locus-tag	class	description
AOC05_00010	COG0588	phosphoglycerate mutase activity
AOC05_00015	COG0704	Plays a role in the regulation of phosphate uptake
AOC05_00020	COG5002	protein histidine kinase activity
AOC05_00040	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AOC05_00045	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AOC05_00050	COG0215	cysteine-tRNA ligase activity
AOC05_00055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOC05_00070	COG0366	Alpha amylase catalytic
AOC05_00075	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AOC05_00120	COG0277	FAD linked oxidase domain protein
AOC05_00135	COG3842	ATPase activity
AOC05_00255	COG1192	Involved in chromosome partitioning
AOC05_00370	COG0277	FAD linked oxidase domain protein
AOC05_00375	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AOC05_00380	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AOC05_00385	COG2814	Major facilitator Superfamily
AOC05_00400	COG1024	Enoyl-CoA hydratase
AOC05_00425	COG0477	Major facilitator Superfamily
AOC05_00440	COG1024	Enoyl-CoA hydratase
AOC05_00455	COG1940	carbohydrate kinase activity
AOC05_00460	COG0366	Alpha amylase catalytic
AOC05_00480	COG1940	carbohydrate kinase activity
AOC05_00535	COG0747	negative chemotaxis
AOC05_00550	COG4608	Belongs to the ABC transporter superfamily
AOC05_00580	COG0395	ABC-type sugar transport system, permease component
AOC05_00610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AOC05_00620	COG0730	response to heat
AOC05_00625	COG0477	Major facilitator Superfamily
AOC05_00635	COG1937	Protein conserved in bacteria
AOC05_00655	COG1940	carbohydrate kinase activity
AOC05_00655	COG1846	Transcriptional regulator
AOC05_00660	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AOC05_00665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AOC05_00670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOC05_00675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AOC05_00695	COG1940	carbohydrate kinase activity
AOC05_00700	COG1012	belongs to the aldehyde dehydrogenase family
AOC05_00705	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AOC05_00710	COG0251	oxidation-reduction process
AOC05_00715	COG0477	Major facilitator Superfamily
AOC05_00725	COG0028	Belongs to the TPP enzyme family
AOC05_00730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AOC05_00735	COG2826	transposase and inactivated derivatives, IS30 family
AOC05_00740	COG1940	carbohydrate kinase activity
AOC05_00820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AOC05_00825	COG4133	protoheme IX ABC transporter activity
AOC05_00830	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AOC05_00835	COG1172	Belongs to the binding-protein-dependent transport system permease family
AOC05_00840	COG1129	ABC transporter
AOC05_00850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOC05_00855	COG1609	Transcriptional regulator
AOC05_00865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AOC05_00880	COG1960	acyl-CoA dehydrogenase activity
AOC05_00890	COG1309	transcriptional regulator
AOC05_00910	COG1012	belongs to the aldehyde dehydrogenase family
AOC05_00920	COG2030	dehydratase
AOC05_00930	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AOC05_00940	COG1028	Short-chain dehydrogenase reductase Sdr
AOC05_00980	COG1024	Enoyl-CoA hydratase
AOC05_00995	COG2080	2 iron, 2 sulfur cluster binding
AOC05_01010	COG3608	succinylglutamate desuccinylase aspartoacylase
AOC05_01010	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AOC05_01015	COG1802	Transcriptional regulator
AOC05_01020	COG1335	isochorismatase
AOC05_01035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOC05_01040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AOC05_01045	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AOC05_01050	COG0066	3-isopropylmalate dehydratase activity
AOC05_01095	COG3842	ATPase activity
AOC05_01105	COG1940	carbohydrate kinase activity
AOC05_01110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOC05_01120	COG1028	Short-chain dehydrogenase reductase Sdr
AOC05_01135	COG0183	Belongs to the thiolase family
AOC05_01140	COG0183	Belongs to the thiolase family
AOC05_01145	COG0318	PFAM AMP-dependent synthetase and ligase
AOC05_01165	COG0183	Belongs to the thiolase family
AOC05_01175	COG2070	2-Nitropropane dioxygenase
AOC05_01240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOC05_01255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AOC05_01260	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AOC05_01265	COG0277	FAD linked oxidase domain protein
AOC05_01315	COG1028	Short-chain dehydrogenase reductase Sdr
AOC05_01330	COG1012	belongs to the aldehyde dehydrogenase family
AOC05_01340	COG1024	Enoyl-CoA hydratase
AOC05_01365	COG1136	(ABC) transporter
AOC05_01390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AOC05_01405	COG0459	protein refolding
AOC05_01420	COG2205	protein histidine kinase activity
AOC05_01425	COG0745	RESPONSE REGULATOR receiver
AOC05_01465	COG0673	inositol 2-dehydrogenase activity
AOC05_01480	COG3119	arylsulfatase activity
AOC05_01500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AOC05_01540	COG1278	Cold shock
AOC05_01555	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AOC05_01565	COG0739	heme binding
AOC05_01570	COG0791	NLP P60 protein
AOC05_01570	COG1388	LysM domain
AOC05_01570	COG3103	Sh3 type 3 domain protein
AOC05_01585	COG0746	molybdenum cofactor guanylyltransferase activity
AOC05_01620	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AOC05_01645	COG1126	abc transporter atp-binding protein
AOC05_01650	COG0765	amino acid transport
AOC05_01655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOC05_01660	COG1132	(ABC) transporter
AOC05_01665	COG1742	UPF0060 membrane protein
AOC05_01670	COG2962	Rard protein
AOC05_01685	COG0483	inositol monophosphate 1-phosphatase activity
AOC05_01700	COG0045	succinate-CoA ligase (ADP-forming) activity
AOC05_01725	COG1414	Transcriptional regulator
AOC05_01735	COG0477	Major facilitator Superfamily
AOC05_01765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AOC05_01790	COG1760	l-serine dehydratase
AOC05_01820	COG1396	sequence-specific DNA binding
AOC05_01835	COG0028	Belongs to the TPP enzyme family
AOC05_01855	COG1309	transcriptional regulator
AOC05_01860	COG1090	epimerase
AOC05_01880	COG2186	Transcriptional regulator
AOC05_01890	COG1027	Aspartate ammonia-lyase
AOC05_01950	COG1185	polyribonucleotide nucleotidyltransferase activity
AOC05_01985	COG2801	Transposase and inactivated derivatives
AOC05_02035	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AOC05_02055	COG3634	alkyl hydroperoxide reductase activity
AOC05_02070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AOC05_02090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOC05_02090	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AOC05_02100	COG1278	Cold shock
AOC05_02125	COG0477	Major facilitator Superfamily
AOC05_02135	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AOC05_02140	COG1472	Belongs to the glycosyl hydrolase 3 family
AOC05_02145	COG0138	bifunctional purine biosynthesis protein purh
AOC05_02155	COG2838	Isocitrate dehydrogenase
AOC05_02185	COG0673	inositol 2-dehydrogenase activity
AOC05_02190	COG4213	ABC transporter substrate-binding protein
AOC05_02195	COG4214	carbohydrate transport
AOC05_02220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AOC05_02225	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AOC05_02240	COG2197	response regulator
AOC05_02265	COG0180	Tryptophanyl-tRNA synthetase
AOC05_02285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AOC05_02300	COG2009	succinate dehydrogenase
AOC05_02310	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AOC05_02310	COG1473	amidohydrolase
AOC05_02355	COG3956	TIGRFAM MazG family protein
AOC05_02365	COG0148	phosphopyruvate hydratase activity
AOC05_02410	COG0861	Integral membrane protein TerC family
AOC05_02415	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AOC05_02430	COG2017	converts alpha-aldose to the beta-anomer
AOC05_02440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AOC05_02445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOC05_02455	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AOC05_02465	COG1331	Highly conserved protein containing a thioredoxin domain
AOC05_02500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AOC05_02505	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AOC05_02540	COG0114	fumarate hydratase activity
AOC05_02545	COG0288	reversible hydration of carbon dioxide
AOC05_02555	COG1494	fructose-1,6-bisphosphatase
AOC05_02565	COG1482	cell wall glycoprotein biosynthetic process
AOC05_02570	COG1316	TRANSCRIPTIONal
AOC05_02625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOC05_02675	COG0714	Associated with various cellular activities
AOC05_02680	COG0084	hydrolase, TatD family'
AOC05_02685	COG3583	domain protein
AOC05_02690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AOC05_02695	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AOC05_02700	COG0488	(ABC) transporter
AOC05_02715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AOC05_02730	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AOC05_02735	COG0193	aminoacyl-tRNA hydrolase activity
AOC05_02745	COG2197	response regulator
AOC05_02750	COG2197	response regulator
AOC05_02760	COG0730	response to heat
AOC05_02785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AOC05_02810	COG1215	transferase activity, transferring glycosyl groups
AOC05_02875	COG0822	iron-sulfur transferase activity
AOC05_02885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AOC05_02895	COG5002	protein histidine kinase activity
AOC05_02925	COG5002	protein histidine kinase activity
AOC05_02930	COG0745	RESPONSE REGULATOR receiver
AOC05_02950	COG3979	chitinase
AOC05_02975	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AOC05_02985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOC05_03005	COG0477	Major facilitator Superfamily
AOC05_03015	COG2801	Transposase and inactivated derivatives
AOC05_03020	COG4770	biotin carboxylase activity
AOC05_03035	COG0424	maF-like protein
AOC05_03060	COG2409	Drug exporters of the RND superfamily
AOC05_03095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AOC05_03145	COG0714	Associated with various cellular activities
AOC05_03195	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AOC05_03205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOC05_03225	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AOC05_03230	COG0154	amidase activity
AOC05_03235	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AOC05_03260	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AOC05_03265	COG0583	DNA-binding transcription factor activity
AOC05_03270	COG1063	alcohol dehydrogenase
AOC05_03275	COG0156	8-amino-7-oxononanoate synthase activity
AOC05_03280	COG1228	amidohydrolase
AOC05_03295	COG1940	carbohydrate kinase activity
AOC05_03310	COG1349	DNA-binding transcription factor activity
AOC05_03315	COG2837	iron assimilation
AOC05_03320	COG2822	iron ion transport
AOC05_03330	COG0588	phosphoglycerate mutase activity
AOC05_03355	COG2183	response to ionizing radiation
AOC05_03360	COG2873	o-acetylhomoserine
AOC05_03365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOC05_03400	COG0423	glycine-tRNA ligase activity
AOC05_03420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AOC05_03430	COG2239	Acts as a magnesium transporter
AOC05_03435	COG1309	transcriptional regulator
AOC05_03440	COG1511	domain protein
AOC05_03465	COG0358	DNA primase activity
AOC05_03480	COG2814	Major facilitator Superfamily
AOC05_03500	COG0297	glycogen (starch) synthase activity
AOC05_03525	COG0052	Belongs to the universal ribosomal protein uS2 family
AOC05_03530	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AOC05_03535	COG0528	UMP kinase activity
AOC05_03540	COG0233	cytoplasmic translational termination
AOC05_03545	COG0575	Belongs to the CDS family
AOC05_03570	COG3275	phosphorelay sensor kinase activity
AOC05_03600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOC05_03605	COG1522	sequence-specific DNA binding
AOC05_03615	COG0022	dehydrogenase e1 component
AOC05_03620	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOC05_03635	COG1309	transcriptional regulator
AOC05_03640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AOC05_03650	COG1960	acyl-CoA dehydrogenase activity
AOC05_03675	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AOC05_03680	COG0750	zinc metalloprotease
AOC05_03700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AOC05_03710	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOC05_03710	COG1902	pentaerythritol trinitrate reductase activity
AOC05_03745	COG0442	prolyl-tRNA aminoacylation
AOC05_03755	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
AOC05_03770	COG0779	Required for maturation of 30S ribosomal subunits
AOC05_03775	COG0195	Participates in both transcription termination and antitermination
AOC05_03780	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AOC05_03785	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AOC05_03820	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AOC05_03845	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AOC05_03850	COG1185	polyribonucleotide nucleotidyltransferase activity
AOC05_03855	COG0612	Peptidase, M16
AOC05_03900	COG0315	cyclic pyranopterin monophosphate synthase activity
AOC05_03905	COG0315	cyclic pyranopterin monophosphate synthase activity
AOC05_03905	COG0521	Mo-molybdopterin cofactor biosynthetic process
AOC05_03915	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AOC05_03925	COG0596	Alpha beta hydrolase
AOC05_03930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOC05_03935	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AOC05_03940	COG1674	ftsk spoiiie
AOC05_03950	COG1546	Belongs to the CinA family
AOC05_03950	COG1058	Belongs to the CinA family
AOC05_03970	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AOC05_03975	COG2137	regulation of response to DNA damage stimulus
AOC05_03985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AOC05_03990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AOC05_03995	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AOC05_04000	COG2813	Specifically methylates the guanine in position
AOC05_04005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AOC05_04015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AOC05_04025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AOC05_04030	COG0131	Imidazoleglycerol-phosphate dehydratase
AOC05_04035	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AOC05_04040	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AOC05_04060	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AOC05_04065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AOC05_04070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AOC05_04075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOC05_04085	COG2814	Major facilitator Superfamily
AOC05_04110	COG0318	PFAM AMP-dependent synthetase and ligase
AOC05_04130	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AOC05_04135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOC05_04135	COG0072	phenylalanine-tRNA ligase activity
AOC05_04200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AOC05_04205	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AOC05_04210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AOC05_04215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AOC05_04220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AOC05_04225	COG1438	arginine binding
AOC05_04230	COG0137	argininosuccinate synthase activity
AOC05_04235	COG0165	Argininosuccinate lyase
AOC05_04255	COG2094	Belongs to the DNA glycosylase MPG family
AOC05_04265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AOC05_04275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AOC05_04320	COG0647	UMP catabolic process
AOC05_04335	COG0497	DNA recombination
AOC05_04340	COG0504	CTP synthase activity
AOC05_04385	COG1028	Short-chain dehydrogenase reductase Sdr
AOC05_04390	COG3387	PFAM Glycoside hydrolase 15-related
AOC05_04395	COG2816	NAD+ diphosphatase activity
AOC05_04410	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AOC05_04415	COG2079	MmgE PrpD family protein
AOC05_04435	COG3290	protein histidine kinase activity
AOC05_04465	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AOC05_04470	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AOC05_04485	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AOC05_04495	COG1160	GTP binding
AOC05_04520	COG1960	acyl-CoA dehydrogenase activity
AOC05_04540	COG0509	glycine decarboxylation via glycine cleavage system
AOC05_04545	COG1716	ATPase activity
AOC05_04570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AOC05_04570	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AOC05_04575	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AOC05_04610	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AOC05_04620	COG0515	serine threonine protein kinase
AOC05_04620	COG2815	serine threonine protein kinase
AOC05_04635	COG0142	geranyltranstransferase activity
AOC05_04655	COG2001	Belongs to the MraZ family
AOC05_04660	COG0275	rRNA processing
AOC05_04670	COG0768	penicillin binding
AOC05_04685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AOC05_04690	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AOC05_04700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AOC05_04710	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AOC05_04715	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AOC05_04730	COG1799	cell septum assembly
AOC05_04745	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AOC05_04755	COG0587	DNA-directed DNA polymerase activity
AOC05_04765	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AOC05_04770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AOC05_04785	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AOC05_04790	COG0174	glutamine synthetase
AOC05_04795	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AOC05_04805	COG2066	Belongs to the glutaminase family
AOC05_04845	COG4974	Belongs to the 'phage' integrase family
AOC05_05035	COG2801	Transposase and inactivated derivatives
AOC05_05060	COG0305	Participates in initiation and elongation during chromosome replication
AOC05_05100	COG4974	Belongs to the 'phage' integrase family
AOC05_05130	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AOC05_05135	COG0321	lipoyl(octanoyl) transferase activity
AOC05_05145	COG0793	Belongs to the peptidase S41A family
AOC05_05145	COG4946	Tricorn protease homolog
AOC05_05160	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOC05_05165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOC05_05170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AOC05_05190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AOC05_05215	COG1271	oxidase subunit
AOC05_05220	COG1294	oxidase, subunit
AOC05_05225	COG4988	ABC transporter
AOC05_05270	COG0756	dUTP diphosphatase activity
AOC05_05295	COG0569	domain protein
AOC05_05300	COG0531	amino acid
AOC05_05305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AOC05_05310	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AOC05_05315	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AOC05_05320	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AOC05_05340	COG0667	Aldo Keto reductase
AOC05_05350	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOC05_05350	COG1024	Enoyl-CoA hydratase
AOC05_05355	COG0183	Belongs to the thiolase family
AOC05_05360	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AOC05_05385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOC05_05400	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AOC05_05425	COG2072	flavoprotein involved in K transport
AOC05_05435	COG2076	Multidrug Resistance protein
AOC05_05475	COG0242	peptide deformylase activity
AOC05_05480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AOC05_05490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AOC05_05495	COG3201	nicotinamide mononucleotide transporter
AOC05_05515	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AOC05_05520	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AOC05_05525	COG0140	phosphoribosyl-ATP diphosphatase activity
AOC05_05530	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AOC05_05535	COG0107	imidazoleglycerol-phosphate synthase activity
AOC05_05545	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AOC05_05565	COG0134	indole-3-glycerol-phosphate synthase activity
AOC05_05570	COG0133	tryptophan synthase activity
AOC05_05575	COG0159	tryptophan synthase activity
AOC05_05585	COG0067	glutamate synthase
AOC05_05585	COG0070	glutamate synthase
AOC05_05585	COG0069	glutamate synthase activity
AOC05_05625	COG3654	unkown
AOC05_05635	COG0019	diaminopimelate decarboxylase activity
AOC05_05645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AOC05_05650	COG2261	transglycosylase associated protein
AOC05_05685	COG0589	response to stress
AOC05_05690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AOC05_05695	COG0667	Aldo Keto reductase
AOC05_05700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AOC05_05705	COG1121	(ABC) transporter
AOC05_05745	COG0542	response to heat
AOC05_05760	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOC05_05770	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AOC05_05780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AOC05_05785	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AOC05_05790	COG1053	succinate dehydrogenase
AOC05_05855	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AOC05_05890	COG3285	dna ligase
AOC05_05890	COG1793	dna ligase
AOC05_05900	COG0574	Belongs to the PEP-utilizing enzyme family
AOC05_05900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AOC05_05940	COG1063	alcohol dehydrogenase
AOC05_05950	COG0745	RESPONSE REGULATOR receiver
AOC05_05975	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AOC05_06000	COG0589	response to stress
AOC05_06005	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AOC05_06015	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AOC05_06035	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOC05_06045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOC05_06080	COG0804	urea catabolic process
AOC05_06085	COG1902	pentaerythritol trinitrate reductase activity
AOC05_06100	COG2130	NADP-dependent
AOC05_06120	COG2226	methyltransferase
AOC05_06140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AOC05_06145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AOC05_06160	COG1028	Short-chain dehydrogenase reductase Sdr
AOC05_06165	COG3119	arylsulfatase activity
AOC05_06170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOC05_06185	COG1940	carbohydrate kinase activity
AOC05_06185	COG1846	Transcriptional regulator
AOC05_06200	COG2268	Band 7 protein
AOC05_06235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AOC05_06250	COG1902	pentaerythritol trinitrate reductase activity
AOC05_06300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOC05_06305	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AOC05_06310	COG1643	Atp-dependent helicase
AOC05_06315	COG1028	Short-chain dehydrogenase reductase Sdr
AOC05_06320	COG0783	Belongs to the Dps family
AOC05_06325	COG0009	L-threonylcarbamoyladenylate synthase
AOC05_06330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AOC05_06370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AOC05_06385	COG0673	inositol 2-dehydrogenase activity
AOC05_06405	COG0436	Aminotransferase
AOC05_06410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOC05_06430	COG2050	protein possibly involved in aromatic compounds catabolism
AOC05_06455	COG0539	negative regulation of cytoplasmic translation
AOC05_06460	COG3152	Membrane
AOC05_06465	COG1739	Uncharacterized protein family UPF0029
AOC05_06470	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AOC05_06470	COG0237	dephospho-CoA kinase activity
AOC05_06480	COG0556	nucleotide-excision repair
AOC05_06500	COG4106	trans-aconitate 2-methyltransferase activity
AOC05_06510	COG3550	peptidyl-serine autophosphorylation
AOC05_06530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOC05_06540	COG0546	phosphoglycolate phosphatase activity
AOC05_06550	COG0322	excinuclease ABC activity
AOC05_06555	COG1660	Displays ATPase and GTPase activities
AOC05_06565	COG1481	regulation of sporulation
AOC05_06575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AOC05_06580	COG0126	phosphoglycerate kinase activity
AOC05_06585	COG0149	triose-phosphate isomerase activity
AOC05_06590	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AOC05_06595	COG0363	glucosamine-6-phosphate deaminase activity
AOC05_06615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AOC05_06625	COG0109	protoheme IX farnesyltransferase activity
AOC05_06665	COG0396	ATPase activity
AOC05_06670	COG2151	metal-sulfur cluster biosynthetic enzyme
AOC05_06675	COG0318	PFAM AMP-dependent synthetase and ligase
AOC05_06680	COG0183	Belongs to the thiolase family
AOC05_06690	COG1122	ATPase activity
AOC05_06700	COG0488	(ABC) transporter
AOC05_06725	COG1028	Short-chain dehydrogenase reductase Sdr
AOC05_06730	COG1028	Short-chain dehydrogenase reductase Sdr
AOC05_06735	COG3830	Belongs to the UPF0237 family
AOC05_06735	COG0560	Phosphoserine phosphatase
AOC05_06740	COG1119	ATPase activity
AOC05_06745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOC05_06755	COG0254	rRNA binding
AOC05_06775	COG2855	membrane
AOC05_06785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AOC05_06790	COG0297	glycogen (starch) synthase activity
AOC05_06795	COG1403	HNH endonuclease
AOC05_06825	COG1028	Short-chain dehydrogenase reductase Sdr
AOC05_06845	COG0577	efflux transmembrane transporter activity
AOC05_06845	COG1136	(ABC) transporter
AOC05_06905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AOC05_06925	COG0656	L-ascorbic acid biosynthetic process
AOC05_06930	COG1968	undecaprenyl-diphosphatase activity
AOC05_06935	COG0215	cysteine-tRNA ligase activity
AOC05_06945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AOC05_06960	COG1222	aaa ATPase
AOC05_06965	COG4122	O-methyltransferase activity
AOC05_06975	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AOC05_06980	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AOC05_06985	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AOC05_07010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AOC05_07015	COG0805	protein transport
AOC05_07020	COG4581	dead DEAH box helicase
AOC05_07030	COG1216	Glycosyl transferase, family 2
AOC05_07055	COG2364	Membrane
AOC05_07060	COG2226	methyltransferase
AOC05_07065	COG0242	peptide deformylase activity
AOC05_07070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AOC05_07075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AOC05_07080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AOC05_07105	COG0494	nUDIX hydrolase
AOC05_07120	COG0494	nUDIX hydrolase
AOC05_07150	COG4644	lycopene metabolic process
AOC05_07160	COG1129	ABC transporter
AOC05_07180	COG1522	sequence-specific DNA binding
AOC05_07185	COG3142	Participates in the control of copper homeostasis
AOC05_07190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AOC05_07195	COG1845	cytochrome c oxidase, subunit III
AOC05_07200	COG2010	Cytochrome c
AOC05_07205	COG0723	plastoquinol--plastocyanin reductase activity
AOC05_07210	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AOC05_07230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AOC05_07235	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AOC05_07255	COG0667	Aldo Keto reductase
AOC05_07260	COG0167	dihydroorotate dehydrogenase activity
AOC05_07280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AOC05_07285	COG1381	Involved in DNA repair and RecF pathway recombination
AOC05_07290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AOC05_07295	COG3590	peptidase
AOC05_07305	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AOC05_07315	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AOC05_07330	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AOC05_07335	COG0484	heat shock protein binding
AOC05_07340	COG1420	regulation of RNA biosynthetic process
AOC05_07355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AOC05_07360	COG0481	GTPase activity
AOC05_07370	COG0268	Binds directly to 16S ribosomal RNA
AOC05_07390	COG1307	EDD domain protein, DegV family
AOC05_07395	COG0495	leucyl-tRNA aminoacylation
AOC05_07400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AOC05_07405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AOC05_07410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AOC05_07415	COG2390	Transcriptional regulator
AOC05_07420	COG0656	L-ascorbic acid biosynthetic process
AOC05_07460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AOC05_07465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AOC05_07475	COG1758	RNA polymerase activity
AOC05_07480	COG0194	GDP metabolic process
AOC05_07485	COG0194	GDP metabolic process
AOC05_07490	COG0284	orotidine-5'-phosphate decarboxylase activity
AOC05_07495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AOC05_07500	COG0505	Belongs to the CarA family
AOC05_07510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AOC05_07515	COG0540	Belongs to the ATCase OTCase family
AOC05_07520	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AOC05_07530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AOC05_07535	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AOC05_07545	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AOC05_07550	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AOC05_07555	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AOC05_07560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AOC05_07565	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AOC05_07570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AOC05_07575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AOC05_07590	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AOC05_07620	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AOC05_07625	COG0124	histidyl-tRNA synthetase
AOC05_07635	COG1196	nuclear chromosome segregation
AOC05_07645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOC05_07650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AOC05_07655	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AOC05_07665	COG2255	four-way junction helicase activity
AOC05_07670	COG0632	four-way junction helicase activity
AOC05_07675	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AOC05_07680	COG0217	transcriptional regulatory protein
AOC05_07685	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AOC05_07690	COG0367	asparagine synthase
AOC05_07715	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AOC05_07730	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AOC05_07735	COG0587	DNA-directed DNA polymerase activity
AOC05_07745	COG0456	acetyltransferase
AOC05_07750	COG1316	TRANSCRIPTIONal
AOC05_07760	COG2135	peptidase activity
AOC05_07795	COG0318	PFAM AMP-dependent synthetase and ligase
AOC05_07810	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AOC05_07815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AOC05_07820	COG1780	Probably involved in ribonucleotide reductase function
AOC05_07835	COG0583	DNA-binding transcription factor activity
AOC05_07845	COG1012	belongs to the aldehyde dehydrogenase family
AOC05_07890	COG0714	Associated with various cellular activities
AOC05_07915	COG3012	SEC-C Motif Domain Protein
AOC05_07940	COG0799	negative regulation of ribosome biogenesis
AOC05_07950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AOC05_07960	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AOC05_07965	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AOC05_07970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AOC05_07980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AOC05_07985	COG0352	thiamine-phosphate diphosphorylase activity
AOC05_07985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AOC05_07985	COG0351	phosphomethylpyrimidine kinase
AOC05_07990	COG1530	ribonuclease E activity
AOC05_08000	COG0105	UTP biosynthetic process
AOC05_08010	COG0285	dihydrofolate synthase activity
AOC05_08015	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AOC05_08025	COG3189	MarR family transcriptional regulator
AOC05_08035	COG0525	valine-tRNA ligase activity
AOC05_08050	COG0477	Major facilitator Superfamily
AOC05_08055	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AOC05_08060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AOC05_08065	COG0740	serine-type endopeptidase activity
AOC05_08070	COG0740	serine-type endopeptidase activity
AOC05_08075	COG0544	peptidyl-prolyl cis-trans isomerase activity
AOC05_08095	COG0698	ribose 5-phosphate isomerase
AOC05_08140	COG1946	Acyl-CoA thioesterase
AOC05_08170	COG2985	domain, Protein
AOC05_08185	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AOC05_08190	COG0549	Belongs to the carbamate kinase family
AOC05_08200	COG0477	Major facilitator Superfamily
AOC05_08235	COG0494	nUDIX hydrolase
AOC05_08250	COG2226	methyltransferase
AOC05_08335	COG0477	Major facilitator Superfamily
AOC05_08340	COG0583	DNA-binding transcription factor activity
AOC05_08365	COG0702	epimerase
AOC05_08415	COG1022	Amp-dependent synthetase and ligase
AOC05_08425	COG0667	Aldo Keto reductase
AOC05_08450	COG5433	transposase activity
AOC05_08480	COG2217	Heavy metal translocating P-type atpase
AOC05_08510	COG3237	CsbD-like
AOC05_08520	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
AOC05_08530	COG2826	transposase and inactivated derivatives, IS30 family
AOC05_08585	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AOC05_08595	COG3547	Transposase (IS116 IS110 IS902 family)
AOC05_08605	COG2197	response regulator
AOC05_08635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AOC05_08690	COG1012	belongs to the aldehyde dehydrogenase family
AOC05_08695	COG0473	3-isopropylmalate dehydrogenase activity
AOC05_08700	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOC05_08710	COG0531	amino acid
AOC05_08720	COG1012	belongs to the aldehyde dehydrogenase family
AOC05_08755	COG1764	response to oxidative stress
AOC05_08760	COG1846	Transcriptional regulator
AOC05_08770	COG1064	alcohol dehydrogenase
AOC05_08780	COG5492	domain, Protein
AOC05_08780	COG4932	domain protein
AOC05_08795	COG5002	protein histidine kinase activity
AOC05_08800	COG0745	RESPONSE REGULATOR receiver
AOC05_08810	COG1937	Protein conserved in bacteria
AOC05_08830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AOC05_08840	COG0659	secondary active sulfate transmembrane transporter activity
AOC05_08845	COG0789	Transcriptional regulator
AOC05_08885	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AOC05_08890	COG1854	S-ribosylhomocysteine lyase activity
AOC05_08935	COG0798	PFAM Bile acid sodium symporter
AOC05_08970	COG0076	glutamate decarboxylase activity
AOC05_08975	COG2890	protein-(glutamine-N5) methyltransferase activity
AOC05_09025	COG0242	peptide deformylase activity
AOC05_09030	COG0477	Major facilitator Superfamily
AOC05_09040	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AOC05_09070	COG2197	response regulator
AOC05_09075	COG4585	Histidine kinase
AOC05_09105	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AOC05_09110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOC05_09120	COG1045	serine acetyltransferase
AOC05_09125	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AOC05_09135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AOC05_09140	COG1414	Transcriptional regulator
AOC05_09150	COG2176	DNA-directed DNA polymerase activity
AOC05_09175	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AOC05_09190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AOC05_09195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AOC05_09200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AOC05_09210	COG4974	Belongs to the 'phage' integrase family
AOC05_09220	COG0659	secondary active sulfate transmembrane transporter activity
AOC05_09230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AOC05_09230	COG0758	DNA mediated transformation
AOC05_09235	COG0606	chelatase, subunit chli
AOC05_09240	COG0792	nuclease activity
AOC05_09250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AOC05_09260	COG0681	Belongs to the peptidase S26 family
AOC05_09265	COG0335	large ribosomal subunit rRNA binding
AOC05_09270	COG0336	Belongs to the RNA methyltransferase TrmD family
AOC05_09275	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AOC05_09280	COG1837	Belongs to the UPF0109 family
AOC05_09285	COG0228	four-way junction DNA binding
AOC05_09295	COG2514	catechol 2,3-dioxygenase activity
AOC05_09315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AOC05_09340	COG0477	Major facilitator Superfamily
AOC05_09350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AOC05_09355	COG0318	PFAM AMP-dependent synthetase and ligase
AOC05_09360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AOC05_09385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AOC05_09395	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AOC05_09415	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AOC05_09420	COG0300	oxidoreductase activity
AOC05_09440	COG2268	Band 7 protein
AOC05_09445	COG0742	ribosomal rna small subunit methyltransferase
AOC05_09455	COG1461	Dihydroxyacetone kinase
AOC05_09475	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AOC05_09480	COG1316	TRANSCRIPTIONal
AOC05_09490	COG2813	Specifically methylates the guanine in position
AOC05_09495	COG1181	Belongs to the D-alanine--D-alanine ligase family
AOC05_09500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AOC05_09510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AOC05_09520	COG0066	3-isopropylmalate dehydratase activity
AOC05_09525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AOC05_09530	COG1414	Transcriptional regulator
AOC05_09565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOC05_09585	COG0179	Fumarylacetoacetate (FAA) hydrolase
AOC05_09590	COG2116	formate transmembrane transporter activity
AOC05_09605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AOC05_09610	COG0473	3-isopropylmalate dehydrogenase activity
AOC05_09615	COG0415	Belongs to the DNA photolyase family
AOC05_09660	COG4585	Histidine kinase
AOC05_09665	COG2197	response regulator
AOC05_09675	COG1175	transmembrane transport
AOC05_09680	COG1653	transport
AOC05_09700	COG1136	(ABC) transporter
AOC05_09725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AOC05_09730	COG0440	acetolactate synthase activity
AOC05_09735	COG0028	Belongs to the TPP enzyme family
AOC05_09740	COG0129	dihydroxy-acid dehydratase activity
AOC05_09765	COG0747	negative chemotaxis
AOC05_09770	COG0579	oxidoreductase
AOC05_09775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOC05_09785	COG2814	Major facilitator Superfamily
AOC05_09790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOC05_09815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AOC05_09830	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AOC05_09835	COG3639	organic phosphonate transmembrane transporter activity
AOC05_09840	COG3639	organic phosphonate transmembrane transporter activity
AOC05_09855	COG0179	Fumarylacetoacetate (FAA) hydrolase
AOC05_09890	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AOC05_09900	COG1113	amino acid transport
AOC05_09935	COG0419	ATPase involved in DNA repair
AOC05_09940	COG0420	3'-5' exonuclease activity
AOC05_09955	COG2149	membrane
AOC05_09985	COG0586	Pfam SNARE associated Golgi protein
AOC05_09990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AOC05_09995	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AOC05_10010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AOC05_10020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AOC05_10025	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AOC05_10030	COG1335	isochorismatase
AOC05_10045	COG0363	glucosamine-6-phosphate deaminase activity
AOC05_10060	COG3118	belongs to the thioredoxin family
AOC05_10075	COG0628	permease
AOC05_10090	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AOC05_10095	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AOC05_10105	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AOC05_10110	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AOC05_10120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AOC05_10125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AOC05_10130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AOC05_10135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AOC05_10140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AOC05_10145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AOC05_10150	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AOC05_10155	COG0356	it plays a direct role in the translocation of protons across the membrane
AOC05_10200	COG2890	protein-(glutamine-N5) methyltransferase activity
AOC05_10205	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AOC05_10215	COG0083	homoserine kinase activity
AOC05_10220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AOC05_10225	COG0460	homoserine dehydrogenase
AOC05_10230	COG0019	diaminopimelate decarboxylase activity
AOC05_10235	COG0018	arginyl-trna synthetase
AOC05_10270	COG2813	Specifically methylates the guanine in position
AOC05_10290	COG1643	Atp-dependent helicase
AOC05_10305	COG0318	PFAM AMP-dependent synthetase and ligase
AOC05_10310	COG0537	adenosine 5'-monophosphoramidase activity
AOC05_10315	COG1064	alcohol dehydrogenase
AOC05_10325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AOC05_10330	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AOC05_10350	COG1120	ATPase activity
AOC05_10380	COG3265	gluconokinase activity
AOC05_10385	COG3265	gluconokinase activity
AOC05_10390	COG4948	Mandelate Racemase Muconate Lactonizing
AOC05_10400	COG1904	glucuronate isomerase
AOC05_10405	COG1609	Transcriptional regulator
AOC05_10410	COG0673	inositol 2-dehydrogenase activity
AOC05_10420	COG0673	inositol 2-dehydrogenase activity
AOC05_10430	COG1609	Transcriptional regulator
AOC05_10440	COG1175	transmembrane transport
AOC05_10445	COG0395	ABC-type sugar transport system, permease component
AOC05_10455	COG0567	Dehydrogenase, E1 component
AOC05_10455	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOC05_10495	COG1595	DNA-templated transcription, initiation
AOC05_10505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AOC05_10515	COG0483	inositol monophosphate 1-phosphatase activity
AOC05_10575	COG1472	Belongs to the glycosyl hydrolase 3 family
AOC05_10590	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AOC05_10605	COG2177	Part of the ABC transporter FtsEX involved in
AOC05_10615	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AOC05_10655	COG0438	transferase activity, transferring glycosyl groups
AOC05_10700	COG0673	inositol 2-dehydrogenase activity
AOC05_10720	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AOC05_10730	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AOC05_10755	COG0579	oxidoreductase
AOC05_10770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AOC05_10775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AOC05_10785	COG0463	Glycosyl transferase, family 2
AOC05_10820	COG1216	Glycosyl transferase, family 2
AOC05_10835	COG1674	ftsk spoiiie
AOC05_10855	COG2902	Dehydrogenase
AOC05_10890	COG0653	protein targeting
AOC05_10895	COG3214	Protein conserved in bacteria
AOC05_10900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AOC05_10910	COG5401	PFAM Sporulation and spore germination
AOC05_10920	COG0745	RESPONSE REGULATOR receiver
AOC05_10940	COG0714	Associated with various cellular activities
AOC05_10965	COG4172	Belongs to the ABC transporter superfamily
AOC05_10970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AOC05_10975	COG0601	transmembrane transport
AOC05_10990	COG0482	sulfurtransferase activity
AOC05_11005	COG0302	gtp cyclohydrolase
AOC05_11015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AOC05_11035	COG0484	heat shock protein binding
AOC05_11040	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AOC05_11050	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AOC05_11055	COG2086	electron transfer activity
AOC05_11070	COG1842	Phage shock protein A
AOC05_11075	COG0656	L-ascorbic acid biosynthetic process
AOC05_11085	COG0667	Aldo Keto reductase
AOC05_11095	COG3585	molybdate ion transport
AOC05_11140	COG0251	oxidation-reduction process
AOC05_11185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOC05_11195	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AOC05_11200	COG0028	Belongs to the TPP enzyme family
AOC05_11215	COG1024	Enoyl-CoA hydratase
AOC05_11225	COG1024	Enoyl-CoA hydratase
AOC05_11240	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AOC05_11260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOC05_11265	COG0318	PFAM AMP-dependent synthetase and ligase
AOC05_11270	COG1024	Enoyl-CoA hydratase
AOC05_11275	COG1024	Enoyl-CoA hydratase
AOC05_11275	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOC05_11280	COG0183	Belongs to the thiolase family
AOC05_11285	COG1960	acyl-CoA dehydrogenase activity
AOC05_11290	COG1024	Enoyl-CoA hydratase
AOC05_11300	COG1028	Short-chain dehydrogenase reductase Sdr
AOC05_11305	COG0318	PFAM AMP-dependent synthetase and ligase
AOC05_11310	COG1024	Enoyl-CoA hydratase
AOC05_11325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AOC05_11365	COG1615	UPF0182 protein
AOC05_11370	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AOC05_11415	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AOC05_11455	COG0210	DNA helicase
AOC05_11475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOC05_11480	COG0765	amino acid transport
AOC05_11500	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AOC05_11515	COG0181	hydroxymethylbilane synthase activity
AOC05_11535	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AOC05_11570	COG2154	pterin-4-alpha-carbinolamine dehydratase
AOC05_11575	COG2022	thiamine diphosphate biosynthetic process
AOC05_11585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOC05_11590	COG0352	thiamine-phosphate diphosphorylase activity
AOC05_11620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOC05_11625	COG2072	flavoprotein involved in K transport
AOC05_11655	COG0842	Transport permease protein
AOC05_11655	COG1129	ABC transporter
AOC05_11690	COG2755	lipolytic protein G-D-S-L family
AOC05_11690	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AOC05_11700	COG0006	proline dipeptidase activity
AOC05_11710	COG2239	Acts as a magnesium transporter
AOC05_11730	COG1595	DNA-templated transcription, initiation
AOC05_11735	COG4122	O-methyltransferase activity
AOC05_11745	COG0519	Catalyzes the synthesis of GMP from XMP
AOC05_11760	COG1126	abc transporter atp-binding protein
AOC05_11765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOC05_11770	COG0765	amino acid transport
AOC05_11775	COG0765	amino acid transport
AOC05_11780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AOC05_11805	COG2171	N-acyltransferase activity
AOC05_11835	COG3226	Transcriptional regulator
AOC05_11885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AOC05_11890	COG0601	transmembrane transport
AOC05_11905	COG4166	transmembrane transport
AOC05_11955	COG4221	oxidoreductase activity
AOC05_11990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AOC05_11995	COG0012	GTP binding
AOC05_12000	COG1322	Protein conserved in bacteria
AOC05_12005	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AOC05_12015	COG1570	exodeoxyribonuclease VII activity
AOC05_12020	COG1722	exodeoxyribonuclease VII activity
AOC05_12025	COG2326	polyphosphate kinase activity
AOC05_12045	COG1609	Transcriptional regulator
AOC05_12050	COG2971	BadF BadG BcrA BcrD
AOC05_12060	COG2814	Major facilitator Superfamily
AOC05_12065	COG0626	cystathionine gamma-synthase activity
AOC05_12085	COG0598	Magnesium transport protein CorA
AOC05_12095	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AOC05_12105	COG0156	8-amino-7-oxononanoate synthase activity
AOC05_12110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AOC05_12115	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AOC05_12130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOC05_12135	COG0477	Major facilitator Superfamily
AOC05_12140	COG0778	Nitroreductase
AOC05_12155	COG0039	L-malate dehydrogenase activity
AOC05_12165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AOC05_12170	COG1309	transcriptional regulator
AOC05_12175	COG1131	(ABC) transporter
AOC05_12190	COG0412	Dienelactone hydrolase
AOC05_12205	COG0488	(ABC) transporter
AOC05_12225	COG2217	Heavy metal translocating P-type atpase
AOC05_12250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AOC05_12260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AOC05_12265	COG0509	glycine decarboxylation via glycine cleavage system
AOC05_12270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AOC05_12275	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AOC05_12275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AOC05_12280	COG1113	amino acid transport
AOC05_12305	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOC05_12335	COG3711	transcriptional antiterminator
AOC05_12340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AOC05_12340	COG2190	(PTS) system
AOC05_12340	COG1263	PTS System
AOC05_12345	COG2190	(PTS) system
AOC05_12345	COG1263	PTS System
AOC05_12345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AOC05_12350	COG0135	phosphoribosylanthranilate isomerase activity
AOC05_12380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AOC05_12385	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AOC05_12410	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AOC05_12410	COG0519	Catalyzes the synthesis of GMP from XMP
AOC05_12430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AOC05_12435	COG0516	GMP reductase activity
AOC05_12455	COG2217	Heavy metal translocating P-type atpase
AOC05_12460	COG0459	protein refolding
AOC05_12465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AOC05_12480	COG4604	ABC transporter, ATP-binding protein
AOC05_12485	COG4605	iron ion homeostasis
AOC05_12490	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AOC05_12495	COG4607	ABC-type enterochelin transport system periplasmic component
AOC05_12505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AOC05_12510	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AOC05_12515	COG0671	phosphoesterase, PA-phosphatase related
AOC05_12520	COG0586	Pfam SNARE associated Golgi protein
AOC05_12525	COG0745	RESPONSE REGULATOR receiver
AOC05_12530	COG5002	protein histidine kinase activity
AOC05_12535	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AOC05_12550	COG0802	atpase or kinase
AOC05_12555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AOC05_12560	COG0438	transferase activity, transferring glycosyl groups
AOC05_12570	COG0366	Alpha amylase catalytic
AOC05_12580	COG1260	myo-inositol-1-phosphate synthase
AOC05_12585	COG0667	Aldo Keto reductase
AOC05_12600	COG0736	holo-[acyl-carrier-protein] synthase activity
AOC05_12605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AOC05_12610	COG1072	(Pantothenic acid kinase))
AOC05_12620	COG1970	mechanosensitive ion channel activity
AOC05_12625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOC05_12630	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AOC05_12635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AOC05_12640	COG0101	tRNA pseudouridine synthase activity
AOC05_12645	COG0203	ribosomal protein L17
AOC05_12650	COG0202	RNA polymerase activity
AOC05_12655	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AOC05_12660	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AOC05_12665	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AOC05_12670	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AOC05_12675	COG3191	aminopeptidase activity
AOC05_12685	COG0395	ABC-type sugar transport system, permease component
AOC05_12690	COG1175	transmembrane transport
AOC05_12695	COG0584	glycerophosphoryl diester phosphodiesterase
AOC05_12700	COG0024	Methionine aminopeptidase
AOC05_12705	COG0563	adenylate kinase activity
AOC05_12715	COG0200	Binds to the 23S rRNA
AOC05_12720	COG1841	ribosomal large subunit assembly
AOC05_12725	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AOC05_12735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AOC05_12740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AOC05_12745	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AOC05_12750	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AOC05_12755	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AOC05_12760	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AOC05_12765	COG0255	Belongs to the universal ribosomal protein uL29 family
AOC05_12770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AOC05_12775	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AOC05_12780	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AOC05_12785	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AOC05_12790	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AOC05_12795	COG0089	rRNA binding
AOC05_12800	COG0088	Forms part of the polypeptide exit tunnel
AOC05_12805	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AOC05_12810	COG0051	transcription antitermination factor activity, RNA binding
AOC05_12835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AOC05_12840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AOC05_12845	COG0049	tRNA binding
AOC05_12850	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AOC05_12855	COG1752	Esterase of the alpha-beta hydrolase superfamily
AOC05_12860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AOC05_12865	COG0085	RNA polymerase activity
AOC05_12870	COG0183	Belongs to the thiolase family
AOC05_12875	COG0222	ribosome binding
AOC05_12880	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AOC05_12895	COG0081	regulation of translation
AOC05_12900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AOC05_12905	COG0250	Participates in transcription elongation, termination and antitermination
AOC05_12920	COG0436	Aminotransferase
AOC05_12925	COG2197	response regulator
AOC05_12965	COG0354	folic acid binding
AOC05_12970	COG3485	protocatechuate 3,4-dioxygenase
AOC05_12980	COG0745	RESPONSE REGULATOR receiver
AOC05_12985	COG0456	acetyltransferase
AOC05_12990	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AOC05_13010	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AOC05_13015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AOC05_13035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AOC05_13050	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AOC05_13055	COG0738	Major facilitator superfamily
AOC05_13060	COG2030	dehydratase
AOC05_13065	COG2030	dehydratase
AOC05_13075	COG0477	Major facilitator Superfamily
AOC05_13090	COG2301	Belongs to the HpcH HpaI aldolase family
AOC05_13105	COG0025	NhaP-type Na H and K H
AOC05_13135	COG0477	Major facilitator Superfamily
AOC05_13155	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AOC05_13165	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AOC05_13175	COG0402	S-adenosylhomocysteine deaminase activity
AOC05_13180	COG2801	Transposase and inactivated derivatives
AOC05_13190	COG1652	LysM domain
AOC05_13205	COG4977	sequence-specific DNA binding
AOC05_13245	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AOC05_13260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AOC05_13265	COG2814	Major facilitator Superfamily
AOC05_13275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AOC05_13300	COG1666	GTP binding
AOC05_13310	COG2197	response regulator
AOC05_13315	COG4585	Histidine kinase
AOC05_13320	COG0406	alpha-ribazole phosphatase activity
AOC05_13325	COG0501	Belongs to the peptidase M48B family
AOC05_13340	COG0753	catalase activity
AOC05_13370	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AOC05_13375	COG0531	amino acid
AOC05_13400	COG0673	inositol 2-dehydrogenase activity
AOC05_13415	COG1012	belongs to the aldehyde dehydrogenase family
AOC05_13435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AOC05_13435	COG1648	precorrin-2 dehydrogenase activity
AOC05_13440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOC05_13445	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AOC05_13500	COG0175	sulfate reduction
AOC05_13505	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOC05_13525	COG4152	abc transporter atp-binding protein
AOC05_13530	COG2860	membrane
AOC05_13565	COG2226	methyltransferase
AOC05_13570	COG1169	isochorismate synthase
AOC05_13580	COG0765	amino acid transport
AOC05_13585	COG1126	abc transporter atp-binding protein
AOC05_13590	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AOC05_13595	COG4948	Mandelate Racemase Muconate Lactonizing
AOC05_13610	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOC05_13625	COG1522	sequence-specific DNA binding
AOC05_13630	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AOC05_13645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOC05_13650	COG2151	metal-sulfur cluster biosynthetic enzyme
AOC05_13655	COG3396	Phenylacetate-CoA oxygenase
AOC05_13660	COG3460	Phenylacetate-CoA oxygenase
AOC05_13665	COG3396	Phenylacetate-CoA oxygenase
AOC05_13670	COG2050	protein possibly involved in aromatic compounds catabolism
AOC05_13700	COG1012	belongs to the aldehyde dehydrogenase family
AOC05_13700	COG2030	dehydratase
AOC05_13705	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOC05_13710	COG1024	Enoyl-CoA hydratase
AOC05_13730	COG2211	Major facilitator Superfamily
AOC05_13735	COG0076	glutamate decarboxylase activity
AOC05_13740	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AOC05_13745	COG0857	belongs to the CobB CobQ family
AOC05_13745	COG0280	phosphate acetyltransferase
AOC05_13790	COG0653	protein targeting
AOC05_13805	COG2365	Tyrosine phosphatase family
AOC05_13815	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AOC05_13850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AOC05_13855	COG1333	cytochrome c biogenesis protein
AOC05_13860	COG0785	Cytochrome C biogenesis protein
AOC05_13865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AOC05_13870	COG0406	alpha-ribazole phosphatase activity
AOC05_13885	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AOC05_13895	COG0560	Phosphoserine phosphatase
AOC05_13910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AOC05_13915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOC05_13920	COG1070	Carbohydrate kinase
AOC05_13925	COG1028	Short-chain dehydrogenase reductase Sdr
AOC05_13925	COG3347	Dehydrogenase
AOC05_13935	COG3254	rhamnose metabolic process
AOC05_13955	COG1172	Belongs to the binding-protein-dependent transport system permease family
AOC05_13960	COG1129	ABC transporter
AOC05_13965	COG1609	Transcriptional regulator
AOC05_13970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AOC05_13975	COG0640	Transcriptional regulator
AOC05_13980	COG0123	including yeast histone deacetylase and acetoin utilization protein
AOC05_13985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AOC05_13990	COG0569	domain protein
AOC05_13995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AOC05_14000	COG1595	DNA-templated transcription, initiation
AOC05_14005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AOC05_14005	COG2169	Transcriptional regulator
AOC05_14010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AOC05_14015	COG1082	Xylose isomerase domain protein TIM barrel
AOC05_14020	COG0248	Ppx GppA phosphatase
AOC05_14025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AOC05_14025	COG1754	DNA topoisomerase type I activity
AOC05_14035	COG2890	protein-(glutamine-N5) methyltransferase activity
AOC05_14050	COG1111	helicase
AOC05_14050	COG1205	dead DEAH box helicase
AOC05_14115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOC05_14120	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AOC05_14145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AOC05_14150	COG1408	metallophosphoesterase
AOC05_14155	COG1132	(ABC) transporter
AOC05_14160	COG1132	(ABC) transporter
AOC05_14170	COG2824	Alkylphosphonate utilization operon protein PhnA
AOC05_14185	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AOC05_14190	COG0151	Belongs to the GarS family
AOC05_14220	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AOC05_14235	COG0542	response to heat
AOC05_14240	COG1063	alcohol dehydrogenase
AOC05_14250	COG2226	methyltransferase
AOC05_14285	COG3304	Inner membrane component domain
AOC05_14325	COG0475	glutathione-regulated potassium exporter activity
AOC05_14325	COG0569	domain protein
AOC05_14335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AOC05_14345	COG1140	nitrate reductase beta subunit
AOC05_14365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AOC05_14370	COG0789	Transcriptional regulator
AOC05_14375	COG0484	heat shock protein binding
AOC05_14380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AOC05_14385	COG0443	Heat shock 70 kDa protein
AOC05_14400	COG1280	lysine exporter protein (LysE YggA)
AOC05_14405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AOC05_14415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOC05_14430	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AOC05_14435	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AOC05_14475	COG1122	ATPase activity
AOC05_14480	COG4721	ABC-type cobalt transport system, permease component
AOC05_14490	COG1320	monovalent cation:proton antiporter activity
AOC05_14495	COG2212	antiporter activity
AOC05_14515	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AOC05_14515	COG2111	Na H antiporter
AOC05_14525	COG0717	Belongs to the dCTP deaminase family
AOC05_14535	COG0475	glutathione-regulated potassium exporter activity
AOC05_14570	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AOC05_14590	COG0433	COG0433 Predicted ATPase
AOC05_14605	COG1276	copper resistance
AOC05_14605	COG2372	response to copper ion
AOC05_14610	COG0776	regulation of translation
AOC05_14615	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AOC05_14620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AOC05_14625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AOC05_14645	COG1132	(ABC) transporter
AOC05_14655	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AOC05_14660	COG2764	glyoxalase bleomycin resistance protein dioxygenase
AOC05_14675	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AOC05_14680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AOC05_14690	COG0435	Glutathione S-transferase
AOC05_14695	COG1125	glycine betaine transport
AOC05_14695	COG0517	IMP dehydrogenase activity
AOC05_14700	COG1174	glycine betaine transport
AOC05_14705	COG1174	glycine betaine transport
AOC05_14770	COG1028	Short-chain dehydrogenase reductase Sdr
AOC05_14845	COG0745	RESPONSE REGULATOR receiver
AOC05_14870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AOC05_14875	COG1120	ATPase activity
AOC05_14895	COG0673	inositol 2-dehydrogenase activity
AOC05_14915	COG0686	Belongs to the AlaDH PNT family
AOC05_14930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOC05_14950	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOC05_14955	COG0022	dehydrogenase e1 component
AOC05_14965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AOC05_14970	COG1950	PFAM Membrane protein of
AOC05_14985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AOC05_15000	COG1607	acyl-coa hydrolase
AOC05_15025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AOC05_15035	COG0028	Belongs to the TPP enzyme family
AOC05_15045	COG2213	PTS system mannitol-specific
AOC05_15055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AOC05_15065	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AOC05_15075	COG1937	Protein conserved in bacteria
AOC05_15105	COG4209	transmembrane transport
AOC05_15115	COG4821	SIS domain
AOC05_15160	COG0359	binds to the 23S rRNA
AOC05_15165	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AOC05_15175	COG0360	Binds together with S18 to 16S ribosomal RNA
AOC05_15190	COG1362	aminopeptidase activity
AOC05_15195	COG2197	response regulator
AOC05_15200	COG4585	Histidine kinase
AOC05_15220	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOC05_15230	COG0738	Major facilitator superfamily
AOC05_15235	COG0488	(ABC) transporter
AOC05_15245	COG2197	response regulator
AOC05_15265	COG0577	efflux transmembrane transporter activity
AOC05_15295	COG0406	alpha-ribazole phosphatase activity
AOC05_15320	COG0492	ferredoxin-NADP+ reductase activity
AOC05_15325	COG3118	belongs to the thioredoxin family
AOC05_15340	COG3547	Transposase (IS116 IS110 IS902 family)
AOC05_15345	COG3547	Transposase (IS116 IS110 IS902 family)
AOC05_15350	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AOC05_15365	COG1192	Involved in chromosome partitioning
AOC05_15370	COG0357	Ribosomal RNA small subunit methyltransferase G
AOC05_15380	COG0706	membrane insertase activity
AOC05_15385	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AOC05_15390	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AOC05_15395	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AOC05_15405	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AOC05_15410	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AOC05_15415	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AOC05_15420	COG0187	DNA topoisomerase II activity
AOC05_15425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AOC05_15430	COG3266	domain, Protein
AOC05_15460	COG0705	Rhomboid family
AOC05_15495	COG0596	Alpha beta hydrolase
AOC05_15505	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AOC05_15520	COG3764	Sortase (surface protein transpeptidase)
AOC05_15530	COG0515	serine threonine protein kinase
AOC05_15535	COG0515	serine threonine protein kinase
AOC05_15540	COG0768	penicillin binding
AOC05_15555	COG1716	ATPase activity
AOC05_15560	COG1716	ATPase activity
AOC05_15570	COG2826	transposase and inactivated derivatives, IS30 family
AOC05_15610	COG2801	Transposase and inactivated derivatives
AOC05_15715	COG3853	Toxic anion resistance protein (TelA)
AOC05_15750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AOC05_15760	COG1522	sequence-specific DNA binding
AOC05_15765	COG0247	lactate metabolic process
AOC05_15770	COG1139	Iron-sulfur cluster binding protein
AOC05_15775	COG1556	Lactate utilization protein
AOC05_15795	COG1063	alcohol dehydrogenase
AOC05_15810	COG4786	Flagellar basal body rod
AOC05_15810	COG1256	bacterial-type flagellum assembly
AOC05_15825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AOC05_15845	COG1815	bacterial-type flagellum-dependent cell motility
AOC05_15850	COG1558	bacterial-type flagellum-dependent cell motility
AOC05_15855	COG1677	Flagellar hook-basal body complex protein FliE
AOC05_15875	COG1157	protein secretion by the type III secretion system
AOC05_15890	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AOC05_15930	COG1338	Plays a role in the flagellum-specific transport system
AOC05_15935	COG1987	bacterial-type flagellum assembly
AOC05_15945	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AOC05_15950	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AOC05_15960	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AOC05_16020	COG2409	Drug exporters of the RND superfamily
AOC05_16025	COG0006	proline dipeptidase activity
AOC05_16035	COG0559	Belongs to the binding-protein-dependent transport system permease family
AOC05_16050	COG0410	ABC transporter
AOC05_16055	COG3938	Belongs to the proline racemase family
AOC05_16070	COG2197	response regulator
AOC05_16085	COG3938	Belongs to the proline racemase family
AOC05_16105	COG1802	Transcriptional regulator
AOC05_16145	COG0561	phosphatase activity
AOC05_16155	COG1929	Belongs to the glycerate kinase type-1 family
AOC05_16160	COG2233	PERMEase
AOC05_16190	COG3104	oligopeptide transport
AOC05_16195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AOC05_16205	COG1597	lipid kinase activity
AOC05_16210	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AOC05_16215	COG0561	phosphatase activity
AOC05_16260	COG0037	tRNA processing
AOC05_16270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOC05_16275	COG0302	gtp cyclohydrolase
AOC05_16285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AOC05_16315	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AOC05_16320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOC05_16325	COG0477	Major facilitator Superfamily
AOC05_16335	COG1609	Transcriptional regulator
AOC05_16340	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AOC05_16350	COG0542	response to heat
AOC05_16360	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AOC05_16365	COG2376	Dihydroxyacetone kinase
AOC05_16370	COG1461	Dihydroxyacetone kinase
AOC05_16375	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AOC05_16375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOC05_16375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AOC05_16390	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AOC05_16410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AOC05_16425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AOC05_16460	COG1335	isochorismatase
AOC05_16465	COG0351	phosphomethylpyrimidine kinase
AOC05_16475	COG4221	oxidoreductase activity
AOC05_16485	COG0477	Major facilitator Superfamily
AOC05_16490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOC05_16490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOC05_16490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOC05_16495	COG1105	Belongs to the carbohydrate kinase PfkB family
AOC05_16500	COG1349	DNA-binding transcription factor activity
AOC05_16520	COG2733	membrane
AOC05_16525	COG0584	glycerophosphoryl diester phosphodiesterase
AOC05_16560	COG4122	O-methyltransferase activity
AOC05_16610	COG0010	Belongs to the arginase family
AOC05_16615	COG2252	PERMEase
AOC05_16620	COG2372	response to copper ion
AOC05_16645	COG3883	PFAM NLP P60 protein
AOC05_16645	COG0791	NLP P60 protein
AOC05_16740	COG4175	Glycine betaine
AOC05_16740	COG0517	IMP dehydrogenase activity
AOC05_16745	COG4176	ABC-type proline glycine betaine transport system permease component
AOC05_16760	COG2801	Transposase and inactivated derivatives
AOC05_16765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOC05_16770	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AOC05_16785	COG1175	transmembrane transport
AOC05_16790	COG0395	ABC-type sugar transport system, permease component
AOC05_16795	COG4948	Mandelate Racemase Muconate Lactonizing
AOC05_16810	COG4948	Mandelate Racemase Muconate Lactonizing
AOC05_16815	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AOC05_16820	COG1435	thymidine kinase activity
AOC05_16840	COG0191	fructose-bisphosphate aldolase activity
AOC05_16870	COG0477	Major facilitator Superfamily
AOC05_16885	COG1028	Short-chain dehydrogenase reductase Sdr
AOC05_16890	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AOC05_16895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOC05_16905	COG1832	CoA-binding protein
AOC05_16930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AOC05_16935	COG0047	phosphoribosylformylglycinamidine synthase activity
AOC05_16940	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AOC05_16950	COG1846	Transcriptional regulator
AOC05_16975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOC05_16980	COG2076	Multidrug Resistance protein
AOC05_16990	COG1012	belongs to the aldehyde dehydrogenase family
AOC05_17005	COG4555	ABC transporter
AOC05_17015	COG0129	dihydroxy-acid dehydratase activity
AOC05_17025	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AOC05_17045	COG0386	Belongs to the glutathione peroxidase family
AOC05_17065	COG1309	transcriptional regulator
AOC05_17115	COG4942	peptidase
AOC05_17120	COG4565	transcriptional regulatory protein
AOC05_17125	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AOC05_17145	COG0488	(ABC) transporter
AOC05_17165	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AOC05_17180	COG1132	(ABC) transporter
AOC05_17185	COG1132	(ABC) transporter
AOC05_17190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOC05_17205	COG0673	inositol 2-dehydrogenase activity
AOC05_17210	COG0673	inositol 2-dehydrogenase activity
AOC05_17225	COG1609	Transcriptional regulator
AOC05_17235	COG1175	transmembrane transport
AOC05_17240	COG0395	ABC-type sugar transport system, permease component
AOC05_17260	COG0492	ferredoxin-NADP+ reductase activity
AOC05_17260	COG3118	belongs to the thioredoxin family
AOC05_17275	COG1136	(ABC) transporter
AOC05_17290	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AOC05_17300	COG1192	Involved in chromosome partitioning
AOC05_17345	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AOC05_17380	COG0477	Major facilitator Superfamily
AOC05_17385	COG1028	Short-chain dehydrogenase reductase Sdr
AOC05_17395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AOC05_17420	COG1476	TRANSCRIPTIONal
AOC05_17435	COG1960	acyl-CoA dehydrogenase activity
AOC05_17470	COG3971	2-oxopent-4-enoate hydratase activity
AOC05_17480	COG1012	belongs to the aldehyde dehydrogenase family
AOC05_17485	COG1802	Transcriptional regulator
AOC05_17495	COG1522	sequence-specific DNA binding
AOC05_17500	COG0028	Belongs to the TPP enzyme family
AOC05_17525	COG3226	Transcriptional regulator
AOC05_17540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AOC05_17575	COG3483	tryptophan 2,3-dioxygenase activity
AOC05_17590	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AOC05_17590	COG1473	amidohydrolase
AOC05_17595	COG1737	Transcriptional regulator
AOC05_17610	COG0343	queuine tRNA-ribosyltransferase activity
AOC05_17640	COG0601	transmembrane transport
AOC05_17650	COG4172	Belongs to the ABC transporter superfamily
AOC05_17660	COG1028	Short-chain dehydrogenase reductase Sdr
AOC05_17665	COG1012	belongs to the aldehyde dehydrogenase family
AOC05_17670	COG0473	3-isopropylmalate dehydrogenase activity
AOC05_17705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AOC05_17715	COG1302	Protein conserved in bacteria
AOC05_17755	COG0564	pseudouridine synthase activity
AOC05_17775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AOC05_17780	COG1201	RNA secondary structure unwinding
AOC05_17810	COG0745	RESPONSE REGULATOR receiver
AOC05_17870	COG3177	Filamentation induced by cAMP protein fic
AOC05_17890	COG3177	Filamentation induced by cAMP protein fic
AOC05_17930	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AOC05_17935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AOC05_18025	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AOC05_18125	COG1028	Short-chain dehydrogenase reductase Sdr
AOC05_18135	COG0783	Belongs to the Dps family
AOC05_18210	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AOC05_18235	COG2062	phosphohistidine phosphatase, SixA
AOC05_18240	COG1511	domain protein
AOC05_18255	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AOC05_18260	COG1940	carbohydrate kinase activity
AOC05_18270	COG4608	Belongs to the ABC transporter superfamily
AOC05_18275	COG0444	Belongs to the ABC transporter superfamily
AOC05_18290	COG2186	Transcriptional regulator
AOC05_18305	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AOC05_18315	COG1959	2 iron, 2 sulfur cluster binding
AOC05_18330	COG0514	ATP-dependent DNA helicase (RecQ)
AOC05_18335	COG1028	Short-chain dehydrogenase reductase Sdr
AOC05_18345	COG4948	Mandelate Racemase Muconate Lactonizing
AOC05_18375	COG1172	Belongs to the binding-protein-dependent transport system permease family
AOC05_18380	COG1879	ABC-type sugar transport system periplasmic component
AOC05_18385	COG2186	Transcriptional regulator
AOC05_18395	COG1505	serine-type exopeptidase activity
AOC05_18415	COG1966	Carbon starvation protein
AOC05_18445	COG3842	ATPase activity
AOC05_18465	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AOC05_18470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AOC05_18475	COG0626	cystathionine gamma-synthase activity
AOC05_18490	COG0831	urea catabolic process