	viral genome integration into host DNA
ebA2484	COG1484	DNA-dependent DNA replication
ebA2486	COG0582	viral genome integration into host DNA
ebA2514	COG2003	Belongs to the UPF0758 family
ebA2533	COG0488	(ABC) transporter
ebA2535	COG0675	Transposase, IS605 OrfB family
ebA2542	COG0697	spore germination
ebA2546	COG0189	ligase activity
ebA2575	COG4657	Part of a membrane complex involved in electron transport
ebA2576	COG2878	Part of a membrane complex involved in electron transport
ebA2578	COG4658	electron transport chain
ebA2586	COG2914	Belongs to the UPF0125 (RnfH) family
ebA2590	COG4325	translation initiation factor activity
ebA2596	COG4191	Histidine kinase
ebA2601	COG5265	(ABC) transporter
ebA2615	COG0583	DNA-binding transcription factor activity
ebA2617	COG0730	response to heat
ebA2623	COG0175	sulfate reduction
ebA2625	COG0175	sulfate reduction
ebA2628	COG2895	sulfate adenylyltransferase (ATP) activity
ebA2630	COG2070	2-Nitropropane dioxygenase
ebA2633	COG0330	HflC and HflK could
ebA2637	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ebA2638	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ebA2650	COG0823	Involved in the tonB-independent uptake of proteins
ebA2654	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ebA2656	COG0602	queuosine metabolic process
ebA2659	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ebA2666	COG1484	DNA-dependent DNA replication
ebA2677	COG4584	PFAM Integrase catalytic
ebA2677	COG2390	Transcriptional regulator
ebA2680	COG1484	DNA-dependent DNA replication
ebA2684	COG3756	Protein conserved in bacteria
ebA269	COG4584	PFAM Integrase catalytic
ebA2691	COG0582	viral genome integration into host DNA
ebA2699	COG1194	a g-specific adenine glycosylase
ebA270	COG1484	DNA-dependent DNA replication
ebA2710	COG0559	Belongs to the binding-protein-dependent transport system permease family
ebA2712	COG1970	mechanosensitive ion channel activity
ebA2713	COG2860	membrane
ebA2717	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ebA2719	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ebA2722	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ebA2723	COG1074	ATP-dependent DNA helicase activity
ebA2724	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ebA274	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ebA2741	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ebA2742	COG0569	domain protein
ebA2749	COG3383	formate dehydrogenase (NAD+) activity
ebA275	COG1205	dead DEAH box helicase
ebA275	COG1111	helicase
ebA2762	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ebA2792	COG0488	(ABC) transporter
ebA2794	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ebA2794	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ebA2795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ebA2804	COG0745	RESPONSE REGULATOR receiver
ebA2804	COG3706	GGDEF domain
ebA2806	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ebA2809	COG2813	Specifically methylates the guanine in position
ebA2809	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ebA2813	COG2814	Major facilitator Superfamily
ebA2817	COG0288	reversible hydration of carbon dioxide
ebA2819	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ebA2822	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ebA2825	COG0569	domain protein
ebA2828	COG2204	response regulator
ebA2830	COG5000	phosphorelay sensor kinase activity
ebA284	COG0210	DNA helicase
ebA2841	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ebA2842	COG0706	membrane insertase activity
ebA2846	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ebA2847	COG0592	DNA-directed DNA polymerase activity
ebA2851	COG1944	ATP diphosphatase activity
ebA2865	COG1278	Cold shock
ebA2867	COG0110	maltose O-acetyltransferase activity
ebA2869	COG0405	Gamma-glutamyltransferase
ebA2875	COG0393	Putative heavy-metal-binding
ebA2876	COG0488	(ABC) transporter
ebA2878	COG1959	2 iron, 2 sulfur cluster binding
ebA2880	COG3278	Belongs to the heme-copper respiratory oxidase family
ebA2889	COG3108	Peptidase M15
ebA2890	COG2989	Protein conserved in bacteria
ebA2907	COG1475	DNA binding
ebA2912	COG1192	Involved in chromosome partitioning
ebA2913	COG0357	Ribosomal RNA small subunit methyltransferase G
ebA2915	COG0445	tRNA wobble uridine modification
ebA293	COG1484	DNA-dependent DNA replication
ebA2935	COG0437	4 iron, 4 sulfur cluster binding
ebA2936	COG0243	molybdopterin cofactor binding
ebA2936	COG3383	formate dehydrogenase (NAD+) activity
ebA2944	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ebA2945	COG0746	molybdenum cofactor guanylyltransferase activity
ebA2950	COG1763	Mo-molybdopterin cofactor biosynthetic process
ebA2953	COG0501	Belongs to the peptidase M48B family
ebA2954	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ebA2958	COG1652	LysM domain
ebA2961	COG0758	DNA mediated transformation
ebA2962	COG2922	Belongs to the Smg family
ebA2969	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ebA2970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ebA2973	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ebA2976	COG1187	pseudouridine synthase activity
ebA298	COG0517	IMP dehydrogenase activity
ebA2982	COG2974	May be involved in recombination
ebA2986	COG0784	Response regulator, receiver
ebA2987	COG4251	negative regulation of phosphorylation
ebA2992	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ebA2993	COG1960	acyl-CoA dehydrogenase activity
ebA2995	COG0583	DNA-binding transcription factor activity
ebA2999	COG0356	it plays a direct role in the translocation of protons across the membrane
ebA3002	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ebA3003	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ebA3004	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ebA3006	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ebA3007	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ebA3008	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ebA3016	COG2226	methyltransferase
ebA3019	COG0745	RESPONSE REGULATOR receiver
ebA3026	COG0121	glutamine amidotransferase
ebA3029	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ebA303	COG0604	alcohol dehydrogenase
ebA3030	COG0154	amidase activity
ebA3033	COG1077	Cell shape determining protein MreB Mrl
ebA3040	COG0768	penicillin binding
ebA3041	COG0772	Belongs to the SEDS family
ebA3044	COG1686	Belongs to the peptidase S11 family
ebA3048	COG0321	lipoyl(octanoyl) transferase activity
ebA3050	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ebA306	COG0183	Belongs to the thiolase family
ebA3060	COG4566	intracellular signal transduction
ebA3067	COG3245	cytochrome
ebA3069	COG1652	LysM domain
ebA3077	COG0587	DNA-directed DNA polymerase activity
ebA3079	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ebA3086	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ebA3087	COG2258	MOSC domain
ebA3091	COG2733	membrane
ebA3111	COG0420	3'-5' exonuclease activity
ebA3118	COG1063	alcohol dehydrogenase
ebA3120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ebA3134	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ebA3143	COG0574	Belongs to the PEP-utilizing enzyme family
ebA3143	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ebA3149	COG0674	pyruvate-flavodoxin oxidoreductase activity
ebA3149	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ebA3150	COG1013	pyruvate-flavodoxin oxidoreductase activity
ebA3151	COG0004	ammonium transporteR
ebA3157	COG0606	chelatase, subunit chli
ebA3158	COG2814	Major facilitator Superfamily
ebA316	COG0439	Biotin carboxylase
ebA3180	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ebA3186	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ebA3192	COG1477	protein flavinylation
ebA321	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ebA3214	COG4372	Transposase
ebA3224	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ebA3236	COG3876	Protein conserved in bacteria
ebA3244	COG4772	TonB-dependent receptor
ebA3250	COG0861	Integral membrane protein TerC family
ebA3251	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ebA3283	COG1518	maintenance of DNA repeat elements
ebA3316	COG1368	sulfuric ester hydrolase activity
ebA3320	COG0642	Histidine kinase
ebA3323	COG0708	Exodeoxyribonuclease III
ebA3324	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ebA3328	COG0243	molybdopterin cofactor binding
ebA3338	COG1484	DNA-dependent DNA replication
ebA3365	COG0037	tRNA processing
ebA3377	COG0625	glutathione transferase activity
ebA3379	COG0617	tRNA 3'-terminal CCA addition
ebA3386	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ebA3389	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ebA3390	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ebA3393	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ebA3396	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ebA3399	COG1546	Belongs to the CinA family
ebA3402	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ebA3404	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ebA3410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ebA3433	COG0318	PFAM AMP-dependent synthetase and ligase
ebA3445	COG1538	Outer membrane efflux protein
ebA3446	COG1566	PFAM secretion protein HlyD family protein
ebA3463	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ebA3467	COG0788	formyltetrahydrofolate deformylase activity
ebA3469	COG0443	Heat shock 70 kDa protein
ebA3470	COG1278	Cold shock
ebA3478	COG1305	Transglutaminase-like
ebA3480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ebA3483	COG3045	CreA protein
ebA3490	COG0484	heat shock protein binding
ebA3494	COG0194	GDP metabolic process
ebA3495	COG1758	RNA polymerase activity
ebA3497	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ebA3500	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ebA3500	COG1199	ATP-dependent helicase activity
ebA3507	COG3850	Histidine kinase
ebA3508	COG2197	response regulator
ebA3514	COG4133	protoheme IX ABC transporter activity
ebA3522	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ebA3525	COG3088	subunit of a heme lyase
ebA3534	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ebA3535	COG1368	sulfuric ester hydrolase activity
ebA3542	COG1024	Enoyl-CoA hydratase
ebA3543	COG1250	3-hydroxyacyl-CoA dehydrogenase
ebA3544	COG2050	protein possibly involved in aromatic compounds catabolism
ebA3547	COG3396	Phenylacetate-CoA oxygenase
ebA3548	COG3460	Phenylacetate-CoA oxygenase
ebA3550	COG3396	Phenylacetate-CoA oxygenase
ebA3551	COG2151	metal-sulfur cluster biosynthetic enzyme
ebA3553	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ebA3559	COG0411	ABC transporter
ebA3561	COG1902	pentaerythritol trinitrate reductase activity
ebA3563	COG0513	Belongs to the DEAD box helicase family
ebA3564	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ebA3566	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ebA3571	COG4232	protein-disulfide reductase activity
ebA3572	COG1324	tolerance protein
ebA3574	COG0589	response to stress
ebA3576	COG0861	Integral membrane protein TerC family
ebA3583	COG0625	glutathione transferase activity
ebA3601	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ebA3606	COG0252	asparaginase activity
ebA3608	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ebA3609	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ebA3613	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ebA3614	COG0018	arginyl-trna synthetase
ebA3619	COG2902	Dehydrogenase
ebA3621	COG3158	transport of potassium into the cell
ebA3623	COG0686	Belongs to the AlaDH PNT family
ebA3624	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ebA3628	COG3243	poly(R)-hydroxyalkanoic acid synthase
ebA3630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ebA3634	COG0789	Transcriptional regulator
ebA3637	COG0288	reversible hydration of carbon dioxide
ebA3639	COG0183	Belongs to the thiolase family
ebA3640	COG1960	acyl-CoA dehydrogenase activity
ebA3642	COG1024	Enoyl-CoA hydratase
ebA3650	COG1660	Displays ATPase and GTPase activities
ebA3654	COG0604	alcohol dehydrogenase
ebA3657	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ebA3662	COG2204	response regulator
ebA3666	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ebA3674	COG0217	transcriptional regulatory protein
ebA3678	COG1555	photosystem II stabilization
ebA3678	COG1596	polysaccharide export
ebA3682	COG0513	Belongs to the DEAD box helicase family
ebA3688	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ebA3690	COG1492	cobalamin metabolic process
ebA3691	COG1024	Enoyl-CoA hydratase
ebA3695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ebA37	COG2204	response regulator
ebA3713	COG4964	Belongs to the GSP D family
ebA3727	COG2197	response regulator
ebA3735	COG0114	fumarate hydratase activity
ebA3736	COG1802	Transcriptional regulator
ebA3738	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ebA3738	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ebA3742	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ebA3743	COG0439	Biotin carboxylase
ebA3747	COG2321	neutral zinc metallopeptidase
ebA3750	COG2207	Transcriptional regulator
ebA3751	COG2807	transmembrane transport
ebA3761	COG4191	Histidine kinase
ebA3761	COG0784	Response regulator, receiver
ebA3766	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ebA3766	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ebA3766	COG1703	isobutyryl-CoA mutase activity
ebA3772	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
ebA3777	COG4584	PFAM Integrase catalytic
ebA3781	COG1484	DNA-dependent DNA replication
ebA3787	COG0586	Pfam SNARE associated Golgi protein
ebA3792	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ebA3794	COG0784	Response regulator, receiver
ebA3794	COG2198	Histidine kinase
ebA3794	COG2205	protein histidine kinase activity
ebA3801	COG2197	response regulator
ebA3803	COG0277	FAD linked oxidase domain protein
ebA3804	COG1522	sequence-specific DNA binding
ebA3808	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ebA381	COG1192	Involved in chromosome partitioning
ebA3810	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ebA3812	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ebA3814	COG0081	regulation of translation
ebA3816	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ebA3818	COG0085	RNA polymerase activity
ebA3819	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ebA3820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ebA3822	COG0049	tRNA binding
ebA3824	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ebA3826	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ebA3828	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ebA3829	COG0088	Forms part of the polypeptide exit tunnel
ebA3831	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ebA3832	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ebA3833	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ebA3834	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ebA3839	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ebA3841	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ebA3844	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ebA3846	COG0201	protein transport
ebA385	COG4372	Transposase
ebA3850	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ebA3852	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ebA3853	COG0202	RNA polymerase activity
ebA3856	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ebA3858	COG2814	Major facilitator Superfamily
ebA3859	COG0629	single-stranded DNA binding
ebA3862	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ebA3867	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ebA3876	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ebA3879	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ebA3882	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ebA3883	COG2084	Dehydrogenase
ebA3884	COG2084	Dehydrogenase
ebA3889	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ebA3890	COG0436	Aminotransferase
ebA3906	COG2814	Major facilitator Superfamily
ebA3924	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ebA3931	COG1032	radical SAM domain protein
ebA3939	COG4772	TonB-dependent receptor
ebA3942	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ebA3949	COG1560	Kdo2-lipid A biosynthetic process
ebA3950	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ebA3956	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ebA3958	COG2255	four-way junction helicase activity
ebA3959	COG0632	four-way junction helicase activity
ebA3964	COG1530	ribonuclease E activity
ebA3966	COG0424	maF-like protein
ebA3968	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ebA3971	COG0799	negative regulation of ribosome biogenesis
ebA3972	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ebA3979	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ebA3983	COG1115	amino acid carrier protein
ebA3984	COG2192	nodulation
ebA3985	COG1215	transferase activity, transferring glycosyl groups
ebA3985	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ebA3992	COG1132	(ABC) transporter
ebA3996	COG0438	transferase activity, transferring glycosyl groups
ebA3999	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ebA40	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ebA4005	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ebA4008	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ebA4019	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ebA4020	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ebA4025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ebA4025	COG1648	precorrin-2 dehydrogenase activity
ebA4027	COG1797	cobyrinic acid a,c-diamide synthase activity
ebA4029	COG0778	Nitroreductase
ebA4032	COG0583	DNA-binding transcription factor activity
ebA4033	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ebA4035	COG0668	transmembrane transport
ebA4038	COG0741	lytic transglycosylase activity
ebA4040	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ebA4043	COG0281	malic enzyme
ebA4043	COG0280	phosphate acetyltransferase
ebA4047	COG1686	Belongs to the peptidase S11 family
ebA4048	COG1414	Transcriptional regulator
ebA4050	COG0247	lactate metabolic process
ebA4051	COG1139	Iron-sulfur cluster binding protein
ebA4056	COG1187	pseudouridine synthase activity
ebA4058	COG0577	efflux transmembrane transporter activity
ebA4058	COG1136	(ABC) transporter
ebA4061	COG1136	(ABC) transporter
ebA4061	COG4591	ABC-type transport system involved in lipoprotein release permease component
ebA4065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ebA4066	COG0668	transmembrane transport
ebA4067	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ebA4074	COG1643	Atp-dependent helicase
ebA4075	COG0360	Binds together with S18 to 16S ribosomal RNA
ebA4078	COG0359	binds to the 23S rRNA
ebA4079	COG0305	Participates in initiation and elongation during chromosome replication
ebA4098	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ebA4099	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ebA4104	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ebA4105	COG0237	dephospho-CoA kinase activity
ebA4109	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
ebA4111	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ebA4117	COG3852	Histidine kinase
ebA4125	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ebA4126	COG3568	Endonuclease Exonuclease Phosphatase
ebA4131	COG1028	Short-chain dehydrogenase reductase Sdr
ebA4133	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ebA4139	COG0012	GTP binding
ebA4142	COG0583	DNA-binding transcription factor activity
ebA4143	COG0670	Belongs to the BI1 family
ebA4146	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ebA4147	COG1253	flavin adenine dinucleotide binding
ebA4148	COG0825	malonyl-CoA metabolic process
ebA4149	COG0037	tRNA processing
ebA4154	COG4566	intracellular signal transduction
ebA4164	COG2423	ornithine cyclodeaminase activity
ebA4167	COG5212	phosphodiesterase
ebA4169	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ebA4174	COG0546	phosphoglycolate phosphatase activity
ebA4186	COG3260	NADH ubiquinone oxidoreductase 20
ebA4187	COG0649	NAD binding
ebA4190	COG0651	ATP synthesis coupled electron transport
ebA4192	COG0650	Formate hydrogenlyase subunit 4
ebA4193	COG0651	ATP synthesis coupled electron transport
ebA4200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ebA4201	COG0134	indole-3-glycerol-phosphate synthase activity
ebA4211	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ebA4214	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ebA4224	COG0514	ATP-dependent DNA helicase (RecQ)
ebA4228	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ebA4229	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ebA4237	COG0109	protoheme IX farnesyltransferase activity
ebA4238	COG1999	signal sequence binding
ebA4241	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ebA4250	COG0489	protein tyrosine kinase activity
ebA4256	COG3267	Type II secretory pathway component ExeA
ebA4256	COG3409	Peptidoglycan-binding domain 1 protein
ebA426	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ebA4262	COG0438	transferase activity, transferring glycosyl groups
ebA4263	COG0367	asparagine synthase
ebA4264	COG0438	transferase activity, transferring glycosyl groups
ebA4265	COG0367	asparagine synthase
ebA4275	COG0438	transferase activity, transferring glycosyl groups
ebA4291	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ebA4294	COG2327	Polysaccharide pyruvyl transferase
ebA4297	COG0318	PFAM AMP-dependent synthetase and ligase
ebA4304	COG1216	Glycosyl transferase, family 2
ebA4327	COG1960	acyl-CoA dehydrogenase activity
ebA4330	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ebA4332	COG0071	Belongs to the small heat shock protein (HSP20) family
ebA4334	COG0494	nUDIX hydrolase
ebA4339	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ebA4348	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ebA4351	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ebA4362	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ebA4365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ebA4370	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ebA4371	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ebA4373	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ebA4376	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ebA4380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ebA4383	COG1466	dna polymerase III delta subunit
ebA4386	COG0495	leucyl-tRNA aminoacylation
ebA4390	COG0210	DNA helicase
ebA4391	COG1192	Involved in chromosome partitioning
ebA4392	COG0281	malic enzyme
ebA4392	COG0280	phosphate acetyltransferase
ebA4399	COG0450	alkyl hydroperoxide reductase
ebA4402	COG0659	secondary active sulfate transmembrane transporter activity
ebA4404	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ebA4404	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ebA4409	COG0489	protein tyrosine kinase activity
ebA4412	COG0717	Belongs to the dCTP deaminase family
ebA4413	COG1982	Orn Lys Arg decarboxylase major
ebA4415	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ebA4434	COG2030	dehydratase
ebA4438	COG1469	GTP cyclohydrolase I activity
ebA4439	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ebA4440	COG0142	geranyltranstransferase activity
ebA4444	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ebA4447	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ebA4448	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ebA4449	COG0196	riboflavin kinase activity
ebA4451	COG0860	N-Acetylmuramoyl-L-alanine amidase
ebA4453	COG0802	atpase or kinase
ebA4454	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ebA4456	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ebA4458	COG1028	Short-chain dehydrogenase reductase Sdr
ebA4462	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ebA4463	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ebA4468	COG0745	RESPONSE REGULATOR receiver
ebA4473	COG2224	Isocitrate lyase
ebA4476	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ebA4477	COG0542	response to heat
ebA4482	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ebA4490	COG0277	FAD linked oxidase domain protein
ebA4491	COG0277	FAD linked oxidase domain protein
ebA4492	COG0247	lactate metabolic process
ebA4496	COG0598	Magnesium transport protein CorA
ebA4497	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ebA4498	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ebA4500	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ebA4502	COG0513	Belongs to the DEAD box helicase family
ebA4504	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ebA4507	COG1653	transport
ebA4509	COG0584	glycerophosphoryl diester phosphodiesterase
ebA4512	COG0142	geranyltranstransferase activity
ebA4517	COG1595	DNA-templated transcription, initiation
ebA452	COG4372	Transposase
ebA4535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ebA4544	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ebA4558	COG4948	Mandelate Racemase Muconate Lactonizing
ebA4561	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ebA4562	COG0765	amino acid transport
ebA4564	COG0765	amino acid transport
ebA4567	COG1126	abc transporter atp-binding protein
ebA4568	COG0516	GMP reductase activity
ebA4568	COG0517	IMP dehydrogenase activity
ebA4576	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ebA4588	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ebA4588	COG0674	pyruvate-flavodoxin oxidoreductase activity
ebA4589	COG1013	pyruvate-flavodoxin oxidoreductase activity
ebA4598	COG0626	cystathionine gamma-synthase activity
ebA4609	COG0004	ammonium transporteR
ebA4612	COG0697	spore germination
ebA4614	COG3193	protein, possibly involved in utilization of glycolate and propanediol
ebA4617	COG3622	Belongs to the hyi family
ebA4623	COG1454	alcohol dehydrogenase
ebA4625	COG1012	belongs to the aldehyde dehydrogenase family
ebA4627	COG3284	Transcriptional regulator
ebA4638	COG1294	oxidase, subunit
ebA4639	COG1271	oxidase subunit
ebA4644	COG2059	Chromate
ebA4656	COG1960	acyl-CoA dehydrogenase activity
ebA4657	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ebA4661	COG0318	PFAM AMP-dependent synthetase and ligase
ebA4666	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ebA4668	COG0402	S-adenosylhomocysteine deaminase activity
ebA4676	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ebA4678	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ebA4700	COG0145	ligase activity
ebA4701	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
ebA4702	COG4647	ligase activity
ebA4717	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ebA4722	COG3284	Transcriptional regulator
ebA4725	COG0564	pseudouridine synthase activity
ebA4728	COG3243	poly(R)-hydroxyalkanoic acid synthase
ebA4729	COG1028	Short-chain dehydrogenase reductase Sdr
ebA473	COG2124	cytochrome p450
ebA4732	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
ebA4733	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ebA4736	COG1752	Esterase of the alpha-beta hydrolase superfamily
ebA4737	COG0277	FAD linked oxidase domain protein
ebA474	COG1943	Transposase
ebA4742	COG1250	3-hydroxyacyl-CoA dehydrogenase
ebA4743	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ebA4746	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ebA4749	COG0318	PFAM AMP-dependent synthetase and ligase
ebA4751	COG0028	Belongs to the TPP enzyme family
ebA4753	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ebA4754	COG2814	Major facilitator Superfamily
ebA4755	COG4783	chaperone-mediated protein folding
ebA4757	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ebA4758	COG0066	3-isopropylmalate dehydratase activity
ebA4760	COG0473	3-isopropylmalate dehydrogenase activity
ebA4761	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ebA4770	COG0101	tRNA pseudouridine synthase activity
ebA4775	COG0133	tryptophan synthase activity
ebA4776	COG0159	tryptophan synthase activity
ebA4777	COG0285	dihydrofolate synthase activity
ebA4778	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ebA478	COG0129	dihydroxy-acid dehydratase activity
ebA4786	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ebA4788	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ebA4792	COG0215	cysteine-tRNA ligase activity
ebA4793	COG0484	heat shock protein binding
ebA4794	COG0443	Heat shock 70 kDa protein
ebA4795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ebA4796	COG0515	serine threonine protein kinase
ebA4796	COG2815	serine threonine protein kinase
ebA4802	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ebA4803	COG1420	regulation of RNA biosynthetic process
ebA4805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ebA4808	COG0497	DNA recombination
ebA4812	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ebA4813	COG0505	Belongs to the CarA family
ebA4815	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ebA4816	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ebA4819	COG1534	Rna-binding protein
ebA4820	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ebA4823	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ebA4825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ebA4826	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ebA4828	COG0573	inorganic phosphate transmembrane transporter activity
ebA4829	COG0573	inorganic phosphate transmembrane transporter activity
ebA4830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ebA4831	COG0149	triose-phosphate isomerase activity
ebA4835	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ebA4836	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ebA4837	COG0649	NAD binding
ebA4838	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ebA4841	COG1034	ATP synthesis coupled electron transport
ebA4841	COG1034	ATP synthesis coupled electron transport
ebA4842	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ebA4843	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ebA4848	COG1007	ATP synthesis coupled electron transport
ebA485	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ebA4853	COG1230	cation diffusion facilitator family transporter
ebA486	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ebA4863	COG2951	lytic endotransglycosylase activity
ebA4865	COG0326	Molecular chaperone. Has ATPase activity
ebA4871	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ebA4877	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ebA4878	COG4660	Part of a membrane complex involved in electron transport
ebA4882	COG4658	electron transport chain
ebA4884	COG2878	Part of a membrane complex involved in electron transport
ebA4887	COG4657	Part of a membrane complex involved in electron transport
ebA4888	COG0167	dihydroorotate dehydrogenase activity
ebA4890	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ebA4891	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ebA4892	COG3842	ATPase activity
ebA4893	COG1178	ABC-type Fe3 transport system permease component
ebA4918	COG1840	ABC-type Fe3 transport system, periplasmic component
ebA492	COG4974	Belongs to the 'phage' integrase family
ebA4921	COG0791	NLP P60 protein
ebA493	COG0582	viral genome integration into host DNA
ebA494	COG4974	Belongs to the 'phage' integrase family
ebA4946	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ebA4948	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ebA495	COG4974	Belongs to the 'phage' integrase family
ebA4951	COG0436	Aminotransferase
ebA4962	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ebA4962	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ebA4963	COG2719	SpoVR family
ebA4964	COG2718	Belongs to the UPF0229 family
ebA4966	COG2766	serine protein kinase
ebA4969	COG0544	peptidyl-prolyl cis-trans isomerase activity
ebA497	COG4974	Belongs to the 'phage' integrase family
ebA4970	COG0740	serine-type endopeptidase activity
ebA4971	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ebA4973	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ebA4979	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ebA4984	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ebA499	COG4974	Belongs to the 'phage' integrase family
ebA50	COG2354	Protein conserved in bacteria
ebA5001	COG0798	PFAM Bile acid sodium symporter
ebA5005	COG2414	aldehyde ferredoxin oxidoreductase
ebA5007	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ebA5014	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ebA5018	COG0583	DNA-binding transcription factor activity
ebA5020	COG0702	epimerase
ebA5023	COG3038	cytochrome b561
ebA503	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ebA5035	COG2982	Protein involved in outer membrane biogenesis
ebA5055	COG2814	Major facilitator Superfamily
ebA5056	COG0583	DNA-binding transcription factor activity
ebA506	COG1819	glycosyl
ebA5068	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ebA5077	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ebA5078	COG1570	exodeoxyribonuclease VII activity
ebA5081	COG0811	peptide transport
ebA5085	COG1663	tetraacyldisaccharide 4'-kinase activity
ebA5086	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ebA5087	COG0563	adenylate kinase activity
ebA5095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ebA5096	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ebA5097	COG0137	argininosuccinate synthase activity
ebA5101	COG1666	GTP binding
ebA5117	COG3275	phosphorelay sensor kinase activity
ebA5123	COG0494	nUDIX hydrolase
ebA5128	COG2217	Heavy metal translocating P-type atpase
ebA5131	COG3278	Belongs to the heme-copper respiratory oxidase family
ebA5134	COG2010	Cytochrome c
ebA5139	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ebA5140	COG3243	poly(R)-hydroxyalkanoic acid synthase
ebA5141	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ebA5149	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ebA5151	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ebA5154	COG2217	Heavy metal translocating P-type atpase
ebA5160	COG0366	Alpha amylase catalytic
ebA5169	COG2409	Drug exporters of the RND superfamily
ebA5186	COG1132	(ABC) transporter
ebA5193	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ebA5199	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ebA5202	COG0183	Belongs to the thiolase family
ebA5205	COG0501	Belongs to the peptidase M48B family
ebA5206	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ebA5208	COG0166	Belongs to the GPI family
ebA5215	COG0254	rRNA binding
ebA5226	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ebA5230	COG4133	protoheme IX ABC transporter activity
ebA5242	COG1484	DNA-dependent DNA replication
ebA5251	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ebA5255	COG3318	Belongs to the UPF0149 family
ebA5255	COG3012	SEC-C Motif Domain Protein
ebA5263	COG3012	SEC-C Motif Domain Protein
ebA5264	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ebA527	COG2003	Belongs to the UPF0758 family
ebA5271	COG0367	asparagine synthase
ebA5272	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ebA5272	COG0189	ligase activity
ebA5273	COG1363	Peptidase, m42
ebA5278	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ebA529	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ebA5293	COG0587	DNA-directed DNA polymerase activity
ebA5298	COG1024	Enoyl-CoA hydratase
ebA5300	COG1028	Short-chain dehydrogenase reductase Sdr
ebA5307	COG0411	ABC transporter
ebA5311	COG2814	Major facilitator Superfamily
ebA5317	COG0318	PFAM AMP-dependent synthetase and ligase
ebA5318	COG1024	Enoyl-CoA hydratase
ebA5319	COG0183	Belongs to the thiolase family
ebA5321	COG1960	acyl-CoA dehydrogenase activity
ebA5341	COG1484	DNA-dependent DNA replication
ebA536	COG3384	dioxygenase
ebA5362	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ebA537	COG1959	2 iron, 2 sulfur cluster binding
ebA5375	COG2204	response regulator
ebA5381	COG1012	belongs to the aldehyde dehydrogenase family
ebA5390	COG3327	negative regulation of DNA-templated transcription, initiation
ebA5392	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ebA5393	COG0243	molybdopterin cofactor binding
ebA5393	COG0243	molybdopterin cofactor binding
ebA5406	COG0590	tRNA wobble adenosine to inosine editing
ebA5408	COG1376	ErfK ybiS ycfS ynhG family protein
ebA5414	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ebA5415	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ebA5421	COG0084	hydrolase, TatD family'
ebA5427	COG1473	amidohydrolase
ebA5428	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ebA5430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ebA5433	COG1067	ATP-dependent peptidase activity
ebA5438	COG0556	nucleotide-excision repair
ebA5440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ebA5441	COG1530	ribonuclease E activity
ebA5444	COG0546	phosphoglycolate phosphatase activity
ebA5450	COG0424	maF-like protein
ebA5452	COG1399	metal-binding, possibly nucleic acid-binding protein
ebA5454	COG0416	fatty acid biosynthetic process
ebA5455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ebA5461	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ebA5470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ebA5484	COG4695	Portal protein
ebA5492	COG4372	Transposase
ebA5498	COG1484	DNA-dependent DNA replication
ebA550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ebA551	COG0506	proline dehydrogenase activity
ebA551	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ebA551	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ebA5511	COG4584	PFAM Integrase catalytic
ebA5511	COG2390	Transcriptional regulator
ebA5514	COG1484	DNA-dependent DNA replication
ebA5523	COG4372	Transposase
ebA553	COG1320	monovalent cation:proton antiporter activity
ebA5534	COG0582	viral genome integration into host DNA
ebA5535	COG0481	GTPase activity
ebA5536	COG0681	Belongs to the peptidase S26 family
ebA5539	COG0571	ribonuclease III activity
ebA554	COG2212	antiporter activity
ebA5540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ebA5541	COG1381	Involved in DNA repair and RecF pathway recombination
ebA5544	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ebA5547	COG1472	Belongs to the glycosyl hydrolase 3 family
ebA5548	COG0322	excinuclease ABC activity
ebA555	COG1863	multisubunit Na H antiporter MnhE subunit
ebA5555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ebA5556	COG0569	domain protein
ebA556	COG0651	ATP synthesis coupled electron transport
ebA5576	COG0438	transferase activity, transferring glycosyl groups
ebA558	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ebA558	COG2111	Na H antiporter
ebA5610	COG0583	DNA-binding transcription factor activity
ebA5611	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ebA5611	COG0045	succinate-CoA ligase (ADP-forming) activity
ebA5611	COG1042	CoA-binding domain protein
ebA5612	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ebA5616	COG0179	Fumarylacetoacetate (FAA) hydrolase
ebA5619	COG1024	Enoyl-CoA hydratase
ebA5622	COG0243	molybdopterin cofactor binding
ebA563	COG1943	Transposase
ebA5630	COG0437	4 iron, 4 sulfur cluster binding
ebA5641	COG1960	acyl-CoA dehydrogenase activity
ebA5643	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ebA5649	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ebA5664	COG1802	Transcriptional regulator
ebA5667	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ebA5667	COG0045	succinate-CoA ligase (ADP-forming) activity
ebA5667	COG1042	CoA-binding domain protein
ebA5668	COG1960	acyl-CoA dehydrogenase activity
ebA5669	COG1960	acyl-CoA dehydrogenase activity
ebA5670	COG1028	Short-chain dehydrogenase reductase Sdr
ebA5678	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ebA5680	COG0163	prenyltransferase activity
ebA5686	COG0028	Belongs to the TPP enzyme family
ebA5708	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ebA5710	COG2814	Major facilitator Superfamily
ebA5712	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ebA5713	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ebA5715	COG4585	Histidine kinase
ebA5719	COG2197	response regulator
ebA5720	COG3396	Phenylacetate-CoA oxygenase
ebA5721	COG3460	Phenylacetate-CoA oxygenase
ebA5722	COG3396	Phenylacetate-CoA oxygenase
ebA5723	COG2151	metal-sulfur cluster biosynthetic enzyme
ebA5725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ebA5729	COG0183	Belongs to the thiolase family
ebA5732	COG1024	Enoyl-CoA hydratase
ebA5738	COG0513	Belongs to the DEAD box helicase family
ebA5739	COG0010	Belongs to the arginase family
ebA5740	COG1228	amidohydrolase
ebA5741	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ebA5742	COG2986	histidine ammonia-lyase
ebA5750	COG4585	Histidine kinase
ebA5752	COG2197	response regulator
ebA5760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ebA5773	COG0511	ligase activity, forming carbon-carbon bonds
ebA5774	COG0439	Biotin carboxylase
ebA5789	COG1028	Short-chain dehydrogenase reductase Sdr
ebA5790	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ebA5797	COG0183	Belongs to the thiolase family
ebA5802	COG1611	Belongs to the LOG family
ebA5807	COG1704	LemA family
ebA5811	COG3047	cAMP biosynthetic process
ebA5820	COG1136	(ABC) transporter
ebA5827	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ebA5829	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ebA583	COG0366	Alpha amylase catalytic
ebA5833	COG1028	Short-chain dehydrogenase reductase Sdr
ebA5836	COG1902	pentaerythritol trinitrate reductase activity
ebA5836	COG0446	pyridine nucleotide-disulphide oxidoreductase
ebA5838	COG0779	Required for maturation of 30S ribosomal subunits
ebA584	COG0837	glucose binding
ebA5840	COG2251	uridine kinase activity
ebA5840	COG0195	Participates in both transcription termination and antitermination
ebA5841	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ebA5842	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ebA5843	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ebA5844	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ebA5846	COG1185	polyribonucleotide nucleotidyltransferase activity
ebA5850	COG3657	addiction module killer protein
ebA5857	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ebA587	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ebA5870	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ebA5881	COG0438	transferase activity, transferring glycosyl groups
ebA5895	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ebA590	COG1597	lipid kinase activity
ebA5900	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ebA5901	COG1086	Polysaccharide biosynthesis protein
ebA5903	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ebA5917	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ebA5948	COG1484	DNA-dependent DNA replication
ebA595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ebA596	COG1448	Aminotransferase
ebA598	COG1368	sulfuric ester hydrolase activity
ebA5982	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ebA5984	COG0024	Methionine aminopeptidase
ebA5986	COG0052	Belongs to the universal ribosomal protein uS2 family
ebA5987	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ebA5988	COG0528	UMP kinase activity
ebA5990	COG0233	cytoplasmic translational termination
ebA5991	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ebA5992	COG0575	Belongs to the CDS family
ebA5994	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ebA5998	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ebA5999	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ebA600	COG0463	Glycosyl transferase, family 2
ebA6000	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ebA6002	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ebA6003	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ebA6008	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ebA6011	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ebA6013	COG2226	methyltransferase
ebA6017	COG2267	carboxylic ester hydrolase activity
ebA6018	COG0156	8-amino-7-oxononanoate synthase activity
ebA6021	COG3022	response to hydroperoxide
ebA6023	COG2866	Carboxypeptidase
ebA6034	COG0560	Phosphoserine phosphatase
ebA6035	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ebA6036	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ebA6047	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ebA6049	COG2900	Belongs to the SlyX family
ebA605	COG3033	Beta-eliminating lyase
ebA6051	COG0784	Response regulator, receiver
ebA6051	COG2205	protein histidine kinase activity
ebA6075	COG1028	Short-chain dehydrogenase reductase Sdr
ebA6077	COG2133	pyrroloquinoline quinone binding
ebA608	COG0671	phosphoesterase, PA-phosphatase related
ebA609	COG2217	Heavy metal translocating P-type atpase
ebA6092	COG1607	acyl-coa hydrolase
ebA6096	COG4772	TonB-dependent receptor
ebA6101	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ebA6102	COG0488	(ABC) transporter
ebA6104	COG5001	Diguanylate cyclase
ebA6111	COG0583	DNA-binding transcription factor activity
ebA6116	COG1215	transferase activity, transferring glycosyl groups
ebA6124	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ebA6124	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ebA6126	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ebA6127	COG0613	PHP domain protein
ebA6128	COG0009	L-threonylcarbamoyladenylate synthase
ebA6130	COG1994	Peptidase M50
ebA6131	COG0180	Tryptophanyl-tRNA synthetase
ebA6132	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ebA6134	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ebA6138	COG1196	nuclear chromosome segregation
ebA6138	COG0739	heme binding
ebA6138	COG0741	lytic transglycosylase activity
ebA6142	COG0047	phosphoribosylformylglycinamidine synthase activity
ebA6142	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ebA6156	COG0824	Thioesterase
ebA6159	COG0504	CTP synthase activity
ebA6160	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ebA6162	COG0148	phosphopyruvate hydratase activity
ebA6165	COG0791	NLP P60 protein
ebA6174	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ebA6176	COG0306	phosphate transporter
ebA6179	COG0302	gtp cyclohydrolase
ebA618	COG3258	Cytochrome c
ebA6183	COG4681	YaeQ
ebA6189	COG1253	flavin adenine dinucleotide binding
ebA6190	COG1012	belongs to the aldehyde dehydrogenase family
ebA6197	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ebA62	COG0242	peptide deformylase activity
ebA6204	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ebA6206	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ebA6207	COG4208	sulfate ABC transporter
ebA6208	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ebA621	COG2863	cytochrome
ebA6215	COG3300	MHYT domain
ebA6215	COG5001	Diguanylate cyclase
ebA6230	COG1131	(ABC) transporter
ebA6231	COG0842	Transport permease protein
ebA6232	COG0058	SHG alpha-glucan phosphorylase activity
ebA6233	COG0642	Histidine kinase
ebA6235	COG0745	RESPONSE REGULATOR receiver
ebA6240	COG4221	oxidoreductase activity
ebA6242	COG0318	PFAM AMP-dependent synthetase and ligase
ebA6247	COG1309	transcriptional regulator
ebA6248	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ebA6253	COG1136	(ABC) transporter
ebA6266	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ebA6272	COG4263	nitrous-oxide reductase activity
ebA6278	COG2197	response regulator
ebA6280	COG3850	Histidine kinase
ebA6282	COG2181	nitrate reductase activity
ebA6283	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ebA6285	COG1140	nitrate reductase beta subunit
ebA6286	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ebA6296	COG2081	HI0933 family
ebA6313	COG1671	Belongs to the UPF0178 family
ebA6316	COG0534	Mate efflux family protein
ebA633	COG1484	DNA-dependent DNA replication
ebA6332	COG3012	SEC-C Motif Domain Protein
ebA6347	COG1484	DNA-dependent DNA replication
ebA6357	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ebA6367	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ebA637	COG0527	aspartate kinase activity
ebA6371	COG1881	PFAM PEBP family protein
ebA6380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ebA6382	COG3115	cell septum assembly
ebA6384	COG1196	nuclear chromosome segregation
ebA6386	COG2171	N-acyltransferase activity
ebA6388	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ebA6392	COG0784	Response regulator, receiver
ebA6393	COG0386	Belongs to the glutathione peroxidase family
ebA6396	COG0443	Heat shock 70 kDa protein
ebA6397	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ebA64	COG1490	D-aminoacyl-tRNA deacylase activity
ebA6400	COG0822	iron-sulfur transferase activity
ebA6401	COG1104	cysteine desulfurase activity
ebA6402	COG1104	cysteine desulfurase activity
ebA6405	COG1045	serine acetyltransferase
ebA642	COG0720	synthase
ebA6422	COG0107	imidazoleglycerol-phosphate synthase activity
ebA6426	COG0243	molybdopterin cofactor binding
ebA6439	COG3852	Histidine kinase
ebA6441	COG2204	response regulator
ebA645	COG3264	Mechanosensitive ion channel
ebA645	COG1511	domain protein
ebA6453	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ebA6456	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ebA6458	COG0328	RNA-DNA hybrid ribonuclease activity
ebA6459	COG2226	methyltransferase
ebA6465	COG1388	LysM domain
ebA6465	COG0741	lytic transglycosylase activity
ebA6469	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ebA647	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ebA6478	COG2205	protein histidine kinase activity
ebA6482	COG0583	DNA-binding transcription factor activity
ebA6485	COG0477	Major facilitator Superfamily
ebA6487	COG1573	uracil-dna glycosylase
ebA6491	COG0456	acetyltransferase
ebA6494	COG1214	PFAM Peptidase M22, glycoprotease
ebA6497	COG0745	RESPONSE REGULATOR receiver
ebA6499	COG2350	Protein conserved in bacteria
ebA650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ebA650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ebA6501	COG2917	probably involved in intracellular septation
ebA6504	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ebA6506	COG1960	acyl-CoA dehydrogenase activity
ebA6513	COG1309	transcriptional regulator
ebA6514	COG0084	hydrolase, TatD family'
ebA6518	COG0318	PFAM AMP-dependent synthetase and ligase
ebA6523	COG1127	ABC transporter
ebA6524	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ebA6525	COG0248	Ppx GppA phosphatase
ebA6526	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ebA6528	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ebA6530	COG3228	Belongs to the MtfA family
ebA6539	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ebA6542	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ebA6543	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ebA6546	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ebA6549	COG1355	regulation of microtubule-based process
ebA655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ebA6551	COG3885	ferrous iron binding
ebA6551	COG2078	PFAM AMMECR1 domain protein
ebA6555	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ebA658	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ebA6583	COG0210	DNA helicase
ebA6589	COG1401	restriction endodeoxyribonuclease activity
ebA6594	COG0741	lytic transglycosylase activity
ebA661	COG0187	DNA topoisomerase II activity
ebA6644	COG0582	viral genome integration into host DNA
ebA6645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ebA6645	COG0519	Catalyzes the synthesis of GMP from XMP
ebA6652	COG2914	Belongs to the UPF0125 (RnfH) family
ebA6653	COG2867	negative regulation of translational initiation
ebA6654	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ebA6658	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ebA666	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ebA6661	COG0601	transmembrane transport
ebA6665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ebA6667	COG0542	response to heat
ebA6671	COG0314	molybdopterin synthase activity
ebA6672	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ebA6673	COG0303	'Molybdopterin
ebA6674	COG1763	Mo-molybdopterin cofactor biosynthetic process
ebA6678	COG1199	ATP-dependent helicase activity
ebA6682	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ebA6683	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ebA6684	COG0508	dehydrogenase complex catalyzes the overall conversion of
ebA6685	COG0567	Dehydrogenase, E1 component
ebA6687	COG0372	Belongs to the citrate synthase family
ebA6689	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ebA669	COG3177	Filamentation induced by cAMP protein fic
ebA6690	COG1053	succinate dehydrogenase
ebA6693	COG2188	Transcriptional regulator
ebA6695	COG0039	L-malate dehydrogenase activity
ebA6704	COG1132	(ABC) transporter
ebA6709	COG0668	transmembrane transport
ebA6729	COG0745	RESPONSE REGULATOR receiver
ebA6736	COG0277	FAD linked oxidase domain protein
ebA6743	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ebA6744	COG0842	Transport permease protein
ebA6744	COG1129	ABC transporter
ebA6745	COG0842	Transport permease protein
ebA6752	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ebA6753	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ebA6761	COG0129	dihydroxy-acid dehydratase activity
ebA6767	COG2124	cytochrome p450
ebA6770	COG1943	Transposase
ebA6773	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ebA6775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ebA6775	COG1017	nitric oxide dioxygenase activity
ebA6781	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ebA6795	COG0484	heat shock protein binding
ebA6797	COG0489	protein tyrosine kinase activity
ebA6802	COG4464	protein tyrosine phosphatase activity
ebA6806	COG1136	(ABC) transporter
ebA6809	COG1562	ergosterol biosynthetic process
ebA6810	COG1562	ergosterol biosynthetic process
ebA6811	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ebA6813	COG4181	ATPase activity
ebA6818	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
ebA6824	COG2205	protein histidine kinase activity
ebA6824	COG2202	Pas domain
ebA6829	COG0045	succinate-CoA ligase (ADP-forming) activity
ebA6829	COG1042	CoA-binding domain protein
ebA6829	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ebA6834	COG2183	response to ionizing radiation
ebA6837	COG0850	regulation of cytokinetic process
ebA6839	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ebA6841	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ebA6842	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ebA6842	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ebA6850	COG2197	response regulator
ebA6855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ebA6861	COG1090	epimerase
ebA6868	COG1546	Belongs to the CinA family
ebA6868	COG1058	Belongs to the CinA family
ebA6869	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ebA6875	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ebA6876	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ebA6876	COG1672	PFAM Archaeal ATPase
ebA6882	COG5265	(ABC) transporter
ebA6890	COG2205	protein histidine kinase activity
ebA690	COG4372	Transposase
ebA6902	COG2204	response regulator
ebA6907	COG0297	glycogen (starch) synthase activity
ebA6910	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ebA6912	COG0859	PFAM glycosyl transferase family 9
ebA6917	COG0297	glycogen (starch) synthase activity
ebA6918	COG1640	4-alpha-glucanotransferase
ebA6920	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ebA6921	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ebA6926	COG3264	Mechanosensitive ion channel
ebA6926	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ebA6931	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ebA6934	COG0438	transferase activity, transferring glycosyl groups
ebA6940	COG0671	phosphoesterase, PA-phosphatase related
ebA6942	COG0438	transferase activity, transferring glycosyl groups
ebA6943	COG2193	ferroxidase activity
ebA6946	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ebA6958	COG1252	NADH dehydrogenase
ebA6959	COG5487	UPF0391 membrane protein
ebA6963	COG0628	permease
ebA6964	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ebA6968	COG2823	Periplasmic or secreted lipoprotein
ebA697	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ebA6974	COG0189	ligase activity
ebA6991	COG1028	Short-chain dehydrogenase reductase Sdr
ebA6999	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ebA70	COG1484	DNA-dependent DNA replication
ebA7001	COG0366	Alpha amylase catalytic
ebA7002	COG0366	Alpha amylase catalytic
ebA7003	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ebA7008	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ebA702	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ebA7030	COG0579	oxidoreductase
ebA7034	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ebA7036	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ebA7039	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ebA7041	COG1674	ftsk spoiiie
ebA7042	COG0492	ferredoxin-NADP+ reductase activity
ebA7046	COG2840	Smr protein MutS2
ebA7048	COG0347	Belongs to the P(II) protein family
ebA7049	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ebA7049	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ebA705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ebA7053	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ebA7069	COG2813	Specifically methylates the guanine in position
ebA7072	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ebA7075	COG1028	Short-chain dehydrogenase reductase Sdr
ebA7092	COG5499	transcription regulator containing HTH domain
ebA7097	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ebA7101	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ebA7104	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ebA7105	COG0628	permease
ebA7107	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ebA7112	COG0617	tRNA 3'-terminal CCA addition
ebA7118	COG1428	Deoxynucleoside kinase
ebA7119	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ebA7120	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ebA7121	COG0516	GMP reductase activity
ebA7121	COG0517	IMP dehydrogenase activity
ebA7122	COG0308	aminopeptidase N
ebA7130	COG0028	Belongs to the TPP enzyme family
ebA7132	COG0440	acetolactate synthase activity
ebA7134	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ebA7135	COG0688	phosphatidylethanolamine metabolic process
ebA7137	COG1183	phosphatidylcholine synthase activity
ebA7143	COG2205	protein histidine kinase activity
ebA7146	COG0745	RESPONSE REGULATOR receiver
ebA7148	COG1858	cytochrome C peroxidase
ebA715	COG1309	transcriptional regulator
ebA7152	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ebA7154	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ebA7158	COG1295	ribonuclease BN
ebA7167	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ebA7168	COG0336	Belongs to the RNA methyltransferase TrmD family
ebA7169	COG0335	large ribosomal subunit rRNA binding
ebA7173	COG0795	lipopolysaccharide-transporting ATPase activity
ebA7174	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ebA7180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ebA7186	COG0525	valine-tRNA ligase activity
ebA7188	COG4783	chaperone-mediated protein folding
ebA7189	COG0315	cyclic pyranopterin monophosphate synthase activity
ebA7191	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ebA7193	COG2169	Transcriptional regulator
ebA7193	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ebA7196	COG1819	glycosyl
ebA720	COG1024	Enoyl-CoA hydratase
ebA722	COG1024	Enoyl-CoA hydratase
ebA7220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ebA7223	COG0604	alcohol dehydrogenase
ebA723	COG1028	Short-chain dehydrogenase reductase Sdr
ebA7261	COG0740	serine-type endopeptidase activity
ebA7267	COG3179	chitinase
ebA736	COG1960	acyl-CoA dehydrogenase activity
ebA748	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
ebA771	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ebA773	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ebA774	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ebA775	COG0123	including yeast histone deacetylase and acetoin utilization protein
ebA776	COG2951	lytic endotransglycosylase activity
ebA778	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ebA781	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ebA782	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ebA788	COG1484	DNA-dependent DNA replication
ebA790	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ebA811	COG0583	DNA-binding transcription factor activity
ebA816	COG0730	response to heat
ebA819	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ebA829	COG0538	isocitrate dehydrogenase activity
ebA835	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ebA837	COG0756	dUTP diphosphatase activity
ebA840	COG2003	Belongs to the UPF0758 family
ebA843	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ebA844	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ebA855	COG0432	Pfam Uncharacterised protein family UPF0047
ebA859	COG4372	Transposase
ebA864	COG3706	GGDEF domain
ebA866	COG0776	regulation of translation
ebA867	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ebA867	COG0072	phenylalanine-tRNA ligase activity
ebA868	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ebA870	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ebA871	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ebA872	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ebA875	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ebA883	COG3391	amine dehydrogenase activity
ebA885	COG1648	precorrin-2 dehydrogenase activity
ebA885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ebA900	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ebA902	COG0776	regulation of translation
ebA904	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ebA905	COG0287	Prephenate dehydrogenase
ebA907	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ebA911	COG0402	S-adenosylhomocysteine deaminase activity
ebA914	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ebA931	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ebA932	COG0739	heme binding
ebA935	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ebA937	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ebA938	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ebA942	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ebA950	COG0442	prolyl-tRNA aminoacylation
ebA951	COG0494	nUDIX hydrolase
ebA955	COG0741	lytic transglycosylase activity
ebA960	COG2205	protein histidine kinase activity
ebA966	COG2204	response regulator
ebA969	COG0312	modulator of DNA gyrase
ebA970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ebA977	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ebA986	COG0482	sulfurtransferase activity
ebA999	COG4191	Histidine kinase
ebB103	COG4115	mRNA cleavage
ebB104	COG1943	Transposase
ebB108	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ebB113	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ebB115	COG3162	membrane
ebB123	COG0222	ribosome binding
ebB124	COG0051	transcription antitermination factor activity, RNA binding
ebB125	COG0089	rRNA binding
ebB126	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ebB127	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ebB128	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ebB129	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ebB130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ebB131	COG0200	Binds to the 23S rRNA
ebB132	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ebB133	COG0203	ribosomal protein L17
ebB142	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ebB143	COG2824	Alkylphosphonate utilization operon protein PhnA
ebB144	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ebB148	COG0346	lactoylglutathione lyase activity
ebB15	COG1006	Multisubunit Na H antiporter MnhC subunit
ebB150	COG1047	Peptidyl-prolyl cis-trans
ebB154	COG2009	succinate dehydrogenase
ebB155	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ebB157	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ebB158	COG2259	Doxx family
ebB162	COG0440	acetolactate synthase activity
ebB163	COG0135	phosphoribosylanthranilate isomerase activity
ebB164	COG1286	toxin biosynthetic process
ebB166	COG1950	PFAM Membrane protein of
ebB167	COG0735	belongs to the Fur family
ebB168	COG0713	ATP synthesis coupled electron transport
ebB173	COG0640	Transcriptional regulator
ebB176	COG0848	biopolymer transport protein
ebB177	COG0268	Binds directly to 16S ribosomal RNA
ebB180	COG3094	Invasion gene expression up-regulator, SirB
ebB196	COG0736	holo-[acyl-carrier-protein] synthase activity
ebB202	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ebB205	COG2916	Histone family protein nucleoid-structuring protein H-NS
ebB206	COG2916	Histone family protein nucleoid-structuring protein H-NS
ebB208	COG2916	Histone family protein nucleoid-structuring protein H-NS
ebB211	COG2916	Histone family protein nucleoid-structuring protein H-NS
ebB213	COG3360	Dodecin
ebB214	COG3474	cytochrome
ebB217	COG0509	glycine decarboxylation via glycine cleavage system
ebB22	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ebB229	COG0633	Ferredoxin
ebB230	COG0316	Belongs to the HesB IscA family
ebB233	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ebB237	COG3077	Addiction module antitoxin, RelB DinJ family
ebB238	COG1285	pathogenesis
ebB247	COG0228	four-way junction DNA binding
ebB25	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ebB253	COG4197	protein conserved in bacteria, prophage-related
ebB30	COG0316	Belongs to the HesB IscA family
ebB31	COG1765	OsmC-like protein
ebB33	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ebB35	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ebB37	COG0105	UTP biosynthetic process
ebB38	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ebB39	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ebB40	COG1862	Preprotein translocase
ebB42	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ebB43	COG2001	Belongs to the MraZ family
ebB44	COG2165	general secretion pathway protein
ebB45	COG2165	general secretion pathway protein
ebB48	COG0352	thiamine-phosphate diphosphorylase activity
ebB5	COG2154	pterin-4-alpha-carbinolamine dehydratase
ebB6	COG2010	Cytochrome c
ebB67	COG3668	Plasmid stabilization system
ebB68	COG1396	sequence-specific DNA binding
ebB74	COG0776	regulation of translation
ebB82	COG3093	addiction module antidote protein HigA
ebB84	COG0824	Thioesterase
ebB86	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
ebB89	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ebB9	COG0511	ligase activity, forming carbon-carbon bonds
ebB90	COG0594	ribonuclease P activity
ebB91	COG0242	peptide deformylase activity
ebB95	COG0347	Belongs to the P(II) protein family
ebC1	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ebC10	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ebC12	COG1278	Cold shock
ebC2	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ebC3	COG0255	Belongs to the universal ribosomal protein uL29 family
ebC4	COG1841	ribosomal large subunit assembly
ebC5	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ebC6	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ebC7	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ebC8	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ebC9	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ebD1	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ebD103	COG2161	toxin-antitoxin pair type II binding
ebD108	COG0484	heat shock protein binding
ebD109	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ebD11	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ebD115	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ebD116	COG1943	Transposase
ebD12	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ebD14	COG3657	addiction module killer protein
ebD15	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ebD2	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ebD48	COG4453	Protein conserved in bacteria
ebD6	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ebD64	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ebD68	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ebD7	COG0517	IMP dehydrogenase activity
ebD70	COG2921	Belongs to the UPF0250 family
ebD71	COG3158	transport of potassium into the cell
ebD72	COG3437	response regulator, receiver
ebD80	COG2965	DNA replication, synthesis of RNA primer
ebD83	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ebD86	COG3123	guanosine phosphorylase activity
ebD89	COG0861	Integral membrane protein TerC family
ebD98	COG5433	transposase activity
p1B119	COG4974	Belongs to the 'phage' integrase family
p1B136	COG3153	acetyltransferase
p1B137	COG4453	Protein conserved in bacteria
p1B143	COG1192	Involved in chromosome partitioning
p1B145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
p1B164	COG2885	chlorophyll binding
p1B167	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
p1B177	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
p1B184	COG0616	signal peptide processing
p1B193	COG1484	DNA-dependent DNA replication
p1B195	COG4584	PFAM Integrase catalytic
p1B201	COG1525	nuclease
p1B237	COG2974	May be involved in recombination
p1B254	COG1714	RDD family
p1B257	COG0305	Participates in initiation and elongation during chromosome replication
p1B267	COG1484	DNA-dependent DNA replication
p1B269	COG4584	PFAM Integrase catalytic
p1B299	COG0670	Belongs to the BI1 family
p1B306	COG1358	cellular component organization or biogenesis
p1B319	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
p1B324	COG4245	von Willebrand factor, type A
p1B347	COG2176	DNA-directed DNA polymerase activity
p1B53	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
p1B79	COG1475	DNA binding
p2A104	COG1804	L-carnitine dehydratase bile acid-inducible protein F
p2A109	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
p2A122	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
p2A13	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
p2A13	COG0674	pyruvate-flavodoxin oxidoreductase activity
p2A133	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
p2A143	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
p2A16	COG1013	pyruvate-flavodoxin oxidoreductase activity
p2A173	COG4974	Belongs to the 'phage' integrase family
p2A174	COG0517	IMP dehydrogenase activity
p2A176	COG4974	Belongs to the 'phage' integrase family
p2A177	COG1484	DNA-dependent DNA replication
p2A182	COG3415	Transposase
p2A184	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
p2A189	COG4974	Belongs to the 'phage' integrase family
p2A191	COG0582	viral genome integration into host DNA
p2A192	COG4974	Belongs to the 'phage' integrase family
p2A193	COG0582	viral genome integration into host DNA
p2A194	COG4974	Belongs to the 'phage' integrase family
p2A2	COG1053	succinate dehydrogenase
p2A206	COG0655	NAD(P)H dehydrogenase (quinone) activity
p2A217	COG4974	Belongs to the 'phage' integrase family
p2A219	COG4974	Belongs to the 'phage' integrase family
p2A225	COG0582	viral genome integration into host DNA
p2A227	COG4974	Belongs to the 'phage' integrase family
p2A228	COG0582	viral genome integration into host DNA
p2A229	COG4974	Belongs to the 'phage' integrase family
p2A230	COG0582	viral genome integration into host DNA
p2A243	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
p2A244	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
p2A255	COG1484	DNA-dependent DNA replication
p2A256	COG4584	PFAM Integrase catalytic
p2A268	COG4974	Belongs to the 'phage' integrase family
p2A279	COG4372	Transposase
p2A292	COG1192	Involved in chromosome partitioning
p2A308	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
p2A311	COG3415	Transposase
p2A315	COG1484	DNA-dependent DNA replication
p2A323	COG1053	succinate dehydrogenase
p2A325	COG3039	Transposase
p2A326	COG3039	Transposase
p2A330	COG0251	oxidation-reduction process
p2A332	COG1028	Short-chain dehydrogenase reductase Sdr
p2A334	COG0604	alcohol dehydrogenase
p2A336	COG2801	Transposase and inactivated derivatives
p2A341	COG1024	Enoyl-CoA hydratase
p2A347	COG0778	Nitroreductase
p2A347	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
p2A350	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
p2A358	COG2186	Transcriptional regulator
p2A373	COG1028	Short-chain dehydrogenase reductase Sdr
p2A379	COG0667	Aldo Keto reductase
p2A380	COG1960	acyl-CoA dehydrogenase activity
p2A386	COG0318	PFAM AMP-dependent synthetase and ligase
p2A389	COG1024	Enoyl-CoA hydratase
p2A392	COG1250	3-hydroxyacyl-CoA dehydrogenase
p2A394	COG0183	Belongs to the thiolase family
p2A408	COG1250	3-hydroxyacyl-CoA dehydrogenase
p2A409	COG0183	Belongs to the thiolase family
p2A45	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
p2A58	COG0842	Transport permease protein
p2A60	COG2197	response regulator
p2A7	COG1960	acyl-CoA dehydrogenase activity
p2A96	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
p2B11	COG3846	protein secretion by the type IV secretion system
p2B17	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
p2B2	COG4962	Type ii secretion system protein e
p2B3	COG3838	Conjugal transfer protein Trbc
p2B4	COG3451	type IV secretory pathway VirB4
p2D1	COG5268	conjugation