locus-tag	class	description
PBI_DRMANHATTAN_40	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PBI_DRMANHATTAN_40	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PBI_DRMANHATTAN_42	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PBI_DRMANHATTAN_52	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PBI_DRMANHATTAN_60	COG0739	heme binding