locus-tag	class	description
E3U36_00015	COG4811	Protein of unknown function (DUF986)
E3U36_00020	COG3716	PTS system mannose fructose sorbose family IID component
E3U36_00025	COG3715	PTS system
E3U36_00030	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3U36_00030	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3U36_00040	COG0583	DNA-binding transcription factor activity
E3U36_00050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3U36_00055	COG0616	signal peptide processing
E3U36_00060	COG1028	Short-chain dehydrogenase reductase Sdr
E3U36_00075	COG0009	L-threonylcarbamoyladenylate synthase
E3U36_00080	COG0613	PHP domain protein
E3U36_00090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3U36_00090	COG0512	Glutamine amidotransferase of anthranilate synthase
E3U36_00095	COG0512	Glutamine amidotransferase of anthranilate synthase
E3U36_00095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3U36_00145	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3U36_00175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3U36_00180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3U36_00185	COG1702	phosphate starvation-inducible protein PhoH
E3U36_00190	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E3U36_00195	COG4535	Mg2 and Co2 transporter CorC
E3U36_00200	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E3U36_00210	COG0495	leucyl-tRNA aminoacylation
E3U36_00215	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
E3U36_00220	COG1466	dna polymerase III delta subunit
E3U36_00230	COG0799	negative regulation of ribosome biogenesis
E3U36_00235	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E3U36_00240	COG0768	penicillin binding
E3U36_00245	COG0772	Belongs to the SEDS family
E3U36_00250	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E3U36_00255	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E3U36_00260	COG1686	Belongs to the peptidase S11 family
E3U36_00265	COG2921	Belongs to the UPF0250 family
E3U36_00270	COG0321	lipoyl(octanoyl) transferase activity
E3U36_00275	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E3U36_00290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3U36_00300	COG1780	Probably involved in ribonucleotide reductase function
E3U36_00310	COG1780	Probably involved in ribonucleotide reductase function
E3U36_00325	COG4175	Glycine betaine
E3U36_00330	COG4176	ABC-type proline glycine betaine transport system permease component
E3U36_00335	COG2113	Glycine betaine
E3U36_00355	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E3U36_00355	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E3U36_00360	COG2960	long-chain fatty acid transporting porin activity
E3U36_00375	COG1609	Transcriptional regulator
E3U36_00385	COG0275	rRNA processing
E3U36_00390	COG3116	cell division
E3U36_00395	COG0768	penicillin binding
E3U36_00400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3U36_00405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3U36_00410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3U36_00415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E3U36_00420	COG0772	Belongs to the SEDS family
E3U36_00425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E3U36_00430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3U36_00435	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3U36_00440	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E3U36_00445	COG0849	cell division
E3U36_00450	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E3U36_00455	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E3U36_00470	COG0653	protein targeting
E3U36_00475	COG0494	nUDIX hydrolase
E3U36_00480	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E3U36_00485	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E3U36_00490	COG0237	dephospho-CoA kinase activity
E3U36_00525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E3U36_00530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E3U36_00535	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E3U36_00555	COG2918	glutathione biosynthetic process
E3U36_00580	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3U36_00590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E3U36_00600	COG0335	large ribosomal subunit rRNA binding
E3U36_00610	COG1605	Chorismate mutase
E3U36_00610	COG0287	Prephenate dehydrogenase
E3U36_00625	COG0596	Alpha beta hydrolase
E3U36_00635	COG0814	amino acid
E3U36_00640	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E3U36_00645	COG2855	membrane
E3U36_00655	COG0833	amino acid
E3U36_00665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3U36_00690	COG0531	amino acid
E3U36_00695	COG2925	Exonuclease
E3U36_00730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3U36_00740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E3U36_00745	COG1381	Involved in DNA repair and RecF pathway recombination
E3U36_00750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E3U36_00755	COG0571	ribonuclease III activity
E3U36_00770	COG3086	response to oxidative stress
E3U36_00775	COG3026	antisigma factor binding
E3U36_00785	COG1595	DNA-templated transcription, initiation
E3U36_00805	COG0513	Belongs to the DEAD box helicase family
E3U36_00815	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E3U36_00820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E3U36_00825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E3U36_00835	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3U36_00840	COG2914	Belongs to the UPF0125 (RnfH) family
E3U36_00845	COG2867	negative regulation of translational initiation
E3U36_00850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E3U36_00870	COG3311	Transcriptional regulator
E3U36_00935	COG3596	GTP binding
E3U36_00940	COG2378	regulation of single-species biofilm formation
E3U36_01010	COG0751	glycine-tRNA ligase activity
E3U36_01045	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E3U36_01060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3U36_01065	COG0546	phosphoglycolate phosphatase activity
E3U36_01070	COG0180	Tryptophanyl-tRNA synthetase
E3U36_01080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E3U36_01090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E3U36_01095	COG0009	L-threonylcarbamoyladenylate synthase
E3U36_01110	COG2989	Protein conserved in bacteria
E3U36_01115	COG3108	Peptidase M15
E3U36_01120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3U36_01130	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E3U36_01135	COG0017	Asparaginyl-tRNA synthetase
E3U36_01140	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E3U36_01150	COG0167	dihydroorotate dehydrogenase activity
E3U36_01170	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
E3U36_01180	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E3U36_01195	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E3U36_01205	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E3U36_01210	COG1575	Belongs to the MenA family. Type 1 subfamily
E3U36_01225	COG3074	FtsZ-dependent cytokinesis
E3U36_01245	COG1442	glycosyl transferase family 8
E3U36_01250	COG0515	serine threonine protein kinase
E3U36_01255	COG0438	transferase activity, transferring glycosyl groups
E3U36_01280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3U36_01295	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E3U36_01305	COG1194	a g-specific adenine glycosylase
E3U36_01310	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E3U36_01315	COG0741	lytic transglycosylase activity
E3U36_01355	COG0318	PFAM AMP-dependent synthetase and ligase
E3U36_01380	COG2076	Multidrug Resistance protein
E3U36_01385	COG2076	Multidrug Resistance protein
E3U36_01390	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E3U36_01395	COG1737	Transcriptional regulator
E3U36_01405	COG1737	Transcriptional regulator
E3U36_01420	COG0561	phosphatase activity
E3U36_01425	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E3U36_01475	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3U36_01480	COG0322	excinuclease ABC activity
E3U36_01485	COG2197	response regulator
E3U36_01515	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E3U36_01520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3U36_01525	COG0346	lactoylglutathione lyase activity
E3U36_01550	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E3U36_01555	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E3U36_01565	COG3422	double-strand break repair
E3U36_01570	COG0484	heat shock protein binding
E3U36_01575	COG0443	Heat shock 70 kDa protein
E3U36_01580	COG1584	GPR1 FUN34 yaaH family protein
E3U36_01585	COG0521	Mo-molybdopterin cofactor biosynthetic process
E3U36_01590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3U36_01595	COG3022	response to hydroperoxide
E3U36_01625	COG3045	CreA protein
E3U36_01630	COG3708	Transcriptional regulator
E3U36_01630	COG2207	Transcriptional regulator
E3U36_01650	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
E3U36_01670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E3U36_01695	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E3U36_01700	COG2195	Cleaves the N-terminal amino acid of tripeptides
E3U36_01715	COG1815	bacterial-type flagellum-dependent cell motility
E3U36_01780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3U36_01795	COG1191	sigma factor activity
E3U36_01855	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3U36_01870	COG1987	bacterial-type flagellum assembly
E3U36_01885	COG1454	alcohol dehydrogenase
E3U36_01890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U36_01905	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3U36_01910	COG0564	pseudouridine synthase activity
E3U36_01920	COG0542	response to heat
E3U36_01950	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E3U36_01960	COG1072	(Pantothenic acid kinase))
E3U36_01985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E3U36_01995	COG0250	Participates in transcription elongation, termination and antitermination
E3U36_02000	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E3U36_02005	COG0081	regulation of translation
E3U36_02010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E3U36_02015	COG0222	ribosome binding
E3U36_02020	COG0085	RNA polymerase activity
E3U36_02025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E3U36_02040	COG2022	thiamine diphosphate biosynthetic process
E3U36_02055	COG0352	thiamine-phosphate diphosphorylase activity
E3U36_02065	COG2816	NAD+ diphosphatase activity
E3U36_02095	COG0745	RESPONSE REGULATOR receiver
E3U36_02105	COG1114	Component of the transport system for branched-chain amino acids
E3U36_02110	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
E3U36_02115	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E3U36_02120	COG0343	queuine tRNA-ribosyltransferase activity
E3U36_02125	COG1862	Preprotein translocase
E3U36_02135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3U36_02140	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E3U36_02145	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3U36_02145	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3U36_02150	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E3U36_02155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3U36_02160	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E3U36_02165	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E3U36_02170	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E3U36_02175	COG0142	geranyltranstransferase activity
E3U36_02185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3U36_02185	COG0301	tRNA thio-modification
E3U36_02195	COG1666	GTP binding
E3U36_02205	COG0109	protoheme IX farnesyltransferase activity
E3U36_02210	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E3U36_02215	COG1845	cytochrome c oxidase, subunit III
E3U36_02220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3U36_02225	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E3U36_02250	COG0033	Phosphoglucomutase
E3U36_02255	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E3U36_02265	COG3171	Protein conserved in bacteria
E3U36_02270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E3U36_02305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3U36_02315	COG0758	DNA mediated transformation
E3U36_02325	COG0242	peptide deformylase activity
E3U36_02330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E3U36_02335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E3U36_02335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3U36_02345	COG1970	mechanosensitive ion channel activity
E3U36_02350	COG3036	rescue of stalled ribosome
E3U36_02355	COG0789	Transcriptional regulator
E3U36_02360	COG0203	ribosomal protein L17
E3U36_02370	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E3U36_02380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E3U36_02385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E3U36_02390	COG0201	protein transport
E3U36_02395	COG0200	Binds to the 23S rRNA
E3U36_02400	COG1841	ribosomal large subunit assembly
E3U36_02405	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E3U36_02410	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E3U36_02415	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E3U36_02420	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E3U36_02425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E3U36_02430	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E3U36_02440	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E3U36_02445	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E3U36_02455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E3U36_02470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E3U36_02475	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E3U36_02480	COG0089	rRNA binding
E3U36_02485	COG0088	Forms part of the polypeptide exit tunnel
E3U36_02490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E3U36_02495	COG0051	transcription antitermination factor activity, RNA binding
E3U36_02510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E3U36_02515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E3U36_02520	COG0049	tRNA binding
E3U36_02525	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E3U36_02535	COG2923	Belongs to the DsrF TusC family
E3U36_02540	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E3U36_02545	COG2964	Protein conserved in bacteria
E3U36_02550	COG0545	Peptidyl-prolyl cis-trans isomerase
E3U36_02665	COG3772	lysozyme
E3U36_02695	COG1484	DNA-dependent DNA replication
E3U36_02790	COG3023	N-Acetylmuramoyl-L-alanine amidase
E3U36_02825	COG1124	(ABC) transporter
E3U36_02840	COG2974	May be involved in recombination
E3U36_02890	COG3530	Putative quorum-sensing-regulated virulence factor
E3U36_02905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3U36_02910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E3U36_02915	COG3115	cell septum assembly
E3U36_02925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3U36_02930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3U36_02935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3U36_02940	COG2190	(PTS) system
E3U36_02960	COG0408	coproporphyrinogen oxidase activity
E3U36_02965	COG1160	GTP binding
E3U36_02970	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3U36_02975	COG2976	Protein conserved in bacteria
E3U36_02980	COG0124	histidyl-tRNA synthetase
E3U36_02985	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E3U36_03005	COG0105	UTP biosynthetic process
E3U36_03020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3U36_03025	COG2975	iron-sulfur cluster assembly
E3U36_03030	COG0633	Ferredoxin
E3U36_03040	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E3U36_03050	COG4991	sh3 domain protein
E3U36_03060	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E3U36_03065	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E3U36_03070	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E3U36_03080	COG0358	DNA primase activity
E3U36_03100	COG0501	Belongs to the peptidase M48B family
E3U36_03125	COG2966	Psort location CytoplasmicMembrane, score
E3U36_03130	COG3610	response to peptide
E3U36_03140	COG2356	endonuclease I
E3U36_03155	COG0012	GTP binding
E3U36_03170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E3U36_03175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E3U36_03180	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E3U36_03185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E3U36_03190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E3U36_03195	COG2890	protein-(glutamine-N5) methyltransferase activity
E3U36_03200	COG2912	Transglutaminase-like superfamily
E3U36_03205	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E3U36_03210	COG1242	4 iron, 4 sulfur cluster binding
E3U36_03220	COG3381	protein complex oligomerization
E3U36_03270	COG0534	Mate efflux family protein
E3U36_03275	COG0307	riboflavin synthase, alpha
E3U36_03295	COG0583	DNA-binding transcription factor activity
E3U36_03300	COG1609	Transcriptional regulator
E3U36_03305	COG0018	arginyl-trna synthetase
E3U36_03315	COG0500	methyltransferase
E3U36_03320	COG2226	methyltransferase
E3U36_03325	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E3U36_03330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E3U36_03335	COG0494	nUDIX hydrolase
E3U36_03340	COG0217	transcriptional regulatory protein
E3U36_03345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E3U36_03350	COG0632	four-way junction helicase activity
E3U36_03355	COG2255	four-way junction helicase activity
E3U36_03375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E3U36_03390	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E3U36_03405	COG0567	Dehydrogenase, E1 component
E3U36_03410	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3U36_03420	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3U36_03425	COG1271	oxidase subunit
E3U36_03430	COG1294	oxidase, subunit
E3U36_03435	COG4890	Cyd operon protein YbgT
E3U36_03450	COG0811	peptide transport
E3U36_03455	COG0848	biopolymer transport protein
E3U36_03460	COG3064	Membrane
E3U36_03465	COG0823	Involved in the tonB-independent uptake of proteins
E3U36_03470	COG2885	chlorophyll binding
E3U36_03475	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E3U36_03490	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E3U36_03510	COG0588	phosphoglycerate mutase activity
E3U36_03535	COG2823	Periplasmic or secreted lipoprotein
E3U36_03540	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E3U36_03545	COG0792	nuclease activity
E3U36_03555	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E3U36_03620	COG2259	Doxx family
E3U36_03640	COG0586	Pfam SNARE associated Golgi protein
E3U36_03645	COG0861	Integral membrane protein TerC family
E3U36_03650	COG0582	viral genome integration into host DNA
E3U36_03660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E3U36_03700	COG0215	cysteine-tRNA ligase activity
E3U36_03705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E3U36_03710	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3U36_03730	COG0300	oxidoreductase activity
E3U36_03735	COG3118	belongs to the thioredoxin family
E3U36_03755	COG2217	Heavy metal translocating P-type atpase
E3U36_03760	COG3735	TraB family
E3U36_03780	COG4232	protein-disulfide reductase activity
E3U36_03785	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E3U36_03795	COG3030	protein affecting phage T7 exclusion by the F plasmid
E3U36_03800	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E3U36_03805	COG0459	protein refolding
E3U36_03820	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E3U36_03860	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E3U36_03865	COG0706	membrane insertase activity
E3U36_03870	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E3U36_03875	COG0594	ribonuclease P activity
E3U36_03880	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E3U36_03885	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E3U36_03890	COG0592	DNA-directed DNA polymerase activity
E3U36_03900	COG0187	DNA topoisomerase II activity
E3U36_03905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3U36_03915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E3U36_03920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E3U36_03925	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E3U36_03930	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E3U36_03940	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E3U36_03945	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E3U36_03950	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E3U36_03960	COG0356	it plays a direct role in the translocation of protons across the membrane
E3U36_03965	COG3312	ion transport
E3U36_03990	COG0445	tRNA wobble uridine modification
E3U36_03995	COG0716	FMN binding
E3U36_04000	COG1522	sequence-specific DNA binding
E3U36_04005	COG2502	aspartate--ammonia ligase
E3U36_04055	COG0583	DNA-binding transcription factor activity
E3U36_04060	COG3085	chromosome segregation
E3U36_04080	COG0028	Belongs to the TPP enzyme family
E3U36_04105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E3U36_04120	COG0210	DNA helicase
E3U36_04125	COG0248	Ppx GppA phosphatase
E3U36_04130	COG0513	Belongs to the DEAD box helicase family
E3U36_04135	COG3118	belongs to the thioredoxin family
E3U36_04145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3U36_04155	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3U36_04160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E3U36_04165	COG1088	dTDP-glucose 4,6-dehydratase activity
E3U36_04170	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E3U36_04175	COG0456	acetyltransferase
E3U36_04180	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E3U36_04185	COG2244	polysaccharide biosynthetic process
E3U36_04190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E3U36_04200	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
E3U36_04230	COG3071	HemY protein
E3U36_04235	COG2959	enzyme of heme biosynthesis
E3U36_04240	COG1587	Uroporphyrinogen-III synthase
E3U36_04245	COG0181	hydroxymethylbilane synthase activity
E3U36_04255	COG1965	Belongs to the frataxin family
E3U36_04265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E3U36_04270	COG3159	Protein conserved in bacteria
E3U36_04280	COG1011	Hydrolase
E3U36_04285	COG0210	DNA helicase
E3U36_04310	COG0514	ATP-dependent DNA helicase (RecQ)
E3U36_04325	COG2267	carboxylic ester hydrolase activity
E3U36_04330	COG0561	phosphatase activity
E3U36_04340	COG3121	Chaperone
E3U36_04345	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E3U36_04360	COG0149	triose-phosphate isomerase activity
E3U36_04380	COG2814	Major facilitator Superfamily
E3U36_04410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3U36_04415	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E3U36_04420	COG1519	Transferase
E3U36_04430	COG0859	PFAM glycosyl transferase family 9
E3U36_04435	COG0859	PFAM glycosyl transferase family 9
E3U36_04440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U36_04445	COG2861	carbohydrate metabolic process
E3U36_04450	COG4942	peptidase
E3U36_04455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3U36_04460	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E3U36_04465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E3U36_04475	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E3U36_04495	COG2205	protein histidine kinase activity
E3U36_04500	COG0745	RESPONSE REGULATOR receiver
E3U36_04505	COG3678	ATP-independent chaperone mediated protein folding
E3U36_04660	COG1530	ribonuclease E activity
E3U36_04665	COG0564	pseudouridine synthase activity
E3U36_04670	COG0424	maF-like protein
E3U36_04680	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E3U36_04685	COG0416	fatty acid biosynthetic process
E3U36_04690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E3U36_04695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E3U36_04700	COG1028	Short-chain dehydrogenase reductase Sdr
E3U36_04710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3U36_04715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3U36_04720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E3U36_04725	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E3U36_04730	COG0470	DNA polymerase III
E3U36_04735	COG0084	hydrolase, TatD family'
E3U36_04740	COG0537	adenosine 5'-monophosphoramidase activity
E3U36_04745	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
E3U36_04780	COG3066	DNA modification
E3U36_04790	COG0010	Belongs to the arginase family
E3U36_04805	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E3U36_04810	COG3091	SprT-like family
E3U36_04850	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3U36_04860	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E3U36_04865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3U36_04875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3U36_04885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3U36_04885	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3U36_04890	COG1105	Belongs to the carbohydrate kinase PfkB family
E3U36_04905	COG1715	Restriction endonuclease
E3U36_05025	COG0142	geranyltranstransferase activity
E3U36_05030	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E3U36_05035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E3U36_05040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E3U36_05050	COG1534	Rna-binding protein
E3U36_05065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E3U36_05070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3U36_05075	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3U36_05095	COG0779	Required for maturation of 30S ribosomal subunits
E3U36_05100	COG0195	Participates in both transcription termination and antitermination
E3U36_05105	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E3U36_05110	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E3U36_05115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E3U36_05125	COG1185	polyribonucleotide nucleotidyltransferase activity
E3U36_05170	COG0826	peptidase U32
E3U36_05185	COG3153	acetyltransferase
E3U36_05200	COG3787	Belongs to the UPF0306 family
E3U36_05205	COG0602	queuosine metabolic process
E3U36_05220	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E3U36_05230	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E3U36_05235	COG0525	valine-tRNA ligase activity
E3U36_05240	COG2927	DNA polymerase III (CHI subunit)
E3U36_05245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3U36_05250	COG0795	lipopolysaccharide-transporting ATPase activity
E3U36_05255	COG0795	lipopolysaccharide-transporting ATPase activity
E3U36_05260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3U36_05280	COG3423	Transcriptional regulator
E3U36_05290	COG1438	arginine binding
E3U36_05310	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E3U36_05320	COG4783	chaperone-mediated protein folding
E3U36_05325	COG0628	permease
E3U36_05330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E3U36_05350	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E3U36_05370	COG2707	UPF0756 membrane protein
E3U36_05375	COG1444	tRNA N-acetyltransferase activity
E3U36_05390	COG2832	Protein of unknown function (DUF454)
E3U36_05395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3U36_05420	COG3188	usher protein
E3U36_05430	COG3188	usher protein
E3U36_05445	COG0579	oxidoreductase
E3U36_05475	COG3683	transport system, periplasmic component
E3U36_05495	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
E3U36_05505	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E3U36_05520	COG3034	peptidoglycan biosynthetic process
E3U36_05560	COG1477	protein flavinylation
E3U36_05565	COG2991	Protein conserved in bacteria
E3U36_05580	COG0306	phosphate transporter
E3U36_05585	COG2081	HI0933 family
E3U36_05600	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E3U36_05605	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E3U36_05615	COG0626	cystathionine gamma-synthase activity
E3U36_05620	COG1757	Na H antiporter
E3U36_05625	COG0113	porphobilinogen synthase activity
E3U36_05665	COG1301	dicarboxylic acid transport
E3U36_05680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E3U36_05685	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E3U36_05695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3U36_05700	COG0328	RNA-DNA hybrid ribonuclease activity
E3U36_05705	COG2226	methyltransferase
E3U36_05710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3U36_05715	COG0741	lytic transglycosylase activity
E3U36_05715	COG1388	LysM domain
E3U36_05725	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E3U36_05740	COG0668	transmembrane transport
E3U36_05770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3U36_05775	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3U36_05780	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E3U36_05800	COG1448	Aminotransferase
E3U36_05820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3U36_05870	COG2207	Transcriptional regulator
E3U36_05870	COG3708	Transcriptional regulator
E3U36_05885	COG1113	amino acid transport
E3U36_05915	COG2610	gluconate transmembrane transporter activity
E3U36_05925	COG0735	belongs to the Fur family
E3U36_05940	COG2937	Belongs to the GPAT DAPAT family
E3U36_05945	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E3U36_05955	COG0166	Belongs to the GPI family
E3U36_05960	COG0527	aspartate kinase activity
E3U36_05980	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E3U36_06015	COG0354	folic acid binding
E3U36_06050	COG4974	Belongs to the 'phage' integrase family
E3U36_06055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3U36_06060	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E3U36_06070	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E3U36_06075	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E3U36_06105	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E3U36_06120	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3U36_06135	COG0839	Belongs to the complex I subunit 6 family
E3U36_06145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3U36_06155	COG1007	ATP synthesis coupled electron transport
E3U36_06180	COG1441	menaquinone biosynthetic process
E3U36_06200	COG0814	amino acid
E3U36_06210	COG0633	Ferredoxin
E3U36_06215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3U36_06220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3U36_06225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3U36_06235	COG0784	Response regulator, receiver
E3U36_06235	COG2205	protein histidine kinase activity
E3U36_06245	COG2197	response regulator
E3U36_06250	COG0642	Histidine kinase
E3U36_06250	COG2198	Histidine kinase
E3U36_06270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E3U36_06275	COG3081	Nucleoid-associated protein
E3U36_06285	COG3083	sulfuric ester hydrolase activity
E3U36_06330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3U36_06355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E3U36_06360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3U36_06375	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E3U36_06380	COG1956	GAF domain-containing protein
E3U36_06410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3U36_06415	COG3140	Belongs to the UPF0181 family
E3U36_06445	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E3U36_06455	COG0084	hydrolase, TatD family'
E3U36_06460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3U36_06470	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E3U36_06475	COG0813	purine-nucleoside phosphorylase activity
E3U36_06495	COG0560	Phosphoserine phosphatase
E3U36_06510	COG0488	(ABC) transporter
E3U36_06550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3U36_06560	COG3210	domain, Protein
E3U36_06590	COG3479	Phenolic acid decarboxylase
E3U36_06595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E3U36_06615	COG1309	transcriptional regulator
E3U36_06685	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E3U36_06720	COG3120	sequence-specific DNA binding
E3U36_06725	COG1067	ATP-dependent peptidase activity
E3U36_06730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E3U36_06735	COG3009	Protein conserved in bacteria
E3U36_06750	COG0488	(ABC) transporter
E3U36_06755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E3U36_06755	COG0116	Belongs to the methyltransferase superfamily
E3U36_06775	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E3U36_06780	COG3383	formate dehydrogenase (NAD+) activity
E3U36_06780	COG0243	molybdopterin cofactor binding
E3U36_06785	COG0243	molybdopterin cofactor binding
E3U36_06785	COG3383	formate dehydrogenase (NAD+) activity
E3U36_06795	COG0437	4 iron, 4 sulfur cluster binding
E3U36_06800	COG2864	formate dehydrogenase
E3U36_06875	COG3188	usher protein
E3U36_06890	COG0688	phosphatidylethanolamine metabolic process
E3U36_06895	COG1162	GTPase activity
E3U36_06900	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E3U36_06915	COG0802	atpase or kinase
E3U36_06920	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3U36_06925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E3U36_06930	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E3U36_06935	COG1923	regulation of RNA biosynthetic process
E3U36_06940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3U36_06945	COG0330	HflC and HflK could
E3U36_06950	COG0330	HflC and HflK could
E3U36_06955	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E3U36_06960	COG1959	2 iron, 2 sulfur cluster binding
E3U36_06965	COG0557	exoribonuclease II activity
E3U36_06970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3U36_06975	COG0360	Binds together with S18 to 16S ribosomal RNA
E3U36_06980	COG2965	DNA replication, synthesis of RNA primer
E3U36_06985	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E3U36_06990	COG0359	binds to the 23S rRNA
E3U36_07010	COG3590	peptidase
E3U36_07050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3U36_07085	COG0019	diaminopimelate decarboxylase activity
E3U36_07115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3U36_07125	COG1120	ATPase activity
E3U36_07190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3U36_07190	COG4651	solute:proton antiporter activity
E3U36_07210	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E3U36_07220	COG0671	phosphoesterase, PA-phosphatase related
E3U36_07250	COG4160	amino acid transport
E3U36_07255	COG4215	(ABC) transporter
E3U36_07260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3U36_07265	COG1126	abc transporter atp-binding protein
E3U36_07295	COG1278	Cold shock
E3U36_07300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E3U36_07305	COG0542	response to heat
E3U36_07310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E3U36_07315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E3U36_07320	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E3U36_07330	COG0492	ferredoxin-NADP+ reductase activity
E3U36_07340	COG3107	peptidoglycan biosynthetic process
E3U36_07340	COG1674	ftsk spoiiie
E3U36_07345	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E3U36_07350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3U36_07355	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E3U36_07370	COG0252	asparaginase activity
E3U36_07375	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E3U36_07380	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E3U36_07385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E3U36_07390	COG0539	negative regulation of cytoplasmic translation
E3U36_07395	COG0776	regulation of translation
E3U36_07405	COG0842	Transport permease protein
E3U36_07410	COG1131	(ABC) transporter
E3U36_07440	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E3U36_07445	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E3U36_07465	COG0534	Mate efflux family protein
E3U36_07470	COG0523	cobalamin synthesis protein
E3U36_07475	COG2879	small protein
E3U36_07500	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E3U36_07515	COG4942	peptidase
E3U36_07515	COG1388	LysM domain
E3U36_07520	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E3U36_07525	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E3U36_07540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E3U36_07545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E3U36_07575	COG3021	interspecies interaction between organisms
E3U36_07615	COG0138	bifunctional purine biosynthesis protein purh
E3U36_07635	COG3068	Protein conserved in bacteria
E3U36_07640	COG1515	deoxyribonuclease V activity
E3U36_07675	COG0114	fumarate hydratase activity
E3U36_07685	COG5339	Protein conserved in bacteria
E3U36_07705	COG4657	Part of a membrane complex involved in electron transport
E3U36_07715	COG4656	Part of a membrane complex involved in electron transport
E3U36_07725	COG4659	FMN binding
E3U36_07735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3U36_07740	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
E3U36_07765	COG0284	orotidine-5'-phosphate decarboxylase activity
E3U36_07770	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E3U36_07775	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
E3U36_07780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E3U36_07795	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E3U36_07800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3U36_07835	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E3U36_07850	COG0805	protein transport
E3U36_07855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3U36_07875	COG2226	methyltransferase
E3U36_07880	COG1322	Protein conserved in bacteria
E3U36_07885	COG0586	Pfam SNARE associated Golgi protein
E3U36_07920	COG1028	Short-chain dehydrogenase reductase Sdr
E3U36_07920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3U36_07920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U36_07920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U36_07920	COG3321	synthase
E3U36_07935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U36_07935	COG2226	methyltransferase
E3U36_07935	COG3433	isochorismatase activity
E3U36_07970	COG0742	ribosomal rna small subunit methyltransferase
E3U36_08025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3U36_08040	COG0583	DNA-binding transcription factor activity
E3U36_08070	COG3092	negative regulation of chromosome organization
E3U36_08075	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E3U36_08080	COG0857	belongs to the CobB CobQ family
E3U36_08080	COG0280	phosphate acetyltransferase
E3U36_08135	COG3691	Protein conserved in bacteria
E3U36_08140	COG0183	Belongs to the thiolase family
E3U36_08145	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3U36_08145	COG1024	Enoyl-CoA hydratase
E3U36_08155	COG2840	Smr protein MutS2
E3U36_08170	COG3101	peptidyl-lysine hydroxylation
E3U36_08190	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E3U36_08190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3U36_08200	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E3U36_08200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3U36_08205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3U36_08215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3U36_08225	COG0101	tRNA pseudouridine synthase activity
E3U36_08230	COG0586	Pfam SNARE associated Golgi protein
E3U36_08235	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E3U36_08240	COG0285	dihydrofolate synthase activity
E3U36_08245	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E3U36_08250	COG1286	toxin biosynthetic process
E3U36_08260	COG0163	prenyltransferase activity
E3U36_08275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3U36_08280	COG1074	ATP-dependent DNA helicase activity
E3U36_08290	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E3U36_08325	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E3U36_08330	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E3U36_08335	COG0494	nUDIX hydrolase
E3U36_08340	COG4143	(ABC) transporter
E3U36_08345	COG1178	ABC-type Fe3 transport system permease component
E3U36_08350	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E3U36_08365	COG0564	pseudouridine synthase activity
E3U36_08370	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E3U36_08375	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E3U36_08380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3U36_08385	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E3U36_08390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E3U36_08395	COG2967	ApaG domain
E3U36_08400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E3U36_08415	COG0204	Acyl-transferase
E3U36_08420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3U36_08435	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E3U36_08450	COG5463	Belongs to the UPF0441 family
E3U36_08455	COG0754	glutathionylspermidine amidase activity
E3U36_08465	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E3U36_08485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E3U36_08490	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E3U36_08500	COG2003	Belongs to the UPF0758 family
E3U36_08505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3U36_08510	COG0756	dUTP diphosphatase activity
E3U36_08515	COG1309	transcriptional regulator
E3U36_08520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E3U36_08525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E3U36_08530	COG1561	YicC-like family, N-terminal region
E3U36_08565	COG0205	6-phosphofructokinase activity
E3U36_08570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E3U36_08575	COG1349	DNA-binding transcription factor activity
E3U36_08580	COG0705	Rhomboid family
E3U36_08585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3U36_08595	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E3U36_08595	COG0316	Belongs to the HesB IscA family
E3U36_08605	COG0596	Alpha beta hydrolase
E3U36_08620	COG1918	ferrous iron import across plasma membrane
E3U36_08635	COG2183	response to ionizing radiation
E3U36_08640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3U36_08645	COG0745	RESPONSE REGULATOR receiver
E3U36_08660	COG0573	inorganic phosphate transmembrane transporter activity
E3U36_08680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3U36_08685	COG0704	Plays a role in the regulation of phosphate uptake
E3U36_08705	COG0765	amino acid transport
E3U36_08710	COG2252	PERMEase
E3U36_08715	COG3078	GTPase activator activity
E3U36_08725	COG3078	GTPase activator activity
E3U36_08760	COG2860	membrane
E3U36_08765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E3U36_08770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E3U36_08785	COG0194	GDP metabolic process
E3U36_08790	COG1758	RNA polymerase activity
E3U36_08795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3U36_08800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3U36_08805	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E3U36_08810	COG0786	glutamate:sodium symporter activity
E3U36_08840	COG2813	Specifically methylates the guanine in position
E3U36_08855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3U36_08890	COG0189	ligase activity
E3U36_08895	COG1678	Uncharacterized ACR, COG1678
E3U36_08910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E3U36_08915	COG0762	integral membrane protein
E3U36_08920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E3U36_08925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3U36_08955	COG0488	(ABC) transporter
E3U36_08980	COG0429	hydrolase of the alpha beta-hydrolase fold
E3U36_08990	COG3954	Phosphoribulokinase
E3U36_09005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3U36_09030	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
E3U36_09035	COG0538	isocitrate dehydrogenase activity
E3U36_09040	COG1187	pseudouridine synthase activity
E3U36_09050	COG0482	sulfurtransferase activity
E3U36_09055	COG2915	High frequency lysogenization protein hflD homolog
E3U36_09060	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E3U36_09070	COG0745	RESPONSE REGULATOR receiver
E3U36_09095	COG4591	ABC-type transport system involved in lipoprotein release permease component
E3U36_09100	COG1136	(ABC) transporter
E3U36_09105	COG4591	ABC-type transport system involved in lipoprotein release permease component
E3U36_09115	COG1252	NADH dehydrogenase
E3U36_09125	COG0583	DNA-binding transcription factor activity
E3U36_09150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E3U36_09165	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E3U36_09165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3U36_09170	COG2204	response regulator
E3U36_09175	COG3170	Tfp pilus assembly protein FimV
E3U36_09180	COG2205	protein histidine kinase activity
E3U36_09190	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E3U36_09205	COG2194	sulfuric ester hydrolase activity
E3U36_09215	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E3U36_09225	COG2969	positive regulation of protein catabolic process
E3U36_09230	COG0625	glutathione transferase activity
E3U36_09240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E3U36_09250	COG3105	Protein conserved in bacteria
E3U36_09255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3U36_09260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3U36_09265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E3U36_09270	COG5007	Belongs to the BolA IbaG family
E3U36_09280	COG2854	intermembrane phospholipid transfer
E3U36_09285	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E3U36_09290	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E3U36_09295	COG1127	ABC transporter
E3U36_09300	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E3U36_09300	COG0517	IMP dehydrogenase activity
E3U36_09305	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E3U36_09310	COG3117	lipopolysaccharide transmembrane transporter activity
E3U36_09315	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E3U36_09320	COG1137	ATPase activity
E3U36_09325	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E3U36_09330	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E3U36_09340	COG1660	Displays ATPase and GTPase activities
E3U36_09345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3U36_09355	COG3028	Belongs to the UPF0307 family
E3U36_09375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3U36_09380	COG3164	Protein of unknown function
E3U36_09385	COG1530	ribonuclease E activity
E3U36_09390	COG0424	maF-like protein
E3U36_09395	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E3U36_09400	COG1792	Involved in formation and maintenance of cell shape
E3U36_09405	COG1077	Cell shape determining protein MreB Mrl
E3U36_09420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E3U36_09425	COG0511	ligase activity, forming carbon-carbon bonds
E3U36_09430	COG0439	Biotin carboxylase
E3U36_09435	COG3924	membrane
E3U36_09440	COG4145	pantothenate transmembrane transporter activity
E3U36_09445	COG2264	protein methyltransferase activity
E3U36_09450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3U36_09455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3U36_09470	COG2177	Part of the ABC transporter FtsEX involved in
E3U36_09475	COG2884	Cell division ATP-binding protein ftsE
E3U36_09480	COG0552	protein localization to endoplasmic reticulum
E3U36_09485	COG0742	ribosomal rna small subunit methyltransferase
E3U36_09490	COG3776	membrane
E3U36_09500	COG3714	YhhN family
E3U36_09510	COG0425	Belongs to the sulfur carrier protein TusA family
E3U36_09515	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E3U36_09580	COG0583	DNA-binding transcription factor activity
E3U36_09595	COG0628	permease
E3U36_09610	COG0316	Belongs to the HesB IscA family
E3U36_09615	COG0719	Fe-S assembly protein
E3U36_09620	COG0396	ATPase activity
E3U36_09625	COG0719	Fe-S assembly protein
E3U36_09630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3U36_09635	COG2166	iron-sulfur cluster assembly
E3U36_09640	COG1388	LysM domain
E3U36_09640	COG1376	ErfK ybiS ycfS ynhG family protein
E3U36_09645	COG4238	major outer membrane lipoprotein
E3U36_09650	COG0469	pyruvate kinase activity
E3U36_09670	COG1560	Kdo2-lipid A biosynthetic process
E3U36_09680	COG0739	heme binding
E3U36_09685	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E3U36_09690	COG1121	(ABC) transporter
E3U36_09695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3U36_09700	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E3U36_09710	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E3U36_09715	COG2894	cell division
E3U36_09720	COG0850	regulation of cytokinetic process
E3U36_09725	COG3100	YcgL domain-containing protein
E3U36_09740	COG0179	Fumarylacetoacetate (FAA) hydrolase
E3U36_09745	COG2983	Belongs to the UPF0260 family
E3U36_09765	COG2911	Protein conserved in bacteria
E3U36_09775	COG2911	Protein conserved in bacteria
E3U36_09785	COG3784	Protein of unknown function (DUF1318)
E3U36_09805	COG3188	usher protein
E3U36_09835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3U36_09860	COG0604	alcohol dehydrogenase
E3U36_09860	COG1028	Short-chain dehydrogenase reductase Sdr
E3U36_09860	COG3321	synthase
E3U36_09870	COG0450	alkyl hydroperoxide reductase
E3U36_09905	COG1760	l-serine dehydratase
E3U36_09910	COG0814	amino acid
E3U36_09920	COG1196	nuclear chromosome segregation
E3U36_09920	COG3264	Mechanosensitive ion channel
E3U36_09925	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E3U36_09930	COG1309	transcriptional regulator
E3U36_09935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3U36_09940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3U36_09980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3U36_09990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E3U36_09995	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E3U36_10000	COG0740	serine-type endopeptidase activity
E3U36_10010	COG0271	Belongs to the BolA IbaG family
E3U36_10035	COG0519	Catalyzes the synthesis of GMP from XMP
E3U36_10035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E3U36_10040	COG0516	GMP reductase activity
E3U36_10040	COG0517	IMP dehydrogenase activity
E3U36_10065	COG0281	malic enzyme
E3U36_10065	COG0280	phosphate acetyltransferase
E3U36_10080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3U36_10195	COG0418	dihydroorotase activity
E3U36_10225	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E3U36_10230	COG1959	2 iron, 2 sulfur cluster binding
E3U36_10240	COG0822	iron-sulfur transferase activity
E3U36_10245	COG0316	Belongs to the HesB IscA family
E3U36_10270	COG2771	luxR family
E3U36_10280	COG5464	transposase or invertase
E3U36_10330	COG0471	metal ion transport
E3U36_10340	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E3U36_10350	COG2982	Protein involved in outer membrane biogenesis
E3U36_10355	COG0717	Belongs to the dCTP deaminase family
E3U36_10365	COG0489	protein tyrosine kinase activity
E3U36_10370	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3U36_10370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3U36_10375	COG1380	Effector of murein hydrolase LrgA
E3U36_10380	COG1346	cytolysis
E3U36_10385	COG2949	membrane
E3U36_10390	COG2311	Membrane
E3U36_10395	COG2311	Membrane
E3U36_10410	COG0302	gtp cyclohydrolase
E3U36_10425	COG0303	'Molybdopterin
E3U36_10430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3U36_10455	COG0783	Belongs to the Dps family
E3U36_10460	COG2824	Alkylphosphonate utilization operon protein PhnA
E3U36_10470	COG2897	thiosulfate sulfurtransferase activity
E3U36_10475	COG2261	transglycosylase associated protein
E3U36_10510	COG0670	Belongs to the BI1 family
E3U36_10525	COG0315	cyclic pyranopterin monophosphate synthase activity
E3U36_10535	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E3U36_10540	COG0556	nucleotide-excision repair
E3U36_10570	COG2706	6-phosphogluconolactonase activity
E3U36_10590	COG3104	oligopeptide transport
E3U36_10620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E3U36_10625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3U36_10630	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E3U36_10640	COG2239	Acts as a magnesium transporter
E3U36_10655	COG0159	tryptophan synthase activity
E3U36_10675	COG2917	probably involved in intracellular septation
E3U36_10685	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E3U36_10700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3U36_10710	COG2095	MarC family integral membrane protein
E3U36_10735	COG0745	RESPONSE REGULATOR receiver
E3U36_10740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E3U36_10770	COG1435	thymidine kinase activity
E3U36_10785	COG0788	formyltetrahydrofolate deformylase activity
E3U36_10805	COG0708	Exodeoxyribonuclease III
E3U36_10810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3U36_10820	COG0778	Nitroreductase
E3U36_10825	COG0616	signal peptide processing
E3U36_10835	COG3139	Protein of unknown function (DUF1315)
E3U36_10840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3U36_10900	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E3U36_10910	COG3768	UPF0283 membrane protein
E3U36_10925	COG1983	PspC domain protein
E3U36_10945	COG1842	Phage shock protein A
E3U36_10955	COG4166	transmembrane transport
E3U36_10960	COG4168	peptide transport system, permease
E3U36_10965	COG4171	peptide transport system, permease
E3U36_10970	COG4172	Belongs to the ABC transporter superfamily
E3U36_10975	COG4172	Belongs to the ABC transporter superfamily
E3U36_10980	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E3U36_11045	COG1560	Kdo2-lipid A biosynthetic process
E3U36_11065	COG0563	adenylate kinase activity
E3U36_11070	COG0326	Molecular chaperone. Has ATPase activity
E3U36_11080	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E3U36_11085	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E3U36_11090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E3U36_11115	COG0848	biopolymer transport protein
E3U36_11135	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E3U36_11140	COG0505	Belongs to the CarA family
E3U36_11145	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E3U36_11155	COG1047	Peptidyl-prolyl cis-trans
E3U36_11160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E3U36_11165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E3U36_11170	COG0196	riboflavin kinase activity
E3U36_11175	COG0268	Binds directly to 16S ribosomal RNA
E3U36_11190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E3U36_11220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3U36_11230	COG1803	Methylglyoxal synthase
E3U36_11240	COG3785	DNA binding
E3U36_11245	COG1254	Belongs to the acylphosphatase family
E3U36_11250	COG2920	part of a sulfur-relay system
E3U36_11285	COG0716	FMN binding
E3U36_11290	COG0735	belongs to the Fur family
E3U36_11315	COG0612	Peptidase, M16
E3U36_11320	COG1295	ribonuclease BN
E3U36_11350	COG1317	bacterial-type flagellum organization
E3U36_11355	COG3137	Salt-induced outer membrane protein
E3U36_11390	COG0589	response to stress
E3U36_11420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3U36_11425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3U36_11430	COG0006	proline dipeptidase activity
E3U36_11435	COG3079	Belongs to the UPF0149 family
E3U36_11440	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E3U36_11465	COG0148	phosphopyruvate hydratase activity
E3U36_11470	COG0504	CTP synthase activity
E3U36_11475	COG3956	TIGRFAM MazG family protein
E3U36_11485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3U36_11500	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E3U36_11505	COG0316	Belongs to the HesB IscA family
E3U36_11510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E3U36_11515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3U36_11520	COG1489	DNA binding
E3U36_11540	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3U36_11555	COG2333	competence protein COMEC
E3U36_11555	COG0658	competence protein
E3U36_11560	COG0658	competence protein
E3U36_11560	COG2333	competence protein COMEC
E3U36_11565	COG1132	(ABC) transporter
E3U36_11570	COG1663	tetraacyldisaccharide 4'-kinase activity
E3U36_11575	COG1278	Cold shock
E3U36_11580	COG2835	tetraacyldisaccharide 4'-kinase activity
E3U36_11585	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E3U36_11600	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
E3U36_11605	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E3U36_11610	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E3U36_11660	COG1611	Belongs to the LOG family
E3U36_11665	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E3U36_11665	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E3U36_11680	COG0564	pseudouridine synthase activity
E3U36_11695	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E3U36_11710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E3U36_11715	COG0528	UMP kinase activity
E3U36_11720	COG0233	cytoplasmic translational termination
E3U36_11725	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E3U36_11730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E3U36_11735	COG0575	Belongs to the CDS family
E3U36_11740	COG0750	zinc metalloprotease
E3U36_11745	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3U36_11750	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
E3U36_11755	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3U36_11760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E3U36_11765	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3U36_11770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E3U36_11780	COG0825	malonyl-CoA metabolic process
E3U36_11785	COG0037	tRNA processing
E3U36_11790	COG4568	rho-dependent transcription termination
E3U36_11795	COG3015	lipoprotein NlpE involved in copper resistance
E3U36_11800	COG0442	prolyl-tRNA aminoacylation
E3U36_11805	COG1720	tRNA m6t6A37 methyltransferase activity
E3U36_11825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E3U36_11830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E3U36_11870	COG1988	membrane-bound metal-dependent
E3U36_11875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3U36_11895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3U36_11910	COG0803	Belongs to the bacterial solute-binding protein 9 family
E3U36_11920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E3U36_11925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E3U36_11930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E3U36_11935	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E3U36_11945	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E3U36_11950	COG0072	phenylalanine-tRNA ligase activity
E3U36_11950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3U36_11955	COG0776	regulation of translation
E3U36_11960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E3U36_11965	COG0463	Glycosyl transferase, family 2
E3U36_11970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U36_11970	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E3U36_11975	COG0726	polysaccharide deacetylase
E3U36_11980	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E3U36_11985	COG2076	Multidrug Resistance protein
E3U36_11990	COG2076	Multidrug Resistance protein
E3U36_11995	COG0791	NLP P60 protein
E3U36_12155	COG0071	Belongs to the small heat shock protein (HSP20) family
E3U36_12175	COG1278	Cold shock