locus-tag	class	description
AS189_00035	COG2801	Transposase and inactivated derivatives
AS189_00060	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AS189_00065	COG0366	Alpha amylase catalytic
AS189_00070	COG0366	Alpha amylase catalytic
AS189_00090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS189_00110	COG0215	cysteine-tRNA ligase activity
AS189_00115	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AS189_00120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AS189_00150	COG5002	protein histidine kinase activity
AS189_00155	COG0704	Plays a role in the regulation of phosphate uptake
AS189_00160	COG0588	phosphoglycerate mutase activity
AS189_00185	COG1121	(ABC) transporter
AS189_00190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AS189_00205	COG0803	Belongs to the bacterial solute-binding protein 9 family
AS189_00210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AS189_00215	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AS189_00235	COG3842	ATPase activity
AS189_00265	COG1966	Carbon starvation protein
AS189_00315	COG2186	Transcriptional regulator
AS189_00330	COG1879	ABC-type sugar transport system periplasmic component
AS189_00335	COG1172	Belongs to the binding-protein-dependent transport system permease family
AS189_00375	COG1028	Short-chain dehydrogenase reductase Sdr
AS189_00380	COG0514	ATP-dependent DNA helicase (RecQ)
AS189_00385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AS189_00395	COG1959	2 iron, 2 sulfur cluster binding
AS189_00400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS189_00400	COG1017	nitric oxide dioxygenase activity
AS189_00430	COG2186	Transcriptional regulator
AS189_00445	COG0444	Belongs to the ABC transporter superfamily
AS189_00450	COG4608	Belongs to the ABC transporter superfamily
AS189_00455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AS189_00460	COG1940	carbohydrate kinase activity
AS189_00465	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AS189_00475	COG1511	domain protein
AS189_00480	COG2062	phosphohistidine phosphatase, SixA
AS189_00495	COG1846	Transcriptional regulator
AS189_00510	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AS189_00570	COG0745	RESPONSE REGULATOR receiver
AS189_00605	COG0395	ABC-type sugar transport system, permease component
AS189_00610	COG1175	transmembrane transport
AS189_00635	COG1201	RNA secondary structure unwinding
AS189_00640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AS189_00660	COG0564	pseudouridine synthase activity
AS189_00675	COG1595	DNA-templated transcription, initiation
AS189_00705	COG1302	Protein conserved in bacteria
AS189_00715	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AS189_00775	COG0343	queuine tRNA-ribosyltransferase activity
AS189_00800	COG0604	alcohol dehydrogenase
AS189_00815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AS189_00825	COG0583	DNA-binding transcription factor activity
AS189_00830	COG0477	Major facilitator Superfamily
AS189_00845	COG3226	Transcriptional regulator
AS189_00855	COG1012	belongs to the aldehyde dehydrogenase family
AS189_00875	COG1802	Transcriptional regulator
AS189_00880	COG1012	belongs to the aldehyde dehydrogenase family
AS189_00890	COG3971	2-oxopent-4-enoate hydratase activity
AS189_00920	COG1028	Short-chain dehydrogenase reductase Sdr
AS189_00940	COG2224	Isocitrate lyase
AS189_00955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS189_00960	COG3833	ABC-type maltose transport systems, permease component
AS189_00965	COG1175	transmembrane transport
AS189_00990	COG0673	inositol 2-dehydrogenase activity
AS189_00995	COG0673	inositol 2-dehydrogenase activity
AS189_01010	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AS189_01025	COG1132	(ABC) transporter
AS189_01060	COG3833	ABC-type maltose transport systems, permease component
AS189_01075	COG1609	Transcriptional regulator
AS189_01100	COG0488	(ABC) transporter
AS189_01115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AS189_01125	COG0785	Cytochrome C biogenesis protein
AS189_01135	COG0406	alpha-ribazole phosphatase activity
AS189_01140	COG2353	YceI-like domain
AS189_01155	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AS189_01165	COG0560	Phosphoserine phosphatase
AS189_01175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AS189_01180	COG3458	cephalosporin-C deacetylase activity
AS189_01185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS189_01190	COG4806	L-rhamnose isomerase
AS189_01190	COG1070	Carbohydrate kinase
AS189_01195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AS189_01220	COG0842	Transport permease protein
AS189_01220	COG1131	(ABC) transporter
AS189_01220	COG1716	ATPase activity
AS189_01225	COG0515	serine threonine protein kinase
AS189_01230	COG0123	including yeast histone deacetylase and acetoin utilization protein
AS189_01235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS189_01240	COG0569	domain protein
AS189_01245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AS189_01250	COG1595	DNA-templated transcription, initiation
AS189_01255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AS189_01265	COG1082	Xylose isomerase domain protein TIM barrel
AS189_01270	COG0248	Ppx GppA phosphatase
AS189_01275	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AS189_01280	COG1754	DNA topoisomerase type I activity
AS189_01280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AS189_01285	COG2890	protein-(glutamine-N5) methyltransferase activity
AS189_01300	COG1205	dead DEAH box helicase
AS189_01300	COG1111	helicase
AS189_01360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS189_01395	COG1408	metallophosphoesterase
AS189_01405	COG2824	Alkylphosphonate utilization operon protein PhnA
AS189_01420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AS189_01425	COG0151	Belongs to the GarS family
AS189_01460	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AS189_01475	COG0542	response to heat
AS189_01480	COG1063	alcohol dehydrogenase
AS189_01490	COG2226	methyltransferase
AS189_01520	COG4585	Histidine kinase
AS189_01525	COG2197	response regulator
AS189_01545	COG3304	Inner membrane component domain
AS189_01565	COG0475	glutathione-regulated potassium exporter activity
AS189_01565	COG0569	domain protein
AS189_01575	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AS189_01585	COG1140	nitrate reductase beta subunit
AS189_01605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS189_01610	COG0789	Transcriptional regulator
AS189_01615	COG0484	heat shock protein binding
AS189_01625	COG0443	Heat shock 70 kDa protein
AS189_01640	COG2132	Multicopper oxidase
AS189_01645	COG1280	lysine exporter protein (LysE YggA)
AS189_01670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS189_01720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AS189_01725	COG1609	Transcriptional regulator
AS189_01730	COG0039	L-malate dehydrogenase activity
AS189_01740	COG0395	ABC-type sugar transport system, permease component
AS189_01745	COG1175	transmembrane transport
AS189_01765	COG4721	ABC-type cobalt transport system, permease component
AS189_01775	COG1320	monovalent cation:proton antiporter activity
AS189_01800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AS189_01800	COG2111	Na H antiporter
AS189_01810	COG0717	Belongs to the dCTP deaminase family
AS189_01815	COG0569	domain protein
AS189_01820	COG0475	glutathione-regulated potassium exporter activity
AS189_01855	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AS189_01865	COG0433	COG0433 Predicted ATPase
AS189_01885	COG0776	regulation of translation
AS189_01890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AS189_01895	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AS189_01900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AS189_01910	COG1132	(ABC) transporter
AS189_01920	COG2130	NADP-dependent
AS189_01930	COG2764	glyoxalase bleomycin resistance protein dioxygenase
AS189_01945	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS189_01950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS189_01970	COG0435	Glutathione S-transferase
AS189_01975	COG0517	IMP dehydrogenase activity
AS189_01975	COG1125	glycine betaine transport
AS189_01980	COG1174	glycine betaine transport
AS189_02090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS189_02095	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS189_02100	COG0022	dehydrogenase e1 component
AS189_02110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AS189_02115	COG1950	PFAM Membrane protein of
AS189_02130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AS189_02135	COG1607	acyl-coa hydrolase
AS189_02150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AS189_02170	COG0028	Belongs to the TPP enzyme family
AS189_02175	COG0246	Mannitol dehydrogenase
AS189_02180	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS189_02180	COG2213	PTS system mannitol-specific
AS189_02190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AS189_02195	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS189_02195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AS189_02200	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AS189_02210	COG1937	Protein conserved in bacteria
AS189_02250	COG4821	SIS domain
AS189_02290	COG0305	Participates in initiation and elongation during chromosome replication
AS189_02300	COG0359	binds to the 23S rRNA
AS189_02305	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AS189_02315	COG0360	Binds together with S18 to 16S ribosomal RNA
AS189_02405	COG1716	ATPase activity
AS189_02410	COG1716	ATPase activity
AS189_02425	COG0768	penicillin binding
AS189_02445	COG3764	Sortase (surface protein transpeptidase)
AS189_02470	COG0705	Rhomboid family
AS189_02500	COG3266	domain, Protein
AS189_02505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AS189_02510	COG0187	DNA topoisomerase II activity
AS189_02515	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AS189_02520	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AS189_02525	COG0592	DNA-directed DNA polymerase activity
AS189_02530	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AS189_02535	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AS189_02540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AS189_02545	COG0706	membrane insertase activity
AS189_02555	COG0357	Ribosomal RNA small subunit methyltransferase G
AS189_02560	COG1192	Involved in chromosome partitioning
AS189_02575	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AS189_02605	COG3118	belongs to the thioredoxin family
AS189_02610	COG0492	ferredoxin-NADP+ reductase activity
AS189_02630	COG0617	tRNA 3'-terminal CCA addition
AS189_02635	COG0406	alpha-ribazole phosphatase activity
AS189_02665	COG3850	Histidine kinase
AS189_02670	COG2197	response regulator
AS189_02690	COG2197	response regulator
AS189_02700	COG0488	(ABC) transporter
AS189_02705	COG0738	Major facilitator superfamily
AS189_02725	COG4585	Histidine kinase
AS189_02730	COG2197	response regulator
AS189_02735	COG1362	aminopeptidase activity
AS189_02790	COG1358	cellular component organization or biogenesis
AS189_02815	COG3853	Toxic anion resistance protein (TelA)
AS189_02850	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AS189_02865	COG0247	lactate metabolic process
AS189_02870	COG1139	Iron-sulfur cluster binding protein
AS189_02875	COG1556	Lactate utilization protein
AS189_02885	COG1063	alcohol dehydrogenase
AS189_02935	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AS189_02970	COG2197	response regulator
AS189_02985	COG1609	Transcriptional regulator
AS189_03005	COG1929	Belongs to the glycerate kinase type-1 family
AS189_03010	COG2233	PERMEase
AS189_03035	COG3104	oligopeptide transport
AS189_03050	COG1597	lipid kinase activity
AS189_03060	COG0561	phosphatase activity
AS189_03120	COG2205	protein histidine kinase activity
AS189_03125	COG0745	RESPONSE REGULATOR receiver
AS189_03135	COG0037	tRNA processing
AS189_03145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AS189_03150	COG0302	gtp cyclohydrolase
AS189_03160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AS189_03190	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AS189_03195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS189_03205	COG1957	nucleoside hydrolase
AS189_03210	COG1609	Transcriptional regulator
AS189_03225	COG0542	response to heat
AS189_03230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AS189_03235	COG2376	Dihydroxyacetone kinase
AS189_03240	COG1461	Dihydroxyacetone kinase
AS189_03245	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AS189_03245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS189_03245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AS189_03250	COG1194	a g-specific adenine glycosylase
AS189_03265	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AS189_03285	COG0477	Major facilitator Superfamily
AS189_03290	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AS189_03305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AS189_03310	COG0306	phosphate transporter
AS189_03330	COG1335	isochorismatase
AS189_03335	COG0351	phosphomethylpyrimidine kinase
AS189_03345	COG4221	oxidoreductase activity
AS189_03350	COG0477	Major facilitator Superfamily
AS189_03355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS189_03360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AS189_03395	COG2733	membrane
AS189_03400	COG0584	glycerophosphoryl diester phosphodiesterase
AS189_03405	COG3387	PFAM Glycoside hydrolase 15-related
AS189_03465	COG0010	Belongs to the arginase family
AS189_03485	COG2252	PERMEase
AS189_03490	COG2372	response to copper ion
AS189_03515	COG1388	LysM domain
AS189_03515	COG3103	Sh3 type 3 domain protein
AS189_03515	COG0791	NLP P60 protein
AS189_03600	COG1609	Transcriptional regulator
AS189_03620	COG4176	ABC-type proline glycine betaine transport system permease component
AS189_03630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AS189_03635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AS189_03640	COG1435	thymidine kinase activity
AS189_03655	COG2801	Transposase and inactivated derivatives
AS189_03695	COG0191	fructose-bisphosphate aldolase activity
AS189_03720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AS189_03725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS189_03735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS189_03745	COG1116	anion transmembrane transporter activity
AS189_03750	COG1832	CoA-binding protein
AS189_03765	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AS189_03780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AS189_03785	COG0047	phosphoribosylformylglycinamidine synthase activity
AS189_03790	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AS189_03830	COG4555	ABC transporter
AS189_03840	COG0129	dihydroxy-acid dehydratase activity
AS189_03850	COG0069	glutamate synthase activity
AS189_03855	COG0028	Belongs to the TPP enzyme family
AS189_03860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AS189_03880	COG0386	Belongs to the glutathione peroxidase family
AS189_03900	COG1309	transcriptional regulator
AS189_03920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AS189_03930	COG1473	amidohydrolase
AS189_03950	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AS189_03955	COG4804	nuclease activity
AS189_03980	COG2801	Transposase and inactivated derivatives
AS189_04020	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AS189_04080	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AS189_04090	COG2259	Doxx family
AS189_04100	COG2365	Tyrosine phosphatase family
AS189_04120	COG0653	protein targeting
AS189_04135	COG1501	Belongs to the glycosyl hydrolase 31 family
AS189_04145	COG1609	Transcriptional regulator
AS189_04150	COG0395	ABC-type sugar transport system, permease component
AS189_04155	COG4209	transmembrane transport
AS189_04165	COG1472	Belongs to the glycosyl hydrolase 3 family
AS189_04170	COG2801	Transposase and inactivated derivatives
AS189_04185	COG0488	(ABC) transporter
AS189_04215	COG0857	belongs to the CobB CobQ family
AS189_04215	COG0280	phosphate acetyltransferase
AS189_04220	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AS189_04225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS189_04240	COG1024	Enoyl-CoA hydratase
AS189_04245	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS189_04250	COG1012	belongs to the aldehyde dehydrogenase family
AS189_04250	COG2030	dehydratase
AS189_04270	COG2050	protein possibly involved in aromatic compounds catabolism
AS189_04275	COG3396	Phenylacetate-CoA oxygenase
AS189_04280	COG3460	Phenylacetate-CoA oxygenase
AS189_04285	COG3396	Phenylacetate-CoA oxygenase
AS189_04290	COG2151	metal-sulfur cluster biosynthetic enzyme
AS189_04295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS189_04310	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AS189_04325	COG0022	dehydrogenase e1 component
AS189_04330	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS189_04350	COG4948	Mandelate Racemase Muconate Lactonizing
AS189_04355	COG0686	Belongs to the AlaDH PNT family
AS189_04365	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AS189_04380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS189_04385	COG1169	isochorismate synthase
AS189_04390	COG2226	methyltransferase
AS189_04420	COG2860	membrane
AS189_04445	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS189_04450	COG0175	sulfate reduction
AS189_04505	COG0657	acetylesterase activity
AS189_04505	COG2755	lipolytic protein G-D-S-L family
AS189_04525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS189_04525	COG1116	anion transmembrane transporter activity
AS189_04530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS189_04560	COG1012	belongs to the aldehyde dehydrogenase family
AS189_04585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AS189_04610	COG0531	amino acid
AS189_04630	COG0753	catalase activity
AS189_04645	COG0406	alpha-ribazole phosphatase activity
AS189_04650	COG4585	Histidine kinase
AS189_04655	COG2197	response regulator
AS189_04670	COG1666	GTP binding
AS189_04705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS189_04740	COG3655	Transcriptional regulator
AS189_04745	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AS189_04750	COG0583	DNA-binding transcription factor activity
AS189_04755	COG1012	belongs to the aldehyde dehydrogenase family
AS189_04770	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AS189_04770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AS189_04785	COG3583	domain protein
AS189_04790	COG0402	S-adenosylhomocysteine deaminase activity
AS189_04800	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AS189_04810	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AS189_04825	COG0477	Major facilitator Superfamily
AS189_04870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS189_04890	COG2301	Belongs to the HpcH HpaI aldolase family
AS189_04920	COG2030	dehydratase
AS189_04930	COG2223	nitrite transmembrane transporter activity
AS189_04935	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AS189_04955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AS189_05005	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AS189_05025	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AS189_05030	COG0456	acetyltransferase
AS189_05035	COG0745	RESPONSE REGULATOR receiver
AS189_05105	COG2197	response regulator
AS189_05110	COG0436	Aminotransferase
AS189_05120	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AS189_05125	COG0250	Participates in transcription elongation, termination and antitermination
AS189_05130	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AS189_05135	COG0081	regulation of translation
AS189_05150	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AS189_05155	COG0222	ribosome binding
AS189_05165	COG0183	Belongs to the thiolase family
AS189_05170	COG0085	RNA polymerase activity
AS189_05175	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AS189_05180	COG1752	Esterase of the alpha-beta hydrolase superfamily
AS189_05185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AS189_05190	COG0049	tRNA binding
AS189_05195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AS189_05200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AS189_05230	COG0051	transcription antitermination factor activity, RNA binding
AS189_05235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AS189_05240	COG0088	Forms part of the polypeptide exit tunnel
AS189_05245	COG0089	rRNA binding
AS189_05250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AS189_05255	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AS189_05260	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AS189_05265	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AS189_05270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AS189_05275	COG0255	Belongs to the universal ribosomal protein uL29 family
AS189_05280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AS189_05285	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AS189_05290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AS189_05295	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AS189_05300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AS189_05305	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AS189_05310	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AS189_05315	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AS189_05320	COG1841	ribosomal large subunit assembly
AS189_05325	COG0200	Binds to the 23S rRNA
AS189_05335	COG0563	adenylate kinase activity
AS189_05350	COG1175	transmembrane transport
AS189_05360	COG1653	transport
AS189_05370	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AS189_05375	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AS189_05380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AS189_05385	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AS189_05390	COG0202	RNA polymerase activity
AS189_05395	COG0203	ribosomal protein L17
AS189_05400	COG0101	tRNA pseudouridine synthase activity
AS189_05405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AS189_05410	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AS189_05415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AS189_05420	COG1970	mechanosensitive ion channel activity
AS189_05430	COG1072	(Pantothenic acid kinase))
AS189_05435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AS189_05440	COG0736	holo-[acyl-carrier-protein] synthase activity
AS189_05445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AS189_05445	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AS189_05455	COG0667	Aldo Keto reductase
AS189_05470	COG0366	Alpha amylase catalytic
AS189_05475	COG0395	ABC-type sugar transport system, permease component
AS189_05480	COG1175	transmembrane transport
AS189_05495	COG1940	carbohydrate kinase activity
AS189_05510	COG0438	transferase activity, transferring glycosyl groups
AS189_05515	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AS189_05520	COG0802	atpase or kinase
AS189_05530	COG0456	acetyltransferase
AS189_05535	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AS189_05545	COG5002	protein histidine kinase activity
AS189_05550	COG0745	RESPONSE REGULATOR receiver
AS189_05590	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AS189_05595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AS189_05640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AS189_05645	COG0459	protein refolding
AS189_05675	COG0516	GMP reductase activity
AS189_05695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AS189_05695	COG0519	Catalyzes the synthesis of GMP from XMP
AS189_05720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AS189_05725	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS189_05750	COG1695	Transcriptional regulator
AS189_05755	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AS189_05795	COG2017	converts alpha-aldose to the beta-anomer
AS189_05805	COG1172	Belongs to the binding-protein-dependent transport system permease family
AS189_05810	COG1172	Belongs to the binding-protein-dependent transport system permease family
AS189_05820	COG1879	ABC-type sugar transport system periplasmic component
AS189_05835	COG2160	L-arabinose isomerase activity
AS189_05840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS189_05850	COG1175	transmembrane transport
AS189_05860	COG4948	Mandelate Racemase Muconate Lactonizing
AS189_05865	COG3386	PFAM SMP-30 Gluconolaconase
AS189_05890	COG2017	converts alpha-aldose to the beta-anomer
AS189_05895	COG0395	ABC-type sugar transport system, permease component
AS189_05900	COG1175	transmembrane transport
AS189_05935	COG0412	Dienelactone hydrolase
AS189_05940	COG0488	(ABC) transporter
AS189_05965	COG1131	(ABC) transporter
AS189_05970	COG1309	transcriptional regulator
AS189_05985	COG0039	L-malate dehydrogenase activity
AS189_06000	COG0778	Nitroreductase
AS189_06005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AS189_06025	COG2971	BadF BadG BcrA BcrD
AS189_06030	COG1609	Transcriptional regulator
AS189_06050	COG2326	polyphosphate kinase activity
AS189_06055	COG1722	exodeoxyribonuclease VII activity
AS189_06060	COG1570	exodeoxyribonuclease VII activity
AS189_06070	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AS189_06075	COG1322	Protein conserved in bacteria
AS189_06080	COG0012	GTP binding
AS189_06135	COG0110	maltose O-acetyltransferase activity
AS189_06155	COG2318	DinB family
AS189_06160	COG0747	negative chemotaxis
AS189_06170	COG0747	negative chemotaxis
AS189_06175	COG0601	transmembrane transport
AS189_06180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS189_06185	COG4172	Belongs to the ABC transporter superfamily
AS189_06190	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS189_06225	COG3226	Transcriptional regulator
AS189_06240	COG2171	N-acyltransferase activity
AS189_06250	COG5343	regulation of RNA biosynthetic process
AS189_06265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS189_06270	COG0765	amino acid transport
AS189_06275	COG0765	amino acid transport
AS189_06280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS189_06285	COG1126	abc transporter atp-binding protein
AS189_06300	COG0519	Catalyzes the synthesis of GMP from XMP
AS189_06315	COG1595	DNA-templated transcription, initiation
AS189_06350	COG2239	Acts as a magnesium transporter
AS189_06370	COG0006	proline dipeptidase activity
AS189_06375	COG0613	PHP domain protein
AS189_06385	COG0513	Belongs to the DEAD box helicase family
AS189_06400	COG0477	Major facilitator Superfamily
AS189_06405	COG2814	Major facilitator Superfamily
AS189_06420	COG1113	amino acid transport
AS189_06425	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AS189_06425	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AS189_06430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AS189_06435	COG0509	glycine decarboxylation via glycine cleavage system
AS189_06440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AS189_06450	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AS189_06455	COG1620	l-lactate permease
AS189_06460	COG2186	Transcriptional regulator
AS189_06515	COG2072	flavoprotein involved in K transport
AS189_06520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS189_06540	COG0352	thiamine-phosphate diphosphorylase activity
AS189_06545	COG2022	thiamine diphosphate biosynthetic process
AS189_06545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS189_06555	COG2022	thiamine diphosphate biosynthetic process
AS189_06590	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AS189_06595	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AS189_06600	COG1233	COG1233 Phytoene dehydrogenase and related
AS189_06615	COG0181	hydroxymethylbilane synthase activity
AS189_06630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AS189_06640	COG1126	abc transporter atp-binding protein
AS189_06645	COG0765	amino acid transport
AS189_06650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS189_06670	COG0210	DNA helicase
AS189_06705	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AS189_06710	COG1615	UPF0182 protein
AS189_06720	COG0471	metal ion transport
AS189_06720	COG0490	domain, Protein
AS189_06730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AS189_06740	COG0628	permease
AS189_06750	COG1024	Enoyl-CoA hydratase
AS189_06755	COG0183	Belongs to the thiolase family
AS189_06760	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS189_06760	COG1024	Enoyl-CoA hydratase
AS189_06765	COG1024	Enoyl-CoA hydratase
AS189_06770	COG0318	PFAM AMP-dependent synthetase and ligase
AS189_06775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AS189_06785	COG1846	Transcriptional regulator
AS189_06795	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AS189_06810	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AS189_06820	COG1024	Enoyl-CoA hydratase
AS189_06845	COG3585	molybdate ion transport
AS189_06855	COG0667	Aldo Keto reductase
AS189_06870	COG1842	Phage shock protein A
AS189_06880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS189_06895	COG2086	electron transfer activity
AS189_06900	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AS189_06915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AS189_06920	COG0484	heat shock protein binding
AS189_06935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AS189_06940	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AS189_06950	COG0302	gtp cyclohydrolase
AS189_06970	COG0482	sulfurtransferase activity
AS189_06985	COG0601	transmembrane transport
AS189_06990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS189_06995	COG4172	Belongs to the ABC transporter superfamily
AS189_07020	COG0714	Associated with various cellular activities
AS189_07045	COG0745	RESPONSE REGULATOR receiver
AS189_07050	COG5000	phosphorelay sensor kinase activity
AS189_07050	COG5002	protein histidine kinase activity
AS189_07055	COG5401	PFAM Sporulation and spore germination
AS189_07060	COG1040	competence protein
AS189_07065	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AS189_07070	COG3214	Protein conserved in bacteria
AS189_07075	COG0653	protein targeting
AS189_07110	COG2902	Dehydrogenase
AS189_07130	COG1674	ftsk spoiiie
AS189_07140	COG1216	Glycosyl transferase, family 2
AS189_07160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AS189_07160	COG2755	lipolytic protein G-D-S-L family
AS189_07185	COG0673	inositol 2-dehydrogenase activity
AS189_07190	COG0297	glycogen (starch) synthase activity
AS189_07240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AS189_07295	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AS189_07300	COG2720	vancomycin resistance protein
AS189_07310	COG2177	Part of the ABC transporter FtsEX involved in
AS189_07320	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AS189_07330	COG1472	Belongs to the glycosyl hydrolase 3 family
AS189_07385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS189_07395	COG1321	iron dependent repressor
AS189_07415	COG0483	inositol monophosphate 1-phosphatase activity
AS189_07425	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AS189_07460	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS189_07460	COG0567	Dehydrogenase, E1 component
AS189_07475	COG1609	Transcriptional regulator
AS189_07490	COG0747	negative chemotaxis
AS189_07520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AS189_07525	COG1609	Transcriptional regulator
AS189_07530	COG1904	glucuronate isomerase
AS189_07535	COG0246	Mannitol dehydrogenase
AS189_07545	COG4948	Mandelate Racemase Muconate Lactonizing
AS189_07560	COG3265	gluconokinase activity
AS189_07575	COG1253	flavin adenine dinucleotide binding
AS189_07585	COG0803	Belongs to the bacterial solute-binding protein 9 family
AS189_07590	COG3842	ATPase activity
AS189_07595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AS189_07620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS189_07630	COG1064	alcohol dehydrogenase
AS189_07635	COG0537	adenosine 5'-monophosphoramidase activity
AS189_07645	COG1643	Atp-dependent helicase
AS189_07660	COG0697	spore germination
AS189_07680	COG2723	6-phospho-beta-galactosidase activity
AS189_07695	COG0018	arginyl-trna synthetase
AS189_07700	COG0019	diaminopimelate decarboxylase activity
AS189_07705	COG0460	homoserine dehydrogenase
AS189_07710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AS189_07725	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AS189_07730	COG2890	protein-(glutamine-N5) methyltransferase activity
AS189_07760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AS189_07775	COG0356	it plays a direct role in the translocation of protons across the membrane
AS189_07780	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AS189_07785	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AS189_07790	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AS189_07795	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AS189_07800	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AS189_07805	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AS189_07810	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AS189_07820	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AS189_07825	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AS189_07840	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AS189_07850	COG0628	permease
AS189_07860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS189_07875	COG0363	glucosamine-6-phosphate deaminase activity
AS189_07890	COG1335	isochorismatase
AS189_07895	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AS189_07900	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AS189_07910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AS189_07925	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AS189_07930	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AS189_07935	COG0586	Pfam SNARE associated Golgi protein
AS189_07955	COG2149	membrane
AS189_07965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AS189_07975	COG0420	3'-5' exonuclease activity
AS189_07980	COG0419	ATPase involved in DNA repair
AS189_07995	COG1113	amino acid transport
AS189_08005	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AS189_08010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AS189_08020	COG1104	cysteine desulfurase activity
AS189_08040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS189_08050	COG1403	HNH endonuclease
AS189_08055	COG1846	Transcriptional regulator
AS189_08060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS189_08065	COG2814	Major facilitator Superfamily
AS189_08075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS189_08080	COG0579	oxidoreductase
AS189_08085	COG0747	negative chemotaxis
AS189_08110	COG0129	dihydroxy-acid dehydratase activity
AS189_08120	COG0440	acetolactate synthase activity
AS189_08125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AS189_08155	COG0577	efflux transmembrane transporter activity
AS189_08155	COG1136	(ABC) transporter
AS189_08170	COG2197	response regulator
AS189_08175	COG4585	Histidine kinase
AS189_08180	COG0702	epimerase
AS189_08220	COG0415	Belongs to the DNA photolyase family
AS189_08225	COG0473	3-isopropylmalate dehydrogenase activity
AS189_08230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AS189_08255	COG2197	response regulator
AS189_08260	COG1113	amino acid transport
AS189_08290	COG2072	flavoprotein involved in K transport
AS189_08295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AS189_08325	COG2197	response regulator
AS189_08345	COG1414	Transcriptional regulator
AS189_08350	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AS189_08355	COG0066	3-isopropylmalate dehydratase activity
AS189_08365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AS189_08375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AS189_08380	COG1181	Belongs to the D-alanine--D-alanine ligase family
AS189_08400	COG2813	Specifically methylates the guanine in position
AS189_08405	COG1316	TRANSCRIPTIONal
AS189_08420	COG2267	carboxylic ester hydrolase activity
AS189_08425	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AS189_08445	COG0640	Transcriptional regulator
AS189_08450	COG0798	PFAM Bile acid sodium symporter
AS189_08495	COG0742	ribosomal rna small subunit methyltransferase
AS189_08500	COG2268	Band 7 protein
AS189_08510	COG0673	inositol 2-dehydrogenase activity
AS189_08530	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AS189_08545	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AS189_08550	COG0571	ribonuclease III activity
AS189_08555	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AS189_08570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS189_08575	COG0318	PFAM AMP-dependent synthetase and ligase
AS189_08580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS189_08605	COG1126	abc transporter atp-binding protein
AS189_08640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS189_08650	COG0477	Major facilitator Superfamily
AS189_08660	COG2197	response regulator
AS189_08675	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AS189_08695	COG2514	catechol 2,3-dioxygenase activity
AS189_08705	COG0228	four-way junction DNA binding
AS189_08710	COG1837	Belongs to the UPF0109 family
AS189_08715	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AS189_08720	COG0336	Belongs to the RNA methyltransferase TrmD family
AS189_08725	COG0335	large ribosomal subunit rRNA binding
AS189_08730	COG0681	Belongs to the peptidase S26 family
AS189_08740	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AS189_08750	COG1733	regulation of RNA biosynthetic process
AS189_08755	COG2910	NAD(P)H-binding
AS189_08760	COG0792	nuclease activity
AS189_08780	COG1316	TRANSCRIPTIONal
AS189_08800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AS189_08805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS189_08820	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AS189_08845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AS189_08850	COG1414	Transcriptional regulator
AS189_08855	COG0477	Major facilitator Superfamily
AS189_08865	COG2084	Dehydrogenase
AS189_08870	COG1028	Short-chain dehydrogenase reductase Sdr
AS189_08875	COG1063	alcohol dehydrogenase
AS189_08880	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AS189_08885	COG1045	serine acetyltransferase
AS189_08895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS189_08900	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AS189_08910	COG3022	response to hydroperoxide
AS189_08925	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AS189_08935	COG0477	Major facilitator Superfamily
AS189_08940	COG0242	peptide deformylase activity
AS189_08985	COG2890	protein-(glutamine-N5) methyltransferase activity
AS189_09000	COG2072	flavoprotein involved in K transport
AS189_09025	COG2197	response regulator
AS189_09075	COG1846	Transcriptional regulator
AS189_09080	COG3142	Participates in the control of copper homeostasis
AS189_09095	COG0747	negative chemotaxis
AS189_09120	COG3540	Alkaline phosphatase
AS189_09160	COG1414	Transcriptional regulator
AS189_09165	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AS189_09175	COG0183	Belongs to the thiolase family
AS189_09185	COG0583	DNA-binding transcription factor activity
AS189_09200	COG3485	protocatechuate 3,4-dioxygenase
AS189_09205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS189_09215	COG2909	trisaccharide binding
AS189_09220	COG2814	Major facilitator Superfamily
AS189_09235	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AS189_09240	COG4638	Rieske (2fe-2S)
AS189_09265	COG5002	protein histidine kinase activity
AS189_09275	COG2132	Multicopper oxidase
AS189_09275	COG2132	Multicopper oxidase
AS189_09315	COG3550	peptidyl-serine autophosphorylation
AS189_09465	COG1131	(ABC) transporter
AS189_09470	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AS189_09475	COG3547	Transposase (IS116 IS110 IS902 family)
AS189_09485	COG2205	protein histidine kinase activity
AS189_09490	COG0745	RESPONSE REGULATOR receiver
AS189_09495	COG0671	phosphoesterase, PA-phosphatase related
AS189_09505	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AS189_09520	COG0745	RESPONSE REGULATOR receiver
AS189_09525	COG0642	Histidine kinase
AS189_09550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS189_09720	COG0629	single-stranded DNA binding
AS189_09755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AS189_09765	COG0587	DNA-directed DNA polymerase activity
AS189_09805	COG0270	DNA (cytosine-5-)-methyltransferase activity
AS189_09830	COG1946	Acyl-CoA thioesterase
AS189_09880	COG0698	ribose 5-phosphate isomerase
AS189_09900	COG0544	peptidyl-prolyl cis-trans isomerase activity
AS189_09905	COG0740	serine-type endopeptidase activity
AS189_09910	COG0740	serine-type endopeptidase activity
AS189_09915	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AS189_09920	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AS189_09925	COG0438	transferase activity, transferring glycosyl groups
AS189_09925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AS189_09930	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AS189_09940	COG0525	valine-tRNA ligase activity
AS189_09960	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AS189_09965	COG0285	dihydrofolate synthase activity
AS189_09975	COG0105	UTP biosynthetic process
AS189_09985	COG1530	ribonuclease E activity
AS189_09990	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AS189_09990	COG0352	thiamine-phosphate diphosphorylase activity
AS189_09990	COG0351	phosphomethylpyrimidine kinase
AS189_09995	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AS189_10000	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AS189_10005	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AS189_10010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AS189_10015	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AS189_10025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AS189_10035	COG0799	negative regulation of ribosome biogenesis
AS189_10055	COG3012	SEC-C Motif Domain Protein
AS189_10060	COG2813	Specifically methylates the guanine in position
AS189_10065	COG1940	carbohydrate kinase activity
AS189_10075	COG0714	Associated with various cellular activities
AS189_10115	COG1012	belongs to the aldehyde dehydrogenase family
AS189_10140	COG1780	Probably involved in ribonucleotide reductase function
AS189_10145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS189_10150	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS189_10155	COG4682	membrane
AS189_10180	COG0318	PFAM AMP-dependent synthetase and ligase
AS189_10215	COG2135	peptidase activity
AS189_10225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS189_10225	COG0456	acetyltransferase
AS189_10245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AS189_10260	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AS189_10270	COG0456	acetyltransferase
AS189_10275	COG0339	signal peptide processing
AS189_10280	COG0367	asparagine synthase
AS189_10285	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AS189_10290	COG0217	transcriptional regulatory protein
AS189_10295	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AS189_10300	COG0632	four-way junction helicase activity
AS189_10315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AS189_10320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AS189_10325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AS189_10335	COG1196	nuclear chromosome segregation
AS189_10345	COG0124	histidyl-tRNA synthetase
AS189_10350	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AS189_10360	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AS189_10380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AS189_10395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AS189_10400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AS189_10410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AS189_10415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AS189_10420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AS189_10425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AS189_10435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AS189_10440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AS189_10450	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AS189_10455	COG0540	Belongs to the ATCase OTCase family
AS189_10460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AS189_10470	COG0505	Belongs to the CarA family
AS189_10475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AS189_10480	COG0284	orotidine-5'-phosphate decarboxylase activity
AS189_10485	COG0194	GDP metabolic process
AS189_10490	COG0194	GDP metabolic process
AS189_10495	COG1758	RNA polymerase activity
AS189_10505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AS189_10510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AS189_10525	COG0297	glycogen (starch) synthase activity
AS189_10535	COG0656	L-ascorbic acid biosynthetic process
AS189_10540	COG2390	Transcriptional regulator
AS189_10545	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AS189_10550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AS189_10555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AS189_10560	COG0495	leucyl-tRNA aminoacylation
AS189_10565	COG1307	EDD domain protein, DegV family
AS189_10585	COG0076	glutamate decarboxylase activity
AS189_10590	COG0268	Binds directly to 16S ribosomal RNA
AS189_10600	COG0481	GTPase activity
AS189_10605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AS189_10620	COG1420	regulation of RNA biosynthetic process
AS189_10625	COG0484	heat shock protein binding
AS189_10645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AS189_10655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AS189_10660	COG1316	TRANSCRIPTIONal
AS189_10665	COG3590	peptidase
AS189_10670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AS189_10675	COG1381	Involved in DNA repair and RecF pathway recombination
AS189_10680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AS189_10695	COG0167	dihydroorotate dehydrogenase activity
AS189_10700	COG0667	Aldo Keto reductase
AS189_10710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS189_10720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AS189_10725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AS189_10745	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AS189_10750	COG0723	plastoquinol--plastocyanin reductase activity
AS189_10755	COG2010	Cytochrome c
AS189_10760	COG1845	cytochrome c oxidase, subunit III
AS189_10765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AS189_10770	COG3142	Participates in the control of copper homeostasis
AS189_10800	COG2261	transglycosylase associated protein
AS189_10805	COG0318	PFAM AMP-dependent synthetase and ligase
AS189_10835	COG2050	protein possibly involved in aromatic compounds catabolism
AS189_10845	COG4552	Acetyltransferase involved in intracellular survival and related
AS189_10855	COG0539	negative regulation of cytoplasmic translation
AS189_10865	COG1739	Uncharacterized protein family UPF0029
AS189_10870	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS189_10870	COG0237	dephospho-CoA kinase activity
AS189_10885	COG0556	nucleotide-excision repair
AS189_10895	COG0456	acetyltransferase
AS189_10905	COG4106	trans-aconitate 2-methyltransferase activity
AS189_10940	COG1832	CoA-binding protein
AS189_10970	COG0322	excinuclease ABC activity
AS189_10985	COG1660	Displays ATPase and GTPase activities
AS189_10995	COG1481	regulation of sporulation
AS189_11005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AS189_11010	COG0126	phosphoglycerate kinase activity
AS189_11015	COG0149	triose-phosphate isomerase activity
AS189_11020	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AS189_11025	COG0363	glucosamine-6-phosphate deaminase activity
AS189_11040	COG0166	Belongs to the GPI family
AS189_11045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AS189_11055	COG0109	protoheme IX farnesyltransferase activity
AS189_11080	COG0640	Transcriptional regulator
AS189_11140	COG0396	ATPase activity
AS189_11145	COG2151	metal-sulfur cluster biosynthetic enzyme
AS189_11155	COG0318	PFAM AMP-dependent synthetase and ligase
AS189_11190	COG1122	ATPase activity
AS189_11195	COG1268	BioY protein
AS189_11225	COG1028	Short-chain dehydrogenase reductase Sdr
AS189_11230	COG1028	Short-chain dehydrogenase reductase Sdr
AS189_11235	COG0560	Phosphoserine phosphatase
AS189_11235	COG3830	Belongs to the UPF0237 family
AS189_11260	COG0254	rRNA binding
AS189_11265	COG0095	Lipoate-protein ligase
AS189_11275	COG2514	catechol 2,3-dioxygenase activity
AS189_11285	COG2855	membrane
AS189_11300	COG0297	glycogen (starch) synthase activity
AS189_11330	COG0183	Belongs to the thiolase family
AS189_11335	COG1028	Short-chain dehydrogenase reductase Sdr
AS189_11360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS189_11380	COG0667	Aldo Keto reductase
AS189_11385	COG1968	undecaprenyl-diphosphatase activity
AS189_11390	COG0215	cysteine-tRNA ligase activity
AS189_11400	COG0546	phosphoglycolate phosphatase activity
AS189_11405	COG0517	IMP dehydrogenase activity
AS189_11405	COG1994	Peptidase M50
AS189_11415	COG1222	aaa ATPase
AS189_11420	COG4122	O-methyltransferase activity
AS189_11435	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AS189_11440	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AS189_11445	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AS189_11470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS189_11475	COG0805	protein transport
AS189_11485	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AS189_11490	COG1216	Glycosyl transferase, family 2
AS189_11515	COG2364	Membrane
AS189_11525	COG0242	peptide deformylase activity
AS189_11600	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS189_11670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS189_11710	COG2217	Heavy metal translocating P-type atpase
AS189_11730	COG0300	oxidoreductase activity
AS189_11775	COG2197	response regulator
AS189_11780	COG4585	Histidine kinase
AS189_11835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AS189_11840	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS189_11875	COG0454	-acetyltransferase
AS189_11950	COG1725	Transcriptional regulator
AS189_11970	COG2264	protein methyltransferase activity
AS189_12005	COG1162	GTPase activity
AS189_12020	COG0673	inositol 2-dehydrogenase activity
AS189_12060	COG0009	L-threonylcarbamoyladenylate synthase
AS189_12065	COG0783	Belongs to the Dps family
AS189_12070	COG1028	Short-chain dehydrogenase reductase Sdr
AS189_12075	COG1643	Atp-dependent helicase
AS189_12095	COG2268	Band 7 protein
AS189_12155	COG0135	phosphoribosylanthranilate isomerase activity
AS189_12160	COG1940	carbohydrate kinase activity
AS189_12175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS189_12180	COG3119	arylsulfatase activity
AS189_12195	COG2814	Major facilitator Superfamily
AS189_12210	COG0833	amino acid
AS189_12215	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AS189_12220	COG0829	nickel cation binding
AS189_12225	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AS189_12230	COG0830	nickel cation binding
AS189_12235	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AS189_12240	COG0804	urea catabolic process
AS189_12245	COG0832	Belongs to the urease beta subunit family
AS189_12280	COG1902	pentaerythritol trinitrate reductase activity
AS189_12345	COG3795	YCII-related domain
AS189_12350	COG0183	Belongs to the thiolase family
AS189_12365	COG1960	acyl-CoA dehydrogenase activity
AS189_12370	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS189_12375	COG1024	Enoyl-CoA hydratase
AS189_12380	COG1960	acyl-CoA dehydrogenase activity
AS189_12385	COG0318	PFAM AMP-dependent synthetase and ligase
AS189_12390	COG1028	Short-chain dehydrogenase reductase Sdr
AS189_12400	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AS189_12415	COG1609	Transcriptional regulator
AS189_12420	COG1653	transport
AS189_12425	COG1175	transmembrane transport
AS189_12445	COG0673	inositol 2-dehydrogenase activity
AS189_12475	COG2814	Major facilitator Superfamily
AS189_12490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS189_12495	COG0387	Pfam Sodium calcium exchanger
AS189_12515	COG1854	S-ribosylhomocysteine lyase activity
AS189_12520	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AS189_12530	COG0019	diaminopimelate decarboxylase activity
AS189_12540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS189_12575	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AS189_12585	COG2354	Protein conserved in bacteria
AS189_12590	COG2267	carboxylic ester hydrolase activity
AS189_12595	COG1609	Transcriptional regulator
AS189_12605	COG4172	Belongs to the ABC transporter superfamily
AS189_12620	COG0601	transmembrane transport
AS189_12630	COG1940	carbohydrate kinase activity
AS189_12650	COG1132	(ABC) transporter
AS189_12655	COG1846	Transcriptional regulator
AS189_12660	COG1764	response to oxidative stress
AS189_12730	COG1064	alcohol dehydrogenase
AS189_12740	COG2133	pyrroloquinoline quinone binding
AS189_12765	COG0277	FAD linked oxidase domain protein
AS189_12765	COG0277	FAD linked oxidase domain protein
AS189_12790	COG1414	Transcriptional regulator
AS189_12800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AS189_12800	COG0574	Belongs to the PEP-utilizing enzyme family
AS189_12805	COG0574	Belongs to the PEP-utilizing enzyme family
AS189_12805	COG3848	Pyruvate phosphate dikinase
AS189_12810	COG1028	Short-chain dehydrogenase reductase Sdr
AS189_12835	COG0667	Aldo Keto reductase
AS189_12865	COG2159	amidohydrolase
AS189_12875	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AS189_12880	COG1414	Transcriptional regulator
AS189_12950	COG0589	response to stress
AS189_12965	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AS189_13005	COG2205	protein histidine kinase activity
AS189_13010	COG0745	RESPONSE REGULATOR receiver
AS189_13070	COG4974	Belongs to the 'phage' integrase family
AS189_13130	COG0783	Belongs to the Dps family
AS189_13150	COG2267	carboxylic ester hydrolase activity
AS189_13170	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AS189_13200	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AS189_13220	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AS189_13350	COG0857	belongs to the CobB CobQ family
AS189_13350	COG0280	phosphate acetyltransferase
AS189_13355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AS189_13355	COG0574	Belongs to the PEP-utilizing enzyme family
AS189_13405	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AS189_13450	COG1131	(ABC) transporter
AS189_13505	COG4152	abc transporter atp-binding protein
AS189_13545	COG0070	glutamate synthase
AS189_13545	COG0069	glutamate synthase activity
AS189_13545	COG0067	glutamate synthase
AS189_13550	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AS189_13555	COG0159	tryptophan synthase activity
AS189_13565	COG0134	indole-3-glycerol-phosphate synthase activity
AS189_13585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AS189_13595	COG0107	imidazoleglycerol-phosphate synthase activity
AS189_13600	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AS189_13605	COG0140	phosphoribosyl-ATP diphosphatase activity
AS189_13610	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AS189_13615	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AS189_13620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AS189_13620	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AS189_13640	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AS189_13650	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AS189_13655	COG0242	peptide deformylase activity
AS189_13725	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AS189_13740	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS189_13765	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AS189_13775	COG1024	Enoyl-CoA hydratase
AS189_13775	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS189_13790	COG0667	Aldo Keto reductase
AS189_13805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AS189_13810	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AS189_13820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AS189_13825	COG0531	amino acid
AS189_13830	COG0569	domain protein
AS189_13855	COG0756	dUTP diphosphatase activity
AS189_13905	COG4988	ABC transporter
AS189_13910	COG1294	oxidase, subunit
AS189_13915	COG1271	oxidase subunit
AS189_13940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AS189_13950	COG2223	nitrite transmembrane transporter activity
AS189_13960	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AS189_13965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AS189_13970	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS189_13990	COG0321	lipoyl(octanoyl) transferase activity
AS189_13995	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AS189_14040	COG2066	Belongs to the glutaminase family
AS189_14045	COG1126	abc transporter atp-binding protein
AS189_14050	COG0765	amino acid transport
AS189_14055	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AS189_14060	COG0174	glutamine synthetase
AS189_14065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AS189_14080	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AS189_14085	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AS189_14095	COG0587	DNA-directed DNA polymerase activity
AS189_14120	COG1799	cell septum assembly
AS189_14125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AS189_14135	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AS189_14145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AS189_14150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AS189_14160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AS189_14165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AS189_14175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AS189_14180	COG0768	penicillin binding
AS189_14190	COG0275	rRNA processing
AS189_14195	COG2001	Belongs to the MraZ family
AS189_14225	COG1388	LysM domain
AS189_14225	COG3942	CHAP domain
AS189_14230	COG2815	serine threonine protein kinase
AS189_14230	COG0515	serine threonine protein kinase
AS189_14235	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AS189_14255	COG1940	carbohydrate kinase activity
AS189_14330	COG2885	chlorophyll binding
AS189_14340	COG1222	aaa ATPase
AS189_14430	COG1716	ATPase activity
AS189_14435	COG0509	glycine decarboxylation via glycine cleavage system
AS189_14445	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AS189_14450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AS189_14470	COG1960	acyl-CoA dehydrogenase activity
AS189_14485	COG2357	RelA SpoT domain protein
AS189_14490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS189_14495	COG4106	trans-aconitate 2-methyltransferase activity
AS189_14505	COG1022	Amp-dependent synthetase and ligase
AS189_14510	COG1960	acyl-CoA dehydrogenase activity
AS189_14515	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS189_14515	COG0596	Alpha beta hydrolase
AS189_14530	COG2072	flavoprotein involved in K transport
AS189_14540	COG1160	GTP binding
AS189_14550	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AS189_14565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AS189_14570	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AS189_14590	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AS189_14610	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AS189_14630	COG0590	tRNA wobble adenosine to inosine editing
AS189_14655	COG0504	CTP synthase activity
AS189_14675	COG0647	UMP catabolic process
AS189_14715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AS189_14725	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AS189_14755	COG0165	Argininosuccinate lyase
AS189_14760	COG0137	argininosuccinate synthase activity
AS189_14765	COG1438	arginine binding
AS189_14770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AS189_14775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AS189_14780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AS189_14785	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AS189_14790	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AS189_14815	COG2326	polyphosphate kinase activity
AS189_14850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS189_14855	COG2267	carboxylic ester hydrolase activity
AS189_14870	COG0072	phenylalanine-tRNA ligase activity
AS189_14870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS189_14875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AS189_14900	COG0318	PFAM AMP-dependent synthetase and ligase
AS189_14925	COG2814	Major facilitator Superfamily
AS189_14930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS189_14935	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AS189_14940	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AS189_14945	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AS189_14965	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AS189_14970	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AS189_14975	COG0131	Imidazoleglycerol-phosphate dehydratase
AS189_14980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AS189_14990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AS189_15000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AS189_15010	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AS189_15015	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AS189_15020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AS189_15030	COG2137	regulation of response to DNA damage stimulus
AS189_15035	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AS189_15050	COG1396	sequence-specific DNA binding
AS189_15055	COG1546	Belongs to the CinA family
AS189_15055	COG1058	Belongs to the CinA family
AS189_15065	COG1674	ftsk spoiiie
AS189_15070	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AS189_15075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AS189_15080	COG0596	Alpha beta hydrolase
AS189_15090	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AS189_15100	COG0521	Mo-molybdopterin cofactor biosynthetic process
AS189_15130	COG0612	Peptidase, M16
AS189_15135	COG1185	polyribonucleotide nucleotidyltransferase activity
AS189_15140	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AS189_15165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AS189_15180	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AS189_15225	COG0442	prolyl-tRNA aminoacylation
AS189_15235	COG1131	(ABC) transporter
AS189_15255	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS189_15255	COG1902	pentaerythritol trinitrate reductase activity
AS189_15265	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AS189_15285	COG0750	zinc metalloprotease
AS189_15325	COG1960	acyl-CoA dehydrogenase activity
AS189_15335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AS189_15350	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS189_15355	COG0022	dehydrogenase e1 component
AS189_15365	COG1522	sequence-specific DNA binding
AS189_15380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS189_15390	COG3275	phosphorelay sensor kinase activity
AS189_15395	COG3279	Response regulator of the LytR AlgR family
AS189_15405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS189_15420	COG0233	cytoplasmic translational termination
AS189_15425	COG0528	UMP kinase activity
AS189_15430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AS189_15435	COG0052	Belongs to the universal ribosomal protein uS2 family
AS189_15445	COG1960	acyl-CoA dehydrogenase activity
AS189_15455	COG0297	glycogen (starch) synthase activity
AS189_15475	COG2814	Major facilitator Superfamily
AS189_15490	COG0358	DNA primase activity
AS189_15515	COG2239	Acts as a magnesium transporter
AS189_15520	COG3424	synthase
AS189_15530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS189_15545	COG0423	glycine-tRNA ligase activity
AS189_15555	COG1695	Transcriptional regulator
AS189_15575	COG2755	lipolytic protein G-D-S-L family
AS189_15590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AS189_15595	COG2873	o-acetylhomoserine
AS189_15600	COG2183	response to ionizing radiation
AS189_15615	COG0588	phosphoglycerate mutase activity
AS189_15625	COG2822	iron ion transport
AS189_15630	COG2837	iron assimilation
AS189_15640	COG3290	protein histidine kinase activity
AS189_15665	COG1940	carbohydrate kinase activity
AS189_15675	COG0366	Alpha amylase catalytic
AS189_15675	COG1470	cell adhesion involved in biofilm formation
AS189_15695	COG0346	lactoylglutathione lyase activity
AS189_15710	COG2318	DinB family
AS189_15795	COG0577	efflux transmembrane transporter activity
AS189_15800	COG1136	(ABC) transporter
AS189_15835	COG2826	transposase and inactivated derivatives, IS30 family
AS189_15845	COG0071	Belongs to the small heat shock protein (HSP20) family
AS189_15860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AS189_15880	COG0156	8-amino-7-oxononanoate synthase activity
AS189_15885	COG1063	alcohol dehydrogenase
AS189_15900	COG0673	inositol 2-dehydrogenase activity
AS189_15905	COG1609	Transcriptional regulator
AS189_15915	COG0395	ABC-type sugar transport system, permease component
AS189_15920	COG4209	transmembrane transport
AS189_15925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AS189_15930	COG0154	amidase activity
AS189_15935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AS189_15950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AS189_15960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AS189_15975	COG1674	ftsk spoiiie
AS189_16025	COG0714	Associated with various cellular activities
AS189_16070	COG1802	Transcriptional regulator
AS189_16075	COG2423	ornithine cyclodeaminase activity
AS189_16100	COG0006	proline dipeptidase activity
AS189_16105	COG3938	Belongs to the proline racemase family
AS189_16110	COG0410	ABC transporter
AS189_16125	COG0559	Belongs to the binding-protein-dependent transport system permease family
AS189_16150	COG1403	HNH endonuclease
AS189_16155	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AS189_16185	COG2409	Drug exporters of the RND superfamily
AS189_16215	COG0424	maF-like protein
AS189_16230	COG4770	biotin carboxylase activity
AS189_16270	COG0733	neurotransmitter:sodium symporter activity
AS189_16275	COG0477	Major facilitator Superfamily
AS189_16280	COG2223	nitrite transmembrane transporter activity
AS189_16285	COG0243	molybdopterin cofactor binding
AS189_16290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS189_16305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AS189_16315	COG2146	nitrite reductase [NAD(P)H] activity
AS189_16315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS189_16330	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AS189_16395	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AS189_16445	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AS189_16445	COG2755	lipolytic protein G-D-S-L family
AS189_16495	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AS189_16500	COG1088	dTDP-glucose 4,6-dehydratase activity
AS189_16565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AS189_16585	COG0193	aminoacyl-tRNA hydrolase activity
AS189_16590	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AS189_16605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AS189_16620	COG0488	(ABC) transporter
AS189_16625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AS189_16630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AS189_16640	COG0084	hydrolase, TatD family'
AS189_16645	COG0714	Associated with various cellular activities
AS189_16685	COG0681	Belongs to the peptidase S26 family
AS189_16785	COG1316	TRANSCRIPTIONal
AS189_16800	COG1494	fructose-1,6-bisphosphatase
AS189_16810	COG0288	reversible hydration of carbon dioxide
AS189_16815	COG0114	fumarate hydratase activity
AS189_16825	COG0477	Major facilitator Superfamily
AS189_16840	COG2851	Citrate transporter
AS189_16845	COG3290	protein histidine kinase activity
AS189_16850	COG4565	transcriptional regulatory protein
AS189_16865	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AS189_16875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AS189_16885	COG1331	Highly conserved protein containing a thioredoxin domain
AS189_16895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS189_16905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AS189_16915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AS189_16925	COG2017	converts alpha-aldose to the beta-anomer
AS189_16930	COG1349	DNA-binding transcription factor activity
AS189_16940	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AS189_16945	COG0861	Integral membrane protein TerC family
AS189_17000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AS189_17005	COG0586	Pfam SNARE associated Golgi protein
AS189_17040	COG1473	amidohydrolase
AS189_17040	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AS189_17050	COG2009	succinate dehydrogenase
AS189_17065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AS189_17085	COG0180	Tryptophanyl-tRNA synthetase
AS189_17115	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AS189_17120	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AS189_17130	COG0667	Aldo Keto reductase
AS189_17135	COG0531	amino acid
AS189_17200	COG2838	Isocitrate dehydrogenase
AS189_17215	COG0138	bifunctional purine biosynthesis protein purh
AS189_17220	COG1472	Belongs to the glycosyl hydrolase 3 family
AS189_17225	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AS189_17230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AS189_17235	COG0477	Major facilitator Superfamily
AS189_17260	COG1278	Cold shock
AS189_17265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AS189_17265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AS189_17295	COG0492	ferredoxin-NADP+ reductase activity
AS189_17380	COG3384	dioxygenase
AS189_17405	COG2084	Dehydrogenase
AS189_17425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AS189_17440	COG0659	secondary active sulfate transmembrane transporter activity
AS189_17450	COG0747	negative chemotaxis
AS189_17470	COG1940	carbohydrate kinase activity
AS189_17475	COG2115	Belongs to the xylose isomerase family
AS189_17480	COG1070	Carbohydrate kinase
AS189_17495	COG4214	carbohydrate transport
AS189_17500	COG1185	polyribonucleotide nucleotidyltransferase activity
AS189_17510	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AS189_17530	COG1309	transcriptional regulator
AS189_17535	COG0149	triose-phosphate isomerase activity
AS189_17540	COG2271	Major facilitator Superfamily
AS189_17545	COG1028	Short-chain dehydrogenase reductase Sdr
AS189_17550	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS189_17555	COG0698	ribose 5-phosphate isomerase
AS189_17560	COG2376	Dihydroxyacetone kinase
AS189_17580	COG0431	NADPH-dependent FMN reductase
AS189_17590	COG1027	Aspartate ammonia-lyase
AS189_17600	COG2186	Transcriptional regulator
AS189_17620	COG1090	epimerase
AS189_17625	COG1309	transcriptional regulator
AS189_17675	COG0326	Molecular chaperone. Has ATPase activity
AS189_17680	COG0028	Belongs to the TPP enzyme family
AS189_17705	COG1396	sequence-specific DNA binding
AS189_17720	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS189_17745	COG0656	L-ascorbic acid biosynthetic process
AS189_17750	COG2814	Major facilitator Superfamily
AS189_17765	COG0045	succinate-CoA ligase (ADP-forming) activity
AS189_17780	COG0483	inositol monophosphate 1-phosphatase activity
AS189_17800	COG1742	UPF0060 membrane protein
AS189_17810	COG1132	(ABC) transporter
AS189_17815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS189_17820	COG0765	amino acid transport
AS189_17825	COG1126	abc transporter atp-binding protein
AS189_17850	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AS189_17875	COG0746	molybdenum cofactor guanylyltransferase activity
AS189_17880	COG3103	Sh3 type 3 domain protein
AS189_17880	COG1388	LysM domain
AS189_17880	COG0791	NLP P60 protein
AS189_17885	COG0739	heme binding
AS189_17905	COG1278	Cold shock
AS189_17920	COG1061	Type III restriction enzyme res subunit
AS189_17925	COG2226	methyltransferase
AS189_17945	COG0745	RESPONSE REGULATOR receiver
AS189_17950	COG2205	protein histidine kinase activity
AS189_17970	COG0459	protein refolding
AS189_17985	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AS189_18035	COG1012	belongs to the aldehyde dehydrogenase family
AS189_18050	COG1028	Short-chain dehydrogenase reductase Sdr
AS189_18090	COG1937	Protein conserved in bacteria
AS189_18095	COG0561	phosphatase activity
AS189_18100	COG2190	(PTS) system
AS189_18100	COG1263	PTS System
AS189_18100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS189_18110	COG3711	transcriptional antiterminator
AS189_18125	COG2066	Belongs to the glutaminase family
AS189_18135	COG0277	FAD linked oxidase domain protein
AS189_18145	COG1414	Transcriptional regulator
AS189_18185	COG1597	lipid kinase activity
AS189_18200	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AS189_18215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AS189_18220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AS189_18230	COG1028	Short-chain dehydrogenase reductase Sdr
AS189_18240	COG0738	Major facilitator superfamily
AS189_18260	COG1309	transcriptional regulator
AS189_18270	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AS189_18275	COG3454	Phosphonate metabolism
AS189_18280	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AS189_18285	COG4778	phosphonate C-P lyase system protein PhnL
AS189_18290	COG4107	phosphonate C-P lyase system protein PhnK
AS189_18295	COG3627	carbon phosphorus lyase activity
AS189_18300	COG3626	phosphonate metabolism
AS189_18305	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
AS189_18310	COG3624	Phosphonate C-P lyase system protein PhnG
AS189_18315	COG2188	Transcriptional regulator
AS189_18325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS189_18340	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AS189_18345	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AS189_18350	COG3639	organic phosphonate transmembrane transporter activity
AS189_18355	COG1063	alcohol dehydrogenase
AS189_18400	COG1063	alcohol dehydrogenase
AS189_18430	COG5002	protein histidine kinase activity
AS189_18435	COG5002	protein histidine kinase activity
AS189_18440	COG0745	RESPONSE REGULATOR receiver
AS189_18510	COG0395	ABC-type sugar transport system, permease component
AS189_18515	COG4209	transmembrane transport
AS189_18595	COG1621	beta-fructofuranosidase activity
AS189_18600	COG4608	Belongs to the ABC transporter superfamily
AS189_18605	COG0444	Belongs to the ABC transporter superfamily
AS189_18610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS189_18615	COG0601	transmembrane transport
AS189_18625	COG1609	Transcriptional regulator
AS189_18635	COG3547	Transposase (IS116 IS110 IS902 family)
AS189_18645	COG1764	response to oxidative stress
AS189_18650	COG1473	amidohydrolase
AS189_18655	COG1063	alcohol dehydrogenase
AS189_18665	COG0789	Transcriptional regulator
AS189_18690	COG1760	l-serine dehydratase
AS189_18715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AS189_18720	COG0477	Major facilitator Superfamily
AS189_18730	COG1414	Transcriptional regulator
AS189_18760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AS189_18825	COG1404	Belongs to the peptidase S8 family
AS189_18855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AS189_18995	COG0582	viral genome integration into host DNA
AS189_19020	COG3842	ATPase activity
AS189_19040	COG0366	Alpha amylase catalytic
AS189_19045	COG3833	ABC-type maltose transport systems, permease component
AS189_19050	COG1175	transmembrane transport
AS189_19060	COG0366	Alpha amylase catalytic
AS189_19145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity