locus-tag	class	description
J5251_00005	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J5251_00025	COG2003	Belongs to the UPF0758 family
J5251_00030	COG0789	Transcriptional regulator
J5251_00035	COG0484	heat shock protein binding
J5251_00040	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J5251_00045	COG0443	Heat shock 70 kDa protein
J5251_00050	COG2409	Drug exporters of the RND superfamily
J5251_00055	COG0110	maltose O-acetyltransferase activity
J5251_00060	COG2226	methyltransferase
J5251_00070	COG1280	lysine exporter protein (LysE YggA)
J5251_00075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J5251_00095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J5251_00110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J5251_00125	COG4172	Belongs to the ABC transporter superfamily
J5251_00130	COG4721	ABC-type cobalt transport system, permease component
J5251_00140	COG1320	monovalent cation:proton antiporter activity
J5251_00145	COG2212	antiporter activity
J5251_00155	COG0651	ATP synthesis coupled electron transport
J5251_00160	COG1006	Multisubunit Na H antiporter MnhC subunit
J5251_00165	COG2111	Na H antiporter
J5251_00165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J5251_00175	COG0717	Belongs to the dCTP deaminase family
J5251_00185	COG3483	tryptophan 2,3-dioxygenase activity
J5251_00195	COG0475	glutathione-regulated potassium exporter activity
J5251_00235	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
J5251_00240	COG0679	Auxin Efflux Carrier
J5251_00245	COG0433	COG0433 Predicted ATPase
J5251_00260	COG3336	cytochrome c oxidase
J5251_00265	COG0776	regulation of translation
J5251_00270	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J5251_00275	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J5251_00280	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J5251_00315	COG1742	UPF0060 membrane protein
J5251_00325	COG1120	ATPase activity
J5251_00330	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5251_00335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5251_00340	COG2267	carboxylic ester hydrolase activity
J5251_00365	COG0789	Transcriptional regulator
J5251_00370	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J5251_00375	COG0435	Glutathione S-transferase
J5251_00380	COG2031	fatty acid transporter
J5251_00385	COG2807	transmembrane transport
J5251_00405	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J5251_00415	COG0519	Catalyzes the synthesis of GMP from XMP
J5251_00420	COG0589	response to stress
J5251_00430	COG0667	Aldo Keto reductase
J5251_00450	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J5251_00465	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_00480	COG0509	glycine decarboxylation via glycine cleavage system
J5251_00485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J5251_00490	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J5251_00490	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J5251_00500	COG2807	transmembrane transport
J5251_00515	COG2814	Major facilitator Superfamily
J5251_00530	COG1609	Transcriptional regulator
J5251_00550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5251_00575	COG1012	belongs to the aldehyde dehydrogenase family
J5251_00590	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
J5251_00590	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J5251_00595	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
J5251_00600	COG0438	transferase activity, transferring glycosyl groups
J5251_00610	COG0859	PFAM glycosyl transferase family 9
J5251_00625	COG1191	sigma factor activity
J5251_00650	COG1295	ribonuclease BN
J5251_00660	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_00665	COG0436	Aminotransferase
J5251_00675	COG0598	Magnesium transport protein CorA
J5251_00700	COG0477	Major facilitator Superfamily
J5251_00720	COG3634	alkyl hydroperoxide reductase activity
J5251_00725	COG1254	Belongs to the acylphosphatase family
J5251_00735	COG1597	lipid kinase activity
J5251_00740	COG1309	transcriptional regulator
J5251_00750	COG0589	response to stress
J5251_00770	COG3290	protein histidine kinase activity
J5251_00775	COG4565	transcriptional regulatory protein
J5251_00790	COG0412	Dienelactone hydrolase
J5251_00795	COG0768	penicillin binding
J5251_00820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5251_00825	COG0765	amino acid transport
J5251_00830	COG1126	abc transporter atp-binding protein
J5251_00845	COG3135	benzoate transporter
J5251_00855	COG0655	NAD(P)H dehydrogenase (quinone) activity
J5251_00865	COG1793	dna ligase
J5251_00875	COG0667	Aldo Keto reductase
J5251_00900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5251_00905	COG4948	Mandelate Racemase Muconate Lactonizing
J5251_00910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J5251_00920	COG4608	Belongs to the ABC transporter superfamily
J5251_00925	COG0444	Belongs to the ABC transporter superfamily
J5251_00930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5251_00935	COG0601	transmembrane transport
J5251_00940	COG0747	negative chemotaxis
J5251_00945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J5251_00950	COG0589	response to stress
J5251_00955	COG1414	Transcriptional regulator
J5251_00960	COG1012	belongs to the aldehyde dehydrogenase family
J5251_00965	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
J5251_00985	COG4989	oxidoreductase activity
J5251_01000	COG2124	cytochrome p450
J5251_01010	COG1414	Transcriptional regulator
J5251_01030	COG1960	acyl-CoA dehydrogenase activity
J5251_01035	COG0318	PFAM AMP-dependent synthetase and ligase
J5251_01060	COG0069	glutamate synthase activity
J5251_01065	COG4335	DNA alkylation repair
J5251_01100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J5251_01145	COG1116	anion transmembrane transporter activity
J5251_01160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5251_01165	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
J5251_01175	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J5251_01185	COG2267	carboxylic ester hydrolase activity
J5251_01190	COG1414	Transcriptional regulator
J5251_01200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J5251_01205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
J5251_01210	COG2610	gluconate transmembrane transporter activity
J5251_01230	COG1802	Transcriptional regulator
J5251_01245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5251_01250	COG0477	Major facilitator Superfamily
J5251_01255	COG2368	4-hydroxyphenylacetate
J5251_01270	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
J5251_01275	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
J5251_01280	COG1116	anion transmembrane transporter activity
J5251_01280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5251_01285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5251_01290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5251_01295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5251_01300	COG1012	belongs to the aldehyde dehydrogenase family
J5251_01305	COG1234	tRNA 3'-trailer cleavage
J5251_01310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J5251_01315	COG0179	Fumarylacetoacetate (FAA) hydrolase
J5251_01320	COG1802	Transcriptional regulator
J5251_01335	COG1940	carbohydrate kinase activity
J5251_01350	COG0640	Transcriptional regulator
J5251_01360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J5251_01370	COG0640	Transcriptional regulator
J5251_01395	COG2072	flavoprotein involved in K transport
J5251_01400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J5251_01410	COG0747	negative chemotaxis
J5251_01420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5251_01470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
J5251_01475	COG0247	lactate metabolic process
J5251_01475	COG0277	FAD linked oxidase domain protein
J5251_01485	COG0006	proline dipeptidase activity
J5251_01490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J5251_01495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J5251_01500	COG0477	Major facilitator Superfamily
J5251_01510	COG0686	Belongs to the AlaDH PNT family
J5251_01535	COG1595	DNA-templated transcription, initiation
J5251_01550	COG0438	transferase activity, transferring glycosyl groups
J5251_01555	COG0463	Glycosyl transferase, family 2
J5251_01580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5251_01600	COG2197	response regulator
J5251_01605	COG2814	Major facilitator Superfamily
J5251_01620	COG4638	Rieske (2fe-2S)
J5251_01625	COG3135	benzoate transporter
J5251_01630	COG1869	D-ribose catabolic process
J5251_01635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J5251_01640	COG1879	ABC-type sugar transport system periplasmic component
J5251_01645	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5251_01650	COG1129	ABC transporter
J5251_01655	COG1609	Transcriptional regulator
J5251_01665	COG1012	belongs to the aldehyde dehydrogenase family
J5251_01680	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
J5251_01690	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
J5251_01700	COG1063	alcohol dehydrogenase
J5251_01705	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_01710	COG0800	Aldolase
J5251_01730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J5251_01735	COG0604	alcohol dehydrogenase
J5251_01740	COG1796	DNA polymerase
J5251_01740	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
J5251_01780	COG0443	Heat shock 70 kDa protein
J5251_01795	COG2186	Transcriptional regulator
J5251_01805	COG1027	Aspartate ammonia-lyase
J5251_01820	COG0640	Transcriptional regulator
J5251_01825	COG2814	Major facilitator Superfamily
J5251_01835	COG2851	Citrate transporter
J5251_01840	COG3290	protein histidine kinase activity
J5251_01845	COG4565	transcriptional regulatory protein
J5251_01855	COG3387	PFAM Glycoside hydrolase 15-related
J5251_01875	COG0667	Aldo Keto reductase
J5251_01880	COG0673	inositol 2-dehydrogenase activity
J5251_01890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
J5251_01890	COG0517	IMP dehydrogenase activity
J5251_01890	COG0617	tRNA 3'-terminal CCA addition
J5251_01900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
J5251_01910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J5251_01920	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
J5251_01930	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_01950	COG1012	belongs to the aldehyde dehydrogenase family
J5251_01960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5251_01975	COG0583	DNA-binding transcription factor activity
J5251_01980	COG1522	sequence-specific DNA binding
J5251_01985	COG1280	lysine exporter protein (LysE YggA)
J5251_01990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J5251_02005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J5251_02020	COG3833	ABC-type maltose transport systems, permease component
J5251_02025	COG1175	transmembrane transport
J5251_02030	COG1653	transport
J5251_02035	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J5251_02085	COG0583	DNA-binding transcription factor activity
J5251_02090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J5251_02110	COG3485	protocatechuate 3,4-dioxygenase
J5251_02115	COG4638	Rieske (2fe-2S)
J5251_02140	COG4829	muconolactone delta-isomerase
J5251_02145	COG4948	Mandelate Racemase Muconate Lactonizing
J5251_02150	COG0583	DNA-binding transcription factor activity
J5251_02165	COG2050	protein possibly involved in aromatic compounds catabolism
J5251_02170	COG0656	L-ascorbic acid biosynthetic process
J5251_02185	COG1278	Cold shock
J5251_02230	COG1234	tRNA 3'-trailer cleavage
J5251_02270	COG2211	Major facilitator Superfamily
J5251_02285	COG2301	Belongs to the HpcH HpaI aldolase family
J5251_02315	COG1960	acyl-CoA dehydrogenase activity
J5251_02325	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_02335	COG1116	anion transmembrane transporter activity
J5251_02340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5251_02345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5251_02350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5251_02370	COG2197	response regulator
J5251_02375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J5251_02385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J5251_02390	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5251_02395	COG0022	dehydrogenase e1 component
J5251_02405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J5251_02410	COG1950	PFAM Membrane protein of
J5251_02415	COG2223	nitrite transmembrane transporter activity
J5251_02420	COG0243	molybdopterin cofactor binding
J5251_02425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J5251_02440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J5251_02455	COG1607	acyl-coa hydrolase
J5251_02460	COG0436	Aminotransferase
J5251_02465	COG0589	response to stress
J5251_02475	COG1725	Transcriptional regulator
J5251_02480	COG0589	response to stress
J5251_02500	COG0583	DNA-binding transcription factor activity
J5251_02505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5251_02545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J5251_02560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J5251_02565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J5251_02570	COG0492	ferredoxin-NADP+ reductase activity
J5251_02580	COG0477	Major facilitator Superfamily
J5251_02585	COG1937	Protein conserved in bacteria
J5251_02590	COG2217	Heavy metal translocating P-type atpase
J5251_02610	COG2271	Major facilitator Superfamily
J5251_02615	COG0697	spore germination
J5251_02665	COG2890	protein-(glutamine-N5) methyltransferase activity
J5251_02705	COG0577	efflux transmembrane transporter activity
J5251_02705	COG1136	(ABC) transporter
J5251_02770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J5251_02800	COG0583	DNA-binding transcription factor activity
J5251_02805	COG1053	succinate dehydrogenase
J5251_02810	COG0583	DNA-binding transcription factor activity
J5251_02860	COG2814	Major facilitator Superfamily
J5251_02890	COG0531	amino acid
J5251_02905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J5251_02910	COG1929	Belongs to the glycerate kinase type-1 family
J5251_02915	COG3960	tartronate-semialdehyde synthase activity
J5251_02920	COG2084	Dehydrogenase
J5251_02925	COG3622	Belongs to the hyi family
J5251_02935	COG3655	Transcriptional regulator
J5251_02940	COG3257	ureidoglycine aminohydrolase activity
J5251_02950	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J5251_02960	COG1414	Transcriptional regulator
J5251_02965	COG0590	tRNA wobble adenosine to inosine editing
J5251_02975	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
J5251_02975	COG3608	succinylglutamate desuccinylase aspartoacylase
J5251_02985	COG2080	2 iron, 2 sulfur cluster binding
J5251_02985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J5251_02990	COG3949	Membrane
J5251_03015	COG0405	Gamma-glutamyltransferase
J5251_03020	COG1335	isochorismatase
J5251_03055	COG0723	plastoquinol--plastocyanin reductase activity
J5251_03065	COG2233	PERMEase
J5251_03095	COG0589	response to stress
J5251_03105	COG1802	Transcriptional regulator
J5251_03110	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J5251_03125	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
J5251_03135	COG0469	pyruvate kinase activity
J5251_03150	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
J5251_03180	COG3583	domain protein
J5251_03185	COG1045	serine acetyltransferase
J5251_03210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J5251_03255	COG2409	Drug exporters of the RND superfamily
J5251_03260	COG2084	Dehydrogenase
J5251_03275	COG0305	Participates in initiation and elongation during chromosome replication
J5251_03295	COG0384	phenazine biosynthesis protein PhzF
J5251_03305	COG0359	binds to the 23S rRNA
J5251_03310	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J5251_03320	COG0360	Binds together with S18 to 16S ribosomal RNA
J5251_03330	COG2197	response regulator
J5251_03335	COG4585	Histidine kinase
J5251_03350	COG0738	Major facilitator superfamily
J5251_03355	COG0488	(ABC) transporter
J5251_03365	COG2197	response regulator
J5251_03370	COG0179	Fumarylacetoacetate (FAA) hydrolase
J5251_03385	COG3850	Histidine kinase
J5251_03395	COG0577	efflux transmembrane transporter activity
J5251_03395	COG1136	(ABC) transporter
J5251_03400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J5251_03415	COG1083	cytidylyl-transferase
J5251_03420	COG2089	acid synthase
J5251_03425	COG1215	transferase activity, transferring glycosyl groups
J5251_03485	COG2124	cytochrome p450
J5251_03495	COG2986	histidine ammonia-lyase
J5251_03505	COG0765	amino acid transport
J5251_03510	COG1126	abc transporter atp-binding protein
J5251_03520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J5251_03535	COG2814	Major facilitator Superfamily
J5251_03560	COG0477	Major facilitator Superfamily
J5251_03565	COG1234	tRNA 3'-trailer cleavage
J5251_03570	COG0583	DNA-binding transcription factor activity
J5251_03580	COG4770	biotin carboxylase activity
J5251_03585	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
J5251_03590	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
J5251_03595	COG1914	H( )-stimulated, divalent metal cation uptake system
J5251_03600	COG4336	lyase activity
J5251_03640	COG2759	Belongs to the formate--tetrahydrofolate ligase family
J5251_03665	COG1129	ABC transporter
J5251_03690	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_03695	COG0531	amino acid
J5251_03720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J5251_03785	COG1473	amidohydrolase
J5251_03795	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
J5251_03810	COG1609	Transcriptional regulator
J5251_03825	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J5251_03830	COG1953	Uracil, thiamine, allantoin
J5251_03840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J5251_03845	COG2807	transmembrane transport
J5251_03850	COG0252	asparaginase activity
J5251_03885	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
J5251_03930	COG0765	amino acid transport
J5251_03950	COG2072	flavoprotein involved in K transport
J5251_03960	COG0477	Major facilitator Superfamily
J5251_03965	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_03970	COG1414	Transcriptional regulator
J5251_03975	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_03980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J5251_03990	COG0477	Major facilitator Superfamily
J5251_04020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J5251_04030	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_04045	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
J5251_04050	COG1228	amidohydrolase
J5251_04060	COG1473	amidohydrolase
J5251_04065	COG0477	Major facilitator Superfamily
J5251_04080	COG0659	secondary active sulfate transmembrane transporter activity
J5251_04110	COG1140	nitrate reductase beta subunit
J5251_04145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5251_04150	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
J5251_04165	COG0588	phosphoglycerate mutase activity
J5251_04170	COG0617	tRNA 3'-terminal CCA addition
J5251_04190	COG0492	ferredoxin-NADP+ reductase activity
J5251_04195	COG3118	belongs to the thioredoxin family
J5251_04200	COG3409	Peptidoglycan-binding domain 1 protein
J5251_04200	COG0860	N-Acetylmuramoyl-L-alanine amidase
J5251_04210	COG1192	Involved in chromosome partitioning
J5251_04215	COG0357	Ribosomal RNA small subunit methyltransferase G
J5251_04225	COG0706	membrane insertase activity
J5251_04230	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J5251_04235	COG0594	ribonuclease P activity
J5251_04240	COG0230	Belongs to the bacterial ribosomal protein bL34 family
J5251_04245	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J5251_04250	COG0592	DNA-directed DNA polymerase activity
J5251_04255	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
J5251_04260	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J5251_04265	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
J5251_04270	COG0187	DNA topoisomerase II activity
J5251_04275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J5251_04280	COG3266	domain, Protein
J5251_04300	COG1215	transferase activity, transferring glycosyl groups
J5251_04315	COG0457	Tetratricopeptide repeat
J5251_04315	COG0705	Rhomboid family
J5251_04335	COG3764	Sortase (surface protein transpeptidase)
J5251_04350	COG0515	serine threonine protein kinase
J5251_04350	COG2815	serine threonine protein kinase
J5251_04355	COG0515	serine threonine protein kinase
J5251_04375	COG1716	ATPase activity
J5251_04380	COG1716	ATPase activity
J5251_04390	COG0346	lactoylglutathione lyase activity
J5251_04405	COG0483	inositol monophosphate 1-phosphatase activity
J5251_04410	COG1024	Enoyl-CoA hydratase
J5251_04415	COG2353	YceI-like domain
J5251_04430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J5251_04450	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
J5251_04460	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
J5251_04465	COG1609	Transcriptional regulator
J5251_04480	COG0561	phosphatase activity
J5251_04485	COG0584	glycerophosphoryl diester phosphodiesterase
J5251_04490	COG1929	Belongs to the glycerate kinase type-1 family
J5251_04510	COG2233	PERMEase
J5251_04515	COG0778	Nitroreductase
J5251_04520	COG0033	Phosphoglucomutase
J5251_04530	COG0640	Transcriptional regulator
J5251_04535	COG0798	PFAM Bile acid sodium symporter
J5251_04540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J5251_04545	COG0492	ferredoxin-NADP+ reductase activity
J5251_04555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J5251_04560	COG2072	flavoprotein involved in K transport
J5251_04565	COG3104	oligopeptide transport
J5251_04570	COG0154	amidase activity
J5251_04575	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J5251_04580	COG3340	Belongs to the peptidase S51 family
J5251_04585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J5251_04590	COG0077	Prephenate dehydratase
J5251_04605	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J5251_04610	COG0561	phosphatase activity
J5251_04630	COG2027	D-alanyl-D-alanine carboxypeptidase
J5251_04640	COG0037	tRNA processing
J5251_04650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J5251_04655	COG0302	gtp cyclohydrolase
J5251_04665	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J5251_04670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J5251_04695	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J5251_04700	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J5251_04720	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
J5251_04730	COG3237	CsbD-like
J5251_04750	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
J5251_04780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J5251_04785	COG0306	phosphate transporter
J5251_04810	COG0456	acetyltransferase
J5251_04815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
J5251_04820	COG1917	Cupin 2, conserved barrel domain protein
J5251_04825	COG5285	phytanoyl-CoA dioxygenase
J5251_04835	COG1012	belongs to the aldehyde dehydrogenase family
J5251_04840	COG0831	urea catabolic process
J5251_04845	COG0832	Belongs to the urease beta subunit family
J5251_04850	COG0804	urea catabolic process
J5251_04855	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
J5251_04860	COG0830	nickel cation binding
J5251_04865	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
J5251_04870	COG0829	nickel cation binding
J5251_04875	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
J5251_04880	COG0531	amino acid
J5251_04905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J5251_04910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J5251_04910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J5251_04910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5251_04920	COG1349	DNA-binding transcription factor activity
J5251_04945	COG2733	membrane
J5251_04950	COG0584	glycerophosphoryl diester phosphodiesterase
J5251_04955	COG3387	PFAM Glycoside hydrolase 15-related
J5251_04975	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J5251_04985	COG4122	O-methyltransferase activity
J5251_04995	COG2252	PERMEase
J5251_05000	COG2372	response to copper ion
J5251_05075	COG1653	transport
J5251_05080	COG1175	transmembrane transport
J5251_05085	COG0395	ABC-type sugar transport system, permease component
J5251_05090	COG1609	Transcriptional regulator
J5251_05100	COG4941	Belongs to the sigma-70 factor family
J5251_05115	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
J5251_05145	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5251_05150	COG1129	ABC transporter
J5251_05155	COG1940	carbohydrate kinase activity
J5251_05160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J5251_05210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J5251_05225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J5251_05245	COG1832	CoA-binding protein
J5251_05265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J5251_05270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5251_05280	COG1116	anion transmembrane transporter activity
J5251_05290	COG1832	CoA-binding protein
J5251_05305	COG1113	amino acid transport
J5251_05320	COG2315	Protein conserved in bacteria
J5251_05345	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J5251_05350	COG0047	phosphoribosylformylglycinamidine synthase activity
J5251_05355	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J5251_05380	COG1846	Transcriptional regulator
J5251_05400	COG1126	abc transporter atp-binding protein
J5251_05405	COG0765	amino acid transport
J5251_05410	COG0765	amino acid transport
J5251_05425	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J5251_05495	COG2814	Major facilitator Superfamily
J5251_05525	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J5251_05545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J5251_05550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J5251_05555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J5251_05560	COG0280	phosphate acetyltransferase
J5251_05570	COG2855	membrane
J5251_05580	COG0477	Major facilitator Superfamily
J5251_05630	COG1414	Transcriptional regulator
J5251_05665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J5251_05695	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_05700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J5251_05765	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J5251_05835	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J5251_05845	COG1012	belongs to the aldehyde dehydrogenase family
J5251_05850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J5251_05875	COG1063	alcohol dehydrogenase
J5251_05885	COG0640	Transcriptional regulator
J5251_05905	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
J5251_05915	COG1879	ABC-type sugar transport system periplasmic component
J5251_05920	COG1129	ABC transporter
J5251_05925	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5251_05930	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5251_05945	COG2807	transmembrane transport
J5251_05985	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J5251_05995	COG1609	Transcriptional regulator
J5251_06000	COG1957	nucleoside hydrolase
J5251_06005	COG0477	Major facilitator Superfamily
J5251_06010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J5251_06030	COG1414	Transcriptional regulator
J5251_06035	COG2124	cytochrome p450
J5251_06060	COG2124	cytochrome p450
J5251_06085	COG1234	tRNA 3'-trailer cleavage
J5251_06090	COG1012	belongs to the aldehyde dehydrogenase family
J5251_06100	COG1414	Transcriptional regulator
J5251_06105	COG2271	Major facilitator Superfamily
J5251_06115	COG2124	cytochrome p450
J5251_06135	COG2135	peptidase activity
J5251_06145	COG0492	ferredoxin-NADP+ reductase activity
J5251_06160	COG2860	membrane
J5251_06175	COG0366	Alpha amylase catalytic
J5251_06185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J5251_06190	COG1113	amino acid transport
J5251_06210	COG2130	NADP-dependent
J5251_06220	COG0277	FAD linked oxidase domain protein
J5251_06230	COG0583	DNA-binding transcription factor activity
J5251_06250	COG1942	4-Oxalocrotonate Tautomerase
J5251_06255	COG1012	belongs to the aldehyde dehydrogenase family
J5251_06260	COG0596	Alpha beta hydrolase
J5251_06275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5251_06280	COG1802	Transcriptional regulator
J5251_06285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J5251_06290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J5251_06295	COG0542	response to heat
J5251_06305	COG0596	Alpha beta hydrolase
J5251_06320	COG2132	Multicopper oxidase
J5251_06345	COG1793	dna ligase
J5251_06355	COG2197	response regulator
J5251_06360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J5251_06370	COG0589	response to stress
J5251_06400	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J5251_06415	COG0351	phosphomethylpyrimidine kinase
J5251_06445	COG0343	queuine tRNA-ribosyltransferase activity
J5251_06480	COG3842	ATPase activity
J5251_06505	COG1960	acyl-CoA dehydrogenase activity
J5251_06520	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
J5251_06530	COG1414	Transcriptional regulator
J5251_06540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J5251_06540	COG0574	Belongs to the PEP-utilizing enzyme family
J5251_06545	COG3848	Pyruvate phosphate dikinase
J5251_06545	COG0574	Belongs to the PEP-utilizing enzyme family
J5251_06550	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_06575	COG0477	Major facilitator Superfamily
J5251_06580	COG1234	tRNA 3'-trailer cleavage
J5251_06620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5251_06625	COG0564	pseudouridine synthase activity
J5251_06640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J5251_06645	COG1201	RNA secondary structure unwinding
J5251_06665	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J5251_06700	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
J5251_06710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5251_06715	COG2062	phosphohistidine phosphatase, SixA
J5251_06740	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
J5251_06745	COG3848	Pyruvate phosphate dikinase
J5251_06745	COG0574	Belongs to the PEP-utilizing enzyme family
J5251_06755	COG1959	2 iron, 2 sulfur cluster binding
J5251_06765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J5251_06780	COG1505	serine-type exopeptidase activity
J5251_06795	COG0737	Belongs to the 5'-nucleotidase family
J5251_06795	COG1525	nuclease
J5251_06795	COG4085	toxin activity
J5251_06805	COG0604	alcohol dehydrogenase
J5251_06805	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_06805	COG3321	synthase
J5251_06810	COG1966	Carbon starvation protein
J5251_06855	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J5251_06875	COG0588	phosphoglycerate mutase activity
J5251_06885	COG5002	protein histidine kinase activity
J5251_06905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J5251_06910	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J5251_06915	COG0215	cysteine-tRNA ligase activity
J5251_06920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J5251_06945	COG1295	ribonuclease BN
J5251_06970	COG0366	Alpha amylase catalytic
J5251_06975	COG0366	Alpha amylase catalytic
J5251_06980	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J5251_07085	COG0277	FAD linked oxidase domain protein
J5251_07090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J5251_07100	COG3842	ATPase activity
J5251_07110	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
J5251_07155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5251_07160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5251_07165	COG1414	Transcriptional regulator
J5251_07170	COG1082	Xylose isomerase domain protein TIM barrel
J5251_07170	COG3185	4-Hydroxyphenylpyruvate dioxygenase
J5251_07175	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J5251_07180	COG0477	Major facilitator Superfamily
J5251_07210	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J5251_07230	COG2314	TM2 domain
J5251_07235	COG0459	protein refolding
J5251_07245	COG0328	RNA-DNA hybrid ribonuclease activity
J5251_07255	COG2205	protein histidine kinase activity
J5251_07260	COG0745	RESPONSE REGULATOR receiver
J5251_07265	COG2226	methyltransferase
J5251_07270	COG1061	Type III restriction enzyme res subunit
J5251_07285	COG1278	Cold shock
J5251_07295	COG2814	Major facilitator Superfamily
J5251_07310	COG0739	heme binding
J5251_07345	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J5251_07375	COG1132	(ABC) transporter
J5251_07400	COG0668	transmembrane transport
J5251_07405	COG0045	succinate-CoA ligase (ADP-forming) activity
J5251_07415	COG1063	alcohol dehydrogenase
J5251_07420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J5251_07435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J5251_07445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J5251_07460	COG1414	Transcriptional regulator
J5251_07495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J5251_07520	COG1760	l-serine dehydratase
J5251_07565	COG1063	alcohol dehydrogenase
J5251_07575	COG0028	Belongs to the TPP enzyme family
J5251_07585	COG2186	Transcriptional regulator
J5251_07590	COG1653	transport
J5251_07595	COG1175	transmembrane transport
J5251_07600	COG0395	ABC-type sugar transport system, permease component
J5251_07605	COG4948	Mandelate Racemase Muconate Lactonizing
J5251_07610	COG0800	Aldolase
J5251_07615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J5251_07625	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J5251_07630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J5251_07635	COG1063	alcohol dehydrogenase
J5251_07645	COG1196	nuclear chromosome segregation
J5251_07645	COG0739	heme binding
J5251_07645	COG0741	lytic transglycosylase activity
J5251_07655	COG0431	NADPH-dependent FMN reductase
J5251_07680	COG0583	DNA-binding transcription factor activity
J5251_07685	COG0477	Major facilitator Superfamily
J5251_07705	COG1473	amidohydrolase
J5251_07710	COG3012	SEC-C Motif Domain Protein
J5251_07715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J5251_07720	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
J5251_07740	COG3486	L-lysine 6-monooxygenase (NADPH) activity
J5251_07745	COG0076	glutamate decarboxylase activity
J5251_07760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5251_07810	COG1329	Transcriptional regulator
J5251_07815	COG1309	transcriptional regulator
J5251_07830	COG1278	Cold shock
J5251_07895	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_07900	COG1278	Cold shock
J5251_07905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J5251_07940	COG0671	phosphoesterase, PA-phosphatase related
J5251_07970	COG2197	response regulator
J5251_07975	COG4585	Histidine kinase
J5251_08000	COG0484	heat shock protein binding
J5251_08010	COG0789	Transcriptional regulator
J5251_08040	COG2814	Major facilitator Superfamily
J5251_08045	COG0791	NLP P60 protein
J5251_08045	COG1388	LysM domain
J5251_08055	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J5251_08065	COG0156	8-amino-7-oxononanoate synthase activity
J5251_08070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J5251_08075	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J5251_08080	COG2188	Transcriptional regulator
J5251_08090	COG2066	Belongs to the glutaminase family
J5251_08090	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
J5251_08095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J5251_08110	COG0697	spore germination
J5251_08115	COG1090	epimerase
J5251_08120	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
J5251_08150	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
J5251_08155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5251_08160	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5251_08165	COG1120	ATPase activity
J5251_08170	COG1902	pentaerythritol trinitrate reductase activity
J5251_08205	COG0477	Major facilitator Superfamily
J5251_08235	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
J5251_08240	COG0142	geranyltranstransferase activity
J5251_08250	COG1233	COG1233 Phytoene dehydrogenase and related
J5251_08270	COG0702	epimerase
J5251_08280	COG0415	Belongs to the DNA photolyase family
J5251_08295	COG0783	Belongs to the Dps family
J5251_08305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J5251_08330	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J5251_08330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J5251_08335	COG2329	Antibiotic biosynthesis monooxygenase
J5251_08345	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
J5251_08355	COG0789	Transcriptional regulator
J5251_08365	COG1064	alcohol dehydrogenase
J5251_08420	COG0179	Fumarylacetoacetate (FAA) hydrolase
J5251_08425	COG1802	Transcriptional regulator
J5251_08430	COG1953	Uracil, thiamine, allantoin
J5251_08440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J5251_08470	COG3639	organic phosphonate transmembrane transporter activity
J5251_08475	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
J5251_08480	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
J5251_08485	COG0477	Major facilitator Superfamily
J5251_08495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J5251_08505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5251_08510	COG0601	transmembrane transport
J5251_08515	COG0747	negative chemotaxis
J5251_08520	COG0824	Thioesterase
J5251_08520	COG1250	3-hydroxyacyl-CoA dehydrogenase
J5251_08525	COG1250	3-hydroxyacyl-CoA dehydrogenase
J5251_08530	COG3246	L-lysine catabolic process to acetate
J5251_08540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J5251_08545	COG2072	flavoprotein involved in K transport
J5251_08555	COG0657	acetylesterase activity
J5251_08560	COG0657	acetylesterase activity
J5251_08570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J5251_08585	COG3842	ATPase activity
J5251_08590	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
J5251_08595	COG1176	ABC-type spermidine putrescine transport system, permease component I
J5251_08600	COG1177	transmembrane transport
J5251_08620	COG1595	DNA-templated transcription, initiation
J5251_08655	COG0328	RNA-DNA hybrid ribonuclease activity
J5251_08735	COG0179	Fumarylacetoacetate (FAA) hydrolase
J5251_08760	COG1063	alcohol dehydrogenase
J5251_08770	COG0477	Major facilitator Superfamily
J5251_08780	COG1574	metal-dependent hydrolase with the TIM-barrel fold
J5251_08785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J5251_08795	COG2186	Transcriptional regulator
J5251_08800	COG0747	negative chemotaxis
J5251_08810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5251_08830	COG2186	Transcriptional regulator
J5251_08835	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_08840	COG1012	belongs to the aldehyde dehydrogenase family
J5251_08845	COG1802	Transcriptional regulator
J5251_08850	COG0473	3-isopropylmalate dehydrogenase activity
J5251_08855	COG0583	DNA-binding transcription factor activity
J5251_08865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J5251_08880	COG0436	Aminotransferase
J5251_08885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J5251_08890	COG2364	Membrane
J5251_08900	COG1250	3-hydroxyacyl-CoA dehydrogenase
J5251_08910	COG1960	acyl-CoA dehydrogenase activity
J5251_08925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
J5251_08935	COG0833	amino acid
J5251_08940	COG2124	cytochrome p450
J5251_08965	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J5251_08970	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J5251_08985	COG1012	belongs to the aldehyde dehydrogenase family
J5251_08995	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J5251_09040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5251_09045	COG0778	Nitroreductase
J5251_09045	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
J5251_09055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5251_09070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J5251_09110	COG1454	alcohol dehydrogenase
J5251_09145	COG4977	sequence-specific DNA binding
J5251_09145	COG1917	Cupin 2, conserved barrel domain protein
J5251_09150	COG0583	DNA-binding transcription factor activity
J5251_09155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5251_09165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5251_09175	COG1234	tRNA 3'-trailer cleavage
J5251_09185	COG2205	protein histidine kinase activity
J5251_09190	COG0745	RESPONSE REGULATOR receiver
J5251_09205	COG0574	Belongs to the PEP-utilizing enzyme family
J5251_09205	COG3848	Pyruvate phosphate dikinase
J5251_09260	COG0515	serine threonine protein kinase
J5251_09280	COG1595	DNA-templated transcription, initiation
J5251_09290	COG0028	Belongs to the TPP enzyme family
J5251_09295	COG1802	Transcriptional regulator
J5251_09310	COG3608	succinylglutamate desuccinylase aspartoacylase
J5251_09320	COG0765	amino acid transport
J5251_09375	COG0640	Transcriptional regulator
J5251_09390	COG1595	DNA-templated transcription, initiation
J5251_09425	COG0488	(ABC) transporter
J5251_09440	COG1522	sequence-specific DNA binding
J5251_09450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
J5251_09460	COG2186	Transcriptional regulator
J5251_09465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J5251_09470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5251_09485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5251_09520	COG0028	Belongs to the TPP enzyme family
J5251_09525	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
J5251_09545	COG3842	ATPase activity
J5251_09580	COG0546	phosphoglycolate phosphatase activity
J5251_09605	COG2217	Heavy metal translocating P-type atpase
J5251_09620	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J5251_09635	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
J5251_09635	COG5479	isomerase activity
J5251_09660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J5251_09675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J5251_09685	COG2957	Belongs to the agmatine deiminase family
J5251_09690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J5251_09700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5251_09715	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
J5251_09725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J5251_09740	COG3842	ATPase activity
J5251_09745	COG1176	ABC-type spermidine putrescine transport system, permease component I
J5251_09750	COG1177	transmembrane transport
J5251_09770	COG5416	Lipopolysaccharide assembly protein A domain
J5251_09780	COG3173	Aminoglycoside phosphotransferase
J5251_09815	COG0406	alpha-ribazole phosphatase activity
J5251_09840	COG0589	response to stress
J5251_09865	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
J5251_09885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5251_09895	COG0747	negative chemotaxis
J5251_09900	COG3971	2-oxopent-4-enoate hydratase activity
J5251_09910	COG0438	transferase activity, transferring glycosyl groups
J5251_09910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J5251_09955	COG0477	Major facilitator Superfamily
J5251_09960	COG0138	bifunctional purine biosynthesis protein purh
J5251_09970	COG2838	Isocitrate dehydrogenase
J5251_10005	COG0385	Bile acid
J5251_10020	COG0395	ABC-type sugar transport system, permease component
J5251_10025	COG1175	transmembrane transport
J5251_10030	COG1653	transport
J5251_10045	COG2226	methyltransferase
J5251_10070	COG0492	ferredoxin-NADP+ reductase activity
J5251_10075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J5251_10080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J5251_10085	COG4585	Histidine kinase
J5251_10090	COG2197	response regulator
J5251_10100	COG0477	Major facilitator Superfamily
J5251_10125	COG0583	DNA-binding transcription factor activity
J5251_10160	COG0180	Tryptophanyl-tRNA synthetase
J5251_10180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J5251_10195	COG2009	succinate dehydrogenase
J5251_10205	COG1473	amidohydrolase
J5251_10205	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
J5251_10210	COG1744	ABC transporter substrate-binding protein PnrA-like
J5251_10215	COG3845	ABC transporter
J5251_10220	COG4603	Belongs to the binding-protein-dependent transport system permease family
J5251_10225	COG1079	Belongs to the binding-protein-dependent transport system permease family
J5251_10240	COG0586	Pfam SNARE associated Golgi protein
J5251_10245	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
J5251_10250	COG3956	TIGRFAM MazG family protein
J5251_10255	COG0148	phosphopyruvate hydratase activity
J5251_10280	COG1252	NADH dehydrogenase
J5251_10330	COG0559	Belongs to the binding-protein-dependent transport system permease family
J5251_10335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J5251_10345	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
J5251_10355	COG2017	converts alpha-aldose to the beta-anomer
J5251_10365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J5251_10375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J5251_10385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J5251_10395	COG1331	Highly conserved protein containing a thioredoxin domain
J5251_10405	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J5251_10410	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
J5251_10425	COG2197	response regulator
J5251_10460	COG0114	fumarate hydratase activity
J5251_10465	COG0288	reversible hydration of carbon dioxide
J5251_10475	COG1494	fructose-1,6-bisphosphatase
J5251_10485	COG1482	cell wall glycoprotein biosynthetic process
J5251_10500	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
J5251_10545	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J5251_10550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J5251_10570	COG1022	Amp-dependent synthetase and ligase
J5251_10600	COG0714	Associated with various cellular activities
J5251_10605	COG0084	hydrolase, TatD family'
J5251_10610	COG3583	domain protein
J5251_10615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J5251_10620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J5251_10625	COG0488	(ABC) transporter
J5251_10635	COG2226	methyltransferase
J5251_10660	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
J5251_10685	COG0659	secondary active sulfate transmembrane transporter activity
J5251_10690	COG0542	response to heat
J5251_10720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5251_10750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J5251_10755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J5251_10790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J5251_10795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J5251_10800	COG0251	oxidation-reduction process
J5251_10805	COG0477	Major facilitator Superfamily
J5251_10820	COG0028	Belongs to the TPP enzyme family
J5251_10825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J5251_10830	COG0569	domain protein
J5251_10835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J5251_10840	COG3559	Exporter of polyketide antibiotics
J5251_10845	COG1131	(ABC) transporter
J5251_10855	COG2197	response regulator
J5251_10860	COG0596	Alpha beta hydrolase
J5251_10860	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5251_10870	COG1012	belongs to the aldehyde dehydrogenase family
J5251_10890	COG1802	Transcriptional regulator
J5251_10900	COG3938	Belongs to the proline racemase family
J5251_10910	COG1115	amino acid carrier protein
J5251_10945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J5251_10960	COG1063	alcohol dehydrogenase
J5251_10980	COG4221	oxidoreductase activity
J5251_10990	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
J5251_11005	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
J5251_11040	COG1953	Uracil, thiamine, allantoin
J5251_11090	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_11125	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
J5251_11135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J5251_11140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J5251_11145	COG3206	protein involved in exopolysaccharide biosynthesis
J5251_11145	COG0489	protein tyrosine kinase activity
J5251_11150	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J5251_11155	COG0193	aminoacyl-tRNA hydrolase activity
J5251_11165	COG0822	iron-sulfur transferase activity
J5251_11190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5251_11195	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
J5251_11200	COG0297	glycogen (starch) synthase activity
J5251_11205	COG0463	Glycosyl transferase, family 2
J5251_11235	COG2755	lipolytic protein G-D-S-L family
J5251_11265	COG2271	Major facilitator Superfamily
J5251_11280	COG5002	protein histidine kinase activity
J5251_11320	COG5002	protein histidine kinase activity
J5251_11325	COG1846	Transcriptional regulator
J5251_11355	COG2354	Protein conserved in bacteria
J5251_11360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J5251_11365	COG4214	carbohydrate transport
J5251_11375	COG4213	ABC transporter substrate-binding protein
J5251_11380	COG1063	alcohol dehydrogenase
J5251_11425	COG1215	transferase activity, transferring glycosyl groups
J5251_11440	COG2508	Transcriptional regulator
J5251_11450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5251_11470	COG1126	abc transporter atp-binding protein
J5251_11475	COG0765	amino acid transport
J5251_11490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J5251_11495	COG1473	amidohydrolase
J5251_11510	COG0402	S-adenosylhomocysteine deaminase activity
J5251_11515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J5251_11520	COG1126	abc transporter atp-binding protein
J5251_11525	COG0765	amino acid transport
J5251_11535	COG1522	sequence-specific DNA binding
J5251_11545	COG1609	Transcriptional regulator
J5251_11555	COG1178	ABC-type Fe3 transport system permease component
J5251_11560	COG3842	ATPase activity
J5251_11575	COG5002	protein histidine kinase activity
J5251_11585	COG0179	Fumarylacetoacetate (FAA) hydrolase
J5251_11600	COG4948	Mandelate Racemase Muconate Lactonizing
J5251_11605	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
J5251_11615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J5251_11620	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
J5251_11630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J5251_11700	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
J5251_11700	COG3266	domain, Protein
J5251_11700	COG4932	domain protein
J5251_11710	COG1404	Belongs to the peptidase S8 family
J5251_11720	COG5634	Uncharacterized conserved protein (DUF2278)
J5251_11730	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
J5251_11740	COG0515	serine threonine protein kinase
J5251_11740	COG2815	serine threonine protein kinase
J5251_11760	COG0596	Alpha beta hydrolase
J5251_11765	COG1940	carbohydrate kinase activity
J5251_11770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J5251_11780	COG3962	Belongs to the TPP enzyme family
J5251_11790	COG1082	Xylose isomerase domain protein TIM barrel
J5251_11795	COG0673	inositol 2-dehydrogenase activity
J5251_11800	COG1082	Xylose isomerase domain protein TIM barrel
J5251_11810	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_11815	COG0673	inositol 2-dehydrogenase activity
J5251_11825	COG1609	Transcriptional regulator
J5251_11830	COG3718	enzyme involved in inositol metabolism
J5251_11835	COG2188	Transcriptional regulator
J5251_11845	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5251_11855	COG0673	inositol 2-dehydrogenase activity
J5251_11865	COG0673	inositol 2-dehydrogenase activity
J5251_11875	COG0673	inositol 2-dehydrogenase activity
J5251_11885	COG2271	Major facilitator Superfamily
J5251_11890	COG0454	-acetyltransferase
J5251_11910	COG0514	ATP-dependent DNA helicase (RecQ)
J5251_11925	COG1132	(ABC) transporter
J5251_11975	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J5251_12035	COG3548	integral membrane protein
J5251_12070	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
J5251_12095	COG5002	protein histidine kinase activity
J5251_12100	COG0745	RESPONSE REGULATOR receiver
J5251_12110	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J5251_12120	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
J5251_12125	COG5002	protein histidine kinase activity
J5251_12135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J5251_12140	COG2116	formate transmembrane transporter activity
J5251_12175	COG1648	precorrin-2 dehydrogenase activity
J5251_12175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J5251_12180	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J5251_12195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J5251_12220	COG2183	response to ionizing radiation
J5251_12230	COG2814	Major facilitator Superfamily
J5251_12235	COG0477	Major facilitator Superfamily
J5251_12240	COG2261	transglycosylase associated protein
J5251_12245	COG4770	biotin carboxylase activity
J5251_12250	COG0515	serine threonine protein kinase
J5251_12250	COG2815	serine threonine protein kinase
J5251_12260	COG0424	maF-like protein
J5251_12265	COG1823	symporter activity
J5251_12280	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_12290	COG0702	epimerase
J5251_12300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J5251_12330	COG0714	Associated with various cellular activities
J5251_12350	COG0631	protein serine/threonine phosphatase activity
J5251_12370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J5251_12390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J5251_12395	COG0154	amidase activity
J5251_12400	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J5251_12420	COG0438	transferase activity, transferring glycosyl groups
J5251_12450	COG2124	cytochrome p450
J5251_12455	COG1063	alcohol dehydrogenase
J5251_12460	COG0156	8-amino-7-oxononanoate synthase activity
J5251_12475	COG2986	histidine ammonia-lyase
J5251_12490	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J5251_12505	COG1228	amidohydrolase
J5251_12525	COG2873	o-acetylhomoserine
J5251_12530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J5251_12540	COG2755	lipolytic protein G-D-S-L family
J5251_12575	COG0423	glycine-tRNA ligase activity
J5251_12600	COG0358	DNA primase activity
J5251_12620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J5251_12650	COG0052	Belongs to the universal ribosomal protein uS2 family
J5251_12655	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J5251_12660	COG0528	UMP kinase activity
J5251_12665	COG0233	cytoplasmic translational termination
J5251_12680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J5251_12690	COG3279	Response regulator of the LytR AlgR family
J5251_12695	COG3275	phosphorelay sensor kinase activity
J5251_12705	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J5251_12715	COG1522	sequence-specific DNA binding
J5251_12725	COG0022	dehydrogenase e1 component
J5251_12730	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5251_12740	COG1309	transcriptional regulator
J5251_12745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J5251_12755	COG1960	acyl-CoA dehydrogenase activity
J5251_12780	COG0702	epimerase
J5251_12785	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J5251_12790	COG0750	zinc metalloprotease
J5251_12805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J5251_12815	COG0442	prolyl-tRNA aminoacylation
J5251_12835	COG0779	Required for maturation of 30S ribosomal subunits
J5251_12850	COG0481	GTPase activity
J5251_12850	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J5251_12855	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J5251_12865	COG0590	tRNA wobble adenosine to inosine editing
J5251_12870	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J5251_12890	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J5251_12895	COG1185	polyribonucleotide nucleotidyltransferase activity
J5251_12900	COG0612	Peptidase, M16
J5251_12905	COG1115	amino acid carrier protein
J5251_12920	COG3585	molybdate ion transport
J5251_12950	COG0315	cyclic pyranopterin monophosphate synthase activity
J5251_12955	COG0521	Mo-molybdopterin cofactor biosynthetic process
J5251_12955	COG0315	cyclic pyranopterin monophosphate synthase activity
J5251_12965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J5251_12980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5251_12985	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
J5251_12990	COG1674	ftsk spoiiie
J5251_13000	COG1058	Belongs to the CinA family
J5251_13000	COG1546	Belongs to the CinA family
J5251_13005	COG1396	sequence-specific DNA binding
J5251_13020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J5251_13025	COG2137	regulation of response to DNA damage stimulus
J5251_13030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J5251_13035	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J5251_13040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J5251_13045	COG2813	Specifically methylates the guanine in position
J5251_13050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J5251_13060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J5251_13070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J5251_13075	COG0131	Imidazoleglycerol-phosphate dehydratase
J5251_13080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J5251_13085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J5251_13100	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J5251_13105	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J5251_13110	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J5251_13115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J5251_13120	COG2814	Major facilitator Superfamily
J5251_13125	COG0494	nUDIX hydrolase
J5251_13140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J5251_13145	COG0072	phenylalanine-tRNA ligase activity
J5251_13145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5251_13170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J5251_13175	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J5251_13180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J5251_13185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J5251_13190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J5251_13195	COG1438	arginine binding
J5251_13200	COG0137	argininosuccinate synthase activity
J5251_13205	COG0165	Argininosuccinate lyase
J5251_13215	COG2094	Belongs to the DNA glycosylase MPG family
J5251_13220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J5251_13230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J5251_13260	COG0647	UMP catabolic process
J5251_13275	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J5251_13280	COG0497	DNA recombination
J5251_13285	COG0504	CTP synthase activity
J5251_13300	COG1051	belongs to the nudix hydrolase family
J5251_13310	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
J5251_13315	COG2079	MmgE PrpD family protein
J5251_13335	COG3290	protein histidine kinase activity
J5251_13350	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J5251_13355	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J5251_13370	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J5251_13375	COG1160	GTP binding
J5251_13385	COG0509	glycine decarboxylation via glycine cleavage system
J5251_13390	COG1716	ATPase activity
J5251_13415	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
J5251_13445	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
J5251_13450	COG2815	serine threonine protein kinase
J5251_13450	COG0515	serine threonine protein kinase
J5251_13455	COG1388	LysM domain
J5251_13455	COG3942	CHAP domain
J5251_13465	COG0142	geranyltranstransferase activity
J5251_13470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J5251_13480	COG2001	Belongs to the MraZ family
J5251_13485	COG0275	rRNA processing
J5251_13495	COG0768	penicillin binding
J5251_13500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J5251_13510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J5251_13515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J5251_13525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J5251_13530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J5251_13540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J5251_13550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J5251_13555	COG1799	cell septum assembly
J5251_13570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J5251_13580	COG0587	DNA-directed DNA polymerase activity
J5251_13590	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J5251_13595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J5251_13615	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J5251_13625	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J5251_13650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J5251_13655	COG0321	lipoyl(octanoyl) transferase activity
J5251_13665	COG1090	epimerase
J5251_13670	COG0793	Belongs to the peptidase S41A family
J5251_13670	COG4946	Tricorn protease homolog
J5251_13685	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5251_13690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5251_13695	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J5251_13715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J5251_13725	COG0187	DNA topoisomerase II activity
J5251_13740	COG1271	oxidase subunit
J5251_13745	COG1294	oxidase, subunit
J5251_13750	COG4988	ABC transporter
J5251_13770	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J5251_13805	COG0756	dUTP diphosphatase activity
J5251_13830	COG0569	domain protein
J5251_13835	COG0531	amino acid
J5251_13840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J5251_13845	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J5251_13850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J5251_13855	COG3557	Belongs to the UPF0374 family
J5251_13865	COG3663	DNA glycosylase
J5251_13870	COG0137	argininosuccinate synthase activity
J5251_13875	COG0667	Aldo Keto reductase
J5251_13900	COG1024	Enoyl-CoA hydratase
J5251_13900	COG1250	3-hydroxyacyl-CoA dehydrogenase
J5251_13905	COG0183	Belongs to the thiolase family
J5251_13910	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
J5251_13935	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J5251_13950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J5251_14010	COG0242	peptide deformylase activity
J5251_14015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J5251_14025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J5251_14045	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J5251_14045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J5251_14055	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J5251_14060	COG0140	phosphoribosyl-ATP diphosphatase activity
J5251_14065	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J5251_14070	COG0107	imidazoleglycerol-phosphate synthase activity
J5251_14080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J5251_14100	COG0134	indole-3-glycerol-phosphate synthase activity
J5251_14105	COG0133	tryptophan synthase activity
J5251_14110	COG0159	tryptophan synthase activity
J5251_14115	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J5251_14120	COG0067	glutamate synthase
J5251_14120	COG0070	glutamate synthase
J5251_14120	COG0069	glutamate synthase activity
J5251_14130	COG0469	pyruvate kinase activity
J5251_14160	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
J5251_14170	COG3285	dna ligase
J5251_14170	COG1793	dna ligase
J5251_14185	COG0477	Major facilitator Superfamily
J5251_14190	COG1643	Atp-dependent helicase
J5251_14215	COG0009	L-threonylcarbamoyladenylate synthase
J5251_14225	COG0174	glutamine synthetase
J5251_14255	COG2050	protein possibly involved in aromatic compounds catabolism
J5251_14270	COG4552	Acetyltransferase involved in intracellular survival and related
J5251_14275	COG0539	negative regulation of cytoplasmic translation
J5251_14285	COG1739	Uncharacterized protein family UPF0029
J5251_14300	COG0237	dephospho-CoA kinase activity
J5251_14300	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
J5251_14305	COG0477	Major facilitator Superfamily
J5251_14310	COG0556	nucleotide-excision repair
J5251_14320	COG0477	Major facilitator Superfamily
J5251_14340	COG4106	trans-aconitate 2-methyltransferase activity
J5251_14350	COG1725	Transcriptional regulator
J5251_14360	COG0546	phosphoglycolate phosphatase activity
J5251_14370	COG0322	excinuclease ABC activity
J5251_14375	COG1660	Displays ATPase and GTPase activities
J5251_14380	COG0391	Required for morphogenesis under gluconeogenic growth conditions
J5251_14385	COG1481	regulation of sporulation
J5251_14400	COG0126	phosphoglycerate kinase activity
J5251_14405	COG0149	triose-phosphate isomerase activity
J5251_14410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J5251_14420	COG0363	glucosamine-6-phosphate deaminase activity
J5251_14435	COG0166	Belongs to the GPI family
J5251_14440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J5251_14450	COG0109	protoheme IX farnesyltransferase activity
J5251_14455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5251_14470	COG1131	(ABC) transporter
J5251_14495	COG0396	ATPase activity
J5251_14500	COG2151	metal-sulfur cluster biosynthetic enzyme
J5251_14520	COG1122	ATPase activity
J5251_14525	COG1268	BioY protein
J5251_14530	COG0488	(ABC) transporter
J5251_14550	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_14555	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_14565	COG1119	ATPase activity
J5251_14580	COG0254	rRNA binding
J5251_14620	COG1305	Transglutaminase-like
J5251_14625	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
J5251_14635	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
J5251_14640	COG0297	glycogen (starch) synthase activity
J5251_14655	COG0183	Belongs to the thiolase family
J5251_14660	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_14670	COG3844	kynureninase activity
J5251_14675	COG0438	transferase activity, transferring glycosyl groups
J5251_14685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J5251_14695	COG3424	synthase
J5251_14730	COG0366	Alpha amylase catalytic
J5251_14740	COG0028	Belongs to the TPP enzyme family
J5251_14770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J5251_14840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J5251_14860	COG0667	Aldo Keto reductase
J5251_14865	COG1968	undecaprenyl-diphosphatase activity
J5251_14870	COG0215	cysteine-tRNA ligase activity
J5251_14880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J5251_14895	COG1222	aaa ATPase
J5251_14900	COG4122	O-methyltransferase activity
J5251_14910	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
J5251_14915	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
J5251_14920	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
J5251_14925	COG0545	Peptidyl-prolyl cis-trans isomerase
J5251_14935	COG2378	regulation of single-species biofilm formation
J5251_14945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J5251_14950	COG0805	protein transport
J5251_14955	COG4581	dead DEAH box helicase
J5251_14965	COG1216	Glycosyl transferase, family 2
J5251_14990	COG0823	Involved in the tonB-independent uptake of proteins
J5251_14990	COG1506	peptidase
J5251_14990	COG4946	Tricorn protease homolog
J5251_14995	COG0242	peptide deformylase activity
J5251_15005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J5251_15020	COG0477	Major facilitator Superfamily
J5251_15055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J5251_15060	COG1845	cytochrome c oxidase, subunit III
J5251_15065	COG2010	Cytochrome c
J5251_15070	COG0723	plastoquinol--plastocyanin reductase activity
J5251_15075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J5251_15080	COG2188	Transcriptional regulator
J5251_15090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J5251_15095	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J5251_15115	COG0167	dihydroorotate dehydrogenase activity
J5251_15125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J5251_15130	COG1381	Involved in DNA repair and RecF pathway recombination
J5251_15135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J5251_15140	COG3590	peptidase
J5251_15145	COG1316	TRANSCRIPTIONal
J5251_15150	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J5251_15160	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J5251_15180	COG0484	heat shock protein binding
J5251_15185	COG1420	regulation of RNA biosynthetic process
J5251_15205	COG0481	GTPase activity
J5251_15215	COG0268	Binds directly to 16S ribosomal RNA
J5251_15230	COG1555	photosystem II stabilization
J5251_15230	COG1596	polysaccharide export
J5251_15235	COG1307	EDD domain protein, DegV family
J5251_15240	COG0495	leucyl-tRNA aminoacylation
J5251_15245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J5251_15270	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J5251_15280	COG1758	RNA polymerase activity
J5251_15285	COG0194	GDP metabolic process
J5251_15290	COG0194	GDP metabolic process
J5251_15295	COG0284	orotidine-5'-phosphate decarboxylase activity
J5251_15300	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J5251_15305	COG0505	Belongs to the CarA family
J5251_15315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J5251_15320	COG0540	Belongs to the ATCase OTCase family
J5251_15325	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
J5251_15330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J5251_15335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J5251_15340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J5251_15345	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J5251_15350	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J5251_15355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J5251_15365	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J5251_15370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J5251_15385	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J5251_15390	COG1490	D-aminoacyl-tRNA deacylase activity
J5251_15405	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J5251_15415	COG0124	histidyl-tRNA synthetase
J5251_15425	COG1196	nuclear chromosome segregation
J5251_15435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J5251_15445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J5251_15455	COG2255	four-way junction helicase activity
J5251_15460	COG0632	four-way junction helicase activity
J5251_15465	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J5251_15470	COG0217	transcriptional regulatory protein
J5251_15475	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
J5251_15480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J5251_15500	COG0339	signal peptide processing
J5251_15510	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
J5251_15515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J5251_15525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J5251_15530	COG0587	DNA-directed DNA polymerase activity
J5251_15550	COG2135	peptidase activity
J5251_15565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5251_15610	COG0596	Alpha beta hydrolase
J5251_15615	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
J5251_15630	COG0464	growth
J5251_15645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J5251_15715	COG1802	Transcriptional regulator
J5251_15720	COG0179	Fumarylacetoacetate (FAA) hydrolase
J5251_15725	COG0596	Alpha beta hydrolase
J5251_15735	COG1234	tRNA 3'-trailer cleavage
J5251_15750	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J5251_15755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J5251_15760	COG1780	Probably involved in ribonucleotide reductase function
J5251_15765	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
J5251_15770	COG0583	DNA-binding transcription factor activity
J5251_15800	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J5251_15810	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J5251_15815	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J5251_15820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J5251_15825	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J5251_15830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J5251_15835	COG0351	phosphomethylpyrimidine kinase
J5251_15835	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
J5251_15835	COG0352	thiamine-phosphate diphosphorylase activity
J5251_15840	COG1530	ribonuclease E activity
J5251_15850	COG0105	UTP biosynthetic process
J5251_15860	COG0285	dihydrofolate synthase activity
J5251_15865	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J5251_15880	COG0525	valine-tRNA ligase activity
J5251_15885	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J5251_15890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J5251_15895	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J5251_15900	COG0740	serine-type endopeptidase activity
J5251_15905	COG0740	serine-type endopeptidase activity
J5251_15910	COG0544	peptidyl-prolyl cis-trans isomerase activity
J5251_15970	COG1946	Acyl-CoA thioesterase
J5251_15995	COG0438	transferase activity, transferring glycosyl groups
J5251_16000	COG1904	glucuronate isomerase
J5251_16005	COG0246	Mannitol dehydrogenase
J5251_16010	COG4948	Mandelate Racemase Muconate Lactonizing
J5251_16015	COG3265	gluconokinase activity
J5251_16020	COG1609	Transcriptional regulator
J5251_16025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J5251_16050	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
J5251_16055	COG0438	transferase activity, transferring glycosyl groups
J5251_16065	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J5251_16065	COG2755	lipolytic protein G-D-S-L family
J5251_16080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J5251_16085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J5251_16105	COG1134	teichoic acid transport
J5251_16145	COG0242	peptide deformylase activity
J5251_16185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
J5251_16190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J5251_16200	COG1045	serine acetyltransferase
J5251_16205	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
J5251_16235	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
J5251_16250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J5251_16255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J5251_16270	COG4974	Belongs to the 'phage' integrase family
J5251_16285	COG0792	nuclease activity
J5251_16295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J5251_16305	COG0681	Belongs to the peptidase S26 family
J5251_16310	COG0335	large ribosomal subunit rRNA binding
J5251_16315	COG0336	Belongs to the RNA methyltransferase TrmD family
J5251_16320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J5251_16325	COG1837	Belongs to the UPF0109 family
J5251_16330	COG0228	four-way junction DNA binding
J5251_16340	COG2514	catechol 2,3-dioxygenase activity
J5251_16365	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J5251_16380	COG0477	Major facilitator Superfamily
J5251_16385	COG3384	dioxygenase
J5251_16400	COG3025	triphosphatase activity
J5251_16400	COG5607	PFAM CHAD domain containing protein
J5251_16405	COG0519	Catalyzes the synthesis of GMP from XMP
J5251_16405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J5251_16415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J5251_16420	COG0318	PFAM AMP-dependent synthetase and ligase
J5251_16425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5251_16450	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J5251_16455	COG0571	ribonuclease III activity
J5251_16460	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J5251_16470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J5251_16475	COG0436	Aminotransferase
J5251_16490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J5251_16495	COG1461	Dihydroxyacetone kinase
J5251_16500	COG1316	TRANSCRIPTIONal
J5251_16510	COG1181	Belongs to the D-alanine--D-alanine ligase family
J5251_16515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J5251_16525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J5251_16530	COG0066	3-isopropylmalate dehydratase activity
J5251_16535	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J5251_16540	COG1414	Transcriptional regulator
J5251_16555	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J5251_16575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J5251_16590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5251_16600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J5251_16605	COG0473	3-isopropylmalate dehydrogenase activity
J5251_16630	COG1136	(ABC) transporter
J5251_16630	COG0577	efflux transmembrane transporter activity
J5251_16645	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J5251_16650	COG0440	acetolactate synthase activity
J5251_16660	COG0129	dihydroxy-acid dehydratase activity
J5251_16680	COG2133	pyrroloquinoline quinone binding
J5251_16710	COG0475	glutathione-regulated potassium exporter activity
J5251_16750	COG2132	Multicopper oxidase
J5251_16780	COG0574	Belongs to the PEP-utilizing enzyme family
J5251_16780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J5251_16800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5251_16810	COG1937	Protein conserved in bacteria
J5251_16815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J5251_16820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J5251_16835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5251_16835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J5251_16875	COG0747	negative chemotaxis
J5251_16880	COG0601	transmembrane transport
J5251_16885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5251_16900	COG0747	negative chemotaxis
J5251_16905	COG0579	oxidoreductase
J5251_16910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J5251_16925	COG1305	Transglutaminase-like
J5251_16935	COG1104	cysteine desulfurase activity
J5251_16945	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
J5251_16950	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
J5251_16995	COG1113	amino acid transport
J5251_17005	COG0022	dehydrogenase e1 component
J5251_17010	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5251_17020	COG0515	serine threonine protein kinase
J5251_17035	COG1802	Transcriptional regulator
J5251_17065	COG3226	Transcriptional regulator
J5251_17080	COG0477	Major facilitator Superfamily
J5251_17085	COG1414	Transcriptional regulator
J5251_17095	COG0419	ATPase involved in DNA repair
J5251_17100	COG0420	3'-5' exonuclease activity
J5251_17115	COG1028	Short-chain dehydrogenase reductase Sdr
J5251_17130	COG0586	Pfam SNARE associated Golgi protein
J5251_17135	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J5251_17140	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J5251_17145	COG1234	tRNA 3'-trailer cleavage
J5251_17150	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J5251_17160	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
J5251_17165	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
J5251_17170	COG1335	isochorismatase
J5251_17200	COG1902	pentaerythritol trinitrate reductase activity
J5251_17225	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
J5251_17245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J5251_17250	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J5251_17255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J5251_17260	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J5251_17265	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J5251_17270	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J5251_17275	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J5251_17280	COG0356	it plays a direct role in the translocation of protons across the membrane
J5251_17300	COG1086	Polysaccharide biosynthesis protein
J5251_17310	COG2890	protein-(glutamine-N5) methyltransferase activity
J5251_17315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J5251_17325	COG0083	homoserine kinase activity
J5251_17330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
J5251_17335	COG0460	homoserine dehydrogenase
J5251_17340	COG0019	diaminopimelate decarboxylase activity
J5251_17345	COG0018	arginyl-trna synthetase
J5251_17375	COG1116	anion transmembrane transporter activity
J5251_17375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5251_17390	COG1643	Atp-dependent helicase
J5251_17395	COG0537	adenosine 5'-monophosphoramidase activity
J5251_17400	COG1064	alcohol dehydrogenase
J5251_17420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J5251_17425	COG1121	(ABC) transporter
J5251_17430	COG0803	Belongs to the bacterial solute-binding protein 9 family
J5251_17440	COG1253	flavin adenine dinucleotide binding
J5251_17450	COG0567	Dehydrogenase, E1 component
J5251_17450	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5251_17465	COG1595	DNA-templated transcription, initiation
J5251_17475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J5251_17485	COG0483	inositol monophosphate 1-phosphatase activity
J5251_17490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J5251_17500	COG0803	Belongs to the bacterial solute-binding protein 9 family
J5251_17505	COG1121	(ABC) transporter
J5251_17510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J5251_17520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J5251_17525	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J5251_17550	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J5251_17555	COG1196	nuclear chromosome segregation
J5251_17555	COG0741	lytic transglycosylase activity
J5251_17555	COG0739	heme binding
J5251_17565	COG2884	Cell division ATP-binding protein ftsE
J5251_17570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
J5251_17640	COG0438	transferase activity, transferring glycosyl groups
J5251_17665	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J5251_17670	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
J5251_17695	COG2902	Dehydrogenase
J5251_17730	COG0653	protein targeting
J5251_17735	COG3214	Protein conserved in bacteria
J5251_17740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
J5251_17745	COG1040	competence protein
J5251_17750	COG5401	PFAM Sporulation and spore germination
J5251_17755	COG5000	phosphorelay sensor kinase activity
J5251_17755	COG5002	protein histidine kinase activity
J5251_17780	COG0714	Associated with various cellular activities
J5251_17805	COG0482	sulfurtransferase activity
J5251_17820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J5251_17830	COG0484	heat shock protein binding
J5251_17835	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J5251_17845	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J5251_17850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5251_17860	COG1842	Phage shock protein A
J5251_17870	COG1615	UPF0182 protein
J5251_17875	COG3480	Lon protease (S16) C-terminal proteolytic domain
J5251_17930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J5251_17935	COG2011	ABC-type metal ion transport system permease component
J5251_17940	COG1464	Belongs to the NlpA lipoprotein family
J5251_17950	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J5251_17955	COG0113	porphobilinogen synthase activity
J5251_17965	COG0181	hydroxymethylbilane synthase activity
J5251_17970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J5251_17975	COG3253	May function as heme-dependent peroxidase
J5251_17980	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
J5251_17985	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J5251_17990	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J5251_18015	COG2154	pterin-4-alpha-carbinolamine dehydratase
J5251_18020	COG2022	thiamine diphosphate biosynthetic process
J5251_18030	COG2022	thiamine diphosphate biosynthetic process
J5251_18030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5251_18035	COG0352	thiamine-phosphate diphosphorylase activity
J5251_18050	COG0513	Belongs to the DEAD box helicase family
J5251_18065	COG0613	PHP domain protein
J5251_18070	COG0006	proline dipeptidase activity
J5251_18080	COG2239	Acts as a magnesium transporter
J5251_18095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J5251_18105	COG1595	DNA-templated transcription, initiation
J5251_18110	COG4122	O-methyltransferase activity
J5251_18115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J5251_18135	COG1611	Belongs to the LOG family
J5251_18140	COG1126	abc transporter atp-binding protein
J5251_18145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5251_18150	COG0765	amino acid transport
J5251_18155	COG0765	amino acid transport
J5251_18160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J5251_18165	COG2171	N-acyltransferase activity
J5251_18180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J5251_18215	COG1217	gtp-binding protein TYPA
J5251_18220	COG4172	Belongs to the ABC transporter superfamily
J5251_18225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5251_18230	COG0601	transmembrane transport
J5251_18235	COG4166	transmembrane transport
J5251_18275	COG0012	GTP binding
J5251_18280	COG1322	Protein conserved in bacteria
J5251_18285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J5251_18295	COG1570	exodeoxyribonuclease VII activity
J5251_18300	COG1722	exodeoxyribonuclease VII activity
J5251_18305	COG2326	polyphosphate kinase activity
J5251_18310	COG0436	Aminotransferase
J5251_18330	COG0517	IMP dehydrogenase activity
J5251_18330	COG1125	glycine betaine transport
J5251_18335	COG1051	belongs to the nudix hydrolase family
J5251_18350	COG2205	protein histidine kinase activity
J5251_18355	COG0745	RESPONSE REGULATOR receiver
J5251_18375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J5251_18380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J5251_18400	COG0519	Catalyzes the synthesis of GMP from XMP
J5251_18400	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J5251_18415	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5251_18415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J5251_18420	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
J5251_18425	COG0516	GMP reductase activity
J5251_18435	COG0459	protein refolding
J5251_18440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J5251_18445	COG4607	ABC-type enterochelin transport system periplasmic component
J5251_18450	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5251_18455	COG4605	iron ion homeostasis
J5251_18460	COG4604	ABC transporter, ATP-binding protein
J5251_18475	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J5251_18490	COG1472	Belongs to the glycosyl hydrolase 3 family
J5251_18495	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
J5251_18500	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J5251_18550	COG0802	atpase or kinase
J5251_18555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J5251_18565	COG1486	melibiose metabolic process
J5251_18570	COG2072	flavoprotein involved in K transport
J5251_18595	COG2409	Drug exporters of the RND superfamily
J5251_18615	COG0667	Aldo Keto reductase
J5251_18665	COG1649	PFAM Uncharacterised BCR, COG1649
J5251_18680	COG0736	holo-[acyl-carrier-protein] synthase activity
J5251_18690	COG1072	(Pantothenic acid kinase))
J5251_18700	COG1970	mechanosensitive ion channel activity
J5251_18705	COG1301	dicarboxylic acid transport
J5251_18715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J5251_18720	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J5251_18725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J5251_18735	COG0246	Mannitol dehydrogenase
J5251_18740	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5251_18740	COG2213	PTS system mannitol-specific
J5251_18805	COG0101	tRNA pseudouridine synthase activity
J5251_18810	COG0203	ribosomal protein L17
J5251_18815	COG0202	RNA polymerase activity
J5251_18820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J5251_18825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J5251_18830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J5251_18835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J5251_18840	COG3191	aminopeptidase activity
J5251_18865	COG0024	Methionine aminopeptidase
J5251_18870	COG0563	adenylate kinase activity
J5251_18880	COG0200	Binds to the 23S rRNA
J5251_18885	COG1841	ribosomal large subunit assembly
J5251_18890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J5251_18895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J5251_18900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J5251_18905	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J5251_18910	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J5251_18915	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J5251_18920	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J5251_18925	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J5251_18930	COG0255	Belongs to the universal ribosomal protein uL29 family
J5251_18935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J5251_18940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J5251_18945	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J5251_18950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J5251_18955	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J5251_18960	COG0089	rRNA binding
J5251_18965	COG0088	Forms part of the polypeptide exit tunnel
J5251_18970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J5251_18975	COG0051	transcription antitermination factor activity, RNA binding
J5251_18980	COG2723	6-phospho-beta-galactosidase activity
J5251_18995	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J5251_19000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J5251_19005	COG0049	tRNA binding
J5251_19010	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J5251_19015	COG2755	lipolytic protein G-D-S-L family
J5251_19015	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J5251_19020	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J5251_19020	COG2755	lipolytic protein G-D-S-L family
J5251_19025	COG1414	Transcriptional regulator
J5251_19030	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
J5251_19040	COG0183	Belongs to the thiolase family
J5251_19045	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J5251_19060	COG3485	protocatechuate 3,4-dioxygenase
J5251_19065	COG3485	protocatechuate 3,4-dioxygenase
J5251_19080	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J5251_19085	COG0085	RNA polymerase activity
J5251_19090	COG0183	Belongs to the thiolase family
J5251_19095	COG0442	prolyl-tRNA aminoacylation
J5251_19100	COG0222	ribosome binding
J5251_19105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J5251_19120	COG0081	regulation of translation
J5251_19125	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J5251_19145	COG0436	Aminotransferase
J5251_19150	COG2197	response regulator
J5251_19170	COG1983	PspC domain protein
J5251_19185	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J5251_19190	COG3485	protocatechuate 3,4-dioxygenase
J5251_19200	COG0745	RESPONSE REGULATOR receiver
J5251_19205	COG0456	acetyltransferase
J5251_19210	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J5251_19215	COG0494	nUDIX hydrolase
J5251_19215	COG0406	alpha-ribazole phosphatase activity
J5251_19220	COG1528	Iron-storage protein
J5251_19225	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J5251_19240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J5251_19255	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J5251_19265	COG2030	dehydratase
J5251_19280	COG0693	protein deglycase activity
J5251_19310	COG1132	(ABC) transporter
J5251_19315	COG0438	transferase activity, transferring glycosyl groups
J5251_19340	COG1902	pentaerythritol trinitrate reductase activity
J5251_19340	COG0446	pyridine nucleotide-disulphide oxidoreductase
J5251_19345	COG2258	MOSC domain
J5251_19350	COG1115	amino acid carrier protein
J5251_19370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5251_19385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J5251_19400	COG1666	GTP binding
J5251_19410	COG0501	Belongs to the peptidase M48B family
J5251_19425	COG2267	carboxylic ester hydrolase activity
J5251_19435	COG0753	catalase activity
J5251_19505	COG1674	ftsk spoiiie
J5251_19535	COG1012	belongs to the aldehyde dehydrogenase family
J5251_19545	COG0733	neurotransmitter:sodium symporter activity
J5251_19560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5251_19565	COG1116	anion transmembrane transporter activity
J5251_19575	COG2895	sulfate adenylyltransferase (ATP) activity
J5251_19585	COG0175	sulfate reduction
J5251_19590	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J5251_19620	COG0142	geranyltranstransferase activity
J5251_19630	COG2226	methyltransferase
J5251_19635	COG1169	isochorismate synthase
J5251_19645	COG0765	amino acid transport
J5251_19660	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
J5251_19670	COG4948	Mandelate Racemase Muconate Lactonizing
J5251_19700	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5251_19705	COG0022	dehydrogenase e1 component
J5251_19720	COG1024	Enoyl-CoA hydratase
J5251_19725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J5251_19730	COG2151	metal-sulfur cluster biosynthetic enzyme
J5251_19735	COG3396	Phenylacetate-CoA oxygenase
J5251_19740	COG3460	Phenylacetate-CoA oxygenase
J5251_19745	COG3396	Phenylacetate-CoA oxygenase
J5251_19775	COG1012	belongs to the aldehyde dehydrogenase family
J5251_19775	COG2030	dehydratase
J5251_19800	COG1250	3-hydroxyacyl-CoA dehydrogenase
J5251_19805	COG1024	Enoyl-CoA hydratase
J5251_19830	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
J5251_19860	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J5251_19870	COG0785	Cytochrome C biogenesis protein
J5251_19875	COG3118	belongs to the thioredoxin family
J5251_19880	COG0406	alpha-ribazole phosphatase activity
J5251_19885	COG2353	YceI-like domain
J5251_19895	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
J5251_19920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J5251_19925	COG2971	BadF BadG BcrA BcrD
J5251_19935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J5251_19940	COG0640	Transcriptional regulator
J5251_19945	COG0123	including yeast histone deacetylase and acetoin utilization protein
J5251_19950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J5251_19955	COG0569	domain protein
J5251_19965	COG0248	Ppx GppA phosphatase
J5251_19970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J5251_19970	COG1754	DNA topoisomerase type I activity
J5251_19980	COG2890	protein-(glutamine-N5) methyltransferase activity
J5251_19990	COG1054	Belongs to the UPF0176 family
J5251_20000	COG1111	helicase
J5251_20000	COG1205	dead DEAH box helicase
J5251_20045	COG0494	nUDIX hydrolase
J5251_20050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J5251_20060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J5251_20065	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J5251_20090	COG0251	oxidation-reduction process
J5251_20100	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J5251_20105	COG1408	metallophosphoesterase
J5251_20125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J5251_20130	COG0151	Belongs to the GarS family
J5251_20155	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J5251_20190	COG2353	YceI-like domain