locus-tag	class	description
AC20117_00015	COG0483	inositol monophosphate 1-phosphatase activity
AC20117_00020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AC20117_00040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AC20117_00045	COG1321	iron dependent repressor
AC20117_00050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AC20117_00055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AC20117_00060	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AC20117_00080	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AC20117_00085	COG0741	lytic transglycosylase activity
AC20117_00085	COG0739	heme binding
AC20117_00085	COG1196	nuclear chromosome segregation
AC20117_00095	COG2884	Cell division ATP-binding protein ftsE
AC20117_00105	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AC20117_00175	COG0438	transferase activity, transferring glycosyl groups
AC20117_00190	COG0673	inositol 2-dehydrogenase activity
AC20117_00200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AC20117_00205	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AC20117_00230	COG2902	Dehydrogenase
AC20117_00265	COG0653	protein targeting
AC20117_00270	COG3214	Protein conserved in bacteria
AC20117_00275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AC20117_00280	COG1040	competence protein
AC20117_00285	COG5401	PFAM Sporulation and spore germination
AC20117_00290	COG5002	protein histidine kinase activity
AC20117_00290	COG5000	phosphorelay sensor kinase activity
AC20117_00315	COG0714	Associated with various cellular activities
AC20117_00345	COG0482	sulfurtransferase activity
AC20117_00360	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AC20117_00370	COG0484	heat shock protein binding
AC20117_00375	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AC20117_00385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AC20117_00400	COG1842	Phage shock protein A
AC20117_00410	COG1615	UPF0182 protein
AC20117_00415	COG3480	Lon protease (S16) C-terminal proteolytic domain
AC20117_00470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AC20117_00475	COG2011	ABC-type metal ion transport system permease component
AC20117_00480	COG1464	Belongs to the NlpA lipoprotein family
AC20117_00490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AC20117_00495	COG0113	porphobilinogen synthase activity
AC20117_00505	COG0181	hydroxymethylbilane synthase activity
AC20117_00525	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AC20117_00530	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AC20117_00555	COG2154	pterin-4-alpha-carbinolamine dehydratase
AC20117_00560	COG2022	thiamine diphosphate biosynthetic process
AC20117_00575	COG0352	thiamine-phosphate diphosphorylase activity
AC20117_00590	COG0513	Belongs to the DEAD box helicase family
AC20117_00605	COG0613	PHP domain protein
AC20117_00610	COG0006	proline dipeptidase activity
AC20117_00620	COG2239	Acts as a magnesium transporter
AC20117_00635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC20117_00645	COG1595	DNA-templated transcription, initiation
AC20117_00655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC20117_00675	COG1611	Belongs to the LOG family
AC20117_00680	COG1126	abc transporter atp-binding protein
AC20117_00685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AC20117_00690	COG0765	amino acid transport
AC20117_00695	COG0765	amino acid transport
AC20117_00700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_00705	COG2171	N-acyltransferase activity
AC20117_00720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AC20117_00760	COG4172	Belongs to the ABC transporter superfamily
AC20117_00775	COG4166	transmembrane transport
AC20117_00820	COG0012	GTP binding
AC20117_00825	COG1322	Protein conserved in bacteria
AC20117_00830	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AC20117_00840	COG1570	exodeoxyribonuclease VII activity
AC20117_00845	COG1722	exodeoxyribonuclease VII activity
AC20117_00850	COG2326	polyphosphate kinase activity
AC20117_00855	COG0436	Aminotransferase
AC20117_00875	COG0517	IMP dehydrogenase activity
AC20117_00875	COG1125	glycine betaine transport
AC20117_00895	COG5002	protein histidine kinase activity
AC20117_00900	COG0745	RESPONSE REGULATOR receiver
AC20117_00920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AC20117_00925	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AC20117_00945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC20117_00945	COG0519	Catalyzes the synthesis of GMP from XMP
AC20117_00960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC20117_00960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC20117_00965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AC20117_00970	COG0516	GMP reductase activity
AC20117_00990	COG0459	protein refolding
AC20117_00995	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AC20117_01000	COG4607	ABC-type enterochelin transport system periplasmic component
AC20117_01005	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AC20117_01010	COG4605	iron ion homeostasis
AC20117_01015	COG4604	ABC transporter, ATP-binding protein
AC20117_01025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC20117_01030	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AC20117_01070	COG1472	Belongs to the glycosyl hydrolase 3 family
AC20117_01075	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AC20117_01080	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AC20117_01110	COG0802	atpase or kinase
AC20117_01125	COG1486	melibiose metabolic process
AC20117_01130	COG2072	flavoprotein involved in K transport
AC20117_01155	COG2409	Drug exporters of the RND superfamily
AC20117_01175	COG0667	Aldo Keto reductase
AC20117_01225	COG1649	PFAM Uncharacterised BCR, COG1649
AC20117_01245	COG2132	Multicopper oxidase
AC20117_01255	COG0736	holo-[acyl-carrier-protein] synthase activity
AC20117_01265	COG1072	(Pantothenic acid kinase))
AC20117_01275	COG1970	mechanosensitive ion channel activity
AC20117_01285	COG1301	dicarboxylic acid transport
AC20117_01295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC20117_01300	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AC20117_01305	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AC20117_01315	COG0246	Mannitol dehydrogenase
AC20117_01320	COG2213	PTS system mannitol-specific
AC20117_01320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC20117_01350	COG2894	cell division
AC20117_01380	COG0101	tRNA pseudouridine synthase activity
AC20117_01385	COG0203	ribosomal protein L17
AC20117_01390	COG0202	RNA polymerase activity
AC20117_01395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AC20117_01400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AC20117_01405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AC20117_01410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AC20117_01415	COG3191	aminopeptidase activity
AC20117_01430	COG2814	Major facilitator Superfamily
AC20117_01455	COG0563	adenylate kinase activity
AC20117_01465	COG0200	Binds to the 23S rRNA
AC20117_01470	COG1841	ribosomal large subunit assembly
AC20117_01475	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AC20117_01480	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AC20117_01485	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AC20117_01490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AC20117_01495	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AC20117_01500	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AC20117_01505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AC20117_01510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AC20117_01515	COG0255	Belongs to the universal ribosomal protein uL29 family
AC20117_01520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AC20117_01525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AC20117_01530	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AC20117_01535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AC20117_01540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AC20117_01545	COG0089	rRNA binding
AC20117_01550	COG0088	Forms part of the polypeptide exit tunnel
AC20117_01555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AC20117_01560	COG0051	transcription antitermination factor activity, RNA binding
AC20117_01565	COG2723	6-phospho-beta-galactosidase activity
AC20117_01580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC20117_01585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AC20117_01590	COG0049	tRNA binding
AC20117_01595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AC20117_01605	COG2755	lipolytic protein G-D-S-L family
AC20117_01605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AC20117_01610	COG1414	Transcriptional regulator
AC20117_01615	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AC20117_01625	COG0183	Belongs to the thiolase family
AC20117_01630	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AC20117_01645	COG3485	protocatechuate 3,4-dioxygenase
AC20117_01650	COG3485	protocatechuate 3,4-dioxygenase
AC20117_01665	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AC20117_01670	COG0085	RNA polymerase activity
AC20117_01675	COG0183	Belongs to the thiolase family
AC20117_01680	COG0442	prolyl-tRNA aminoacylation
AC20117_01685	COG0222	ribosome binding
AC20117_01690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AC20117_01705	COG0081	regulation of translation
AC20117_01710	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AC20117_01730	COG0436	Aminotransferase
AC20117_01735	COG2197	response regulator
AC20117_01755	COG1983	PspC domain protein
AC20117_01770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AC20117_01775	COG3485	protocatechuate 3,4-dioxygenase
AC20117_01785	COG0745	RESPONSE REGULATOR receiver
AC20117_01790	COG0456	acetyltransferase
AC20117_01795	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AC20117_01805	COG1528	Iron-storage protein
AC20117_01810	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AC20117_01815	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AC20117_01825	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AC20117_01840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AC20117_01850	COG2030	dehydratase
AC20117_01865	COG0693	protein deglycase activity
AC20117_01905	COG1132	(ABC) transporter
AC20117_01910	COG0438	transferase activity, transferring glycosyl groups
AC20117_01935	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC20117_01935	COG1902	pentaerythritol trinitrate reductase activity
AC20117_01940	COG2258	MOSC domain
AC20117_01945	COG1115	amino acid carrier protein
AC20117_01965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC20117_01980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC20117_01995	COG1666	GTP binding
AC20117_02005	COG0501	Belongs to the peptidase M48B family
AC20117_02020	COG2267	carboxylic ester hydrolase activity
AC20117_02030	COG0753	catalase activity
AC20117_02115	COG2894	cell division
AC20117_02120	COG1674	ftsk spoiiie
AC20117_02150	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_02160	COG0733	neurotransmitter:sodium symporter activity
AC20117_02175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_02180	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AC20117_02190	COG2895	sulfate adenylyltransferase (ATP) activity
AC20117_02200	COG0175	sulfate reduction
AC20117_02205	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC20117_02245	COG2226	methyltransferase
AC20117_02250	COG1169	isochorismate synthase
AC20117_02260	COG0765	amino acid transport
AC20117_02275	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AC20117_02285	COG4948	Mandelate Racemase Muconate Lactonizing
AC20117_02315	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC20117_02330	COG1024	Enoyl-CoA hydratase
AC20117_02335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AC20117_02340	COG2151	metal-sulfur cluster biosynthetic enzyme
AC20117_02345	COG3396	Phenylacetate-CoA oxygenase
AC20117_02350	COG3460	Phenylacetate-CoA oxygenase
AC20117_02355	COG3396	Phenylacetate-CoA oxygenase
AC20117_02390	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_02390	COG2030	dehydratase
AC20117_02410	COG2755	lipolytic protein G-D-S-L family
AC20117_02415	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC20117_02420	COG1024	Enoyl-CoA hydratase
AC20117_02440	COG0488	(ABC) transporter
AC20117_02450	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AC20117_02480	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AC20117_02490	COG0785	Cytochrome C biogenesis protein
AC20117_02495	COG3118	belongs to the thioredoxin family
AC20117_02500	COG0406	alpha-ribazole phosphatase activity
AC20117_02505	COG2353	YceI-like domain
AC20117_02515	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AC20117_02525	COG0560	Phosphoserine phosphatase
AC20117_02540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AC20117_02545	COG2971	BadF BadG BcrA BcrD
AC20117_02555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AC20117_02560	COG0640	Transcriptional regulator
AC20117_02565	COG0123	including yeast histone deacetylase and acetoin utilization protein
AC20117_02570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AC20117_02575	COG0569	domain protein
AC20117_02585	COG0248	Ppx GppA phosphatase
AC20117_02590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AC20117_02590	COG1754	DNA topoisomerase type I activity
AC20117_02600	COG2890	protein-(glutamine-N5) methyltransferase activity
AC20117_02620	COG1111	helicase
AC20117_02620	COG1205	dead DEAH box helicase
AC20117_02670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AC20117_02680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC20117_02720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AC20117_02725	COG1408	metallophosphoesterase
AC20117_02745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AC20117_02750	COG0151	Belongs to the GarS family
AC20117_02775	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AC20117_02795	COG0542	response to heat
AC20117_02810	COG2353	YceI-like domain
AC20117_02830	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AC20117_02850	COG2003	Belongs to the UPF0758 family
AC20117_02855	COG0789	Transcriptional regulator
AC20117_02860	COG0484	heat shock protein binding
AC20117_02865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AC20117_02870	COG0443	Heat shock 70 kDa protein
AC20117_02875	COG2409	Drug exporters of the RND superfamily
AC20117_02885	COG2226	methyltransferase
AC20117_02895	COG1280	lysine exporter protein (LysE YggA)
AC20117_02900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC20117_02910	COG1309	transcriptional regulator
AC20117_02920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC20117_02935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC20117_02950	COG4172	Belongs to the ABC transporter superfamily
AC20117_02955	COG4721	ABC-type cobalt transport system, permease component
AC20117_02970	COG2212	antiporter activity
AC20117_02990	COG2111	Na H antiporter
AC20117_02990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC20117_03000	COG0717	Belongs to the dCTP deaminase family
AC20117_03005	COG1876	peptidase activity
AC20117_03010	COG3483	tryptophan 2,3-dioxygenase activity
AC20117_03020	COG0475	glutathione-regulated potassium exporter activity
AC20117_03060	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AC20117_03065	COG0679	Auxin Efflux Carrier
AC20117_03070	COG0433	COG0433 Predicted ATPase
AC20117_03085	COG3336	cytochrome c oxidase
AC20117_03090	COG0776	regulation of translation
AC20117_03095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AC20117_03100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AC20117_03105	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AC20117_03135	COG1742	UPF0060 membrane protein
AC20117_03145	COG1120	ATPase activity
AC20117_03150	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AC20117_03155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AC20117_03160	COG2267	carboxylic ester hydrolase activity
AC20117_03190	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AC20117_03195	COG0435	Glutathione S-transferase
AC20117_03200	COG2031	fatty acid transporter
AC20117_03205	COG2807	transmembrane transport
AC20117_03225	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AC20117_03235	COG0519	Catalyzes the synthesis of GMP from XMP
AC20117_03240	COG0589	response to stress
AC20117_03250	COG0667	Aldo Keto reductase
AC20117_03255	COG0395	ABC-type sugar transport system, permease component
AC20117_03260	COG1175	transmembrane transport
AC20117_03280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AC20117_03295	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_03310	COG0509	glycine decarboxylation via glycine cleavage system
AC20117_03315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AC20117_03320	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC20117_03320	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC20117_03330	COG2807	transmembrane transport
AC20117_03350	COG2814	Major facilitator Superfamily
AC20117_03385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_03390	COG0861	Integral membrane protein TerC family
AC20117_03410	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AC20117_03410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AC20117_03415	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_03430	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AC20117_03430	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AC20117_03435	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AC20117_03440	COG0438	transferase activity, transferring glycosyl groups
AC20117_03450	COG0859	PFAM glycosyl transferase family 9
AC20117_03465	COG1191	sigma factor activity
AC20117_03475	COG2076	Multidrug Resistance protein
AC20117_03480	COG2076	Multidrug Resistance protein
AC20117_03490	COG1295	ribonuclease BN
AC20117_03505	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_03520	COG0598	Magnesium transport protein CorA
AC20117_03545	COG0477	Major facilitator Superfamily
AC20117_03565	COG3634	alkyl hydroperoxide reductase activity
AC20117_03570	COG1254	Belongs to the acylphosphatase family
AC20117_03580	COG1597	lipid kinase activity
AC20117_03585	COG1309	transcriptional regulator
AC20117_03595	COG0589	response to stress
AC20117_03615	COG3290	protein histidine kinase activity
AC20117_03620	COG4565	transcriptional regulatory protein
AC20117_03630	COG0412	Dienelactone hydrolase
AC20117_03635	COG0768	penicillin binding
AC20117_03660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AC20117_03665	COG0765	amino acid transport
AC20117_03670	COG1126	abc transporter atp-binding protein
AC20117_03685	COG3135	benzoate transporter
AC20117_03695	COG0655	NAD(P)H dehydrogenase (quinone) activity
AC20117_03705	COG1793	dna ligase
AC20117_03715	COG0667	Aldo Keto reductase
AC20117_03735	COG0583	DNA-binding transcription factor activity
AC20117_03740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC20117_03745	COG4948	Mandelate Racemase Muconate Lactonizing
AC20117_03750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC20117_03760	COG4608	Belongs to the ABC transporter superfamily
AC20117_03765	COG0444	Belongs to the ABC transporter superfamily
AC20117_03775	COG0601	transmembrane transport
AC20117_03780	COG0747	negative chemotaxis
AC20117_03785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC20117_03790	COG0589	response to stress
AC20117_03795	COG1414	Transcriptional regulator
AC20117_03800	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_03805	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AC20117_03825	COG4989	oxidoreductase activity
AC20117_03845	COG2124	cytochrome p450
AC20117_03855	COG1414	Transcriptional regulator
AC20117_03875	COG1309	transcriptional regulator
AC20117_03880	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC20117_03880	COG1024	Enoyl-CoA hydratase
AC20117_03885	COG1960	acyl-CoA dehydrogenase activity
AC20117_03890	COG0318	PFAM AMP-dependent synthetase and ligase
AC20117_03905	COG0531	amino acid
AC20117_03930	COG4335	DNA alkylation repair
AC20117_03965	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AC20117_04010	COG1116	anion transmembrane transporter activity
AC20117_04015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_04025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC20117_04030	COG1228	amidohydrolase
AC20117_04040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AC20117_04070	COG2217	Heavy metal translocating P-type atpase
AC20117_04075	COG2267	carboxylic ester hydrolase activity
AC20117_04080	COG1414	Transcriptional regulator
AC20117_04090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC20117_04095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AC20117_04100	COG2610	gluconate transmembrane transporter activity
AC20117_04115	COG1940	carbohydrate kinase activity
AC20117_04125	COG0640	Transcriptional regulator
AC20117_04135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AC20117_04145	COG0640	Transcriptional regulator
AC20117_04160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AC20117_04165	COG1072	(Pantothenic acid kinase))
AC20117_04175	COG0747	negative chemotaxis
AC20117_04205	COG1295	ribonuclease BN
AC20117_04230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AC20117_04235	COG0277	FAD linked oxidase domain protein
AC20117_04235	COG0247	lactate metabolic process
AC20117_04245	COG0006	proline dipeptidase activity
AC20117_04255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_04260	COG0477	Major facilitator Superfamily
AC20117_04275	COG0686	Belongs to the AlaDH PNT family
AC20117_04290	COG2801	Transposase and inactivated derivatives
AC20117_04305	COG0438	transferase activity, transferring glycosyl groups
AC20117_04310	COG0463	Glycosyl transferase, family 2
AC20117_04335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_04355	COG2197	response regulator
AC20117_04370	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AC20117_04375	COG4638	Rieske (2fe-2S)
AC20117_04380	COG3135	benzoate transporter
AC20117_04385	COG1869	D-ribose catabolic process
AC20117_04390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC20117_04395	COG1879	ABC-type sugar transport system periplasmic component
AC20117_04400	COG1172	Belongs to the binding-protein-dependent transport system permease family
AC20117_04405	COG1129	ABC transporter
AC20117_04410	COG1609	Transcriptional regulator
AC20117_04420	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_04435	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AC20117_04445	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AC20117_04450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC20117_04455	COG1063	alcohol dehydrogenase
AC20117_04460	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_04465	COG0800	Aldolase
AC20117_04485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC20117_04490	COG1090	epimerase
AC20117_04495	COG1595	DNA-templated transcription, initiation
AC20117_04500	COG0604	alcohol dehydrogenase
AC20117_04505	COG1796	DNA polymerase
AC20117_04505	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AC20117_04540	COG2197	response regulator
AC20117_04545	COG0443	Heat shock 70 kDa protein
AC20117_04570	COG2186	Transcriptional regulator
AC20117_04580	COG1027	Aspartate ammonia-lyase
AC20117_04600	COG0640	Transcriptional regulator
AC20117_04605	COG2814	Major facilitator Superfamily
AC20117_04610	COG0500	methyltransferase
AC20117_04615	COG2851	Citrate transporter
AC20117_04620	COG3290	protein histidine kinase activity
AC20117_04625	COG4565	transcriptional regulatory protein
AC20117_04635	COG3387	PFAM Glycoside hydrolase 15-related
AC20117_04655	COG0667	Aldo Keto reductase
AC20117_04660	COG0673	inositol 2-dehydrogenase activity
AC20117_04670	COG0516	GMP reductase activity
AC20117_04670	COG0517	IMP dehydrogenase activity
AC20117_04675	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AC20117_04680	COG0022	dehydrogenase e1 component
AC20117_04685	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC20117_04700	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AC20117_04710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC20117_04720	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AC20117_04730	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_04750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC20117_04755	COG1937	Protein conserved in bacteria
AC20117_04765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC20117_04775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC20117_04780	COG0477	Major facilitator Superfamily
AC20117_04810	COG1937	Protein conserved in bacteria
AC20117_04820	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_04830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC20117_04840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_04855	COG0583	DNA-binding transcription factor activity
AC20117_04860	COG1522	sequence-specific DNA binding
AC20117_04865	COG1280	lysine exporter protein (LysE YggA)
AC20117_04875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC20117_04890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC20117_04905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC20117_04945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC20117_04965	COG3485	protocatechuate 3,4-dioxygenase
AC20117_04970	COG4638	Rieske (2fe-2S)
AC20117_04990	COG2197	response regulator
AC20117_05000	COG4948	Mandelate Racemase Muconate Lactonizing
AC20117_05005	COG0583	DNA-binding transcription factor activity
AC20117_05020	COG2050	protein possibly involved in aromatic compounds catabolism
AC20117_05025	COG0656	L-ascorbic acid biosynthetic process
AC20117_05055	COG1278	Cold shock
AC20117_05075	COG0154	amidase activity
AC20117_05100	COG1234	tRNA 3'-trailer cleavage
AC20117_05125	COG2267	carboxylic ester hydrolase activity
AC20117_05135	COG1597	lipid kinase activity
AC20117_05155	COG1690	Belongs to the RtcB family
AC20117_05195	COG2211	Major facilitator Superfamily
AC20117_05225	COG0656	L-ascorbic acid biosynthetic process
AC20117_05240	COG1960	acyl-CoA dehydrogenase activity
AC20117_05250	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_05260	COG1116	anion transmembrane transporter activity
AC20117_05265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_05270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_05275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC20117_05300	COG2197	response regulator
AC20117_05305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC20117_05320	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC20117_05325	COG0022	dehydrogenase e1 component
AC20117_05335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC20117_05340	COG1950	PFAM Membrane protein of
AC20117_05345	COG2223	nitrite transmembrane transporter activity
AC20117_05350	COG0243	molybdopterin cofactor binding
AC20117_05355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC20117_05370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AC20117_05390	COG1607	acyl-coa hydrolase
AC20117_05400	COG0436	Aminotransferase
AC20117_05415	COG1725	Transcriptional regulator
AC20117_05420	COG0589	response to stress
AC20117_05440	COG0583	DNA-binding transcription factor activity
AC20117_05445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC20117_05465	COG3591	Belongs to the peptidase S1B family
AC20117_05465	COG1864	DNA RNA non-specific endonuclease
AC20117_05485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC20117_05520	COG0477	Major facilitator Superfamily
AC20117_05525	COG1937	Protein conserved in bacteria
AC20117_05530	COG2217	Heavy metal translocating P-type atpase
AC20117_05550	COG2271	Major facilitator Superfamily
AC20117_05555	COG0697	spore germination
AC20117_05590	COG0534	Mate efflux family protein
AC20117_05600	COG1131	(ABC) transporter
AC20117_05620	COG2890	protein-(glutamine-N5) methyltransferase activity
AC20117_05640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AC20117_05650	COG0833	amino acid
AC20117_05680	COG1982	Orn Lys Arg decarboxylase major
AC20117_05685	COG3177	Filamentation induced by cAMP protein fic
AC20117_05700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC20117_05710	COG2814	Major facilitator Superfamily
AC20117_05725	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AC20117_05725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC20117_05740	COG0531	amino acid
AC20117_05765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC20117_05770	COG1929	Belongs to the glycerate kinase type-1 family
AC20117_05775	COG3960	tartronate-semialdehyde synthase activity
AC20117_05780	COG2084	Dehydrogenase
AC20117_05785	COG3622	Belongs to the hyi family
AC20117_05795	COG3655	Transcriptional regulator
AC20117_05800	COG3257	ureidoglycine aminohydrolase activity
AC20117_05820	COG1414	Transcriptional regulator
AC20117_05825	COG0590	tRNA wobble adenosine to inosine editing
AC20117_05830	COG2252	PERMEase
AC20117_05835	COG3608	succinylglutamate desuccinylase aspartoacylase
AC20117_05835	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AC20117_05845	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC20117_05845	COG2080	2 iron, 2 sulfur cluster binding
AC20117_05855	COG0583	DNA-binding transcription factor activity
AC20117_05860	COG1053	succinate dehydrogenase
AC20117_05895	COG0405	Gamma-glutamyltransferase
AC20117_05935	COG2233	PERMEase
AC20117_05960	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AC20117_05970	COG0469	pyruvate kinase activity
AC20117_05985	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AC20117_06020	COG3583	domain protein
AC20117_06025	COG1045	serine acetyltransferase
AC20117_06040	COG1253	flavin adenine dinucleotide binding
AC20117_06070	COG2188	Transcriptional regulator
AC20117_06085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC20117_06095	COG2814	Major facilitator Superfamily
AC20117_06100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC20117_06130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC20117_06165	COG1280	lysine exporter protein (LysE YggA)
AC20117_06170	COG2409	Drug exporters of the RND superfamily
AC20117_06175	COG2084	Dehydrogenase
AC20117_06220	COG0384	phenazine biosynthesis protein PhzF
AC20117_06230	COG0359	binds to the 23S rRNA
AC20117_06235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AC20117_06245	COG0360	Binds together with S18 to 16S ribosomal RNA
AC20117_06255	COG2197	response regulator
AC20117_06260	COG4585	Histidine kinase
AC20117_06275	COG0738	Major facilitator superfamily
AC20117_06280	COG0488	(ABC) transporter
AC20117_06290	COG2197	response regulator
AC20117_06295	COG0179	Fumarylacetoacetate (FAA) hydrolase
AC20117_06310	COG2197	response regulator
AC20117_06325	COG1136	(ABC) transporter
AC20117_06325	COG0577	efflux transmembrane transporter activity
AC20117_06330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AC20117_06345	COG1083	cytidylyl-transferase
AC20117_06350	COG2089	acid synthase
AC20117_06355	COG0463	Glycosyl transferase, family 2
AC20117_06425	COG1063	alcohol dehydrogenase
AC20117_06455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AC20117_06470	COG0601	transmembrane transport
AC20117_06475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AC20117_06495	COG0477	Major facilitator Superfamily
AC20117_06500	COG1234	tRNA 3'-trailer cleavage
AC20117_06505	COG0583	DNA-binding transcription factor activity
AC20117_06515	COG4770	biotin carboxylase activity
AC20117_06520	COG1984	allophanate hydrolase subunit 2
AC20117_06525	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AC20117_06530	COG1914	H( )-stimulated, divalent metal cation uptake system
AC20117_06535	COG4336	lyase activity
AC20117_06575	COG0583	DNA-binding transcription factor activity
AC20117_06585	COG1063	alcohol dehydrogenase
AC20117_06595	COG0477	Major facilitator Superfamily
AC20117_06620	COG1053	succinate dehydrogenase
AC20117_06625	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AC20117_06630	COG4974	Belongs to the 'phage' integrase family
AC20117_06645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AC20117_06670	COG0765	amino acid transport
AC20117_06685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AC20117_06690	COG0277	FAD linked oxidase domain protein
AC20117_06690	COG0247	lactate metabolic process
AC20117_06720	COG0402	S-adenosylhomocysteine deaminase activity
AC20117_06765	COG1335	isochorismatase
AC20117_06790	COG4608	Belongs to the ABC transporter superfamily
AC20117_06795	COG0444	Belongs to the ABC transporter superfamily
AC20117_06800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AC20117_06805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AC20117_06815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC20117_06860	COG0758	DNA mediated transformation
AC20117_06870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC20117_06875	COG1024	Enoyl-CoA hydratase
AC20117_06880	COG0318	PFAM AMP-dependent synthetase and ligase
AC20117_06895	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_06900	COG1960	acyl-CoA dehydrogenase activity
AC20117_06905	COG0183	Belongs to the thiolase family
AC20117_06910	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC20117_06930	COG0559	Belongs to the binding-protein-dependent transport system permease family
AC20117_06940	COG0410	ABC transporter
AC20117_06945	COG2050	protein possibly involved in aromatic compounds catabolism
AC20117_06950	COG1846	Transcriptional regulator
AC20117_07005	COG3328	transposase activity
AC20117_07050	COG2814	Major facilitator Superfamily
AC20117_07055	COG0640	Transcriptional regulator
AC20117_07070	COG0803	Belongs to the bacterial solute-binding protein 9 family
AC20117_07100	COG0659	secondary active sulfate transmembrane transporter activity
AC20117_07175	COG2801	Transposase and inactivated derivatives
AC20117_07200	COG2132	Multicopper oxidase
AC20117_07215	COG0583	DNA-binding transcription factor activity
AC20117_07240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_07255	COG4638	Rieske (2fe-2S)
AC20117_07270	COG0588	phosphoglycerate mutase activity
AC20117_07275	COG0617	tRNA 3'-terminal CCA addition
AC20117_07300	COG3118	belongs to the thioredoxin family
AC20117_07305	COG0860	N-Acetylmuramoyl-L-alanine amidase
AC20117_07305	COG3409	Peptidoglycan-binding domain 1 protein
AC20117_07315	COG1475	DNA binding
AC20117_07320	COG1192	Involved in chromosome partitioning
AC20117_07325	COG0357	Ribosomal RNA small subunit methyltransferase G
AC20117_07335	COG0706	membrane insertase activity
AC20117_07340	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AC20117_07345	COG0594	ribonuclease P activity
AC20117_07350	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AC20117_07355	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AC20117_07360	COG0592	DNA-directed DNA polymerase activity
AC20117_07365	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AC20117_07370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AC20117_07375	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AC20117_07380	COG0187	DNA topoisomerase II activity
AC20117_07385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AC20117_07390	COG3266	domain, Protein
AC20117_07410	COG1215	transferase activity, transferring glycosyl groups
AC20117_07425	COG0705	Rhomboid family
AC20117_07425	COG0457	Tetratricopeptide repeat
AC20117_07430	COG0281	malic enzyme
AC20117_07440	COG3764	Sortase (surface protein transpeptidase)
AC20117_07450	COG0515	serine threonine protein kinase
AC20117_07450	COG2815	serine threonine protein kinase
AC20117_07455	COG0515	serine threonine protein kinase
AC20117_07475	COG1716	ATPase activity
AC20117_07480	COG1716	ATPase activity
AC20117_07490	COG0346	lactoylglutathione lyase activity
AC20117_07505	COG0483	inositol monophosphate 1-phosphatase activity
AC20117_07510	COG1024	Enoyl-CoA hydratase
AC20117_07515	COG2353	YceI-like domain
AC20117_07555	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AC20117_07565	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AC20117_07570	COG1609	Transcriptional regulator
AC20117_07585	COG0561	phosphatase activity
AC20117_07590	COG0584	glycerophosphoryl diester phosphodiesterase
AC20117_07595	COG1929	Belongs to the glycerate kinase type-1 family
AC20117_07615	COG3360	Dodecin
AC20117_07620	COG2233	PERMEase
AC20117_07625	COG0778	Nitroreductase
AC20117_07630	COG0033	Phosphoglucomutase
AC20117_07645	COG0798	PFAM Bile acid sodium symporter
AC20117_07660	COG2249	NAD(P)H dehydrogenase (quinone) activity
AC20117_07665	COG1733	regulation of RNA biosynthetic process
AC20117_07670	COG3104	oligopeptide transport
AC20117_07680	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AC20117_07685	COG3340	Belongs to the peptidase S51 family
AC20117_07690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC20117_07710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AC20117_07715	COG0561	phosphatase activity
AC20117_07725	COG3654	unkown
AC20117_07745	COG2027	D-alanyl-D-alanine carboxypeptidase
AC20117_07755	COG0037	tRNA processing
AC20117_07765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AC20117_07770	COG0302	gtp cyclohydrolase
AC20117_07780	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AC20117_07785	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AC20117_07810	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AC20117_07815	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AC20117_07825	COG0542	response to heat
AC20117_07835	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AC20117_07845	COG3237	CsbD-like
AC20117_07865	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AC20117_07895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AC20117_07920	COG0456	acetyltransferase
AC20117_07925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AC20117_07930	COG1917	Cupin 2, conserved barrel domain protein
AC20117_07935	COG5285	phytanoyl-CoA dioxygenase
AC20117_07945	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_07950	COG0831	urea catabolic process
AC20117_07955	COG0832	Belongs to the urease beta subunit family
AC20117_07960	COG0804	urea catabolic process
AC20117_07965	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AC20117_07970	COG0830	nickel cation binding
AC20117_07975	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AC20117_07980	COG0829	nickel cation binding
AC20117_07985	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AC20117_07990	COG0531	amino acid
AC20117_08015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC20117_08020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC20117_08020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AC20117_08020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AC20117_08025	COG1105	Belongs to the carbohydrate kinase PfkB family
AC20117_08030	COG1349	DNA-binding transcription factor activity
AC20117_08055	COG2733	membrane
AC20117_08060	COG0584	glycerophosphoryl diester phosphodiesterase
AC20117_08085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AC20117_08105	COG2252	PERMEase
AC20117_08110	COG2372	response to copper ion
AC20117_08185	COG1653	transport
AC20117_08190	COG1175	transmembrane transport
AC20117_08195	COG0395	ABC-type sugar transport system, permease component
AC20117_08210	COG4941	Belongs to the sigma-70 factor family
AC20117_08225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AC20117_08255	COG1172	Belongs to the binding-protein-dependent transport system permease family
AC20117_08260	COG1129	ABC transporter
AC20117_08265	COG1940	carbohydrate kinase activity
AC20117_08270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AC20117_08315	COG1435	thymidine kinase activity
AC20117_08325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AC20117_08335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC20117_08355	COG1832	CoA-binding protein
AC20117_08375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC20117_08380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_08390	COG1116	anion transmembrane transporter activity
AC20117_08400	COG1832	CoA-binding protein
AC20117_08410	COG0477	Major facilitator Superfamily
AC20117_08435	COG2315	Protein conserved in bacteria
AC20117_08460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AC20117_08465	COG0047	phosphoribosylformylglycinamidine synthase activity
AC20117_08470	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AC20117_08490	COG1846	Transcriptional regulator
AC20117_08510	COG1126	abc transporter atp-binding protein
AC20117_08515	COG0765	amino acid transport
AC20117_08520	COG0765	amino acid transport
AC20117_08535	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AC20117_08610	COG2814	Major facilitator Superfamily
AC20117_08660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC20117_08665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AC20117_08670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AC20117_08685	COG2855	membrane
AC20117_08695	COG3634	alkyl hydroperoxide reductase activity
AC20117_08705	COG4106	trans-aconitate 2-methyltransferase activity
AC20117_08725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC20117_08730	COG0251	oxidation-reduction process
AC20117_08765	COG1414	Transcriptional regulator
AC20117_08775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC20117_08795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_08800	COG0523	cobalamin synthesis protein
AC20117_08820	COG3949	Membrane
AC20117_08870	COG0252	asparaginase activity
AC20117_08875	COG2807	transmembrane transport
AC20117_08880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_08890	COG1953	Uracil, thiamine, allantoin
AC20117_08895	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC20117_08910	COG1609	Transcriptional regulator
AC20117_08925	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AC20117_08935	COG1473	amidohydrolase
AC20117_08985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_09015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC20117_09030	COG1174	glycine betaine transport
AC20117_09040	COG1174	glycine betaine transport
AC20117_09045	COG1732	Glycine betaine
AC20117_09050	COG3119	arylsulfatase activity
AC20117_09055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AC20117_09085	COG0640	Transcriptional regulator
AC20117_09095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC20117_09110	COG0477	Major facilitator Superfamily
AC20117_09145	COG2910	NAD(P)H-binding
AC20117_09150	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AC20117_09160	COG2807	transmembrane transport
AC20117_09180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC20117_09190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AC20117_09200	COG1129	ABC transporter
AC20117_09205	COG1172	Belongs to the binding-protein-dependent transport system permease family
AC20117_09225	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AC20117_09235	COG1414	Transcriptional regulator
AC20117_09250	COG1609	Transcriptional regulator
AC20117_09260	COG2814	Major facilitator Superfamily
AC20117_09270	COG0698	ribose 5-phosphate isomerase
AC20117_09275	COG2376	Dihydroxyacetone kinase
AC20117_09280	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_09285	COG1082	Xylose isomerase domain protein TIM barrel
AC20117_09295	COG3959	Transketolase, thiamine diphosphate binding domain
AC20117_09300	COG3958	Transketolase
AC20117_09325	COG1414	Transcriptional regulator
AC20117_09355	COG2124	cytochrome p450
AC20117_09360	COG0028	Belongs to the TPP enzyme family
AC20117_09385	COG4176	ABC-type proline glycine betaine transport system permease component
AC20117_09395	COG1116	anion transmembrane transporter activity
AC20117_09395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC20117_09405	COG0667	Aldo Keto reductase
AC20117_09450	COG2271	Major facilitator Superfamily
AC20117_09465	COG1929	Belongs to the glycerate kinase type-1 family
AC20117_09470	COG3246	L-lysine catabolic process to acetate
AC20117_09485	COG1609	Transcriptional regulator
AC20117_09500	COG2135	peptidase activity
AC20117_09510	COG3634	alkyl hydroperoxide reductase activity
AC20117_09530	COG1063	alcohol dehydrogenase
AC20117_09535	COG2860	membrane
AC20117_09540	COG1473	amidohydrolase
AC20117_09550	COG0366	Alpha amylase catalytic
AC20117_09560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AC20117_09565	COG1113	amino acid transport
AC20117_09585	COG2130	NADP-dependent
AC20117_09595	COG0277	FAD linked oxidase domain protein
AC20117_09615	COG1595	DNA-templated transcription, initiation
AC20117_09620	COG1252	NADH dehydrogenase
AC20117_09625	COG0583	DNA-binding transcription factor activity
AC20117_09635	COG0477	Major facilitator Superfamily
AC20117_09645	COG1414	Transcriptional regulator
AC20117_09655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AC20117_09660	COG1024	Enoyl-CoA hydratase
AC20117_09670	COG1942	4-Oxalocrotonate Tautomerase
AC20117_09675	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_09680	COG0596	Alpha beta hydrolase
AC20117_09695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_09700	COG1802	Transcriptional regulator
AC20117_09705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC20117_09710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC20117_09715	COG0542	response to heat
AC20117_09735	COG0596	Alpha beta hydrolase
AC20117_09745	COG2132	Multicopper oxidase
AC20117_09770	COG1793	dna ligase
AC20117_09775	COG2197	response regulator
AC20117_09780	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC20117_09790	COG0589	response to stress
AC20117_09810	COG0583	DNA-binding transcription factor activity
AC20117_09820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AC20117_09835	COG0351	phosphomethylpyrimidine kinase
AC20117_09865	COG0343	queuine tRNA-ribosyltransferase activity
AC20117_09895	COG3842	ATPase activity
AC20117_09920	COG1960	acyl-CoA dehydrogenase activity
AC20117_09935	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AC20117_09945	COG1414	Transcriptional regulator
AC20117_09955	COG0574	Belongs to the PEP-utilizing enzyme family
AC20117_09955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC20117_09960	COG0574	Belongs to the PEP-utilizing enzyme family
AC20117_09960	COG3848	Pyruvate phosphate dikinase
AC20117_09965	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_09990	COG0477	Major facilitator Superfamily
AC20117_09995	COG1234	tRNA 3'-trailer cleavage
AC20117_10010	COG4115	mRNA cleavage
AC20117_10045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC20117_10050	COG3546	catalase activity
AC20117_10055	COG0564	pseudouridine synthase activity
AC20117_10070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AC20117_10075	COG1201	RNA secondary structure unwinding
AC20117_10095	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AC20117_10140	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AC20117_10150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC20117_10155	COG2062	phosphohistidine phosphatase, SixA
AC20117_10175	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AC20117_10180	COG0574	Belongs to the PEP-utilizing enzyme family
AC20117_10180	COG3848	Pyruvate phosphate dikinase
AC20117_10190	COG1959	2 iron, 2 sulfur cluster binding
AC20117_10200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC20117_10215	COG1505	serine-type exopeptidase activity
AC20117_10245	COG1966	Carbon starvation protein
AC20117_10280	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AC20117_10285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AC20117_10305	COG0588	phosphoglycerate mutase activity
AC20117_10310	COG0704	Plays a role in the regulation of phosphate uptake
AC20117_10315	COG5002	protein histidine kinase activity
AC20117_10330	COG2801	Transposase and inactivated derivatives
AC20117_10345	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AC20117_10350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AC20117_10355	COG0215	cysteine-tRNA ligase activity
AC20117_10360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC20117_10385	COG1295	ribonuclease BN
AC20117_10410	COG0366	Alpha amylase catalytic
AC20117_10415	COG0366	Alpha amylase catalytic
AC20117_10420	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC20117_10490	COG0277	FAD linked oxidase domain protein
AC20117_10495	COG2264	protein methyltransferase activity
AC20117_10505	COG3842	ATPase activity
AC20117_10545	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AC20117_10590	COG0582	viral genome integration into host DNA
AC20117_10620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC20117_10625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_10630	COG0477	Major facilitator Superfamily
AC20117_10635	COG1609	Transcriptional regulator
AC20117_10640	COG0673	inositol 2-dehydrogenase activity
AC20117_10650	COG1053	succinate dehydrogenase
AC20117_10655	COG1414	Transcriptional regulator
AC20117_10665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AC20117_10670	COG0477	Major facilitator Superfamily
AC20117_10700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AC20117_10720	COG2314	TM2 domain
AC20117_10725	COG0459	protein refolding
AC20117_10745	COG2205	protein histidine kinase activity
AC20117_10750	COG0745	RESPONSE REGULATOR receiver
AC20117_10760	COG1061	Type III restriction enzyme res subunit
AC20117_10775	COG1278	Cold shock
AC20117_10785	COG2814	Major facilitator Superfamily
AC20117_10800	COG0739	heme binding
AC20117_10835	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AC20117_10855	COG1132	(ABC) transporter
AC20117_10880	COG0668	transmembrane transport
AC20117_10885	COG0045	succinate-CoA ligase (ADP-forming) activity
AC20117_10895	COG1063	alcohol dehydrogenase
AC20117_10900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AC20117_10915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC20117_10925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC20117_10940	COG1414	Transcriptional regulator
AC20117_10975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AC20117_11000	COG1760	l-serine dehydratase
AC20117_11045	COG3172	ATPase kinase involved in NAD metabolism
AC20117_11045	COG1056	cytidyltransferase-related domain
AC20117_11055	COG0028	Belongs to the TPP enzyme family
AC20117_11065	COG2186	Transcriptional regulator
AC20117_11070	COG1653	transport
AC20117_11080	COG0395	ABC-type sugar transport system, permease component
AC20117_11085	COG4948	Mandelate Racemase Muconate Lactonizing
AC20117_11090	COG0800	Aldolase
AC20117_11095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC20117_11105	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AC20117_11110	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AC20117_11115	COG1063	alcohol dehydrogenase
AC20117_11125	COG0739	heme binding
AC20117_11135	COG0431	NADPH-dependent FMN reductase
AC20117_11165	COG0477	Major facilitator Superfamily
AC20117_11185	COG3012	SEC-C Motif Domain Protein
AC20117_11190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AC20117_11215	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AC20117_11220	COG0076	glutamate decarboxylase activity
AC20117_11235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC20117_11285	COG1329	Transcriptional regulator
AC20117_11290	COG1309	transcriptional regulator
AC20117_11305	COG1278	Cold shock
AC20117_11365	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_11370	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AC20117_11405	COG0671	phosphoesterase, PA-phosphatase related
AC20117_11435	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AC20117_11440	COG0831	urea catabolic process
AC20117_11445	COG0832	Belongs to the urease beta subunit family
AC20117_11450	COG0804	urea catabolic process
AC20117_11455	COG0830	nickel cation binding
AC20117_11460	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AC20117_11465	COG0829	nickel cation binding
AC20117_11480	COG2323	membrane
AC20117_11490	COG2197	response regulator
AC20117_11495	COG4585	Histidine kinase
AC20117_11505	COG0252	asparaginase activity
AC20117_11525	COG0484	heat shock protein binding
AC20117_11535	COG0789	Transcriptional regulator
AC20117_11575	COG2814	Major facilitator Superfamily
AC20117_11580	COG1388	LysM domain
AC20117_11580	COG0791	NLP P60 protein
AC20117_11590	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AC20117_11600	COG0156	8-amino-7-oxononanoate synthase activity
AC20117_11605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AC20117_11610	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AC20117_11615	COG2188	Transcriptional regulator
AC20117_11620	COG1620	l-lactate permease
AC20117_11630	COG2066	Belongs to the glutaminase family
AC20117_11630	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AC20117_11635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC20117_11650	COG0697	spore germination
AC20117_11655	COG1090	epimerase
AC20117_11660	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AC20117_11690	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AC20117_11695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AC20117_11700	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AC20117_11705	COG1120	ATPase activity
AC20117_11715	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AC20117_11715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC20117_11740	COG1902	pentaerythritol trinitrate reductase activity
AC20117_11775	COG0477	Major facilitator Superfamily
AC20117_11805	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AC20117_11810	COG0702	epimerase
AC20117_11820	COG0783	Belongs to the Dps family
AC20117_11840	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AC20117_11840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC20117_11850	COG2329	Antibiotic biosynthesis monooxygenase
AC20117_11860	COG3639	organic phosphonate transmembrane transporter activity
AC20117_11865	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AC20117_11875	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AC20117_11875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC20117_11885	COG0647	UMP catabolic process
AC20117_11890	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AC20117_11900	COG0789	Transcriptional regulator
AC20117_11905	COG1064	alcohol dehydrogenase
AC20117_11960	COG0179	Fumarylacetoacetate (FAA) hydrolase
AC20117_11965	COG1802	Transcriptional regulator
AC20117_11970	COG1953	Uracil, thiamine, allantoin
AC20117_11980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC20117_11990	COG0477	Major facilitator Superfamily
AC20117_12005	COG1802	Transcriptional regulator
AC20117_12025	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC20117_12030	COG2072	flavoprotein involved in K transport
AC20117_12045	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_12060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC20117_12095	COG0477	Major facilitator Superfamily
AC20117_12100	COG0028	Belongs to the TPP enzyme family
AC20117_12110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_12120	COG2186	Transcriptional regulator
AC20117_12125	COG0747	negative chemotaxis
AC20117_12155	COG2186	Transcriptional regulator
AC20117_12160	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_12165	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_12170	COG1802	Transcriptional regulator
AC20117_12175	COG0473	3-isopropylmalate dehydrogenase activity
AC20117_12180	COG0583	DNA-binding transcription factor activity
AC20117_12210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC20117_12215	COG2364	Membrane
AC20117_12235	COG1960	acyl-CoA dehydrogenase activity
AC20117_12240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AC20117_12250	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_12260	COG0579	oxidoreductase
AC20117_12290	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_12300	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC20117_12305	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_12310	COG1960	acyl-CoA dehydrogenase activity
AC20117_12330	COG0531	amino acid
AC20117_12340	COG0833	amino acid
AC20117_12345	COG2124	cytochrome p450
AC20117_12370	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AC20117_12375	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AC20117_12390	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_12410	COG2508	Transcriptional regulator
AC20117_12450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_12460	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AC20117_12465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AC20117_12480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC20117_12550	COG1917	Cupin 2, conserved barrel domain protein
AC20117_12550	COG4977	sequence-specific DNA binding
AC20117_12555	COG0583	DNA-binding transcription factor activity
AC20117_12560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC20117_12570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_12580	COG1234	tRNA 3'-trailer cleavage
AC20117_12585	COG1454	alcohol dehydrogenase
AC20117_12590	COG1802	Transcriptional regulator
AC20117_12595	COG1053	succinate dehydrogenase
AC20117_12615	COG2205	protein histidine kinase activity
AC20117_12620	COG0745	RESPONSE REGULATOR receiver
AC20117_12625	COG0574	Belongs to the PEP-utilizing enzyme family
AC20117_12625	COG3848	Pyruvate phosphate dikinase
AC20117_12630	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AC20117_12630	COG0517	IMP dehydrogenase activity
AC20117_12655	COG2267	carboxylic ester hydrolase activity
AC20117_12720	COG1595	DNA-templated transcription, initiation
AC20117_12730	COG0028	Belongs to the TPP enzyme family
AC20117_12735	COG1802	Transcriptional regulator
AC20117_12750	COG3608	succinylglutamate desuccinylase aspartoacylase
AC20117_12760	COG0765	amino acid transport
AC20117_12790	COG1473	amidohydrolase
AC20117_12820	COG0640	Transcriptional regulator
AC20117_12835	COG1595	DNA-templated transcription, initiation
AC20117_12875	COG0488	(ABC) transporter
AC20117_12910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AC20117_12920	COG2186	Transcriptional regulator
AC20117_12925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC20117_12950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC20117_12965	COG3485	protocatechuate 3,4-dioxygenase
AC20117_12985	COG0028	Belongs to the TPP enzyme family
AC20117_13020	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AC20117_13020	COG2066	Belongs to the glutaminase family
AC20117_13080	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AC20117_13100	COG5479	isomerase activity
AC20117_13100	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AC20117_13130	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AC20117_13150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AC20117_13160	COG2957	Belongs to the agmatine deiminase family
AC20117_13165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC20117_13175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC20117_13205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AC20117_13220	COG3842	ATPase activity
AC20117_13225	COG1176	ABC-type spermidine putrescine transport system, permease component I
AC20117_13230	COG1177	transmembrane transport
AC20117_13255	COG5416	Lipopolysaccharide assembly protein A domain
AC20117_13265	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AC20117_13275	COG3173	Aminoglycoside phosphotransferase
AC20117_13310	COG0406	alpha-ribazole phosphatase activity
AC20117_13325	COG0753	catalase activity
AC20117_13340	COG0589	response to stress
AC20117_13365	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AC20117_13395	COG0747	negative chemotaxis
AC20117_13400	COG3971	2-oxopent-4-enoate hydratase activity
AC20117_13410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AC20117_13410	COG0438	transferase activity, transferring glycosyl groups
AC20117_13460	COG0477	Major facilitator Superfamily
AC20117_13465	COG0138	bifunctional purine biosynthesis protein purh
AC20117_13475	COG2838	Isocitrate dehydrogenase
AC20117_13515	COG0385	Bile acid
AC20117_13520	COG0673	inositol 2-dehydrogenase activity
AC20117_13530	COG1136	(ABC) transporter
AC20117_13535	COG0577	efflux transmembrane transporter activity
AC20117_13535	COG1136	(ABC) transporter
AC20117_13550	COG1175	transmembrane transport
AC20117_13555	COG1653	transport
AC20117_13570	COG2226	methyltransferase
AC20117_13580	COG0492	ferredoxin-NADP+ reductase activity
AC20117_13585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AC20117_13590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AC20117_13595	COG4585	Histidine kinase
AC20117_13600	COG2197	response regulator
AC20117_13610	COG0477	Major facilitator Superfamily
AC20117_13635	COG0583	DNA-binding transcription factor activity
AC20117_13640	COG1131	(ABC) transporter
AC20117_13670	COG0180	Tryptophanyl-tRNA synthetase
AC20117_13690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AC20117_13705	COG2009	succinate dehydrogenase
AC20117_13715	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AC20117_13715	COG1473	amidohydrolase
AC20117_13720	COG1744	ABC transporter substrate-binding protein PnrA-like
AC20117_13750	COG0586	Pfam SNARE associated Golgi protein
AC20117_13755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AC20117_13760	COG3956	TIGRFAM MazG family protein
AC20117_13765	COG0148	phosphopyruvate hydratase activity
AC20117_13790	COG1252	NADH dehydrogenase
AC20117_13830	COG0559	Belongs to the binding-protein-dependent transport system permease family
AC20117_13835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AC20117_13845	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AC20117_13855	COG2017	converts alpha-aldose to the beta-anomer
AC20117_13865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AC20117_13875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC20117_13885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AC20117_13895	COG1331	Highly conserved protein containing a thioredoxin domain
AC20117_13905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AC20117_13910	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AC20117_13925	COG2197	response regulator
AC20117_13960	COG0114	fumarate hydratase activity
AC20117_13965	COG0288	reversible hydration of carbon dioxide
AC20117_13975	COG1494	fructose-1,6-bisphosphatase
AC20117_13985	COG1482	cell wall glycoprotein biosynthetic process
AC20117_14000	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AC20117_14050	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AC20117_14055	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AC20117_14075	COG1022	Amp-dependent synthetase and ligase
AC20117_14105	COG0714	Associated with various cellular activities
AC20117_14110	COG0084	hydrolase, TatD family'
AC20117_14115	COG3583	domain protein
AC20117_14120	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AC20117_14125	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AC20117_14130	COG0488	(ABC) transporter
AC20117_14140	COG2226	methyltransferase
AC20117_14165	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AC20117_14195	COG0659	secondary active sulfate transmembrane transporter activity
AC20117_14200	COG0542	response to heat
AC20117_14215	COG4566	intracellular signal transduction
AC20117_14225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC20117_14230	COG0726	polysaccharide deacetylase
AC20117_14270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC20117_14295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AC20117_14300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AC20117_14335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_14340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AC20117_14345	COG0251	oxidation-reduction process
AC20117_14350	COG0477	Major facilitator Superfamily
AC20117_14380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_14385	COG0569	domain protein
AC20117_14390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AC20117_14415	COG3559	Exporter of polyketide antibiotics
AC20117_14420	COG1131	(ABC) transporter
AC20117_14430	COG2197	response regulator
AC20117_14435	COG0596	Alpha beta hydrolase
AC20117_14505	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_14515	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AC20117_14535	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AC20117_14555	COG1953	Uracil, thiamine, allantoin
AC20117_14560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_14615	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_14635	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AC20117_14660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC20117_14670	COG0489	protein tyrosine kinase activity
AC20117_14670	COG3206	protein involved in exopolysaccharide biosynthesis
AC20117_14675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AC20117_14680	COG0193	aminoacyl-tRNA hydrolase activity
AC20117_14690	COG0822	iron-sulfur transferase activity
AC20117_14695	COG2801	Transposase and inactivated derivatives
AC20117_14720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC20117_14725	COG0438	transferase activity, transferring glycosyl groups
AC20117_14765	COG2801	Transposase and inactivated derivatives
AC20117_14795	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AC20117_14800	COG1088	dTDP-glucose 4,6-dehydratase activity
AC20117_14830	COG2271	Major facilitator Superfamily
AC20117_14845	COG5002	protein histidine kinase activity
AC20117_14860	COG1846	Transcriptional regulator
AC20117_14865	COG0515	serine threonine protein kinase
AC20117_14865	COG2815	serine threonine protein kinase
AC20117_14885	COG2354	Protein conserved in bacteria
AC20117_14895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AC20117_14900	COG4214	carbohydrate transport
AC20117_14910	COG4213	ABC transporter substrate-binding protein
AC20117_14915	COG3328	transposase activity
AC20117_14920	COG1063	alcohol dehydrogenase
AC20117_14950	COG3835	regulator
AC20117_14960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AC20117_14995	COG1126	abc transporter atp-binding protein
AC20117_15000	COG0765	amino acid transport
AC20117_15015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC20117_15035	COG0402	S-adenosylhomocysteine deaminase activity
AC20117_15040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC20117_15045	COG1126	abc transporter atp-binding protein
AC20117_15050	COG0765	amino acid transport
AC20117_15060	COG1522	sequence-specific DNA binding
AC20117_15100	COG0583	DNA-binding transcription factor activity
AC20117_15105	COG2076	Multidrug Resistance protein
AC20117_15115	COG2124	cytochrome p450
AC20117_15135	COG5002	protein histidine kinase activity
AC20117_15160	COG0179	Fumarylacetoacetate (FAA) hydrolase
AC20117_15175	COG4948	Mandelate Racemase Muconate Lactonizing
AC20117_15180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AC20117_15190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC20117_15205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC20117_15210	COG1126	abc transporter atp-binding protein
AC20117_15220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_15225	COG0583	DNA-binding transcription factor activity
AC20117_15230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC20117_15235	COG2368	4-hydroxyphenylacetate
AC20117_15255	COG1027	Aspartate ammonia-lyase
AC20117_15260	COG1309	transcriptional regulator
AC20117_15265	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_15270	COG0531	amino acid
AC20117_15305	COG2207	Transcriptional regulator
AC20117_15325	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AC20117_15325	COG3266	domain, Protein
AC20117_15325	COG4932	domain protein
AC20117_15335	COG1404	Belongs to the peptidase S8 family
AC20117_15345	COG5634	Uncharacterized conserved protein (DUF2278)
AC20117_15360	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AC20117_15370	COG0515	serine threonine protein kinase
AC20117_15370	COG2815	serine threonine protein kinase
AC20117_15380	COG0596	Alpha beta hydrolase
AC20117_15390	COG3485	protocatechuate 3,4-dioxygenase
AC20117_15395	COG0667	Aldo Keto reductase
AC20117_15405	COG4214	carbohydrate transport
AC20117_15415	COG4213	ABC transporter substrate-binding protein
AC20117_15435	COG0673	inositol 2-dehydrogenase activity
AC20117_15445	COG0673	inositol 2-dehydrogenase activity
AC20117_15465	COG2814	Major facilitator Superfamily
AC20117_15470	COG1940	carbohydrate kinase activity
AC20117_15480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC20117_15490	COG3962	Belongs to the TPP enzyme family
AC20117_15500	COG1082	Xylose isomerase domain protein TIM barrel
AC20117_15505	COG0673	inositol 2-dehydrogenase activity
AC20117_15510	COG1082	Xylose isomerase domain protein TIM barrel
AC20117_15515	COG2814	Major facilitator Superfamily
AC20117_15525	COG2814	Major facilitator Superfamily
AC20117_15530	COG1609	Transcriptional regulator
AC20117_15535	COG1942	4-Oxalocrotonate Tautomerase
AC20117_15540	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_15545	COG0673	inositol 2-dehydrogenase activity
AC20117_15555	COG3718	enzyme involved in inositol metabolism
AC20117_15570	COG1172	Belongs to the binding-protein-dependent transport system permease family
AC20117_15580	COG0673	inositol 2-dehydrogenase activity
AC20117_15590	COG0673	inositol 2-dehydrogenase activity
AC20117_15600	COG0673	inositol 2-dehydrogenase activity
AC20117_15605	COG1609	Transcriptional regulator
AC20117_15610	COG2271	Major facilitator Superfamily
AC20117_15625	COG2326	polyphosphate kinase activity
AC20117_15640	COG0514	ATP-dependent DNA helicase (RecQ)
AC20117_15645	COG1522	sequence-specific DNA binding
AC20117_15710	COG4325	translation initiation factor activity
AC20117_15715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC20117_15730	COG0471	metal ion transport
AC20117_15760	COG5401	PFAM Sporulation and spore germination
AC20117_15815	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AC20117_15825	COG2234	aminopeptidase activity
AC20117_15825	COG4935	Belongs to the peptidase S8 family
AC20117_15840	COG5002	protein histidine kinase activity
AC20117_15845	COG0745	RESPONSE REGULATOR receiver
AC20117_15855	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AC20117_15865	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AC20117_15870	COG5002	protein histidine kinase activity
AC20117_15880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC20117_15900	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_15920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AC20117_15920	COG1648	precorrin-2 dehydrogenase activity
AC20117_15925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC20117_15940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC20117_15950	COG0484	heat shock protein binding
AC20117_15980	COG2814	Major facilitator Superfamily
AC20117_15985	COG0477	Major facilitator Superfamily
AC20117_15990	COG2261	transglycosylase associated protein
AC20117_15995	COG2385	sporulation resulting in formation of a cellular spore
AC20117_15995	COG2247	cell wall binding repeat
AC20117_16000	COG4770	biotin carboxylase activity
AC20117_16005	COG0515	serine threonine protein kinase
AC20117_16005	COG2815	serine threonine protein kinase
AC20117_16015	COG0424	maF-like protein
AC20117_16045	COG0702	epimerase
AC20117_16055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AC20117_16100	COG0714	Associated with various cellular activities
AC20117_16140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AC20117_16160	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AC20117_16165	COG0154	amidase activity
AC20117_16170	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AC20117_16180	COG0438	transferase activity, transferring glycosyl groups
AC20117_16210	COG2124	cytochrome p450
AC20117_16215	COG1063	alcohol dehydrogenase
AC20117_16220	COG0156	8-amino-7-oxononanoate synthase activity
AC20117_16235	COG2986	histidine ammonia-lyase
AC20117_16250	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AC20117_16265	COG1228	amidohydrolase
AC20117_16285	COG2873	o-acetylhomoserine
AC20117_16290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC20117_16300	COG2755	lipolytic protein G-D-S-L family
AC20117_16310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AC20117_16335	COG2801	Transposase and inactivated derivatives
AC20117_16345	COG0423	glycine-tRNA ligase activity
AC20117_16370	COG0358	DNA primase activity
AC20117_16380	COG2723	6-phospho-beta-galactosidase activity
AC20117_16415	COG0052	Belongs to the universal ribosomal protein uS2 family
AC20117_16420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AC20117_16425	COG0528	UMP kinase activity
AC20117_16430	COG0233	cytoplasmic translational termination
AC20117_16445	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC20117_16455	COG3279	Response regulator of the LytR AlgR family
AC20117_16460	COG3275	phosphorelay sensor kinase activity
AC20117_16470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC20117_16475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC20117_16485	COG1522	sequence-specific DNA binding
AC20117_16495	COG0022	dehydrogenase e1 component
AC20117_16500	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC20117_16510	COG1309	transcriptional regulator
AC20117_16515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AC20117_16525	COG1960	acyl-CoA dehydrogenase activity
AC20117_16555	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AC20117_16560	COG0750	zinc metalloprotease
AC20117_16575	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AC20117_16585	COG0442	prolyl-tRNA aminoacylation
AC20117_16605	COG0779	Required for maturation of 30S ribosomal subunits
AC20117_16620	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AC20117_16620	COG0481	GTPase activity
AC20117_16625	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AC20117_16635	COG0590	tRNA wobble adenosine to inosine editing
AC20117_16640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AC20117_16660	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AC20117_16665	COG1185	polyribonucleotide nucleotidyltransferase activity
AC20117_16670	COG0612	Peptidase, M16
AC20117_16675	COG1115	amino acid carrier protein
AC20117_16690	COG3585	molybdate ion transport
AC20117_16720	COG0315	cyclic pyranopterin monophosphate synthase activity
AC20117_16735	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AC20117_16750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC20117_16755	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AC20117_16760	COG1674	ftsk spoiiie
AC20117_16770	COG1546	Belongs to the CinA family
AC20117_16770	COG1058	Belongs to the CinA family
AC20117_16775	COG1396	sequence-specific DNA binding
AC20117_16790	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AC20117_16795	COG2137	regulation of response to DNA damage stimulus
AC20117_16800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC20117_16805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AC20117_16810	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AC20117_16815	COG2813	Specifically methylates the guanine in position
AC20117_16820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AC20117_16830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC20117_16840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC20117_16845	COG0131	Imidazoleglycerol-phosphate dehydratase
AC20117_16850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AC20117_16855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AC20117_16870	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AC20117_16875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AC20117_16880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AC20117_16885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC20117_16895	COG2814	Major facilitator Superfamily
AC20117_16900	COG0494	nUDIX hydrolase
AC20117_16920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AC20117_16925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC20117_16925	COG0072	phenylalanine-tRNA ligase activity
AC20117_16950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AC20117_16955	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AC20117_16960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AC20117_16965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AC20117_16970	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AC20117_16975	COG1438	arginine binding
AC20117_16980	COG0137	argininosuccinate synthase activity
AC20117_16985	COG0165	Argininosuccinate lyase
AC20117_16995	COG2094	Belongs to the DNA glycosylase MPG family
AC20117_17000	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AC20117_17010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AC20117_17035	COG0647	UMP catabolic process
AC20117_17050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AC20117_17055	COG0497	DNA recombination
AC20117_17060	COG0504	CTP synthase activity
AC20117_17075	COG1051	belongs to the nudix hydrolase family
AC20117_17085	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AC20117_17090	COG2079	MmgE PrpD family protein
AC20117_17110	COG3290	protein histidine kinase activity
AC20117_17115	COG1301	dicarboxylic acid transport
AC20117_17130	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AC20117_17145	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AC20117_17150	COG1160	GTP binding
AC20117_17165	COG0509	glycine decarboxylation via glycine cleavage system
AC20117_17170	COG1716	ATPase activity
AC20117_17195	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AC20117_17200	COG2801	Transposase and inactivated derivatives
AC20117_17235	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AC20117_17240	COG0515	serine threonine protein kinase
AC20117_17240	COG2815	serine threonine protein kinase
AC20117_17245	COG1388	LysM domain
AC20117_17245	COG1705	Flagellar rod assembly protein muramidase FlgJ
AC20117_17270	COG2001	Belongs to the MraZ family
AC20117_17275	COG0275	rRNA processing
AC20117_17285	COG0768	penicillin binding
AC20117_17290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AC20117_17295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AC20117_17300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AC20117_17305	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AC20117_17315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AC20117_17320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC20117_17330	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AC20117_17340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AC20117_17345	COG1799	cell septum assembly
AC20117_17360	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AC20117_17370	COG0587	DNA-directed DNA polymerase activity
AC20117_17380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AC20117_17385	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AC20117_17400	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AC20117_17410	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AC20117_17415	COG0765	amino acid transport
AC20117_17420	COG1126	abc transporter atp-binding protein
AC20117_17445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AC20117_17450	COG0321	lipoyl(octanoyl) transferase activity
AC20117_17460	COG1090	epimerase
AC20117_17465	COG4946	Tricorn protease homolog
AC20117_17465	COG0793	Belongs to the peptidase S41A family
AC20117_17480	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC20117_17485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC20117_17490	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC20117_17510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AC20117_17520	COG0187	DNA topoisomerase II activity
AC20117_17535	COG1271	oxidase subunit
AC20117_17540	COG1294	oxidase, subunit
AC20117_17545	COG4988	ABC transporter
AC20117_17565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AC20117_17600	COG0756	dUTP diphosphatase activity
AC20117_17625	COG0569	domain protein
AC20117_17630	COG0531	amino acid
AC20117_17635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC20117_17640	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AC20117_17645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AC20117_17650	COG3557	Belongs to the UPF0374 family
AC20117_17660	COG3663	DNA glycosylase
AC20117_17665	COG0137	argininosuccinate synthase activity
AC20117_17670	COG0667	Aldo Keto reductase
AC20117_17695	COG1024	Enoyl-CoA hydratase
AC20117_17695	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC20117_17700	COG0183	Belongs to the thiolase family
AC20117_17705	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AC20117_17730	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AC20117_17745	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AC20117_17760	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AC20117_17770	COG3328	transposase activity
AC20117_17815	COG0242	peptide deformylase activity
AC20117_17820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AC20117_17830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AC20117_17850	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AC20117_17850	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AC20117_17860	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AC20117_17865	COG0140	phosphoribosyl-ATP diphosphatase activity
AC20117_17870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AC20117_17875	COG0107	imidazoleglycerol-phosphate synthase activity
AC20117_17885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AC20117_17905	COG0134	indole-3-glycerol-phosphate synthase activity
AC20117_17910	COG0133	tryptophan synthase activity
AC20117_17915	COG0159	tryptophan synthase activity
AC20117_17920	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AC20117_17925	COG0067	glutamate synthase
AC20117_17925	COG0069	glutamate synthase activity
AC20117_17925	COG0070	glutamate synthase
AC20117_17935	COG0469	pyruvate kinase activity
AC20117_17970	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AC20117_17975	COG4867	von Willebrand factor, type A
AC20117_17985	COG3285	dna ligase
AC20117_17985	COG1793	dna ligase
AC20117_18000	COG0477	Major facilitator Superfamily
AC20117_18005	COG1643	Atp-dependent helicase
AC20117_18030	COG0009	L-threonylcarbamoyladenylate synthase
AC20117_18040	COG0174	glutamine synthetase
AC20117_18070	COG2050	protein possibly involved in aromatic compounds catabolism
AC20117_18085	COG4552	Acetyltransferase involved in intracellular survival and related
AC20117_18090	COG0539	negative regulation of cytoplasmic translation
AC20117_18100	COG1739	Uncharacterized protein family UPF0029
AC20117_18105	COG0237	dephospho-CoA kinase activity
AC20117_18105	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AC20117_18110	COG0477	Major facilitator Superfamily
AC20117_18115	COG0556	nucleotide-excision repair
AC20117_18120	COG0861	Integral membrane protein TerC family
AC20117_18125	COG0477	Major facilitator Superfamily
AC20117_18145	COG4106	trans-aconitate 2-methyltransferase activity
AC20117_18155	COG1725	Transcriptional regulator
AC20117_18170	COG0204	Acyl-transferase
AC20117_18170	COG0318	PFAM AMP-dependent synthetase and ligase
AC20117_18175	COG0322	excinuclease ABC activity
AC20117_18180	COG1660	Displays ATPase and GTPase activities
AC20117_18185	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AC20117_18190	COG1481	regulation of sporulation
AC20117_18205	COG0126	phosphoglycerate kinase activity
AC20117_18210	COG0149	triose-phosphate isomerase activity
AC20117_18215	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AC20117_18225	COG0363	glucosamine-6-phosphate deaminase activity
AC20117_18240	COG0166	Belongs to the GPI family
AC20117_18245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AC20117_18255	COG0109	protoheme IX farnesyltransferase activity
AC20117_18260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC20117_18300	COG0396	ATPase activity
AC20117_18305	COG2151	metal-sulfur cluster biosynthetic enzyme
AC20117_18325	COG1122	ATPase activity
AC20117_18330	COG1268	BioY protein
AC20117_18335	COG0488	(ABC) transporter
AC20117_18355	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_18360	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_18365	COG3830	Belongs to the UPF0237 family
AC20117_18365	COG0560	Phosphoserine phosphatase
AC20117_18370	COG1119	ATPase activity
AC20117_18385	COG0254	rRNA binding
AC20117_18400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC20117_18425	COG1305	Transglutaminase-like
AC20117_18430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AC20117_18440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AC20117_18445	COG0297	glycogen (starch) synthase activity
AC20117_18460	COG0183	Belongs to the thiolase family
AC20117_18465	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_18475	COG3844	kynureninase activity
AC20117_18480	COG0438	transferase activity, transferring glycosyl groups
AC20117_18490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC20117_18500	COG3424	synthase
AC20117_18535	COG0366	Alpha amylase catalytic
AC20117_18545	COG0028	Belongs to the TPP enzyme family
AC20117_18575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AC20117_18585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AC20117_18625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_18645	COG0667	Aldo Keto reductase
AC20117_18650	COG1968	undecaprenyl-diphosphatase activity
AC20117_18655	COG0215	cysteine-tRNA ligase activity
AC20117_18665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AC20117_18680	COG1222	aaa ATPase
AC20117_18685	COG4122	O-methyltransferase activity
AC20117_18695	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AC20117_18700	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AC20117_18705	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AC20117_18710	COG0545	Peptidyl-prolyl cis-trans isomerase
AC20117_18720	COG2378	regulation of single-species biofilm formation
AC20117_18730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC20117_18735	COG0805	protein transport
AC20117_18740	COG4581	dead DEAH box helicase
AC20117_18745	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AC20117_18750	COG1216	Glycosyl transferase, family 2
AC20117_18775	COG4946	Tricorn protease homolog
AC20117_18775	COG1506	peptidase
AC20117_18775	COG0823	Involved in the tonB-independent uptake of proteins
AC20117_18780	COG0242	peptide deformylase activity
AC20117_18790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AC20117_18805	COG4974	Belongs to the 'phage' integrase family
AC20117_18825	COG0477	Major facilitator Superfamily
AC20117_18860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AC20117_18865	COG1845	cytochrome c oxidase, subunit III
AC20117_18870	COG2010	Cytochrome c
AC20117_18875	COG0723	plastoquinol--plastocyanin reductase activity
AC20117_18880	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AC20117_18885	COG2188	Transcriptional regulator
AC20117_18895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AC20117_18900	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AC20117_18910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_18920	COG0167	dihydroorotate dehydrogenase activity
AC20117_18930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AC20117_18935	COG1381	Involved in DNA repair and RecF pathway recombination
AC20117_18940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC20117_18945	COG3590	peptidase
AC20117_18950	COG1316	TRANSCRIPTIONal
AC20117_18955	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AC20117_18965	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AC20117_18985	COG0484	heat shock protein binding
AC20117_18990	COG1420	regulation of RNA biosynthetic process
AC20117_19010	COG0481	GTPase activity
AC20117_19020	COG0268	Binds directly to 16S ribosomal RNA
AC20117_19035	COG1596	polysaccharide export
AC20117_19035	COG1555	photosystem II stabilization
AC20117_19040	COG1307	EDD domain protein, DegV family
AC20117_19045	COG0495	leucyl-tRNA aminoacylation
AC20117_19050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AC20117_19075	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AC20117_19085	COG1758	RNA polymerase activity
AC20117_19090	COG0194	GDP metabolic process
AC20117_19095	COG0194	GDP metabolic process
AC20117_19100	COG0284	orotidine-5'-phosphate decarboxylase activity
AC20117_19105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AC20117_19110	COG0505	Belongs to the CarA family
AC20117_19120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC20117_19125	COG0540	Belongs to the ATCase OTCase family
AC20117_19130	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AC20117_19135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC20117_19140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AC20117_19145	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AC20117_19150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AC20117_19155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AC20117_19160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AC20117_19170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AC20117_19175	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AC20117_19190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AC20117_19195	COG1490	D-aminoacyl-tRNA deacylase activity
AC20117_19210	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AC20117_19220	COG0124	histidyl-tRNA synthetase
AC20117_19225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AC20117_19230	COG1196	nuclear chromosome segregation
AC20117_19240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC20117_19250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AC20117_19260	COG2255	four-way junction helicase activity
AC20117_19265	COG0632	four-way junction helicase activity
AC20117_19270	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AC20117_19275	COG0217	transcriptional regulatory protein
AC20117_19280	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AC20117_19285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AC20117_19300	COG0339	signal peptide processing
AC20117_19310	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AC20117_19325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AC20117_19330	COG0587	DNA-directed DNA polymerase activity
AC20117_19355	COG2135	peptidase activity
AC20117_19370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC20117_19420	COG0596	Alpha beta hydrolase
AC20117_19425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AC20117_19435	COG2226	methyltransferase
AC20117_19475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC20117_19480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC20117_19485	COG1780	Probably involved in ribonucleotide reductase function
AC20117_19490	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AC20117_19495	COG0583	DNA-binding transcription factor activity
AC20117_19525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AC20117_19535	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AC20117_19540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AC20117_19545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AC20117_19550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AC20117_19555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AC20117_19560	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AC20117_19560	COG0352	thiamine-phosphate diphosphorylase activity
AC20117_19560	COG0351	phosphomethylpyrimidine kinase
AC20117_19565	COG1530	ribonuclease E activity
AC20117_19575	COG0105	UTP biosynthetic process
AC20117_19585	COG0285	dihydrofolate synthase activity
AC20117_19590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AC20117_19605	COG0525	valine-tRNA ligase activity
AC20117_19610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AC20117_19615	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AC20117_19620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AC20117_19625	COG0740	serine-type endopeptidase activity
AC20117_19630	COG0740	serine-type endopeptidase activity
AC20117_19635	COG0544	peptidyl-prolyl cis-trans isomerase activity
AC20117_19690	COG1946	Acyl-CoA thioesterase
AC20117_19705	COG0629	single-stranded DNA binding
AC20117_19715	COG0438	transferase activity, transferring glycosyl groups
AC20117_19720	COG1904	glucuronate isomerase
AC20117_19725	COG0246	Mannitol dehydrogenase
AC20117_19730	COG4948	Mandelate Racemase Muconate Lactonizing
AC20117_19735	COG3265	gluconokinase activity
AC20117_19740	COG1609	Transcriptional regulator
AC20117_19745	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC20117_19775	COG0438	transferase activity, transferring glycosyl groups
AC20117_19785	COG2755	lipolytic protein G-D-S-L family
AC20117_19785	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AC20117_19800	COG0438	transferase activity, transferring glycosyl groups
AC20117_19805	COG0438	transferase activity, transferring glycosyl groups
AC20117_19815	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AC20117_19820	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AC20117_19840	COG1134	teichoic acid transport
AC20117_19870	COG0242	peptide deformylase activity
AC20117_19895	COG3594	Acyltransferase
AC20117_19915	COG1579	Zn-ribbon protein possibly nucleic acid-binding
AC20117_19920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AC20117_19925	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AC20117_19935	COG1045	serine acetyltransferase
AC20117_19945	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AC20117_19975	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AC20117_19990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC20117_19995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AC20117_20010	COG4974	Belongs to the 'phage' integrase family
AC20117_20020	COG0606	chelatase, subunit chli
AC20117_20025	COG0792	nuclease activity
AC20117_20035	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AC20117_20045	COG0681	Belongs to the peptidase S26 family
AC20117_20050	COG0335	large ribosomal subunit rRNA binding
AC20117_20055	COG0336	Belongs to the RNA methyltransferase TrmD family
AC20117_20060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AC20117_20065	COG1837	Belongs to the UPF0109 family
AC20117_20070	COG0228	four-way junction DNA binding
AC20117_20080	COG2514	catechol 2,3-dioxygenase activity
AC20117_20105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AC20117_20120	COG2814	Major facilitator Superfamily
AC20117_20145	COG0519	Catalyzes the synthesis of GMP from XMP
AC20117_20145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC20117_20150	COG1196	nuclear chromosome segregation
AC20117_20155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC20117_20160	COG0318	PFAM AMP-dependent synthetase and ligase
AC20117_20165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC20117_20190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AC20117_20195	COG0571	ribonuclease III activity
AC20117_20200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AC20117_20210	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AC20117_20215	COG0436	Aminotransferase
AC20117_20230	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AC20117_20235	COG1461	Dihydroxyacetone kinase
AC20117_20240	COG1316	TRANSCRIPTIONal
AC20117_20250	COG1181	Belongs to the D-alanine--D-alanine ligase family
AC20117_20255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AC20117_20265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AC20117_20270	COG0066	3-isopropylmalate dehydratase activity
AC20117_20275	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AC20117_20280	COG1414	Transcriptional regulator
AC20117_20315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC20117_20325	COG2197	response regulator
AC20117_20340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC20117_20345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AC20117_20350	COG0473	3-isopropylmalate dehydrogenase activity
AC20117_20355	COG4585	Histidine kinase
AC20117_20360	COG2197	response regulator
AC20117_20390	COG0577	efflux transmembrane transporter activity
AC20117_20390	COG1136	(ABC) transporter
AC20117_20405	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AC20117_20410	COG0440	acetolactate synthase activity
AC20117_20420	COG0129	dihydroxy-acid dehydratase activity
AC20117_20440	COG2133	pyrroloquinoline quinone binding
AC20117_20470	COG3328	transposase activity
AC20117_20480	COG1278	Cold shock
AC20117_20525	COG0789	Transcriptional regulator
AC20117_20535	COG2814	Major facilitator Superfamily
AC20117_20630	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AC20117_20635	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC20117_20645	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AC20117_20655	COG0713	ATP synthesis coupled electron transport
AC20117_20660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC20117_20685	COG2124	cytochrome p450
AC20117_20690	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AC20117_20710	COG3328	transposase activity
AC20117_20825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC20117_20825	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AC20117_20890	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AC20117_20955	COG0785	Cytochrome C biogenesis protein
AC20117_20960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC20117_20970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AC20117_20980	COG2132	Multicopper oxidase
AC20117_21010	COG0739	heme binding
AC20117_21020	COG1937	Protein conserved in bacteria
AC20117_21130	COG2197	response regulator
AC20117_21150	COG4208	sulfate ABC transporter
AC20117_21155	COG3842	ATPase activity
AC20117_21205	COG0457	Tetratricopeptide repeat
AC20117_21240	COG0492	ferredoxin-NADP+ reductase activity
AC20117_21255	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AC20117_21265	COG0277	FAD linked oxidase domain protein
AC20117_21270	COG2267	carboxylic ester hydrolase activity
AC20117_21305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AC20117_21320	COG0747	negative chemotaxis
AC20117_21325	COG0579	oxidoreductase
AC20117_21330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC20117_21335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_21345	COG1305	Transglutaminase-like
AC20117_21355	COG1104	cysteine desulfurase activity
AC20117_21365	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AC20117_21370	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AC20117_21385	COG1113	amino acid transport
AC20117_21395	COG0022	dehydrogenase e1 component
AC20117_21400	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC20117_21410	COG0515	serine threonine protein kinase
AC20117_21425	COG1802	Transcriptional regulator
AC20117_21455	COG3226	Transcriptional regulator
AC20117_21475	COG0477	Major facilitator Superfamily
AC20117_21490	COG0419	ATPase involved in DNA repair
AC20117_21495	COG0420	3'-5' exonuclease activity
AC20117_21510	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_21525	COG1131	(ABC) transporter
AC20117_21530	COG2188	Transcriptional regulator
AC20117_21540	COG0586	Pfam SNARE associated Golgi protein
AC20117_21545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AC20117_21550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AC20117_21555	COG1234	tRNA 3'-trailer cleavage
AC20117_21560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AC20117_21570	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AC20117_21575	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AC20117_21580	COG1335	isochorismatase
AC20117_21605	COG1131	(ABC) transporter
AC20117_21610	COG1902	pentaerythritol trinitrate reductase activity
AC20117_21635	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AC20117_21655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AC20117_21660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AC20117_21665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AC20117_21670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AC20117_21675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AC20117_21680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AC20117_21685	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AC20117_21690	COG0356	it plays a direct role in the translocation of protons across the membrane
AC20117_21710	COG1086	Polysaccharide biosynthesis protein
AC20117_21720	COG2890	protein-(glutamine-N5) methyltransferase activity
AC20117_21725	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AC20117_21735	COG0083	homoserine kinase activity
AC20117_21740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AC20117_21745	COG0460	homoserine dehydrogenase
AC20117_21750	COG0019	diaminopimelate decarboxylase activity
AC20117_21755	COG0018	arginyl-trna synthetase
AC20117_21795	COG1643	Atp-dependent helicase
AC20117_21800	COG0537	adenosine 5'-monophosphoramidase activity
AC20117_21805	COG1064	alcohol dehydrogenase
AC20117_21825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AC20117_21830	COG1121	(ABC) transporter
AC20117_21835	COG0803	Belongs to the bacterial solute-binding protein 9 family
AC20117_21845	COG1253	flavin adenine dinucleotide binding
AC20117_21855	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC20117_21855	COG0567	Dehydrogenase, E1 component
AC20117_21870	COG1595	DNA-templated transcription, initiation
AC20117_21880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AC20117_21890	COG0483	inositol monophosphate 1-phosphatase activity
AC20117_21895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AC20117_21905	COG0803	Belongs to the bacterial solute-binding protein 9 family
AC20117_21910	COG1121	(ABC) transporter
AC20117_21915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AC20117_21920	COG1321	iron dependent repressor
AC20117_21925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AC20117_21930	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AC20117_21935	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AC20117_21955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AC20117_21970	COG2884	Cell division ATP-binding protein ftsE
AC20117_21980	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AC20117_22145	COG1129	ABC transporter
AC20117_22150	COG1172	Belongs to the binding-protein-dependent transport system permease family
AC20117_22170	COG0154	amidase activity
AC20117_22175	COG1414	Transcriptional regulator
AC20117_22200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_22205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_22210	COG1116	anion transmembrane transporter activity
AC20117_22230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC20117_22245	COG0656	L-ascorbic acid biosynthetic process
AC20117_22250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC20117_22290	COG0861	Integral membrane protein TerC family
AC20117_22305	COG2856	Zn peptidase
AC20117_22330	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AC20117_22330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC20117_22335	COG2188	Transcriptional regulator
AC20117_22350	COG2814	Major facilitator Superfamily
AC20117_22355	COG1937	Protein conserved in bacteria
AC20117_22360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC20117_22375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC20117_22385	COG0861	Integral membrane protein TerC family
AC20117_22395	COG1253	flavin adenine dinucleotide binding
AC20117_22400	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AC20117_22405	COG0530	calcium, potassium:sodium antiporter activity
AC20117_22445	COG1192	Involved in chromosome partitioning
AC20117_22560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_22585	COG1609	Transcriptional regulator
AC20117_22590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC20117_22595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AC20117_22640	COG0066	3-isopropylmalate dehydratase activity
AC20117_22645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AC20117_22650	COG0473	3-isopropylmalate dehydrogenase activity
AC20117_22655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_22660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_22670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC20117_22735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_22745	COG1335	isochorismatase
AC20117_22755	COG0656	L-ascorbic acid biosynthetic process
AC20117_22760	COG4638	Rieske (2fe-2S)
AC20117_22815	COG4974	Belongs to the 'phage' integrase family
AC20117_22905	COG1053	succinate dehydrogenase
AC20117_22950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_22955	COG1116	anion transmembrane transporter activity
AC20117_22955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC20117_22960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC20117_22965	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AC20117_22970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC20117_22990	COG0252	asparaginase activity
AC20117_23000	COG0318	PFAM AMP-dependent synthetase and ligase
AC20117_23010	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AC20117_23015	COG3328	transposase activity
AC20117_23040	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_23060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_23070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC20117_23085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC20117_23090	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_23095	COG1522	sequence-specific DNA binding
AC20117_23140	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AC20117_23150	COG2801	Transposase and inactivated derivatives
AC20117_23170	COG2176	DNA-directed DNA polymerase activity