locus-tag	class	description
ToN1_00040	COG4638	Rieske (2fe-2S)
ToN1_00050	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ToN1_00060	COG1022	Amp-dependent synthetase and ligase
ToN1_00090	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ToN1_00140	COG0252	asparaginase activity
ToN1_00150	COG1126	abc transporter atp-binding protein
ToN1_00160	COG0010	Belongs to the arginase family
ToN1_00170	COG0765	amino acid transport
ToN1_00180	COG0765	amino acid transport
ToN1_00190	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ToN1_00340	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ToN1_00440	COG1695	Transcriptional regulator
ToN1_00490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ToN1_00510	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ToN1_00540	COG0328	RNA-DNA hybrid ribonuclease activity
ToN1_00560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ToN1_00570	COG2203	Gaf domain
ToN1_00570	COG3706	GGDEF domain
ToN1_00570	COG4251	negative regulation of phosphorylation
ToN1_00570	COG5001	Diguanylate cyclase
ToN1_00580	COG1388	LysM domain
ToN1_00580	COG0741	lytic transglycosylase activity
ToN1_00620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ToN1_00630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ToN1_00670	COG0534	Mate efflux family protein
ToN1_00680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ToN1_00690	COG5002	protein histidine kinase activity
ToN1_00690	COG0784	Response regulator, receiver
ToN1_00690	COG2205	protein histidine kinase activity
ToN1_00700	COG0587	DNA-directed DNA polymerase activity
ToN1_00750	COG2154	pterin-4-alpha-carbinolamine dehydratase
ToN1_00830	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ToN1_00840	COG1140	nitrate reductase beta subunit
ToN1_00850	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ToN1_00860	COG2181	nitrate reductase activity
ToN1_00870	COG3850	Histidine kinase
ToN1_00880	COG2197	response regulator
ToN1_00900	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ToN1_00920	COG4263	nitrous-oxide reductase activity
ToN1_01040	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ToN1_01050	COG0560	Phosphoserine phosphatase
ToN1_01060	COG2866	Carboxypeptidase
ToN1_01070	COG3022	response to hydroperoxide
ToN1_01090	COG0156	8-amino-7-oxononanoate synthase activity
ToN1_01100	COG2267	carboxylic ester hydrolase activity
ToN1_01110	COG2226	methyltransferase
ToN1_01120	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ToN1_01130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ToN1_01150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ToN1_01160	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ToN1_01170	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ToN1_01180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ToN1_01190	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ToN1_01230	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ToN1_01240	COG0575	Belongs to the CDS family
ToN1_01250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ToN1_01260	COG0233	cytoplasmic translational termination
ToN1_01270	COG0528	UMP kinase activity
ToN1_01280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ToN1_01290	COG0052	Belongs to the universal ribosomal protein uS2 family
ToN1_01310	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ToN1_01320	COG2862	Uncharacterized protein family, UPF0114
ToN1_01340	COG2151	metal-sulfur cluster biosynthetic enzyme
ToN1_01520	COG1881	PFAM PEBP family protein
ToN1_01530	COG1024	Enoyl-CoA hydratase
ToN1_01580	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_01590	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_01600	COG0604	alcohol dehydrogenase
ToN1_01600	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_01600	COG3321	synthase
ToN1_01650	COG4447	cellulose binding
ToN1_01740	COG1132	(ABC) transporter
ToN1_01770	COG0641	radical SAM
ToN1_01800	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_01810	COG0826	peptidase U32
ToN1_01900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_01960	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_01970	COG0183	Belongs to the thiolase family
ToN1_02010	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_02020	COG0583	DNA-binding transcription factor activity
ToN1_02030	COG0583	DNA-binding transcription factor activity
ToN1_02060	COG1819	glycosyl
ToN1_02120	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_02130	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
ToN1_02140	COG0028	Belongs to the TPP enzyme family
ToN1_02150	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_02160	COG1414	Transcriptional regulator
ToN1_02190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ToN1_02210	COG1116	anion transmembrane transporter activity
ToN1_02240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ToN1_02250	COG2304	oxidoreductase activity
ToN1_02300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ToN1_02380	COG0183	Belongs to the thiolase family
ToN1_02410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ToN1_02420	COG2151	metal-sulfur cluster biosynthetic enzyme
ToN1_02430	COG3396	Phenylacetate-CoA oxygenase
ToN1_02440	COG3460	Phenylacetate-CoA oxygenase
ToN1_02450	COG3396	Phenylacetate-CoA oxygenase
ToN1_02460	COG4654	Cytochrome c, class I
ToN1_02490	COG2197	response regulator
ToN1_02500	COG3851	Histidine kinase
ToN1_02520	COG2204	response regulator
ToN1_02550	COG1294	oxidase, subunit
ToN1_02600	COG1960	acyl-CoA dehydrogenase activity
ToN1_02610	COG0183	Belongs to the thiolase family
ToN1_02620	COG1024	Enoyl-CoA hydratase
ToN1_02620	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_02640	COG2207	Transcriptional regulator
ToN1_02650	COG2801	Transposase and inactivated derivatives
ToN1_02660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ToN1_02680	COG0488	(ABC) transporter
ToN1_02720	COG1335	isochorismatase
ToN1_02740	COG0583	DNA-binding transcription factor activity
ToN1_02810	COG4451	ribulose bisphosphate carboxylase, small
ToN1_02830	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ToN1_02840	COG3954	Phosphoribulokinase
ToN1_02850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ToN1_02860	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ToN1_02870	COG0126	phosphoglycerate kinase activity
ToN1_02880	COG0191	fructose-bisphosphate aldolase activity
ToN1_02930	COG1595	DNA-templated transcription, initiation
ToN1_02940	COG0701	Predicted permease
ToN1_03200	COG2855	membrane
ToN1_03280	COG2197	response regulator
ToN1_03300	COG1924	4 iron, 4 sulfur cluster binding
ToN1_03330	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ToN1_03370	COG1960	acyl-CoA dehydrogenase activity
ToN1_03380	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_03410	COG0300	oxidoreductase activity
ToN1_03410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ToN1_03410	COG4221	oxidoreductase activity
ToN1_03410	COG3321	synthase
ToN1_03420	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_03470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ToN1_03480	COG2801	Transposase and inactivated derivatives
ToN1_03570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ToN1_03600	COG1013	pyruvate-flavodoxin oxidoreductase activity
ToN1_03610	COG0674	pyruvate-flavodoxin oxidoreductase activity
ToN1_03610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ToN1_03640	COG0730	response to heat
ToN1_03670	COG0183	Belongs to the thiolase family
ToN1_03690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ToN1_03700	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ToN1_03720	COG2855	membrane
ToN1_03740	COG4447	cellulose binding
ToN1_03770	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_03800	COG2146	nitrite reductase [NAD(P)H] activity
ToN1_03830	COG2175	clavaminate synthase activity
ToN1_03840	COG3246	L-lysine catabolic process to acetate
ToN1_03900	COG1953	Uracil, thiamine, allantoin
ToN1_03920	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_03950	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ToN1_03960	COG3657	addiction module killer protein
ToN1_03990	COG2409	Drug exporters of the RND superfamily
ToN1_04070	COG0583	DNA-binding transcription factor activity
ToN1_04080	COG2828	Protein conserved in bacteria
ToN1_04120	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
ToN1_04170	COG0583	DNA-binding transcription factor activity
ToN1_04180	COG1053	succinate dehydrogenase
ToN1_04210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ToN1_04220	COG2828	Protein conserved in bacteria
ToN1_04280	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ToN1_04300	COG0840	transmembrane signaling receptor activity
ToN1_04590	COG0657	acetylesterase activity
ToN1_04730	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ToN1_04740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_04760	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_04780	COG0183	Belongs to the thiolase family
ToN1_04790	COG1946	Acyl-CoA thioesterase
ToN1_04810	COG1024	Enoyl-CoA hydratase
ToN1_04820	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_04830	COG1024	Enoyl-CoA hydratase
ToN1_04840	COG1960	acyl-CoA dehydrogenase activity
ToN1_04860	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_04880	COG1960	acyl-CoA dehydrogenase activity
ToN1_04900	COG1960	acyl-CoA dehydrogenase activity
ToN1_04960	COG1960	acyl-CoA dehydrogenase activity
ToN1_04970	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_04980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_04990	COG1960	acyl-CoA dehydrogenase activity
ToN1_05000	COG1960	acyl-CoA dehydrogenase activity
ToN1_05050	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_05070	COG1960	acyl-CoA dehydrogenase activity
ToN1_05090	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_05100	COG2814	Major facilitator Superfamily
ToN1_05130	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_05140	COG2079	MmgE PrpD family protein
ToN1_05150	COG0183	Belongs to the thiolase family
ToN1_05170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_05180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ToN1_05210	COG1013	pyruvate-flavodoxin oxidoreductase activity
ToN1_05220	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ToN1_05220	COG0674	pyruvate-flavodoxin oxidoreductase activity
ToN1_05270	COG4974	Belongs to the 'phage' integrase family
ToN1_05300	COG1024	Enoyl-CoA hydratase
ToN1_05340	COG2814	Major facilitator Superfamily
ToN1_05360	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_05380	COG2030	dehydratase
ToN1_05400	COG1024	Enoyl-CoA hydratase
ToN1_05420	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ToN1_05440	COG1024	Enoyl-CoA hydratase
ToN1_05450	COG1960	acyl-CoA dehydrogenase activity
ToN1_05460	COG1960	acyl-CoA dehydrogenase activity
ToN1_05470	COG1024	Enoyl-CoA hydratase
ToN1_05480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_05490	COG1960	acyl-CoA dehydrogenase activity
ToN1_05500	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
ToN1_05530	COG2301	Belongs to the HpcH HpaI aldolase family
ToN1_05560	COG2030	dehydratase
ToN1_05570	COG0183	Belongs to the thiolase family
ToN1_05590	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_05600	COG1024	Enoyl-CoA hydratase
ToN1_05610	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_05620	COG1024	Enoyl-CoA hydratase
ToN1_05640	COG1024	Enoyl-CoA hydratase
ToN1_05710	COG4447	cellulose binding
ToN1_05730	COG2801	Transposase and inactivated derivatives
ToN1_05760	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_05770	COG1024	Enoyl-CoA hydratase
ToN1_05780	COG2365	Tyrosine phosphatase family
ToN1_05800	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_05930	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ToN1_05970	COG2814	Major facilitator Superfamily
ToN1_06000	COG1063	alcohol dehydrogenase
ToN1_06010	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_06020	COG1024	Enoyl-CoA hydratase
ToN1_06100	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_06110	COG0179	Fumarylacetoacetate (FAA) hydrolase
ToN1_06180	COG2223	nitrite transmembrane transporter activity
ToN1_06210	COG0179	Fumarylacetoacetate (FAA) hydrolase
ToN1_06220	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_06350	COG2086	electron transfer activity
ToN1_06370	COG0583	DNA-binding transcription factor activity
ToN1_06375	COG2204	response regulator
ToN1_06380	COG0571	ribonuclease III activity
ToN1_06420	COG0302	gtp cyclohydrolase
ToN1_06440	COG1024	Enoyl-CoA hydratase
ToN1_06450	COG1960	acyl-CoA dehydrogenase activity
ToN1_06460	COG1960	acyl-CoA dehydrogenase activity
ToN1_06480	COG2124	cytochrome p450
ToN1_06490	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_06530	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_06540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_06600	COG1233	COG1233 Phytoene dehydrogenase and related
ToN1_06650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ToN1_06690	COG0427	acetyl-CoA hydrolase
ToN1_06700	COG0183	Belongs to the thiolase family
ToN1_06740	COG2365	Tyrosine phosphatase family
ToN1_06750	COG0183	Belongs to the thiolase family
ToN1_06890	COG1960	acyl-CoA dehydrogenase activity
ToN1_06900	COG1902	pentaerythritol trinitrate reductase activity
ToN1_06910	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_06940	COG2030	dehydratase
ToN1_06950	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_06950	COG1024	Enoyl-CoA hydratase
ToN1_06960	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ToN1_06970	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_07000	COG1960	acyl-CoA dehydrogenase activity
ToN1_07010	COG0596	Alpha beta hydrolase
ToN1_07030	COG0714	Associated with various cellular activities
ToN1_07080	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ToN1_07090	COG1140	nitrate reductase beta subunit
ToN1_07120	COG5001	Diguanylate cyclase
ToN1_07200	COG1845	cytochrome c oxidase, subunit III
ToN1_07290	COG0574	Belongs to the PEP-utilizing enzyme family
ToN1_07290	COG3848	Pyruvate phosphate dikinase
ToN1_07340	COG1024	Enoyl-CoA hydratase
ToN1_07350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_07450	COG4221	oxidoreductase activity
ToN1_07550	COG1192	Involved in chromosome partitioning
ToN1_07790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ToN1_07860	COG0484	heat shock protein binding
ToN1_07870	COG2003	Belongs to the UPF0758 family
ToN1_07980	COG5002	protein histidine kinase activity
ToN1_07990	COG1674	ftsk spoiiie
ToN1_08120	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ToN1_08160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ToN1_08170	COG1185	polyribonucleotide nucleotidyltransferase activity
ToN1_08190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ToN1_08200	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ToN1_08210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ToN1_08220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ToN1_08230	COG2251	uridine kinase activity
ToN1_08230	COG0195	Participates in both transcription termination and antitermination
ToN1_08240	COG0779	Required for maturation of 30S ribosomal subunits
ToN1_08260	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ToN1_08270	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ToN1_08280	COG0180	Tryptophanyl-tRNA synthetase
ToN1_08290	COG1994	Peptidase M50
ToN1_08300	COG0009	L-threonylcarbamoyladenylate synthase
ToN1_08310	COG0613	PHP domain protein
ToN1_08330	COG0509	glycine decarboxylation via glycine cleavage system
ToN1_08340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ToN1_08340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ToN1_08360	COG1215	transferase activity, transferring glycosyl groups
ToN1_08370	COG0583	DNA-binding transcription factor activity
ToN1_08400	COG0508	dehydrogenase complex catalyzes the overall conversion of
ToN1_08420	COG0488	(ABC) transporter
ToN1_08460	COG0577	efflux transmembrane transporter activity
ToN1_08470	COG1136	(ABC) transporter
ToN1_08490	COG3447	MASE1 domain protein
ToN1_08490	COG5001	Diguanylate cyclase
ToN1_08490	COG5002	protein histidine kinase activity
ToN1_08500	COG1562	ergosterol biosynthetic process
ToN1_08520	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ToN1_08530	COG4181	ATPase activity
ToN1_08560	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
ToN1_08580	COG4191	Histidine kinase
ToN1_08610	COG1132	(ABC) transporter
ToN1_08670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ToN1_08670	COG1042	CoA-binding domain protein
ToN1_08670	COG0045	succinate-CoA ligase (ADP-forming) activity
ToN1_08690	COG2183	response to ionizing radiation
ToN1_08700	COG1393	Belongs to the ArsC family
ToN1_08720	COG0850	regulation of cytokinetic process
ToN1_08740	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ToN1_08760	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ToN1_08770	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ToN1_08770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ToN1_08780	COG4585	Histidine kinase
ToN1_08790	COG2197	response regulator
ToN1_08850	COG3848	Pyruvate phosphate dikinase
ToN1_08850	COG0574	Belongs to the PEP-utilizing enzyme family
ToN1_08870	COG0517	IMP dehydrogenase activity
ToN1_08890	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ToN1_08920	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ToN1_08960	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ToN1_09000	COG2816	NAD+ diphosphatase activity
ToN1_09010	COG0450	alkyl hydroperoxide reductase
ToN1_09020	COG3634	alkyl hydroperoxide reductase activity
ToN1_09070	COG2202	Pas domain
ToN1_09070	COG2205	protein histidine kinase activity
ToN1_09150	COG2204	response regulator
ToN1_09170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ToN1_09180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_09200	COG1538	Outer membrane efflux protein
ToN1_09210	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ToN1_09250	COG0515	serine threonine protein kinase
ToN1_09260	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ToN1_09290	COG1960	acyl-CoA dehydrogenase activity
ToN1_09310	COG0183	Belongs to the thiolase family
ToN1_09320	COG1024	Enoyl-CoA hydratase
ToN1_09330	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_09400	COG4191	Histidine kinase
ToN1_09430	COG2151	metal-sulfur cluster biosynthetic enzyme
ToN1_09450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ToN1_09460	COG0719	Fe-S assembly protein
ToN1_09470	COG0396	ATPase activity
ToN1_09480	COG0719	Fe-S assembly protein
ToN1_09490	COG1067	ATP-dependent peptidase activity
ToN1_09500	COG1335	isochorismatase
ToN1_09520	COG1881	PFAM PEBP family protein
ToN1_09560	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ToN1_09570	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ToN1_09590	COG1196	nuclear chromosome segregation
ToN1_09610	COG2171	N-acyltransferase activity
ToN1_09630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ToN1_09650	COG0784	Response regulator, receiver
ToN1_09670	COG0633	Ferredoxin
ToN1_09680	COG0443	Heat shock 70 kDa protein
ToN1_09690	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ToN1_09710	COG0822	iron-sulfur transferase activity
ToN1_09720	COG1104	cysteine desulfurase activity
ToN1_09730	COG1104	cysteine desulfurase activity
ToN1_09750	COG1045	serine acetyltransferase
ToN1_09770	COG0483	inositol monophosphate 1-phosphatase activity
ToN1_09780	COG0513	Belongs to the DEAD box helicase family
ToN1_09820	COG0322	excinuclease ABC activity
ToN1_09830	COG1472	Belongs to the glycosyl hydrolase 3 family
ToN1_09840	COG0736	holo-[acyl-carrier-protein] synthase activity
ToN1_09850	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ToN1_09860	COG1381	Involved in DNA repair and RecF pathway recombination
ToN1_09870	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ToN1_09880	COG0571	ribonuclease III activity
ToN1_09900	COG0681	Belongs to the peptidase S26 family
ToN1_09910	COG0481	GTPase activity
ToN1_09930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ToN1_09980	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ToN1_10010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ToN1_10040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ToN1_10050	COG0416	fatty acid biosynthetic process
ToN1_10060	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ToN1_10070	COG1399	metal-binding, possibly nucleic acid-binding protein
ToN1_10080	COG0424	maF-like protein
ToN1_10090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ToN1_10100	COG0546	phosphoglycolate phosphatase activity
ToN1_10120	COG1530	ribonuclease E activity
ToN1_10130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ToN1_10140	COG0556	nucleotide-excision repair
ToN1_10170	COG1067	ATP-dependent peptidase activity
ToN1_10190	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ToN1_10230	COG1473	amidohydrolase
ToN1_10260	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ToN1_10290	COG0717	Belongs to the dCTP deaminase family
ToN1_10320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ToN1_10320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ToN1_10330	COG0659	secondary active sulfate transmembrane transporter activity
ToN1_10340	COG1254	Belongs to the acylphosphatase family
ToN1_10380	COG0840	transmembrane signaling receptor activity
ToN1_10400	COG0450	alkyl hydroperoxide reductase
ToN1_10450	COG0280	phosphate acetyltransferase
ToN1_10450	COG0281	malic enzyme
ToN1_10460	COG1192	Involved in chromosome partitioning
ToN1_10470	COG0210	DNA helicase
ToN1_10500	COG0495	leucyl-tRNA aminoacylation
ToN1_10520	COG1466	dna polymerase III delta subunit
ToN1_10530	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ToN1_10550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ToN1_10560	COG4974	Belongs to the 'phage' integrase family
ToN1_10580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ToN1_10610	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ToN1_10620	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ToN1_10630	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ToN1_10830	COG1305	Transglutaminase-like
ToN1_10880	COG2308	Evidence 4 Homologs of previously reported genes of
ToN1_10950	COG0730	response to heat
ToN1_10960	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ToN1_10990	COG4206	TonB-dependent receptor
ToN1_11060	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ToN1_11080	COG0538	isocitrate dehydrogenase activity
ToN1_11100	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ToN1_11140	COG0446	pyridine nucleotide-disulphide oxidoreductase
ToN1_11160	COG0756	dUTP diphosphatase activity
ToN1_11170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ToN1_11180	COG2003	Belongs to the UPF0758 family
ToN1_11190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ToN1_11200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ToN1_11210	COG1278	Cold shock
ToN1_11220	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ToN1_11230	COG0542	response to heat
ToN1_11240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ToN1_11300	COG0583	DNA-binding transcription factor activity
ToN1_11330	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ToN1_11340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ToN1_11380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ToN1_11400	COG0802	atpase or kinase
ToN1_11410	COG0860	N-Acetylmuramoyl-L-alanine amidase
ToN1_11420	COG0196	riboflavin kinase activity
ToN1_11430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ToN1_11440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ToN1_11450	COG1047	Peptidyl-prolyl cis-trans
ToN1_11460	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ToN1_11500	COG1722	exodeoxyribonuclease VII activity
ToN1_11510	COG0142	geranyltranstransferase activity
ToN1_11520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ToN1_11530	COG1469	GTP cyclohydrolase I activity
ToN1_11540	COG2030	dehydratase
ToN1_11560	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ToN1_11570	COG0142	geranyltranstransferase activity
ToN1_11580	COG0584	glycerophosphoryl diester phosphodiesterase
ToN1_11610	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ToN1_11620	COG0513	Belongs to the DEAD box helicase family
ToN1_11660	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ToN1_11680	COG0598	Magnesium transport protein CorA
ToN1_11690	COG0631	protein serine/threonine phosphatase activity
ToN1_11700	COG0247	lactate metabolic process
ToN1_11710	COG0277	FAD linked oxidase domain protein
ToN1_11730	COG0277	FAD linked oxidase domain protein
ToN1_11750	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ToN1_11760	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ToN1_11770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ToN1_11780	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ToN1_11890	COG1459	type II secretion system
ToN1_11900	COG0741	lytic transglycosylase activity
ToN1_11910	COG1819	glycosyl
ToN1_11960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ToN1_11980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_11990	COG0745	RESPONSE REGULATOR receiver
ToN1_12000	COG0604	alcohol dehydrogenase
ToN1_12020	COG1704	LemA family
ToN1_12040	COG0488	(ABC) transporter
ToN1_12070	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ToN1_12100	COG2204	response regulator
ToN1_12110	COG5002	protein histidine kinase activity
ToN1_12120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ToN1_12130	COG2801	Transposase and inactivated derivatives
ToN1_12150	COG0657	acetylesterase activity
ToN1_12220	COG2226	methyltransferase
ToN1_12250	COG2188	Transcriptional regulator
ToN1_12260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_12270	COG1960	acyl-CoA dehydrogenase activity
ToN1_12310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ToN1_12340	COG0154	amidase activity
ToN1_12440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ToN1_12450	COG1126	abc transporter atp-binding protein
ToN1_12460	COG0765	amino acid transport
ToN1_12470	COG0765	amino acid transport
ToN1_12490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ToN1_12500	COG1073	alpha beta
ToN1_12530	COG1953	Uracil, thiamine, allantoin
ToN1_12570	COG1953	Uracil, thiamine, allantoin
ToN1_12580	COG4266	Belongs to the allantoicase family
ToN1_12590	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
ToN1_12620	COG0402	S-adenosylhomocysteine deaminase activity
ToN1_12680	COG2252	PERMEase
ToN1_12720	COG2233	PERMEase
ToN1_12740	COG3195	allantoin biosynthetic process
ToN1_12740	COG3648	Uricase
ToN1_12770	COG1301	dicarboxylic acid transport
ToN1_12780	COG4266	Belongs to the allantoicase family
ToN1_12790	COG4266	Belongs to the allantoicase family
ToN1_12850	COG2319	Wd-40 repeat
ToN1_12850	COG4249	Peptidase C14 caspase catalytic subunit p20
ToN1_12920	COG3409	Peptidoglycan-binding domain 1 protein
ToN1_12920	COG3267	Type II secretory pathway component ExeA
ToN1_12940	COG0583	DNA-binding transcription factor activity
ToN1_12980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ToN1_12990	COG0456	acetyltransferase
ToN1_13030	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ToN1_13050	COG1742	UPF0060 membrane protein
ToN1_13090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ToN1_13120	COG2201	protein-glutamate methylesterase activity
ToN1_13190	COG3960	tartronate-semialdehyde synthase activity
ToN1_13200	COG3622	Belongs to the hyi family
ToN1_13210	COG2084	Dehydrogenase
ToN1_13250	COG0469	pyruvate kinase activity
ToN1_13260	COG2259	Doxx family
ToN1_13280	COG3260	NADH ubiquinone oxidoreductase 20
ToN1_13290	COG0649	NAD binding
ToN1_13300	COG0651	ATP synthesis coupled electron transport
ToN1_13320	COG0650	Formate hydrogenlyase subunit 4
ToN1_13330	COG0651	ATP synthesis coupled electron transport
ToN1_13370	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ToN1_13380	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ToN1_13390	COG0697	spore germination
ToN1_13400	COG0004	ammonium transporteR
ToN1_13440	COG0604	alcohol dehydrogenase
ToN1_13450	COG1309	transcriptional regulator
ToN1_13480	COG3135	benzoate transporter
ToN1_13490	COG1396	sequence-specific DNA binding
ToN1_13560	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ToN1_13560	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ToN1_13580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ToN1_13610	COG2022	thiamine diphosphate biosynthetic process
ToN1_13630	COG2855	membrane
ToN1_13650	COG1113	amino acid transport
ToN1_13720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ToN1_13770	COG0730	response to heat
ToN1_13800	COG1414	Transcriptional regulator
ToN1_13810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ToN1_13830	COG2733	membrane
ToN1_13870	COG0861	Integral membrane protein TerC family
ToN1_13880	COG5002	protein histidine kinase activity
ToN1_13940	COG0642	Histidine kinase
ToN1_13950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ToN1_14020	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ToN1_14050	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ToN1_14070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ToN1_14080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_14090	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ToN1_14100	COG0628	permease
ToN1_14110	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ToN1_14130	COG0617	tRNA 3'-terminal CCA addition
ToN1_14140	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ToN1_14160	COG1428	Deoxynucleoside kinase
ToN1_14170	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ToN1_14180	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ToN1_14190	COG0517	IMP dehydrogenase activity
ToN1_14190	COG0516	GMP reductase activity
ToN1_14200	COG0308	aminopeptidase N
ToN1_14250	COG0028	Belongs to the TPP enzyme family
ToN1_14270	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ToN1_14280	COG0688	phosphatidylethanolamine metabolic process
ToN1_14290	COG1183	phosphatidylcholine synthase activity
ToN1_14310	COG1368	sulfuric ester hydrolase activity
ToN1_14380	COG1858	cytochrome C peroxidase
ToN1_14420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ToN1_14450	COG1295	ribonuclease BN
ToN1_14470	COG0228	four-way junction DNA binding
ToN1_14480	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ToN1_14490	COG0336	Belongs to the RNA methyltransferase TrmD family
ToN1_14500	COG0335	large ribosomal subunit rRNA binding
ToN1_14520	COG0527	aspartate kinase activity
ToN1_14560	COG0720	synthase
ToN1_14570	COG1196	nuclear chromosome segregation
ToN1_14570	COG3264	Mechanosensitive ion channel
ToN1_14580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ToN1_14590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ToN1_14590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ToN1_14610	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ToN1_14620	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ToN1_14650	COG0187	DNA topoisomerase II activity
ToN1_14680	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ToN1_14690	COG1984	allophanate hydrolase subunit 2
ToN1_14700	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ToN1_14710	COG2814	Major facilitator Superfamily
ToN1_14720	COG4336	lyase activity
ToN1_14730	COG0583	DNA-binding transcription factor activity
ToN1_14780	COG1360	Flagellar Motor Protein
ToN1_14790	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ToN1_14830	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ToN1_14870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ToN1_14900	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ToN1_14910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ToN1_14920	COG0123	including yeast histone deacetylase and acetoin utilization protein
ToN1_14930	COG0714	Associated with various cellular activities
ToN1_14960	COG2951	lytic endotransglycosylase activity
ToN1_14970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ToN1_14990	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ToN1_15000	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ToN1_15020	COG0776	regulation of translation
ToN1_15030	COG0072	phenylalanine-tRNA ligase activity
ToN1_15030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ToN1_15040	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ToN1_15050	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ToN1_15060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ToN1_15070	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ToN1_15080	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ToN1_15100	COG0535	radical SAM domain protein
ToN1_15140	COG3391	amine dehydrogenase activity
ToN1_15160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ToN1_15160	COG1648	precorrin-2 dehydrogenase activity
ToN1_15220	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ToN1_15240	COG0776	regulation of translation
ToN1_15260	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ToN1_15270	COG0287	Prephenate dehydrogenase
ToN1_15290	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ToN1_15310	COG0402	S-adenosylhomocysteine deaminase activity
ToN1_15330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ToN1_15420	COG0346	lactoylglutathione lyase activity
ToN1_15460	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ToN1_15530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ToN1_15580	COG0494	nUDIX hydrolase
ToN1_15600	COG0071	Belongs to the small heat shock protein (HSP20) family
ToN1_15610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ToN1_15630	COG0175	sulfate reduction
ToN1_15650	COG3273	potassium ion transport
ToN1_15650	COG0471	metal ion transport
ToN1_15660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ToN1_15700	COG5652	VanZ like family
ToN1_15750	COG0463	Glycosyl transferase, family 2
ToN1_15770	COG1215	transferase activity, transferring glycosyl groups
ToN1_15790	COG1215	transferase activity, transferring glycosyl groups
ToN1_15800	COG1216	Glycosyl transferase, family 2
ToN1_15810	COG3119	arylsulfatase activity
ToN1_15830	COG0297	glycogen (starch) synthase activity
ToN1_15850	COG1696	Membrane protein involved in D-alanine export
ToN1_15880	COG0367	asparagine synthase
ToN1_15900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ToN1_15930	COG0438	transferase activity, transferring glycosyl groups
ToN1_15960	COG0367	asparagine synthase
ToN1_15970	COG0438	transferase activity, transferring glycosyl groups
ToN1_16010	COG3409	Peptidoglycan-binding domain 1 protein
ToN1_16010	COG3267	Type II secretory pathway component ExeA
ToN1_16030	COG0489	protein tyrosine kinase activity
ToN1_16070	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ToN1_16080	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ToN1_16100	COG1999	signal sequence binding
ToN1_16110	COG0109	protoheme IX farnesyltransferase activity
ToN1_16170	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ToN1_16190	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ToN1_16220	COG0300	oxidoreductase activity
ToN1_16260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ToN1_16310	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ToN1_16320	COG2205	protein histidine kinase activity
ToN1_16350	COG0514	ATP-dependent DNA helicase (RecQ)
ToN1_16380	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ToN1_16410	COG0443	Heat shock 70 kDa protein
ToN1_16430	COG0733	neurotransmitter:sodium symporter activity
ToN1_16440	COG1522	sequence-specific DNA binding
ToN1_16460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ToN1_16470	COG2911	Protein conserved in bacteria
ToN1_16480	COG0134	indole-3-glycerol-phosphate synthase activity
ToN1_16490	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ToN1_16520	COG0546	phosphoglycolate phosphatase activity
ToN1_16530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ToN1_16540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ToN1_16570	COG0631	protein serine/threonine phosphatase activity
ToN1_16580	COG2423	ornithine cyclodeaminase activity
ToN1_16590	COG0583	DNA-binding transcription factor activity
ToN1_16610	COG3842	ATPase activity
ToN1_16620	COG1176	ABC-type spermidine putrescine transport system, permease component I
ToN1_16640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ToN1_16700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ToN1_16760	COG4566	intracellular signal transduction
ToN1_16770	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ToN1_16780	COG0037	tRNA processing
ToN1_16790	COG0825	malonyl-CoA metabolic process
ToN1_16810	COG1253	flavin adenine dinucleotide binding
ToN1_16820	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ToN1_16830	COG0670	Belongs to the BI1 family
ToN1_16850	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ToN1_16860	COG0343	queuine tRNA-ribosyltransferase activity
ToN1_16870	COG1862	Preprotein translocase
ToN1_16880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ToN1_16890	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ToN1_16900	COG2095	MarC family integral membrane protein
ToN1_16930	COG2967	ApaG domain
ToN1_16940	COG4191	Histidine kinase
ToN1_16940	COG0784	Response regulator, receiver
ToN1_16950	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ToN1_16970	COG0653	protein targeting
ToN1_17010	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ToN1_17020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ToN1_17050	COG1181	Belongs to the D-alanine--D-alanine ligase family
ToN1_17060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ToN1_17070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ToN1_17080	COG0772	Belongs to the SEDS family
ToN1_17090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ToN1_17100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ToN1_17110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ToN1_17120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ToN1_17150	COG0275	rRNA processing
ToN1_17160	COG2001	Belongs to the MraZ family
ToN1_17180	COG0418	dihydroorotase activity
ToN1_17190	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ToN1_17200	COG0792	nuclease activity
ToN1_17210	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ToN1_17220	COG2823	Periplasmic or secreted lipoprotein
ToN1_17230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ToN1_17250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ToN1_17260	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ToN1_17270	COG0511	ligase activity, forming carbon-carbon bonds
ToN1_17280	COG0439	Biotin carboxylase
ToN1_17290	COG2264	protein methyltransferase activity
ToN1_17330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ToN1_17340	COG0537	adenosine 5'-monophosphoramidase activity
ToN1_17370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ToN1_17390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ToN1_17400	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ToN1_17440	COG1215	transferase activity, transferring glycosyl groups
ToN1_17470	COG1086	Polysaccharide biosynthesis protein
ToN1_17520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ToN1_17530	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ToN1_17530	COG0662	Cupin 2, conserved barrel domain protein
ToN1_17580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ToN1_17590	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ToN1_17620	COG1309	transcriptional regulator
ToN1_17670	COG2119	membrane
ToN1_17730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ToN1_17760	COG0351	phosphomethylpyrimidine kinase
ToN1_17770	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ToN1_17780	COG3258	Cytochrome c
ToN1_17810	COG1968	undecaprenyl-diphosphatase activity
ToN1_17820	COG3150	esterase
ToN1_17830	COG2226	methyltransferase
ToN1_17840	COG2962	Rard protein
ToN1_17850	COG0557	exoribonuclease II activity
ToN1_17870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ToN1_17880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ToN1_17900	COG2239	Acts as a magnesium transporter
ToN1_17910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ToN1_17920	COG0352	thiamine-phosphate diphosphorylase activity
ToN1_17930	COG0351	phosphomethylpyrimidine kinase
ToN1_17980	COG0840	transmembrane signaling receptor activity
ToN1_17990	COG2198	Histidine kinase
ToN1_17990	COG0643	Histidine kinase
ToN1_18000	COG0415	Belongs to the DNA photolyase family
ToN1_18010	COG1678	Uncharacterized ACR, COG1678
ToN1_18020	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ToN1_18030	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ToN1_18040	COG0540	Belongs to the ATCase OTCase family
ToN1_18060	COG1872	DUF167
ToN1_18070	COG0762	integral membrane protein
ToN1_18130	COG1981	membrane
ToN1_18140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ToN1_18160	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ToN1_18220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ToN1_18260	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ToN1_18260	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ToN1_18290	COG2200	EAL domain
ToN1_18290	COG2199	diguanylate cyclase activity
ToN1_18310	COG2197	response regulator
ToN1_18320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_18330	COG2274	protein secretion by the type I secretion system
ToN1_18350	COG0735	belongs to the Fur family
ToN1_18370	COG1121	(ABC) transporter
ToN1_18390	COG0803	Belongs to the bacterial solute-binding protein 9 family
ToN1_18400	COG1280	lysine exporter protein (LysE YggA)
ToN1_18440	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ToN1_18450	COG0129	dihydroxy-acid dehydratase activity
ToN1_18460	COG3132	Protein of unknown function, DUF480
ToN1_18470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ToN1_18600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_18610	COG0577	efflux transmembrane transporter activity
ToN1_18610	COG1136	(ABC) transporter
ToN1_18670	COG0672	)-iron permease
ToN1_18760	COG3781	membrane
ToN1_18820	COG5002	protein histidine kinase activity
ToN1_18890	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ToN1_18900	COG4969	Belongs to the N-Me-Phe pilin family
ToN1_18910	COG3307	-O-antigen
ToN1_18950	COG0436	Aminotransferase
ToN1_18960	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ToN1_18970	COG0235	Class ii aldolase
ToN1_18980	COG2084	Dehydrogenase
ToN1_18990	COG2084	Dehydrogenase
ToN1_19000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ToN1_19020	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ToN1_19040	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ToN1_19100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ToN1_19140	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ToN1_19180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_19230	COG4647	ligase activity
ToN1_19240	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
ToN1_19250	COG0145	ligase activity
ToN1_19280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ToN1_19340	COG0629	single-stranded DNA binding
ToN1_19350	COG2814	Major facilitator Superfamily
ToN1_19380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ToN1_19390	COG0203	ribosomal protein L17
ToN1_19410	COG0202	RNA polymerase activity
ToN1_19420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ToN1_19430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ToN1_19440	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ToN1_19450	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ToN1_19460	COG0201	protein transport
ToN1_19470	COG0200	Binds to the 23S rRNA
ToN1_19480	COG1841	ribosomal large subunit assembly
ToN1_19490	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ToN1_19500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ToN1_19510	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ToN1_19520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ToN1_19530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ToN1_19540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ToN1_19550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ToN1_19560	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ToN1_19570	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ToN1_19580	COG0255	Belongs to the universal ribosomal protein uL29 family
ToN1_19590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ToN1_19600	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ToN1_19610	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ToN1_19620	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ToN1_19630	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ToN1_19640	COG0089	rRNA binding
ToN1_19650	COG0088	Forms part of the polypeptide exit tunnel
ToN1_19660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ToN1_19670	COG0051	transcription antitermination factor activity, RNA binding
ToN1_19680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ToN1_19690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ToN1_19700	COG0049	tRNA binding
ToN1_19710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ToN1_19720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ToN1_19730	COG0085	RNA polymerase activity
ToN1_19740	COG0222	ribosome binding
ToN1_19750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ToN1_19760	COG0081	regulation of translation
ToN1_19770	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ToN1_19790	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ToN1_19800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ToN1_19830	COG0277	FAD linked oxidase domain protein
ToN1_19870	COG2197	response regulator
ToN1_19900	COG3437	response regulator, receiver
ToN1_19900	COG2205	protein histidine kinase activity
ToN1_19900	COG4999	Histidine kinase
ToN1_19900	COG3850	Histidine kinase
ToN1_19930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_20000	COG1022	Amp-dependent synthetase and ligase
ToN1_20080	COG0586	Pfam SNARE associated Golgi protein
ToN1_20090	COG4251	negative regulation of phosphorylation
ToN1_20090	COG5001	Diguanylate cyclase
ToN1_20090	COG3706	GGDEF domain
ToN1_20090	COG2203	Gaf domain
ToN1_20100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ToN1_20110	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ToN1_20110	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ToN1_20110	COG1703	isobutyryl-CoA mutase activity
ToN1_20170	COG3746	phosphate-selective porin O and P
ToN1_20200	COG2321	neutral zinc metallopeptidase
ToN1_20210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ToN1_20250	COG4770	biotin carboxylase activity
ToN1_20270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ToN1_20280	COG1703	isobutyryl-CoA mutase activity
ToN1_20290	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ToN1_20290	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ToN1_20300	COG1802	Transcriptional regulator
ToN1_20310	COG0114	fumarate hydratase activity
ToN1_20350	COG0745	RESPONSE REGULATOR receiver
ToN1_20430	COG4964	Belongs to the GSP D family
ToN1_20530	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ToN1_20540	COG3162	membrane
ToN1_20550	COG1024	Enoyl-CoA hydratase
ToN1_20560	COG1492	cobalamin metabolic process
ToN1_20570	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ToN1_20590	COG1242	4 iron, 4 sulfur cluster binding
ToN1_20600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ToN1_20620	COG0513	Belongs to the DEAD box helicase family
ToN1_20670	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
ToN1_20750	COG0427	acetyl-CoA hydrolase
ToN1_20760	COG2030	dehydratase
ToN1_20770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ToN1_20800	COG0583	DNA-binding transcription factor activity
ToN1_20810	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_20820	COG0393	Putative heavy-metal-binding
ToN1_20830	COG1280	lysine exporter protein (LysE YggA)
ToN1_20860	COG0545	Peptidyl-prolyl cis-trans isomerase
ToN1_20900	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ToN1_20950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ToN1_20960	COG3474	cytochrome
ToN1_20980	COG1595	DNA-templated transcription, initiation
ToN1_20990	COG2197	response regulator
ToN1_21020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ToN1_21030	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ToN1_21040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ToN1_21060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ToN1_21070	COG2186	Transcriptional regulator
ToN1_21080	COG2423	ornithine cyclodeaminase activity
ToN1_21090	COG0006	proline dipeptidase activity
ToN1_21100	COG0006	proline dipeptidase activity
ToN1_21110	COG3608	succinylglutamate desuccinylase aspartoacylase
ToN1_21130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ToN1_21150	COG0508	dehydrogenase complex catalyzes the overall conversion of
ToN1_21210	COG4974	Belongs to the 'phage' integrase family
ToN1_21220	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ToN1_21270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ToN1_21310	COG0070	glutamate synthase
ToN1_21310	COG0069	glutamate synthase activity
ToN1_21310	COG0067	glutamate synthase
ToN1_21330	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ToN1_21340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ToN1_21350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ToN1_21420	COG1965	Belongs to the frataxin family
ToN1_21510	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ToN1_21520	COG0284	orotidine-5'-phosphate decarboxylase activity
ToN1_21540	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ToN1_21550	COG3161	chorismate lyase activity
ToN1_21570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ToN1_21590	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ToN1_21630	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ToN1_21680	COG1858	cytochrome C peroxidase
ToN1_21690	COG1741	Belongs to the pirin family
ToN1_21710	COG0183	Belongs to the thiolase family
ToN1_21720	COG1024	Enoyl-CoA hydratase
ToN1_21720	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_21740	COG2067	long-chain fatty acid transport protein
ToN1_21780	COG1960	acyl-CoA dehydrogenase activity
ToN1_21800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ToN1_21810	COG0583	DNA-binding transcription factor activity
ToN1_21820	COG0288	reversible hydration of carbon dioxide
ToN1_21850	COG4178	(ABC) transporter
ToN1_21870	COG0366	Alpha amylase catalytic
ToN1_21890	COG5265	(ABC) transporter
ToN1_21910	COG0252	asparaginase activity
ToN1_21920	COG0583	DNA-binding transcription factor activity
ToN1_21930	COG0730	response to heat
ToN1_21960	COG0175	sulfate reduction
ToN1_21980	COG0175	sulfate reduction
ToN1_22000	COG2895	sulfate adenylyltransferase (ATP) activity
ToN1_22030	COG0330	HflC and HflK could
ToN1_22060	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ToN1_22070	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ToN1_22090	COG0824	Thioesterase
ToN1_22130	COG0823	Involved in the tonB-independent uptake of proteins
ToN1_22160	COG0602	queuosine metabolic process
ToN1_22170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ToN1_22190	COG2204	response regulator
ToN1_22210	COG3300	MHYT domain
ToN1_22210	COG5001	Diguanylate cyclase
ToN1_22220	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_22300	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ToN1_22310	COG1546	Belongs to the CinA family
ToN1_22320	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ToN1_22330	COG2137	regulation of response to DNA damage stimulus
ToN1_22340	COG1137	ATPase activity
ToN1_22350	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ToN1_22360	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ToN1_22380	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ToN1_22390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ToN1_22400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ToN1_22410	COG0741	lytic transglycosylase activity
ToN1_22440	COG0617	tRNA 3'-terminal CCA addition
ToN1_22500	COG0037	tRNA processing
ToN1_22520	COG1238	metal cluster binding
ToN1_22530	COG0251	oxidation-reduction process
ToN1_22560	COG1132	(ABC) transporter
ToN1_22600	COG0243	molybdopterin cofactor binding
ToN1_22620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ToN1_22630	COG0708	Exodeoxyribonuclease III
ToN1_22640	COG1917	Cupin 2, conserved barrel domain protein
ToN1_22640	COG2207	Transcriptional regulator
ToN1_22700	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ToN1_22710	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ToN1_22790	COG2814	Major facilitator Superfamily
ToN1_22820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ToN1_22860	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ToN1_22900	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ToN1_22930	COG0861	Integral membrane protein TerC family
ToN1_22960	COG4206	TonB-dependent receptor
ToN1_22980	COG3876	Protein conserved in bacteria
ToN1_23000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ToN1_23210	COG0179	Fumarylacetoacetate (FAA) hydrolase
ToN1_23220	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_23260	COG0826	peptidase U32
ToN1_23280	COG0826	peptidase U32
ToN1_23290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ToN1_23300	COG2814	Major facilitator Superfamily
ToN1_23310	COG0606	chelatase, subunit chli
ToN1_23340	COG0347	Belongs to the P(II) protein family
ToN1_23350	COG0004	ammonium transporteR
ToN1_23400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ToN1_23420	COG0488	(ABC) transporter
ToN1_23450	COG0697	spore germination
ToN1_23470	COG0189	ligase activity
ToN1_23490	COG0732	type I restriction modification DNA specificity domain
ToN1_23490	COG0827	DNA restriction-modification system
ToN1_23530	COG1404	Belongs to the peptidase S8 family
ToN1_23540	COG1561	YicC-like family, N-terminal region
ToN1_23550	COG2815	serine threonine protein kinase
ToN1_23550	COG0515	serine threonine protein kinase
ToN1_23560	COG0631	protein serine/threonine phosphatase activity
ToN1_23570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ToN1_23580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ToN1_23590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ToN1_23600	COG0616	signal peptide processing
ToN1_23610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ToN1_23620	COG2022	thiamine diphosphate biosynthetic process
ToN1_23640	COG2032	superoxide dismutase activity
ToN1_23660	COG0508	dehydrogenase complex catalyzes the overall conversion of
ToN1_23660	COG0022	dehydrogenase e1 component
ToN1_23670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ToN1_23690	COG1956	GAF domain-containing protein
ToN1_23710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ToN1_23780	COG2860	membrane
ToN1_23790	COG1970	mechanosensitive ion channel activity
ToN1_23800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ToN1_23810	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ToN1_23870	COG0840	transmembrane signaling receptor activity
ToN1_23890	COG4633	Protein conserved in bacteria
ToN1_23900	COG0672	)-iron permease
ToN1_23930	COG3383	formate dehydrogenase (NAD+) activity
ToN1_23960	COG0583	DNA-binding transcription factor activity
ToN1_24000	COG0840	transmembrane signaling receptor activity
ToN1_24030	COG1136	(ABC) transporter
ToN1_24090	COG3245	cytochrome
ToN1_24120	COG4566	intracellular signal transduction
ToN1_24200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ToN1_24210	COG0321	lipoyl(octanoyl) transferase activity
ToN1_24220	COG2921	Belongs to the UPF0250 family
ToN1_24240	COG1686	Belongs to the peptidase S11 family
ToN1_24260	COG0772	Belongs to the SEDS family
ToN1_24270	COG0768	penicillin binding
ToN1_24300	COG1077	Cell shape determining protein MreB Mrl
ToN1_24310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ToN1_24320	COG0154	amidase activity
ToN1_24340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ToN1_24350	COG0121	glutamine amidotransferase
ToN1_24380	COG0745	RESPONSE REGULATOR receiver
ToN1_24400	COG2226	methyltransferase
ToN1_24430	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ToN1_24440	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ToN1_24450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ToN1_24460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ToN1_24470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ToN1_24480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ToN1_24500	COG0356	it plays a direct role in the translocation of protons across the membrane
ToN1_24520	COG1475	DNA binding
ToN1_24530	COG1192	Involved in chromosome partitioning
ToN1_24540	COG0357	Ribosomal RNA small subunit methyltransferase G
ToN1_24550	COG0445	tRNA wobble uridine modification
ToN1_24570	COG2824	Alkylphosphonate utilization operon protein PhnA
ToN1_24580	COG1126	abc transporter atp-binding protein
ToN1_24590	COG0765	amino acid transport
ToN1_24600	COG0765	amino acid transport
ToN1_24610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ToN1_24630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ToN1_24640	COG2373	Large extracellular alpha-helical protein
ToN1_24650	COG4953	penicillin-binding protein 1C
ToN1_24700	COG0437	4 iron, 4 sulfur cluster binding
ToN1_24710	COG0243	molybdopterin cofactor binding
ToN1_24710	COG3383	formate dehydrogenase (NAD+) activity
ToN1_24770	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ToN1_24780	COG0746	molybdenum cofactor guanylyltransferase activity
ToN1_24800	COG1763	Mo-molybdopterin cofactor biosynthetic process
ToN1_24810	COG2204	response regulator
ToN1_24820	COG4191	Histidine kinase
ToN1_24830	COG0501	Belongs to the peptidase M48B family
ToN1_24840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ToN1_24850	COG0242	peptide deformylase activity
ToN1_24870	COG0758	DNA mediated transformation
ToN1_24880	COG2922	Belongs to the Smg family
ToN1_24890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ToN1_24890	COG0551	DNA topoisomerase type I activity
ToN1_24900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ToN1_24920	COG4206	TonB-dependent receptor
ToN1_24930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ToN1_24940	COG3909	cytochrome
ToN1_24970	COG0583	DNA-binding transcription factor activity
ToN1_25010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ToN1_25030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ToN1_25050	COG1187	pseudouridine synthase activity
ToN1_25070	COG2974	May be involved in recombination
ToN1_25090	COG0745	RESPONSE REGULATOR receiver
ToN1_25100	COG4251	negative regulation of phosphorylation
ToN1_25120	COG1960	acyl-CoA dehydrogenase activity
ToN1_25130	COG0583	DNA-binding transcription factor activity
ToN1_25140	COG3706	GGDEF domain
ToN1_25180	COG0686	Belongs to the AlaDH PNT family
ToN1_25240	COG3706	GGDEF domain
ToN1_25260	COG0655	NAD(P)H dehydrogenase (quinone) activity
ToN1_25320	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ToN1_25330	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ToN1_25340	COG0594	ribonuclease P activity
ToN1_25350	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ToN1_25360	COG0706	membrane insertase activity
ToN1_25370	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ToN1_25390	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ToN1_25420	COG5000	phosphorelay sensor kinase activity
ToN1_25430	COG2204	response regulator
ToN1_25440	COG0569	domain protein
ToN1_25460	COG0840	transmembrane signaling receptor activity
ToN1_25490	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ToN1_25550	COG3052	prosthetic group binding
ToN1_25560	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
ToN1_25620	COG3181	Tripartite tricarboxylate transporter family receptor
ToN1_25650	COG0861	Integral membrane protein TerC family
ToN1_25680	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ToN1_25690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ToN1_25700	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ToN1_25710	COG0437	4 iron, 4 sulfur cluster binding
ToN1_25720	COG5557	Pfam Polysulphide reductase, NrfD
ToN1_25730	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ToN1_25740	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ToN1_25790	COG0375	protein maturation
ToN1_25810	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ToN1_25820	COG0298	carbon dioxide binding
ToN1_25830	COG0409	Hydrogenase expression formation protein
ToN1_25840	COG0309	Hydrogenase expression formation protein (HypE)
ToN1_25850	COG1024	Enoyl-CoA hydratase
ToN1_25850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ToN1_25860	COG2204	response regulator
ToN1_25870	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ToN1_25950	COG2258	MOSC domain
ToN1_26050	COG1278	Cold shock
ToN1_26055	COG2329	Antibiotic biosynthesis monooxygenase
ToN1_26430	COG2814	Major facilitator Superfamily
ToN1_26470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ToN1_26520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ToN1_26530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ToN1_26540	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ToN1_26580	COG0488	(ABC) transporter
ToN1_26600	COG0826	peptidase U32
ToN1_26680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ToN1_26760	COG0411	ABC transporter
ToN1_26810	COG1773	rubredoxin
ToN1_26870	COG1960	acyl-CoA dehydrogenase activity
ToN1_26900	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ToN1_26920	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_26930	COG1024	Enoyl-CoA hydratase
ToN1_26940	COG1024	Enoyl-CoA hydratase
ToN1_26950	COG1309	transcriptional regulator
ToN1_26960	COG0500	methyltransferase
ToN1_26970	COG3001	Fructosamine kinase
ToN1_27020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ToN1_27050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ToN1_27170	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ToN1_27180	COG3842	ATPase activity
ToN1_27190	COG1176	ABC-type spermidine putrescine transport system, permease component I
ToN1_27200	COG1177	transmembrane transport
ToN1_27210	COG1132	(ABC) transporter
ToN1_27220	COG0628	permease
ToN1_27240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_27280	COG3204	pilus organization
ToN1_27300	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ToN1_27310	COG1074	ATP-dependent DNA helicase activity
ToN1_27320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ToN1_27330	COG4191	Histidine kinase
ToN1_27340	COG2204	response regulator
ToN1_27350	COG1459	type II secretion system
ToN1_27360	COG2165	general secretion pathway protein
ToN1_27430	COG4537	Required for transformation and DNA binding
ToN1_27450	COG1278	Cold shock
ToN1_27470	COG0330	HflC and HflK could
ToN1_27530	COG0477	Major facilitator Superfamily
ToN1_27550	COG1305	Transglutaminase-like
ToN1_27560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ToN1_27580	COG3045	CreA protein
ToN1_27600	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ToN1_27610	COG0484	heat shock protein binding
ToN1_27660	COG0194	GDP metabolic process
ToN1_27670	COG1758	RNA polymerase activity
ToN1_27680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ToN1_27690	COG0523	cobalamin synthesis protein
ToN1_27700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ToN1_27750	COG3850	Histidine kinase
ToN1_27760	COG2197	response regulator
ToN1_27790	COG0243	molybdopterin cofactor binding
ToN1_27800	COG0437	4 iron, 4 sulfur cluster binding
ToN1_27810	COG0348	domain, Protein
ToN1_27820	COG3043	anaerobic respiration
ToN1_27830	COG3005	denitrification pathway
ToN1_27840	COG4133	protoheme IX ABC transporter activity
ToN1_27850	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ToN1_27870	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ToN1_27880	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ToN1_27900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ToN1_27910	COG3088	subunit of a heme lyase
ToN1_27920	COG3088	subunit of a heme lyase
ToN1_27920	COG4235	cytochrome complex assembly
ToN1_27950	COG2010	Cytochrome c
ToN1_27970	COG2204	response regulator
ToN1_27980	COG4191	Histidine kinase
ToN1_28030	COG2132	Multicopper oxidase
ToN1_28040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ToN1_28050	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ToN1_28060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ToN1_28120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ToN1_28260	COG2010	Cytochrome c
ToN1_28350	COG1215	transferase activity, transferring glycosyl groups
ToN1_28370	COG0438	transferase activity, transferring glycosyl groups
ToN1_28440	COG0714	Associated with various cellular activities
ToN1_28490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ToN1_28550	COG1032	radical SAM domain protein
ToN1_28600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ToN1_28640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ToN1_28650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ToN1_28810	COG1024	Enoyl-CoA hydratase
ToN1_28820	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_28830	COG2050	protein possibly involved in aromatic compounds catabolism
ToN1_28850	COG3396	Phenylacetate-CoA oxygenase
ToN1_28860	COG3460	Phenylacetate-CoA oxygenase
ToN1_28870	COG3396	Phenylacetate-CoA oxygenase
ToN1_28880	COG2151	metal-sulfur cluster biosynthetic enzyme
ToN1_28890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ToN1_28970	COG0583	DNA-binding transcription factor activity
ToN1_28980	COG4191	Histidine kinase
ToN1_28990	COG4566	intracellular signal transduction
ToN1_29030	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ToN1_29070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ToN1_29110	COG0513	Belongs to the DEAD box helicase family
ToN1_29140	COG0596	Alpha beta hydrolase
ToN1_29150	COG5001	Diguanylate cyclase
ToN1_29150	COG3300	MHYT domain
ToN1_29170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ToN1_29180	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ToN1_29210	COG4232	protein-disulfide reductase activity
ToN1_29230	COG1324	tolerance protein
ToN1_29300	COG3279	Response regulator of the LytR AlgR family
ToN1_29320	COG2203	Gaf domain
ToN1_29320	COG3706	GGDEF domain
ToN1_29320	COG4251	negative regulation of phosphorylation
ToN1_29320	COG5001	Diguanylate cyclase
ToN1_29360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ToN1_29430	COG0861	Integral membrane protein TerC family
ToN1_29450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ToN1_29480	COG0348	domain, Protein
ToN1_29510	COG1131	(ABC) transporter
ToN1_29520	COG0625	glutathione transferase activity
ToN1_29560	COG3154	lipid carrier protein
ToN1_29570	COG0826	peptidase U32
ToN1_29580	COG0826	peptidase U32
ToN1_29620	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ToN1_29670	COG0346	lactoylglutathione lyase activity
ToN1_29710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ToN1_29720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ToN1_29730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ToN1_29740	COG0018	arginyl-trna synthetase
ToN1_29770	COG0300	oxidoreductase activity
ToN1_29780	COG2902	Dehydrogenase
ToN1_29800	COG0826	peptidase U32
ToN1_29820	COG3158	transport of potassium into the cell
ToN1_29830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ToN1_29850	COG3243	poly(R)-hydroxyalkanoic acid synthase
ToN1_29860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ToN1_29870	COG0789	Transcriptional regulator
ToN1_29880	COG0288	reversible hydration of carbon dioxide
ToN1_29890	COG0183	Belongs to the thiolase family
ToN1_29900	COG1960	acyl-CoA dehydrogenase activity
ToN1_29910	COG1024	Enoyl-CoA hydratase
ToN1_29950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ToN1_29960	COG1660	Displays ATPase and GTPase activities
ToN1_29990	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ToN1_30030	COG1301	dicarboxylic acid transport
ToN1_30050	COG1053	succinate dehydrogenase
ToN1_30060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ToN1_30110	COG0217	transcriptional regulatory protein
ToN1_30140	COG0433	COG0433 Predicted ATPase
ToN1_30190	COG4176	ABC-type proline glycine betaine transport system permease component
ToN1_30210	COG0546	phosphoglycolate phosphatase activity
ToN1_30210	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ToN1_30220	COG0277	FAD linked oxidase domain protein
ToN1_30230	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_30250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ToN1_30360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ToN1_30380	COG1278	Cold shock
ToN1_30390	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ToN1_30440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ToN1_30470	COG1560	Kdo2-lipid A biosynthetic process
ToN1_30480	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ToN1_30500	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ToN1_30520	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ToN1_30540	COG2255	four-way junction helicase activity
ToN1_30550	COG0632	four-way junction helicase activity
ToN1_30570	COG1530	ribonuclease E activity
ToN1_30580	COG0424	maF-like protein
ToN1_30620	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ToN1_30630	COG0799	negative regulation of ribosome biogenesis
ToN1_30640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ToN1_30670	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ToN1_30730	COG1115	amino acid carrier protein
ToN1_30740	COG2192	nodulation
ToN1_30750	COG0438	transferase activity, transferring glycosyl groups
ToN1_30820	COG1132	(ABC) transporter
ToN1_30830	COG1368	sulfuric ester hydrolase activity
ToN1_30880	COG0438	transferase activity, transferring glycosyl groups
ToN1_30890	COG0859	PFAM glycosyl transferase family 9
ToN1_30910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ToN1_30920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ToN1_30920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ToN1_30940	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ToN1_30950	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ToN1_30980	COG4206	TonB-dependent receptor
ToN1_31000	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ToN1_31020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ToN1_31020	COG1648	precorrin-2 dehydrogenase activity
ToN1_31040	COG2818	Glycosylase
ToN1_31050	COG0583	DNA-binding transcription factor activity
ToN1_31100	COG0247	lactate metabolic process
ToN1_31110	COG0697	spore germination
ToN1_31140	COG0583	DNA-binding transcription factor activity
ToN1_31150	COG1032	radical SAM domain protein
ToN1_31160	COG3023	N-Acetylmuramoyl-L-alanine amidase
ToN1_31170	COG0741	lytic transglycosylase activity
ToN1_31180	COG0436	Aminotransferase
ToN1_31190	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ToN1_31200	COG0280	phosphate acetyltransferase
ToN1_31200	COG0281	malic enzyme
ToN1_31240	COG1187	pseudouridine synthase activity
ToN1_31260	COG0577	efflux transmembrane transporter activity
ToN1_31260	COG1136	(ABC) transporter
ToN1_31280	COG0577	efflux transmembrane transporter activity
ToN1_31280	COG1136	(ABC) transporter
ToN1_31290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_31300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ToN1_31310	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ToN1_31320	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ToN1_31320	COG0493	'glutamate synthase
ToN1_31360	COG4269	membrane
ToN1_31370	COG0501	Belongs to the peptidase M48B family
ToN1_31380	COG1643	Atp-dependent helicase
ToN1_31390	COG0360	Binds together with S18 to 16S ribosomal RNA
ToN1_31400	COG2965	DNA replication, synthesis of RNA primer
ToN1_31410	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ToN1_31420	COG0359	binds to the 23S rRNA
ToN1_31430	COG0305	Participates in initiation and elongation during chromosome replication
ToN1_31450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ToN1_31460	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ToN1_31470	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ToN1_31500	COG0494	nUDIX hydrolase
ToN1_31510	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ToN1_31520	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ToN1_31530	COG0237	dephospho-CoA kinase activity
ToN1_31550	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
ToN1_31560	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ToN1_31590	COG3852	Histidine kinase
ToN1_31610	COG0174	glutamine synthetase
ToN1_31650	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ToN1_31660	COG3568	Endonuclease Exonuclease Phosphatase
ToN1_31670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ToN1_31700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ToN1_31740	COG0463	Glycosyl transferase, family 2
ToN1_31770	COG0564	pseudouridine synthase activity
ToN1_31780	COG0012	GTP binding
ToN1_31790	COG0193	aminoacyl-tRNA hydrolase activity
ToN1_31800	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ToN1_31810	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ToN1_31830	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ToN1_31840	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ToN1_31860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ToN1_31870	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ToN1_31880	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ToN1_31890	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ToN1_31900	COG0742	ribosomal rna small subunit methyltransferase
ToN1_31920	COG0612	Peptidase, M16
ToN1_31940	COG2884	Cell division ATP-binding protein ftsE
ToN1_31950	COG2177	Part of the ABC transporter FtsEX involved in
ToN1_31970	COG4191	Histidine kinase
ToN1_31970	COG0784	Response regulator, receiver
ToN1_31990	COG2084	Dehydrogenase
ToN1_32000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ToN1_32020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ToN1_32030	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_32040	COG3958	Transketolase
ToN1_32050	COG3959	Transketolase, thiamine diphosphate binding domain
ToN1_32060	COG0583	DNA-binding transcription factor activity
ToN1_32100	COG1607	acyl-coa hydrolase
ToN1_32110	COG2703	oxygen carrier activity
ToN1_32120	COG3622	Belongs to the hyi family
ToN1_32130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ToN1_32140	COG0251	oxidation-reduction process
ToN1_32150	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_32160	COG0183	Belongs to the thiolase family
ToN1_32190	COG1960	acyl-CoA dehydrogenase activity
ToN1_32200	COG1960	acyl-CoA dehydrogenase activity
ToN1_32210	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_32220	COG1053	succinate dehydrogenase
ToN1_32290	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_32300	COG4638	Rieske (2fe-2S)
ToN1_32310	COG0604	alcohol dehydrogenase
ToN1_32340	COG4447	cellulose binding
ToN1_32420	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ToN1_32430	COG0022	dehydrogenase e1 component
ToN1_32440	COG0508	dehydrogenase complex catalyzes the overall conversion of
ToN1_32450	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_32460	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_32490	COG1024	Enoyl-CoA hydratase
ToN1_32510	COG1309	transcriptional regulator
ToN1_32520	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_32540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ToN1_32550	COG1702	phosphate starvation-inducible protein PhoH
ToN1_32560	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ToN1_32570	COG4535	Mg2 and Co2 transporter CorC
ToN1_32580	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ToN1_32590	COG0752	glycyl-tRNA synthetase alpha subunit
ToN1_32600	COG0751	glycine-tRNA ligase activity
ToN1_32610	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ToN1_32620	COG0204	Acyl-transferase
ToN1_32680	COG1024	Enoyl-CoA hydratase
ToN1_32690	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ToN1_32730	COG1127	ABC transporter
ToN1_32740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ToN1_32750	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ToN1_32790	COG1131	(ABC) transporter
ToN1_32800	COG0842	Transport permease protein
ToN1_32820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ToN1_32830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ToN1_32840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ToN1_32850	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ToN1_32860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ToN1_32880	COG0131	Imidazoleglycerol-phosphate dehydratase
ToN1_32890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ToN1_32900	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ToN1_32910	COG0107	imidazoleglycerol-phosphate synthase activity
ToN1_32920	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ToN1_32930	COG0140	phosphoribosyl-ATP diphosphatase activity
ToN1_32950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ToN1_32960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ToN1_32970	COG0805	protein transport
ToN1_32990	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ToN1_33020	COG0045	succinate-CoA ligase (ADP-forming) activity
ToN1_33030	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ToN1_33040	COG3485	protocatechuate 3,4-dioxygenase
ToN1_33080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ToN1_33100	COG0306	phosphate transporter
ToN1_33140	COG0105	UTP biosynthetic process
ToN1_33150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ToN1_33170	COG1426	Protein conserved in bacteria
ToN1_33180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ToN1_33190	COG0124	histidyl-tRNA synthetase
ToN1_33200	COG2976	Protein conserved in bacteria
ToN1_33210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ToN1_33220	COG1160	GTP binding
ToN1_33230	COG1923	regulation of RNA biosynthetic process
ToN1_33240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ToN1_33250	COG0330	HflC and HflK could
ToN1_33260	COG0330	HflC and HflK could
ToN1_33280	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ToN1_33290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ToN1_33300	COG0557	exoribonuclease II activity
ToN1_33310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ToN1_33320	COG3707	response regulator
ToN1_33330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ToN1_33350	COG1116	anion transmembrane transporter activity
ToN1_33390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ToN1_33410	COG2223	nitrite transmembrane transporter activity
ToN1_33420	COG0515	serine threonine protein kinase
ToN1_33420	COG2815	serine threonine protein kinase
ToN1_33430	COG0243	molybdopterin cofactor binding
ToN1_33460	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ToN1_33470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ToN1_33480	COG2252	PERMEase
ToN1_33490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_33500	COG1752	Esterase of the alpha-beta hydrolase superfamily
ToN1_33510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ToN1_33540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ToN1_33550	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ToN1_33560	COG0723	plastoquinol--plastocyanin reductase activity
ToN1_33570	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ToN1_33580	COG2857	Cytochrome c1
ToN1_33590	COG0625	glutathione transferase activity
ToN1_33600	COG2969	positive regulation of protein catabolic process
ToN1_33610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ToN1_33620	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ToN1_33700	COG1595	DNA-templated transcription, initiation
ToN1_33740	COG3220	belongs to the UPF0276 family
ToN1_33760	COG1448	Aminotransferase
ToN1_33770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_33810	COG0679	Auxin Efflux Carrier
ToN1_33830	COG3437	response regulator, receiver
ToN1_33900	COG4566	intracellular signal transduction
ToN1_33910	COG3706	GGDEF domain
ToN1_33970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ToN1_33980	COG4191	Histidine kinase
ToN1_33990	COG1100	Small GTP-binding protein
ToN1_34020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ToN1_34030	COG0459	protein refolding
ToN1_34060	COG0642	Histidine kinase
ToN1_34070	COG3162	membrane
ToN1_34150	COG1111	helicase
ToN1_34150	COG1205	dead DEAH box helicase
ToN1_34190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ToN1_34220	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ToN1_34320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ToN1_34330	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ToN1_34340	COG2890	protein-(glutamine-N5) methyltransferase activity
ToN1_34350	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ToN1_34410	COG0165	Argininosuccinate lyase
ToN1_34430	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ToN1_34440	COG0181	hydroxymethylbilane synthase activity
ToN1_34460	COG2959	enzyme of heme biosynthesis
ToN1_34480	COG0408	coproporphyrinogen oxidase activity
ToN1_34490	COG0151	Belongs to the GarS family
ToN1_34510	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ToN1_34520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ToN1_34540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ToN1_34550	COG0006	proline dipeptidase activity
ToN1_34580	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ToN1_34590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ToN1_34600	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ToN1_34610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ToN1_34630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ToN1_34660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ToN1_34720	COG0489	protein tyrosine kinase activity
ToN1_34790	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ToN1_34810	COG1696	Membrane protein involved in D-alanine export
ToN1_34820	COG0438	transferase activity, transferring glycosyl groups
ToN1_34830	COG2244	polysaccharide biosynthetic process
ToN1_34840	COG2327	Polysaccharide pyruvyl transferase
ToN1_34860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ToN1_34900	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ToN1_34920	COG2885	chlorophyll binding
ToN1_34930	COG5001	Diguanylate cyclase
ToN1_34930	COG5002	protein histidine kinase activity
ToN1_35000	COG0778	Nitroreductase
ToN1_35010	COG0469	pyruvate kinase activity
ToN1_35050	COG0126	phosphoglycerate kinase activity
ToN1_35060	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ToN1_35070	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ToN1_35080	COG3954	Phosphoribulokinase
ToN1_35100	COG0483	inositol monophosphate 1-phosphatase activity
ToN1_35110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ToN1_35140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ToN1_35140	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ToN1_35150	COG5002	protein histidine kinase activity
ToN1_35150	COG5001	Diguanylate cyclase
ToN1_35150	COG3447	MASE1 domain protein
ToN1_35160	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ToN1_35180	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ToN1_35190	COG0303	'Molybdopterin
ToN1_35220	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ToN1_35240	COG0546	phosphoglycolate phosphatase activity
ToN1_35250	COG2226	methyltransferase
ToN1_35260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ToN1_35270	COG1040	competence protein
ToN1_35280	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ToN1_35290	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ToN1_35310	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ToN1_35330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ToN1_35340	COG0640	Transcriptional regulator
ToN1_35350	COG0588	phosphoglycerate mutase activity
ToN1_35370	COG0793	Belongs to the peptidase S41A family
ToN1_35400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ToN1_35400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ToN1_35410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ToN1_35420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ToN1_35440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ToN1_35460	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ToN1_35470	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ToN1_35480	COG0312	modulator of DNA gyrase
ToN1_35490	COG3028	Belongs to the UPF0307 family
ToN1_35500	COG0521	Mo-molybdopterin cofactor biosynthetic process
ToN1_35510	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ToN1_35520	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ToN1_35550	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ToN1_35560	COG2096	Adenosyltransferase
ToN1_35580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ToN1_35660	COG0482	sulfurtransferase activity
ToN1_35710	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ToN1_35740	COG0312	modulator of DNA gyrase
ToN1_35760	COG2204	response regulator
ToN1_35780	COG2205	protein histidine kinase activity
ToN1_35810	COG0741	lytic transglycosylase activity
ToN1_35820	COG0442	prolyl-tRNA aminoacylation
ToN1_35840	COG0494	nUDIX hydrolase
ToN1_35860	COG1592	Rubrerythrin
ToN1_35870	COG0247	lactate metabolic process
ToN1_35900	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ToN1_35910	COG1765	OsmC-like protein
ToN1_35920	COG3033	Beta-eliminating lyase
ToN1_35940	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ToN1_35950	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ToN1_35960	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ToN1_35970	COG0316	Belongs to the HesB IscA family
ToN1_35980	COG0741	lytic transglycosylase activity
ToN1_35980	COG1196	nuclear chromosome segregation
ToN1_35980	COG0739	heme binding
ToN1_35990	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ToN1_36060	COG0010	Belongs to the arginase family
ToN1_36070	COG1228	amidohydrolase
ToN1_36090	COG2423	ornithine cyclodeaminase activity
ToN1_36100	COG0583	DNA-binding transcription factor activity
ToN1_36200	COG1960	acyl-CoA dehydrogenase activity
ToN1_36210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ToN1_36220	COG4770	biotin carboxylase activity
ToN1_36230	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_36250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_36260	COG0402	S-adenosylhomocysteine deaminase activity
ToN1_36320	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ToN1_36350	COG2201	protein-glutamate methylesterase activity
ToN1_36360	COG0784	Response regulator, receiver
ToN1_36360	COG0835	chemotaxis
ToN1_36370	COG0784	Response regulator, receiver
ToN1_36370	COG0835	chemotaxis
ToN1_36380	COG0745	RESPONSE REGULATOR receiver
ToN1_36390	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ToN1_36400	COG0784	Response regulator, receiver
ToN1_36400	COG2198	Histidine kinase
ToN1_36400	COG0643	Histidine kinase
ToN1_36430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ToN1_36440	COG0583	DNA-binding transcription factor activity
ToN1_36450	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ToN1_36460	COG4208	sulfate ABC transporter
ToN1_36470	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ToN1_36490	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ToN1_36500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ToN1_36510	COG1570	exodeoxyribonuclease VII activity
ToN1_36530	COG0811	peptide transport
ToN1_36540	COG0848	biopolymer transport protein
ToN1_36550	COG1663	tetraacyldisaccharide 4'-kinase activity
ToN1_36560	COG2835	tetraacyldisaccharide 4'-kinase activity
ToN1_36570	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ToN1_36580	COG0563	adenylate kinase activity
ToN1_36590	COG0205	6-phosphofructokinase activity
ToN1_36610	COG1881	PFAM PEBP family protein
ToN1_36630	COG0268	Binds directly to 16S ribosomal RNA
ToN1_36650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ToN1_36660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ToN1_36670	COG0137	argininosuccinate synthase activity
ToN1_36690	COG3123	guanosine phosphorylase activity
ToN1_36700	COG1666	GTP binding
ToN1_36720	COG4968	Prepilin-type N-terminal cleavage methylation domain
ToN1_36790	COG0745	RESPONSE REGULATOR receiver
ToN1_36790	COG2972	Histidine kinase
ToN1_36810	COG0494	nUDIX hydrolase
ToN1_36830	COG2217	Heavy metal translocating P-type atpase
ToN1_36860	COG3278	Belongs to the heme-copper respiratory oxidase family
ToN1_36900	COG0348	domain, Protein
ToN1_36940	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ToN1_36950	COG3243	poly(R)-hydroxyalkanoic acid synthase
ToN1_37000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ToN1_37010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ToN1_37040	COG2217	Heavy metal translocating P-type atpase
ToN1_37070	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ToN1_37090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ToN1_37090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ToN1_37110	COG2840	Smr protein MutS2
ToN1_37120	COG0492	ferredoxin-NADP+ reductase activity
ToN1_37150	COG1674	ftsk spoiiie
ToN1_37160	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ToN1_37170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ToN1_37190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ToN1_37200	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ToN1_37270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ToN1_37280	COG2951	lytic endotransglycosylase activity
ToN1_37310	COG0564	pseudouridine synthase activity
ToN1_37340	COG3243	poly(R)-hydroxyalkanoic acid synthase
ToN1_37350	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_37380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ToN1_37390	COG1752	Esterase of the alpha-beta hydrolase superfamily
ToN1_37400	COG0277	FAD linked oxidase domain protein
ToN1_37410	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_37420	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ToN1_37440	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ToN1_37450	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ToN1_37450	COG0517	IMP dehydrogenase activity
ToN1_37450	COG0617	tRNA 3'-terminal CCA addition
ToN1_37460	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_37480	COG0028	Belongs to the TPP enzyme family
ToN1_37490	COG0440	acetolactate synthase activity
ToN1_37510	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ToN1_37520	COG2814	Major facilitator Superfamily
ToN1_37540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ToN1_37550	COG0066	3-isopropylmalate dehydratase activity
ToN1_37560	COG0473	3-isopropylmalate dehydrogenase activity
ToN1_37600	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ToN1_37620	COG0101	tRNA pseudouridine synthase activity
ToN1_37630	COG0135	phosphoribosylanthranilate isomerase activity
ToN1_37640	COG0133	tryptophan synthase activity
ToN1_37650	COG0159	tryptophan synthase activity
ToN1_37660	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ToN1_37670	COG0285	dihydrofolate synthase activity
ToN1_37720	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ToN1_37730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ToN1_37770	COG0215	cysteine-tRNA ligase activity
ToN1_37780	COG0484	heat shock protein binding
ToN1_37790	COG0443	Heat shock 70 kDa protein
ToN1_37800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ToN1_37810	COG0515	serine threonine protein kinase
ToN1_37810	COG2815	serine threonine protein kinase
ToN1_37840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ToN1_37850	COG1420	regulation of RNA biosynthetic process
ToN1_37860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ToN1_37870	COG0497	DNA recombination
ToN1_37880	COG0735	belongs to the Fur family
ToN1_37890	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ToN1_37900	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ToN1_37910	COG0505	Belongs to the CarA family
ToN1_37920	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ToN1_37930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ToN1_37950	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ToN1_37960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ToN1_37980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ToN1_37990	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ToN1_38000	COG0573	inorganic phosphate transmembrane transporter activity
ToN1_38010	COG0573	inorganic phosphate transmembrane transporter activity
ToN1_38020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ToN1_38030	COG0149	triose-phosphate isomerase activity
ToN1_38050	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ToN1_38060	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ToN1_38070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ToN1_38080	COG0649	NAD binding
ToN1_38090	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ToN1_38110	COG1034	ATP synthesis coupled electron transport
ToN1_38120	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ToN1_38130	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ToN1_38150	COG0713	ATP synthesis coupled electron transport
ToN1_38180	COG1007	ATP synthesis coupled electron transport
ToN1_38200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ToN1_38210	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ToN1_38220	COG3383	formate dehydrogenase (NAD+) activity
ToN1_38230	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
ToN1_38240	COG3259	Nickel-dependent hydrogenase
ToN1_38330	COG3193	protein, possibly involved in utilization of glycolate and propanediol
ToN1_38410	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_38460	COG1132	(ABC) transporter
ToN1_38500	COG1027	Aspartate ammonia-lyase
ToN1_38610	COG1490	D-aminoacyl-tRNA deacylase activity
ToN1_38650	COG3384	dioxygenase
ToN1_38660	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ToN1_38670	COG0183	Belongs to the thiolase family
ToN1_38680	COG1162	GTPase activity
ToN1_38690	COG0501	Belongs to the peptidase M48B family
ToN1_38700	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ToN1_38720	COG0254	rRNA binding
ToN1_38740	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ToN1_38750	COG3012	SEC-C Motif Domain Protein
ToN1_38750	COG3318	Belongs to the UPF0149 family
ToN1_38820	COG3012	SEC-C Motif Domain Protein
ToN1_38830	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ToN1_38860	COG0668	transmembrane transport
ToN1_38870	COG1363	Peptidase, m42
ToN1_38890	COG0367	asparagine synthase
ToN1_38900	COG0791	NLP P60 protein
ToN1_38930	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ToN1_38940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ToN1_38960	COG0436	Aminotransferase
ToN1_39000	COG0697	spore germination
ToN1_39020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ToN1_39020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ToN1_39040	COG2719	SpoVR family
ToN1_39060	COG2766	serine protein kinase
ToN1_39070	COG0544	peptidyl-prolyl cis-trans isomerase activity
ToN1_39080	COG0740	serine-type endopeptidase activity
ToN1_39090	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ToN1_39100	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ToN1_39140	COG0242	peptide deformylase activity
ToN1_39150	COG1595	DNA-templated transcription, initiation
ToN1_39170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_39180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ToN1_39210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_39240	COG2204	response regulator
ToN1_39380	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_39430	COG4628	conserved protein (DUF2132)
ToN1_39450	COG0674	pyruvate-flavodoxin oxidoreductase activity
ToN1_39450	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ToN1_39460	COG1013	pyruvate-flavodoxin oxidoreductase activity
ToN1_39470	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ToN1_39490	COG2814	Major facilitator Superfamily
ToN1_39500	COG3327	negative regulation of DNA-templated transcription, initiation
ToN1_39520	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ToN1_39530	COG0243	molybdopterin cofactor binding
ToN1_39660	COG2153	protein acetylation
ToN1_39700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ToN1_39710	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ToN1_39740	COG0084	hydrolase, TatD family'
ToN1_39830	COG1558	bacterial-type flagellum-dependent cell motility
ToN1_39840	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ToN1_39880	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ToN1_39890	COG1706	bacterial-type flagellum-dependent cell motility
ToN1_39940	COG1684	flagellar biosynthetic protein fliR
ToN1_39960	COG1338	Plays a role in the flagellum-specific transport system
ToN1_39990	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ToN1_40030	COG1157	protein secretion by the type III secretion system
ToN1_40060	COG1766	The M ring may be actively involved in energy transduction
ToN1_40090	COG1677	Flagellar hook-basal body complex protein FliE
ToN1_40100	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ToN1_40110	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ToN1_40150	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ToN1_40160	COG1334	flagellar protein FlaG
ToN1_40200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ToN1_40210	COG0508	dehydrogenase complex catalyzes the overall conversion of
ToN1_40220	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ToN1_40250	COG4566	intracellular signal transduction
ToN1_40270	COG0840	transmembrane signaling receptor activity
ToN1_40300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ToN1_40310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ToN1_40320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ToN1_40330	COG0009	L-threonylcarbamoyladenylate synthase
ToN1_40400	COG2801	Transposase and inactivated derivatives
ToN1_40510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ToN1_40510	COG1199	ATP-dependent helicase activity
ToN1_40530	COG4303	Ethanolamine ammonia lyase large subunit
ToN1_40570	COG2814	Major facilitator Superfamily
ToN1_40580	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ToN1_40590	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ToN1_40600	COG0583	DNA-binding transcription factor activity
ToN1_40610	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_40650	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ToN1_40650	COG1796	DNA polymerase
ToN1_40660	COG0459	protein refolding
ToN1_40700	COG0484	heat shock protein binding
ToN1_40720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_40730	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ToN1_40740	COG0022	dehydrogenase e1 component
ToN1_40740	COG0508	dehydrogenase complex catalyzes the overall conversion of
ToN1_40770	COG0668	transmembrane transport
ToN1_40870	COG4772	TonB-dependent receptor
ToN1_40890	COG1944	ATP diphosphatase activity
ToN1_40910	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ToN1_40950	COG0386	Belongs to the glutathione peroxidase family
ToN1_41120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ToN1_41180	COG3138	arginine N-succinyltransferase
ToN1_41200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ToN1_41230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ToN1_41230	COG2111	Na H antiporter
ToN1_41240	COG1006	Multisubunit Na H antiporter MnhC subunit
ToN1_41250	COG0651	ATP synthesis coupled electron transport
ToN1_41260	COG1863	multisubunit Na H antiporter MnhE subunit
ToN1_41270	COG2212	antiporter activity
ToN1_41280	COG1320	monovalent cation:proton antiporter activity
ToN1_41290	COG0583	DNA-binding transcription factor activity
ToN1_41340	COG1509	lysine 2,3-aminomutase activity
ToN1_41350	COG0604	alcohol dehydrogenase
ToN1_41370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ToN1_41380	COG5012	cobalamin binding
ToN1_41390	COG1607	acyl-coa hydrolase
ToN1_41400	COG3246	L-lysine catabolic process to acetate
ToN1_41470	COG0459	protein refolding
ToN1_41480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ToN1_41540	COG0010	Belongs to the arginase family
ToN1_41560	COG5006	permease, DMT superfamily
ToN1_41570	COG3284	Transcriptional regulator
ToN1_41580	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_41600	COG3284	Transcriptional regulator
ToN1_41610	COG2197	response regulator
ToN1_41620	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_41710	COG1131	(ABC) transporter
ToN1_41780	COG3284	Transcriptional regulator
ToN1_41800	COG2414	aldehyde ferredoxin oxidoreductase
ToN1_41810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ToN1_41850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ToN1_41860	COG0583	DNA-binding transcription factor activity
ToN1_41880	COG3038	cytochrome b561
ToN1_41890	COG2353	YceI-like domain
ToN1_41900	COG2353	YceI-like domain
ToN1_41970	COG0315	cyclic pyranopterin monophosphate synthase activity
ToN1_42000	COG0425	Belongs to the sulfur carrier protein TusA family
ToN1_42010	COG0525	valine-tRNA ligase activity
ToN1_42040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ToN1_42050	COG0795	lipopolysaccharide-transporting ATPase activity
ToN1_42090	COG1959	2 iron, 2 sulfur cluster binding
ToN1_42110	COG2814	Major facilitator Superfamily
ToN1_42120	COG0583	DNA-binding transcription factor activity
ToN1_42130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ToN1_42140	COG0564	pseudouridine synthase activity
ToN1_42180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ToN1_42210	COG0798	PFAM Bile acid sodium symporter
ToN1_42220	COG2204	response regulator
ToN1_42230	COG4191	Histidine kinase
ToN1_42270	COG0243	molybdopterin cofactor binding
ToN1_42430	COG1473	amidohydrolase
ToN1_42440	COG0583	DNA-binding transcription factor activity
ToN1_42450	COG0583	DNA-binding transcription factor activity
ToN1_42460	COG0509	glycine decarboxylation via glycine cleavage system
ToN1_42480	COG2716	regulation of RNA biosynthetic process
ToN1_42500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ToN1_42510	COG1113	amino acid transport
ToN1_42520	COG1760	l-serine dehydratase
ToN1_42530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ToN1_42540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ToN1_42560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ToN1_42570	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ToN1_42580	COG0604	alcohol dehydrogenase
ToN1_42590	COG1671	Belongs to the UPF0178 family
ToN1_42600	COG3048	D-serine ammonia-lyase activity
ToN1_42650	COG4657	Part of a membrane complex involved in electron transport
ToN1_42660	COG2878	Part of a membrane complex involved in electron transport
ToN1_42670	COG4656	Part of a membrane complex involved in electron transport
ToN1_42690	COG4659	FMN binding
ToN1_42710	COG2914	Belongs to the UPF0125 (RnfH) family
ToN1_42785	COG2072	flavoprotein involved in K transport
ToN1_42790	COG0625	glutathione transferase activity
ToN1_42810	COG0589	response to stress
ToN1_42830	COG0494	nUDIX hydrolase
ToN1_42840	COG1011	Hydrolase
ToN1_42850	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ToN1_43010	COG0583	DNA-binding transcription factor activity
ToN1_43020	COG1295	ribonuclease BN
ToN1_43040	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ToN1_43060	COG0583	DNA-binding transcription factor activity
ToN1_43110	COG1122	ATPase activity
ToN1_43230	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ToN1_43230	COG0674	pyruvate-flavodoxin oxidoreductase activity
ToN1_43240	COG1013	pyruvate-flavodoxin oxidoreductase activity
ToN1_43250	COG0179	Fumarylacetoacetate (FAA) hydrolase
ToN1_43280	COG2271	Major facilitator Superfamily
ToN1_43360	COG0513	Belongs to the DEAD box helicase family
ToN1_43370	COG1451	nucleotide metabolic process
ToN1_43380	COG1024	Enoyl-CoA hydratase
ToN1_43390	COG0346	lactoylglutathione lyase activity
ToN1_43410	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ToN1_43420	COG0148	phosphopyruvate hydratase activity
ToN1_43430	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_43460	COG2017	converts alpha-aldose to the beta-anomer
ToN1_43470	COG0800	Aldolase
ToN1_43500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ToN1_43520	COG1737	Transcriptional regulator
ToN1_43530	COG0166	Belongs to the GPI family
ToN1_43570	COG2207	Transcriptional regulator
ToN1_43600	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ToN1_43610	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
ToN1_43630	COG0535	radical SAM domain protein
ToN1_43650	COG2259	Doxx family
ToN1_43660	COG3284	Transcriptional regulator
ToN1_43690	COG0095	Lipoate-protein ligase
ToN1_43720	COG0022	dehydrogenase e1 component
ToN1_43730	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ToN1_43770	COG1879	ABC-type sugar transport system periplasmic component
ToN1_43780	COG1172	Belongs to the binding-protein-dependent transport system permease family
ToN1_43820	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ToN1_43860	COG1902	pentaerythritol trinitrate reductase activity
ToN1_43910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ToN1_43950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_43960	COG0837	glucose binding
ToN1_43970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ToN1_44010	COG4977	sequence-specific DNA binding
ToN1_44010	COG1917	Cupin 2, conserved barrel domain protein
ToN1_44030	COG0673	inositol 2-dehydrogenase activity
ToN1_44080	COG0366	Alpha amylase catalytic
ToN1_44090	COG1653	transport
ToN1_44160	COG3437	response regulator, receiver
ToN1_44160	COG2770	Histidine kinase
ToN1_44250	COG2010	Cytochrome c
ToN1_44310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_44330	COG5002	protein histidine kinase activity
ToN1_44340	COG0745	RESPONSE REGULATOR receiver
ToN1_44350	COG2176	DNA-directed DNA polymerase activity
ToN1_44350	COG5002	protein histidine kinase activity
ToN1_44360	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ToN1_44380	COG5598	trimethylamine methyltransferase
ToN1_44390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ToN1_44430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ToN1_44490	COG0446	pyridine nucleotide-disulphide oxidoreductase
ToN1_44490	COG1902	pentaerythritol trinitrate reductase activity
ToN1_44500	COG2181	nitrate reductase activity
ToN1_44500	COG0247	lactate metabolic process
ToN1_44510	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ToN1_44540	COG2113	Glycine betaine
ToN1_44650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ToN1_44690	COG0583	DNA-binding transcription factor activity
ToN1_44710	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_44760	COG0543	2 iron, 2 sulfur cluster binding
ToN1_44760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ToN1_44780	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ToN1_44790	COG3383	formate dehydrogenase (NAD+) activity
ToN1_44880	COG4175	Glycine betaine
ToN1_44900	COG1309	transcriptional regulator
ToN1_44920	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ToN1_44940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ToN1_44950	COG0285	dihydrofolate synthase activity
ToN1_44960	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ToN1_44980	COG5012	cobalamin binding
ToN1_45050	COG5012	cobalamin binding
ToN1_45060	COG0646	methionine synthase
ToN1_45060	COG1410	methionine synthase
ToN1_45080	COG1469	GTP cyclohydrolase I activity
ToN1_45110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ToN1_45120	COG1760	l-serine dehydratase
ToN1_45180	COG2223	nitrite transmembrane transporter activity
ToN1_45240	COG2885	chlorophyll binding
ToN1_45280	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ToN1_45290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ToN1_45320	COG2009	succinate dehydrogenase
ToN1_45340	COG2200	EAL domain
ToN1_45340	COG2202	Pas domain
ToN1_45340	COG2199	diguanylate cyclase activity
ToN1_45400	COG1611	Belongs to the LOG family
ToN1_45430	COG2353	YceI-like domain
ToN1_45470	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ToN1_45490	COG4208	sulfate ABC transporter
ToN1_45500	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ToN1_45510	COG0530	calcium, potassium:sodium antiporter activity
ToN1_45540	COG0446	pyridine nucleotide-disulphide oxidoreductase
ToN1_45550	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ToN1_45570	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ToN1_45580	COG2078	PFAM AMMECR1 domain protein
ToN1_45590	COG1355	regulation of microtubule-based process
ToN1_45610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ToN1_45620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ToN1_45690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ToN1_45710	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ToN1_45720	COG0248	Ppx GppA phosphatase
ToN1_45730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ToN1_45740	COG1127	ABC transporter
ToN1_45780	COG0084	hydrolase, TatD family'
ToN1_45790	COG1309	transcriptional regulator
ToN1_45820	COG1960	acyl-CoA dehydrogenase activity
ToN1_45830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ToN1_45840	COG0271	Belongs to the BolA IbaG family
ToN1_45850	COG2350	Protein conserved in bacteria
ToN1_45860	COG2917	probably involved in intracellular septation
ToN1_45900	COG1214	PFAM Peptidase M22, glycoprotease
ToN1_45920	COG1573	uracil-dna glycosylase
ToN1_45930	COG0477	Major facilitator Superfamily
ToN1_45950	COG0583	DNA-binding transcription factor activity
ToN1_45970	COG1309	transcriptional regulator
ToN1_45980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_46000	COG0577	efflux transmembrane transporter activity
ToN1_46000	COG1136	(ABC) transporter
ToN1_46010	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ToN1_46030	COG2195	Cleaves the N-terminal amino acid of tripeptides
ToN1_46040	COG3530	Putative quorum-sensing-regulated virulence factor
ToN1_46050	COG2169	Transcriptional regulator
ToN1_46050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ToN1_46060	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ToN1_46080	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ToN1_46090	COG1127	ABC transporter
ToN1_46120	COG1846	Transcriptional regulator
ToN1_46170	COG1620	l-lactate permease
ToN1_46190	COG1136	(ABC) transporter
ToN1_46240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ToN1_46260	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ToN1_46290	COG0446	pyridine nucleotide-disulphide oxidoreductase
ToN1_46290	COG1902	pentaerythritol trinitrate reductase activity
ToN1_46310	COG0739	heme binding
ToN1_46310	COG0741	lytic transglycosylase activity
ToN1_46310	COG1196	nuclear chromosome segregation
ToN1_46340	COG0671	phosphoesterase, PA-phosphatase related
ToN1_46360	COG0463	Glycosyl transferase, family 2
ToN1_46380	COG0671	phosphoesterase, PA-phosphatase related
ToN1_46390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ToN1_46390	COG0047	phosphoribosylformylglycinamidine synthase activity
ToN1_46490	COG0504	CTP synthase activity
ToN1_46500	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ToN1_46510	COG0148	phosphopyruvate hydratase activity
ToN1_46520	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ToN1_46540	COG0791	NLP P60 protein
ToN1_46590	COG5654	RES domain protein
ToN1_46620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ToN1_46680	COG1942	4-Oxalocrotonate Tautomerase
ToN1_46690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ToN1_46700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ToN1_46720	COG1024	Enoyl-CoA hydratase
ToN1_46730	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_46750	COG1846	Transcriptional regulator
ToN1_46770	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ToN1_46780	COG1960	acyl-CoA dehydrogenase activity
ToN1_46830	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_46840	COG0183	Belongs to the thiolase family
ToN1_46890	COG1522	sequence-specific DNA binding
ToN1_46900	COG3108	Peptidase M15
ToN1_46910	COG2989	Protein conserved in bacteria
ToN1_46920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_46930	COG0842	Transport permease protein
ToN1_46930	COG1129	ABC transporter
ToN1_46940	COG0842	Transport permease protein
ToN1_47050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ToN1_47050	COG1042	CoA-binding domain protein
ToN1_47050	COG0045	succinate-CoA ligase (ADP-forming) activity
ToN1_47060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ToN1_47080	COG1902	pentaerythritol trinitrate reductase activity
ToN1_47140	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_47170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ToN1_47220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ToN1_47270	COG0326	Molecular chaperone. Has ATPase activity
ToN1_47330	COG4251	negative regulation of phosphorylation
ToN1_47350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ToN1_47360	COG4660	Part of a membrane complex involved in electron transport
ToN1_47380	COG4658	electron transport chain
ToN1_47390	COG4656	Part of a membrane complex involved in electron transport
ToN1_47400	COG2878	Part of a membrane complex involved in electron transport
ToN1_47410	COG4657	Part of a membrane complex involved in electron transport
ToN1_47420	COG0167	dihydroorotate dehydrogenase activity
ToN1_47430	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ToN1_47440	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ToN1_47450	COG3842	ATPase activity
ToN1_47460	COG1178	ABC-type Fe3 transport system permease component
ToN1_47490	COG1840	ABC-type Fe3 transport system, periplasmic component
ToN1_47540	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ToN1_47560	COG0039	L-malate dehydrogenase activity
ToN1_47570	COG2188	Transcriptional regulator
ToN1_47600	COG1053	succinate dehydrogenase
ToN1_47610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ToN1_47620	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ToN1_47630	COG0372	Belongs to the citrate synthase family
ToN1_47640	COG0567	Dehydrogenase, E1 component
ToN1_47650	COG0508	dehydrogenase complex catalyzes the overall conversion of
ToN1_47660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ToN1_47670	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ToN1_47680	COG1199	ATP-dependent helicase activity
ToN1_47700	COG1763	Mo-molybdopterin cofactor biosynthetic process
ToN1_47710	COG0303	'Molybdopterin
ToN1_47720	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ToN1_47730	COG0314	molybdopterin synthase activity
ToN1_47750	COG0542	response to heat
ToN1_47790	COG0601	transmembrane transport
ToN1_47800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ToN1_47810	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ToN1_47820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ToN1_47840	COG2914	Belongs to the UPF0125 (RnfH) family
ToN1_47870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ToN1_47870	COG0519	Catalyzes the synthesis of GMP from XMP
ToN1_47880	COG1280	lysine exporter protein (LysE YggA)
ToN1_47890	COG1196	nuclear chromosome segregation
ToN1_47920	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ToN1_47930	COG3047	cAMP biosynthetic process
ToN1_48030	COG3706	GGDEF domain
ToN1_48140	COG0776	regulation of translation
ToN1_48150	COG2944	sequence-specific DNA binding
ToN1_48230	COG4566	intracellular signal transduction
ToN1_48290	COG4566	intracellular signal transduction
ToN1_48310	COG5002	protein histidine kinase activity
ToN1_48340	COG2204	response regulator
ToN1_48350	COG1100	Small GTP-binding protein
ToN1_48360	COG4191	Histidine kinase
ToN1_48360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ToN1_48370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ToN1_48390	COG4251	negative regulation of phosphorylation
ToN1_48430	COG4566	intracellular signal transduction
ToN1_48460	COG0784	Response regulator, receiver
ToN1_48460	COG2205	protein histidine kinase activity
ToN1_48460	COG5002	protein histidine kinase activity
ToN1_48480	COG2205	protein histidine kinase activity
ToN1_48480	COG5002	protein histidine kinase activity
ToN1_48480	COG0784	Response regulator, receiver
ToN1_48520	COG0776	regulation of translation
ToN1_48550	COG2010	Cytochrome c
ToN1_48570	COG4372	Transposase
ToN1_48580	COG3436	PFAM IS66 Orf2 family protein
ToN1_48680	COG5001	Diguanylate cyclase
ToN1_48680	COG5002	protein histidine kinase activity
ToN1_48750	COG0326	Molecular chaperone. Has ATPase activity
ToN1_48820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ToN1_48830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ToN1_48840	COG0450	alkyl hydroperoxide reductase
ToN1_48890	COG2363	Small membrane protein
ToN1_48900	COG2814	Major facilitator Superfamily
ToN1_48920	COG0411	ABC transporter
ToN1_48970	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_48980	COG1024	Enoyl-CoA hydratase
ToN1_49110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ToN1_49140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ToN1_49200	COG2133	pyrroloquinoline quinone binding
ToN1_49340	COG1966	Carbon starvation protein
ToN1_49350	COG2879	small protein
ToN1_49360	COG0523	cobalamin synthesis protein
ToN1_49380	COG0784	Response regulator, receiver
ToN1_49380	COG2205	protein histidine kinase activity
ToN1_49410	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ToN1_49420	COG0477	Major facilitator Superfamily
ToN1_49440	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ToN1_49480	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_49490	COG1253	flavin adenine dinucleotide binding
ToN1_49510	COG4681	YaeQ
ToN1_49560	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ToN1_49580	COG0302	gtp cyclohydrolase
ToN1_49600	COG0306	phosphate transporter
ToN1_49620	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ToN1_49710	COG1115	amino acid carrier protein
ToN1_49720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_49890	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ToN1_49940	COG1760	l-serine dehydratase
ToN1_49950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ToN1_49980	COG2271	Major facilitator Superfamily
ToN1_49990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ToN1_50000	COG0583	DNA-binding transcription factor activity
ToN1_50100	COG1757	Na H antiporter
ToN1_50110	COG2169	Transcriptional regulator
ToN1_50110	COG1917	Cupin 2, conserved barrel domain protein
ToN1_50150	COG0251	oxidation-reduction process
ToN1_50160	COG0477	Major facilitator Superfamily
ToN1_50190	COG1177	transmembrane transport
ToN1_50200	COG1176	ABC-type spermidine putrescine transport system, permease component I
ToN1_50230	COG3842	ATPase activity
ToN1_50300	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_50330	COG1802	Transcriptional regulator
ToN1_50340	COG0183	Belongs to the thiolase family
ToN1_50380	COG1960	acyl-CoA dehydrogenase activity
ToN1_50400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ToN1_50400	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ToN1_50440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_50510	COG1024	Enoyl-CoA hydratase
ToN1_50560	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ToN1_50590	COG0154	amidase activity