locus-tag class description ADJ73_00010 ENOG4105DR5 peptidase ADJ73_00020 ENOG4105C38 Glycyl-tRNA synthetase beta subunit ADJ73_00030 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein ADJ73_00115 ENOG4105WH1 Two component transcriptional regulator luxr family ADJ73_00135 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ADJ73_00140 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ADJ73_00145 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) ADJ73_00175 ENOG4105C1Q protoporphyrinogen oxidase ADJ73_00190 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ADJ73_00210 ENOG4105C26 Dehydrogenase ADJ73_00220 ENOG4105XT2 Transcriptional regulator ADJ73_00225 ENOG4107QVP Dehydrogenase ADJ73_00230 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ADJ73_00240 ENOG4108MMM RNA Polymerase ADJ73_00255 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) ADJ73_00260 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ADJ73_00265 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) ADJ73_00275 ENOG4108RVA ribokinase ADJ73_00280 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ADJ73_00285 ENOG4105KEG ribosomal-protein-alanine acetyltransferase ADJ73_00305 ENOG4108097 ATP-binding protein ADJ73_00315 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ADJ73_00325 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) ADJ73_00330 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ADJ73_00335 ENOG4105CS9 pantothenic acid kinase ADJ73_00350 ENOG4105CE1 Ferrous iron transport protein b ADJ73_00360 ENOG4108IAB Phoh family ADJ73_00365 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) ADJ73_00385 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) ADJ73_00400 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) ADJ73_00440 ENOG4105CHU acetyl-coa acetyltransferase ADJ73_00460 ENOG4107QP8 phosphohexose isomerase ADJ73_00465 ENOG4105C0F tryptophanase EC 4.1.99.1 ADJ73_00495 ENOG4107XKF NMT1 THI5 Like Domain Protein ADJ73_00500 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component ADJ73_00520 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) ADJ73_00545 ENOG41083GN tRNA synthetase class II (g h p and s) ADJ73_00550 ENOG4105C1G acyl-Coa dehydrogenase ADJ73_00555 ENOG410609C Acyl carrier protein ADJ73_00565 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) ADJ73_00570 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) ADJ73_00575 ENOG4105C6Y Udp-glucose 6-dehydrogenase ADJ73_00580 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) ADJ73_00585 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) ADJ73_00595 ENOG4105C5T Phosphoribosyl pyrophosphate synthase ADJ73_00600 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) ADJ73_00620 ENOG4107HP6 Transcriptional regulator ADJ73_00625 ENOG4108ZT1 Transcriptional regulator ADJ73_00640 ENOG4105C5H ABC transporter ADJ73_00645 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) ADJ73_00650 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) ADJ73_00655 ENOG4105F8V Hydrolase, tatD family ADJ73_00660 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) ADJ73_00670 ENOG4105E33 succinate dehydrogenase ADJ73_00710 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ADJ73_00715 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ADJ73_00720 ENOG4105C6V Glycerol-3-phosphate dehydrogenase ADJ73_00725 ENOG4105DKT Transcriptional regulator ADJ73_00745 ENOG4108RIR Molybdenum cofactor biosynthesis protein ADJ73_00750 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ADJ73_00765 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase ADJ73_00790 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) ADJ73_00805 ENOG4105D5G Transposase ADJ73_00825 ENOG4107R5H iron (metal) dependent repressor, dtxr family ADJ73_00830 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) ADJ73_00845 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) ADJ73_00855 ENOG4105XMC MarR family Transcriptional regulator ADJ73_00860 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) ADJ73_00865 ENOG4105C7N Xanthine uracil vitamin C permease ADJ73_00885 ENOG4105VEQ Cold shock protein ADJ73_00900 ENOG4105CEY Amp-dependent synthetase and ligase ADJ73_00910 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase ADJ73_00915 ENOG4105CFI type iii restriction protein res subunit ADJ73_00920 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ADJ73_00925 ENOG4105BZU Histidine kinase ADJ73_00930 ENOG4105C0H protease ADJ73_00935 ENOG4105EEM helicase ADJ73_00955 ENOG4108594 Permease of the drug metabolite transporter ADJ73_00965 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ADJ73_00985 ENOG4105JXH GntR family transcriptional regulator ADJ73_01000 ENOG4108YIQ Alpha beta hydrolase ADJ73_01005 ENOG4105CSH Transporter ADJ73_01015 ENOG4105KXX peptidase s58 dmpa ADJ73_01025 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ADJ73_01030 ENOG4105C19 ABC transporter ADJ73_01035 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) ADJ73_01050 ENOG4105DYW oxidoreductase ADJ73_01055 ENOG4105C1G acyl-Coa dehydrogenase ADJ73_01065 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap ADJ73_01085 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) ADJ73_01095 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone ADJ73_01110 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) ADJ73_01120 ENOG4105BZ1 (ABC) transporter ADJ73_01130 ENOG4107R3N Filamentation induced by cAMP protein fic ADJ73_01150 ENOG4108762 serine threonine protein kinase ADJ73_01160 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase ADJ73_01170 ENOG4105ETE Transcriptional regulator (LacI family ADJ73_01175 ENOG4105EG2 ABC transporter, permease ADJ73_01180 ENOG4105D56 permease protein ADJ73_01185 ENOG4107FKK extracellular solute-binding protein family 1 ADJ73_01190 ENOG4108IJ9 (ABC) transporter ADJ73_01200 ENOG4105C2N RNA methyltransferase TrmH family group 3 ADJ73_01205 ENOG4105C8N cysteinyl-tRNA synthetase ADJ73_01215 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) ADJ73_01220 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) ADJ73_01235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ADJ73_01240 ENOG4105BZU Histidine kinase ADJ73_01250 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ADJ73_01275 ENOG4106UW1 Major Facilitator superfamily ADJ73_01290 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) ADJ73_01310 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) ADJ73_01320 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands ADJ73_01335 ENOG4107NHD transcriptional regulator ADJ73_01340 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) ADJ73_01350 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) ADJ73_01365 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ADJ73_01395 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) ADJ73_01435 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ADJ73_01440 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) ADJ73_01465 ENOG4105DTD Dehydrogenase ADJ73_01470 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) ADJ73_01490 ENOG4105CVP deoxyribo-dipyrimidine photolyase ADJ73_01495 ENOG4105KAV tspo and mbr like protein ADJ73_01510 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) ADJ73_01550 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ADJ73_01640 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase ADJ73_01645 ENOG4105CPC Aldo Keto reductase ADJ73_01650 ENOG4105EJQ L-serine dehydratase ADJ73_01655 ENOG4105DCG PHP domain protein ADJ73_01700 ENOG4105CXB phosphoribosylaminoimidazole synthetase ADJ73_01715 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone ADJ73_01735 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) ADJ73_01740 ENOG4108ETH Formylglycinamide ribotide synthetase ADJ73_01750 ENOG4105C8V SAICAR synthetase ADJ73_01755 ENOG4105C12 Phosphoribosylglycinamide synthetase ADJ73_01765 ENOG4105EHE chorismate mutase- prephenate dehydrogenase ADJ73_01770 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis ADJ73_01785 ENOG4107RCW fructose-bisphosphate aldolase ADJ73_01795 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN ADJ73_01805 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) ADJ73_01815 ENOG4105CGK Exodeoxyribonuclease III ADJ73_01825 ENOG4107UWP Major facilitator superfamily MFS_1 ADJ73_01835 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase ADJ73_01840 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) ADJ73_01845 ENOG4105DWF phosphomethylpyrimidine kinase ADJ73_01850 ENOG4105DWF phosphomethylpyrimidine kinase ADJ73_01855 ENOG4105C85 amino acid ADJ73_01865 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) ADJ73_01870 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ADJ73_01895 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) ADJ73_01905 ENOG4108UVJ appr-1-p processing domain protein ADJ73_01920 ENOG4105KNI merR family transcriptional Regulator ADJ73_01925 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ADJ73_01930 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ ADJ73_01935 ENOG4105CFG Acts as a chaperone (By similarity) ADJ73_02005 ENOG41079KZ Major Facilitator Superfamily ADJ73_02030 ENOG4105CPC Aldo Keto reductase ADJ73_02035 ENOG4105BZP glycoside hydrolase 15-related ADJ73_02045 ENOG4105VPX protein, conserved in bacteria ADJ73_02085 ENOG4105CHF Glutathione S-transferase ADJ73_02090 ENOG4105DSQ Nitric oxide reductase ADJ73_02100 ENOG4105CQ7 ATP-dependent helicase ADJ73_02150 ENOG4107XWI flavin reductase domain protein, FMN-binding ADJ73_02170 ENOG4105CHR reductase ADJ73_02175 ENOG4105CHU acetyl-coa acetyltransferase ADJ73_02190 ENOG4105K6V RNA polymerase ADJ73_02195 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ADJ73_02200 ENOG4108R3E Dna-3-methyladenine glycosylase i ADJ73_02205 ENOG4108IQE Amp-dependent synthetase and ligase ADJ73_02220 ENOG4105D82 Glutamate dehydrogenase ADJ73_02225 ENOG4107VXM glycerophosphoryl diester phosphodiesterase ADJ73_02250 ENOG4105CE4 GlcNAc 6-P deacetylase ADJ73_02255 ENOG4105CI1 PTS System ADJ73_02260 ENOG4105FDP GntR family transcriptional regulator ADJ73_02265 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ADJ73_02280 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 ADJ73_02290 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ADJ73_02325 ENOG4105C5I Dehydrogenase ADJ73_02355 ENOG4105BZW Glycerate kinase ADJ73_02365 ENOG4107QSA Oxaloacetate decarboxylase ADJ73_02370 ENOG4107QX3 carboxylase ADJ73_02380 ENOG4107QSA Oxaloacetate decarboxylase ADJ73_02385 ENOG4108WYP Transcriptional regulator ADJ73_02390 ENOG4105K6H D-cysteine desulfhydrase ADJ73_02400 ENOG4105CQB FAD linked oxidase domain protein ADJ73_02405 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) ADJ73_02410 ENOG4105CI0 Citrate lyase ADJ73_02415 ENOG4105CI0 Citrate lyase ADJ73_02420 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ADJ73_02450 ENOG4105GCF PGAM ADJ73_02485 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ADJ73_02510 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ADJ73_02525 ENOG4105D74 hydrolase ADJ73_02535 ENOG4105P8F nudix hydrolase ADJ73_02600 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase ADJ73_02605 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ADJ73_02620 ENOG4105C8Y Acetylornithine aminotransferase ADJ73_02635 ENOG4105CTS PTS system mannitol-specific ADJ73_02640 ENOG4105DEN Luciferase family ADJ73_02645 ENOG4105BZN citrate synthase ADJ73_02650 ENOG4105BZN citrate synthase ADJ73_02655 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ADJ73_02660 ENOG4105CFH Aspartokinase ADJ73_02670 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ADJ73_02685 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) ADJ73_02695 ENOG4105CEY Amp-dependent synthetase and ligase ADJ73_02705 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) ADJ73_02720 ENOG4105D7A ATP-binding protein ADJ73_02730 ENOG4108IUK alpha amylase, catalytic ADJ73_02735 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin ADJ73_02740 ENOG4105E39 Enoyl-CoA hydratase ADJ73_02755 ENOG4108Z6B deaminase ADJ73_02760 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) ADJ73_02775 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ADJ73_02780 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ADJ73_02790 ENOG4108JJB ABC transporter ADJ73_02800 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) ADJ73_02805 ENOG4105CUB amino acid ADJ73_02830 ENOG410667J hydrolase ADJ73_02835 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) ADJ73_02855 ENOG4105EYF MMPL domain protein ADJ73_02860 ENOG4105C5W Aldolase ADJ73_02875 ENOG4105DBE peroxidase ADJ73_02880 ENOG410650H (LipO)protein ADJ73_02905 ENOG4105FDF Could be involved in DNA repair (By similarity) ADJ73_02950 ENOG4105C30 Nad-dependent epimerase dehydratase ADJ73_02955 ENOG4105C0K Gdp-mannose 4,6-dehydratase ADJ73_02960 ENOG4106CD9 glycosyl transferase group 1 ADJ73_03000 ENOG4105D3Q Sugar transferase ADJ73_03025 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family ADJ73_03030 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) ADJ73_03040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ADJ73_03045 ENOG4105BZU Histidine kinase ADJ73_03050 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein ADJ73_03055 ENOG4105EDW glycosyl transferase, family 39 ADJ73_03075 ENOG4105VEQ Cold shock protein ADJ73_03095 ENOG4105D7W serine acetyltransferase ADJ73_03120 ENOG4105DHP deoxycytidine triphosphate deaminase ADJ73_03135 ENOG4105CSU acyl-Coa dehydrogenase ADJ73_03170 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) ADJ73_03180 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) ADJ73_03190 ENOG4105E90 ABC transporter ADJ73_03195 ENOG4105E90 ABC transporter ADJ73_03200 ENOG4108IJ8 ABC transporter ADJ73_03225 ENOG4105CSR polyphosphate kinase 2 ADJ73_03270 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 ADJ73_03275 ENOG4105CPP Dehydrogenase, E1 component ADJ73_03290 ENOG4105CIH Imidazole acetol-phosphate transaminase ADJ73_03295 ENOG41082T9 Membrane ADJ73_03350 ENOG4105NAE bifunctional deaminase-reductase domain protein ADJ73_03370 ENOG4105VT3 DNA binding domain protein, excisionase family ADJ73_03380 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) ADJ73_03385 ENOG41068WN ADJ73_03410 ENOG4105E5G Alpha beta hydrolase fold ADJ73_03420 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ADJ73_03475 ENOG4105CMR udp-glucose 4-epimerase ADJ73_03480 ENOG4105C4M (Ubiquinol oxidase) subunit I ADJ73_03485 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ADJ73_03490 ENOG4108JJ9 ABC, transporter ADJ73_03495 ENOG4108JJ8 (ABC) transporter ADJ73_03500 ENOG4105KJF protein tyrosine phosphatase ADJ73_03515 ENOG4105C5H ABC transporter ADJ73_03540 ENOG4105CIG ABC transporter ADJ73_03565 ENOG4107QTF adenylosuccinate lyase ADJ73_03590 ENOG4105VPX protein, conserved in bacteria ADJ73_03610 ENOG4108RWN rrna methyltransferase ADJ73_03630 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) ADJ73_03640 ENOG410841Q phosphoesterase PA-phosphatase related protein ADJ73_03655 ENOG4105EC3 peptidase S51, dipeptidase E ADJ73_03665 ENOG4105RHA ABC transporter, permease ADJ73_03670 ENOG4108IUX (ABC) transporter ADJ73_03675 ENOG4105WH1 Two component transcriptional regulator luxr family ADJ73_03680 ENOG4108ZGX Histidine kinase ADJ73_03730 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) ADJ73_03735 ENOG41067RQ csbd family ADJ73_03750 ENOG4105CIG ABC transporter ADJ73_03755 ENOG4105DIM ABC transporter ADJ73_03775 ENOG4105EYF MMPL domain protein ADJ73_03785 ENOG4108YYH Nadph-dependent fmn reductase ADJ73_03790 ENOG41072TH Protein of unknown function (DUF1479) ADJ73_03795 ENOG4105E2R ROK family ADJ73_03815 ENOG4107Y9U Membrane ADJ73_03835 ENOG4105BZU Histidine kinase ADJ73_03840 ENOG4105WH1 Two component transcriptional regulator luxr family ADJ73_03850 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ADJ73_03855 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ADJ73_03860 ENOG4105WBV Transcriptional regulator ADJ73_03865 ENOG4107SCA Formamidase (EC 3.5.1.49) ADJ73_03870 ENOG4105C85 amino acid ADJ73_03890 ENOG4105C57 major facilitator superfamily ADJ73_03915 ENOG4105CHP RNA polymerase ADJ73_03960 ENOG4105CGD Nad-dependent epimerase dehydratase ADJ73_04015 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein ADJ73_04025 ENOG4105CVR type I restriction-modification system ADJ73_04050 ENOG4107SCJ type I restriction enzyme EcoKI subunit R ADJ73_04080 ENOG4105C72 UPF0176 protein ADJ73_04145 ENOG4105J4Q Transcriptional regulator ADJ73_04155 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase ADJ73_04175 ENOG4105GVJ transcriptional regulator ADJ73_04190 ENOG4105ERH Fumarylacetoacetate hydrolase ADJ73_04205 ENOG4105DBV ornithine carbamoyltransferase ADJ73_04210 ENOG4105CEU Arginine dihydrolase ADJ73_04230 ENOG4105CTQ phosphohexokinase ADJ73_04235 ENOG4105C75 arginyL-tRNA synthetase ADJ73_04265 ENOG4105DWF phosphomethylpyrimidine kinase ADJ73_04290 ENOG4107R16 Multicopper oxidase ADJ73_04300 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ADJ73_04305 ENOG4105EB3 Histidine kinase ADJ73_04335 ENOG4107R7A Allophanate hydrolase subunit 2 ADJ73_04340 ENOG4105E7W lamb ycsf family protein ADJ73_04350 ENOG4106CC8 Bacterial inner membrane protein ADJ73_04365 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ADJ73_04380 ENOG4105CSH Transporter ADJ73_04390 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) ADJ73_04410 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) ADJ73_04445 ENOG4105CSH Transporter ADJ73_04455 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ADJ73_04460 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ADJ73_04465 ENOG4105ENR peptidase, M24 ADJ73_04475 ENOG4108JPW Aminotransferase ADJ73_04495 ENOG4105D7Z glutathione synthase ADJ73_04535 ENOG4105BZU Histidine kinase ADJ73_04555 ENOG4108M6P methyltransferase ADJ73_04570 ENOG41090MF Protein of unknown function (DUF3068) ADJ73_04575 ENOG4107VFM Dehydrogenase ADJ73_04585 ENOG4105CY2 Citrate transporter ADJ73_04595 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein ADJ73_04600 ENOG4108ZHJ Organic hydroperoxide resistance protein ADJ73_04605 ENOG4105K56 Transcriptional regulator ADJ73_04730 ENOG4107QRT dEAD DEAH box helicase ADJ73_04740 ENOG4105CB5 ATP-dependent DNA helicase recG ADJ73_04770 ENOG4105C2J ABC transporter ADJ73_04775 ENOG4105CNN ABC, transporter ADJ73_04780 ENOG41062B0 ABC transporter, permease ADJ73_04870 ENOG4105PGM cation diffusion facilitator family transporter ADJ73_04910 ENOG4105G6Z alkaline phosphatase ADJ73_04925 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) ADJ73_04935 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) ADJ73_04995 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) ADJ73_05035 ENOG4105C0A alcohol dehydrogenase ADJ73_05040 ENOG4105CS9 pantothenic acid kinase ADJ73_05045 ENOG4105KVH Transcriptional regulator ADJ73_05050 ENOG4108RYK Nad-dependent epimerase dehydratase ADJ73_05080 ENOG4105HZM Fha domain containing protein ADJ73_05095 ENOG4105CJN penicillin-binding protein ADJ73_05100 ENOG4105D9P serine threonine protein kinase ADJ73_05125 ENOG4105ZJT Cell division protein CrgA ADJ73_05135 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) ADJ73_05170 ENOG4108ZED Transmembrane domain of unknown function (DUF3566) ADJ73_05175 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ADJ73_05180 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ADJ73_05185 ENOG4105ME7 Membrane ADJ73_05215 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) ADJ73_05220 ENOG4108J5G 6-phosphogluconate dehydrogenase ADJ73_05225 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ADJ73_05230 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) ADJ73_05235 ENOG41084CH 50S ribosomal protein l34 ADJ73_05240 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) ADJ73_05250 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins ADJ73_05265 ENOG4107QJE Chromosome Partitioning Protein ADJ73_05275 ENOG4105CPF Cell wall formation (By similarity) ADJ73_05280 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ADJ73_05290 ENOG4105K63 Thioredoxin ADJ73_05295 ENOG4105C3M thioredoxin reductase ADJ73_05330 ENOG4105DJ0 Poly(A) Polymerase ADJ73_05335 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase ADJ73_05380 ENOG4108IJ1 Dehydrogenase ADJ73_05390 ENOG4105CZA synthase ADJ73_05405 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) ADJ73_05415 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) ADJ73_05420 ENOG4105K9Q Binds to the 23S rRNA (By similarity) ADJ73_05425 ENOG4108TZY GntR Family Transcriptional Regulator ADJ73_05430 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) ADJ73_05455 ENOG41060NJ transcriptional regulator ADJ73_05460 ENOG4105F8D glycoside hydrolase family 4 ADJ73_05470 ENOG4105EDK PfkB domain protein ADJ73_05480 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component ADJ73_05485 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component ADJ73_05505 ENOG410829K Lysine exporter protein (Lyse ygga) ADJ73_05520 ENOG4105FDP GntR family transcriptional regulator ADJ73_05525 ENOG4105D7K pfkb domain protein ADJ73_05535 ENOG4105DH8 myo-inositol catabolism ADJ73_05540 ENOG4105C26 Dehydrogenase ADJ73_05550 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) ADJ73_05555 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) ADJ73_05560 ENOG4105F0H myo-inositol catabolism protein ADJ73_05565 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) ADJ73_05580 ENOG41062B0 ABC transporter, permease ADJ73_05585 ENOG4105C2J ABC transporter ADJ73_05595 ENOG4107QNK )-transporter ADJ73_05600 ENOG4105CHR reductase ADJ73_05620 ENOG4105EE0 oxidoreductase ADJ73_05635 ENOG4107QI1 Mate efflux family protein ADJ73_05685 ENOG4105MP0 transposase ADJ73_05765 ENOG4105BZU Histidine kinase ADJ73_05770 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ADJ73_05780 ENOG4107R16 Multicopper oxidase ADJ73_05820 ENOG4105MP0 transposase ADJ73_05845 ENOG4105DWV Homoserine O-trans-acetylase ADJ73_05855 ENOG410905P Pyridoxamine 5-phosphate ADJ73_05865 ENOG4105CD3 dihydroorotase ADJ73_05875 ENOG4105ERH Fumarylacetoacetate hydrolase ADJ73_05880 ENOG4108QBF Transcriptional regulator ADJ73_05895 ENOG4105EGE secreted protein ADJ73_05975 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) ADJ73_05980 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ADJ73_05985 ENOG4105E9F Enoyl-CoA hydratase ADJ73_05995 ENOG4105D2S major facilitator superfamily ADJ73_06005 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha ADJ73_06010 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase ADJ73_06015 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase ADJ73_06025 ENOG4107QNJ CoA-transferase subunit B ADJ73_06045 ENOG4105E8R UPF0173 metal-dependent hydrolase ADJ73_06060 ENOG4105E9Z Nad-dependent epimerase dehydratase ADJ73_06065 ENOG4105DXB Major Facilitator superfamily ADJ73_06115 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ADJ73_06195 ENOG4105WH1 Two component transcriptional regulator luxr family ADJ73_06200 ENOG4108W6G cytochrome C ADJ73_06215 ENOG4107QIV Cytochrome c biogenesis protein ADJ73_06220 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) ADJ73_06225 ENOG4105CRE cytochrome C ADJ73_06245 ENOG4105C37 (CBS) domain ADJ73_06295 ENOG4105C7K acetolactate synthase ADJ73_06335 ENOG4108YYC ycei family ADJ73_06385 ENOG4105C28 cystathionine ADJ73_06400 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) ADJ73_06415 ENOG4105F0I Aminotransferase ADJ73_06440 ENOG4105DSF transport protein ADJ73_06450 ENOG4105C1G acyl-Coa dehydrogenase ADJ73_06455 ENOG4105CHR reductase ADJ73_06470 ENOG4105CHR reductase ADJ73_06500 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) ADJ73_06505 ENOG4105CPF Cell wall formation (By similarity) ADJ73_06535 ENOG4105CEY Amp-dependent synthetase and ligase ADJ73_06540 ENOG4105EG6 Saccharopine dehydrogenase ADJ73_06575 ENOG4108URH decarboxylase ADJ73_06585 ENOG4107RDP Dehydrogenase ADJ73_06605 ENOG4105DSB aldose 1-epimerase ADJ73_06610 ENOG4105CSW GntR family transcriptional regulator ADJ73_06615 ENOG4108VW9 Membrane ADJ73_06620 ENOG4105DRP amino acid AbC transporter ADJ73_06625 ENOG4108Q1T ABC transporter ADJ73_06630 ENOG4107UBR Extracellular solute-binding protein family 3 ADJ73_06635 ENOG4105CDA abc transporter atp-binding protein ADJ73_06650 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) ADJ73_06665 ENOG4105C26 Dehydrogenase ADJ73_06685 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) ADJ73_06685 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) ADJ73_06705 ENOG4107DKM chad domain containing protein ADJ73_06720 ENOG4105D5U fad dependent oxidoreductase ADJ73_06765 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ADJ73_06775 ENOG4105DFM M18 family aminopeptidase ADJ73_06800 ENOG4105X1P Steroid delta-isomerase ADJ73_06805 ENOG4105C84 Histidine ammonia-lyase ADJ73_06815 ENOG4108MJN Glycosyl Transferase ADJ73_06820 ENOG4105VEQ Cold shock protein ADJ73_06825 ENOG4105CGP Urocanate hydratase ADJ73_06830 ENOG4105ETS cytosine purines uracil thiamine allantoin ADJ73_06845 ENOG4105E2A Dehydrogenase ADJ73_06850 ENOG4108Z0Z intracellular protease Pfpi family ADJ73_06865 ENOG4108S01 response regulator ADJ73_06895 ENOG4105CI2 imidazolone-5-propionate hydrolase ADJ73_06905 ENOG4105BZU Histidine kinase ADJ73_06910 ENOG4105WH1 Two component transcriptional regulator luxr family ADJ73_06915 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ADJ73_06920 ENOG4107R34 abc transporter permease protein ADJ73_06935 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein ADJ73_06940 ENOG4108JJB ABC transporter ADJ73_07000 ENOG4105EUB pirin domain protein ADJ73_07010 ENOG4108426 dNA-binding protein ADJ73_07015 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) ADJ73_07020 ENOG4105W0E 50S ribosomal protein L33 ADJ73_07030 ENOG4105KDC 50s ribosomal protein l28 ADJ73_07040 ENOG4105KPY Small multidrug resistance protein ADJ73_07060 ENOG4105DSE periplasmic solute binding protein ADJ73_07070 ENOG4105D94 Major Facilitator Superfamily ADJ73_07075 ENOG4107QN1 sodium solute ADJ73_07100 ENOG4108HRK Histidine kinase ADJ73_07175 ENOG4108I5C dEAD DEAH box helicase ADJ73_07185 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ADJ73_07190 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b ADJ73_07195 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ADJ73_07215 ENOG4108WUZ (ABC) transporter ADJ73_07220 ENOG4107TXC Transcriptional regulator ADJ73_07235 ENOG4107U9T Pfam:Ribonuclease_BN ADJ73_07240 ENOG4105BZU Histidine kinase ADJ73_07245 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) ADJ73_07250 ENOG4105FA2 dna polymerase iii ADJ73_07290 ENOG4105F0N pyrophosphate phospho-hydrolase ADJ73_07295 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family ADJ73_07305 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) ADJ73_07315 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ADJ73_07320 ENOG4105EUJ GTP cyclohydrolase i ADJ73_07325 ENOG4105CRK lysyL-tRNA synthetase ADJ73_07330 ENOG4105EEI dihydropteroate synthase ADJ73_07335 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ADJ73_07350 ENOG4105CRK lysyL-tRNA synthetase ADJ73_07355 ENOG4105RFA Lsr2-like protein ADJ73_07370 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ADJ73_07390 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) ADJ73_07405 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ADJ73_07410 ENOG4108JWX ADJ73_07415 ENOG4107R33 ppx gppa phosphatase ADJ73_07420 ENOG4105EY0 Xylose isomerase domain protein TIM barrel ADJ73_07460 ENOG4105DGU Histone deacetylase ADJ73_07495 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) ADJ73_07505 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) ADJ73_07510 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ADJ73_07515 ENOG4105D52 delta-aminolevulinic acid dehydratase ADJ73_07525 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase ADJ73_07530 ENOG4108RH7 phosphoglycerate mutase ADJ73_07535 ENOG4107QX9 Thiol disulfide interChange protein ADJ73_07540 ENOG4107QIV Cytochrome c biogenesis protein ADJ73_07550 ENOG4105CRE cytochrome C ADJ73_07560 ENOG4108NIW Leucine export protein LeuE ADJ73_07605 ENOG4105YES addiction module antidote protein ADJ73_07615 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) ADJ73_07640 ENOG4108UQY Iron-storage protein ADJ73_07660 ENOG4107TCW O-succinylbenzoate synthase ADJ73_07665 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) ADJ73_07685 ENOG4105C9K Endothelin-converting enzyme 1 ADJ73_07705 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ADJ73_07720 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ADJ73_07725 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain ADJ73_07730 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ADJ73_07745 ENOG4108IEH NADH dehydrogenase subunit g ADJ73_07750 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) ADJ73_07760 ENOG4105DF2 NADH dehydrogenase subunit j ADJ73_07765 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ADJ73_07770 ENOG4105D65 subunit l ADJ73_07780 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ADJ73_07810 ENOG4105D0M Protease HtpX homolog ADJ73_07825 ENOG4108VPT UPF0234 protein ADJ73_07845 ENOG4105C0X amino acid ADJ73_07860 ENOG4105C6K Malic enzyme ADJ73_07865 ENOG41079KZ Major Facilitator Superfamily ADJ73_07875 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein ADJ73_07880 ENOG4108KK1 membrane protein AbrB duplication ADJ73_07885 ENOG4107ZYJ bioY protein ADJ73_07890 ENOG4108JJB ABC transporter ADJ73_07895 ENOG4107U45 Cobalt transport protein ADJ73_07900 ENOG4107RJF diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90) ADJ73_07920 ENOG4105CHM Aminotransferase ADJ73_07930 ENOG4105DQU oxidoreductase, subunit beta ADJ73_07950 ENOG4105WDJ 50S ribosomal protein L33 ADJ73_07955 ENOG410900P UPF0336 protein ADJ73_07965 ENOG4107R4N Cell wall formation (By similarity) ADJ73_07995 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) ADJ73_08000 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) ADJ73_08010 ENOG4108VZM 50s ribosomal protein L10 ADJ73_08015 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) ADJ73_08020 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ADJ73_08025 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ADJ73_08030 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) ADJ73_08035 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) ADJ73_08040 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ADJ73_08050 ENOG4105E39 Enoyl-CoA hydratase ADJ73_08065 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) ADJ73_08070 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) ADJ73_08075 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) ADJ73_08080 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) ADJ73_08085 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity ADJ73_08090 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) ADJ73_08095 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) ADJ73_08100 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) ADJ73_08105 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) ADJ73_08110 ENOG41082SA 50s ribosomal protein l29 ADJ73_08115 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal ADJ73_08120 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) ADJ73_08125 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) ADJ73_08130 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits ADJ73_08135 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) ADJ73_08140 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) ADJ73_08145 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) ADJ73_08150 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) ADJ73_08155 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) ADJ73_08160 ENOG410849U 50S ribosomal protein L30 ADJ73_08165 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) ADJ73_08170 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) ADJ73_08175 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) ADJ73_08185 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) ADJ73_08190 ENOG41067V7 50S ribosomal protein L36 ADJ73_08195 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits ADJ73_08200 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) ADJ73_08210 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ADJ73_08215 ENOG4108ZT0 50S ribosomal protein l17 ADJ73_08220 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) ADJ73_08240 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) ADJ73_08245 ENOG4108UJD 30S ribosomal protein S9 ADJ73_08250 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) ADJ73_08270 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 ADJ73_08305 ENOG4107GFK fumarate ADJ73_08315 ENOG4105EPJ extracellular solute-binding protein family 1 ADJ73_08320 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component ADJ73_08325 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component ADJ73_08330 ENOG4105EPJ extracellular solute-binding protein family 1 ADJ73_08335 ENOG4105D7K pfkb domain protein ADJ73_08345 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ADJ73_08350 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ADJ73_08355 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) ADJ73_08365 ENOG4105Z5Q ADJ73_08375 ENOG4105KIJ D-ornithine aminomutase S component ADJ73_08380 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit ADJ73_08390 ENOG4106M28 alanine racemase domain protein ADJ73_08395 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ADJ73_08440 ENOG4105CGY Dna recombination protein ADJ73_08455 ENOG4105C3G gtp-binding protein ADJ73_08480 ENOG4105CCI Myosin-Cross-Reactive Antigen ADJ73_08490 ENOG4105DYW oxidoreductase ADJ73_08510 ENOG4105BZU Histidine kinase ADJ73_08525 ENOG4108NRW Phospholipase, patatin family ADJ73_08535 ENOG4108IQI permease ADJ73_08545 ENOG4105C01 Dihydroxy-acid dehydratase ADJ73_08565 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for ADJ73_08570 ENOG4105EXC Acyl-transferase ADJ73_08580 ENOG4105M6F mutator MutT protein ADJ73_08585 ENOG4105CI3 gtp-binding protein typa ADJ73_08590 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ADJ73_08605 ENOG4105C3U ABC transporter ADJ73_08610 ENOG4108JQ7 (ABC) transporter ADJ73_08615 ENOG4105CSR polyphosphate kinase 2 ADJ73_08620 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) ADJ73_08630 ENOG4107RBI VanW family ADJ73_08635 ENOG4108Z4U Ferredoxin ADJ73_08660 ENOG4107R4C succinyl-diaminopimelate desuccinylase ADJ73_08665 ENOG4108URH decarboxylase ADJ73_08680 ENOG4108UKI Enoyl-CoA hydratase ADJ73_08690 ENOG4105DU6 RNA polymerase ADJ73_08695 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) ADJ73_08710 ENOG4105CJW magnesium transporter ADJ73_08730 ENOG4105C1G acyl-Coa dehydrogenase ADJ73_08740 ENOG4107T6F Xaa-Pro aminopeptidase ADJ73_08750 ENOG4105DJG MaoC domain protein dehydratase ADJ73_08755 ENOG4105DB7 PHP domain protein ADJ73_08765 ENOG4105C94 Transporter ADJ73_08770 ENOG4105C1J atp-dependent rna helicase ADJ73_08810 ENOG4105C4R Atp-dependent dna helicase ADJ73_08835 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) ADJ73_08855 ENOG4105E39 Enoyl-CoA hydratase ADJ73_08880 ENOG41063PX domain protein ADJ73_08890 ENOG4105DJZ UPF0182 protein ADJ73_08920 ENOG4105C1V Peptidase, M16 ADJ73_08930 ENOG4107TK4 histidinol-phosphate phosphatase ADJ73_08935 ENOG410841Q phosphoesterase PA-phosphatase related protein ADJ73_08940 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) ADJ73_08945 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase ADJ73_08950 ENOG4108RAV Conserved protein ADJ73_08955 ENOG4105EMN RNA polymerase sigma factor ADJ73_08960 ENOG4105WMN AntiSigma factor ADJ73_08970 ENOG4108VEQ Superoxide dismutase ADJ73_08995 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 ADJ73_09000 ENOG4105C37 (CBS) domain ADJ73_09010 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) ADJ73_09015 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase ADJ73_09020 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) ADJ73_09045 ENOG4107QKV phosphomannomutase ADJ73_09050 ENOG4105W49 UPF0434 protein ADJ73_09060 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) ADJ73_09085 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea ADJ73_09090 ENOG4105WH1 Two component transcriptional regulator luxr family ADJ73_09095 ENOG4105T0Z Conserved Protein ADJ73_09100 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving ADJ73_09130 ENOG4107SKI cobyrinic Acid a,c-diamide synthase ADJ73_09135 ENOG4105D3Q Sugar transferase ADJ73_09160 ENOG4105C7I Dehydrogenase ADJ73_09235 ENOG4107EJG GntR family transcriptional regulator ADJ73_09240 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family ADJ73_09245 ENOG4105C6Z Gluconate ADJ73_09250 ENOG4105C2J ABC transporter ADJ73_09255 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) ADJ73_09280 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) ADJ73_09290 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) ADJ73_09295 ENOG4105DXI Major Facilitator superfamily ADJ73_09315 ENOG4105D44 asparaginase ADJ73_09325 ENOG41080RH Thioredoxin ADJ73_09330 ENOG4105C1J atp-dependent rna helicase ADJ73_09335 ENOG4108UJU UPF0301 protein ADJ73_09360 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase ADJ73_09385 ENOG4108RWI nicotinamidase ADJ73_09395 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin ADJ73_09400 ENOG4105C26 Dehydrogenase ADJ73_09410 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) ADJ73_09425 ENOG4105E5Q amino acid AbC transporter ADJ73_09440 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) ADJ73_09445 ENOG4108RQ5 Beta-lactamase domain-containing protein ADJ73_09465 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) ADJ73_09470 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ADJ73_09475 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) ADJ73_09510 ENOG4105VRS hydrolase family 18 ADJ73_09520 ENOG4107QQG Dehydrogenase ADJ73_09550 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) ADJ73_09585 ENOG4105CGH 5'-nucleotidase ADJ73_09630 ENOG4105C29 acyl-CoA thioesterase ADJ73_09640 ENOG4105C9U ATP-dependent DNA helicase RecQ ADJ73_09665 ENOG4105CG3 alpha amylase, catalytic region ADJ73_09675 ENOG4105D8X mechanosensitive ion channel ADJ73_09685 ENOG4105EAB amino acid AbC transporter ADJ73_09690 ENOG4105E5Q amino acid AbC transporter ADJ73_09695 ENOG4108JEH abc transporter atp-binding protein ADJ73_09705 ENOG4105MC2 DSBA oxidoreductase ADJ73_09710 ENOG4108YZG isomerase ADJ73_09730 ENOG4105CHU acetyl-coa acetyltransferase ADJ73_09740 ENOG4107QNJ CoA-transferase subunit B ADJ73_09755 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ADJ73_09760 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ADJ73_09765 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) ADJ73_09780 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ADJ73_09805 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) ADJ73_09810 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) ADJ73_09820 ENOG4105DHU Bile acid ADJ73_09825 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A ADJ73_09835 ENOG4105CQB FAD linked oxidase domain protein ADJ73_09840 ENOG4105CYC Transferase ADJ73_09850 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase ADJ73_09855 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) ADJ73_09860 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase ADJ73_09870 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) ADJ73_09885 ENOG4105D22 carbon starvation protein ADJ73_09900 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) ADJ73_09905 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) ADJ73_09920 ENOG4105CQB FAD linked oxidase domain protein ADJ73_09925 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) ADJ73_09930 ENOG41080R8 Conserved Protein ADJ73_09940 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ADJ73_09945 ENOG4105DAA L-lactate ADJ73_09950 ENOG4105JXH GntR family transcriptional regulator ADJ73_09960 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit ADJ73_09965 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit ADJ73_09970 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit ADJ73_09975 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit ADJ73_09980 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ADJ73_09995 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) ADJ73_10000 ENOG4108V4M Cobalt abc transporter ADJ73_10005 ENOG4108JJB ABC transporter ADJ73_10020 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) ADJ73_10045 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) ADJ73_10060 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) ADJ73_10075 ENOG4108IJ6 ABC transporter ADJ73_10080 ENOG4105I5W Transporter ADJ73_10160 ENOG4105CQB FAD linked oxidase domain protein ADJ73_10165 ENOG410635A Membrane ADJ73_10175 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ADJ73_10185 ENOG4105C03 ribonuclease ADJ73_10190 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) ADJ73_10195 ENOG4105K46 50S ribosomal protein l27 ADJ73_10200 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control ADJ73_10205 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) ADJ73_10210 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) ADJ73_10215 ENOG4108KQJ Type 11 methyltransferase ADJ73_10230 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) ADJ73_10250 ENOG4105C8T Leucyl-tRNA synthetase ADJ73_10255 ENOG4105EPR degv family ADJ73_10265 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 ADJ73_10290 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) ADJ73_10310 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) ADJ73_10315 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ADJ73_10330 ENOG4108RTU Aldolase ADJ73_10340 ENOG4105DJB Major Facilitator Superfamily ADJ73_10350 ENOG4105ETE Transcriptional regulator (LacI family ADJ73_10355 ENOG4105C2J ABC transporter ADJ73_10360 ENOG4105CNN ABC, transporter ADJ73_10365 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ADJ73_10375 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) ADJ73_10385 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate ADJ73_10390 ENOG4105C5Y PTS System ADJ73_10395 ENOG4105C1G acyl-Coa dehydrogenase ADJ73_10415 ENOG4105DHS permease protein ADJ73_10420 ENOG4105CM4 permease protein ADJ73_10425 ENOG4108IPW abc transporter atp-binding protein ADJ73_10440 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein ADJ73_10455 ENOG4105CVG Homoserine O-transsuccinylase ADJ73_10475 ENOG4108JQ1 Dehydrogenase ADJ73_10490 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ADJ73_10495 ENOG4105C3U ABC transporter ADJ73_10505 ENOG4105C5F glutamine synthetase ADJ73_10520 ENOG4108IQE Amp-dependent synthetase and ligase ADJ73_10525 ENOG4108IQE Amp-dependent synthetase and ligase ADJ73_10550 ENOG4105CQ7 ATP-dependent helicase ADJ73_10565 ENOG4105CEI nitrite reductase ADJ73_10605 ENOG4105SHT UspA domain-containing protein ADJ73_10610 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ADJ73_10625 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ADJ73_10630 ENOG4108V6E Cell division protein mraZ ADJ73_10635 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) ADJ73_10655 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) ADJ73_10660 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) ADJ73_10670 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) ADJ73_10675 ENOG4105DFU Cell wall formation (By similarity) ADJ73_10685 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) ADJ73_10690 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase ADJ73_10700 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) ADJ73_10720 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) ADJ73_10730 ENOG4105C0B DNA polymerase III (alpha subunit) ADJ73_10745 ENOG4105DG4 malate L-lactate dehydrogenase ADJ73_10755 ENOG4105F9E Shikimate 5-dehydrogenase ADJ73_10795 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ADJ73_10800 ENOG4105C4B ABC transporter, permease ADJ73_10810 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) ADJ73_10815 ENOG4105CIH Imidazole acetol-phosphate transaminase ADJ73_10820 ENOG4105ECC imidazole-glycerol-phosphate dehydratase ADJ73_10830 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) ADJ73_10840 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase ADJ73_10865 ENOG4107QRI Phosphoketolase ADJ73_10870 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) ADJ73_10875 ENOG4108BNZ Ribosomal protein L35 ADJ73_10880 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) ADJ73_10885 ENOG4105C2N RNA methyltransferase TrmH family group 3 ADJ73_10890 ENOG4105BZU Histidine kinase ADJ73_10895 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) ADJ73_10900 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) ADJ73_10905 ENOG4105CHR reductase ADJ73_10910 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase ADJ73_10915 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) ADJ73_10920 ENOG4105CAS nag kinase ADJ73_10925 ENOG4105C8Y Acetylornithine aminotransferase ADJ73_10930 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) ADJ73_10935 ENOG4105CH7 arginosuccinase ADJ73_10950 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ADJ73_10980 ENOG4105DSU hydrolase ADJ73_10995 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ADJ73_11000 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) ADJ73_11030 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) ADJ73_11040 ENOG4105K5B UPF0225 protein ADJ73_11075 ENOG4105C9M aspartyl-trna synthetase ADJ73_11095 ENOG4105C3U ABC transporter ADJ73_11100 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ADJ73_11105 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ADJ73_11110 ENOG4105DEF Extracellular solute-binding protein, family 5 ADJ73_11140 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) ADJ73_11145 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) ADJ73_11150 ENOG4105HHA aminodeoxychorismate lyase ADJ73_11155 ENOG4105E2X shikimate dehydrogenase ADJ73_11160 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase ADJ73_11170 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) ADJ73_11175 ENOG4105D49 3-dehydroquinate synthase ADJ73_11185 ENOG4105WH1 Two component transcriptional regulator luxr family ADJ73_11190 ENOG4105BZU Histidine kinase ADJ73_11195 ENOG4105CJ1 ABC, transporter ADJ73_11210 ENOG4105CUC YeeE YedE family protein ADJ73_11215 ENOG4105CBC glutamate synthase ADJ73_11220 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) ADJ73_11225 ENOG410803B Involved in the transcription termination process (By similarity) ADJ73_11235 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) ADJ73_11240 ENOG4105CXT aspartate transcarbamylase ADJ73_11245 ENOG4105CD3 dihydroorotase ADJ73_11250 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain ADJ73_11255 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain ADJ73_11260 ENOG4105SKN orotidine 5''-phosphate decarboxylase ADJ73_11270 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) ADJ73_11275 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) ADJ73_11285 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP ADJ73_11300 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ADJ73_11305 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) ADJ73_11315 ENOG4105DJV ribulose-phosphate 3-epimerase ADJ73_11320 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase ADJ73_11325 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) ADJ73_11335 ENOG4105EIP mannose-6-phosphate isomerase ADJ73_11340 ENOG4105C2W permease ADJ73_11355 ENOG4105CAT Cytidine monophosphate kinase ADJ73_11365 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) ADJ73_11380 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase ADJ73_11410 ENOG4105DK0 Indole-3-glycerol phosphate synthase ADJ73_11415 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) ADJ73_11420 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) ADJ73_11435 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) ADJ73_11440 ENOG4105CBC glutamate synthase ADJ73_11450 ENOG4105CA9 Pyruvate kinase ADJ73_11475 ENOG4105KA0 thioesterase Superfamily protein ADJ73_11485 ENOG4105D65 subunit l ADJ73_11490 ENOG4105MKQ Monovalent cation H antiporter subunit C ADJ73_11495 ENOG4108JPZ Monovalent cation H antiporter subunit D ADJ73_11515 ENOG4105CKU formyltetrahydrofolate synthetase ADJ73_11525 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ADJ73_11530 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) ADJ73_11545 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) ADJ73_11550 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) ADJ73_11560 ENOG4107AQZ Membrane ADJ73_11570 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ADJ73_11575 ENOG4105CPQ Dehydrogenase ADJ73_11580 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) ADJ73_11590 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ADJ73_11600 ENOG4108IV0 ABC, transporter ADJ73_11605 ENOG4105C0Z ABC transporter ADJ73_11610 ENOG4105CF8 branched-chain amino acid ABC transporter, permease ADJ73_11615 ENOG4105C32 Amino acid ABC transporter (Permease) ADJ73_11625 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) ADJ73_11630 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) ADJ73_11640 ENOG4105CIE May be required for sporulation (By similarity) ADJ73_11645 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ADJ73_11650 ENOG4105BZA Phosphoglycerate kinase ADJ73_11655 ENOG4105CP7 Triose-phosphate isomerase ADJ73_11680 ENOG4105E0X reductase ADJ73_11695 ENOG4105GN4 DNA ligase ADJ73_11705 ENOG4105CSR polyphosphate kinase 2 ADJ73_11740 ENOG4105BZ4 penicillin-binding protein ADJ73_11775 ENOG4105C22 threonyL-tRNA synthetase ADJ73_11785 ENOG4108IQK o-acetylhomoserine ADJ73_11795 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein ADJ73_11860 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) ADJ73_11870 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ADJ73_11880 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) ADJ73_11885 ENOG4105CDY transcriptional regulatory protein ADJ73_11890 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) ADJ73_11895 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) ADJ73_11900 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) ADJ73_11910 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ADJ73_11915 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ADJ73_11920 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) ADJ73_11925 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ADJ73_11940 ENOG4105DA5 (ABC) transporter ADJ73_11960 ENOG4105C99 atpase involved in dna repair ADJ73_11965 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) ADJ73_11975 ENOG4105CUT histidyl-tRNA synthetase ADJ73_12000 ENOG4105DCF alanine dehydrogenase ADJ73_12025 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) ADJ73_12040 ENOG4105CAT Cytidine monophosphate kinase ADJ73_12060 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) ADJ73_12080 ENOG4107R3N Filamentation induced by cAMP protein fic ADJ73_12105 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ADJ73_12145 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone ADJ73_12160 ENOG4105CPC Aldo Keto reductase ADJ73_12170 ENOG4105C9Q fumarate hydratase class II ADJ73_12180 ENOG4105EE0 oxidoreductase ADJ73_12215 ENOG4108UW8 fha domain-containing protein ADJ73_12235 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor ADJ73_12270 ENOG4107RH8 nuclease SbcCD subunit D ADJ73_12280 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ADJ73_12320 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein ADJ73_12330 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) ADJ73_12335 ENOG4105D3G Pseudouridine synthase ADJ73_12360 ENOG4105D74 hydrolase ADJ73_12375 ENOG4108KPJ rna polymerase sigma factor ADJ73_12390 ENOG4105D9U N-acetyltransferase ADJ73_12400 ENOG410839S Toxic component of a toxin-antitoxin (TA) module (By similarity) ADJ73_12420 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ADJ73_12430 ENOG4105CJ1 ABC, transporter ADJ73_12445 ENOG4105C57 major facilitator superfamily ADJ73_12475 ENOG4105DEU major facilitator superfamily ADJ73_12490 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) ADJ73_12500 ENOG4108UYI beta-alanyl-CoA ammonia lyase ADJ73_12505 ENOG4107CHF 5,6-aminomutase beta subunit ADJ73_12510 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit ADJ73_12520 ENOG4105FRY Dehydrogenase ADJ73_12525 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein ADJ73_12530 ENOG4107RSM transcriptional regulator ADJ73_12535 ENOG4105DTQ mandelate racemase muconate lactonizing ADJ73_12540 ENOG4108QMY dioxygenase ADJ73_12550 ENOG4108Z66 YbaK ebsC protein ADJ73_12555 ENOG4105CHU acetyl-coa acetyltransferase ADJ73_12565 ENOG4105HFS 5'-3' exonuclease ADJ73_12580 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family ADJ73_12595 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) ADJ73_12620 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ADJ73_12660 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) ADJ73_12665 ENOG4105E5F proteasome ADJ73_12675 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ADJ73_12690 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) ADJ73_12715 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ADJ73_12720 ENOG4105C3R Methionine synthase ADJ73_12730 ENOG4105C8N cysteinyl-tRNA synthetase ADJ73_12750 ENOG4105D7N magnesium and cobalt transport protein CorA ADJ73_12765 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) ADJ73_12780 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ADJ73_12790 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ADJ73_12830 ENOG4105C1J atp-dependent rna helicase ADJ73_12850 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ADJ73_12865 ENOG4105BZ1 (ABC) transporter ADJ73_12870 ENOG4108V1U phospholipid-binding protein ADJ73_12885 ENOG4107QNK )-transporter ADJ73_12910 ENOG4105DKW ABC transporter ADJ73_12920 ENOG4107QPH glycogen) synthase ADJ73_12925 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) ADJ73_12930 ENOG4105EAC phosphoserine phosphatase ADJ73_12935 ENOG4105DDG Cyanophycinase ADJ73_12960 ENOG4105CHR reductase ADJ73_12975 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ADJ73_12985 ENOG4105BZ1 (ABC) transporter ADJ73_12990 ENOG4106YT9 Enoyl-CoA hydratase ADJ73_12995 ENOG4105C5H ABC transporter ADJ73_13005 ENOG4105CG3 alpha amylase, catalytic region ADJ73_13025 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) ADJ73_13030 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) ADJ73_13050 ENOG4105VG1 fes assembly suf system protein ADJ73_13055 ENOG4108UNV SUF system FeS assembly protein, NifU family ADJ73_13065 ENOG4105C3K feS assembly ATPase SufC ADJ73_13075 ENOG4105JRK feS assembly protein SufD ADJ73_13105 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) ADJ73_13115 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) ADJ73_13130 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) ADJ73_13145 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) ADJ73_13155 ENOG4105WH1 Two component transcriptional regulator luxr family ADJ73_13165 ENOG4105CHU acetyl-coa acetyltransferase ADJ73_13170 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ADJ73_13175 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) ADJ73_13180 ENOG4105CKW Inner membrane protein yedI ADJ73_13185 ENOG4105C5Q Transcriptional regulator ADJ73_13190 ENOG4108JU3 Alkyl hydroperoxide reductase ADJ73_13195 ENOG4105D3R alkyl hydroperoxide reductase ADJ73_13200 ENOG4105DGW oligopeptidase A ADJ73_13205 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ADJ73_13210 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone ADJ73_13245 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component ADJ73_13255 ENOG4107QM5 aconitate hydratase ADJ73_13270 ENOG4107VEG TrkA-N domain protein ADJ73_13295 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) ADJ73_13310 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) ADJ73_13315 ENOG4105EN6 Membrane ADJ73_13330 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) ADJ73_13340 ENOG4107W53 thymidine kinase ADJ73_13360 ENOG4105CD5 CoA-binding domain protein ADJ73_13375 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase ADJ73_13380 ENOG4105E98 transcriptional regulator DeoR family ADJ73_13385 ENOG4105DE4 1-phosphofructokinase ADJ73_13390 ENOG4105DM4 PTS System ADJ73_13395 ENOG4105DM4 PTS System ADJ73_13400 ENOG410849S phosphocarrier protein (HPr) ADJ73_13405 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) ADJ73_13410 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) ADJ73_13415 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ADJ73_13425 ENOG4105DVH amino acid ADJ73_13450 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ADJ73_13455 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) ADJ73_13460 ENOG4105C0B DNA polymerase III (alpha subunit) ADJ73_13505 ENOG4105SX7 Transporter ADJ73_13515 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase ADJ73_13555 ENOG4105DKQ ROK family ADJ73_13560 ENOG4105DKQ ROK family ADJ73_13600 ENOG4107S1N anthranilate phosphoribosyltransferase ADJ73_13610 ENOG4105CCU oxidase (Subunit III) ADJ73_13615 ENOG4107UDY cytochrome C ADJ73_13620 ENOG4107EUI c reductase, iron-sulfur ADJ73_13625 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) ADJ73_13640 ENOG41066U0 ADJ73_13650 ENOG4105MCD Part of cytochrome c oxidase, its function is ADJ73_13655 ENOG4105BZ9 Cytochrome C oxidase, subunit I ADJ73_13660 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) ADJ73_13665 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) ADJ73_13685 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ADJ73_13695 ENOG4106371 Methyltransferase ADJ73_13710 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ADJ73_13715 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) ADJ73_13725 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) ADJ73_13730 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase ADJ73_13740 ENOG4105CTK cobaltochelatase, cobn subunit ADJ73_13780 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) ADJ73_13790 ENOG4105CRK lysyL-tRNA synthetase ADJ73_13810 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) ADJ73_13820 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase ADJ73_13825 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) ADJ73_13855 ENOG4108JJB ABC transporter ADJ73_13865 ENOG4108YZT Adenosylcobinamide kinase ADJ73_13880 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) ADJ73_13885 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ADJ73_13925 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) ADJ73_13940 ENOG4105C5F glutamine synthetase ADJ73_13955 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) ADJ73_13960 ENOG4105CI0 Citrate lyase ADJ73_13965 ENOG4105CHY citrate lyase, alpha ADJ73_13975 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase ADJ73_13980 ENOG4107TE5 Lipid kinase ADJ73_13990 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) ADJ73_13995 ENOG4105C5F glutamine synthetase ADJ73_14045 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) ADJ73_14050 ENOG4107XFJ UPF0246 protein ADJ73_14055 ENOG4105CVJ phosphoglycerate mutase ADJ73_14085 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ADJ73_14090 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) ADJ73_14115 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase ADJ73_14130 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ADJ73_14135 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) ADJ73_14190 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) ADJ73_14195 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein ADJ73_14225 ENOG4105YES addiction module antidote protein ADJ73_14235 ENOG4108UZX fmn reductase ADJ73_14275 ENOG4105CDH Citrulline--aspartate ligase ADJ73_14280 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) ADJ73_14285 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) ADJ73_14305 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ADJ73_14310 ENOG4105D4Y metalloprotease ADJ73_14330 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) ADJ73_14340 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) ADJ73_14350 ENOG4107YU2 histidine triad (hIT) protein ADJ73_14365 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ADJ73_14370 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) ADJ73_14395 ENOG4107ZR7 Membrane ADJ73_14415 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) ADJ73_14420 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) ADJ73_14425 ENOG4105F27 Major Facilitator ADJ73_14435 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) ADJ73_14455 ENOG4105C5T Phosphoribosyl pyrophosphate synthase ADJ73_14460 ENOG4105CEY Amp-dependent synthetase and ligase ADJ73_14465 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ADJ73_14490 ENOG410849A acetyltransferase, (GNAT) family ADJ73_14515 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ADJ73_14535 ENOG4105EPD Oligopeptide transporter, Opt family ADJ73_14540 ENOG4107Y49 methyltransferase ADJ73_14545 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) ADJ73_14550 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) ADJ73_14570 ENOG4108594 Permease of the drug metabolite transporter ADJ73_14580 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) ADJ73_14585 ENOG4105DJ2 Major Facilitator Superfamily ADJ73_14600 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ADJ73_14605 ENOG410901E Membrane ADJ73_14610 ENOG4105KC9 Modulates RecA activity (By similarity) ADJ73_14615 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) ADJ73_14635 ENOG4107QRT dEAD DEAH box helicase ADJ73_14650 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) ADJ73_14660 ENOG4105CEV competence damage-inducible protein ADJ73_14670 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) ADJ73_14680 ENOG4107QZI cell division protein FtsK ADJ73_14700 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ADJ73_14705 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) ADJ73_14740 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) ADJ73_14765 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) ADJ73_14770 ENOG4105DZP Membrane-associated zinc metalloprotease ADJ73_14775 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) ADJ73_14790 ENOG4105D38 putrescine abc transporter ADJ73_14795 ENOG4105F38 ABC transporter, permease ADJ73_14810 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ADJ73_14825 ENOG4107T5V SNARE associated Golgi ADJ73_14830 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs ADJ73_14835 ENOG4105KNE Phosphatidate cytidylyltransferase ADJ73_14840 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) ADJ73_14845 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) ADJ73_14850 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) ADJ73_14855 ENOG4105CE9 30S ribosomal protein S2 ADJ73_14875 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ADJ73_14885 ENOG4105C0P Mg chelatase subunit ChlI ADJ73_14890 ENOG41080R2 UPF0102 protein ADJ73_14905 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ADJ73_14910 ENOG4107QYR Signal peptidase i ADJ73_14920 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) ADJ73_14925 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) ADJ73_14930 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) ADJ73_14935 ENOG41082KU UPF0109 protein ADJ73_14940 ENOG4105K5M 30s ribosomal protein S16 ADJ73_14960 ENOG4105DFW ABC transporter ADJ73_14965 ENOG4105CNN ABC, transporter ADJ73_14975 ENOG4105E2R ROK family ADJ73_15005 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) ADJ73_15030 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) ADJ73_15035 ENOG4108375 Acylphosphatase (EC 3.6.1.7) ADJ73_15055 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) ADJ73_15065 ENOG41084BZ 50S ribosomal protein L32 ADJ73_15075 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) ADJ73_15080 ENOG4106H78 methyltransferase ADJ73_15095 ENOG4105VB9 50S ribosomal protein l28 ADJ73_15140 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase ADJ73_15150 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) ADJ73_15155 ENOG4107R3E Citrate transporter ADJ73_15160 ENOG4105K70 DNA-binding protein ADJ73_15165 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ADJ73_15170 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ADJ73_15180 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ADJ73_15190 ENOG4105CYC Transferase ADJ73_15220 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) ADJ73_15225 ENOG4107JBM CrcB-like protein ADJ73_15230 ENOG41083TI Protein CrcB homolog ADJ73_15235 ENOG4105ERH Fumarylacetoacetate hydrolase ADJ73_15250 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ADJ73_15255 ENOG4108Z86 Glutamine amidotransferase ADJ73_15260 ENOG4105CHR reductase ADJ73_15265 ENOG4105C26 Dehydrogenase ADJ73_15285 ENOG4105CM2 brancheD-chain amino acid aminotransferase ADJ73_15290 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ADJ73_15300 ENOG4105EM7 Selenocysteine-specific translation elongation factor ADJ73_15305 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) ADJ73_15330 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) ADJ73_15355 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ADJ73_15360 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ADJ73_15365 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ADJ73_15385 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase ADJ73_15410 ENOG4105ECB domain protein ADJ73_15410 ENOG4105ECB domain protein ADJ73_15450 ENOG4105CH2 amidohydrolase ADJ73_15460 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) ADJ73_15465 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) ADJ73_15470 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) ADJ73_15475 ENOG4105CK7 Sodium proline symporter ADJ73_15480 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) ADJ73_15490 ENOG4108Q5Y Membrane ADJ73_15500 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) ADJ73_15515 ENOG4106032 Glutathionylspermidine synthase ADJ73_15525 ENOG4105C10 Electron transfer flavoprotein ADJ73_15555 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) ADJ73_15560 ENOG4105CG3 alpha amylase, catalytic region ADJ73_15580 ENOG4105ECY inositol monophosphatase ADJ73_15585 ENOG4105KEG ribosomal-protein-alanine acetyltransferase ADJ73_15610 ENOG4105D5P Methylmalonyl-coA mutase ADJ73_15635 ENOG4105CHU acetyl-coa acetyltransferase ADJ73_15680 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ADJ73_15685 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) ADJ73_15700 ENOG4105RFZ Methylmalonyl-coA mutase ADJ73_15720 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) ADJ73_15740 ENOG4105K64 Glycosyl transferase, family 2 ADJ73_15750 ENOG4107RA4 Glycosyl transferase (Group 1 ADJ73_15755 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) ADJ73_15760 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) ADJ73_15765 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) ADJ73_15770 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ADJ73_15775 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) ADJ73_15780 ENOG4106DE0 ATP synthase ADJ73_15785 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) ADJ73_15800 ENOG4105ESV Glycosyl transferase, family 4 ADJ73_15805 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ADJ73_15815 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ADJ73_15820 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) ADJ73_15825 ENOG4105VFB Binds the 23S rRNA (By similarity) ADJ73_15835 ENOG4107QJZ Glycosyl transferase, family 2 ADJ73_15855 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) ADJ73_15860 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) ADJ73_15865 ENOG4105D6E homoserine dehydrogenase ADJ73_15870 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ADJ73_15880 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ADJ73_15910 ENOG4105JFG SpoIID LytB domain protein ADJ73_15925 ENOG4105EY8 ABC transporter ADJ73_15935 ENOG410602S Transferase ADJ73_15955 ENOG4108KGH TRANSCRIPTIONal ADJ73_15960 ENOG4108RYC glycosyltransferase ADJ73_15965 ENOG4108MKI Glycosyl transferase, family 2 ADJ73_15985 ENOG4105CG3 alpha amylase, catalytic region ADJ73_15990 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) ADJ73_16000 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) ADJ73_16020 ENOG4105E39 Enoyl-CoA hydratase ADJ73_16035 ENOG4105D8K carboxyl transferase ADJ73_16050 ENOG4105EEQ Na H antiporter ADJ73_16055 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 ADJ73_16060 ENOG4107WR6 Maf-like protein ADJ73_16065 ENOG4107TXC Transcriptional regulator ADJ73_16070 ENOG4107QX3 carboxylase ADJ73_16075 ENOG4105C1G acyl-Coa dehydrogenase ADJ73_16090 ENOG4105C0F tryptophanase EC 4.1.99.1 ADJ73_16100 ENOG4108JIK carboxylase ADJ73_16105 ENOG4107R7Y intracellular protease Pfpi family ADJ73_16130 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain ADJ73_16150 ENOG4108WQ6 secreted protein ADJ73_16155 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ADJ73_16175 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) ADJ73_16185 ENOG4108Z2K Cupin 2, conserved barrel domain protein ADJ73_16195 ENOG4105C87 Aminotransferase class I and II ADJ73_16205 ENOG4105DKK Benzoate ADJ73_16255 ENOG4105UIB (ABC) transporter ADJ73_16260 ENOG4108JQ9 ABC transporter ADJ73_16265 ENOG4105DIH basic membrane ADJ73_16270 ENOG4105CH2 amidohydrolase ADJ73_16290 ENOG4105DZ1 carboxypeptidase ADJ73_16300 ENOG4105C31 Tryptophanyl-tRNA synthetase ADJ73_16310 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) ADJ73_16335 ENOG4105E9K Isocitrate dehydrogenase ADJ73_16365 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ADJ73_16385 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) ADJ73_16395 ENOG4105DC1 bifunctional purine biosynthesis protein purh ADJ73_16420 ENOG4105CMV Succinyl-CoA synthetase subunit beta