locus-tag	class	description
N9A08_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N9A08_00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
N9A08_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N9A08_00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
N9A08_00030	COG0187	DNA topoisomerase II activity
N9A08_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N9A08_00075	COG0705	Rhomboid family
N9A08_00085	COG3764	Sortase (surface protein transpeptidase)
N9A08_00100	COG2815	serine threonine protein kinase
N9A08_00100	COG0515	serine threonine protein kinase
N9A08_00105	COG0515	serine threonine protein kinase
N9A08_00110	COG0768	penicillin binding
N9A08_00125	COG1716	ATPase activity
N9A08_00130	COG1716	ATPase activity
N9A08_00155	COG3265	gluconokinase activity
N9A08_00160	COG2186	Transcriptional regulator
N9A08_00165	COG0783	Belongs to the Dps family
N9A08_00190	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N9A08_00210	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
N9A08_00220	COG0789	Transcriptional regulator
N9A08_00240	COG0110	maltose O-acetyltransferase activity
N9A08_00250	COG2267	carboxylic ester hydrolase activity
N9A08_00265	COG1376	ErfK ybiS ycfS ynhG family protein
N9A08_00270	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N9A08_00270	COG2755	lipolytic protein G-D-S-L family
N9A08_00275	COG0702	epimerase
N9A08_00280	COG1793	dna ligase
N9A08_00280	COG3285	dna ligase
N9A08_00295	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_00325	COG0561	phosphatase activity
N9A08_00330	COG0671	phosphoesterase, PA-phosphatase related
N9A08_00335	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
N9A08_00340	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
N9A08_00350	COG1929	Belongs to the glycerate kinase type-1 family
N9A08_00355	COG2233	PERMEase
N9A08_00360	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_00365	COG1012	belongs to the aldehyde dehydrogenase family
N9A08_00375	COG1116	anion transmembrane transporter activity
N9A08_00375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N9A08_00390	COG3104	oligopeptide transport
N9A08_00395	COG0154	amidase activity
N9A08_00400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N9A08_00420	COG1597	lipid kinase activity
N9A08_00425	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N9A08_00430	COG0561	phosphatase activity
N9A08_00440	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N9A08_00445	COG2027	D-alanyl-D-alanine carboxypeptidase
N9A08_00455	COG0037	tRNA processing
N9A08_00465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N9A08_00470	COG0302	gtp cyclohydrolase
N9A08_00480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N9A08_00510	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N9A08_00515	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N9A08_00535	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N9A08_00545	COG2376	Dihydroxyacetone kinase
N9A08_00550	COG1461	Dihydroxyacetone kinase
N9A08_00555	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
N9A08_00555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N9A08_00555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N9A08_00570	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
N9A08_00600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N9A08_00605	COG0306	phosphate transporter
N9A08_00650	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N9A08_00650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N9A08_00655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N9A08_00660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N9A08_00660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N9A08_00675	COG2261	transglycosylase associated protein
N9A08_00685	COG2733	membrane
N9A08_00690	COG0584	glycerophosphoryl diester phosphodiesterase
N9A08_00695	COG3387	PFAM Glycoside hydrolase 15-related
N9A08_00715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N9A08_00720	COG0857	belongs to the CobB CobQ family
N9A08_00720	COG0280	phosphate acetyltransferase
N9A08_00725	COG0531	amino acid
N9A08_00740	COG2252	PERMEase
N9A08_00820	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
N9A08_00835	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N9A08_00855	COG0191	fructose-bisphosphate aldolase activity
N9A08_00875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N9A08_00905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N9A08_00925	COG1832	CoA-binding protein
N9A08_00940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N9A08_00945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N9A08_00955	COG1116	anion transmembrane transporter activity
N9A08_00970	COG1832	CoA-binding protein
N9A08_00980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N9A08_00985	COG2011	ABC-type metal ion transport system permease component
N9A08_01010	COG2315	Protein conserved in bacteria
N9A08_01035	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N9A08_01040	COG0047	phosphoribosylformylglycinamidine synthase activity
N9A08_01050	COG1126	abc transporter atp-binding protein
N9A08_01055	COG0765	amino acid transport
N9A08_01060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N9A08_01090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N9A08_01095	COG1846	Transcriptional regulator
N9A08_01115	COG1131	(ABC) transporter
N9A08_01125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N9A08_01180	COG3548	integral membrane protein
N9A08_01195	COG1136	(ABC) transporter
N9A08_01205	COG2197	response regulator
N9A08_01210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N9A08_01220	COG1309	transcriptional regulator
N9A08_01235	COG0318	PFAM AMP-dependent synthetase and ligase
N9A08_01240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N9A08_01245	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
N9A08_01250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N9A08_01250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N9A08_01260	COG0640	Transcriptional regulator
N9A08_01265	COG0798	PFAM Bile acid sodium symporter
N9A08_01270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N9A08_01365	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N9A08_01375	COG1126	abc transporter atp-binding protein
N9A08_01380	COG0765	amino acid transport
N9A08_01395	COG0745	RESPONSE REGULATOR receiver
N9A08_01400	COG2205	protein histidine kinase activity
N9A08_01410	COG1063	alcohol dehydrogenase
N9A08_01465	COG0028	Belongs to the TPP enzyme family
N9A08_01505	COG0531	amino acid
N9A08_01510	COG0477	Major facilitator Superfamily
N9A08_01535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N9A08_01545	COG2764	glyoxalase bleomycin resistance protein dioxygenase
N9A08_01570	COG2200	EAL domain
N9A08_01590	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_01590	COG3321	synthase
N9A08_01590	COG0604	alcohol dehydrogenase
N9A08_01595	COG1063	alcohol dehydrogenase
N9A08_01655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N9A08_01660	COG0657	acetylesterase activity
N9A08_01665	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
N9A08_01670	COG1940	carbohydrate kinase activity
N9A08_01675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N9A08_01680	COG4608	Belongs to the ABC transporter superfamily
N9A08_01685	COG0444	Belongs to the ABC transporter superfamily
N9A08_01695	COG0747	negative chemotaxis
N9A08_01705	COG0363	glucosamine-6-phosphate deaminase activity
N9A08_01710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N9A08_01740	COG1414	Transcriptional regulator
N9A08_01755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N9A08_01765	COG0445	tRNA wobble uridine modification
N9A08_01795	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N9A08_01805	COG1396	sequence-specific DNA binding
N9A08_01815	COG0024	Methionine aminopeptidase
N9A08_01820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N9A08_01835	COG1404	Belongs to the peptidase S8 family
N9A08_01835	COG4412	M6 family metalloprotease domain protein
N9A08_01840	COG0351	phosphomethylpyrimidine kinase
N9A08_01860	COG0343	queuine tRNA-ribosyltransferase activity
N9A08_01925	COG3486	L-lysine 6-monooxygenase (NADPH) activity
N9A08_01950	COG0564	pseudouridine synthase activity
N9A08_01960	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N9A08_01965	COG1201	RNA secondary structure unwinding
N9A08_01975	COG4608	Belongs to the ABC transporter superfamily
N9A08_01980	COG0444	Belongs to the ABC transporter superfamily
N9A08_01985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N9A08_01995	COG4166	transmembrane transport
N9A08_02000	COG1609	Transcriptional regulator
N9A08_02010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N9A08_02020	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N9A08_02030	COG2354	Protein conserved in bacteria
N9A08_02035	COG0697	spore germination
N9A08_02040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N9A08_02060	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N9A08_02070	COG2062	phosphohistidine phosphatase, SixA
N9A08_02085	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
N9A08_02095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N9A08_02100	COG0514	ATP-dependent DNA helicase (RecQ)
N9A08_02110	COG1024	Enoyl-CoA hydratase
N9A08_02120	COG0667	Aldo Keto reductase
N9A08_02125	COG2239	Acts as a magnesium transporter
N9A08_02135	COG1505	serine-type exopeptidase activity
N9A08_02160	COG2860	membrane
N9A08_02175	COG0352	thiamine-phosphate diphosphorylase activity
N9A08_02175	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
N9A08_02175	COG0351	phosphomethylpyrimidine kinase
N9A08_02180	COG0352	thiamine-phosphate diphosphorylase activity
N9A08_02185	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
N9A08_02205	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
N9A08_02210	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
N9A08_02215	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
N9A08_02265	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N9A08_02280	COG1228	amidohydrolase
N9A08_02285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N9A08_02305	COG0737	Belongs to the 5'-nucleotidase family
N9A08_02325	COG1966	Carbon starvation protein
N9A08_02350	COG0656	L-ascorbic acid biosynthetic process
N9A08_02360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N9A08_02365	COG1256	bacterial-type flagellum assembly
N9A08_02365	COG4786	Flagellar basal body rod
N9A08_02380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N9A08_02390	COG1516	flagellar protein fliS
N9A08_02400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N9A08_02415	COG1677	Flagellar hook-basal body complex protein FliE
N9A08_02420	COG1766	The M ring may be actively involved in energy transduction
N9A08_02425	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N9A08_02435	COG1157	protein secretion by the type III secretion system
N9A08_02445	COG0791	NLP P60 protein
N9A08_02445	COG3883	PFAM NLP P60 protein
N9A08_02470	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N9A08_02475	COG1360	Flagellar Motor Protein
N9A08_02485	COG1776	CheC inhibitor of MCP methylation
N9A08_02485	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N9A08_02495	COG1338	Plays a role in the flagellum-specific transport system
N9A08_02515	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N9A08_02525	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
N9A08_02555	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N9A08_02560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N9A08_02580	COG0588	phosphoglycerate mutase activity
N9A08_02590	COG5002	protein histidine kinase activity
N9A08_02595	COG0745	RESPONSE REGULATOR receiver
N9A08_02610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N9A08_02615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N9A08_02620	COG0215	cysteine-tRNA ligase activity
N9A08_02625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N9A08_02640	COG0366	Alpha amylase catalytic
N9A08_02645	COG0366	Alpha amylase catalytic
N9A08_02650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N9A08_02675	COG0277	FAD linked oxidase domain protein
N9A08_02680	COG0366	Alpha amylase catalytic
N9A08_02695	COG3842	ATPase activity
N9A08_02700	COG1877	trehalose-phosphatase activity
N9A08_02705	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
N9A08_02725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N9A08_02730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N9A08_02745	COG1335	isochorismatase
N9A08_02820	COG1053	succinate dehydrogenase
N9A08_02825	COG1802	Transcriptional regulator
N9A08_02840	COG1609	Transcriptional regulator
N9A08_02845	COG0366	Alpha amylase catalytic
N9A08_02855	COG1175	transmembrane transport
N9A08_02860	COG3833	ABC-type maltose transport systems, permease component
N9A08_02865	COG0667	Aldo Keto reductase
N9A08_02905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N9A08_02920	COG1278	Cold shock
N9A08_02930	COG0459	protein refolding
N9A08_02940	COG2205	protein histidine kinase activity
N9A08_02945	COG0745	RESPONSE REGULATOR receiver
N9A08_02950	COG2909	trisaccharide binding
N9A08_02950	COG2909	trisaccharide binding
N9A08_02970	COG1278	Cold shock
N9A08_02995	COG1196	nuclear chromosome segregation
N9A08_02995	COG0741	lytic transglycosylase activity
N9A08_02995	COG0739	heme binding
N9A08_03005	COG3103	Sh3 type 3 domain protein
N9A08_03005	COG1388	LysM domain
N9A08_03005	COG0791	NLP P60 protein
N9A08_03015	COG0746	molybdenum cofactor guanylyltransferase activity
N9A08_03025	COG0303	'Molybdopterin
N9A08_03035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N9A08_03040	COG5002	protein histidine kinase activity
N9A08_03045	COG1132	(ABC) transporter
N9A08_03070	COG0483	inositol monophosphate 1-phosphatase activity
N9A08_03080	COG0045	succinate-CoA ligase (ADP-forming) activity
N9A08_03090	COG2814	Major facilitator Superfamily
N9A08_03120	COG0318	PFAM AMP-dependent synthetase and ligase
N9A08_03130	COG1396	sequence-specific DNA binding
N9A08_03150	COG0028	Belongs to the TPP enzyme family
N9A08_03210	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_03220	COG0028	Belongs to the TPP enzyme family
N9A08_03245	COG0252	asparaginase activity
N9A08_03300	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
N9A08_03305	COG0028	Belongs to the TPP enzyme family
N9A08_03310	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N9A08_03315	COG2390	Transcriptional regulator
N9A08_03340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N9A08_03345	COG0730	response to heat
N9A08_03355	COG0730	response to heat
N9A08_03370	COG3265	gluconokinase activity
N9A08_03375	COG2610	gluconate transmembrane transporter activity
N9A08_03380	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_03385	COG1063	alcohol dehydrogenase
N9A08_03420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N9A08_03430	COG0590	tRNA wobble adenosine to inosine editing
N9A08_03445	COG1309	transcriptional regulator
N9A08_03465	COG0640	Transcriptional regulator
N9A08_03475	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
N9A08_03490	COG0673	inositol 2-dehydrogenase activity
N9A08_03495	COG1879	ABC-type sugar transport system periplasmic component
N9A08_03500	COG1129	ABC transporter
N9A08_03505	COG1172	Belongs to the binding-protein-dependent transport system permease family
N9A08_03510	COG1940	carbohydrate kinase activity
N9A08_03515	COG1914	H( )-stimulated, divalent metal cation uptake system
N9A08_03520	COG4336	lyase activity
N9A08_03545	COG1126	abc transporter atp-binding protein
N9A08_03555	COG4770	biotin carboxylase activity
N9A08_03560	COG1984	allophanate hydrolase subunit 2
N9A08_03565	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N9A08_03570	COG1609	Transcriptional regulator
N9A08_03595	COG1473	amidohydrolase
N9A08_03600	COG0154	amidase activity
N9A08_03620	COG4213	ABC transporter substrate-binding protein
N9A08_03625	COG1129	ABC transporter
N9A08_03630	COG4214	carbohydrate transport
N9A08_03635	COG0583	DNA-binding transcription factor activity
N9A08_03640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N9A08_03655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N9A08_03660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N9A08_03720	COG1802	Transcriptional regulator
N9A08_03735	COG2235	arginine
N9A08_03750	COG3842	ATPase activity
N9A08_03765	COG1609	Transcriptional regulator
N9A08_03775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N9A08_03780	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N9A08_03785	COG1120	ATPase activity
N9A08_03820	COG0154	amidase activity
N9A08_03825	COG2957	Belongs to the agmatine deiminase family
N9A08_03835	COG0251	oxidation-reduction process
N9A08_03855	COG0697	spore germination
N9A08_03860	COG0737	Belongs to the 5'-nucleotidase family
N9A08_03885	COG2115	Belongs to the xylose isomerase family
N9A08_03890	COG1070	Carbohydrate kinase
N9A08_03895	COG1175	transmembrane transport
N9A08_03935	COG3458	cephalosporin-C deacetylase activity
N9A08_03940	COG1472	Belongs to the glycosyl hydrolase 3 family
N9A08_03950	COG1175	transmembrane transport
N9A08_03955	COG1653	transport
N9A08_03965	COG2814	Major facilitator Superfamily
N9A08_03990	COG0477	Major facilitator Superfamily
N9A08_04000	COG0583	DNA-binding transcription factor activity
N9A08_04010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N9A08_04015	COG0154	amidase activity
N9A08_04020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N9A08_04030	COG0667	Aldo Keto reductase
N9A08_04040	COG0363	glucosamine-6-phosphate deaminase activity
N9A08_04050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N9A08_04055	COG0165	Argininosuccinate lyase
N9A08_04060	COG4149	molybdate abc transporter
N9A08_04065	COG3842	ATPase activity
N9A08_04075	COG1940	carbohydrate kinase activity
N9A08_04080	COG0277	FAD linked oxidase domain protein
N9A08_04085	COG2197	response regulator
N9A08_04095	COG2188	Transcriptional regulator
N9A08_04100	COG1620	l-lactate permease
N9A08_04105	COG0247	lactate metabolic process
N9A08_04110	COG1139	Iron-sulfur cluster binding protein
N9A08_04115	COG1556	Lactate utilization protein
N9A08_04120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N9A08_04130	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N9A08_04145	COG3971	2-oxopent-4-enoate hydratase activity
N9A08_04155	COG1620	l-lactate permease
N9A08_04165	COG3619	membrane
N9A08_04170	COG0405	Gamma-glutamyltransferase
N9A08_04180	COG0039	L-malate dehydrogenase activity
N9A08_04185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N9A08_04200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N9A08_04230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N9A08_04235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N9A08_04250	COG3842	ATPase activity
N9A08_04255	COG1176	ABC-type spermidine putrescine transport system, permease component I
N9A08_04260	COG1177	transmembrane transport
N9A08_04275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N9A08_04290	COG1278	Cold shock
N9A08_04295	COG2066	Belongs to the glutaminase family
N9A08_04295	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
N9A08_04300	COG1278	Cold shock
N9A08_04325	COG0515	serine threonine protein kinase
N9A08_04325	COG2815	serine threonine protein kinase
N9A08_04330	COG3012	SEC-C Motif Domain Protein
N9A08_04335	COG1063	alcohol dehydrogenase
N9A08_04340	COG1063	alcohol dehydrogenase
N9A08_04350	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N9A08_04360	COG0753	catalase activity
N9A08_04365	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
N9A08_04430	COG0477	Major facilitator Superfamily
N9A08_04455	COG1136	(ABC) transporter
N9A08_04455	COG4591	ABC-type transport system involved in lipoprotein release permease component
N9A08_04460	COG0577	efflux transmembrane transporter activity
N9A08_04460	COG1136	(ABC) transporter
N9A08_04470	COG4213	ABC transporter substrate-binding protein
N9A08_04475	COG4214	carbohydrate transport
N9A08_04480	COG1129	ABC transporter
N9A08_04485	COG1940	carbohydrate kinase activity
N9A08_04505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N9A08_04510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N9A08_04530	COG2197	response regulator
N9A08_04535	COG4585	Histidine kinase
N9A08_04560	COG0180	Tryptophanyl-tRNA synthetase
N9A08_04575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N9A08_04590	COG2009	succinate dehydrogenase
N9A08_04600	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N9A08_04600	COG1473	amidohydrolase
N9A08_04605	COG1744	ABC transporter substrate-binding protein PnrA-like
N9A08_04610	COG3845	ABC transporter
N9A08_04615	COG4603	Belongs to the binding-protein-dependent transport system permease family
N9A08_04620	COG1079	Belongs to the binding-protein-dependent transport system permease family
N9A08_04640	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N9A08_04645	COG3956	TIGRFAM MazG family protein
N9A08_04650	COG0148	phosphopyruvate hydratase activity
N9A08_04685	COG0683	leucine binding
N9A08_04705	COG0559	Belongs to the binding-protein-dependent transport system permease family
N9A08_04730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N9A08_04735	COG0705	Rhomboid family
N9A08_04740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N9A08_04750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N9A08_04760	COG1331	Highly conserved protein containing a thioredoxin domain
N9A08_04770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N9A08_04780	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N9A08_04810	COG0114	fumarate hydratase activity
N9A08_04825	COG1494	fructose-1,6-bisphosphatase
N9A08_04845	COG1316	TRANSCRIPTIONal
N9A08_04900	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
N9A08_04950	COG0714	Associated with various cellular activities
N9A08_04955	COG0084	hydrolase, TatD family'
N9A08_04975	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N9A08_04980	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N9A08_04985	COG0488	(ABC) transporter
N9A08_05005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N9A08_05010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N9A08_05015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N9A08_05020	COG0193	aminoacyl-tRNA hydrolase activity
N9A08_05060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N9A08_05070	COG0110	maltose O-acetyltransferase activity
N9A08_05075	COG2755	lipolytic protein G-D-S-L family
N9A08_05105	COG0489	protein tyrosine kinase activity
N9A08_05140	COG0822	iron-sulfur transferase activity
N9A08_05150	COG5002	protein histidine kinase activity
N9A08_05155	COG0745	RESPONSE REGULATOR receiver
N9A08_05165	COG1012	belongs to the aldehyde dehydrogenase family
N9A08_05200	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N9A08_05235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N9A08_05240	COG1012	belongs to the aldehyde dehydrogenase family
N9A08_05245	COG1819	glycosyl
N9A08_05255	COG3842	ATPase activity
N9A08_05260	COG1177	transmembrane transport
N9A08_05275	COG3281	Trehalose synthase
N9A08_05295	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N9A08_05320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N9A08_05335	COG0477	Major facilitator Superfamily
N9A08_05340	COG4770	biotin carboxylase activity
N9A08_05350	COG0424	maF-like protein
N9A08_05355	COG1823	symporter activity
N9A08_05370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N9A08_05375	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_05400	COG0714	Associated with various cellular activities
N9A08_05415	COG0631	protein serine/threonine phosphatase activity
N9A08_05450	COG1674	ftsk spoiiie
N9A08_05500	COG4941	Belongs to the sigma-70 factor family
N9A08_05510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N9A08_05515	COG0483	inositol monophosphate 1-phosphatase activity
N9A08_05525	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N9A08_05535	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N9A08_05540	COG0154	amidase activity
N9A08_05545	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N9A08_05570	COG1254	Belongs to the acylphosphatase family
N9A08_05575	COG2986	histidine ammonia-lyase
N9A08_05600	COG2873	o-acetylhomoserine
N9A08_05605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N9A08_05630	COG0423	glycine-tRNA ligase activity
N9A08_05640	COG1309	transcriptional regulator
N9A08_05645	COG1511	domain protein
N9A08_05650	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N9A08_05670	COG0358	DNA primase activity
N9A08_05690	COG0477	Major facilitator Superfamily
N9A08_05700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N9A08_05710	COG0297	glycogen (starch) synthase activity
N9A08_05730	COG0052	Belongs to the universal ribosomal protein uS2 family
N9A08_05735	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N9A08_05740	COG0528	UMP kinase activity
N9A08_05745	COG0233	cytoplasmic translational termination
N9A08_05750	COG0575	Belongs to the CDS family
N9A08_05760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N9A08_05775	COG3275	phosphorelay sensor kinase activity
N9A08_05785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N9A08_05790	COG1522	sequence-specific DNA binding
N9A08_05800	COG0022	dehydrogenase e1 component
N9A08_05805	COG0508	dehydrogenase complex catalyzes the overall conversion of
N9A08_05815	COG1309	transcriptional regulator
N9A08_05820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N9A08_05830	COG1960	acyl-CoA dehydrogenase activity
N9A08_05860	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N9A08_05865	COG0750	zinc metalloprotease
N9A08_05885	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N9A08_05900	COG0442	prolyl-tRNA aminoacylation
N9A08_05920	COG0779	Required for maturation of 30S ribosomal subunits
N9A08_05935	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N9A08_05940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N9A08_05945	COG0436	Aminotransferase
N9A08_05950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N9A08_05975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N9A08_05980	COG1185	polyribonucleotide nucleotidyltransferase activity
N9A08_05985	COG0612	Peptidase, M16
N9A08_06000	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
N9A08_06015	COG0315	cyclic pyranopterin monophosphate synthase activity
N9A08_06020	COG0521	Mo-molybdopterin cofactor biosynthetic process
N9A08_06030	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N9A08_06045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N9A08_06050	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N9A08_06055	COG1674	ftsk spoiiie
N9A08_06065	COG1546	Belongs to the CinA family
N9A08_06065	COG1058	Belongs to the CinA family
N9A08_06070	COG1396	sequence-specific DNA binding
N9A08_06085	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N9A08_06105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N9A08_06110	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N9A08_06115	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N9A08_06120	COG2813	Specifically methylates the guanine in position
N9A08_06125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N9A08_06135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N9A08_06145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N9A08_06150	COG0131	Imidazoleglycerol-phosphate dehydratase
N9A08_06155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N9A08_06165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N9A08_06185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N9A08_06190	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N9A08_06195	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N9A08_06200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N9A08_06205	COG2814	Major facilitator Superfamily
N9A08_06210	COG0494	nUDIX hydrolase
N9A08_06235	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N9A08_06240	COG0072	phenylalanine-tRNA ligase activity
N9A08_06240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N9A08_06255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N9A08_06260	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N9A08_06265	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N9A08_06270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N9A08_06275	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N9A08_06280	COG1438	arginine binding
N9A08_06285	COG0137	argininosuccinate synthase activity
N9A08_06290	COG0165	Argininosuccinate lyase
N9A08_06295	COG0259	pyridoxamine-phosphate oxidase activity
N9A08_06305	COG2094	Belongs to the DNA glycosylase MPG family
N9A08_06310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N9A08_06320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N9A08_06345	COG0647	UMP catabolic process
N9A08_06360	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N9A08_06365	COG0497	DNA recombination
N9A08_06370	COG0504	CTP synthase activity
N9A08_06375	COG0494	nUDIX hydrolase
N9A08_06385	COG1051	belongs to the nudix hydrolase family
N9A08_06400	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N9A08_06405	COG2079	MmgE PrpD family protein
N9A08_06420	COG4565	transcriptional regulatory protein
N9A08_06425	COG3290	protein histidine kinase activity
N9A08_06430	COG1301	dicarboxylic acid transport
N9A08_06450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N9A08_06465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N9A08_06470	COG1160	GTP binding
N9A08_06480	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_06485	COG2072	flavoprotein involved in K transport
N9A08_06510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N9A08_06515	COG1716	ATPase activity
N9A08_06540	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
N9A08_06555	COG1940	carbohydrate kinase activity
N9A08_06575	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
N9A08_06580	COG0515	serine threonine protein kinase
N9A08_06580	COG2815	serine threonine protein kinase
N9A08_06595	COG0142	geranyltranstransferase activity
N9A08_06605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N9A08_06615	COG2001	Belongs to the MraZ family
N9A08_06620	COG0275	rRNA processing
N9A08_06630	COG0768	penicillin binding
N9A08_06645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N9A08_06650	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N9A08_06660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N9A08_06665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N9A08_06670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N9A08_06675	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N9A08_06690	COG1799	cell septum assembly
N9A08_06700	COG3599	regulation of cell shape
N9A08_06705	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N9A08_06715	COG0587	DNA-directed DNA polymerase activity
N9A08_06720	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N9A08_06725	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N9A08_06745	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N9A08_06750	COG0174	glutamine synthetase
N9A08_06755	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N9A08_06760	COG0765	amino acid transport
N9A08_06765	COG1126	abc transporter atp-binding protein
N9A08_06790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N9A08_06795	COG0321	lipoyl(octanoyl) transferase activity
N9A08_06800	COG0515	serine threonine protein kinase
N9A08_06805	COG4946	Tricorn protease homolog
N9A08_06805	COG0793	Belongs to the peptidase S41A family
N9A08_06815	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N9A08_06820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N9A08_06825	COG1764	response to oxidative stress
N9A08_06835	COG0508	dehydrogenase complex catalyzes the overall conversion of
N9A08_06840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N9A08_06845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N9A08_06865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N9A08_06875	COG0187	DNA topoisomerase II activity
N9A08_06880	COG0501	Belongs to the peptidase M48B family
N9A08_06890	COG1271	oxidase subunit
N9A08_06895	COG1294	oxidase, subunit
N9A08_06900	COG4988	ABC transporter
N9A08_06915	COG1937	Protein conserved in bacteria
N9A08_06930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N9A08_06945	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
N9A08_06950	COG1435	thymidine kinase activity
N9A08_06970	COG0756	dUTP diphosphatase activity
N9A08_06995	COG0569	domain protein
N9A08_07000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N9A08_07005	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N9A08_07010	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N9A08_07025	COG0667	Aldo Keto reductase
N9A08_07035	COG1846	Transcriptional regulator
N9A08_07060	COG0667	Aldo Keto reductase
N9A08_07075	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N9A08_07085	COG1024	Enoyl-CoA hydratase
N9A08_07085	COG1250	3-hydroxyacyl-CoA dehydrogenase
N9A08_07090	COG0183	Belongs to the thiolase family
N9A08_07120	COG1252	NADH dehydrogenase
N9A08_07125	COG1595	DNA-templated transcription, initiation
N9A08_07155	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N9A08_07160	COG0183	Belongs to the thiolase family
N9A08_07180	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
N9A08_07200	COG1269	ATP hydrolysis coupled proton transport
N9A08_07220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N9A08_07255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N9A08_07320	COG0242	peptide deformylase activity
N9A08_07325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N9A08_07335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N9A08_07345	COG0488	(ABC) transporter
N9A08_07365	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N9A08_07365	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N9A08_07370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N9A08_07370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N9A08_07375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N9A08_07380	COG0402	S-adenosylhomocysteine deaminase activity
N9A08_07395	COG0140	phosphoribosyl-ATP diphosphatase activity
N9A08_07400	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N9A08_07405	COG0107	imidazoleglycerol-phosphate synthase activity
N9A08_07415	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N9A08_07435	COG0134	indole-3-glycerol-phosphate synthase activity
N9A08_07440	COG0133	tryptophan synthase activity
N9A08_07445	COG0159	tryptophan synthase activity
N9A08_07450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N9A08_07455	COG0070	glutamate synthase
N9A08_07455	COG0069	glutamate synthase activity
N9A08_07455	COG0067	glutamate synthase
N9A08_07465	COG0469	pyruvate kinase activity
N9A08_07490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N9A08_07495	COG0385	Bile acid
N9A08_07520	COG1940	carbohydrate kinase activity
N9A08_07535	COG0415	Belongs to the DNA photolyase family
N9A08_07545	COG1846	Transcriptional regulator
N9A08_07550	COG1132	(ABC) transporter
N9A08_07565	COG0436	Aminotransferase
N9A08_07570	COG2890	protein-(glutamine-N5) methyltransferase activity
N9A08_07575	COG3585	molybdate ion transport
N9A08_07600	COG3173	Aminoglycoside phosphotransferase
N9A08_07610	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N9A08_07620	COG1643	Atp-dependent helicase
N9A08_07650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N9A08_07655	COG0569	domain protein
N9A08_07665	COG1937	Protein conserved in bacteria
N9A08_07675	COG1785	Belongs to the alkaline phosphatase family
N9A08_07680	COG0009	L-threonylcarbamoyladenylate synthase
N9A08_07695	COG2814	Major facilitator Superfamily
N9A08_07700	COG1793	dna ligase
N9A08_07700	COG3285	dna ligase
N9A08_07705	COG0778	Nitroreductase
N9A08_07735	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N9A08_07745	COG2272	Belongs to the type-B carboxylesterase lipase family
N9A08_07750	COG0488	(ABC) transporter
N9A08_07760	COG2272	Belongs to the type-B carboxylesterase lipase family
N9A08_07775	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N9A08_07780	COG1793	dna ligase
N9A08_07790	COG1607	acyl-coa hydrolase
N9A08_07795	COG2807	transmembrane transport
N9A08_07800	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N9A08_07810	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N9A08_07815	COG1082	Xylose isomerase domain protein TIM barrel
N9A08_07815	COG3185	4-Hydroxyphenylpyruvate dioxygenase
N9A08_07820	COG1414	Transcriptional regulator
N9A08_07825	COG2066	Belongs to the glutaminase family
N9A08_07830	COG0531	amino acid
N9A08_07835	COG0076	glutamate decarboxylase activity
N9A08_07845	COG2814	Major facilitator Superfamily
N9A08_07850	COG1902	pentaerythritol trinitrate reductase activity
N9A08_07855	COG2050	protein possibly involved in aromatic compounds catabolism
N9A08_07865	COG4552	Acetyltransferase involved in intracellular survival and related
N9A08_07870	COG0539	negative regulation of cytoplasmic translation
N9A08_07885	COG2723	6-phospho-beta-galactosidase activity
N9A08_07890	COG0395	ABC-type sugar transport system, permease component
N9A08_07895	COG1175	transmembrane transport
N9A08_07910	COG1739	Uncharacterized protein family UPF0029
N9A08_07915	COG0237	dephospho-CoA kinase activity
N9A08_07915	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
N9A08_07920	COG0556	nucleotide-excision repair
N9A08_07955	COG4106	trans-aconitate 2-methyltransferase activity
N9A08_07995	COG0322	excinuclease ABC activity
N9A08_08000	COG1660	Displays ATPase and GTPase activities
N9A08_08010	COG1481	regulation of sporulation
N9A08_08015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N9A08_08025	COG0126	phosphoglycerate kinase activity
N9A08_08030	COG0149	triose-phosphate isomerase activity
N9A08_08035	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N9A08_08040	COG0363	glucosamine-6-phosphate deaminase activity
N9A08_08055	COG0166	Belongs to the GPI family
N9A08_08060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N9A08_08070	COG0109	protoheme IX farnesyltransferase activity
N9A08_08075	COG1612	heme a metabolic process
N9A08_08085	COG1131	(ABC) transporter
N9A08_08105	COG0396	ATPase activity
N9A08_08110	COG2151	metal-sulfur cluster biosynthetic enzyme
N9A08_08120	COG1122	ATPase activity
N9A08_08125	COG1268	BioY protein
N9A08_08130	COG0488	(ABC) transporter
N9A08_08155	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_08165	COG1119	ATPase activity
N9A08_08185	COG0254	rRNA binding
N9A08_08190	COG0095	Lipoate-protein ligase
N9A08_08210	COG2855	membrane
N9A08_08225	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N9A08_08230	COG0297	glycogen (starch) synthase activity
N9A08_08250	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_08260	COG3844	kynureninase activity
N9A08_08265	COG0589	response to stress
N9A08_08275	COG1253	flavin adenine dinucleotide binding
N9A08_08285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N9A08_08305	COG1968	undecaprenyl-diphosphatase activity
N9A08_08310	COG0215	cysteine-tRNA ligase activity
N9A08_08320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N9A08_08340	COG4122	O-methyltransferase activity
N9A08_08350	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N9A08_08355	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N9A08_08360	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N9A08_08375	COG2378	regulation of single-species biofilm formation
N9A08_08385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N9A08_08390	COG0805	protein transport
N9A08_08395	COG4581	dead DEAH box helicase
N9A08_08400	COG1574	metal-dependent hydrolase with the TIM-barrel fold
N9A08_08405	COG1216	Glycosyl transferase, family 2
N9A08_08430	COG1506	peptidase
N9A08_08430	COG4946	Tricorn protease homolog
N9A08_08430	COG0823	Involved in the tonB-independent uptake of proteins
N9A08_08435	COG0242	peptide deformylase activity
N9A08_08450	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_08490	COG1136	(ABC) transporter
N9A08_08510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N9A08_08515	COG1845	cytochrome c oxidase, subunit III
N9A08_08520	COG2010	Cytochrome c
N9A08_08525	COG0723	plastoquinol--plastocyanin reductase activity
N9A08_08530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N9A08_08540	COG2188	Transcriptional regulator
N9A08_08550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N9A08_08555	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N9A08_08575	COG0167	dihydroorotate dehydrogenase activity
N9A08_08585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N9A08_08590	COG1381	Involved in DNA repair and RecF pathway recombination
N9A08_08595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N9A08_08600	COG1316	TRANSCRIPTIONal
N9A08_08605	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N9A08_08615	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N9A08_08635	COG0484	heat shock protein binding
N9A08_08640	COG1420	regulation of RNA biosynthetic process
N9A08_08660	COG0481	GTPase activity
N9A08_08670	COG0268	Binds directly to 16S ribosomal RNA
N9A08_08695	COG1307	EDD domain protein, DegV family
N9A08_08700	COG0495	leucyl-tRNA aminoacylation
N9A08_08705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N9A08_08710	COG0385	Bile acid
N9A08_08715	COG2072	flavoprotein involved in K transport
N9A08_08720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N9A08_08725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N9A08_08730	COG0656	L-ascorbic acid biosynthetic process
N9A08_08735	COG0596	Alpha beta hydrolase
N9A08_08740	COG0438	transferase activity, transferring glycosyl groups
N9A08_08745	COG2130	NADP-dependent
N9A08_08765	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N9A08_08775	COG1758	RNA polymerase activity
N9A08_08780	COG0194	GDP metabolic process
N9A08_08785	COG0194	GDP metabolic process
N9A08_08790	COG0284	orotidine-5'-phosphate decarboxylase activity
N9A08_08795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N9A08_08800	COG0505	Belongs to the CarA family
N9A08_08810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N9A08_08815	COG0540	Belongs to the ATCase OTCase family
N9A08_08820	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
N9A08_08830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N9A08_08835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N9A08_08840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N9A08_08850	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N9A08_08855	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N9A08_08865	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N9A08_08870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N9A08_08885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N9A08_08895	COG0384	phenazine biosynthesis protein PhzF
N9A08_08905	COG0384	phenazine biosynthesis protein PhzF
N9A08_08915	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N9A08_08925	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N9A08_08970	COG0583	DNA-binding transcription factor activity
N9A08_08975	COG5006	permease, DMT superfamily
N9A08_09005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N9A08_09010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N9A08_09015	COG1116	anion transmembrane transporter activity
N9A08_09020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N9A08_09030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N9A08_09045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N9A08_09050	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
N9A08_09055	COG0778	Nitroreductase
N9A08_09055	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
N9A08_09060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N9A08_09065	COG0124	histidyl-tRNA synthetase
N9A08_09075	COG1196	nuclear chromosome segregation
N9A08_09085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N9A08_09095	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N9A08_09105	COG2255	four-way junction helicase activity
N9A08_09110	COG0632	four-way junction helicase activity
N9A08_09115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N9A08_09120	COG0217	transcriptional regulatory protein
N9A08_09125	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
N9A08_09130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N9A08_09155	COG0339	signal peptide processing
N9A08_09165	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
N9A08_09170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N9A08_09180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N9A08_09185	COG0587	DNA-directed DNA polymerase activity
N9A08_09210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N9A08_09220	COG2409	Drug exporters of the RND superfamily
N9A08_09265	COG0366	Alpha amylase catalytic
N9A08_09265	COG3103	Sh3 type 3 domain protein
N9A08_09280	COG0667	Aldo Keto reductase
N9A08_09285	COG2135	peptidase activity
N9A08_09300	COG0346	lactoylglutathione lyase activity
N9A08_09305	COG0640	Transcriptional regulator
N9A08_09325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N9A08_09345	COG0667	Aldo Keto reductase
N9A08_09370	COG1231	oxidoreductase activity
N9A08_09385	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N9A08_09390	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N9A08_09395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N9A08_09400	COG1780	Probably involved in ribonucleotide reductase function
N9A08_09405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N9A08_09410	COG0583	DNA-binding transcription factor activity
N9A08_09430	COG3621	Patatin-like phospholipase
N9A08_09435	COG0789	Transcriptional regulator
N9A08_09450	COG2814	Major facilitator Superfamily
N9A08_09465	COG3268	Saccharopine dehydrogenase
N9A08_09485	COG0799	negative regulation of ribosome biogenesis
N9A08_09495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N9A08_09505	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N9A08_09510	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N9A08_09515	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N9A08_09520	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N9A08_09525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N9A08_09530	COG1530	ribonuclease E activity
N9A08_09545	COG0105	UTP biosynthetic process
N9A08_09555	COG0285	dihydrofolate synthase activity
N9A08_09560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N9A08_09565	COG4221	oxidoreductase activity
N9A08_09580	COG3189	MarR family transcriptional regulator
N9A08_09585	COG0525	valine-tRNA ligase activity
N9A08_09590	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N9A08_09595	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N9A08_09600	COG0740	serine-type endopeptidase activity
N9A08_09605	COG0740	serine-type endopeptidase activity
N9A08_09610	COG0544	peptidyl-prolyl cis-trans isomerase activity
N9A08_09650	COG0668	transmembrane transport
N9A08_09670	COG1946	Acyl-CoA thioesterase
N9A08_09685	COG0629	single-stranded DNA binding
N9A08_09775	COG3022	response to hydroperoxide
N9A08_09790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N9A08_09795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N9A08_09805	COG1045	serine acetyltransferase
N9A08_09810	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N9A08_09850	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N9A08_09865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N9A08_09870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N9A08_09875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N9A08_09885	COG4974	Belongs to the 'phage' integrase family
N9A08_09890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N9A08_09905	COG0792	nuclease activity
N9A08_09925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N9A08_09930	COG0681	Belongs to the peptidase S26 family
N9A08_09935	COG0681	Belongs to the peptidase S26 family
N9A08_09940	COG0335	large ribosomal subunit rRNA binding
N9A08_09945	COG0336	Belongs to the RNA methyltransferase TrmD family
N9A08_09950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N9A08_09955	COG1837	Belongs to the UPF0109 family
N9A08_09960	COG0228	four-way junction DNA binding
N9A08_09965	COG2514	catechol 2,3-dioxygenase activity
N9A08_10005	COG0477	Major facilitator Superfamily
N9A08_10015	COG1196	nuclear chromosome segregation
N9A08_10020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N9A08_10025	COG0318	PFAM AMP-dependent synthetase and ligase
N9A08_10030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N9A08_10035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N9A08_10040	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N9A08_10045	COG0571	ribonuclease III activity
N9A08_10050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N9A08_10065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N9A08_10080	COG0742	ribosomal rna small subunit methyltransferase
N9A08_10090	COG1461	Dihydroxyacetone kinase
N9A08_10095	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N9A08_10110	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
N9A08_10120	COG1134	teichoic acid transport
N9A08_10125	COG1682	transport, permease protein
N9A08_10140	COG1316	TRANSCRIPTIONal
N9A08_10150	COG1181	Belongs to the D-alanine--D-alanine ligase family
N9A08_10155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N9A08_10165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N9A08_10170	COG0066	3-isopropylmalate dehydratase activity
N9A08_10175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N9A08_10180	COG1414	Transcriptional regulator
N9A08_10185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N9A08_10210	COG0546	phosphoglycolate phosphatase activity
N9A08_10215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N9A08_10225	COG0179	Fumarylacetoacetate (FAA) hydrolase
N9A08_10250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N9A08_10255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N9A08_10260	COG0473	3-isopropylmalate dehydrogenase activity
N9A08_10265	COG4585	Histidine kinase
N9A08_10270	COG2197	response regulator
N9A08_10275	COG0577	efflux transmembrane transporter activity
N9A08_10275	COG1136	(ABC) transporter
N9A08_10280	COG1136	(ABC) transporter
N9A08_10280	COG0577	efflux transmembrane transporter activity
N9A08_10300	COG1136	(ABC) transporter
N9A08_10300	COG0577	efflux transmembrane transporter activity
N9A08_10305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N9A08_10310	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N9A08_10315	COG0440	acetolactate synthase activity
N9A08_10325	COG0129	dihydroxy-acid dehydratase activity
N9A08_10380	COG0747	negative chemotaxis
N9A08_10385	COG0601	transmembrane transport
N9A08_10390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N9A08_10395	COG4172	Belongs to the ABC transporter superfamily
N9A08_10400	COG0747	negative chemotaxis
N9A08_10405	COG0579	oxidoreductase
N9A08_10410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N9A08_10415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N9A08_10430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N9A08_10435	COG1104	cysteine desulfurase activity
N9A08_10445	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N9A08_10450	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
N9A08_10470	COG0022	dehydrogenase e1 component
N9A08_10475	COG0508	dehydrogenase complex catalyzes the overall conversion of
N9A08_10485	COG0515	serine threonine protein kinase
N9A08_10485	COG2815	serine threonine protein kinase
N9A08_10495	COG1116	anion transmembrane transporter activity
N9A08_10500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N9A08_10520	COG0419	ATPase involved in DNA repair
N9A08_10525	COG0420	3'-5' exonuclease activity
N9A08_10545	COG0586	Pfam SNARE associated Golgi protein
N9A08_10550	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N9A08_10555	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N9A08_10560	COG1234	tRNA 3'-trailer cleavage
N9A08_10565	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N9A08_10575	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N9A08_10585	COG1335	isochorismatase
N9A08_10635	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
N9A08_10645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N9A08_10655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N9A08_10660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N9A08_10665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N9A08_10670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N9A08_10675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N9A08_10680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N9A08_10685	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N9A08_10690	COG0356	it plays a direct role in the translocation of protons across the membrane
N9A08_10705	COG1086	Polysaccharide biosynthesis protein
N9A08_10715	COG1216	Glycosyl transferase, family 2
N9A08_10720	COG0039	L-malate dehydrogenase activity
N9A08_10730	COG2890	protein-(glutamine-N5) methyltransferase activity
N9A08_10735	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N9A08_10745	COG0083	homoserine kinase activity
N9A08_10750	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N9A08_10755	COG0460	homoserine dehydrogenase
N9A08_10760	COG0019	diaminopimelate decarboxylase activity
N9A08_10765	COG0018	arginyl-trna synthetase
N9A08_10780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N9A08_10790	COG0577	efflux transmembrane transporter activity
N9A08_10790	COG1136	(ABC) transporter
N9A08_10795	COG1136	(ABC) transporter
N9A08_10795	COG0577	efflux transmembrane transporter activity
N9A08_10820	COG1643	Atp-dependent helicase
N9A08_10825	COG0537	adenosine 5'-monophosphoramidase activity
N9A08_10850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N9A08_10855	COG1121	(ABC) transporter
N9A08_10870	COG1253	flavin adenine dinucleotide binding
N9A08_10875	COG0508	dehydrogenase complex catalyzes the overall conversion of
N9A08_10875	COG0567	Dehydrogenase, E1 component
N9A08_10885	COG0604	alcohol dehydrogenase
N9A08_10895	COG1595	DNA-templated transcription, initiation
N9A08_10905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N9A08_10915	COG0483	inositol monophosphate 1-phosphatase activity
N9A08_10925	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N9A08_10930	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N9A08_10935	COG0366	Alpha amylase catalytic
N9A08_10980	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N9A08_10990	COG2177	Part of the ABC transporter FtsEX involved in
N9A08_10995	COG2884	Cell division ATP-binding protein ftsE
N9A08_11005	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_11015	COG0318	PFAM AMP-dependent synthetase and ligase
N9A08_11045	COG2755	lipolytic protein G-D-S-L family
N9A08_11045	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N9A08_11050	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N9A08_11095	COG1215	transferase activity, transferring glycosyl groups
N9A08_11105	COG0463	Glycosyl transferase, family 2
N9A08_11130	COG1088	dTDP-glucose 4,6-dehydratase activity
N9A08_11140	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
N9A08_11155	COG1216	Glycosyl transferase, family 2
N9A08_11165	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N9A08_11165	COG2755	lipolytic protein G-D-S-L family
N9A08_11170	COG1674	ftsk spoiiie
N9A08_11190	COG2902	Dehydrogenase
N9A08_11225	COG0653	protein targeting
N9A08_11230	COG3214	Protein conserved in bacteria
N9A08_11235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N9A08_11240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N9A08_11245	COG5401	PFAM Sporulation and spore germination
N9A08_11250	COG5002	protein histidine kinase activity
N9A08_11255	COG0745	RESPONSE REGULATOR receiver
N9A08_11275	COG0714	Associated with various cellular activities
N9A08_11300	COG0482	sulfurtransferase activity
N9A08_11315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N9A08_11325	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N9A08_11330	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
N9A08_11335	COG2086	electron transfer activity
N9A08_11340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N9A08_11350	COG1842	Phage shock protein A
N9A08_11360	COG1615	UPF0182 protein
N9A08_11365	COG3480	Lon protease (S16) C-terminal proteolytic domain
N9A08_11405	COG1131	(ABC) transporter
N9A08_11415	COG0210	DNA helicase
N9A08_11435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N9A08_11445	COG1464	Belongs to the NlpA lipoprotein family
N9A08_11450	COG1131	(ABC) transporter
N9A08_11460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N9A08_11465	COG0113	porphobilinogen synthase activity
N9A08_11475	COG0181	hydroxymethylbilane synthase activity
N9A08_11480	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N9A08_11485	COG3253	May function as heme-dependent peroxidase
N9A08_11495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N9A08_11500	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N9A08_11535	COG0513	Belongs to the DEAD box helicase family
N9A08_11545	COG0613	PHP domain protein
N9A08_11550	COG0006	proline dipeptidase activity
N9A08_11560	COG2239	Acts as a magnesium transporter
N9A08_11575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N9A08_11585	COG1595	DNA-templated transcription, initiation
N9A08_11595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N9A08_11605	COG0519	Catalyzes the synthesis of GMP from XMP
N9A08_11615	COG1611	Belongs to the LOG family
N9A08_11620	COG1126	abc transporter atp-binding protein
N9A08_11625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N9A08_11630	COG0765	amino acid transport
N9A08_11635	COG0765	amino acid transport
N9A08_11640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N9A08_11645	COG2171	N-acyltransferase activity
N9A08_11655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N9A08_11690	COG1217	gtp-binding protein TYPA
N9A08_11700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N9A08_11710	COG4166	transmembrane transport
N9A08_11715	COG4172	Belongs to the ABC transporter superfamily
N9A08_11725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N9A08_11735	COG4166	transmembrane transport
N9A08_11775	COG5504	Zn-dependent protease
N9A08_11810	COG0012	GTP binding
N9A08_11815	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N9A08_11825	COG1570	exodeoxyribonuclease VII activity
N9A08_11830	COG1722	exodeoxyribonuclease VII activity
N9A08_11860	COG0494	nUDIX hydrolase
N9A08_11865	COG2971	BadF BadG BcrA BcrD
N9A08_11880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N9A08_11885	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N9A08_11915	COG0519	Catalyzes the synthesis of GMP from XMP
N9A08_11915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N9A08_11935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N9A08_11940	COG0516	GMP reductase activity
N9A08_11950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N9A08_11950	COG2755	lipolytic protein G-D-S-L family
N9A08_11955	COG0459	protein refolding
N9A08_11960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N9A08_11965	COG4607	ABC-type enterochelin transport system periplasmic component
N9A08_11970	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N9A08_11975	COG4605	iron ion homeostasis
N9A08_11980	COG4604	ABC transporter, ATP-binding protein
N9A08_12005	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
N9A08_12015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N9A08_12020	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N9A08_12030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N9A08_12040	COG1214	PFAM Peptidase M22, glycoprotease
N9A08_12040	COG0456	acetyltransferase
N9A08_12070	COG0802	atpase or kinase
N9A08_12075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N9A08_12085	COG0667	Aldo Keto reductase
N9A08_12110	COG0736	holo-[acyl-carrier-protein] synthase activity
N9A08_12120	COG1072	(Pantothenic acid kinase))
N9A08_12125	COG1970	mechanosensitive ion channel activity
N9A08_12130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N9A08_12135	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N9A08_12140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N9A08_12145	COG0101	tRNA pseudouridine synthase activity
N9A08_12150	COG0203	ribosomal protein L17
N9A08_12155	COG0202	RNA polymerase activity
N9A08_12160	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N9A08_12165	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N9A08_12170	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N9A08_12175	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N9A08_12195	COG1175	transmembrane transport
N9A08_12210	COG0024	Methionine aminopeptidase
N9A08_12215	COG0563	adenylate kinase activity
N9A08_12225	COG0200	Binds to the 23S rRNA
N9A08_12230	COG1841	ribosomal large subunit assembly
N9A08_12235	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N9A08_12245	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N9A08_12250	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N9A08_12255	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N9A08_12260	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N9A08_12265	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N9A08_12270	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N9A08_12280	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N9A08_12285	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N9A08_12290	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N9A08_12295	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N9A08_12300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N9A08_12305	COG0089	rRNA binding
N9A08_12310	COG0088	Forms part of the polypeptide exit tunnel
N9A08_12315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N9A08_12320	COG0051	transcription antitermination factor activity, RNA binding
N9A08_12335	COG0318	PFAM AMP-dependent synthetase and ligase
N9A08_12340	COG1960	acyl-CoA dehydrogenase activity
N9A08_12345	COG1902	pentaerythritol trinitrate reductase activity
N9A08_12345	COG0446	pyridine nucleotide-disulphide oxidoreductase
N9A08_12350	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N9A08_12355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N9A08_12360	COG0049	tRNA binding
N9A08_12365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N9A08_12370	COG1414	Transcriptional regulator
N9A08_12375	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N9A08_12385	COG0183	Belongs to the thiolase family
N9A08_12390	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N9A08_12405	COG3485	protocatechuate 3,4-dioxygenase
N9A08_12410	COG3485	protocatechuate 3,4-dioxygenase
N9A08_12425	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N9A08_12430	COG0085	RNA polymerase activity
N9A08_12435	COG0183	Belongs to the thiolase family
N9A08_12440	COG0442	prolyl-tRNA aminoacylation
N9A08_12445	COG0222	ribosome binding
N9A08_12450	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N9A08_12460	COG0081	regulation of translation
N9A08_12465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N9A08_12485	COG0436	Aminotransferase
N9A08_12490	COG2197	response regulator
N9A08_12530	COG0354	folic acid binding
N9A08_12535	COG3485	protocatechuate 3,4-dioxygenase
N9A08_12545	COG0745	RESPONSE REGULATOR receiver
N9A08_12550	COG0456	acetyltransferase
N9A08_12555	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N9A08_12565	COG1528	Iron-storage protein
N9A08_12575	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
N9A08_12580	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N9A08_12585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N9A08_12590	COG2814	Major facilitator Superfamily
N9A08_12600	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N9A08_12610	COG2030	dehydratase
N9A08_12625	COG1012	belongs to the aldehyde dehydrogenase family
N9A08_12645	COG0693	protein deglycase activity
N9A08_12665	COG0515	serine threonine protein kinase
N9A08_12720	COG1063	alcohol dehydrogenase
N9A08_12725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N9A08_12745	COG1666	GTP binding
N9A08_12785	COG0305	Participates in initiation and elongation during chromosome replication
N9A08_12890	COG0739	heme binding
N9A08_12945	COG0501	Belongs to the peptidase M48B family
N9A08_12955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N9A08_13005	COG0142	geranyltranstransferase activity
N9A08_13010	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
N9A08_13030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N9A08_13035	COG0179	Fumarylacetoacetate (FAA) hydrolase
N9A08_13050	COG1309	transcriptional regulator
N9A08_13060	COG1116	anion transmembrane transporter activity
N9A08_13065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N9A08_13070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N9A08_13075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N9A08_13080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N9A08_13095	COG3971	2-oxopent-4-enoate hydratase activity
N9A08_13110	COG0657	acetylesterase activity
N9A08_13125	COG2409	Drug exporters of the RND superfamily
N9A08_13155	COG0477	Major facilitator Superfamily
N9A08_13215	COG0142	geranyltranstransferase activity
N9A08_13225	COG2226	methyltransferase
N9A08_13235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N9A08_13240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N9A08_13245	COG0765	amino acid transport
N9A08_13255	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
N9A08_13260	COG4948	Mandelate Racemase Muconate Lactonizing
N9A08_13280	COG0508	dehydrogenase complex catalyzes the overall conversion of
N9A08_13285	COG0022	dehydrogenase e1 component
N9A08_13305	COG2837	iron assimilation
N9A08_13330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N9A08_13335	COG2151	metal-sulfur cluster biosynthetic enzyme
N9A08_13340	COG3396	Phenylacetate-CoA oxygenase
N9A08_13345	COG3460	Phenylacetate-CoA oxygenase
N9A08_13350	COG3396	Phenylacetate-CoA oxygenase
N9A08_13365	COG0586	Pfam SNARE associated Golgi protein
N9A08_13370	COG2050	protein possibly involved in aromatic compounds catabolism
N9A08_13385	COG1012	belongs to the aldehyde dehydrogenase family
N9A08_13385	COG2030	dehydratase
N9A08_13395	COG1063	alcohol dehydrogenase
N9A08_13420	COG1250	3-hydroxyacyl-CoA dehydrogenase
N9A08_13425	COG1024	Enoyl-CoA hydratase
N9A08_13440	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
N9A08_13445	COG2031	fatty acid transporter
N9A08_13455	COG1024	Enoyl-CoA hydratase
N9A08_13465	COG1250	3-hydroxyacyl-CoA dehydrogenase
N9A08_13480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N9A08_13505	COG1140	nitrate reductase beta subunit
N9A08_13515	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
N9A08_13545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N9A08_13555	COG0785	Cytochrome C biogenesis protein
N9A08_13565	COG0406	alpha-ribazole phosphatase activity
N9A08_13570	COG2353	YceI-like domain
N9A08_13585	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
N9A08_13610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N9A08_13620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N9A08_13625	COG0640	Transcriptional regulator
N9A08_13630	COG0123	including yeast histone deacetylase and acetoin utilization protein
N9A08_13635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N9A08_13640	COG0569	domain protein
N9A08_13650	COG1082	Xylose isomerase domain protein TIM barrel
N9A08_13655	COG0248	Ppx GppA phosphatase
N9A08_13660	COG1754	DNA topoisomerase type I activity
N9A08_13660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N9A08_13665	COG2890	protein-(glutamine-N5) methyltransferase activity
N9A08_13670	COG2814	Major facilitator Superfamily
N9A08_13680	COG1054	Belongs to the UPF0176 family
N9A08_13690	COG1111	helicase
N9A08_13690	COG1205	dead DEAH box helicase
N9A08_13740	COG4585	Histidine kinase
N9A08_13745	COG2197	response regulator
N9A08_13750	COG0494	nUDIX hydrolase
N9A08_13755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N9A08_13765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N9A08_13770	COG1764	response to oxidative stress
N9A08_13780	COG0477	Major facilitator Superfamily
N9A08_13805	COG0251	oxidation-reduction process
N9A08_13815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N9A08_13820	COG1408	metallophosphoesterase
N9A08_13825	COG1132	(ABC) transporter
N9A08_13830	COG1132	(ABC) transporter
N9A08_13845	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N9A08_13850	COG0151	Belongs to the GarS family
N9A08_13875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N9A08_13900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N9A08_13905	COG1012	belongs to the aldehyde dehydrogenase family
N9A08_13915	COG0768	penicillin binding
N9A08_13925	COG3304	Inner membrane component domain
N9A08_13940	COG0513	Belongs to the DEAD box helicase family
N9A08_13945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N9A08_13965	COG1131	(ABC) transporter
N9A08_13975	COG0789	Transcriptional regulator
N9A08_13980	COG0484	heat shock protein binding
N9A08_13985	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N9A08_13990	COG0443	Heat shock 70 kDa protein
N9A08_14000	COG2226	methyltransferase
N9A08_14005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N9A08_14015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N9A08_14030	COG1122	ATPase activity
N9A08_14035	COG4721	ABC-type cobalt transport system, permease component
N9A08_14050	COG2212	antiporter activity
N9A08_14060	COG0651	ATP synthesis coupled electron transport
N9A08_14070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N9A08_14070	COG2111	Na H antiporter
N9A08_14085	COG0717	Belongs to the dCTP deaminase family
N9A08_14090	COG3483	tryptophan 2,3-dioxygenase activity
N9A08_14115	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
N9A08_14150	COG3336	cytochrome c oxidase
N9A08_14155	COG0776	regulation of translation
N9A08_14160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N9A08_14165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N9A08_14170	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N9A08_14175	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N9A08_14185	COG0477	Major facilitator Superfamily
N9A08_14195	COG1597	lipid kinase activity
N9A08_14200	COG0739	heme binding
N9A08_14210	COG1120	ATPase activity
N9A08_14215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N9A08_14220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N9A08_14225	COG0435	Glutathione S-transferase
N9A08_14240	COG1295	ribonuclease BN
N9A08_14300	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
N9A08_14315	COG2813	Specifically methylates the guanine in position
N9A08_14335	COG0531	amino acid
N9A08_14350	COG1473	amidohydrolase
N9A08_14355	COG4585	Histidine kinase
N9A08_14360	COG2197	response regulator
N9A08_14365	COG4152	abc transporter atp-binding protein
N9A08_14375	COG0477	Major facilitator Superfamily
N9A08_14390	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_14395	COG0318	PFAM AMP-dependent synthetase and ligase
N9A08_14400	COG1309	transcriptional regulator
N9A08_14425	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N9A08_14430	COG1414	Transcriptional regulator
N9A08_14470	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_14495	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_14500	COG1024	Enoyl-CoA hydratase
N9A08_14510	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_14515	COG1012	belongs to the aldehyde dehydrogenase family
N9A08_14530	COG0318	PFAM AMP-dependent synthetase and ligase
N9A08_14540	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
N9A08_14545	COG1473	amidohydrolase
N9A08_14550	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_14570	COG0028	Belongs to the TPP enzyme family
N9A08_14580	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N9A08_14595	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N9A08_14600	COG0596	Alpha beta hydrolase
N9A08_14605	COG5002	protein histidine kinase activity
N9A08_14620	COG2814	Major facilitator Superfamily
N9A08_14625	COG3254	rhamnose metabolic process
N9A08_14630	COG4952	isomerase
N9A08_14635	COG3347	Dehydrogenase
N9A08_14635	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_14640	COG1070	Carbohydrate kinase
N9A08_14645	COG1609	Transcriptional regulator
N9A08_14655	COG1072	(Pantothenic acid kinase))
N9A08_14675	COG3842	ATPase activity
N9A08_14680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N9A08_14685	COG1176	ABC-type spermidine putrescine transport system, permease component I
N9A08_14690	COG1177	transmembrane transport
N9A08_14720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N9A08_14730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N9A08_14740	COG3842	ATPase activity
N9A08_14745	COG1175	transmembrane transport
N9A08_14765	COG1012	belongs to the aldehyde dehydrogenase family
N9A08_14775	COG0366	Alpha amylase catalytic
N9A08_14785	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
N9A08_14790	COG3639	organic phosphonate transmembrane transporter activity
N9A08_14810	COG0656	L-ascorbic acid biosynthetic process
N9A08_14830	COG2197	response regulator
N9A08_14835	COG4585	Histidine kinase
N9A08_14850	COG1846	Transcriptional regulator
N9A08_14865	COG1846	Transcriptional regulator
N9A08_14875	COG2807	transmembrane transport
N9A08_14905	COG0583	DNA-binding transcription factor activity
N9A08_14925	COG1280	lysine exporter protein (LysE YggA)
N9A08_14930	COG1522	sequence-specific DNA binding
N9A08_14945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N9A08_14955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N9A08_14985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N9A08_14995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N9A08_15000	COG0477	Major facilitator Superfamily
N9A08_15005	COG1957	nucleoside hydrolase
N9A08_15010	COG2076	Multidrug Resistance protein
N9A08_15015	COG2076	Multidrug Resistance protein
N9A08_15030	COG0531	amino acid
N9A08_15035	COG2205	protein histidine kinase activity
N9A08_15040	COG0745	RESPONSE REGULATOR receiver
N9A08_15100	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
N9A08_15150	COG1121	(ABC) transporter
N9A08_15155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N9A08_15165	COG2217	Heavy metal translocating P-type atpase
N9A08_15175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N9A08_15215	COG1902	pentaerythritol trinitrate reductase activity
N9A08_15245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N9A08_15255	COG0803	Belongs to the bacterial solute-binding protein 9 family
N9A08_15255	COG3443	Belongs to the bacterial solute-binding protein 9 family
N9A08_15270	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
N9A08_15295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N9A08_15300	COG3422	double-strand break repair
N9A08_15310	COG1120	ATPase activity
N9A08_15330	COG0515	serine threonine protein kinase
N9A08_15355	COG1012	belongs to the aldehyde dehydrogenase family
N9A08_15385	COG1178	ABC-type Fe3 transport system permease component
N9A08_15390	COG3842	ATPase activity
N9A08_15400	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_15415	COG0598	Magnesium transport protein CorA
N9A08_15455	COG1028	Short-chain dehydrogenase reductase Sdr
N9A08_15460	COG2814	Major facilitator Superfamily
N9A08_15470	COG0477	Major facilitator Superfamily
N9A08_15480	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N9A08_15485	COG2301	Belongs to the HpcH HpaI aldolase family
N9A08_15500	COG2409	Drug exporters of the RND superfamily
N9A08_15510	COG0277	FAD linked oxidase domain protein
N9A08_15515	COG1620	l-lactate permease
N9A08_15545	COG0509	glycine decarboxylation via glycine cleavage system
N9A08_15550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N9A08_15555	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N9A08_15555	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N9A08_15560	COG1113	amino acid transport
N9A08_15565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N9A08_15595	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N9A08_15610	COG0686	Belongs to the AlaDH PNT family
N9A08_15620	COG0673	inositol 2-dehydrogenase activity
N9A08_15655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N9A08_15665	COG0508	dehydrogenase complex catalyzes the overall conversion of
N9A08_15670	COG0022	dehydrogenase e1 component
N9A08_15680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N9A08_15685	COG1950	PFAM Membrane protein of
N9A08_15700	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N9A08_15705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N9A08_15720	COG0590	tRNA wobble adenosine to inosine editing
N9A08_15725	COG3386	PFAM SMP-30 Gluconolaconase
N9A08_15730	COG2807	transmembrane transport
N9A08_15745	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
N9A08_15760	COG1063	alcohol dehydrogenase
N9A08_15765	COG0395	ABC-type sugar transport system, permease component
N9A08_15770	COG1175	transmembrane transport
N9A08_15795	COG0246	Mannitol dehydrogenase
N9A08_15825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N9A08_15830	COG1595	DNA-templated transcription, initiation
N9A08_15835	COG1960	acyl-CoA dehydrogenase activity
N9A08_15845	COG0659	secondary active sulfate transmembrane transporter activity
N9A08_15855	COG0019	diaminopimelate decarboxylase activity
N9A08_15860	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
N9A08_15870	COG2197	response regulator
N9A08_15885	COG1058	Belongs to the CinA family
N9A08_15885	COG1546	Belongs to the CinA family
N9A08_15900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N9A08_15915	COG3226	Transcriptional regulator
N9A08_15920	COG0738	Major facilitator superfamily
N9A08_15930	COG0318	PFAM AMP-dependent synthetase and ligase
N9A08_15940	COG0697	spore germination
N9A08_15970	COG0534	Mate efflux family protein
N9A08_15975	COG2814	Major facilitator Superfamily
N9A08_15990	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
N9A08_15995	COG3583	domain protein
N9A08_16000	COG0531	amino acid
N9A08_16005	COG3634	alkyl hydroperoxide reductase activity
N9A08_16020	COG0305	Participates in initiation and elongation during chromosome replication
N9A08_16025	COG0359	binds to the 23S rRNA
N9A08_16030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N9A08_16040	COG0360	Binds together with S18 to 16S ribosomal RNA
N9A08_16045	COG1362	aminopeptidase activity
N9A08_16055	COG1131	(ABC) transporter
N9A08_16080	COG0738	Major facilitator superfamily
N9A08_16085	COG0488	(ABC) transporter
N9A08_16135	COG2759	Belongs to the formate--tetrahydrofolate ligase family
N9A08_16140	COG0438	transferase activity, transferring glycosyl groups
N9A08_16150	COG0588	phosphoglycerate mutase activity
N9A08_16155	COG0617	tRNA 3'-terminal CCA addition
N9A08_16175	COG0492	ferredoxin-NADP+ reductase activity
N9A08_16180	COG3118	belongs to the thioredoxin family
N9A08_16185	COG0860	N-Acetylmuramoyl-L-alanine amidase
N9A08_16185	COG3409	Peptidoglycan-binding domain 1 protein
N9A08_16195	COG1475	DNA binding
N9A08_16200	COG1192	Involved in chromosome partitioning
N9A08_16205	COG0357	Ribosomal RNA small subunit methyltransferase G
N9A08_16215	COG0706	membrane insertase activity
N9A08_16220	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N9A08_16225	COG0594	ribonuclease P activity
N9A08_16230	COG0230	Belongs to the bacterial ribosomal protein bL34 family