locus-tag	class	description
HPK19_00010	COG0667	Aldo Keto reductase
HPK19_00020	COG1942	4-Oxalocrotonate Tautomerase
HPK19_00030	COG0583	DNA-binding transcription factor activity
HPK19_00035	COG4122	O-methyltransferase activity
HPK19_00055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPK19_00085	COG0456	acetyltransferase
HPK19_00105	COG1131	(ABC) transporter
HPK19_00115	COG1376	ErfK ybiS ycfS ynhG family protein
HPK19_00135	COG3069	C4-dicarboxylate transmembrane transporter activity
HPK19_00140	COG0494	nUDIX hydrolase
HPK19_00145	COG1792	Involved in formation and maintenance of cell shape
HPK19_00150	COG2205	protein histidine kinase activity
HPK19_00150	COG0784	Response regulator, receiver
HPK19_00190	COG0494	nUDIX hydrolase
HPK19_00210	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HPK19_00245	COG1404	Belongs to the peptidase S8 family
HPK19_00265	COG0658	competence protein
HPK19_00265	COG2333	competence protein COMEC
HPK19_00290	COG1131	(ABC) transporter
HPK19_00300	COG0765	amino acid transport
HPK19_00305	COG0765	amino acid transport
HPK19_00310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK19_00315	COG1126	abc transporter atp-binding protein
HPK19_00330	COG1404	Belongs to the peptidase S8 family
HPK19_00390	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_00415	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HPK19_00420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK19_00420	COG1263	PTS System
HPK19_00430	COG1737	Transcriptional regulator
HPK19_00465	COG0395	ABC-type sugar transport system, permease component
HPK19_00475	COG0673	inositol 2-dehydrogenase activity
HPK19_00480	COG1082	Xylose isomerase domain protein TIM barrel
HPK19_00490	COG3962	Belongs to the TPP enzyme family
HPK19_00495	COG3718	enzyme involved in inositol metabolism
HPK19_00500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK19_00505	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_00510	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPK19_00515	COG2723	6-phospho-beta-galactosidase activity
HPK19_00520	COG1414	Transcriptional regulator
HPK19_00525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK19_00530	COG0800	Aldolase
HPK19_00535	COG4948	Mandelate Racemase Muconate Lactonizing
HPK19_00540	COG2271	Major facilitator Superfamily
HPK19_00555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK19_00560	COG4209	transmembrane transport
HPK19_00565	COG0395	ABC-type sugar transport system, permease component
HPK19_00605	COG1131	(ABC) transporter
HPK19_00610	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPK19_00635	COG4251	negative regulation of phosphorylation
HPK19_00635	COG5001	Diguanylate cyclase
HPK19_00635	COG3706	GGDEF domain
HPK19_00635	COG2203	Gaf domain
HPK19_00645	COG1388	LysM domain
HPK19_00645	COG0791	NLP P60 protein
HPK19_00660	COG1388	LysM domain
HPK19_00660	COG3584	3D domain protein
HPK19_00670	COG3383	formate dehydrogenase (NAD+) activity
HPK19_00675	COG2427	Protein of unknown function (DUF1641)
HPK19_00680	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPK19_00690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPK19_00695	COG0303	'Molybdopterin
HPK19_00700	COG0314	molybdopterin synthase activity
HPK19_00705	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPK19_00715	COG0746	molybdenum cofactor guanylyltransferase activity
HPK19_00725	COG5609	conserved protein (DUF2294)
HPK19_00730	COG1763	Mo-molybdopterin cofactor biosynthetic process
HPK19_00735	COG4149	molybdate abc transporter
HPK19_00740	COG2258	MOSC domain
HPK19_00760	COG1073	alpha beta
HPK19_00785	COG1653	transport
HPK19_00790	COG1175	transmembrane transport
HPK19_00795	COG0395	ABC-type sugar transport system, permease component
HPK19_00800	COG0366	Alpha amylase catalytic
HPK19_00810	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HPK19_00820	COG1940	carbohydrate kinase activity
HPK19_00825	COG1482	cell wall glycoprotein biosynthetic process
HPK19_00855	COG1794	racemase activity, acting on amino acids and derivatives
HPK19_00865	COG4585	Histidine kinase
HPK19_00870	COG2197	response regulator
HPK19_00880	COG1011	Hydrolase
HPK19_00890	COG1396	sequence-specific DNA binding
HPK19_00910	COG2267	carboxylic ester hydrolase activity
HPK19_00915	COG1472	Belongs to the glycosyl hydrolase 3 family
HPK19_00945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPK19_00955	COG1959	2 iron, 2 sulfur cluster binding
HPK19_00965	COG2514	catechol 2,3-dioxygenase activity
HPK19_00975	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HPK19_01025	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPK19_01035	COG1610	YqeY-like protein
HPK19_01050	COG1702	phosphate starvation-inducible protein PhoH
HPK19_01055	COG1480	7TM receptor with intracellular HD hydrolase
HPK19_01060	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPK19_01065	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPK19_01070	COG0295	cytidine deaminase activity
HPK19_01075	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPK19_01085	COG1381	Involved in DNA repair and RecF pathway recombination
HPK19_01090	COG0517	IMP dehydrogenase activity
HPK19_01095	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPK19_01100	COG0358	DNA primase activity
HPK19_01105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPK19_01110	COG2010	Cytochrome c
HPK19_01115	COG2384	SAM-dependent methyltransferase
HPK19_01120	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPK19_01125	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPK19_01140	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPK19_01165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPK19_01170	COG1121	(ABC) transporter
HPK19_01175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPK19_01180	COG0735	belongs to the Fur family
HPK19_01190	COG0300	oxidoreductase activity
HPK19_01205	COG4187	Peptidase family M20/M25/M40
HPK19_01220	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HPK19_01230	COG4208	sulfate ABC transporter
HPK19_01240	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPK19_01270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPK19_01280	COG0477	Major facilitator Superfamily
HPK19_01295	COG0704	Plays a role in the regulation of phosphate uptake
HPK19_01305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPK19_01310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPK19_01320	COG1876	peptidase activity
HPK19_01330	COG1940	carbohydrate kinase activity
HPK19_01335	COG1368	sulfuric ester hydrolase activity
HPK19_01350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_01365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPK19_01370	COG1459	type II secretion system
HPK19_01375	COG4537	Required for transformation and DNA binding
HPK19_01400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPK19_01415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPK19_01420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPK19_01425	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPK19_01435	COG0737	Belongs to the 5'-nucleotidase family
HPK19_01435	COG1525	nuclease
HPK19_01435	COG4085	toxin activity
HPK19_01445	COG0745	RESPONSE REGULATOR receiver
HPK19_01450	COG5002	protein histidine kinase activity
HPK19_01455	COG0527	aspartate kinase activity
HPK19_01460	COG1522	sequence-specific DNA binding
HPK19_01465	COG0436	Aminotransferase
HPK19_01485	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPK19_01490	COG0529	Catalyzes the synthesis of activated sulfate
HPK19_01495	COG2046	Belongs to the sulfate adenylyltransferase family
HPK19_01500	COG0175	sulfate reduction
HPK19_01510	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HPK19_01515	COG2409	Drug exporters of the RND superfamily
HPK19_01520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPK19_01525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK19_01530	COG0095	Lipoate-protein ligase
HPK19_01550	COG3872	metal-dependent enzyme
HPK19_01560	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPK19_01565	COG0006	proline dipeptidase activity
HPK19_01570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPK19_01585	COG3854	ATPases associated with a variety of cellular activities
HPK19_01625	COG0511	ligase activity, forming carbon-carbon bonds
HPK19_01630	COG0439	Biotin carboxylase
HPK19_01635	COG1302	Protein conserved in bacteria
HPK19_01640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK19_01645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPK19_01650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPK19_01655	COG1570	exodeoxyribonuclease VII activity
HPK19_01660	COG1722	exodeoxyribonuclease VII activity
HPK19_01670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPK19_01675	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HPK19_01680	COG1438	arginine binding
HPK19_01685	COG0497	DNA recombination
HPK19_01690	COG0750	zinc metalloprotease
HPK19_01695	COG0745	RESPONSE REGULATOR receiver
HPK19_01705	COG3093	addiction module antidote protein HigA
HPK19_01710	COG0584	glycerophosphoryl diester phosphodiesterase
HPK19_01720	COG3290	protein histidine kinase activity
HPK19_01720	COG3829	transcription factor binding
HPK19_01725	COG0280	phosphate acetyltransferase
HPK19_01735	COG3426	butyrate kinase activity
HPK19_01740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPK19_01745	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPK19_01750	COG0022	dehydrogenase e1 component
HPK19_01755	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPK19_01765	COG2211	Major facilitator Superfamily
HPK19_01790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK19_01800	COG0765	amino acid transport
HPK19_01805	COG1126	abc transporter atp-binding protein
HPK19_01810	COG1607	acyl-coa hydrolase
HPK19_01815	COG4129	membrane
HPK19_01820	COG1376	ErfK ybiS ycfS ynhG family protein
HPK19_01830	COG0346	lactoylglutathione lyase activity
HPK19_01835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPK19_01840	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPK19_01845	COG0586	Pfam SNARE associated Golgi protein
HPK19_01865	COG3011	Protein conserved in bacteria
HPK19_01870	COG2346	COG2346, Truncated hemoglobins
HPK19_01890	COG0405	Gamma-glutamyltransferase
HPK19_01895	COG2059	Chromate
HPK19_01900	COG2059	Chromate
HPK19_01915	COG0789	Transcriptional regulator
HPK19_01920	COG0492	ferredoxin-NADP+ reductase activity
HPK19_01925	COG0697	spore germination
HPK19_01930	COG3708	Transcriptional regulator
HPK19_01930	COG2207	Transcriptional regulator
HPK19_01935	COG0673	inositol 2-dehydrogenase activity
HPK19_01945	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HPK19_01960	COG1234	tRNA 3'-trailer cleavage
HPK19_01995	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPK19_02000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_02005	COG0300	oxidoreductase activity
HPK19_02015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPK19_02035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPK19_02040	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPK19_02045	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPK19_02050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPK19_02055	COG0748	coenzyme F420 binding
HPK19_02085	COG4948	Mandelate Racemase Muconate Lactonizing
HPK19_02090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPK19_02095	COG0747	negative chemotaxis
HPK19_02110	COG0444	Belongs to the ABC transporter superfamily
HPK19_02115	COG4608	Belongs to the ABC transporter superfamily
HPK19_02120	COG4946	Tricorn protease homolog
HPK19_02120	COG1506	peptidase
HPK19_02120	COG0823	Involved in the tonB-independent uptake of proteins
HPK19_02125	COG1473	amidohydrolase
HPK19_02130	COG3402	PFAM membrane-flanked domain
HPK19_02135	COG3428	Bacterial PH domain
HPK19_02140	COG0277	FAD linked oxidase domain protein
HPK19_02145	COG2271	Major facilitator Superfamily
HPK19_02155	COG2814	Major facilitator Superfamily
HPK19_02160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPK19_02170	COG0778	Nitroreductase
HPK19_02175	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HPK19_02185	COG0351	phosphomethylpyrimidine kinase
HPK19_02190	COG0833	amino acid
HPK19_02200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_02215	COG0604	alcohol dehydrogenase
HPK19_02220	COG2197	response regulator
HPK19_02230	COG1131	(ABC) transporter
HPK19_02235	COG0842	Transport permease protein
HPK19_02260	COG2207	Transcriptional regulator
HPK19_02265	COG0346	lactoylglutathione lyase activity
HPK19_02275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HPK19_02290	COG0805	protein transport
HPK19_02310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPK19_02330	COG0561	phosphatase activity
HPK19_02365	COG1979	alcohol dehydrogenase
HPK19_02370	COG1073	alpha beta
HPK19_02390	COG2368	4-hydroxyphenylacetate
HPK19_02410	COG0251	oxidation-reduction process
HPK19_02445	COG2814	Major facilitator Superfamily
HPK19_02455	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPK19_02455	COG0456	acetyltransferase
HPK19_02460	COG0667	Aldo Keto reductase
HPK19_02485	COG1300	Membrane
HPK19_02490	COG0735	belongs to the Fur family
HPK19_02500	COG4974	Belongs to the 'phage' integrase family
HPK19_02505	COG0024	Methionine aminopeptidase
HPK19_02510	COG0861	Integral membrane protein TerC family
HPK19_02515	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPK19_02520	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HPK19_02545	COG1131	(ABC) transporter
HPK19_02550	COG1725	Transcriptional regulator
HPK19_02555	COG1686	Belongs to the peptidase S11 family
HPK19_02565	COG2172	sigma factor antagonist activity
HPK19_02570	COG1191	sigma factor activity
HPK19_02590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPK19_02605	COG0697	spore germination
HPK19_02610	COG4086	secreted protein
HPK19_02615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPK19_02630	COG1547	Domain of unknown function (DUF309)
HPK19_02640	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HPK19_02645	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HPK19_02660	COG4129	membrane
HPK19_02665	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPK19_02670	COG1686	Belongs to the peptidase S11 family
HPK19_02675	COG2715	membrane protein required for spore maturation
HPK19_02680	COG0700	Nucleoside recognition
HPK19_02685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPK19_02690	COG0626	cystathionine gamma-synthase activity
HPK19_02695	COG2226	methyltransferase
HPK19_02700	COG1854	S-ribosylhomocysteine lyase activity
HPK19_02715	COG1187	pseudouridine synthase activity
HPK19_02725	COG1333	cytochrome c biogenesis protein
HPK19_02730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPK19_02735	COG0745	RESPONSE REGULATOR receiver
HPK19_02740	COG5002	protein histidine kinase activity
HPK19_02745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPK19_02750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK19_02755	COG1120	ATPase activity
HPK19_02760	COG2096	Adenosyltransferase
HPK19_02775	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HPK19_02790	COG0514	ATP-dependent DNA helicase (RecQ)
HPK19_02820	COG4862	establishment of competence for transformation
HPK19_02825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPK19_02830	COG0492	ferredoxin-NADP+ reductase activity
HPK19_02845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPK19_02865	COG1160	GTP binding
HPK19_02870	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPK19_02890	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPK19_02895	COG0776	regulation of translation
HPK19_02900	COG0302	gtp cyclohydrolase
HPK19_02905	COG0142	geranyltranstransferase activity
HPK19_02910	COG2226	methyltransferase
HPK19_02915	COG0142	geranyltranstransferase activity
HPK19_02920	COG0105	UTP biosynthetic process
HPK19_02930	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPK19_02935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HPK19_02940	COG0457	Tetratricopeptide repeat
HPK19_02945	COG5582	Belongs to the UPF0302 family
HPK19_02960	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPK19_02970	COG4347	Protein of unknown function (DUF1405)
HPK19_02980	COG2738	Putative neutral zinc metallopeptidase
HPK19_02985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPK19_02990	COG1694	Mazg nucleotide pyrophosphohydrolase
HPK19_03005	COG0438	transferase activity, transferring glycosyl groups
HPK19_03010	COG0617	tRNA 3'-terminal CCA addition
HPK19_03015	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HPK19_03015	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HPK19_03020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPK19_03025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPK19_03035	COG1199	ATP-dependent helicase activity
HPK19_03035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPK19_03055	COG3935	DnaD domain protein
HPK19_03060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPK19_03070	COG4499	WXG100 protein secretion system (Wss), protein YukC
HPK19_03070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPK19_03100	COG2188	Transcriptional regulator
HPK19_03105	COG4474	Belongs to the UPF0398 family
HPK19_03120	COG0116	Belongs to the methyltransferase superfamily
HPK19_03125	COG0582	viral genome integration into host DNA
HPK19_03210	COG0740	serine-type endopeptidase activity
HPK19_03355	COG1674	ftsk spoiiie
HPK19_03385	COG3655	Transcriptional regulator
HPK19_03400	COG0673	inositol 2-dehydrogenase activity
HPK19_03405	COG1199	ATP-dependent helicase activity
HPK19_03435	COG0702	epimerase
HPK19_03440	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPK19_03460	COG0640	Transcriptional regulator
HPK19_03465	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPK19_03470	COG3424	synthase
HPK19_03475	COG1755	Isoprenylcysteine carboxyl methyltransferase
HPK19_03480	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPK19_03500	COG0328	RNA-DNA hybrid ribonuclease activity
HPK19_03505	COG0328	RNA-DNA hybrid ribonuclease activity
HPK19_03545	COG3949	Membrane
HPK19_03555	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPK19_03560	COG1183	phosphatidylcholine synthase activity
HPK19_03565	COG4166	transmembrane transport
HPK19_03570	COG4166	transmembrane transport
HPK19_03575	COG0586	Pfam SNARE associated Golgi protein
HPK19_03590	COG0701	Predicted permease
HPK19_03595	COG3689	TIGRFAM TIGR03943 family protein
HPK19_03605	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPK19_03640	COG1132	(ABC) transporter
HPK19_03660	COG0386	Belongs to the glutathione peroxidase family
HPK19_03665	COG1418	mRNA catabolic process
HPK19_03670	COG0488	(ABC) transporter
HPK19_03680	COG1413	lyase activity
HPK19_03690	COG2521	methyltransferase
HPK19_03690	COG2136	Putative SAM-dependent methyltransferase
HPK19_03705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPK19_03710	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HPK19_03720	COG1272	protein, Hemolysin III
HPK19_03725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPK19_03735	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPK19_03740	COG1307	EDD domain protein, DegV family
HPK19_03750	COG1999	signal sequence binding
HPK19_03760	COG1247	-acetyltransferase
HPK19_03785	COG0789	Transcriptional regulator
HPK19_03790	COG1253	flavin adenine dinucleotide binding
HPK19_03795	COG5506	Protein of unknown function (DUF1694)
HPK19_03800	COG4191	Histidine kinase
HPK19_03830	COG1609	Transcriptional regulator
HPK19_03835	COG0561	phosphatase activity
HPK19_03840	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HPK19_03845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPK19_03850	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HPK19_03870	COG0697	spore germination
HPK19_03885	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPK19_03895	COG0588	phosphoglycerate mutase activity
HPK19_03915	COG1509	lysine 2,3-aminomutase activity
HPK19_03920	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPK19_03955	COG0546	phosphoglycolate phosphatase activity
HPK19_03970	COG2226	methyltransferase
HPK19_03975	COG0714	Associated with various cellular activities
HPK19_04000	COG3231	kanamycin kinase activity
HPK19_04030	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPK19_04060	COG2318	DinB family
HPK19_04070	COG3192	ethanolamine utilization protein
HPK19_04080	COG3344	reverse transcriptase
HPK19_04095	COG3011	Protein conserved in bacteria
HPK19_04100	COG1247	-acetyltransferase
HPK19_04150	COG2801	Transposase and inactivated derivatives
HPK19_04170	COG3152	Membrane
HPK19_04175	COG3655	Transcriptional regulator
HPK19_04215	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_04260	COG3344	reverse transcriptase
HPK19_04300	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HPK19_04300	COG5479	isomerase activity
HPK19_04305	COG1525	nuclease
HPK19_04315	COG1404	Belongs to the peptidase S8 family
HPK19_04340	COG1509	lysine 2,3-aminomutase activity
HPK19_04390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPK19_04395	COG0420	3'-5' exonuclease activity
HPK19_04405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK19_04410	COG0765	amino acid transport
HPK19_04425	COG0011	TIGRFAM Protein of
HPK19_04430	COG1309	transcriptional regulator
HPK19_04460	COG1346	cytolysis
HPK19_04465	COG1380	Effector of murein hydrolase LrgA
HPK19_04475	COG0708	Exodeoxyribonuclease III
HPK19_04480	COG1051	belongs to the nudix hydrolase family
HPK19_04490	COG0705	Rhomboid family
HPK19_04505	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HPK19_04515	COG1307	EDD domain protein, DegV family
HPK19_04525	COG2814	Major facilitator Superfamily
HPK19_04530	COG3103	Sh3 type 3 domain protein
HPK19_04535	COG0346	lactoylglutathione lyase activity
HPK19_04550	COG0697	spore germination
HPK19_04555	COG0561	phosphatase activity
HPK19_04570	COG2409	Drug exporters of the RND superfamily
HPK19_04570	COG1033	growth of symbiont in host cell
HPK19_04580	COG4974	Belongs to the 'phage' integrase family
HPK19_04730	COG1131	(ABC) transporter
HPK19_04750	COG0745	RESPONSE REGULATOR receiver
HPK19_04755	COG1404	Belongs to the peptidase S8 family
HPK19_04760	COG3964	amidohydrolase
HPK19_04780	COG2188	Transcriptional regulator
HPK19_04790	COG0346	lactoylglutathione lyase activity
HPK19_04805	COG3706	GGDEF domain
HPK19_04815	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPK19_04820	COG5002	protein histidine kinase activity
HPK19_04825	COG0745	RESPONSE REGULATOR receiver
HPK19_04835	COG3239	Fatty acid desaturase
HPK19_04840	COG4585	Histidine kinase
HPK19_04845	COG2197	response regulator
HPK19_04850	COG2267	carboxylic ester hydrolase activity
HPK19_04865	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HPK19_04880	COG0406	alpha-ribazole phosphatase activity
HPK19_04935	COG2318	DinB family
HPK19_04940	COG1349	DNA-binding transcription factor activity
HPK19_04945	COG1105	Belongs to the carbohydrate kinase PfkB family
HPK19_04950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK19_04950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK19_04950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK19_04955	COG0697	spore germination
HPK19_04960	COG0531	amino acid
HPK19_04970	COG1272	protein, Hemolysin III
HPK19_04980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPK19_05000	COG2733	membrane
HPK19_05005	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPK19_05015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HPK19_05025	COG2706	6-phosphogluconolactonase activity
HPK19_05045	COG1183	phosphatidylcholine synthase activity
HPK19_05085	COG0778	Nitroreductase
HPK19_05090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPK19_05090	COG3153	acetyltransferase
HPK19_05100	COG2801	Transposase and inactivated derivatives
HPK19_05110	COG1846	Transcriptional regulator
HPK19_05115	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_05125	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPK19_05130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPK19_05140	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPK19_05145	COG2270	Major facilitator Superfamily
HPK19_05150	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_05155	COG0681	Belongs to the peptidase S26 family
HPK19_05180	COG1937	Protein conserved in bacteria
HPK19_05190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK19_05210	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPK19_05210	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPK19_05215	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPK19_05215	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPK19_05220	COG1703	isobutyryl-CoA mutase activity
HPK19_05225	COG0346	lactoylglutathione lyase activity
HPK19_05230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPK19_05235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_05245	COG0583	DNA-binding transcription factor activity
HPK19_05255	COG2197	response regulator
HPK19_05265	COG2072	flavoprotein involved in K transport
HPK19_05270	COG2814	Major facilitator Superfamily
HPK19_05280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPK19_05285	COG2146	nitrite reductase [NAD(P)H] activity
HPK19_05290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPK19_05290	COG1587	Uroporphyrinogen-III synthase
HPK19_05300	COG2116	formate transmembrane transporter activity
HPK19_05305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPK19_05310	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HPK19_05335	COG0025	NhaP-type Na H and K H
HPK19_05360	COG1349	DNA-binding transcription factor activity
HPK19_05365	COG0673	inositol 2-dehydrogenase activity
HPK19_05390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPK19_05400	COG2112	serine threonine protein kinase
HPK19_05415	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HPK19_05420	COG2068	MobA-Related Protein
HPK19_05425	COG3852	Histidine kinase
HPK19_05430	COG1073	alpha beta
HPK19_05435	COG4499	WXG100 protein secretion system (Wss), protein YukC
HPK19_05435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPK19_05450	COG1393	Belongs to the ArsC family
HPK19_05470	COG2304	oxidoreductase activity
HPK19_05480	COG1404	Belongs to the peptidase S8 family
HPK19_05485	COG2207	Transcriptional regulator
HPK19_05490	COG0561	phosphatase activity
HPK19_05495	COG2814	Major facilitator Superfamily
HPK19_05500	COG1278	Cold shock
HPK19_05510	COG0745	RESPONSE REGULATOR receiver
HPK19_05525	COG2205	protein histidine kinase activity
HPK19_05535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK19_05540	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HPK19_05545	COG1687	branched-chain amino acid
HPK19_05555	COG0697	spore germination
HPK19_05560	COG0814	amino acid
HPK19_05570	COG3973	AAA domain
HPK19_05575	COG1131	(ABC) transporter
HPK19_05585	COG1902	pentaerythritol trinitrate reductase activity
HPK19_05600	COG2116	formate transmembrane transporter activity
HPK19_05610	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPK19_05610	COG2199	diguanylate cyclase activity
HPK19_05635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPK19_05640	COG4641	Protein conserved in bacteria
HPK19_05650	COG0463	Glycosyl transferase, family 2
HPK19_05655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HPK19_05660	COG1086	Polysaccharide biosynthesis protein
HPK19_05665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPK19_05670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPK19_05675	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPK19_05690	COG2089	acid synthase
HPK19_05700	COG1846	Transcriptional regulator
HPK19_05705	COG2259	Doxx family
HPK19_05710	COG2259	Doxx family
HPK19_05715	COG0114	fumarate hydratase activity
HPK19_05720	COG1940	carbohydrate kinase activity
HPK19_05725	COG0346	lactoylglutathione lyase activity
HPK19_05730	COG0738	Major facilitator superfamily
HPK19_05735	COG1472	Belongs to the glycosyl hydrolase 3 family
HPK19_05750	COG0640	Transcriptional regulator
HPK19_05755	COG0798	PFAM Bile acid sodium symporter
HPK19_05770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK19_05775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK19_05785	COG1846	Transcriptional regulator
HPK19_05790	COG0778	Nitroreductase
HPK19_05815	COG2267	carboxylic ester hydrolase activity
HPK19_05855	COG2959	enzyme of heme biosynthesis
HPK19_05905	COG0745	RESPONSE REGULATOR receiver
HPK19_05910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPK19_05915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK19_05935	COG0166	Belongs to the GPI family
HPK19_05945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPK19_05970	COG3196	Protein conserved in bacteria
HPK19_05985	COG1268	BioY protein
HPK19_05990	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_05995	COG0183	Belongs to the thiolase family
HPK19_06010	COG1280	lysine exporter protein (LysE YggA)
HPK19_06080	COG4978	Transcriptional regulator
HPK19_06080	COG0789	Transcriptional regulator
HPK19_06085	COG2814	Major facilitator Superfamily
HPK19_06105	COG0435	Glutathione S-transferase
HPK19_06110	COG0456	acetyltransferase
HPK19_06150	COG1279	arginine transmembrane transporter activity
HPK19_06165	COG2318	DinB family
HPK19_06170	COG1227	inorganic diphosphatase activity
HPK19_06180	COG4221	oxidoreductase activity
HPK19_06205	COG0469	pyruvate kinase activity
HPK19_06215	COG1404	Belongs to the peptidase S8 family
HPK19_06225	COG4873	Protein conserved in bacteria
HPK19_06230	COG1830	Aldolase
HPK19_06250	COG0393	Putative heavy-metal-binding
HPK19_06265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPK19_06275	COG0586	Pfam SNARE associated Golgi protein
HPK19_06280	COG5002	protein histidine kinase activity
HPK19_06285	COG0745	RESPONSE REGULATOR receiver
HPK19_06290	COG0671	phosphoesterase, PA-phosphatase related
HPK19_06295	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPK19_06300	COG2860	membrane
HPK19_06310	COG0697	spore germination
HPK19_06320	COG1649	PFAM Uncharacterised BCR, COG1649
HPK19_06325	COG0514	ATP-dependent DNA helicase (RecQ)
HPK19_06330	COG1671	Belongs to the UPF0178 family
HPK19_06335	COG1187	pseudouridine synthase activity
HPK19_06340	COG0666	response to abiotic stimulus
HPK19_06345	COG1984	allophanate hydrolase subunit 2
HPK19_06350	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPK19_06355	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPK19_06360	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HPK19_06385	COG1609	Transcriptional regulator
HPK19_06410	COG1316	TRANSCRIPTIONal
HPK19_06415	COG3459	Glycosyltransferase 36 associated
HPK19_06420	COG3459	Glycosyltransferase 36 associated
HPK19_06430	COG0673	inositol 2-dehydrogenase activity
HPK19_06435	COG1082	Xylose isomerase domain protein TIM barrel
HPK19_06515	COG2318	DinB family
HPK19_06520	COG3483	tryptophan 2,3-dioxygenase activity
HPK19_06540	COG1164	Oligoendopeptidase f
HPK19_06545	COG0531	amino acid
HPK19_06555	COG1132	(ABC) transporter
HPK19_06560	COG1132	(ABC) transporter
HPK19_06570	COG3584	3D domain protein
HPK19_06570	COG1388	LysM domain
HPK19_06585	COG0083	homoserine kinase activity
HPK19_06590	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPK19_06595	COG0460	homoserine dehydrogenase
HPK19_06605	COG1410	methionine synthase
HPK19_06605	COG0646	methionine synthase
HPK19_06610	COG0646	methionine synthase
HPK19_06610	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPK19_06615	COG1657	PFAM Prenyltransferase squalene oxidase
HPK19_06640	COG2814	Major facilitator Superfamily
HPK19_06650	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPK19_06660	COG0010	Belongs to the arginase family
HPK19_06665	COG1228	amidohydrolase
HPK19_06675	COG2986	histidine ammonia-lyase
HPK19_06700	COG5609	conserved protein (DUF2294)
HPK19_06705	COG2968	Membrane
HPK19_06715	COG0666	response to abiotic stimulus
HPK19_06720	COG4166	transmembrane transport
HPK19_06730	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPK19_06735	COG0745	RESPONSE REGULATOR receiver
HPK19_06750	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_06755	COG1994	Peptidase M50
HPK19_06770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPK19_06780	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HPK19_06785	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPK19_06790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPK19_06795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_06805	COG0183	Belongs to the thiolase family
HPK19_06810	COG1960	acyl-CoA dehydrogenase activity
HPK19_06815	COG0604	alcohol dehydrogenase
HPK19_06825	COG1307	EDD domain protein, DegV family
HPK19_06830	COG1378	Sugar-specific transcriptional regulator TrmB
HPK19_06850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPK19_06860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPK19_06870	COG0440	acetolactate synthase activity
HPK19_06875	COG0028	Belongs to the TPP enzyme family
HPK19_06880	COG0129	dihydroxy-acid dehydratase activity
HPK19_06885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPK19_06895	COG1174	glycine betaine transport
HPK19_06915	COG0590	tRNA wobble adenosine to inosine editing
HPK19_06920	COG3339	Conserved Protein
HPK19_06925	COG0488	(ABC) transporter
HPK19_06930	COG5658	integral membrane protein
HPK19_06935	COG0640	Transcriptional regulator
HPK19_06940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPK19_06960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPK19_06965	COG2962	Rard protein
HPK19_06970	COG2814	Major facilitator Superfamily
HPK19_06975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPK19_06985	COG0672	)-iron permease
HPK19_06990	COG2837	iron assimilation
HPK19_06995	COG2822	iron ion transport
HPK19_07035	COG1132	(ABC) transporter
HPK19_07045	COG0604	alcohol dehydrogenase
HPK19_07065	COG0456	acetyltransferase
HPK19_07065	COG1214	PFAM Peptidase M22, glycoprotease
HPK19_07070	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_07075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPK19_07080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPK19_07085	COG2197	response regulator
HPK19_07090	COG4585	Histidine kinase
HPK19_07095	COG4758	membrane
HPK19_07105	COG3104	oligopeptide transport
HPK19_07110	COG0756	dUTP diphosphatase activity
HPK19_07115	COG0456	acetyltransferase
HPK19_07145	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_07150	COG1960	acyl-CoA dehydrogenase activity
HPK19_07175	COG1309	transcriptional regulator
HPK19_07180	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_07190	COG1960	acyl-CoA dehydrogenase activity
HPK19_07200	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_07205	COG0477	Major facilitator Superfamily
HPK19_07210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPK19_07215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK19_07220	COG2124	cytochrome p450
HPK19_07230	COG0598	Magnesium transport protein CorA
HPK19_07265	COG0423	glycine-tRNA ligase activity
HPK19_07280	COG0411	ABC transporter
HPK19_07300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPK19_07305	COG0187	DNA topoisomerase II activity
HPK19_07310	COG1832	CoA-binding protein
HPK19_07315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPK19_07320	COG5002	protein histidine kinase activity
HPK19_07325	COG0745	RESPONSE REGULATOR receiver
HPK19_07330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPK19_07335	COG0824	Thioesterase
HPK19_07370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPK19_07375	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPK19_07435	COG5632	N-Acetylmuramoyl-L-alanine amidase
HPK19_07460	COG3953	SLT domain
HPK19_07460	COG5280	Phage tail tape measure protein TP901
HPK19_07525	COG1802	Transcriptional regulator
HPK19_07525	COG4626	Terminase
HPK19_07555	COG0732	type I restriction modification DNA specificity domain
HPK19_07570	COG3655	Transcriptional regulator
HPK19_07610	COG3645	SOS response
HPK19_07610	COG3646	Phage regulatory protein
HPK19_07630	COG1396	sequence-specific DNA binding
HPK19_07640	COG0582	viral genome integration into host DNA
HPK19_07665	COG2719	SpoVR family
HPK19_07675	COG1329	Transcriptional regulator
HPK19_07680	COG1278	Cold shock
HPK19_07720	COG4846	Membrane protein involved in cytochrome C biogenesis
HPK19_07725	COG0785	Cytochrome C biogenesis protein
HPK19_07730	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HPK19_07745	COG1132	(ABC) transporter
HPK19_07750	COG1132	(ABC) transporter
HPK19_07760	COG3763	UPF0154 protein
HPK19_07770	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPK19_07775	COG4224	UPF0291 protein
HPK19_07780	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPK19_07785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPK19_07810	COG1376	ErfK ybiS ycfS ynhG family protein
HPK19_07820	COG2205	protein histidine kinase activity
HPK19_07830	COG1408	metallophosphoesterase
HPK19_07860	COG0659	secondary active sulfate transmembrane transporter activity
HPK19_07875	COG1714	RDD family
HPK19_07880	COG2861	carbohydrate metabolic process
HPK19_07885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPK19_07910	COG5646	InterPro IPR014922
HPK19_07935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPK19_07950	COG5002	protein histidine kinase activity
HPK19_07960	COG1136	(ABC) transporter
HPK19_07965	COG0577	efflux transmembrane transporter activity
HPK19_07970	COG1785	Belongs to the alkaline phosphatase family
HPK19_08015	COG1595	DNA-templated transcription, initiation
HPK19_08025	COG0463	Glycosyl transferase, family 2
HPK19_08060	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPK19_08065	COG1247	-acetyltransferase
HPK19_08105	COG3345	alpha-galactosidase
HPK19_08110	COG0395	ABC-type sugar transport system, permease component
HPK19_08115	COG1175	transmembrane transport
HPK19_08125	COG1609	Transcriptional regulator
HPK19_08135	COG0813	purine-nucleoside phosphorylase activity
HPK19_08150	COG0174	glutamine synthetase
HPK19_08155	COG0174	glutamine synthetase
HPK19_08160	COG0789	Transcriptional regulator
HPK19_08165	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HPK19_08170	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HPK19_08175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPK19_08180	COG0436	Aminotransferase
HPK19_08185	COG1850	ribulose-bisphosphate carboxylase activity
HPK19_08195	COG0235	Class ii aldolase
HPK19_08205	COG2323	membrane
HPK19_08210	COG0531	amino acid
HPK19_08235	COG1309	transcriptional regulator
HPK19_08240	COG2814	Major facilitator Superfamily
HPK19_08245	COG1231	oxidoreductase activity
HPK19_08250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPK19_08255	COG2720	vancomycin resistance protein
HPK19_08270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HPK19_08285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPK19_08290	COG2070	2-Nitropropane dioxygenase
HPK19_08325	COG1278	Cold shock
HPK19_08345	COG1051	belongs to the nudix hydrolase family
HPK19_08400	COG2723	6-phospho-beta-galactosidase activity
HPK19_08410	COG0501	Belongs to the peptidase M48B family
HPK19_08415	COG1376	ErfK ybiS ycfS ynhG family protein
HPK19_08445	COG1819	glycosyl
HPK19_08480	COG1846	Transcriptional regulator
HPK19_08490	COG3739	integral membrane protein
HPK19_08495	COG3655	Transcriptional regulator
HPK19_08530	COG0477	Major facilitator Superfamily
HPK19_08540	COG2824	Alkylphosphonate utilization operon protein PhnA
HPK19_08545	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HPK19_08550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPK19_08565	COG0598	Magnesium transport protein CorA
HPK19_08570	COG0464	growth
HPK19_08580	COG2808	Putative FMN-binding domain
HPK19_08595	COG0167	dihydroorotate dehydrogenase activity
HPK19_08610	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPK19_08620	COG2814	Major facilitator Superfamily
HPK19_08625	COG0531	amino acid
HPK19_08645	COG2814	Major facilitator Superfamily
HPK19_08650	COG1902	pentaerythritol trinitrate reductase activity
HPK19_08660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPK19_08665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPK19_08675	COG2801	Transposase and inactivated derivatives
HPK19_08710	COG0656	L-ascorbic acid biosynthetic process
HPK19_08715	COG0584	glycerophosphoryl diester phosphodiesterase
HPK19_08725	COG0395	ABC-type sugar transport system, permease component
HPK19_08730	COG4209	transmembrane transport
HPK19_08735	COG1653	transport
HPK19_08740	COG1609	Transcriptional regulator
HPK19_08750	COG0383	alpha-mannosidase activity
HPK19_08760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK19_08760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK19_08770	COG3718	enzyme involved in inositol metabolism
HPK19_08775	COG1082	Xylose isomerase domain protein TIM barrel
HPK19_08780	COG3962	Belongs to the TPP enzyme family
HPK19_08795	COG0673	inositol 2-dehydrogenase activity
HPK19_08800	COG1609	Transcriptional regulator
HPK19_08815	COG0346	lactoylglutathione lyase activity
HPK19_08830	COG0110	maltose O-acetyltransferase activity
HPK19_08835	COG2226	methyltransferase
HPK19_08850	COG0626	cystathionine gamma-synthase activity
HPK19_08855	COG0626	cystathionine gamma-synthase activity
HPK19_08860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPK19_08860	COG1199	ATP-dependent helicase activity
HPK19_08870	COG1132	(ABC) transporter
HPK19_08875	COG1132	(ABC) transporter
HPK19_08880	COG0366	Alpha amylase catalytic
HPK19_08885	COG1376	ErfK ybiS ycfS ynhG family protein
HPK19_08890	COG1363	Peptidase, m42
HPK19_08900	COG3961	Belongs to the TPP enzyme family
HPK19_08925	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_08930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPK19_08935	COG0488	(ABC) transporter
HPK19_08940	COG1607	acyl-coa hydrolase
HPK19_08980	COG0456	acetyltransferase
HPK19_09010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPK19_09045	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HPK19_09080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPK19_09080	COG0140	phosphoribosyl-ATP diphosphatase activity
HPK19_09085	COG0107	imidazoleglycerol-phosphate synthase activity
HPK19_09090	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPK19_09095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPK19_09100	COG0131	Imidazoleglycerol-phosphate dehydratase
HPK19_09105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPK19_09110	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPK19_09115	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HPK19_09160	COG1051	belongs to the nudix hydrolase family
HPK19_09165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPK19_09170	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPK19_09175	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPK19_09180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPK19_09185	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HPK19_09190	COG1733	regulation of RNA biosynthetic process
HPK19_09195	COG0655	NAD(P)H dehydrogenase (quinone) activity
HPK19_09200	COG1979	alcohol dehydrogenase
HPK19_09205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK19_09215	COG0346	lactoylglutathione lyase activity
HPK19_09220	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPK19_09235	COG4550	Control of competence regulator ComK, YlbF/YmcA
HPK19_09240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPK19_09245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPK19_09255	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPK19_09260	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPK19_09260	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPK19_09270	COG2359	stage V sporulation protein S
HPK19_09275	COG1692	metallophosphoesterase
HPK19_09280	COG1418	mRNA catabolic process
HPK19_09290	COG1058	Belongs to the CinA family
HPK19_09290	COG1546	Belongs to the CinA family
HPK19_09295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPK19_09300	COG1426	Protein conserved in bacteria
HPK19_09310	COG0300	oxidoreductase activity
HPK19_09315	COG0612	Peptidase, M16
HPK19_09320	COG0612	Peptidase, M16
HPK19_09340	COG1744	ABC transporter substrate-binding protein PnrA-like
HPK19_09345	COG2188	Transcriptional regulator
HPK19_09360	COG0740	serine-type endopeptidase activity
HPK19_09365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPK19_09370	COG0574	Belongs to the PEP-utilizing enzyme family
HPK19_09370	COG3848	Pyruvate phosphate dikinase
HPK19_09375	COG2132	Multicopper oxidase
HPK19_09385	COG0527	aspartate kinase activity
HPK19_09390	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPK19_09395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPK19_09415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPK19_09420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPK19_09425	COG0612	Peptidase, M16
HPK19_09430	COG0726	polysaccharide deacetylase
HPK19_09435	COG1185	polyribonucleotide nucleotidyltransferase activity
HPK19_09445	COG0196	riboflavin kinase activity
HPK19_09455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPK19_09460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPK19_09465	COG1358	cellular component organization or biogenesis
HPK19_09470	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HPK19_09475	COG0195	Participates in both transcription termination and antitermination
HPK19_09480	COG0779	Required for maturation of 30S ribosomal subunits
HPK19_09495	COG0750	zinc metalloprotease
HPK19_09500	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPK19_09505	COG4589	Belongs to the CDS family
HPK19_09515	COG0233	cytoplasmic translational termination
HPK19_09525	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPK19_09530	COG0052	Belongs to the universal ribosomal protein uS2 family
HPK19_09535	COG1191	sigma factor activity
HPK19_09540	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HPK19_09545	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPK19_09550	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPK19_09555	COG4974	Belongs to the 'phage' integrase family
HPK19_09565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPK19_09570	COG0758	DNA mediated transformation
HPK19_09570	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPK19_09575	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPK19_09585	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPK19_09610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPK19_09615	COG1837	Belongs to the UPF0109 family
HPK19_09625	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPK19_09630	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HPK19_09635	COG0552	protein localization to endoplasmic reticulum
HPK19_09640	COG1196	nuclear chromosome segregation
HPK19_09645	COG0571	ribonuclease III activity
HPK19_09650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPK19_09655	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_09660	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPK19_09670	COG1349	DNA-binding transcription factor activity
HPK19_09675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPK19_09680	COG1760	l-serine dehydratase
HPK19_09685	COG1760	l-serine dehydratase
HPK19_09690	COG1461	Dihydroxyacetone kinase
HPK19_09695	COG1302	Protein conserved in bacteria
HPK19_09700	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPK19_09710	COG1564	THIamine pyrophosphokinase
HPK19_09715	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPK19_09720	COG1162	GTPase activity
HPK19_09725	COG0515	serine threonine protein kinase
HPK19_09725	COG2815	serine threonine protein kinase
HPK19_09730	COG0631	protein serine/threonine phosphatase activity
HPK19_09740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPK19_09740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPK19_09745	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPK19_09755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPK19_09760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPK19_09765	COG1758	RNA polymerase activity
HPK19_09775	COG1561	YicC-like family, N-terminal region
HPK19_09780	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPK19_09800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPK19_09805	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HPK19_09810	COG1132	(ABC) transporter
HPK19_09815	COG1132	(ABC) transporter
HPK19_09830	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HPK19_09855	COG3344	reverse transcriptase
HPK19_09870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPK19_09885	COG0543	2 iron, 2 sulfur cluster binding
HPK19_09890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPK19_09900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPK19_09905	COG0540	Belongs to the ATCase OTCase family
HPK19_09920	COG0564	pseudouridine synthase activity
HPK19_09930	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPK19_09940	COG2340	Cysteine-rich secretory protein family
HPK19_09950	COG3599	regulation of cell shape
HPK19_09955	COG2302	S4 RNA-binding domain
HPK19_09960	COG0762	integral membrane protein
HPK19_09965	COG1799	cell septum assembly
HPK19_09970	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPK19_09980	COG1873	PFAM PRC-barrel domain
HPK19_09985	COG1191	sigma factor activity
HPK19_09990	COG1191	sigma factor activity
HPK19_10000	COG0438	transferase activity, transferring glycosyl groups
HPK19_10000	COG1216	Glycosyl transferase, family 2
HPK19_10005	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPK19_10010	COG0849	cell division
HPK19_10015	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPK19_10030	COG0772	Belongs to the SEDS family
HPK19_10040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPK19_10045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPK19_10050	COG0768	penicillin binding
HPK19_10065	COG0275	rRNA processing
HPK19_10070	COG2001	Belongs to the MraZ family
HPK19_10085	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPK19_10090	COG0454	-acetyltransferase
HPK19_10100	COG1024	Enoyl-CoA hydratase
HPK19_10105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPK19_10110	COG1399	metal-binding, possibly nucleic acid-binding protein
HPK19_10115	COG1323	Belongs to the UPF0348 family
HPK19_10120	COG3480	Lon protease (S16) C-terminal proteolytic domain
HPK19_10125	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPK19_10130	COG3314	Sporulation integral membrane protein YlbJ
HPK19_10135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPK19_10140	COG0742	ribosomal rna small subunit methyltransferase
HPK19_10150	COG4471	UPF0298 protein
HPK19_10155	COG3679	Belongs to the UPF0342 family
HPK19_10160	COG0406	alpha-ribazole phosphatase activity
HPK19_10175	COG2340	Cysteine-rich secretory protein family
HPK19_10190	COG3336	cytochrome c oxidase
HPK19_10195	COG0583	DNA-binding transcription factor activity
HPK19_10200	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HPK19_10205	COG1845	cytochrome c oxidase, subunit III
HPK19_10210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPK19_10220	COG0109	protoheme IX farnesyltransferase activity
HPK19_10225	COG1612	heme a metabolic process
HPK19_10230	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HPK19_10235	COG0772	Belongs to the SEDS family
HPK19_10240	COG4838	Belongs to the UPF0358 family
HPK19_10250	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPK19_10255	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPK19_10265	COG4896	Protein conserved in bacteria
HPK19_10290	COG0483	inositol monophosphate 1-phosphatase activity
HPK19_10305	COG4476	Belongs to the UPF0223 family
HPK19_10310	COG1982	Orn Lys Arg decarboxylase major
HPK19_10350	COG0022	dehydrogenase e1 component
HPK19_10355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPK19_10370	COG0242	peptide deformylase activity
HPK19_10375	COG0561	phosphatase activity
HPK19_10390	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPK19_10405	COG1294	oxidase, subunit
HPK19_10410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPK19_10415	COG0450	alkyl hydroperoxide reductase
HPK19_10420	COG1473	amidohydrolase
HPK19_10430	COG0583	DNA-binding transcription factor activity
HPK19_10435	COG0517	IMP dehydrogenase activity
HPK19_10445	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HPK19_10450	COG4703	Protein of unknown function (DUF1797)
HPK19_10465	COG2200	EAL domain
HPK19_10470	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_10475	COG1408	metallophosphoesterase
HPK19_10500	COG2205	protein histidine kinase activity
HPK19_10505	COG0598	Magnesium transport protein CorA
HPK19_10510	COG0436	Aminotransferase
HPK19_10520	COG2084	Dehydrogenase
HPK19_10525	COG0778	Nitroreductase
HPK19_10530	COG0640	Transcriptional regulator
HPK19_10545	COG1263	PTS System
HPK19_10545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK19_10545	COG2190	(PTS) system
HPK19_10550	COG3711	transcriptional antiterminator
HPK19_10555	COG0561	phosphatase activity
HPK19_10560	COG2188	Transcriptional regulator
HPK19_10570	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPK19_10575	COG0658	competence protein
HPK19_10575	COG2333	competence protein COMEC
HPK19_10595	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPK19_10600	COG1801	Protein of unknown function DUF72
HPK19_10605	COG5002	protein histidine kinase activity
HPK19_10610	COG3321	synthase
HPK19_10610	COG0604	alcohol dehydrogenase
HPK19_10610	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_10615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPK19_10620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPK19_10625	COG1780	Probably involved in ribonucleotide reductase function
HPK19_10640	COG4873	Protein conserved in bacteria
HPK19_10645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPK19_10655	COG1846	Transcriptional regulator
HPK19_10665	COG0235	Class ii aldolase
HPK19_10670	COG1032	radical SAM domain protein
HPK19_10685	COG5577	PFAM Coat F domain
HPK19_10695	COG2323	membrane
HPK19_10730	COG2030	dehydratase
HPK19_10740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK19_10740	COG1263	PTS System
HPK19_10750	COG2340	Cysteine-rich secretory protein family
HPK19_10755	COG3142	Participates in the control of copper homeostasis
HPK19_10760	COG0564	pseudouridine synthase activity
HPK19_10765	COG1454	alcohol dehydrogenase
HPK19_10765	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_10770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPK19_10780	COG1846	Transcriptional regulator
HPK19_10785	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPK19_10790	COG1177	transmembrane transport
HPK19_10795	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPK19_10800	COG3842	ATPase activity
HPK19_10805	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_10810	COG1392	Phosphate transport regulator
HPK19_10815	COG0306	phosphate transporter
HPK19_10820	COG1686	Belongs to the peptidase S11 family
HPK19_10830	COG2223	nitrite transmembrane transporter activity
HPK19_10835	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HPK19_10855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPK19_10870	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPK19_10900	COG2843	Capsule synthesis protein
HPK19_10905	COG0714	Associated with various cellular activities
HPK19_10920	COG4948	Mandelate Racemase Muconate Lactonizing
HPK19_10930	COG1473	amidohydrolase
HPK19_10950	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPK19_10955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPK19_10960	COG0438	transferase activity, transferring glycosyl groups
HPK19_10965	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPK19_10975	COG1404	Belongs to the peptidase S8 family
HPK19_10985	COG0697	spore germination
HPK19_10990	COG0531	amino acid
HPK19_11000	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPK19_11005	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPK19_11015	COG0697	spore germination
HPK19_11020	COG1404	Belongs to the peptidase S8 family
HPK19_11030	COG1113	amino acid transport
HPK19_11035	COG3844	kynureninase activity
HPK19_11040	COG1309	transcriptional regulator
HPK19_11045	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_11060	COG1309	transcriptional regulator
HPK19_11075	COG0833	amino acid
HPK19_11080	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPK19_11085	COG0697	spore germination
HPK19_11090	COG0583	DNA-binding transcription factor activity
HPK19_11095	COG0628	permease
HPK19_11110	COG2080	2 iron, 2 sulfur cluster binding
HPK19_11120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HPK19_11125	COG0697	spore germination
HPK19_11145	COG1404	Belongs to the peptidase S8 family
HPK19_11150	COG0583	DNA-binding transcription factor activity
HPK19_11155	COG1404	Belongs to the peptidase S8 family
HPK19_11160	COG0531	amino acid
HPK19_11175	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPK19_11180	COG0789	Transcriptional regulator
HPK19_11185	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_11190	COG2205	protein histidine kinase activity
HPK19_11195	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HPK19_11200	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HPK19_11220	COG0517	IMP dehydrogenase activity
HPK19_11225	COG1511	domain protein
HPK19_11230	COG1309	transcriptional regulator
HPK19_11235	COG0583	DNA-binding transcription factor activity
HPK19_11250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPK19_11255	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_11270	COG0167	dihydroorotate dehydrogenase activity
HPK19_11275	COG0493	'glutamate synthase
HPK19_11285	COG2738	Putative neutral zinc metallopeptidase
HPK19_11290	COG0789	Transcriptional regulator
HPK19_11295	COG0697	spore germination
HPK19_11315	COG4948	Mandelate Racemase Muconate Lactonizing
HPK19_11325	COG0737	Belongs to the 5'-nucleotidase family
HPK19_11330	COG0583	DNA-binding transcription factor activity
HPK19_11345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPK19_11355	COG4638	Rieske (2fe-2S)
HPK19_11365	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_11370	COG0028	Belongs to the TPP enzyme family
HPK19_11375	COG1960	acyl-CoA dehydrogenase activity
HPK19_11380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPK19_11390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPK19_11395	COG0833	amino acid
HPK19_11400	COG1404	Belongs to the peptidase S8 family
HPK19_11405	COG1404	Belongs to the peptidase S8 family
HPK19_11415	COG1404	Belongs to the peptidase S8 family
HPK19_11420	COG0697	spore germination
HPK19_11425	COG0531	amino acid
HPK19_11445	COG1404	Belongs to the peptidase S8 family
HPK19_11450	COG0667	Aldo Keto reductase
HPK19_11465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPK19_11470	COG0789	Transcriptional regulator
HPK19_11475	COG1064	alcohol dehydrogenase
HPK19_11490	COG1280	lysine exporter protein (LysE YggA)
HPK19_11495	COG0789	Transcriptional regulator
HPK19_11495	COG4978	Transcriptional regulator
HPK19_11525	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPK19_11530	COG0398	Pfam SNARE associated Golgi protein
HPK19_11535	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPK19_11545	COG0463	Glycosyl transferase, family 2
HPK19_11555	COG1846	Transcriptional regulator
HPK19_11580	COG1404	Belongs to the peptidase S8 family
HPK19_11585	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_11590	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_11610	COG1960	acyl-CoA dehydrogenase activity
HPK19_11615	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPK19_11620	COG0183	Belongs to the thiolase family
HPK19_11625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPK19_11630	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPK19_11645	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_11655	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_11660	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_11665	COG1024	Enoyl-CoA hydratase
HPK19_11675	COG0183	Belongs to the thiolase family
HPK19_11680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPK19_11690	COG0583	DNA-binding transcription factor activity
HPK19_11695	COG0656	L-ascorbic acid biosynthetic process
HPK19_11720	COG1404	Belongs to the peptidase S8 family
HPK19_11725	COG1404	Belongs to the peptidase S8 family
HPK19_11730	COG1404	Belongs to the peptidase S8 family
HPK19_11735	COG1404	Belongs to the peptidase S8 family
HPK19_11740	COG1404	Belongs to the peptidase S8 family
HPK19_11745	COG1404	Belongs to the peptidase S8 family
HPK19_11760	COG1404	Belongs to the peptidase S8 family
HPK19_11765	COG1404	Belongs to the peptidase S8 family
HPK19_11775	COG1404	Belongs to the peptidase S8 family
HPK19_11780	COG1404	Belongs to the peptidase S8 family
HPK19_11795	COG1404	Belongs to the peptidase S8 family
HPK19_11800	COG0583	DNA-binding transcription factor activity
HPK19_11805	COG1404	Belongs to the peptidase S8 family
HPK19_11815	COG1063	alcohol dehydrogenase
HPK19_11835	COG1231	oxidoreductase activity
HPK19_11840	COG0386	Belongs to the glutathione peroxidase family
HPK19_11900	COG0582	viral genome integration into host DNA
HPK19_11925	COG0569	domain protein
HPK19_11930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPK19_11940	COG2382	esterase
HPK19_11950	COG2153	protein acetylation
HPK19_11955	COG0210	DNA helicase
HPK19_11995	COG0772	Belongs to the SEDS family
HPK19_12005	COG0564	pseudouridine synthase activity
HPK19_12015	COG2357	RelA SpoT domain protein
HPK19_12025	COG4116	CYTH
HPK19_12035	COG1164	Oligoendopeptidase f
HPK19_12045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPK19_12055	COG0861	Integral membrane protein TerC family
HPK19_12070	COG4608	Belongs to the ABC transporter superfamily
HPK19_12075	COG0444	Belongs to the ABC transporter superfamily
HPK19_12080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPK19_12085	COG0601	transmembrane transport
HPK19_12095	COG0180	Tryptophanyl-tRNA synthetase
HPK19_12105	COG5504	Zn-dependent protease
HPK19_12110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPK19_12115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPK19_12125	COG2267	carboxylic ester hydrolase activity
HPK19_12140	COG0561	phosphatase activity
HPK19_12160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPK19_12170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPK19_12175	COG2996	Protein conserved in bacteria
HPK19_12180	COG1666	GTP binding
HPK19_12185	COG1609	Transcriptional regulator
HPK19_12190	COG0366	Alpha amylase catalytic
HPK19_12190	COG1874	Beta-galactosidase
HPK19_12200	COG0004	ammonium transporteR
HPK19_12205	COG0347	Belongs to the P(II) protein family
HPK19_12210	COG0367	asparagine synthase
HPK19_12260	COG1074	ATP-dependent DNA helicase activity
HPK19_12265	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HPK19_12275	COG0398	Pfam SNARE associated Golgi protein
HPK19_12280	COG4903	ComK protein
HPK19_12285	COG2224	Isocitrate lyase
HPK19_12290	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPK19_12295	COG0501	Belongs to the peptidase M48B family
HPK19_12300	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_12305	COG0095	Lipoate-protein ligase
HPK19_12310	COG1234	tRNA 3'-trailer cleavage
HPK19_12330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPK19_12335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPK19_12340	COG1473	amidohydrolase
HPK19_12350	COG4473	ABC transporter
HPK19_12355	COG1131	(ABC) transporter
HPK19_12360	COG0537	adenosine 5'-monophosphoramidase activity
HPK19_12365	COG1846	Transcriptional regulator
HPK19_12390	COG3481	metal-dependent phosphohydrolase, HD sub domain
HPK19_12405	COG1024	Enoyl-CoA hydratase
HPK19_12410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPK19_12415	COG0561	phosphatase activity
HPK19_12430	COG0189	ligase activity
HPK19_12435	COG0189	ligase activity
HPK19_12445	COG2508	Transcriptional regulator
HPK19_12450	COG3842	ATPase activity
HPK19_12465	COG1126	abc transporter atp-binding protein
HPK19_12470	COG0765	amino acid transport
HPK19_12475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK19_12480	COG4535	Mg2 and Co2 transporter CorC
HPK19_12485	COG1253	flavin adenine dinucleotide binding
HPK19_12490	COG0789	Transcriptional regulator
HPK19_12505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPK19_12510	COG0183	Belongs to the thiolase family
HPK19_12515	COG3829	transcription factor binding
HPK19_12515	COG3290	protein histidine kinase activity
HPK19_12520	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_12525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPK19_12530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPK19_12535	COG2610	gluconate transmembrane transporter activity
HPK19_12545	COG1404	Belongs to the peptidase S8 family
HPK19_12550	COG1408	metallophosphoesterase
HPK19_12555	COG0110	maltose O-acetyltransferase activity
HPK19_12570	COG0165	Argininosuccinate lyase
HPK19_12575	COG0137	argininosuccinate synthase activity
HPK19_12580	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPK19_12585	COG0783	Belongs to the Dps family
HPK19_12590	COG3541	Predicted nucleotidyltransferase
HPK19_12605	COG2223	nitrite transmembrane transporter activity
HPK19_12610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK19_12615	COG0586	Pfam SNARE associated Golgi protein
HPK19_12620	COG2217	Heavy metal translocating P-type atpase
HPK19_12625	COG0640	Transcriptional regulator
HPK19_12655	COG4912	Dna alkylation repair
HPK19_12665	COG0288	reversible hydration of carbon dioxide
HPK19_12670	COG0656	L-ascorbic acid biosynthetic process
HPK19_12675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPK19_12695	COG5002	protein histidine kinase activity
HPK19_12700	COG0745	RESPONSE REGULATOR receiver
HPK19_12720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPK19_12720	COG0723	plastoquinol--plastocyanin reductase activity
HPK19_12745	COG1690	Belongs to the RtcB family
HPK19_12755	COG0456	acetyltransferase
HPK19_12760	COG1335	isochorismatase
HPK19_12765	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPK19_12770	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPK19_12785	COG1231	oxidoreductase activity
HPK19_12795	COG1525	nuclease
HPK19_12800	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPK19_12805	COG0697	spore germination
HPK19_12830	COG2059	Chromate
HPK19_12835	COG2059	Chromate
HPK19_12850	COG1802	Transcriptional regulator
HPK19_12870	COG3069	C4-dicarboxylate transmembrane transporter activity
HPK19_12900	COG2329	Antibiotic biosynthesis monooxygenase
HPK19_12910	COG2814	Major facilitator Superfamily
HPK19_12920	COG3832	glyoxalase III activity
HPK19_12945	COG5002	protein histidine kinase activity
HPK19_12950	COG0745	RESPONSE REGULATOR receiver
HPK19_12970	COG1231	oxidoreductase activity
HPK19_12975	COG0456	acetyltransferase
HPK19_13030	COG0753	catalase activity
HPK19_13045	COG2801	Transposase and inactivated derivatives
HPK19_13050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPK19_13080	COG1349	DNA-binding transcription factor activity
HPK19_13095	COG0716	FMN binding
HPK19_13120	COG1122	ATPase activity
HPK19_13160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPK19_13175	COG0473	3-isopropylmalate dehydrogenase activity
HPK19_13180	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_13185	COG4638	Rieske (2fe-2S)
HPK19_13195	COG1316	TRANSCRIPTIONal
HPK19_13210	COG2801	Transposase and inactivated derivatives
HPK19_13225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK19_13245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPK19_13245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPK19_13250	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPK19_13250	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPK19_13260	COG1733	regulation of RNA biosynthetic process
HPK19_13265	COG1404	Belongs to the peptidase S8 family
HPK19_13270	COG1404	Belongs to the peptidase S8 family
HPK19_13275	COG1404	Belongs to the peptidase S8 family
HPK19_13285	COG0583	DNA-binding transcription factor activity
HPK19_13310	COG0583	DNA-binding transcription factor activity
HPK19_13315	COG1404	Belongs to the peptidase S8 family
HPK19_13335	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPK19_13345	COG0412	Dienelactone hydrolase
HPK19_13350	COG2814	Major facilitator Superfamily
HPK19_13365	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPK19_13370	COG1910	domain protein
HPK19_13415	COG3964	amidohydrolase
HPK19_13435	COG0577	efflux transmembrane transporter activity
HPK19_13440	COG1136	(ABC) transporter
HPK19_13450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPK19_13480	COG1473	amidohydrolase
HPK19_13490	COG1113	amino acid transport
HPK19_13500	COG3655	Transcriptional regulator
HPK19_13505	COG0069	glutamate synthase activity
HPK19_13530	COG2271	Major facilitator Superfamily
HPK19_13540	COG1737	Transcriptional regulator
HPK19_13545	COG2971	BadF BadG BcrA BcrD
HPK19_13550	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPK19_13555	COG2723	6-phospho-beta-galactosidase activity
HPK19_13560	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPK19_13565	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_13570	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_13575	COG3711	transcriptional antiterminator
HPK19_13575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK19_13590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_13595	COG2271	Major facilitator Superfamily
HPK19_13610	COG2719	SpoVR family
HPK19_13620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPK19_13630	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_13635	COG2252	PERMEase
HPK19_13645	COG4667	esterase of the alpha-beta hydrolase superfamily
HPK19_13650	COG2366	antibiotic biosynthetic process
HPK19_13660	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HPK19_13665	COG0791	NLP P60 protein
HPK19_13665	COG1388	LysM domain
HPK19_13670	COG0366	Alpha amylase catalytic
HPK19_13680	COG0789	Transcriptional regulator
HPK19_13685	COG3695	enzyme binding
HPK19_13695	COG4841	protein insertion into membrane
HPK19_13700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPK19_13705	COG3850	Histidine kinase
HPK19_13705	COG5002	protein histidine kinase activity
HPK19_13725	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HPK19_13725	COG0392	lysyltransferase activity
HPK19_13730	COG1846	Transcriptional regulator
HPK19_13735	COG1764	response to oxidative stress
HPK19_13740	COG0390	transport system, permease component
HPK19_13745	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPK19_13750	COG1120	ATPase activity
HPK19_13755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK19_13760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK19_13765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPK19_13775	COG4565	transcriptional regulatory protein
HPK19_13780	COG3290	protein histidine kinase activity
HPK19_13810	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPK19_13820	COG5002	protein histidine kinase activity
HPK19_13825	COG0745	RESPONSE REGULATOR receiver
HPK19_13855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK19_13860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPK19_13865	COG0748	coenzyme F420 binding
HPK19_13880	COG4335	DNA alkylation repair
HPK19_13895	COG0406	alpha-ribazole phosphatase activity
HPK19_13900	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPK19_13905	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HPK19_13925	COG1404	Belongs to the peptidase S8 family
HPK19_13930	COG1404	Belongs to the peptidase S8 family
HPK19_13940	COG1737	Transcriptional regulator
HPK19_13955	COG1404	Belongs to the peptidase S8 family
HPK19_13960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_13965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPK19_13980	COG2264	protein methyltransferase activity
HPK19_13995	COG0307	riboflavin synthase, alpha
HPK19_14005	COG0583	DNA-binding transcription factor activity
HPK19_14020	COG1609	Transcriptional regulator
HPK19_14030	COG0531	amino acid
HPK19_14060	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPK19_14065	COG0352	thiamine-phosphate diphosphorylase activity
HPK19_14075	COG2104	thiamine diphosphate biosynthetic process
HPK19_14080	COG2022	thiamine diphosphate biosynthetic process
HPK19_14085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPK19_14095	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_14100	COG1027	Aspartate ammonia-lyase
HPK19_14105	COG1414	Transcriptional regulator
HPK19_14110	COG0477	Major facilitator Superfamily
HPK19_14115	COG2608	mercury ion transmembrane transporter activity
HPK19_14120	COG2217	Heavy metal translocating P-type atpase
HPK19_14125	COG1937	Protein conserved in bacteria
HPK19_14145	COG1960	acyl-CoA dehydrogenase activity
HPK19_14150	COG0789	Transcriptional regulator
HPK19_14155	COG0028	Belongs to the TPP enzyme family
HPK19_14160	COG1136	(ABC) transporter
HPK19_14165	COG0577	efflux transmembrane transporter activity
HPK19_14210	COG3227	Zinc metalloprotease (Elastase)
HPK19_14225	COG0697	spore germination
HPK19_14240	COG4978	Transcriptional regulator
HPK19_14240	COG0789	Transcriptional regulator
HPK19_14260	COG1288	antiporter activity
HPK19_14265	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPK19_14275	COG1464	Belongs to the NlpA lipoprotein family
HPK19_14280	COG2011	ABC-type metal ion transport system permease component
HPK19_14285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPK19_14295	COG0730	response to heat
HPK19_14300	COG0425	Belongs to the sulfur carrier protein TusA family
HPK19_14305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_14305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK19_14310	COG0425	Belongs to the sulfur carrier protein TusA family
HPK19_14310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK19_14320	COG2210	Belongs to the sulfur carrier protein TusA family
HPK19_14325	COG1937	Protein conserved in bacteria
HPK19_14335	COG3048	D-serine ammonia-lyase activity
HPK19_14340	COG2059	Chromate
HPK19_14350	COG0531	amino acid
HPK19_14370	COG1929	Belongs to the glycerate kinase type-1 family
HPK19_14375	COG1554	hydrolase, family 65, central catalytic
HPK19_14380	COG0673	inositol 2-dehydrogenase activity
HPK19_14385	COG1082	Xylose isomerase domain protein TIM barrel
HPK19_14390	COG1063	alcohol dehydrogenase
HPK19_14395	COG0395	ABC-type sugar transport system, permease component
HPK19_14400	COG1175	transmembrane transport
HPK19_14405	COG1653	transport
HPK19_14410	COG0366	Alpha amylase catalytic
HPK19_14415	COG1609	Transcriptional regulator
HPK19_14420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPK19_14430	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPK19_14440	COG0586	Pfam SNARE associated Golgi protein
HPK19_14445	COG3850	Histidine kinase
HPK19_14445	COG5002	protein histidine kinase activity
HPK19_14450	COG0745	RESPONSE REGULATOR receiver
HPK19_14455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPK19_14485	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HPK19_14490	COG1309	transcriptional regulator
HPK19_14505	COG2801	Transposase and inactivated derivatives
HPK19_14515	COG0456	acetyltransferase
HPK19_14520	COG1846	Transcriptional regulator
HPK19_14525	COG2153	protein acetylation
HPK19_14530	COG2364	Membrane
HPK19_14535	COG2890	protein-(glutamine-N5) methyltransferase activity
HPK19_14550	COG1404	Belongs to the peptidase S8 family
HPK19_14575	COG1404	Belongs to the peptidase S8 family
HPK19_14585	COG1404	Belongs to the peptidase S8 family
HPK19_14590	COG4126	flavin adenine dinucleotide binding
HPK19_14625	COG2323	membrane
HPK19_14635	COG1404	Belongs to the peptidase S8 family
HPK19_14640	COG1404	Belongs to the peptidase S8 family
HPK19_14650	COG1113	amino acid transport
HPK19_14655	COG1114	Component of the transport system for branched-chain amino acids
HPK19_14660	COG5522	Integral membrane protein (intg_mem_TP0381)
HPK19_14665	COG3588	fructose-bisphosphate aldolase
HPK19_14675	COG2814	Major facilitator Superfamily
HPK19_14680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPK19_14685	COG0590	tRNA wobble adenosine to inosine editing
HPK19_14690	COG1953	Uracil, thiamine, allantoin
HPK19_14695	COG0549	Belongs to the carbamate kinase family
HPK19_14705	COG1304	FMN binding
HPK19_14710	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPK19_14720	COG2508	Transcriptional regulator
HPK19_14740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK19_14745	COG0697	spore germination
HPK19_14750	COG1522	sequence-specific DNA binding
HPK19_14755	COG0288	reversible hydration of carbon dioxide
HPK19_14775	COG2329	Antibiotic biosynthesis monooxygenase
HPK19_14800	COG2718	Belongs to the UPF0229 family
HPK19_14805	COG4989	oxidoreductase activity
HPK19_14810	COG2766	serine protein kinase
HPK19_14815	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPK19_14825	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPK19_14930	COG1285	pathogenesis
HPK19_14935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPK19_14950	COG2155	Conserved Protein
HPK19_14955	COG1098	S1 RNA binding domain
HPK19_14960	COG2267	carboxylic ester hydrolase activity
HPK19_14965	COG5002	protein histidine kinase activity
HPK19_14970	COG0745	RESPONSE REGULATOR receiver
HPK19_14990	COG5018	Exonuclease
HPK19_14995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPK19_15005	COG2050	protein possibly involved in aromatic compounds catabolism
HPK19_15015	COG3584	3D domain protein
HPK19_15030	COG1252	NADH dehydrogenase
HPK19_15050	COG1252	NADH dehydrogenase
HPK19_15065	COG4837	Protein of unknown function (DUF1462)
HPK19_15070	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HPK19_15075	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPK19_15080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPK19_15085	COG0647	UMP catabolic process
HPK19_15090	COG2445	Protein of unknown function DUF86
HPK19_15100	COG4470	Protein conserved in bacteria
HPK19_15110	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPK19_15115	COG0739	heme binding
HPK19_15130	COG3377	Domain of unknown function (DUF1805)
HPK19_15135	COG0737	Belongs to the 5'-nucleotidase family
HPK19_15140	COG0730	response to heat
HPK19_15150	COG1404	Belongs to the peptidase S8 family
HPK19_15155	COG0719	Fe-S assembly protein
HPK19_15160	COG0822	iron-sulfur transferase activity
HPK19_15165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPK19_15170	COG0719	Fe-S assembly protein
HPK19_15175	COG0396	ATPase activity
HPK19_15190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPK19_15205	COG1696	Membrane protein involved in D-alanine export
HPK19_15210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPK19_15215	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HPK19_15220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPK19_15225	COG1464	Belongs to the NlpA lipoprotein family
HPK19_15230	COG2011	ABC-type metal ion transport system permease component
HPK19_15235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPK19_15245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPK19_15250	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HPK19_15255	COG0509	glycine decarboxylation via glycine cleavage system
HPK19_15260	COG1393	Belongs to the ArsC family
HPK19_15265	COG1960	acyl-CoA dehydrogenase activity
HPK19_15270	COG0183	Belongs to the thiolase family
HPK19_15275	COG1024	Enoyl-CoA hydratase
HPK19_15275	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPK19_15285	COG0506	proline dehydrogenase activity
HPK19_15295	COG2116	formate transmembrane transporter activity
HPK19_15300	COG2755	lipolytic protein G-D-S-L family
HPK19_15305	COG1131	(ABC) transporter
HPK19_15310	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPK19_15315	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPK19_15330	COG3844	kynureninase activity
HPK19_15345	COG1131	(ABC) transporter
HPK19_15365	COG1131	(ABC) transporter
HPK19_15380	COG1611	Belongs to the LOG family
HPK19_15385	COG0673	inositol 2-dehydrogenase activity
HPK19_15400	COG0488	(ABC) transporter
HPK19_15410	COG0024	Methionine aminopeptidase
HPK19_15430	COG1971	Probably functions as a manganese efflux pump
HPK19_15435	COG0805	protein transport
HPK19_15440	COG1120	ATPase activity
HPK19_15445	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK19_15450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK19_15455	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HPK19_15460	COG3853	Toxic anion resistance protein (TelA)
HPK19_15475	COG2310	stress, protein
HPK19_15480	COG2310	stress, protein
HPK19_15495	COG0701	Predicted permease
HPK19_15500	COG3689	TIGRFAM TIGR03943 family protein
HPK19_15515	COG4549	nuclear export factor GLE1
HPK19_15530	COG3546	catalase activity
HPK19_15545	COG1231	oxidoreductase activity
HPK19_15550	COG0346	lactoylglutathione lyase activity
HPK19_15555	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPK19_15560	COG4988	ABC transporter
HPK19_15565	COG1294	oxidase, subunit
HPK19_15570	COG1271	oxidase subunit
HPK19_15575	COG2059	Chromate
HPK19_15580	COG2059	Chromate
HPK19_15590	COG4608	Belongs to the ABC transporter superfamily
HPK19_15595	COG0444	Belongs to the ABC transporter superfamily
HPK19_15615	COG1522	sequence-specific DNA binding
HPK19_15620	COG1511	domain protein
HPK19_15630	COG1115	amino acid carrier protein
HPK19_15635	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_15640	COG2814	Major facilitator Superfamily
HPK19_15645	COG1309	transcriptional regulator
HPK19_15655	COG1404	Belongs to the peptidase S8 family
HPK19_15730	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPK19_15735	COG0557	exoribonuclease II activity
HPK19_15740	COG1647	Serine aminopeptidase, S33
HPK19_15745	COG2318	DinB family
HPK19_15755	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPK19_15780	COG0248	Ppx GppA phosphatase
HPK19_15800	COG0149	triose-phosphate isomerase activity
HPK19_15805	COG0126	phosphoglycerate kinase activity
HPK19_15810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPK19_15825	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPK19_15830	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HPK19_15830	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPK19_15840	COG1486	melibiose metabolic process
HPK19_15845	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPK19_15850	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_15860	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPK19_15865	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_15890	COG2723	6-phospho-beta-galactosidase activity
HPK19_15900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK19_15905	COG1481	regulation of sporulation
HPK19_15910	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPK19_15920	COG1051	belongs to the nudix hydrolase family
HPK19_15925	COG0492	ferredoxin-NADP+ reductase activity
HPK19_15935	COG0110	maltose O-acetyltransferase activity
HPK19_15945	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPK19_15950	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPK19_15955	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HPK19_15965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPK19_15970	COG0556	nucleotide-excision repair
HPK19_15985	COG1131	(ABC) transporter
HPK19_15990	COG1725	Transcriptional regulator
HPK19_16005	COG1595	DNA-templated transcription, initiation
HPK19_16010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPK19_16015	COG0400	carboxylic ester hydrolase activity
HPK19_16020	COG0346	lactoylglutathione lyase activity
HPK19_16045	COG2217	Heavy metal translocating P-type atpase
HPK19_16055	COG0492	ferredoxin-NADP+ reductase activity
HPK19_16085	COG2910	NAD(P)H-binding
HPK19_16090	COG1959	2 iron, 2 sulfur cluster binding
HPK19_16100	COG1522	sequence-specific DNA binding
HPK19_16110	COG0346	lactoylglutathione lyase activity
HPK19_16115	COG0431	NADPH-dependent FMN reductase
HPK19_16120	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPK19_16125	COG2197	response regulator
HPK19_16130	COG4585	Histidine kinase
HPK19_16130	COG2203	Gaf domain
HPK19_16140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK19_16155	COG3186	Phenylalanine-4-hydroxylase
HPK19_16165	COG1268	BioY protein
HPK19_16185	COG0745	RESPONSE REGULATOR receiver
HPK19_16190	COG2205	protein histidine kinase activity
HPK19_16195	COG0577	efflux transmembrane transporter activity
HPK19_16200	COG1136	(ABC) transporter
HPK19_16205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPK19_16210	COG1024	Enoyl-CoA hydratase
HPK19_16215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPK19_16225	COG0439	Biotin carboxylase
HPK19_16230	COG1960	acyl-CoA dehydrogenase activity
HPK19_16240	COG1309	transcriptional regulator
HPK19_16255	COG0352	thiamine-phosphate diphosphorylase activity
HPK19_16260	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HPK19_16270	COG0351	phosphomethylpyrimidine kinase
HPK19_16280	COG0672	)-iron permease
HPK19_16285	COG1011	Hydrolase
HPK19_16310	COG0133	tryptophan synthase activity
HPK19_16315	COG0135	phosphoribosylanthranilate isomerase activity
HPK19_16320	COG0134	indole-3-glycerol-phosphate synthase activity
HPK19_16325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPK19_16330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPK19_16330	COG0512	Glutamine amidotransferase of anthranilate synthase
HPK19_16335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPK19_16340	COG0697	spore germination
HPK19_16355	COG1392	Phosphate transport regulator
HPK19_16365	COG0300	oxidoreductase activity
HPK19_16370	COG0583	DNA-binding transcription factor activity
HPK19_16380	COG2252	PERMEase
HPK19_16385	COG1187	pseudouridine synthase activity
HPK19_16395	COG1404	Belongs to the peptidase S8 family
HPK19_16405	COG0246	Mannitol dehydrogenase
HPK19_16410	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK19_16415	COG3711	transcriptional antiterminator
HPK19_16425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPK19_16430	COG0793	Belongs to the peptidase S41A family
HPK19_16430	COG3409	Peptidoglycan-binding domain 1 protein
HPK19_16435	COG0753	catalase activity
HPK19_16440	COG0739	heme binding
HPK19_16445	COG2177	Part of the ABC transporter FtsEX involved in
HPK19_16450	COG2884	Cell division ATP-binding protein ftsE
HPK19_16460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPK19_16480	COG1278	Cold shock
HPK19_16485	COG0531	amino acid
HPK19_16495	COG1040	competence protein
HPK19_16500	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HPK19_16505	COG1307	EDD domain protein, DegV family
HPK19_16510	COG2197	response regulator
HPK19_16520	COG1316	TRANSCRIPTIONal
HPK19_16525	COG1739	Uncharacterized protein family UPF0029
HPK19_16530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPK19_16545	COG0741	lytic transglycosylase activity
HPK19_16560	COG0653	protein targeting
HPK19_16620	COG1316	TRANSCRIPTIONal
HPK19_16635	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPK19_16650	COG1132	(ABC) transporter
HPK19_16655	COG1396	sequence-specific DNA binding
HPK19_16660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPK19_16665	COG0110	maltose O-acetyltransferase activity
HPK19_16670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPK19_16680	COG1216	Glycosyl transferase, family 2
HPK19_16685	COG1215	transferase activity, transferring glycosyl groups
HPK19_16690	COG0438	transferase activity, transferring glycosyl groups
HPK19_16690	COG0297	glycogen (starch) synthase activity
HPK19_16695	COG1442	glycosyl transferase family 8
HPK19_16695	COG1216	Glycosyl transferase, family 2
HPK19_16700	COG0463	Glycosyl transferase, family 2
HPK19_16710	COG0438	transferase activity, transferring glycosyl groups
HPK19_16720	COG0489	protein tyrosine kinase activity
HPK19_16725	COG3944	biosynthesis protein
HPK19_16755	COG1329	Transcriptional regulator
HPK19_16770	COG4715	Zinc finger, swim domain protein
HPK19_16775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPK19_16780	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPK19_16780	COG0456	acetyltransferase
HPK19_16785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPK19_16800	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPK19_16810	COG0697	spore germination
HPK19_16815	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPK19_16825	COG1609	Transcriptional regulator
HPK19_16830	COG0739	heme binding
HPK19_16835	COG4166	transmembrane transport
HPK19_16840	COG2385	sporulation resulting in formation of a cellular spore
HPK19_16855	COG4836	Membrane
HPK19_16860	COG1007	ATP synthesis coupled electron transport
HPK19_16865	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPK19_16870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPK19_16875	COG0713	ATP synthesis coupled electron transport
HPK19_16880	COG0839	Belongs to the complex I subunit 6 family
HPK19_16895	COG0649	NAD binding
HPK19_16900	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPK19_16905	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPK19_16910	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPK19_16915	COG2814	Major facilitator Superfamily
HPK19_16920	COG1566	PFAM secretion protein HlyD family protein
HPK19_16925	COG1309	transcriptional regulator
HPK19_16930	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPK19_16940	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPK19_16945	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPK19_16950	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPK19_16960	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPK19_16965	COG0356	it plays a direct role in the translocation of protons across the membrane
HPK19_16980	COG1404	Belongs to the peptidase S8 family
HPK19_16990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPK19_17000	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPK19_17005	COG2390	Transcriptional regulator
HPK19_17010	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPK19_17030	COG0698	ribose 5-phosphate isomerase
HPK19_17045	COG0009	L-threonylcarbamoyladenylate synthase
HPK19_17060	COG0189	ligase activity
HPK19_17070	COG2890	protein-(glutamine-N5) methyltransferase activity
HPK19_17075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPK19_17080	COG1435	thymidine kinase activity
HPK19_17090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPK19_17095	COG1494	fructose-1,6-bisphosphatase
HPK19_17115	COG4821	SIS domain
HPK19_17120	COG0504	CTP synthase activity
HPK19_17125	COG3343	RNA polymerase activity
HPK19_17130	COG1703	isobutyryl-CoA mutase activity
HPK19_17130	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPK19_17130	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPK19_17135	COG1960	acyl-CoA dehydrogenase activity
HPK19_17140	COG0183	Belongs to the thiolase family
HPK19_17145	COG2181	nitrate reductase activity
HPK19_17145	COG0247	lactate metabolic process
HPK19_17150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPK19_17170	COG1191	sigma factor activity
HPK19_17195	COG2814	Major facilitator Superfamily
HPK19_17200	COG0789	Transcriptional regulator
HPK19_17215	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HPK19_17220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPK19_17230	COG1994	Peptidase M50
HPK19_17240	COG1078	dGTPase activity
HPK19_17245	COG4844	belongs to the
HPK19_17255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPK19_17260	COG0095	Lipoate-protein ligase
HPK19_17265	COG0280	phosphate acetyltransferase
HPK19_17275	COG3773	Cell wall hydrolase
HPK19_17285	COG2363	Small membrane protein
HPK19_17295	COG0561	phosphatase activity
HPK19_17300	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPK19_17305	COG2855	membrane
HPK19_17310	COG0463	Glycosyl transferase, family 2
HPK19_17325	COG1131	(ABC) transporter
HPK19_17345	COG0551	DNA topoisomerase type I activity
HPK19_17345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPK19_17350	COG1376	ErfK ybiS ycfS ynhG family protein
HPK19_17360	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPK19_17365	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPK19_17370	COG2188	Transcriptional regulator
HPK19_17375	COG0366	Alpha amylase catalytic
HPK19_17380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK19_17380	COG1263	PTS System
HPK19_17425	COG0720	synthase
HPK19_17435	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPK19_17440	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HPK19_17445	COG1309	transcriptional regulator
HPK19_17455	COG0745	RESPONSE REGULATOR receiver
HPK19_17460	COG0642	Histidine kinase
HPK19_17465	COG1136	(ABC) transporter
HPK19_17470	COG0577	efflux transmembrane transporter activity
HPK19_17480	COG2879	small protein
HPK19_17485	COG1966	Carbon starvation protein
HPK19_17490	COG1309	transcriptional regulator
HPK19_17495	COG2814	Major facilitator Superfamily
HPK19_17505	COG3507	Belongs to the glycosyl hydrolase 43 family
HPK19_17510	COG0667	Aldo Keto reductase
HPK19_17515	COG1070	Carbohydrate kinase
HPK19_17525	COG2017	converts alpha-aldose to the beta-anomer
HPK19_17530	COG5578	integral membrane protein
HPK19_17535	COG0395	ABC-type sugar transport system, permease component
HPK19_17550	COG2207	Transcriptional regulator
HPK19_17550	COG4753	response regulator
HPK19_17555	COG2972	Histidine kinase
HPK19_17565	COG1263	PTS System
HPK19_17565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK19_17595	COG3973	AAA domain
HPK19_17600	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPK19_17620	COG2222	sugar isomerase
HPK19_17625	COG2188	Transcriptional regulator
HPK19_17630	COG0673	inositol 2-dehydrogenase activity
HPK19_17635	COG0395	ABC-type sugar transport system, permease component
HPK19_17640	COG1175	transmembrane transport
HPK19_17650	COG0579	oxidoreductase
HPK19_17665	COG5002	protein histidine kinase activity
HPK19_17685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK19_17685	COG1263	PTS System
HPK19_17705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPK19_17715	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HPK19_17720	COG4853	Protein conserved in bacteria
HPK19_17725	COG4863	YycH protein
HPK19_17730	COG5002	protein histidine kinase activity
HPK19_17735	COG0745	RESPONSE REGULATOR receiver
HPK19_17760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPK19_17765	COG0305	Participates in initiation and elongation during chromosome replication
HPK19_17770	COG0359	binds to the 23S rRNA
HPK19_17775	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HPK19_17795	COG0360	Binds together with S18 to 16S ribosomal RNA
HPK19_17800	COG0012	GTP binding
HPK19_17805	COG4481	Protein conserved in bacteria
HPK19_17810	COG0668	transmembrane transport
HPK19_17820	COG1475	DNA binding
HPK19_17825	COG1192	Involved in chromosome partitioning
HPK19_17840	COG0445	tRNA wobble uridine modification
HPK19_17845	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPK19_17850	COG1847	R3H domain protein
HPK19_17865	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPK19_17870	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPK19_17875	COG0592	DNA-directed DNA polymerase activity
HPK19_17880	COG2501	S4 domain
HPK19_17890	COG0187	DNA topoisomerase II activity
HPK19_17895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPK19_17915	COG1132	(ABC) transporter
HPK19_17920	COG0745	RESPONSE REGULATOR receiver
HPK19_17925	COG5002	protein histidine kinase activity
HPK19_17950	COG0517	IMP dehydrogenase activity
HPK19_17950	COG0516	GMP reductase activity
HPK19_17960	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HPK19_17965	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HPK19_17970	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPK19_17980	COG1428	Deoxynucleoside kinase
HPK19_17985	COG1428	Deoxynucleoside kinase
HPK19_17990	COG1335	isochorismatase
HPK19_17995	COG0590	tRNA wobble adenosine to inosine editing
HPK19_18005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPK19_18010	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPK19_18015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPK19_18060	COG1982	Orn Lys Arg decarboxylase major
HPK19_18065	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPK19_18070	COG0470	DNA polymerase III
HPK19_18075	COG1774	PSP1 C-terminal conserved region
HPK19_18080	COG4467	Involved in initiation control of chromosome replication
HPK19_18085	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HPK19_18090	COG2827	Endonuclease containing a URI domain
HPK19_18095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPK19_18100	COG2002	toxin-antitoxin pair type II binding
HPK19_18105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPK19_18105	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPK19_18110	COG0084	hydrolase, TatD family'
HPK19_18115	COG3584	3D domain protein
HPK19_18115	COG3583	domain protein
HPK19_18135	COG4466	Protein conserved in bacteria
HPK19_18150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPK19_18155	COG0251	oxidation-reduction process
HPK19_18160	COG2088	sporulation resulting in formation of a cellular spore
HPK19_18165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPK19_18185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPK19_18190	COG2002	toxin-antitoxin pair type II binding
HPK19_18195	COG2244	polysaccharide biosynthetic process
HPK19_18200	COG3956	TIGRFAM MazG family protein
HPK19_18205	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPK19_18225	COG1098	S1 RNA binding domain
HPK19_18240	COG2208	phosphoserine phosphatase activity
HPK19_18245	COG2304	oxidoreductase activity
HPK19_18250	COG0515	serine threonine protein kinase
HPK19_18265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPK19_18280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPK19_18285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPK19_18290	COG0512	Glutamine amidotransferase of anthranilate synthase
HPK19_18295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPK19_18300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPK19_18305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPK19_18310	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPK19_18315	COG1396	sequence-specific DNA binding
HPK19_18320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPK19_18325	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPK19_18420	COG3880	PFAM UvrB UvrC protein
HPK19_18425	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HPK19_18430	COG0542	response to heat
HPK19_18435	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPK19_18445	COG4956	integral membrane protein (PIN domain superfamily)
HPK19_18450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPK19_18455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPK19_18460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPK19_18465	COG1045	serine acetyltransferase
HPK19_18470	COG0215	cysteine-tRNA ligase activity
HPK19_18480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPK19_18485	COG3688	RNA-binding protein containing a PIN domain
HPK19_18500	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPK19_18505	COG0250	Participates in transcription elongation, termination and antitermination
HPK19_18510	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPK19_18515	COG0081	regulation of translation
HPK19_18520	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPK19_18525	COG0222	ribosome binding
HPK19_18530	COG2813	Specifically methylates the guanine in position
HPK19_18550	COG0049	tRNA binding
HPK19_18560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPK19_18565	COG0051	transcription antitermination factor activity, RNA binding
HPK19_18570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPK19_18575	COG0088	Forms part of the polypeptide exit tunnel
HPK19_18580	COG0089	rRNA binding
HPK19_18595	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPK19_18600	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPK19_18615	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPK19_18620	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPK19_18635	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPK19_18645	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPK19_18650	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPK19_18655	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPK19_18660	COG1841	ribosomal large subunit assembly
HPK19_18670	COG0201	protein transport
HPK19_18675	COG0563	adenylate kinase activity
HPK19_18685	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPK19_18690	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPK19_18720	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPK19_18725	COG0101	tRNA pseudouridine synthase activity
HPK19_18730	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPK19_18745	COG1027	Aspartate ammonia-lyase
HPK19_18750	COG0281	malic enzyme
HPK19_18755	COG4191	Histidine kinase
HPK19_18760	COG0784	Response regulator, receiver
HPK19_18780	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPK19_18785	COG0489	protein tyrosine kinase activity
HPK19_18790	COG2194	sulfuric ester hydrolase activity
HPK19_18795	COG0726	polysaccharide deacetylase
HPK19_18870	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HPK19_18880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPK19_18890	COG0697	spore germination
HPK19_18915	COG0745	RESPONSE REGULATOR receiver
HPK19_18920	COG5002	protein histidine kinase activity
HPK19_18925	COG1803	Methylglyoxal synthase
HPK19_18935	COG1733	regulation of RNA biosynthetic process
HPK19_18940	COG2814	Major facilitator Superfamily
HPK19_18945	COG0656	L-ascorbic acid biosynthetic process
HPK19_18950	COG2801	Transposase and inactivated derivatives
HPK19_18975	COG2259	Doxx family
HPK19_18990	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPK19_18995	COG0019	diaminopimelate decarboxylase activity
HPK19_19000	COG1388	LysM domain
HPK19_19000	COG0791	NLP P60 protein
HPK19_19005	COG1970	mechanosensitive ion channel activity
HPK19_19010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPK19_19010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPK19_19025	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPK19_19030	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPK19_19035	COG0513	Belongs to the DEAD box helicase family
HPK19_19040	COG4294	response to UV
HPK19_19050	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPK19_19055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPK19_19060	COG0864	Transcriptional regulator
HPK19_19065	COG2337	Toxic component of a toxin-antitoxin (TA) module
HPK19_19070	COG2183	response to ionizing radiation
HPK19_19080	COG3091	SprT-like family
HPK19_19180	COG0802	atpase or kinase
HPK19_19185	COG1214	PFAM Peptidase M22, glycoprotease
HPK19_19190	COG0456	acetyltransferase
HPK19_19195	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPK19_19200	COG0488	(ABC) transporter
HPK19_19210	COG1266	CAAX protease self-immunity
HPK19_19215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPK19_19220	COG0459	protein refolding
HPK19_19230	COG0582	viral genome integration into host DNA
HPK19_19235	COG3620	sequence-specific DNA binding
HPK19_19255	COG3645	SOS response
HPK19_19255	COG3646	Phage regulatory protein
HPK19_19305	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HPK19_19355	COG1802	Transcriptional regulator
HPK19_19355	COG4626	Terminase
HPK19_19425	COG3953	SLT domain
HPK19_19425	COG5280	Phage tail tape measure protein TP901
HPK19_19455	COG5632	N-Acetylmuramoyl-L-alanine amidase
HPK19_19515	COG0739	heme binding
HPK19_19540	COG5632	N-Acetylmuramoyl-L-alanine amidase
HPK19_19545	COG2076	Multidrug Resistance protein
HPK19_19575	COG2252	PERMEase
HPK19_19615	COG1193	negative regulation of DNA recombination
HPK19_19620	COG2226	methyltransferase
HPK19_19635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_19640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_19645	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPK19_19650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK19_19650	COG3711	transcriptional antiterminator
HPK19_19720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK19_19730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPK19_19735	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPK19_19740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPK19_19745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPK19_19750	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPK19_19755	COG0047	phosphoribosylformylglycinamidine synthase activity
HPK19_19765	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPK19_19770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPK19_19775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPK19_19785	COG0151	Belongs to the GarS family
HPK19_19795	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HPK19_19800	COG0210	DNA helicase
HPK19_19810	COG4851	CamS sex pheromone cAM373 precursor
HPK19_19815	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_19825	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPK19_19835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPK19_19840	COG2116	formate transmembrane transporter activity
HPK19_19845	COG1597	lipid kinase activity
HPK19_19855	COG4412	M6 family metalloprotease domain protein
HPK19_19855	COG1404	Belongs to the peptidase S8 family
HPK19_19875	COG4821	SIS domain
HPK19_19890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_19900	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_19905	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPK19_19910	COG1486	melibiose metabolic process
HPK19_19920	COG0531	amino acid
HPK19_19925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPK19_19940	COG1414	Transcriptional regulator
HPK19_19955	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_19960	COG0028	Belongs to the TPP enzyme family
HPK19_19970	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HPK19_19975	COG4638	Rieske (2fe-2S)
HPK19_19985	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_20000	COG1657	PFAM Prenyltransferase squalene oxidase
HPK19_20005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPK19_20010	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPK19_20015	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPK19_20020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPK19_20025	COG0456	acetyltransferase
HPK19_20030	COG3829	transcription factor binding
HPK19_20035	COG1509	lysine 2,3-aminomutase activity
HPK19_20045	COG0833	amino acid
HPK19_20055	COG3711	transcriptional antiterminator
HPK19_20060	COG1263	PTS System
HPK19_20060	COG2190	(PTS) system
HPK19_20060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK19_20075	COG0531	amino acid
HPK19_20080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPK19_20095	COG3290	protein histidine kinase activity
HPK19_20095	COG3829	transcription factor binding
HPK19_20100	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_20110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPK19_20115	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_20120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPK19_20125	COG1960	acyl-CoA dehydrogenase activity
HPK19_20155	COG1294	oxidase, subunit
HPK19_20160	COG1271	oxidase subunit
HPK19_20170	COG0492	ferredoxin-NADP+ reductase activity
HPK19_20175	COG1120	ATPase activity
HPK19_20180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPK19_20185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK19_20190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK19_20195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPK19_20200	COG2199	diguanylate cyclase activity
HPK19_20200	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPK19_20240	COG1876	peptidase activity
HPK19_20250	COG1404	Belongs to the peptidase S8 family
HPK19_20255	COG2755	lipolytic protein G-D-S-L family
HPK19_20255	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HPK19_20265	COG1595	DNA-templated transcription, initiation
HPK19_20270	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HPK19_20275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK19_20295	COG0534	Mate efflux family protein
HPK19_20300	COG1271	oxidase subunit
HPK19_20305	COG1294	oxidase, subunit
HPK19_20310	COG1126	abc transporter atp-binding protein
HPK19_20315	COG0765	amino acid transport
HPK19_20320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK19_20335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HPK19_20345	COG3852	Histidine kinase
HPK19_20350	COG1408	metallophosphoesterase
HPK19_20385	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPK19_20390	COG1609	Transcriptional regulator
HPK19_20395	COG0077	Prephenate dehydratase
HPK19_20405	COG3829	transcription factor binding
HPK19_20410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPK19_20415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPK19_20420	COG0833	amino acid
HPK19_20430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPK19_20435	COG0601	transmembrane transport
HPK19_20440	COG4608	Belongs to the ABC transporter superfamily
HPK19_20450	COG0783	Belongs to the Dps family
HPK19_20460	COG3859	Proton-coupled thiamine transporter YuaJ
HPK19_20465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPK19_20475	COG1295	ribonuclease BN
HPK19_20480	COG2217	Heavy metal translocating P-type atpase
HPK19_20490	COG0697	spore germination
HPK19_20510	COG0791	NLP P60 protein
HPK19_20510	COG1388	LysM domain
HPK19_20515	COG3152	Membrane
HPK19_20525	COG3152	Membrane
HPK19_20580	COG2972	Histidine kinase
HPK19_20585	COG2207	Transcriptional regulator
HPK19_20585	COG4753	response regulator
HPK19_20590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPK19_20600	COG0745	RESPONSE REGULATOR receiver
HPK19_20610	COG3944	biosynthesis protein
HPK19_20615	COG0489	protein tyrosine kinase activity
HPK19_20625	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPK19_20630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPK19_20650	COG1216	Glycosyl transferase, family 2
HPK19_20655	COG5039	Polysaccharide pyruvyl transferase
HPK19_20665	COG0438	transferase activity, transferring glycosyl groups
HPK19_20725	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPK19_20730	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPK19_20735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPK19_20740	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HPK19_20740	COG1215	transferase activity, transferring glycosyl groups
HPK19_20750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HPK19_20750	COG1215	transferase activity, transferring glycosyl groups
HPK19_20765	COG1216	Glycosyl transferase, family 2
HPK19_20765	COG1442	glycosyl transferase family 8
HPK19_20770	COG1215	transferase activity, transferring glycosyl groups
HPK19_20770	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HPK19_20775	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPK19_20780	COG1682	transport, permease protein
HPK19_20785	COG1134	teichoic acid transport
HPK19_20790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPK19_20805	COG3871	stress protein (general stress protein 26)
HPK19_20810	COG0387	Pfam Sodium calcium exchanger
HPK19_20815	COG2364	Membrane
HPK19_20825	COG0535	radical SAM domain protein
HPK19_20850	COG1216	Glycosyl transferase, family 2
HPK19_20850	COG1442	glycosyl transferase family 8
HPK19_20855	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPK19_20860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPK19_20865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPK19_20890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPK19_20900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPK19_20905	COG0573	inorganic phosphate transmembrane transporter activity
HPK19_20910	COG0581	inorganic phosphate transmembrane transporter activity
HPK19_20930	COG5002	protein histidine kinase activity
HPK19_20935	COG0745	RESPONSE REGULATOR receiver
HPK19_20940	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPK19_20945	COG0463	Glycosyl transferase, family 2
HPK19_20955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPK19_20960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPK19_20970	COG1132	(ABC) transporter
HPK19_20975	COG1132	(ABC) transporter
HPK19_20980	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPK19_20990	COG2972	Histidine kinase
HPK19_20995	COG3279	Response regulator of the LytR AlgR family
HPK19_21010	COG4214	carbohydrate transport
HPK19_21040	COG0277	FAD linked oxidase domain protein
HPK19_21045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPK19_21050	COG3153	acetyltransferase
HPK19_21050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPK19_21055	COG0456	acetyltransferase
HPK19_21075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPK19_21095	COG1607	acyl-coa hydrolase
HPK19_21105	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPK19_21110	COG0697	spore germination
HPK19_21140	COG2959	enzyme of heme biosynthesis
HPK19_21150	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_21155	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_21160	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPK19_21165	COG1486	melibiose metabolic process
HPK19_21185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPK19_21190	COG1132	(ABC) transporter
HPK19_21205	COG0456	acetyltransferase
HPK19_21205	COG1846	Transcriptional regulator
HPK19_21210	COG0861	Integral membrane protein TerC family
HPK19_21225	COG5566	PFAM Mor transcription activator
HPK19_21240	COG1473	amidohydrolase
HPK19_21270	COG1486	melibiose metabolic process
HPK19_21275	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPK19_21280	COG2971	BadF BadG BcrA BcrD
HPK19_21290	COG1737	Transcriptional regulator
HPK19_21295	COG1278	Cold shock
HPK19_21305	COG0247	lactate metabolic process
HPK19_21310	COG0277	FAD linked oxidase domain protein
HPK19_21315	COG3835	regulator
HPK19_21325	COG2814	Major facilitator Superfamily
HPK19_21330	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HPK19_21335	COG1263	PTS System
HPK19_21335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK19_21340	COG1737	Transcriptional regulator
HPK19_21365	COG1737	Transcriptional regulator
HPK19_21385	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPK19_21395	COG1554	hydrolase, family 65, central catalytic
HPK19_21400	COG0346	lactoylglutathione lyase activity
HPK19_21410	COG1470	cell adhesion involved in biofilm formation
HPK19_21415	COG1357	PFAM Pentapeptide repeats (8 copies)
HPK19_21430	COG0697	spore germination
HPK19_21450	COG1404	Belongs to the peptidase S8 family
HPK19_21460	COG2066	Belongs to the glutaminase family
HPK19_21475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPK19_21480	COG0628	permease
HPK19_21485	COG1368	sulfuric ester hydrolase activity
HPK19_21490	COG4548	von Willebrand factor, type A
HPK19_21495	COG0714	Associated with various cellular activities
HPK19_21505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPK19_21525	COG1228	amidohydrolase
HPK19_21530	COG1090	epimerase
HPK19_21555	COG1988	membrane-bound metal-dependent
HPK19_21560	COG1194	a g-specific adenine glycosylase
HPK19_21580	COG3557	Belongs to the UPF0374 family
HPK19_21585	COG1132	(ABC) transporter
HPK19_21590	COG4129	membrane
HPK19_21595	COG0070	glutamate synthase
HPK19_21595	COG0067	glutamate synthase
HPK19_21595	COG0069	glutamate synthase activity
HPK19_21600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPK19_21605	COG4555	ABC transporter
HPK19_21625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPK19_21630	COG0735	belongs to the Fur family
HPK19_21775	COG2169	Transcriptional regulator
HPK19_21795	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPK19_21800	COG0297	glycogen (starch) synthase activity
HPK19_21805	COG0058	SHG alpha-glucan phosphorylase activity
HPK19_21830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPK19_21835	COG1575	Belongs to the MenA family. Type 1 subfamily
HPK19_21840	COG1169	isochorismate synthase
HPK19_21845	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPK19_21850	COG0596	Alpha beta hydrolase
HPK19_21855	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPK19_21860	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_21865	COG4948	Mandelate Racemase Muconate Lactonizing
HPK19_21870	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HPK19_21880	COG0494	nUDIX hydrolase
HPK19_21885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPK19_21890	COG1116	anion transmembrane transporter activity
HPK19_21895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPK19_21900	COG1959	2 iron, 2 sulfur cluster binding
HPK19_21905	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPK19_21965	COG1741	Belongs to the pirin family
HPK19_21970	COG1765	OsmC-like protein
HPK19_21980	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HPK19_21990	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HPK19_21995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPK19_21995	COG0438	transferase activity, transferring glycosyl groups
HPK19_22000	COG0671	phosphoesterase, PA-phosphatase related
HPK19_22005	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPK19_22015	COG0477	Major facilitator Superfamily
HPK19_22020	COG0475	glutathione-regulated potassium exporter activity
HPK19_22030	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HPK19_22035	COG1242	4 iron, 4 sulfur cluster binding
HPK19_22050	COG2814	Major facilitator Superfamily
HPK19_22060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK19_22070	COG2081	HI0933 family
HPK19_22075	COG2244	polysaccharide biosynthetic process
HPK19_22080	COG1187	pseudouridine synthase activity
HPK19_22085	COG1349	DNA-binding transcription factor activity
HPK19_22090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPK19_22105	COG1523	belongs to the glycosyl hydrolase 13 family
HPK19_22110	COG0510	thiamine kinase activity
HPK19_22125	COG2226	methyltransferase
HPK19_22135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_22145	COG1363	Peptidase, m42
HPK19_22155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPK19_22160	COG4848	Belongs to the UPF0354 family
HPK19_22165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPK19_22170	COG1674	ftsk spoiiie
HPK19_22180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPK19_22190	COG0477	Major facilitator Superfamily
HPK19_22195	COG2986	histidine ammonia-lyase
HPK19_22200	COG4977	sequence-specific DNA binding
HPK19_22225	COG2814	Major facilitator Superfamily
HPK19_22230	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HPK19_22235	COG1793	dna ligase
HPK19_22240	COG1793	dna ligase
HPK19_22240	COG3285	dna ligase
HPK19_22245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPK19_22260	COG1404	Belongs to the peptidase S8 family
HPK19_22270	COG1595	DNA-templated transcription, initiation
HPK19_22280	COG3344	reverse transcriptase
HPK19_22300	COG0814	amino acid
HPK19_22305	COG0454	-acetyltransferase
HPK19_22315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPK19_22320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPK19_22325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPK19_22330	COG0640	Transcriptional regulator
HPK19_22350	COG2378	regulation of single-species biofilm formation
HPK19_22355	COG1113	amino acid transport
HPK19_22360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_22375	COG3708	Transcriptional regulator
HPK19_22375	COG2207	Transcriptional regulator
HPK19_22405	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HPK19_22415	COG0492	ferredoxin-NADP+ reductase activity
HPK19_22430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPK19_22440	COG0384	phenazine biosynthesis protein PhzF
HPK19_22445	COG1078	dGTPase activity
HPK19_22455	COG1757	Na H antiporter
HPK19_22470	COG1301	dicarboxylic acid transport
HPK19_22475	COG1802	Transcriptional regulator
HPK19_22490	COG2309	aminopeptidase activity
HPK19_22500	COG3118	belongs to the thioredoxin family
HPK19_22520	COG1605	Chorismate mutase
HPK19_22520	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HPK19_22530	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPK19_22535	COG0517	IMP dehydrogenase activity
HPK19_22540	COG0454	-acetyltransferase
HPK19_22545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPK19_22555	COG1704	LemA family
HPK19_22585	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPK19_22590	COG1956	GAF domain-containing protein
HPK19_22595	COG1309	transcriptional regulator
HPK19_22600	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HPK19_22605	COG1104	cysteine desulfurase activity
HPK19_22625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPK19_22630	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HPK19_22640	COG3874	Sporulation protein YtfJ
HPK19_22645	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HPK19_22650	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPK19_22655	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HPK19_22655	COG0392	lysyltransferase activity
HPK19_22660	COG1215	transferase activity, transferring glycosyl groups
HPK19_22670	COG0827	DNA restriction-modification system
HPK19_22675	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPK19_22680	COG2217	Heavy metal translocating P-type atpase
HPK19_22690	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_22705	COG0006	proline dipeptidase activity
HPK19_22715	COG4109	DRTGG domain
HPK19_22730	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPK19_22745	COG0587	DNA-directed DNA polymerase activity
HPK19_22750	COG0281	malic enzyme
HPK19_22760	COG0825	malonyl-CoA metabolic process
HPK19_22765	COG0205	6-phosphofructokinase activity
HPK19_22785	COG0628	permease
HPK19_22795	COG0372	Belongs to the citrate synthase family
HPK19_22800	COG0538	isocitrate dehydrogenase activity
HPK19_22805	COG0039	L-malate dehydrogenase activity
HPK19_22820	COG0745	RESPONSE REGULATOR receiver
HPK19_22825	COG5002	protein histidine kinase activity
HPK19_22835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPK19_22835	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPK19_22845	COG1971	Probably functions as a manganese efflux pump
HPK19_22855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPK19_22860	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HPK19_22865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPK19_22870	COG3611	Membrane attachment protein
HPK19_22875	COG1484	DNA-dependent DNA replication
HPK19_22895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPK19_22905	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HPK19_22910	COG1363	Peptidase, m42
HPK19_22915	COG4175	Glycine betaine
HPK19_22915	COG0517	IMP dehydrogenase activity
HPK19_22920	COG2113	Glycine betaine
HPK19_22930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPK19_22935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPK19_22960	COG1216	Glycosyl transferase, family 2
HPK19_22965	COG0463	Glycosyl transferase, family 2
HPK19_22965	COG0457	Tetratricopeptide repeat
HPK19_22970	COG0463	Glycosyl transferase, family 2
HPK19_22970	COG0457	Tetratricopeptide repeat
HPK19_22975	COG0018	arginyl-trna synthetase
HPK19_22980	COG0778	Nitroreductase
HPK19_22985	COG0488	(ABC) transporter
HPK19_23015	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPK19_23025	COG1286	toxin biosynthetic process
HPK19_23030	COG1796	DNA polymerase
HPK19_23030	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPK19_23035	COG1193	negative regulation of DNA recombination
HPK19_23045	COG0456	acetyltransferase
HPK19_23075	COG4152	abc transporter atp-binding protein
HPK19_23080	COG1668	transmembrane transport
HPK19_23100	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_23105	COG1309	transcriptional regulator
HPK19_23110	COG1024	Enoyl-CoA hydratase
HPK19_23115	COG2086	electron transfer activity
HPK19_23120	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HPK19_23140	COG3118	belongs to the thioredoxin family
HPK19_23145	COG1846	Transcriptional regulator
HPK19_23150	COG0477	Major facilitator Superfamily
HPK19_23160	COG0322	excinuclease ABC activity
HPK19_23175	COG1719	4-vinyl reductase, 4VR
HPK19_23180	COG2009	succinate dehydrogenase
HPK19_23185	COG1053	succinate dehydrogenase
HPK19_23190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPK19_23210	COG0824	Thioesterase
HPK19_23215	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPK19_23235	COG1959	2 iron, 2 sulfur cluster binding
HPK19_23245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPK19_23255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPK19_23265	COG0084	hydrolase, TatD family'
HPK19_23270	COG2197	response regulator
HPK19_23275	COG5401	PFAM Sporulation and spore germination
HPK19_23280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPK19_23285	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPK19_23290	COG0622	Phosphoesterase
HPK19_23310	COG1477	protein flavinylation
HPK19_23310	COG0457	Tetratricopeptide repeat
HPK19_23315	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPK19_23325	COG1067	ATP-dependent peptidase activity
HPK19_23325	COG0470	DNA polymerase III
HPK19_23345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPK19_23350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPK19_23365	COG0113	porphobilinogen synthase activity
HPK19_23370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPK19_23375	COG1388	LysM domain
HPK19_23375	COG1388	LysM domain
HPK19_23380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPK19_23385	COG4326	sporulation control protein
HPK19_23395	COG0285	dihydrofolate synthase activity
HPK19_23400	COG2199	diguanylate cyclase activity
HPK19_23420	COG1077	Cell shape determining protein MreB Mrl
HPK19_23425	COG1792	Involved in formation and maintenance of cell shape
HPK19_23430	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPK19_23435	COG0850	regulation of cytokinetic process
HPK19_23440	COG2894	cell division
HPK19_23445	COG0739	heme binding
HPK19_23450	COG1994	Peptidase M50
HPK19_23455	COG1216	Glycosyl transferase, family 2
HPK19_23460	COG1530	ribonuclease E activity
HPK19_23465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPK19_23470	COG2868	ribosomal protein
HPK19_23475	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPK19_23480	COG3290	protein histidine kinase activity
HPK19_23490	COG1827	regulation of RNA biosynthetic process
HPK19_23495	COG1104	cysteine desulfurase activity
HPK19_23500	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPK19_23505	COG0157	Belongs to the NadC ModD family
HPK19_23525	COG1309	transcriptional regulator
HPK19_23540	COG0667	Aldo Keto reductase
HPK19_23555	COG2267	carboxylic ester hydrolase activity
HPK19_23595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK19_23615	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPK19_23625	COG1862	Preprotein translocase
HPK19_23635	COG2323	membrane
HPK19_23640	COG2244	polysaccharide biosynthetic process
HPK19_23650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPK19_23650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPK19_23655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPK19_23660	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPK19_23660	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HPK19_23665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPK19_23670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPK19_23695	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPK19_23700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPK19_23720	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPK19_23745	COG1404	Belongs to the peptidase S8 family
HPK19_23750	COG1959	2 iron, 2 sulfur cluster binding
HPK19_23755	COG1104	cysteine desulfurase activity
HPK19_23760	COG0482	sulfurtransferase activity
HPK19_23770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPK19_23785	COG0628	permease
HPK19_23795	COG4472	Bacterial protein of unknown function (DUF965)
HPK19_23800	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPK19_23805	COG3906	Belongs to the UPF0473 family
HPK19_23810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPK19_23815	COG4122	O-methyltransferase activity
HPK19_23840	COG0768	penicillin binding
HPK19_23855	COG1131	(ABC) transporter
HPK19_23860	COG0842	Transport permease protein
HPK19_23860	COG1511	domain protein
HPK19_23865	COG1309	transcriptional regulator
HPK19_23880	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HPK19_23880	COG1605	Chorismate mutase
HPK19_23885	COG0287	Prephenate dehydrogenase
HPK19_23905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPK19_23910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPK19_23920	COG2357	RelA SpoT domain protein
HPK19_23935	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HPK19_23940	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HPK19_23950	COG1534	Rna-binding protein
HPK19_23955	COG1713	HD superfamily hydrolase involved in NAD metabolism
HPK19_23960	COG0799	negative regulation of ribosome biogenesis
HPK19_23965	COG2226	methyltransferase
HPK19_23970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPK19_23980	COG0658	competence protein
HPK19_23980	COG2333	competence protein COMEC
HPK19_23990	COG1466	dna polymerase III delta subunit
HPK19_24000	COG0268	Binds directly to 16S ribosomal RNA
HPK19_24015	COG0481	GTPase activity
HPK19_24020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPK19_24030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPK19_24040	COG0484	heat shock protein binding
HPK19_24050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPK19_24055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPK19_24070	COG1309	transcriptional regulator
HPK19_24085	COG2207	Transcriptional regulator
HPK19_24090	COG2972	Histidine kinase
HPK19_24095	COG4608	Belongs to the ABC transporter superfamily
HPK19_24100	COG0444	Belongs to the ABC transporter superfamily
HPK19_24115	COG0747	negative chemotaxis
HPK19_24120	COG0402	S-adenosylhomocysteine deaminase activity
HPK19_24125	COG1228	amidohydrolase
HPK19_24135	COG0402	S-adenosylhomocysteine deaminase activity
HPK19_24140	COG0402	S-adenosylhomocysteine deaminase activity
HPK19_24145	COG0402	S-adenosylhomocysteine deaminase activity
HPK19_24155	COG2233	PERMEase
HPK19_24160	COG0322	excinuclease ABC activity
HPK19_24190	COG0697	spore germination
HPK19_24195	COG0531	amino acid
HPK19_24205	COG2814	Major facilitator Superfamily
HPK19_24210	COG1846	Transcriptional regulator
HPK19_24215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPK19_24245	COG1404	Belongs to the peptidase S8 family
HPK19_24265	COG0697	spore germination
HPK19_24280	COG1404	Belongs to the peptidase S8 family
HPK19_24300	COG4977	sequence-specific DNA binding
HPK19_24320	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPK19_24325	COG1228	amidohydrolase
HPK19_24335	COG1404	Belongs to the peptidase S8 family
HPK19_24340	COG0640	Transcriptional regulator
HPK19_24350	COG1846	Transcriptional regulator
HPK19_24365	COG1404	Belongs to the peptidase S8 family
HPK19_24370	COG1404	Belongs to the peptidase S8 family
HPK19_24380	COG1823	symporter activity
HPK19_24390	COG2508	Transcriptional regulator
HPK19_24395	COG2271	Major facilitator Superfamily
HPK19_24400	COG1473	amidohydrolase
HPK19_24405	COG1404	Belongs to the peptidase S8 family
HPK19_24410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPK19_24415	COG0789	Transcriptional regulator
HPK19_24420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPK19_24455	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPK19_24465	COG2002	toxin-antitoxin pair type II binding
HPK19_24475	COG0789	Transcriptional regulator
HPK19_24495	COG1404	Belongs to the peptidase S8 family
HPK19_24515	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPK19_24525	COG0145	ligase activity
HPK19_24600	COG3344	reverse transcriptase
HPK19_24630	COG1404	Belongs to the peptidase S8 family
HPK19_24635	COG1404	Belongs to the peptidase S8 family
HPK19_24640	COG1404	Belongs to the peptidase S8 family
HPK19_24645	COG1404	Belongs to the peptidase S8 family
HPK19_24665	COG3344	reverse transcriptase
HPK19_24690	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HPK19_24715	COG2204	response regulator
HPK19_24720	COG0174	glutamine synthetase
HPK19_24730	COG0531	amino acid
HPK19_24750	COG0395	ABC-type sugar transport system, permease component
HPK19_24760	COG1653	transport
HPK19_24765	COG1940	carbohydrate kinase activity
HPK19_24770	COG4977	sequence-specific DNA binding
HPK19_24770	COG1917	Cupin 2, conserved barrel domain protein
HPK19_24775	COG1482	cell wall glycoprotein biosynthetic process
HPK19_24790	COG4989	oxidoreductase activity
HPK19_24800	COG0531	amino acid
HPK19_24810	COG4873	Protein conserved in bacteria
HPK19_24815	COG2801	Transposase and inactivated derivatives
HPK19_24835	COG4644	lycopene metabolic process
HPK19_24885	COG0791	NLP P60 protein
HPK19_24885	COG0741	lytic transglycosylase activity
HPK19_24945	COG2205	protein histidine kinase activity
HPK19_24950	COG1073	alpha beta
HPK19_24980	COG0768	penicillin binding
HPK19_24990	COG1404	Belongs to the peptidase S8 family
HPK19_24995	COG1404	Belongs to the peptidase S8 family
HPK19_25065	COG4974	Belongs to the 'phage' integrase family
HPK19_25075	COG3773	Cell wall hydrolase
HPK19_25085	COG4974	Belongs to the 'phage' integrase family
HPK19_25170	COG1078	dGTPase activity
HPK19_25215	COG3655	Transcriptional regulator
HPK19_25220	COG1388	LysM domain
HPK19_25220	COG3858	chitin binding
HPK19_25320	COG1404	Belongs to the peptidase S8 family
HPK19_25330	COG0659	secondary active sulfate transmembrane transporter activity
HPK19_25335	COG0288	reversible hydration of carbon dioxide
HPK19_25370	COG0531	amino acid
HPK19_25395	COG2267	carboxylic ester hydrolase activity
HPK19_25425	COG1404	Belongs to the peptidase S8 family
HPK19_25450	COG1404	Belongs to the peptidase S8 family
HPK19_25475	COG1404	Belongs to the peptidase S8 family
HPK19_25495	COG0776	regulation of translation
HPK19_25510	COG3773	Cell wall hydrolase
HPK19_25545	COG2003	Belongs to the UPF0758 family
HPK19_25560	COG2723	6-phospho-beta-galactosidase activity
HPK19_25565	COG2814	Major facilitator Superfamily
HPK19_25570	COG1846	Transcriptional regulator
HPK19_25585	COG0778	Nitroreductase
HPK19_25595	COG0577	efflux transmembrane transporter activity
HPK19_25600	COG1136	(ABC) transporter
HPK19_25630	COG4873	Protein conserved in bacteria
HPK19_25640	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HPK19_25645	COG3119	arylsulfatase activity
HPK19_25650	COG2197	response regulator
HPK19_25655	COG3852	Histidine kinase