locus-tag	class	description
LDL57_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LDL57_00010	COG0592	DNA-directed DNA polymerase activity
LDL57_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LDL57_00020	COG0187	DNA topoisomerase II activity
LDL57_00025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LDL57_00030	COG1649	PFAM Uncharacterised BCR, COG1649
LDL57_00035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LDL57_00040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LDL57_00045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LDL57_00050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LDL57_00060	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LDL57_00065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LDL57_00080	COG0356	it plays a direct role in the translocation of protons across the membrane
LDL57_00090	COG0357	Ribosomal RNA small subunit methyltransferase G
LDL57_00095	COG0445	tRNA wobble uridine modification
LDL57_00100	COG0716	FMN binding
LDL57_00105	COG1522	sequence-specific DNA binding
LDL57_00110	COG2502	aspartate--ammonia ligase
LDL57_00115	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LDL57_00120	COG0714	Associated with various cellular activities
LDL57_00155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDL57_00160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LDL57_00165	COG0180	Tryptophanyl-tRNA synthetase
LDL57_00170	COG0546	phosphoglycolate phosphatase activity
LDL57_00175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LDL57_00190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LDL57_00200	COG4796	Type ii and iii secretion system protein
LDL57_00220	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LDL57_00225	COG0494	nUDIX hydrolase
LDL57_00235	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LDL57_00240	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LDL57_00245	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LDL57_00250	COG2081	HI0933 family
LDL57_00255	COG0306	phosphate transporter
LDL57_00265	COG0589	response to stress
LDL57_00270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LDL57_00285	COG4934	collagen metabolic process
LDL57_00290	COG0742	ribosomal rna small subunit methyltransferase
LDL57_00325	COG0300	oxidoreductase activity
LDL57_00325	COG0318	PFAM AMP-dependent synthetase and ligase
LDL57_00325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LDL57_00325	COG1028	Short-chain dehydrogenase reductase Sdr
LDL57_00325	COG3321	synthase
LDL57_00360	COG1396	sequence-specific DNA binding
LDL57_00370	COG2205	protein histidine kinase activity
LDL57_00370	COG2198	Histidine kinase
LDL57_00370	COG0784	Response regulator, receiver
LDL57_00370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDL57_00375	COG2197	response regulator
LDL57_00380	COG3678	ATP-independent chaperone mediated protein folding
LDL57_00385	COG0745	RESPONSE REGULATOR receiver
LDL57_00390	COG2205	protein histidine kinase activity
LDL57_00405	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LDL57_00405	COG0473	3-isopropylmalate dehydrogenase activity
LDL57_00460	COG0562	UDP-galactopyranose mutase
LDL57_00465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDL57_00470	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LDL57_00475	COG1045	serine acetyltransferase
LDL57_00480	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LDL57_00490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LDL57_00495	COG4942	peptidase
LDL57_00500	COG2861	carbohydrate metabolic process
LDL57_00505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDL57_00510	COG0859	PFAM glycosyl transferase family 9
LDL57_00515	COG0859	PFAM glycosyl transferase family 9
LDL57_00525	COG1519	Transferase
LDL57_00530	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LDL57_00535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LDL57_00555	COG0515	serine threonine protein kinase
LDL57_00560	COG0438	transferase activity, transferring glycosyl groups
LDL57_00565	COG0859	PFAM glycosyl transferase family 9
LDL57_00570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LDL57_00575	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LDL57_00585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LDL57_00590	COG0756	dUTP diphosphatase activity
LDL57_00595	COG1309	transcriptional regulator
LDL57_00600	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LDL57_00605	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LDL57_00610	COG1561	YicC-like family, N-terminal region
LDL57_00625	COG0205	6-phosphofructokinase activity
LDL57_00630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LDL57_00635	COG1349	DNA-binding transcription factor activity
LDL57_00640	COG0705	Rhomboid family
LDL57_00645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LDL57_00650	COG0316	Belongs to the HesB IscA family
LDL57_00650	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LDL57_00655	COG1040	competence protein
LDL57_00675	COG0596	Alpha beta hydrolase
LDL57_00690	COG1918	ferrous iron import across plasma membrane
LDL57_00695	COG2183	response to ionizing radiation
LDL57_00700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LDL57_00715	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LDL57_00720	COG0573	inorganic phosphate transmembrane transporter activity
LDL57_00725	COG0581	inorganic phosphate transmembrane transporter activity
LDL57_00730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LDL57_00735	COG0704	Plays a role in the regulation of phosphate uptake
LDL57_00740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDL57_00745	COG0765	amino acid transport
LDL57_00750	COG0765	amino acid transport
LDL57_00755	COG2252	PERMEase
LDL57_00760	COG3078	GTPase activator activity
LDL57_00765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LDL57_00775	COG3852	Histidine kinase
LDL57_00785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDL57_00795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDL57_00805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LDL57_00810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LDL57_00845	COG0583	DNA-binding transcription factor activity
LDL57_00850	COG3085	chromosome segregation
LDL57_00855	COG0606	chelatase, subunit chli
LDL57_00870	COG3978	acetolactate synthase activity
LDL57_00880	COG0129	dihydroxy-acid dehydratase activity
LDL57_00895	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LDL57_00915	COG0210	DNA helicase
LDL57_00920	COG0248	Ppx GppA phosphatase
LDL57_00925	COG0513	Belongs to the DEAD box helicase family
LDL57_00930	COG3118	belongs to the thioredoxin family
LDL57_00940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LDL57_00945	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
LDL57_00950	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LDL57_00955	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LDL57_00960	COG1088	dTDP-glucose 4,6-dehydratase activity
LDL57_00965	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LDL57_00970	COG0456	acetyltransferase
LDL57_00975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LDL57_00980	COG2244	polysaccharide biosynthetic process
LDL57_00985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LDL57_00995	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LDL57_01025	COG3071	HemY protein
LDL57_01030	COG2959	enzyme of heme biosynthesis
LDL57_01035	COG1587	Uroporphyrinogen-III synthase
LDL57_01040	COG0181	hydroxymethylbilane synthase activity
LDL57_01050	COG1965	Belongs to the frataxin family
LDL57_01060	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LDL57_01065	COG3159	Protein conserved in bacteria
LDL57_01075	COG1011	Hydrolase
LDL57_01080	COG0210	DNA helicase
LDL57_01085	COG0598	Magnesium transport protein CorA
LDL57_01100	COG2267	carboxylic ester hydrolase activity
LDL57_01105	COG0561	phosphatase activity
LDL57_01115	COG3264	Mechanosensitive ion channel
LDL57_01115	COG1511	domain protein
LDL57_01120	COG0688	phosphatidylethanolamine metabolic process
LDL57_01125	COG1162	GTPase activity
LDL57_01130	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LDL57_01140	COG0802	atpase or kinase
LDL57_01145	COG0860	N-Acetylmuramoyl-L-alanine amidase
LDL57_01150	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LDL57_01155	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LDL57_01160	COG1923	regulation of RNA biosynthetic process
LDL57_01165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LDL57_01170	COG0330	HflC and HflK could
LDL57_01175	COG0330	HflC and HflK could
LDL57_01180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LDL57_01185	COG1959	2 iron, 2 sulfur cluster binding
LDL57_01190	COG0557	exoribonuclease II activity
LDL57_01195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDL57_01205	COG0360	Binds together with S18 to 16S ribosomal RNA
LDL57_01210	COG2965	DNA replication, synthesis of RNA primer
LDL57_01215	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LDL57_01220	COG0359	binds to the 23S rRNA
LDL57_01225	COG0545	Peptidyl-prolyl cis-trans isomerase
LDL57_01235	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LDL57_01245	COG3590	peptidase
LDL57_01250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LDL57_01255	COG0729	surface antigen
LDL57_01260	COG2911	Protein conserved in bacteria
LDL57_01265	COG2105	PFAM AIG2 family protein
LDL57_01275	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LDL57_01280	COG1438	arginine binding
LDL57_01285	COG0039	L-malate dehydrogenase activity
LDL57_01290	COG3423	Transcriptional regulator
LDL57_01300	COG0142	geranyltranstransferase activity
LDL57_01305	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LDL57_01315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LDL57_01320	COG2027	D-alanyl-D-alanine carboxypeptidase
LDL57_01330	COG1534	Rna-binding protein
LDL57_01335	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LDL57_01345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LDL57_01350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDL57_01355	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LDL57_01370	COG0779	Required for maturation of 30S ribosomal subunits
LDL57_01375	COG0195	Participates in both transcription termination and antitermination
LDL57_01380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LDL57_01385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LDL57_01390	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LDL57_01415	COG0513	Belongs to the DEAD box helicase family
LDL57_01425	COG3210	domain, Protein
LDL57_01450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDL57_01465	COG0826	peptidase U32
LDL57_01470	COG0826	peptidase U32
LDL57_01475	COG3154	lipid carrier protein
LDL57_01480	COG3153	acetyltransferase
LDL57_01485	COG2827	Endonuclease containing a URI domain
LDL57_01500	COG0602	queuosine metabolic process
LDL57_01515	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LDL57_01525	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
LDL57_01530	COG0525	valine-tRNA ligase activity
LDL57_01535	COG2927	DNA polymerase III (CHI subunit)
LDL57_01540	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LDL57_01545	COG0795	lipopolysaccharide-transporting ATPase activity
LDL57_01550	COG0795	lipopolysaccharide-transporting ATPase activity
LDL57_01555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LDL57_01605	COG4790	Type iii secretion
LDL57_01650	COG2207	Transcriptional regulator
LDL57_01725	COG1715	Restriction endonuclease
LDL57_01735	COG2252	PERMEase
LDL57_01740	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LDL57_01740	COG2080	2 iron, 2 sulfur cluster binding
LDL57_01745	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LDL57_01750	COG0402	S-adenosylhomocysteine deaminase activity
LDL57_01760	COG2068	MobA-Related Protein
LDL57_01765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LDL57_01770	COG3608	succinylglutamate desuccinylase aspartoacylase
LDL57_01770	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LDL57_01775	COG0549	Belongs to the carbamate kinase family
LDL57_01785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDL57_01790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LDL57_01805	COG2080	2 iron, 2 sulfur cluster binding
LDL57_01810	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LDL57_01815	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LDL57_01820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LDL57_01825	COG2011	ABC-type metal ion transport system permease component
LDL57_01835	COG1464	Belongs to the NlpA lipoprotein family
LDL57_01930	COG2197	response regulator
LDL57_01935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDL57_01935	COG2205	protein histidine kinase activity
LDL57_01940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDL57_01940	COG2205	protein histidine kinase activity
LDL57_02135	COG2814	Major facilitator Superfamily
LDL57_02140	COG2239	Acts as a magnesium transporter
LDL57_02150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LDL57_02150	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LDL57_02150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LDL57_02155	COG1105	Belongs to the carbohydrate kinase PfkB family
LDL57_02160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDL57_02160	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDL57_02190	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LDL57_02295	COG4695	Portal protein
LDL57_02340	COG4974	Belongs to the 'phage' integrase family
LDL57_02390	COG0335	large ribosomal subunit rRNA binding
LDL57_02400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LDL57_02410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LDL57_02415	COG4137	Cytochrome C assembly protein
LDL57_02420	COG4536	flavin adenine dinucleotide binding
LDL57_02430	COG2918	glutathione biosynthetic process
LDL57_02450	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LDL57_02455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LDL57_02460	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LDL57_02470	COG2814	Major facilitator Superfamily
LDL57_02485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LDL57_02490	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LDL57_02505	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LDL57_02510	COG2195	Cleaves the N-terminal amino acid of tripeptides
LDL57_02515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LDL57_02530	COG2991	Protein conserved in bacteria
LDL57_02535	COG1477	protein flavinylation
LDL57_02545	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LDL57_02550	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LDL57_02555	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LDL57_02560	COG1805	sodium ion transport
LDL57_02565	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LDL57_02570	COG3034	peptidoglycan biosynthetic process
LDL57_02575	COG0121	glutamine amidotransferase
LDL57_02585	COG1960	acyl-CoA dehydrogenase activity
LDL57_02595	COG0583	DNA-binding transcription factor activity
LDL57_02605	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LDL57_02620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LDL57_02625	COG0189	ligase activity
LDL57_02630	COG1678	Uncharacterized ACR, COG1678
LDL57_02640	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LDL57_02645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LDL57_02650	COG0762	integral membrane protein
LDL57_02655	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LDL57_02660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LDL57_02675	COG2066	Belongs to the glutaminase family
LDL57_02680	COG3171	Protein conserved in bacteria
LDL57_02685	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LDL57_02690	COG1194	a g-specific adenine glycosylase
LDL57_02695	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LDL57_02700	COG0741	lytic transglycosylase activity
LDL57_02765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LDL57_02770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LDL57_02775	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LDL57_02780	COG1063	alcohol dehydrogenase
LDL57_02785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDL57_02790	COG2223	nitrite transmembrane transporter activity
LDL57_02795	COG1621	beta-fructofuranosidase activity
LDL57_02955	COG3710	Transcriptional regulator
LDL57_02955	COG0457	Tetratricopeptide repeat
LDL57_02965	COG1757	Na H antiporter
LDL57_02970	COG0113	porphobilinogen synthase activity
LDL57_02975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LDL57_02980	COG1151	hydroxylamine reductase activity
LDL57_03000	COG1301	dicarboxylic acid transport
LDL57_03035	COG1012	belongs to the aldehyde dehydrogenase family
LDL57_03050	COG0252	asparaginase activity
LDL57_03070	COG0126	phosphoglycerate kinase activity
LDL57_03075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LDL57_03080	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LDL57_03090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LDL57_03095	COG0328	RNA-DNA hybrid ribonuclease activity
LDL57_03100	COG2226	methyltransferase
LDL57_03105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDL57_03110	COG0741	lytic transglycosylase activity
LDL57_03110	COG1388	LysM domain
LDL57_03120	COG3064	Membrane
LDL57_03120	COG3210	domain, Protein
LDL57_03120	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
LDL57_03125	COG0148	phosphopyruvate hydratase activity
LDL57_03130	COG0504	CTP synthase activity
LDL57_03135	COG3956	TIGRFAM MazG family protein
LDL57_03140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LDL57_03145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LDL57_03155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LDL57_03160	COG0316	Belongs to the HesB IscA family
LDL57_03165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LDL57_03170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDL57_03175	COG1489	DNA binding
LDL57_03180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LDL57_03185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDL57_03195	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LDL57_03200	COG0842	Transport permease protein
LDL57_03205	COG1131	(ABC) transporter
LDL57_03210	COG0288	reversible hydration of carbon dioxide
LDL57_03220	COG2132	Multicopper oxidase
LDL57_03230	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LDL57_03235	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LDL57_03245	COG5441	Belongs to the UPF0261 family
LDL57_03250	COG5564	TIM-barrel signal transduction protein
LDL57_03255	COG0534	Mate efflux family protein
LDL57_03260	COG0523	cobalamin synthesis protein
LDL57_03265	COG2879	small protein
LDL57_03270	COG1966	Carbon starvation protein
LDL57_03280	COG3188	usher protein
LDL57_03285	COG3121	Chaperone
LDL57_03300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LDL57_03310	COG1982	Orn Lys Arg decarboxylase major
LDL57_03340	COG1203	CRISPR-associated helicase, Cas3
LDL57_03380	COG2771	luxR family
LDL57_03430	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LDL57_03445	COG1388	LysM domain
LDL57_03445	COG4942	peptidase
LDL57_03450	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LDL57_03455	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LDL57_03460	COG0585	pseudouridine synthase activity
LDL57_03465	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LDL57_03470	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LDL57_03480	COG0720	synthase
LDL57_03485	COG0602	queuosine metabolic process
LDL57_03495	COG3021	interspecies interaction between organisms
LDL57_03530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LDL57_03535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LDL57_03555	COG1720	tRNA m6t6A37 methyltransferase activity
LDL57_03560	COG0442	prolyl-tRNA aminoacylation
LDL57_03565	COG3015	lipoprotein NlpE involved in copper resistance
LDL57_03570	COG4568	rho-dependent transcription termination
LDL57_03575	COG0037	tRNA processing
LDL57_03585	COG0825	malonyl-CoA metabolic process
LDL57_03595	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LDL57_03600	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LDL57_03605	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LDL57_03610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LDL57_03615	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LDL57_03620	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
LDL57_03625	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LDL57_03630	COG0750	zinc metalloprotease
LDL57_03635	COG0575	Belongs to the CDS family
LDL57_03640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LDL57_03645	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LDL57_03650	COG0233	cytoplasmic translational termination
LDL57_03655	COG0528	UMP kinase activity
LDL57_03660	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LDL57_03675	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LDL57_03690	COG0564	pseudouridine synthase activity
LDL57_03710	COG1611	Belongs to the LOG family
LDL57_03715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LDL57_03730	COG0583	DNA-binding transcription factor activity
LDL57_03735	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LDL57_03775	COG0860	N-Acetylmuramoyl-L-alanine amidase
LDL57_03780	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LDL57_03780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LDL57_03790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LDL57_03795	COG1074	ATP-dependent DNA helicase activity
LDL57_03800	COG1025	Belongs to the peptidase M16 family
LDL57_03805	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LDL57_03820	COG4795	General secretion pathway protein
LDL57_03830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LDL57_03835	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LDL57_03840	COG0494	nUDIX hydrolase
LDL57_03845	COG4143	(ABC) transporter
LDL57_03850	COG1178	ABC-type Fe3 transport system permease component
LDL57_03855	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LDL57_03860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LDL57_03870	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LDL57_03875	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LDL57_03880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LDL57_03885	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LDL57_03890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LDL57_03895	COG2967	ApaG domain
LDL57_03900	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LDL57_03910	COG2132	Multicopper oxidase
LDL57_03915	COG0204	Acyl-transferase
LDL57_03920	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LDL57_03930	COG3150	esterase
LDL57_03955	COG0494	nUDIX hydrolase
LDL57_03965	COG5463	Belongs to the UPF0441 family
LDL57_03970	COG0754	glutathionylspermidine amidase activity
LDL57_03975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDL57_03985	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LDL57_03985	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LDL57_03990	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LDL57_03995	COG3025	triphosphatase activity
LDL57_04000	COG4991	sh3 domain protein
LDL57_04005	COG0617	tRNA 3'-terminal CCA addition
LDL57_04010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LDL57_04015	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LDL57_04020	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LDL57_04030	COG0358	DNA primase activity
LDL57_04040	COG4974	Belongs to the 'phage' integrase family
LDL57_04095	COG4695	Portal protein
LDL57_04215	COG2944	sequence-specific DNA binding
LDL57_04245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LDL57_04250	COG2867	negative regulation of translational initiation
LDL57_04255	COG2914	Belongs to the UPF0125 (RnfH) family
LDL57_04260	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LDL57_04265	COG0497	DNA recombination
LDL57_04270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LDL57_04275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LDL57_04280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LDL57_04285	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
LDL57_04290	COG0513	Belongs to the DEAD box helicase family
LDL57_04295	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LDL57_04310	COG3026	antisigma factor binding
LDL57_04315	COG3086	response to oxidative stress
LDL57_04330	COG0571	ribonuclease III activity
LDL57_04335	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LDL57_04345	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LDL57_04355	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LDL57_04360	COG2194	sulfuric ester hydrolase activity
LDL57_04370	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LDL57_04375	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LDL57_04375	COG0047	phosphoribosylformylglycinamidine synthase activity
LDL57_04380	COG2205	protein histidine kinase activity
LDL57_04385	COG3170	Tfp pilus assembly protein FimV
LDL57_04390	COG2204	response regulator
LDL57_04395	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LDL57_04395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LDL57_04400	COG0347	Belongs to the P(II) protein family
LDL57_04405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDL57_04405	COG1017	nitric oxide dioxygenase activity
LDL57_04410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LDL57_04415	COG2814	Major facilitator Superfamily
LDL57_04430	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LDL57_04435	COG1959	2 iron, 2 sulfur cluster binding
LDL57_04440	COG1104	cysteine desulfurase activity
LDL57_04445	COG0822	iron-sulfur transferase activity
LDL57_04450	COG0316	Belongs to the HesB IscA family
LDL57_04465	COG0633	Ferredoxin
LDL57_04470	COG2975	iron-sulfur cluster assembly
LDL57_04475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LDL57_04485	COG0105	UTP biosynthetic process
LDL57_04490	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LDL57_04500	COG1426	Protein conserved in bacteria
LDL57_04505	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LDL57_04510	COG0124	histidyl-tRNA synthetase
LDL57_04515	COG2976	Protein conserved in bacteria
LDL57_04520	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LDL57_04525	COG1160	GTP binding
LDL57_04550	COG0456	acetyltransferase
LDL57_04560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LDL57_04565	COG2190	(PTS) system
LDL57_04570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDL57_04575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDL57_04580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LDL57_04590	COG3115	cell septum assembly
LDL57_04595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LDL57_04600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LDL57_04605	COG3530	Putative quorum-sensing-regulated virulence factor
LDL57_04615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDL57_04650	COG1652	LysM domain
LDL57_04655	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LDL57_04655	COG1013	pyruvate-flavodoxin oxidoreductase activity
LDL57_04655	COG0674	pyruvate-flavodoxin oxidoreductase activity
LDL57_04655	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDL57_04695	COG1177	transmembrane transport
LDL57_04730	COG0183	Belongs to the thiolase family
LDL57_04735	COG1024	Enoyl-CoA hydratase
LDL57_04735	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDL57_04740	COG2062	phosphohistidine phosphatase, SixA
LDL57_04745	COG2840	Smr protein MutS2
LDL57_04755	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LDL57_04775	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LDL57_04775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDL57_04780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LDL57_04785	COG0697	spore germination
LDL57_04795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDL57_04800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LDL57_04805	COG0101	tRNA pseudouridine synthase activity
LDL57_04810	COG0586	Pfam SNARE associated Golgi protein
LDL57_04815	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LDL57_04820	COG0285	dihydrofolate synthase activity
LDL57_04825	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LDL57_04830	COG1286	toxin biosynthetic process
LDL57_04835	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LDL57_04840	COG0163	prenyltransferase activity
LDL57_04845	COG1090	epimerase
LDL57_04850	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LDL57_04900	COG0857	belongs to the CobB CobQ family
LDL57_04900	COG0280	phosphate acetyltransferase
LDL57_04905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LDL57_04910	COG3092	negative regulation of chromosome organization
LDL57_04915	COG3013	Belongs to the UPF0304 family
LDL57_04920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDL57_04930	COG0582	viral genome integration into host DNA
LDL57_04975	COG3561	AntA/AntB antirepressor
LDL57_05015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LDL57_05060	COG0305	Participates in initiation and elongation during chromosome replication
LDL57_05095	COG3617	BRO family, N-terminal domain
LDL57_05120	COG3772	lysozyme
LDL57_05310	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LDL57_05320	COG3646	Phage regulatory protein
LDL57_05335	COG0436	Aminotransferase
LDL57_05340	COG0583	DNA-binding transcription factor activity
LDL57_05345	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDL57_05350	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDL57_05355	COG0649	NAD binding
LDL57_05355	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDL57_05380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDL57_05385	COG0839	Belongs to the complex I subunit 6 family
LDL57_05395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LDL57_05400	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDL57_05410	COG1169	isochorismate synthase
LDL57_05415	COG1169	isochorismate synthase
LDL57_05420	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LDL57_05425	COG0596	Alpha beta hydrolase
LDL57_05435	COG1441	menaquinone biosynthetic process
LDL57_05455	COG0814	amino acid
LDL57_05460	COG2226	methyltransferase
LDL57_05465	COG0633	Ferredoxin
LDL57_05480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LDL57_05490	COG2205	protein histidine kinase activity
LDL57_05490	COG0784	Response regulator, receiver
LDL57_05495	COG2197	response regulator
LDL57_05500	COG2198	Histidine kinase
LDL57_05500	COG0642	Histidine kinase
LDL57_05545	COG3083	sulfuric ester hydrolase activity
LDL57_05555	COG3081	Nucleoid-associated protein
LDL57_05670	COG3772	lysozyme
LDL57_05710	COG4695	Portal protein
LDL57_05795	COG4974	Belongs to the 'phage' integrase family
LDL57_05800	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LDL57_05805	COG1061	Type III restriction enzyme res subunit
LDL57_05810	COG1187	pseudouridine synthase activity
LDL57_05815	COG2814	Major facilitator Superfamily
LDL57_05825	COG0791	NLP P60 protein
LDL57_05840	COG0814	amino acid
LDL57_05845	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LDL57_05850	COG2855	membrane
LDL57_05855	COG0583	DNA-binding transcription factor activity
LDL57_05860	COG0833	amino acid
LDL57_05875	COG1120	ATPase activity
LDL57_05880	COG4771	TonB-dependent receptor
LDL57_05890	COG0531	amino acid
LDL57_05895	COG2925	Exonuclease
LDL57_05900	COG2926	Belongs to the UPF0265 family
LDL57_05910	COG1530	ribonuclease E activity
LDL57_05915	COG0564	pseudouridine synthase activity
LDL57_05920	COG0424	maF-like protein
LDL57_05925	COG1399	metal-binding, possibly nucleic acid-binding protein
LDL57_05930	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LDL57_05935	COG0416	fatty acid biosynthetic process
LDL57_05940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDL57_05945	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LDL57_05950	COG1028	Short-chain dehydrogenase reductase Sdr
LDL57_05960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LDL57_05965	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LDL57_05970	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LDL57_05975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LDL57_05980	COG0470	DNA polymerase III
LDL57_05985	COG0084	hydrolase, TatD family'
LDL57_05990	COG0537	adenosine 5'-monophosphoramidase activity
LDL57_05995	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
LDL57_06005	COG1472	Belongs to the glycosyl hydrolase 3 family
LDL57_06020	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
LDL57_06020	COG1073	alpha beta
LDL57_06020	COG3064	Membrane
LDL57_06075	COG1252	NADH dehydrogenase
LDL57_06080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LDL57_06085	COG4591	ABC-type transport system involved in lipoprotein release permease component
LDL57_06090	COG1136	(ABC) transporter
LDL57_06095	COG4591	ABC-type transport system involved in lipoprotein release permease component
LDL57_06110	COG2850	peptidyl-arginine hydroxylation
LDL57_06120	COG0745	RESPONSE REGULATOR receiver
LDL57_06125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LDL57_06130	COG2915	High frequency lysogenization protein hflD homolog
LDL57_06135	COG0482	sulfurtransferase activity
LDL57_06150	COG0538	isocitrate dehydrogenase activity
LDL57_06155	COG0582	viral genome integration into host DNA
LDL57_06280	COG0305	Participates in initiation and elongation during chromosome replication
LDL57_06335	COG3772	lysozyme
LDL57_06365	COG3728	DNA packaging
LDL57_06365	COG5484	DNA packaging
LDL57_06460	COG0675	Transposase, IS605 OrfB family
LDL57_06515	COG3617	BRO family, N-terminal domain
LDL57_06535	COG3023	N-Acetylmuramoyl-L-alanine amidase
LDL57_06565	COG1115	amino acid carrier protein
LDL57_06575	COG2207	Transcriptional regulator
LDL57_06575	COG3708	Transcriptional regulator
LDL57_06585	COG1113	amino acid transport
LDL57_06625	COG2197	response regulator
LDL57_06630	COG0322	excinuclease ABC activity
LDL57_06635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LDL57_06730	COG0305	Participates in initiation and elongation during chromosome replication
LDL57_06735	COG0305	Participates in initiation and elongation during chromosome replication
LDL57_06780	COG3772	lysozyme
LDL57_06850	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
LDL57_06860	COG3077	Addiction module antitoxin, RelB DinJ family
LDL57_06925	COG3646	Phage regulatory protein
LDL57_07060	COG1830	Aldolase
LDL57_07065	COG0826	peptidase U32
LDL57_07070	COG0745	RESPONSE REGULATOR receiver
LDL57_07075	COG2205	protein histidine kinase activity
LDL57_07080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LDL57_07085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LDL57_07090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDL57_07105	COG0477	Major facilitator Superfamily
LDL57_07110	COG2239	Acts as a magnesium transporter
LDL57_07115	COG0248	Ppx GppA phosphatase
LDL57_07120	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LDL57_07130	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LDL57_07135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LDL57_07140	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LDL57_07150	COG2233	PERMEase
LDL57_07155	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LDL57_07160	COG1393	Belongs to the ArsC family
LDL57_07165	COG4783	chaperone-mediated protein folding
LDL57_07175	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LDL57_07185	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LDL57_07190	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LDL57_07195	COG2321	neutral zinc metallopeptidase
LDL57_07200	COG2707	UPF0756 membrane protein
LDL57_07205	COG1444	tRNA N-acetyltransferase activity
LDL57_07215	COG2832	Protein of unknown function (DUF454)
LDL57_07220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDL57_07225	COG1393	Belongs to the ArsC family
LDL57_07230	COG2197	response regulator
LDL57_07235	COG0281	malic enzyme
LDL57_07235	COG0280	phosphate acetyltransferase
LDL57_07240	COG1770	oligopeptidase
LDL57_07245	COG1570	exodeoxyribonuclease VII activity
LDL57_07255	COG0517	IMP dehydrogenase activity
LDL57_07255	COG0516	GMP reductase activity
LDL57_07260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LDL57_07260	COG0519	Catalyzes the synthesis of GMP from XMP
LDL57_07265	COG3397	chitin binding
LDL57_07275	COG0433	COG0433 Predicted ATPase
LDL57_07280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LDL57_07290	COG0574	Belongs to the PEP-utilizing enzyme family
LDL57_07290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDL57_07295	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LDL57_07300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDL57_07305	COG4558	Periplasmic binding protein
LDL57_07310	COG3720	iron ion transport
LDL57_07325	COG0628	permease
LDL57_07335	COG2050	protein possibly involved in aromatic compounds catabolism
LDL57_07340	COG0316	Belongs to the HesB IscA family
LDL57_07345	COG0719	Fe-S assembly protein
LDL57_07350	COG0396	ATPase activity
LDL57_07355	COG0719	Fe-S assembly protein
LDL57_07360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LDL57_07365	COG2166	iron-sulfur cluster assembly
LDL57_07370	COG1376	ErfK ybiS ycfS ynhG family protein
LDL57_07370	COG1388	LysM domain
LDL57_07375	COG4238	major outer membrane lipoprotein
LDL57_07380	COG0469	pyruvate kinase activity
LDL57_07395	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LDL57_07400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LDL57_07405	COG0346	lactoylglutathione lyase activity
LDL57_07425	COG0259	pyridoxamine-phosphate oxidase activity
LDL57_07435	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LDL57_07445	COG3422	double-strand break repair
LDL57_07475	COG4172	Belongs to the ABC transporter superfamily
LDL57_07480	COG4172	Belongs to the ABC transporter superfamily
LDL57_07485	COG4171	peptide transport system, permease
LDL57_07490	COG4168	peptide transport system, permease
LDL57_07500	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LDL57_07505	COG1842	Phage shock protein A
LDL57_07515	COG1983	PspC domain protein
LDL57_07525	COG3106	COG3106 Predicted ATPase
LDL57_07555	COG0598	Magnesium transport protein CorA
LDL57_07570	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LDL57_07575	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LDL57_07580	COG2186	Transcriptional regulator
LDL57_07595	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDL57_07600	COG3139	Protein of unknown function (DUF1315)
LDL57_07605	COG1335	isochorismatase
LDL57_07610	COG0252	asparaginase activity
LDL57_07615	COG0616	signal peptide processing
LDL57_07620	COG0778	Nitroreductase
LDL57_07625	COG0709	Synthesizes selenophosphate from selenide and ATP
LDL57_07635	COG0708	Exodeoxyribonuclease III
LDL57_07640	COG0583	DNA-binding transcription factor activity
LDL57_07645	COG0788	formyltetrahydrofolate deformylase activity
LDL57_07650	COG0745	RESPONSE REGULATOR receiver
LDL57_07655	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LDL57_07665	COG1435	thymidine kinase activity
LDL57_07670	COG1454	alcohol dehydrogenase
LDL57_07670	COG1012	belongs to the aldehyde dehydrogenase family
LDL57_07675	COG2095	MarC family integral membrane protein
LDL57_07680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LDL57_07685	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LDL57_07695	COG2917	probably involved in intracellular septation
LDL57_07710	COG0159	tryptophan synthase activity
LDL57_07715	COG0133	tryptophan synthase activity
LDL57_07720	COG0134	indole-3-glycerol-phosphate synthase activity
LDL57_07720	COG0135	phosphoribosylanthranilate isomerase activity
LDL57_07725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LDL57_07725	COG0512	Glutamine amidotransferase of anthranilate synthase
LDL57_07730	COG0512	Glutamine amidotransferase of anthranilate synthase
LDL57_07730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LDL57_07735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LDL57_07740	COG0613	PHP domain protein
LDL57_07745	COG0009	L-threonylcarbamoyladenylate synthase
LDL57_07760	COG1028	Short-chain dehydrogenase reductase Sdr
LDL57_07765	COG0616	signal peptide processing
LDL57_07780	COG0583	DNA-binding transcription factor activity
LDL57_07790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDL57_07795	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
LDL57_07800	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LDL57_07805	COG0284	orotidine-5'-phosphate decarboxylase activity
LDL57_07820	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LDL57_07825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LDL57_07835	COG4659	FMN binding
LDL57_07845	COG4656	Part of a membrane complex involved in electron transport
LDL57_07855	COG4657	Part of a membrane complex involved in electron transport
LDL57_07860	COG0673	inositol 2-dehydrogenase activity
LDL57_07875	COG5339	Protein conserved in bacteria
LDL57_07885	COG0114	fumarate hydratase activity
LDL57_07900	COG2814	Major facilitator Superfamily
LDL57_07910	COG1940	carbohydrate kinase activity
LDL57_07915	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LDL57_07960	COG2249	NAD(P)H dehydrogenase (quinone) activity
LDL57_07965	COG0583	DNA-binding transcription factor activity
LDL57_07970	COG0656	L-ascorbic acid biosynthetic process
LDL57_08005	COG3634	alkyl hydroperoxide reductase activity
LDL57_08010	COG0450	alkyl hydroperoxide reductase
LDL57_08020	COG0604	alcohol dehydrogenase
LDL57_08020	COG1028	Short-chain dehydrogenase reductase Sdr
LDL57_08020	COG3321	synthase
LDL57_08035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LDL57_08040	COG0589	response to stress
LDL57_08050	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LDL57_08060	COG0531	amino acid
LDL57_08090	COG1643	Atp-dependent helicase
LDL57_08095	COG3784	Protein of unknown function (DUF1318)
LDL57_08105	COG2911	Protein conserved in bacteria
LDL57_08110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LDL57_08120	COG2983	Belongs to the UPF0260 family
LDL57_08125	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDL57_08130	COG2951	lytic endotransglycosylase activity
LDL57_08135	COG3100	YcgL domain-containing protein
LDL57_08140	COG0850	regulation of cytokinetic process
LDL57_08145	COG2894	cell division
LDL57_08150	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LDL57_08165	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LDL57_08170	COG0318	PFAM AMP-dependent synthetase and ligase
LDL57_08175	COG3065	identical protein binding
LDL57_08185	COG1199	ATP-dependent helicase activity
LDL57_08190	COG0251	oxidation-reduction process
LDL57_08210	COG3397	chitin binding
LDL57_08230	COG2076	Multidrug Resistance protein
LDL57_08235	COG2076	Multidrug Resistance protein
LDL57_08240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LDL57_08245	COG1737	Transcriptional regulator
LDL57_08250	COG0469	pyruvate kinase activity
LDL57_08255	COG1560	Kdo2-lipid A biosynthetic process
LDL57_08260	COG0739	heme binding
LDL57_08265	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LDL57_08270	COG1121	(ABC) transporter
LDL57_08275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LDL57_08290	COG3617	BRO family, N-terminal domain
LDL57_08305	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LDL57_08480	COG5484	DNA packaging
LDL57_08480	COG3728	DNA packaging
LDL57_08500	COG3772	lysozyme
LDL57_08685	COG0582	viral genome integration into host DNA
LDL57_08695	COG2255	four-way junction helicase activity
LDL57_08700	COG0632	four-way junction helicase activity
LDL57_08705	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LDL57_08710	COG0217	transcriptional regulatory protein
LDL57_08715	COG0494	nUDIX hydrolase
LDL57_08720	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LDL57_08725	COG3788	relative of glutathione S-transferase, MAPEG superfamily
LDL57_08730	COG2226	methyltransferase
LDL57_08735	COG0500	methyltransferase
LDL57_08740	COG3142	Participates in the control of copper homeostasis
LDL57_08745	COG0018	arginyl-trna synthetase
LDL57_08750	COG1609	Transcriptional regulator
LDL57_08760	COG2814	Major facilitator Superfamily
LDL57_08765	COG0307	riboflavin synthase, alpha
LDL57_08770	COG0534	Mate efflux family protein
LDL57_08790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LDL57_08795	COG0477	Major facilitator Superfamily
LDL57_08805	COG3381	protein complex oligomerization
LDL57_08815	COG1242	4 iron, 4 sulfur cluster binding
LDL57_08825	COG2912	Transglutaminase-like superfamily
LDL57_08830	COG2890	protein-(glutamine-N5) methyltransferase activity
LDL57_08835	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LDL57_08840	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LDL57_08845	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LDL57_08850	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LDL57_08855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LDL57_08865	COG0193	aminoacyl-tRNA hydrolase activity
LDL57_08870	COG0012	GTP binding
LDL57_08875	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LDL57_08885	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LDL57_08925	COG1702	phosphate starvation-inducible protein PhoH
LDL57_08945	COG3610	response to peptide
LDL57_08950	COG2966	Psort location CytoplasmicMembrane, score
LDL57_08970	COG0501	Belongs to the peptidase M48B family
LDL57_08980	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LDL57_08985	COG1956	GAF domain-containing protein
LDL57_09000	COG1528	Iron-storage protein
LDL57_09015	COG3140	Belongs to the UPF0181 family
LDL57_09020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LDL57_09025	COG0494	nUDIX hydrolase
LDL57_09030	COG1760	l-serine dehydratase
LDL57_09035	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDL57_09035	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LDL57_09040	COG3715	PTS system
LDL57_09045	COG3716	PTS system mannose fructose sorbose family IID component
LDL57_09050	COG4811	Protein of unknown function (DUF986)
LDL57_09055	COG1971	Probably functions as a manganese efflux pump
LDL57_09060	COG2207	Transcriptional regulator
LDL57_09065	COG0095	Lipoate-protein ligase
LDL57_09070	COG0791	NLP P60 protein
LDL57_09075	COG2076	Multidrug Resistance protein
LDL57_09080	COG2076	Multidrug Resistance protein
LDL57_09085	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LDL57_09090	COG0726	polysaccharide deacetylase
LDL57_09095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDL57_09095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LDL57_09100	COG0463	Glycosyl transferase, family 2
LDL57_09105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LDL57_09110	COG0776	regulation of translation
LDL57_09115	COG0072	phenylalanine-tRNA ligase activity
LDL57_09115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDL57_09120	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LDL57_09130	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LDL57_09135	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LDL57_09140	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LDL57_09145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LDL57_09155	COG0803	Belongs to the bacterial solute-binding protein 9 family
LDL57_09160	COG1121	(ABC) transporter
LDL57_09165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LDL57_09170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LDL57_09180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDL57_09185	COG1988	membrane-bound metal-dependent
LDL57_09190	COG1823	symporter activity
LDL57_09220	COG1605	Chorismate mutase
LDL57_09240	COG3381	protein complex oligomerization
LDL57_09245	COG3302	dmso reductase anchor subunit
LDL57_09250	COG0437	4 iron, 4 sulfur cluster binding
LDL57_09255	COG0243	molybdopterin cofactor binding
LDL57_09280	COG0471	metal ion transport
LDL57_09285	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LDL57_09295	COG2982	Protein involved in outer membrane biogenesis
LDL57_09300	COG0717	Belongs to the dCTP deaminase family
LDL57_09305	COG0572	uridine kinase
LDL57_09310	COG0489	protein tyrosine kinase activity
LDL57_09315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDL57_09315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDL57_09320	COG1380	Effector of murein hydrolase LrgA
LDL57_09325	COG1346	cytolysis
LDL57_09330	COG2949	membrane
LDL57_09345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDL57_09365	COG0303	'Molybdopterin
LDL57_09370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LDL57_09380	COG5006	permease, DMT superfamily
LDL57_09385	COG0783	Belongs to the Dps family
LDL57_09390	COG2824	Alkylphosphonate utilization operon protein PhnA
LDL57_09400	COG2897	thiosulfate sulfurtransferase activity
LDL57_09405	COG2261	transglycosylase associated protein
LDL57_09410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LDL57_09415	COG0513	Belongs to the DEAD box helicase family
LDL57_09425	COG1131	(ABC) transporter
LDL57_09430	COG0842	Transport permease protein
LDL57_09435	COG0842	Transport permease protein
LDL57_09445	COG0314	molybdopterin synthase activity
LDL57_09450	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LDL57_09460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LDL57_09465	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LDL57_09470	COG0556	nucleotide-excision repair
LDL57_09485	COG0156	8-amino-7-oxononanoate synthase activity
LDL57_09490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LDL57_09500	COG2706	6-phosphogluconolactonase activity
LDL57_09515	COG0561	phosphatase activity
LDL57_09520	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LDL57_09525	COG4149	molybdate abc transporter
LDL57_09530	COG0725	ABC transporter, periplasmic molybdate-binding protein
LDL57_09535	COG1113	amino acid transport
LDL57_09540	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LDL57_09555	COG1191	sigma factor activity
LDL57_09590	COG1677	Flagellar hook-basal body complex protein FliE
LDL57_09600	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LDL57_09615	COG1157	protein secretion by the type III secretion system
LDL57_09620	COG2882	bacterial-type flagellum organization
LDL57_09625	COG3144	bacterial-type flagellum assembly
LDL57_09630	COG1580	Controls the rotational direction of flagella during chemotaxis
LDL57_09650	COG1338	Plays a role in the flagellum-specific transport system
LDL57_09655	COG1987	bacterial-type flagellum assembly
LDL57_09670	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LDL57_09675	COG1256	bacterial-type flagellum assembly
LDL57_09685	COG1706	bacterial-type flagellum-dependent cell motility
LDL57_09690	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LDL57_09700	COG4787	bacterial-type flagellum-dependent cell motility
LDL57_09715	COG1558	bacterial-type flagellum-dependent cell motility
LDL57_09720	COG1815	bacterial-type flagellum-dependent cell motility
LDL57_09780	COG0745	RESPONSE REGULATOR receiver
LDL57_09785	COG2201	protein-glutamate methylesterase activity
LDL57_09795	COG0840	transmembrane signaling receptor activity
LDL57_09815	COG0643	Histidine kinase
LDL57_09815	COG2198	Histidine kinase
LDL57_09870	COG0418	dihydroorotase activity
LDL57_09880	COG1560	Kdo2-lipid A biosynthetic process
LDL57_09890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDL57_09920	COG0438	transferase activity, transferring glycosyl groups
LDL57_09930	COG0726	polysaccharide deacetylase
LDL57_09990	COG2920	part of a sulfur-relay system
LDL57_09995	COG1254	Belongs to the acylphosphatase family
LDL57_10000	COG3785	DNA binding
LDL57_10005	COG1832	CoA-binding protein
LDL57_10010	COG1803	Methylglyoxal synthase
LDL57_10015	COG0210	DNA helicase
LDL57_10020	COG1289	transmembrane transporter activity
LDL57_10025	COG3070	regulator of competence-specific genes
LDL57_10040	COG3120	sequence-specific DNA binding
LDL57_10045	COG1067	ATP-dependent peptidase activity
LDL57_10050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LDL57_10055	COG3009	Protein conserved in bacteria
LDL57_10060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LDL57_10060	COG3008	intermembrane lipid transfer
LDL57_10065	COG2995	paraquat-inducible protein a
LDL57_10070	COG0488	(ABC) transporter
LDL57_10075	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LDL57_10075	COG0116	Belongs to the methyltransferase superfamily
LDL57_10080	COG3217	Mosc domain protein beta barrel domain protein
LDL57_10080	COG0633	Ferredoxin
LDL57_10090	COG0167	dihydroorotate dehydrogenase activity
LDL57_10100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LDL57_10105	COG0017	Asparaginyl-tRNA synthetase
LDL57_10110	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LDL57_10115	COG1448	Aminotransferase
LDL57_10120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDL57_10125	COG3108	Peptidase M15
LDL57_10130	COG2989	Protein conserved in bacteria
LDL57_10140	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LDL57_10145	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
LDL57_10150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LDL57_10155	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LDL57_10160	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LDL57_10165	COG2835	tetraacyldisaccharide 4'-kinase activity
LDL57_10170	COG1278	Cold shock
LDL57_10175	COG1663	tetraacyldisaccharide 4'-kinase activity
LDL57_10180	COG1132	(ABC) transporter
LDL57_10190	COG0776	regulation of translation
LDL57_10195	COG0539	negative regulation of cytoplasmic translation
LDL57_10200	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LDL57_10205	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LDL57_10210	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LDL57_10215	COG0252	asparaginase activity
LDL57_10220	COG1944	ATP diphosphatase activity
LDL57_10225	COG2116	formate transmembrane transporter activity
LDL57_10230	COG1882	Formate acetyltransferase
LDL57_10235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LDL57_10290	COG2161	toxin-antitoxin pair type II binding
LDL57_10295	COG4115	mRNA cleavage
LDL57_10300	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LDL57_10305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LDL57_10310	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LDL57_10315	COG1674	ftsk spoiiie
LDL57_10315	COG3107	peptidoglycan biosynthetic process
LDL57_10325	COG0492	ferredoxin-NADP+ reductase activity
LDL57_10335	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LDL57_10340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LDL57_10345	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LDL57_10350	COG0542	response to heat
LDL57_10355	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LDL57_10360	COG1278	Cold shock
LDL57_10370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDL57_10375	COG3593	DNA synthesis involved in DNA repair
LDL57_10380	COG2431	L-lysine efflux transmembrane transporter activity
LDL57_10390	COG1126	abc transporter atp-binding protein
LDL57_10395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDL57_10400	COG4215	(ABC) transporter
LDL57_10405	COG4160	amino acid transport
LDL57_10430	COG0432	Pfam Uncharacterised protein family UPF0047
LDL57_10435	COG0671	phosphoesterase, PA-phosphatase related
LDL57_10440	COG0814	amino acid
LDL57_10445	COG1760	l-serine dehydratase
LDL57_10455	COG1686	Belongs to the peptidase S11 family
LDL57_10460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDL57_10465	COG1454	alcohol dehydrogenase
LDL57_10485	COG2005	Transcriptional regulator
LDL57_10485	COG3585	molybdate ion transport
LDL57_10510	COG0588	phosphoglycerate mutase activity
LDL57_10515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LDL57_10550	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LDL57_10555	COG2885	chlorophyll binding
LDL57_10560	COG0823	Involved in the tonB-independent uptake of proteins
LDL57_10565	COG3064	Membrane
LDL57_10565	COG3064	Membrane
LDL57_10570	COG0848	biopolymer transport protein
LDL57_10575	COG0811	peptide transport
LDL57_10580	COG0824	Thioesterase
LDL57_10590	COG4890	Cyd operon protein YbgT
LDL57_10595	COG1294	oxidase, subunit
LDL57_10600	COG1271	oxidase subunit
LDL57_10610	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LDL57_10615	COG0045	succinate-CoA ligase (ADP-forming) activity
LDL57_10625	COG0567	Dehydrogenase, E1 component
LDL57_10635	COG1053	succinate dehydrogenase
LDL57_10640	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LDL57_10645	COG2009	succinate dehydrogenase
LDL57_10655	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LDL57_10675	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LDL57_10685	COG2205	protein histidine kinase activity
LDL57_10690	COG0745	RESPONSE REGULATOR receiver
LDL57_10695	COG0033	Phosphoglucomutase
LDL57_10700	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LDL57_10705	COG0596	Alpha beta hydrolase
LDL57_10735	COG0735	belongs to the Fur family
LDL57_10750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDL57_10755	COG1263	PTS System
LDL57_10755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LDL57_10755	COG2190	(PTS) system
LDL57_10760	COG0363	glucosamine-6-phosphate deaminase activity
LDL57_10765	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LDL57_10805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDL57_10810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LDL57_10815	COG1702	phosphate starvation-inducible protein PhoH
LDL57_10820	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LDL57_10825	COG4535	Mg2 and Co2 transporter CorC
LDL57_10830	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LDL57_10835	COG1126	abc transporter atp-binding protein
LDL57_10840	COG0495	leucyl-tRNA aminoacylation
LDL57_10845	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
LDL57_10850	COG1466	dna polymerase III delta subunit
LDL57_10860	COG0799	negative regulation of ribosome biogenesis
LDL57_10865	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LDL57_10870	COG0768	penicillin binding
LDL57_10875	COG0772	Belongs to the SEDS family
LDL57_10880	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LDL57_10885	COG1686	Belongs to the peptidase S11 family
LDL57_10890	COG2921	Belongs to the UPF0250 family
LDL57_10895	COG0321	lipoyl(octanoyl) transferase activity
LDL57_10900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LDL57_10905	COG1278	Cold shock
LDL57_10910	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LDL57_10920	COG1780	Probably involved in ribonucleotide reductase function
LDL57_10935	COG4175	Glycine betaine
LDL57_10940	COG4176	ABC-type proline glycine betaine transport system permease component
LDL57_10945	COG2113	Glycine betaine
LDL57_10950	COG1846	Transcriptional regulator
LDL57_10955	COG1566	PFAM secretion protein HlyD family protein
LDL57_10960	COG2814	Major facilitator Superfamily
LDL57_10965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDL57_10990	COG0045	succinate-CoA ligase (ADP-forming) activity
LDL57_10990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LDL57_10990	COG1042	CoA-binding domain protein
LDL57_10995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LDL57_11020	COG0542	response to heat
LDL57_11025	COG1496	oxidoreductase activity
LDL57_11030	COG0564	pseudouridine synthase activity
LDL57_11035	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LDL57_11040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LDL57_11050	COG0287	Prephenate dehydrogenase
LDL57_11050	COG1605	Chorismate mutase
LDL57_11075	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LDL57_11085	COG3260	NADH ubiquinone oxidoreductase 20
LDL57_11090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDL57_11095	COG3261	NADH dehydrogenase
LDL57_11095	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LDL57_11100	COG0650	Formate hydrogenlyase subunit 4
LDL57_11105	COG0651	ATP synthesis coupled electron transport
LDL57_11110	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LDL57_11125	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LDL57_11130	COG0298	carbon dioxide binding
LDL57_11135	COG0409	Hydrogenase expression formation protein
LDL57_11140	COG0309	Hydrogenase expression formation protein (HypE)
LDL57_11145	COG3604	Transcriptional regulator
LDL57_11175	COG4935	Belongs to the peptidase S8 family
LDL57_11175	COG1404	Belongs to the peptidase S8 family
LDL57_11180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LDL57_11200	COG2841	Protein conserved in bacteria
LDL57_11215	COG2221	Nitrite and sulphite reductase 4Fe-4S
LDL57_11215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LDL57_11305	COG4790	Type iii secretion
LDL57_11310	COG4794	Type iii secretion
LDL57_11315	COG4791	protein targeting
LDL57_11395	COG3137	Salt-induced outer membrane protein
LDL57_11400	COG4221	oxidoreductase activity
LDL57_11405	COG1349	DNA-binding transcription factor activity
LDL57_11415	COG2222	sugar isomerase
LDL57_11420	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LDL57_11425	COG3715	PTS system
LDL57_11430	COG3716	PTS system mannose fructose sorbose family IID component
LDL57_11465	COG3064	Membrane
LDL57_11465	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
LDL57_11465	COG1073	alpha beta
LDL57_11485	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LDL57_11490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LDL57_11500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LDL57_11505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LDL57_11510	COG4974	Belongs to the 'phage' integrase family
LDL57_11525	COG0716	FMN binding
LDL57_11535	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LDL57_11540	COG0354	folic acid binding
LDL57_11560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LDL57_11565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDL57_11570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDL57_11575	COG0006	proline dipeptidase activity
LDL57_11580	COG3079	Belongs to the UPF0149 family
LDL57_11585	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LDL57_11595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LDL57_11605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDL57_11610	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LDL57_11615	COG0583	DNA-binding transcription factor activity
LDL57_11640	COG0668	transmembrane transport
LDL57_11645	COG3112	Uncharacterised protein family (UPF0231)
LDL57_11660	COG3646	Phage regulatory protein
LDL57_11800	COG3772	lysozyme
LDL57_11960	COG3561	AntA/AntB antirepressor
LDL57_11990	COG3561	AntA/AntB antirepressor
LDL57_12000	COG0582	viral genome integration into host DNA
LDL57_12010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDL57_12015	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDL57_12020	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LDL57_12040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LDL57_12045	COG1459	type II secretion system
LDL57_12055	COG0237	dephospho-CoA kinase activity
LDL57_12060	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LDL57_12065	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LDL57_12070	COG0494	nUDIX hydrolase
LDL57_12075	COG0653	protein targeting
LDL57_12090	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LDL57_12095	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LDL57_12100	COG0849	cell division
LDL57_12105	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LDL57_12110	COG1181	Belongs to the D-alanine--D-alanine ligase family
LDL57_12115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LDL57_12120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LDL57_12125	COG0772	Belongs to the SEDS family
LDL57_12135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LDL57_12140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LDL57_12145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LDL57_12150	COG0768	penicillin binding
LDL57_12155	COG3116	cell division
LDL57_12160	COG0275	rRNA processing
LDL57_12165	COG2001	Belongs to the MraZ family
LDL57_12170	COG1609	Transcriptional regulator
LDL57_12175	COG1022	Amp-dependent synthetase and ligase
LDL57_12180	COG0583	DNA-binding transcription factor activity
LDL57_12190	COG0473	3-isopropylmalate dehydrogenase activity
LDL57_12195	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LDL57_12200	COG0066	3-isopropylmalate dehydratase activity
LDL57_12205	COG3066	DNA modification
LDL57_12230	COG0010	Belongs to the arginase family
LDL57_12235	COG1166	arginine decarboxylase activity
LDL57_12240	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LDL57_12245	COG3091	SprT-like family
LDL57_12250	COG2239	Acts as a magnesium transporter
LDL57_12260	COG2353	YceI-like domain
LDL57_12265	COG3038	cytochrome b561
LDL57_12285	COG3023	N-Acetylmuramoyl-L-alanine amidase
LDL57_12355	COG4771	TonB-dependent receptor
LDL57_12360	COG0747	negative chemotaxis
LDL57_12365	COG0601	transmembrane transport
LDL57_12370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDL57_12385	COG2323	membrane
LDL57_12450	COG2501	S4 domain
LDL57_12465	COG0215	cysteine-tRNA ligase activity
LDL57_12470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LDL57_12475	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LDL57_12480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LDL57_12485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LDL57_12500	COG3118	belongs to the thioredoxin family
LDL57_12505	COG0330	HflC and HflK could
LDL57_12510	COG1585	Membrane protein implicated in regulation of membrane protease activity
LDL57_12520	COG2217	Heavy metal translocating P-type atpase
LDL57_12525	COG3735	TraB family
LDL57_12530	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LDL57_12540	COG4651	solute:proton antiporter activity
LDL57_12540	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LDL57_12545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDL57_12550	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
LDL57_12555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LDL57_12560	COG0563	adenylate kinase activity
LDL57_12565	COG0326	Molecular chaperone. Has ATPase activity
LDL57_12570	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LDL57_12575	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LDL57_12585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LDL57_12600	COG3264	Mechanosensitive ion channel
LDL57_12600	COG1196	nuclear chromosome segregation
LDL57_12605	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LDL57_12610	COG1309	transcriptional regulator
LDL57_12615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDL57_12620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LDL57_12640	COG1132	(ABC) transporter
LDL57_12645	COG1132	(ABC) transporter
LDL57_12650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LDL57_12660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LDL57_12665	COG0776	regulation of translation
LDL57_12670	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LDL57_12675	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LDL57_12680	COG0740	serine-type endopeptidase activity
LDL57_12690	COG0271	Belongs to the BolA IbaG family
LDL57_12695	COG3056	Lipoprotein
LDL57_12710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LDL57_12715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LDL57_12720	COG1845	cytochrome c oxidase, subunit III
LDL57_12725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LDL57_12730	COG0109	protoheme IX farnesyltransferase activity
LDL57_12735	COG2814	Major facilitator Superfamily
LDL57_12740	COG1666	GTP binding
LDL57_12745	COG0693	protein deglycase activity
LDL57_12750	COG0301	tRNA thio-modification
LDL57_12750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LDL57_12760	COG0142	geranyltranstransferase activity
LDL57_12765	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LDL57_12770	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LDL57_12775	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LDL57_12780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LDL57_12785	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LDL57_12790	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LDL57_12790	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LDL57_12795	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LDL57_12800	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDL57_12810	COG1862	Preprotein translocase
LDL57_12815	COG0343	queuine tRNA-ribosyltransferase activity
LDL57_12820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LDL57_12825	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
LDL57_12830	COG1114	Component of the transport system for branched-chain amino acids
LDL57_12835	COG5002	protein histidine kinase activity
LDL57_12840	COG0745	RESPONSE REGULATOR receiver
LDL57_12855	COG2974	May be involved in recombination
LDL57_12860	COG0848	biopolymer transport protein
LDL57_12875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LDL57_12885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LDL57_12890	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LDL57_12895	COG1047	Peptidyl-prolyl cis-trans
LDL57_12900	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LDL57_12905	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LDL57_12910	COG0196	riboflavin kinase activity
LDL57_12915	COG0268	Binds directly to 16S ribosomal RNA
LDL57_12920	COG0583	DNA-binding transcription factor activity
LDL57_12925	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LDL57_12940	COG0484	heat shock protein binding
LDL57_12945	COG0443	Heat shock 70 kDa protein
LDL57_12950	COG1584	GPR1 FUN34 yaaH family protein
LDL57_12970	COG0521	Mo-molybdopterin cofactor biosynthetic process
LDL57_12975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LDL57_12980	COG3022	response to hydroperoxide
LDL57_12990	COG0083	homoserine kinase activity
LDL57_13005	COG0745	RESPONSE REGULATOR receiver
LDL57_13010	COG3045	CreA protein
LDL57_13015	COG2207	Transcriptional regulator
LDL57_13015	COG3708	Transcriptional regulator
LDL57_13030	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
LDL57_13040	COG0488	(ABC) transporter
LDL57_13050	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LDL57_13055	COG0560	Phosphoserine phosphatase
LDL57_13060	COG3726	membrane protein affecting hemolysin expression
LDL57_13065	COG0813	purine-nucleoside phosphorylase activity
LDL57_13070	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LDL57_13080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LDL57_13085	COG0084	hydrolase, TatD family'
LDL57_13090	COG4667	esterase of the alpha-beta hydrolase superfamily
LDL57_13095	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LDL57_13110	COG0456	acetyltransferase
LDL57_13120	COG2813	Specifically methylates the guanine in position
LDL57_13130	COG1216	Glycosyl transferase, family 2
LDL57_13165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LDL57_13170	COG1739	Uncharacterized protein family UPF0029
LDL57_13180	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDL57_13180	COG1024	Enoyl-CoA hydratase
LDL57_13185	COG0183	Belongs to the thiolase family
LDL57_13195	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LDL57_13210	COG0805	protein transport
LDL57_13215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LDL57_13220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LDL57_13230	COG3165	ubiquinone biosynthetic process from chorismate
LDL57_13235	COG2226	methyltransferase
LDL57_13240	COG1322	Protein conserved in bacteria
LDL57_13245	COG0586	Pfam SNARE associated Golgi protein
LDL57_13250	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
LDL57_13265	COG0025	NhaP-type Na H and K H
LDL57_13270	COG2252	PERMEase
LDL57_13290	COG1278	Cold shock
LDL57_13305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LDL57_13310	COG3479	Phenolic acid decarboxylase
LDL57_13355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LDL57_13450	COG0425	Belongs to the sulfur carrier protein TusA family
LDL57_13455	COG2391	methyltransferase activity
LDL57_13460	COG0583	DNA-binding transcription factor activity
LDL57_13470	COG0071	Belongs to the small heat shock protein (HSP20) family
LDL57_13490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LDL57_13505	COG0459	protein refolding
LDL57_13510	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LDL57_13515	COG3030	protein affecting phage T7 exclusion by the F plasmid
LDL57_13525	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LDL57_13530	COG4232	protein-disulfide reductase activity
LDL57_13535	COG1309	transcriptional regulator
LDL57_13565	COG1472	Belongs to the glycosyl hydrolase 3 family
LDL57_13575	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LDL57_13580	COG0076	glutamate decarboxylase activity
LDL57_13585	COG4114	ferric iron reductase
LDL57_13590	COG1120	ATPase activity
LDL57_13600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDL57_13605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LDL57_13610	COG4773	Receptor
LDL57_13620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDL57_13625	COG1554	hydrolase, family 65, central catalytic
LDL57_13630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LDL57_13630	COG1263	PTS System
LDL57_13650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LDL57_13675	COG0583	DNA-binding transcription factor activity
LDL57_13680	COG1902	pentaerythritol trinitrate reductase activity
LDL57_13680	COG0446	pyridine nucleotide-disulphide oxidoreductase
LDL57_13685	COG0861	Integral membrane protein TerC family
LDL57_13690	COG0586	Pfam SNARE associated Golgi protein
LDL57_13695	COG4575	ribosome binding
LDL57_13700	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
LDL57_13710	COG2259	Doxx family
LDL57_13715	COG0583	DNA-binding transcription factor activity
LDL57_13720	COG1741	Belongs to the pirin family
LDL57_13760	COG3964	amidohydrolase
LDL57_13780	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LDL57_13790	COG0792	nuclease activity
LDL57_13795	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LDL57_13800	COG2823	Periplasmic or secreted lipoprotein
LDL57_13805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDL57_13810	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LDL57_13815	COG5002	protein histidine kinase activity
LDL57_13815	COG0784	Response regulator, receiver
LDL57_13815	COG2198	Histidine kinase
LDL57_13820	COG2969	positive regulation of protein catabolic process
LDL57_13825	COG0625	glutathione transferase activity
LDL57_13835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LDL57_13840	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LDL57_13845	COG3105	Protein conserved in bacteria
LDL57_13850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDL57_13855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDL57_13860	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LDL57_13865	COG5007	Belongs to the BolA IbaG family
LDL57_13875	COG2854	intermembrane phospholipid transfer
LDL57_13880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LDL57_13885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LDL57_13890	COG1127	ABC transporter
LDL57_13895	COG0517	IMP dehydrogenase activity
LDL57_13895	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LDL57_13900	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LDL57_13905	COG3117	lipopolysaccharide transmembrane transporter activity
LDL57_13910	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LDL57_13915	COG1137	ATPase activity
LDL57_13920	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LDL57_13925	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LDL57_13940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDL57_13945	COG0312	modulator of DNA gyrase
LDL57_13950	COG3028	Belongs to the UPF0307 family
LDL57_13955	COG2732	(Barnase) inhibitor
LDL57_13960	COG4290	ribonuclease
LDL57_13965	COG0312	modulator of DNA gyrase
LDL57_13970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LDL57_13975	COG3164	Protein of unknown function
LDL57_13985	COG0424	maF-like protein
LDL57_13990	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LDL57_13995	COG1792	Involved in formation and maintenance of cell shape
LDL57_14000	COG1077	Cell shape determining protein MreB Mrl
LDL57_14010	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LDL57_14015	COG0511	ligase activity, forming carbon-carbon bonds
LDL57_14020	COG0439	Biotin carboxylase
LDL57_14025	COG3924	membrane
LDL57_14030	COG4145	pantothenate transmembrane transporter activity
LDL57_14035	COG2264	protein methyltransferase activity
LDL57_14040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LDL57_14045	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LDL57_14075	COG2177	Part of the ABC transporter FtsEX involved in
LDL57_14080	COG2884	Cell division ATP-binding protein ftsE
LDL57_14085	COG0552	protein localization to endoplasmic reticulum
LDL57_14090	COG0742	ribosomal rna small subunit methyltransferase
LDL57_14095	COG3776	membrane
LDL57_14115	COG0425	Belongs to the sulfur carrier protein TusA family
LDL57_14120	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LDL57_14125	COG2271	Major facilitator Superfamily
LDL57_14130	COG0584	glycerophosphoryl diester phosphodiesterase
LDL57_14140	COG1053	succinate dehydrogenase
LDL57_14145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LDL57_14150	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LDL57_14155	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LDL57_14170	COG3683	transport system, periplasmic component
LDL57_14175	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LDL57_14185	COG3069	C4-dicarboxylate transmembrane transporter activity
LDL57_14190	COG0579	oxidoreductase
LDL57_14205	COG3188	usher protein
LDL57_14265	COG2992	FlgJ-related protein
LDL57_14270	COG2610	gluconate transmembrane transporter activity
LDL57_14275	COG3265	gluconokinase activity
LDL57_14280	COG0735	belongs to the Fur family
LDL57_14290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LDL57_14295	COG2937	Belongs to the GPAT DAPAT family
LDL57_14300	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LDL57_14310	COG0166	Belongs to the GPI family
LDL57_14315	COG0527	aspartate kinase activity
LDL57_14335	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LDL57_14345	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LDL57_14375	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LDL57_14380	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDL57_14385	COG0009	L-threonylcarbamoyladenylate synthase
LDL57_14390	COG0551	DNA topoisomerase type I activity
LDL57_14395	COG0758	DNA mediated transformation
LDL57_14400	COG0242	peptide deformylase activity
LDL57_14405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LDL57_14410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LDL57_14410	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LDL57_14420	COG1970	mechanosensitive ion channel activity
LDL57_14425	COG3036	rescue of stalled ribosome
LDL57_14430	COG0789	Transcriptional regulator
LDL57_14435	COG0203	ribosomal protein L17
LDL57_14445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LDL57_14455	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LDL57_14460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LDL57_14465	COG0201	protein transport
LDL57_14470	COG0200	Binds to the 23S rRNA
LDL57_14475	COG1841	ribosomal large subunit assembly
LDL57_14480	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LDL57_14485	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LDL57_14490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LDL57_14495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LDL57_14500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LDL57_14505	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LDL57_14515	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LDL57_14520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LDL57_14530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LDL57_14550	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LDL57_14555	COG0089	rRNA binding
LDL57_14560	COG0088	Forms part of the polypeptide exit tunnel
LDL57_14565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LDL57_14570	COG0051	transcription antitermination factor activity, RNA binding
LDL57_14585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LDL57_14610	COG1072	(Pantothenic acid kinase))
LDL57_14620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LDL57_14645	COG0138	bifunctional purine biosynthesis protein purh
LDL57_14650	COG0151	Belongs to the GarS family
LDL57_14665	COG3068	Protein conserved in bacteria
LDL57_14670	COG1515	deoxyribonuclease V activity
LDL57_14680	COG2816	NAD+ diphosphatase activity
LDL57_14690	COG0352	thiamine-phosphate diphosphorylase activity
LDL57_14700	COG2104	thiamine diphosphate biosynthetic process
LDL57_14705	COG2022	thiamine diphosphate biosynthetic process
LDL57_14710	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LDL57_14715	COG0726	polysaccharide deacetylase
LDL57_14725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LDL57_14730	COG0085	RNA polymerase activity
LDL57_14735	COG0222	ribosome binding
LDL57_14740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LDL57_14750	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LDL57_14755	COG0250	Participates in transcription elongation, termination and antitermination
LDL57_14765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LDL57_14770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LDL57_14775	COG0049	tRNA binding
LDL57_14780	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LDL57_14785	COG2168	tRNA wobble position uridine thiolation
LDL57_14790	COG2923	Belongs to the DsrF TusC family
LDL57_14795	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LDL57_14800	COG2964	Protein conserved in bacteria
LDL57_14805	COG0545	Peptidyl-prolyl cis-trans isomerase
LDL57_14810	COG2900	Belongs to the SlyX family
LDL57_14815	COG1047	Peptidyl-prolyl cis-trans
LDL57_14830	COG2249	NAD(P)H dehydrogenase (quinone) activity
LDL57_14835	COG0488	(ABC) transporter
LDL57_14845	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LDL57_14860	COG0429	hydrolase of the alpha beta-hydrolase fold
LDL57_14870	COG3954	Phosphoribulokinase
LDL57_14875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LDL57_14880	COG3189	MarR family transcriptional regulator
LDL57_14900	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LDL57_14910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LDL57_14915	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LDL57_14920	COG3084	Protein conserved in bacteria
LDL57_14955	COG0746	molybdenum cofactor guanylyltransferase activity
LDL57_14960	COG1763	Mo-molybdopterin cofactor biosynthetic process
LDL57_14970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDL57_14975	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LDL57_14985	COG1295	ribonuclease BN
LDL57_14990	COG0612	Peptidase, M16
LDL57_15005	COG4608	Belongs to the ABC transporter superfamily
LDL57_15010	COG0444	Belongs to the ABC transporter superfamily
LDL57_15015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDL57_15020	COG0601	transmembrane transport
LDL57_15025	COG0747	negative chemotaxis
LDL57_15030	COG2831	hemolysin activation secretion protein
LDL57_15050	COG0751	glycine-tRNA ligase activity
LDL57_15075	COG5539	protein K27-linked deubiquitination
LDL57_15075	COG3774	pathogenesis
LDL57_15085	COG2818	Glycosylase
LDL57_15090	COG3977	Valine--pyruvate aminotransferase
LDL57_15095	COG5645	(Lipo)protein
LDL57_15110	COG0823	Involved in the tonB-independent uptake of proteins
LDL57_15115	COG2860	membrane
LDL57_15125	COG0194	GDP metabolic process
LDL57_15135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LDL57_15140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDL57_15145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LDL57_15150	COG0786	glutamate:sodium symporter activity
LDL57_15155	COG2982	Protein involved in outer membrane biogenesis
LDL57_15165	COG1490	D-aminoacyl-tRNA deacylase activity
LDL57_15170	COG1011	Hydrolase
LDL57_15185	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LDL57_15190	COG0460	homoserine dehydrogenase
LDL57_15190	COG0527	aspartate kinase activity
LDL57_15195	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
LDL57_15205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LDL57_15210	COG1609	Transcriptional regulator
LDL57_15215	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LDL57_15220	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LDL57_15225	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LDL57_15230	COG1575	Belongs to the MenA family. Type 1 subfamily
LDL57_15235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LDL57_15240	COG3074	FtsZ-dependent cytokinesis
LDL57_15265	COG2814	Major facilitator Superfamily
LDL57_15285	COG0149	triose-phosphate isomerase activity
LDL57_15300	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LDL57_15305	COG3121	Chaperone
LDL57_15315	COG3188	usher protein
LDL57_15320	COG3121	Chaperone
LDL57_15330	COG0800	Aldolase
LDL57_15425	COG3276	selenocysteine insertion sequence binding
LDL57_15430	COG1921	L-seryl-tRNASec selenium transferase activity
LDL57_15435	COG3058	Necessary for formate dehydrogenase activity
LDL57_15440	COG2864	formate dehydrogenase
LDL57_15455	COG0437	4 iron, 4 sulfur cluster binding
LDL57_15465	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LDL57_15495	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LDL57_15500	COG0454	-acetyltransferase
LDL57_15525	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LDL57_15525	COG0493	'glutamate synthase
LDL57_15530	COG2233	PERMEase
LDL57_15545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LDL57_15550	COG0706	membrane insertase activity
LDL57_15555	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LDL57_15560	COG0594	ribonuclease P activity
LDL57_15565	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LDL57_15765	COG0741	lytic transglycosylase activity
LDL57_15805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LDL57_15880	COG0776	regulation of translation
LDL57_16065	COG1278	Cold shock
LDL57_16070	COG3223	Belongs to the PsiE family
LDL57_16075	COG0071	Belongs to the small heat shock protein (HSP20) family
LDL57_16120	COG0776	regulation of translation
LDL57_16215	COG0776	regulation of translation
LDL57_16230	COG1192	Involved in chromosome partitioning
LDL57_16285	COG4104	PAAR repeat-containing protein
LDL57_16325	COG1304	FMN binding
LDL57_16425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LDL57_16430	COG0322	excinuclease ABC activity
LDL57_16460	COG0776	regulation of translation
LDL57_16490	COG5002	protein histidine kinase activity
LDL57_16490	COG0784	Response regulator, receiver
LDL57_16685	COG3772	lysozyme
LDL57_16700	COG3728	DNA packaging
LDL57_16700	COG5484	DNA packaging
LDL57_16845	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LDL57_16865	COG3617	BRO family, N-terminal domain
LDL57_16870	COG0582	viral genome integration into host DNA
LDL57_16885	COG3561	AntA/AntB antirepressor
LDL57_17015	COG0741	lytic transglycosylase activity
LDL57_17030	COG4633	Protein conserved in bacteria
LDL57_17045	COG2837	iron assimilation
LDL57_17105	COG3344	reverse transcriptase
LDL57_17155	COG1192	Involved in chromosome partitioning
LDL57_17170	COG5464	transposase or invertase
LDL57_17190	COG1525	nuclease
LDL57_17295	COG0741	lytic transglycosylase activity
LDL57_17395	COG3567	Phage-associated protein, HI1409 family
LDL57_17400	COG3077	Addiction module antitoxin, RelB DinJ family
LDL57_17415	COG1783	phage Terminase large subunit
LDL57_17445	COG1484	DNA-dependent DNA replication
LDL57_17455	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LDL57_17480	COG0776	regulation of translation
LDL57_17495	COG2314	TM2 domain
LDL57_17510	COG1192	Involved in chromosome partitioning
LDL57_17530	COG3772	lysozyme
LDL57_17585	COG3567	Phage-associated protein, HI1409 family
LDL57_17635	COG5295	Hep Hag repeat protein