locus-tag	class	description
J0916_00035	COG2801	Transposase and inactivated derivatives
J0916_00065	COG2226	methyltransferase
J0916_00080	COG3547	Transposase (IS116 IS110 IS902 family)
J0916_00090	COG4974	Belongs to the 'phage' integrase family
J0916_00100	COG4974	Belongs to the 'phage' integrase family
J0916_00115	COG0717	Belongs to the dCTP deaminase family
J0916_00140	COG0124	histidyl-tRNA synthetase
J0916_00150	COG1484	DNA-dependent DNA replication
J0916_00235	COG2855	membrane
J0916_00245	COG1012	belongs to the aldehyde dehydrogenase family
J0916_00250	COG0596	Alpha beta hydrolase
J0916_00270	COG2207	Transcriptional regulator
J0916_00280	COG0604	alcohol dehydrogenase
J0916_00305	COG0492	ferredoxin-NADP+ reductase activity
J0916_00365	COG2197	response regulator
J0916_00440	COG1404	Belongs to the peptidase S8 family
J0916_00445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J0916_00510	COG2197	response regulator
J0916_00525	COG1126	abc transporter atp-binding protein
J0916_00530	COG0765	amino acid transport
J0916_00555	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_00570	COG1653	transport
J0916_00590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J0916_00595	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J0916_00615	COG0667	Aldo Keto reductase
J0916_00620	COG0701	Predicted permease
J0916_00650	COG3608	succinylglutamate desuccinylase aspartoacylase
J0916_00660	COG0765	amino acid transport
J0916_00665	COG1126	abc transporter atp-binding protein
J0916_00675	COG1609	Transcriptional regulator
J0916_00680	COG0366	Alpha amylase catalytic
J0916_00710	COG4172	Belongs to the ABC transporter superfamily
J0916_00740	COG3142	Participates in the control of copper homeostasis
J0916_00785	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J0916_00790	COG1012	belongs to the aldehyde dehydrogenase family
J0916_00820	COG1126	abc transporter atp-binding protein
J0916_00825	COG0765	amino acid transport
J0916_00830	COG0765	amino acid transport
J0916_00845	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_00855	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_00860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J0916_00865	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J0916_00895	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_00900	COG2130	NADP-dependent
J0916_00920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J0916_00930	COG3960	tartronate-semialdehyde synthase activity
J0916_00935	COG2084	Dehydrogenase
J0916_00940	COG3622	Belongs to the hyi family
J0916_00950	COG3257	ureidoglycine aminohydrolase activity
J0916_00960	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J0916_00970	COG1414	Transcriptional regulator
J0916_00975	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
J0916_00980	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_00995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J0916_01000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J0916_01005	COG0156	8-amino-7-oxononanoate synthase activity
J0916_01015	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J0916_01030	COG2233	PERMEase
J0916_01050	COG1937	Protein conserved in bacteria
J0916_01075	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_01090	COG1012	belongs to the aldehyde dehydrogenase family
J0916_01140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J0916_01160	COG0459	protein refolding
J0916_01165	COG0328	RNA-DNA hybrid ribonuclease activity
J0916_01175	COG2205	protein histidine kinase activity
J0916_01180	COG0745	RESPONSE REGULATOR receiver
J0916_01185	COG3119	arylsulfatase activity
J0916_01195	COG3119	arylsulfatase activity
J0916_01200	COG0395	ABC-type sugar transport system, permease component
J0916_01210	COG1653	transport
J0916_01215	COG1609	Transcriptional regulator
J0916_01220	COG0673	inositol 2-dehydrogenase activity
J0916_01240	COG5492	domain, Protein
J0916_01245	COG3119	arylsulfatase activity
J0916_01255	COG3119	arylsulfatase activity
J0916_01260	COG2890	protein-(glutamine-N5) methyltransferase activity
J0916_01280	COG1278	Cold shock
J0916_01300	COG0739	heme binding
J0916_01305	COG3103	Sh3 type 3 domain protein
J0916_01305	COG1388	LysM domain
J0916_01305	COG0791	NLP P60 protein
J0916_01345	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J0916_01355	COG1126	abc transporter atp-binding protein
J0916_01360	COG0765	amino acid transport
J0916_01365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J0916_01370	COG1132	(ABC) transporter
J0916_01385	COG1742	UPF0060 membrane protein
J0916_01405	COG0483	inositol monophosphate 1-phosphatase activity
J0916_01415	COG0045	succinate-CoA ligase (ADP-forming) activity
J0916_01450	COG0508	dehydrogenase complex catalyzes the overall conversion of
J0916_01470	COG1960	acyl-CoA dehydrogenase activity
J0916_01485	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_01490	COG2030	dehydratase
J0916_01520	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
J0916_01535	COG1396	sequence-specific DNA binding
J0916_01550	COG0028	Belongs to the TPP enzyme family
J0916_01555	COG1794	racemase activity, acting on amino acids and derivatives
J0916_01570	COG3119	arylsulfatase activity
J0916_01575	COG0326	Molecular chaperone. Has ATPase activity
J0916_01595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J0916_01615	COG0457	Tetratricopeptide repeat
J0916_01620	COG2186	Transcriptional regulator
J0916_01645	COG0431	NADPH-dependent FMN reductase
J0916_01685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J0916_01690	COG1574	metal-dependent hydrolase with the TIM-barrel fold
J0916_01710	COG0789	Transcriptional regulator
J0916_01715	COG0659	secondary active sulfate transmembrane transporter activity
J0916_01770	COG1960	acyl-CoA dehydrogenase activity
J0916_01785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J0916_01785	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J0916_01790	COG1278	Cold shock
J0916_01815	COG0477	Major facilitator Superfamily
J0916_01825	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
J0916_01830	COG1472	Belongs to the glycosyl hydrolase 3 family
J0916_01835	COG0138	bifunctional purine biosynthesis protein purh
J0916_01845	COG2838	Isocitrate dehydrogenase
J0916_01875	COG0673	inositol 2-dehydrogenase activity
J0916_01885	COG0395	ABC-type sugar transport system, permease component
J0916_01890	COG1175	transmembrane transport
J0916_01900	COG1940	carbohydrate kinase activity
J0916_01910	COG0667	Aldo Keto reductase
J0916_01920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J0916_01925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J0916_01940	COG2197	response regulator
J0916_01960	COG0180	Tryptophanyl-tRNA synthetase
J0916_01980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J0916_01995	COG2009	succinate dehydrogenase
J0916_02000	COG0662	Cupin 2, conserved barrel domain protein
J0916_02000	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
J0916_02005	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
J0916_02005	COG1473	amidohydrolase
J0916_02010	COG1744	ABC transporter substrate-binding protein PnrA-like
J0916_02015	COG3845	ABC transporter
J0916_02020	COG4603	Belongs to the binding-protein-dependent transport system permease family
J0916_02025	COG1079	Belongs to the binding-protein-dependent transport system permease family
J0916_02045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
J0916_02050	COG3956	TIGRFAM MazG family protein
J0916_02055	COG0148	phosphopyruvate hydratase activity
J0916_02110	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
J0916_02120	COG1349	DNA-binding transcription factor activity
J0916_02125	COG2017	converts alpha-aldose to the beta-anomer
J0916_02135	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J0916_02140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J0916_02150	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J0916_02160	COG1331	Highly conserved protein containing a thioredoxin domain
J0916_02165	COG0577	efflux transmembrane transporter activity
J0916_02165	COG1136	(ABC) transporter
J0916_02180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J0916_02190	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
J0916_02215	COG0477	Major facilitator Superfamily
J0916_02220	COG0114	fumarate hydratase activity
J0916_02225	COG0288	reversible hydration of carbon dioxide
J0916_02235	COG1494	fructose-1,6-bisphosphatase
J0916_02250	COG1316	TRANSCRIPTIONal
J0916_02315	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J0916_02320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J0916_02325	COG1376	ErfK ybiS ycfS ynhG family protein
J0916_02375	COG0714	Associated with various cellular activities
J0916_02380	COG0084	hydrolase, TatD family'
J0916_02390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J0916_02395	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J0916_02400	COG0488	(ABC) transporter
J0916_02415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J0916_02425	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J0916_02430	COG0193	aminoacyl-tRNA hydrolase activity
J0916_02450	COG0529	Catalyzes the synthesis of activated sulfate
J0916_02455	COG0730	response to heat
J0916_02475	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J0916_02485	COG0175	sulfate reduction
J0916_02540	COG0822	iron-sulfur transferase activity
J0916_02550	COG5002	protein histidine kinase activity
J0916_02555	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J0916_02560	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J0916_02580	COG5002	protein histidine kinase activity
J0916_02600	COG3979	chitinase
J0916_02615	COG0745	RESPONSE REGULATOR receiver
J0916_02620	COG5002	protein histidine kinase activity
J0916_02630	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
J0916_02645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J0916_02660	COG0733	neurotransmitter:sodium symporter activity
J0916_02665	COG0477	Major facilitator Superfamily
J0916_02710	COG2197	response regulator
J0916_02715	COG4770	biotin carboxylase activity
J0916_02730	COG0424	maF-like protein
J0916_02735	COG0477	Major facilitator Superfamily
J0916_02765	COG2409	Drug exporters of the RND superfamily
J0916_02775	COG1823	symporter activity
J0916_02780	COG1024	Enoyl-CoA hydratase
J0916_02790	COG0765	amino acid transport
J0916_02800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J0916_02810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J0916_02830	COG1176	ABC-type spermidine putrescine transport system, permease component I
J0916_02835	COG3842	ATPase activity
J0916_02860	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_02880	COG1960	acyl-CoA dehydrogenase activity
J0916_02885	COG2086	electron transfer activity
J0916_02890	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
J0916_02920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J0916_02945	COG0631	protein serine/threonine phosphatase activity
J0916_02965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J0916_02990	COG1175	transmembrane transport
J0916_03010	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J0916_03015	COG0154	amidase activity
J0916_03020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J0916_03025	COG0583	DNA-binding transcription factor activity
J0916_03030	COG1063	alcohol dehydrogenase
J0916_03045	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J0916_03060	COG1228	amidohydrolase
J0916_03100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J0916_03105	COG0583	DNA-binding transcription factor activity
J0916_03110	COG1012	belongs to the aldehyde dehydrogenase family
J0916_03130	COG0251	oxidation-reduction process
J0916_03140	COG2837	iron assimilation
J0916_03145	COG2822	iron ion transport
J0916_03150	COG0672	)-iron permease
J0916_03155	COG0588	phosphoglycerate mutase activity
J0916_03170	COG2183	response to ionizing radiation
J0916_03180	COG1302	Protein conserved in bacteria
J0916_03205	COG2873	o-acetylhomoserine
J0916_03210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J0916_03240	COG0423	glycine-tRNA ligase activity
J0916_03255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J0916_03270	COG3424	synthase
J0916_03275	COG2124	cytochrome p450
J0916_03285	COG2986	histidine ammonia-lyase
J0916_03300	COG1126	abc transporter atp-binding protein
J0916_03305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J0916_03315	COG2239	Acts as a magnesium transporter
J0916_03320	COG1309	transcriptional regulator
J0916_03345	COG0358	DNA primase activity
J0916_03375	COG2814	Major facilitator Superfamily
J0916_03410	COG1960	acyl-CoA dehydrogenase activity
J0916_03420	COG0052	Belongs to the universal ribosomal protein uS2 family
J0916_03425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J0916_03430	COG0528	UMP kinase activity
J0916_03435	COG0233	cytoplasmic translational termination
J0916_03455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J0916_03465	COG3279	Response regulator of the LytR AlgR family
J0916_03475	COG3275	phosphorelay sensor kinase activity
J0916_03485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J0916_03510	COG0022	dehydrogenase e1 component
J0916_03515	COG0508	dehydrogenase complex catalyzes the overall conversion of
J0916_03520	COG1309	transcriptional regulator
J0916_03525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J0916_03535	COG1960	acyl-CoA dehydrogenase activity
J0916_03575	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J0916_03580	COG0750	zinc metalloprotease
J0916_03600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J0916_03615	COG0477	Major facilitator Superfamily
J0916_03620	COG0446	pyridine nucleotide-disulphide oxidoreductase
J0916_03620	COG1902	pentaerythritol trinitrate reductase activity
J0916_03635	COG1131	(ABC) transporter
J0916_03640	COG0442	prolyl-tRNA aminoacylation
J0916_03665	COG0779	Required for maturation of 30S ribosomal subunits
J0916_03685	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J0916_03705	COG0196	riboflavin kinase activity
J0916_03710	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J0916_03715	COG1185	polyribonucleotide nucleotidyltransferase activity
J0916_03720	COG0612	Peptidase, M16
J0916_03740	COG0521	Mo-molybdopterin cofactor biosynthetic process
J0916_03740	COG0315	cyclic pyranopterin monophosphate synthase activity
J0916_03750	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J0916_03765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J0916_03770	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
J0916_03775	COG1674	ftsk spoiiie
J0916_03785	COG1058	Belongs to the CinA family
J0916_03785	COG1546	Belongs to the CinA family
J0916_03805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J0916_03810	COG2137	regulation of response to DNA damage stimulus
J0916_03820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J0916_03825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J0916_03830	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J0916_03835	COG2813	Specifically methylates the guanine in position
J0916_03840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J0916_03850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J0916_03865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J0916_03870	COG0131	Imidazoleglycerol-phosphate dehydratase
J0916_03885	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J0916_03910	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J0916_03915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J0916_03920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J0916_03930	COG2814	Major facilitator Superfamily
J0916_03950	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_03960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J0916_03965	COG0072	phenylalanine-tRNA ligase activity
J0916_03965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J0916_04055	COG1597	lipid kinase activity
J0916_04060	COG3237	CsbD-like
J0916_04065	COG0640	Transcriptional regulator
J0916_04090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J0916_04115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J0916_04120	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J0916_04125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J0916_04130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J0916_04135	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J0916_04140	COG1438	arginine binding
J0916_04145	COG0137	argininosuccinate synthase activity
J0916_04150	COG0165	Argininosuccinate lyase
J0916_04175	COG2094	Belongs to the DNA glycosylase MPG family
J0916_04180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J0916_04190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J0916_04225	COG0647	UMP catabolic process
J0916_04240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J0916_04245	COG0497	DNA recombination
J0916_04250	COG0504	CTP synthase activity
J0916_04300	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
J0916_04305	COG2079	MmgE PrpD family protein
J0916_04310	COG2186	Transcriptional regulator
J0916_04335	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J0916_04340	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J0916_04365	COG1160	GTP binding
J0916_04395	COG1960	acyl-CoA dehydrogenase activity
J0916_04415	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J0916_04420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J0916_04430	COG0509	glycine decarboxylation via glycine cleavage system
J0916_04435	COG1716	ATPase activity
J0916_04460	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J0916_04460	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J0916_04475	COG1940	carbohydrate kinase activity
J0916_04490	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
J0916_04495	COG0515	serine threonine protein kinase
J0916_04495	COG2815	serine threonine protein kinase
J0916_04500	COG3942	CHAP domain
J0916_04500	COG1388	LysM domain
J0916_04515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J0916_04525	COG2001	Belongs to the MraZ family
J0916_04530	COG0275	rRNA processing
J0916_04535	COG0768	penicillin binding
J0916_04540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J0916_04555	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J0916_04565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J0916_04580	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J0916_04590	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J0916_04595	COG1799	cell septum assembly
J0916_04610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J0916_04620	COG0587	DNA-directed DNA polymerase activity
J0916_04630	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J0916_04635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J0916_04655	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J0916_04660	COG0174	glutamine synthetase
J0916_04665	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J0916_04675	COG0765	amino acid transport
J0916_04680	COG1126	abc transporter atp-binding protein
J0916_04685	COG2066	Belongs to the glutaminase family
J0916_04705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J0916_04715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J0916_04720	COG0321	lipoyl(octanoyl) transferase activity
J0916_04745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J0916_04750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J0916_04765	COG2223	nitrite transmembrane transporter activity
J0916_04785	COG0187	DNA topoisomerase II activity
J0916_04790	COG0501	Belongs to the peptidase M48B family
J0916_04800	COG1271	oxidase subunit
J0916_04805	COG1294	oxidase, subunit
J0916_04810	COG4988	ABC transporter
J0916_04820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J0916_04855	COG0756	dUTP diphosphatase activity
J0916_04880	COG0569	domain protein
J0916_04885	COG0531	amino acid
J0916_04890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J0916_04900	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J0916_04905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J0916_04920	COG0667	Aldo Keto reductase
J0916_04925	COG3345	alpha-galactosidase
J0916_04935	COG1250	3-hydroxyacyl-CoA dehydrogenase
J0916_04935	COG1024	Enoyl-CoA hydratase
J0916_04940	COG0183	Belongs to the thiolase family
J0916_04945	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
J0916_04970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J0916_04985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J0916_05060	COG0242	peptide deformylase activity
J0916_05065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J0916_05075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J0916_05100	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J0916_05105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J0916_05110	COG0140	phosphoribosyl-ATP diphosphatase activity
J0916_05115	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J0916_05120	COG0107	imidazoleglycerol-phosphate synthase activity
J0916_05130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J0916_05150	COG0134	indole-3-glycerol-phosphate synthase activity
J0916_05155	COG0133	tryptophan synthase activity
J0916_05160	COG0159	tryptophan synthase activity
J0916_05165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J0916_05170	COG0067	glutamate synthase
J0916_05170	COG0069	glutamate synthase activity
J0916_05170	COG0070	glutamate synthase
J0916_05200	COG0582	viral genome integration into host DNA
J0916_05205	COG0582	viral genome integration into host DNA
J0916_05210	COG4974	Belongs to the 'phage' integrase family
J0916_05270	COG0583	DNA-binding transcription factor activity
J0916_05280	COG1012	belongs to the aldehyde dehydrogenase family
J0916_05300	COG1597	lipid kinase activity
J0916_05305	COG0671	phosphoesterase, PA-phosphatase related
J0916_05325	COG1191	sigma factor activity
J0916_05335	COG2197	response regulator
J0916_05380	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_05460	COG2801	Transposase and inactivated derivatives
J0916_05510	COG2132	Multicopper oxidase
J0916_05530	COG2217	Heavy metal translocating P-type atpase
J0916_05540	COG3237	CsbD-like
J0916_05555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J0916_05575	COG0071	Belongs to the small heat shock protein (HSP20) family
J0916_05580	COG0789	Transcriptional regulator
J0916_05600	COG0028	Belongs to the TPP enzyme family
J0916_05605	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J0916_05620	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_05630	COG2017	converts alpha-aldose to the beta-anomer
J0916_05710	COG2197	response regulator
J0916_05770	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J0916_05790	COG2205	protein histidine kinase activity
J0916_05795	COG0745	RESPONSE REGULATOR receiver
J0916_05805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J0916_05830	COG2801	Transposase and inactivated derivatives
J0916_05835	COG0745	RESPONSE REGULATOR receiver
J0916_05840	COG5002	protein histidine kinase activity
J0916_05850	COG2132	Multicopper oxidase
J0916_05850	COG2132	Multicopper oxidase
J0916_05890	COG3511	phospholipase C
J0916_05910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J0916_05910	COG0426	domain, Protein
J0916_05915	COG1063	alcohol dehydrogenase
J0916_05925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J0916_05925	COG0574	Belongs to the PEP-utilizing enzyme family
J0916_05935	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
J0916_05940	COG0589	response to stress
J0916_05965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J0916_05975	COG0069	glutamate synthase activity
J0916_06015	COG0166	Belongs to the GPI family
J0916_06020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
J0916_06040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J0916_06045	COG1053	succinate dehydrogenase
J0916_06065	COG0477	Major facilitator Superfamily
J0916_06070	COG3959	Transketolase, thiamine diphosphate binding domain
J0916_06085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J0916_06085	COG1017	nitric oxide dioxygenase activity
J0916_06100	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J0916_06110	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
J0916_06115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J0916_06120	COG4948	Mandelate Racemase Muconate Lactonizing
J0916_06125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J0916_06130	COG2186	Transcriptional regulator
J0916_06135	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
J0916_06145	COG5002	protein histidine kinase activity
J0916_06150	COG0745	RESPONSE REGULATOR receiver
J0916_06180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J0916_06190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
J0916_06195	COG1854	S-ribosylhomocysteine lyase activity
J0916_06220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J0916_06225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J0916_06290	COG1695	Transcriptional regulator
J0916_06295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J0916_06305	COG1121	(ABC) transporter
J0916_06310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J0916_06325	COG3119	arylsulfatase activity
J0916_06345	COG1940	carbohydrate kinase activity
J0916_06370	COG2268	Band 7 protein
J0916_06395	COG1643	Atp-dependent helicase
J0916_06410	COG0783	Belongs to the Dps family
J0916_06415	COG0009	L-threonylcarbamoyladenylate synthase
J0916_06470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J0916_06480	COG1116	anion transmembrane transporter activity
J0916_06510	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
J0916_06520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J0916_06530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J0916_06535	COG0242	peptide deformylase activity
J0916_06540	COG2226	methyltransferase
J0916_06565	COG1216	Glycosyl transferase, family 2
J0916_06570	COG1574	metal-dependent hydrolase with the TIM-barrel fold
J0916_06575	COG4581	dead DEAH box helicase
J0916_06580	COG0805	protein transport
J0916_06585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J0916_06600	COG0545	Peptidyl-prolyl cis-trans isomerase
J0916_06605	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
J0916_06610	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
J0916_06615	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
J0916_06625	COG4122	O-methyltransferase activity
J0916_06630	COG1222	aaa ATPase
J0916_06645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J0916_06655	COG0215	cysteine-tRNA ligase activity
J0916_06660	COG1968	undecaprenyl-diphosphatase activity
J0916_06665	COG0667	Aldo Keto reductase
J0916_06685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J0916_06705	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_06710	COG0183	Belongs to the thiolase family
J0916_06735	COG0297	glycogen (starch) synthase activity
J0916_06750	COG2855	membrane
J0916_06765	COG0095	Lipoate-protein ligase
J0916_06770	COG0254	rRNA binding
J0916_06790	COG1119	ATPase activity
J0916_06795	COG0560	Phosphoserine phosphatase
J0916_06795	COG3830	Belongs to the UPF0237 family
J0916_06800	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_06805	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_06830	COG0488	(ABC) transporter
J0916_06835	COG1268	BioY protein
J0916_06840	COG1122	ATPase activity
J0916_06855	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_06865	COG2151	metal-sulfur cluster biosynthetic enzyme
J0916_06870	COG0396	ATPase activity
J0916_06890	COG1131	(ABC) transporter
J0916_06900	COG1612	heme a metabolic process
J0916_06910	COG0109	protoheme IX farnesyltransferase activity
J0916_06920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J0916_06925	COG0166	Belongs to the GPI family
J0916_06940	COG0363	glucosamine-6-phosphate deaminase activity
J0916_06945	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J0916_06950	COG0149	triose-phosphate isomerase activity
J0916_06955	COG0126	phosphoglycerate kinase activity
J0916_06960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J0916_06965	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J0916_06970	COG0391	Required for morphogenesis under gluconeogenic growth conditions
J0916_06975	COG1660	Displays ATPase and GTPase activities
J0916_06980	COG0322	excinuclease ABC activity
J0916_06985	COG0204	Acyl-transferase
J0916_06985	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_07020	COG4106	trans-aconitate 2-methyltransferase activity
J0916_07040	COG0556	nucleotide-excision repair
J0916_07050	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
J0916_07050	COG0237	dephospho-CoA kinase activity
J0916_07055	COG1739	Uncharacterized protein family UPF0029
J0916_07065	COG0539	negative regulation of cytoplasmic translation
J0916_07085	COG2050	protein possibly involved in aromatic compounds catabolism
J0916_07100	COG0436	Aminotransferase
J0916_07110	COG2261	transglycosylase associated protein
J0916_07115	COG1295	ribonuclease BN
J0916_07135	COG0673	inositol 2-dehydrogenase activity
J0916_07150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J0916_07155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J0916_07160	COG3842	ATPase activity
J0916_07175	COG1177	transmembrane transport
J0916_07180	COG1522	sequence-specific DNA binding
J0916_07190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J0916_07195	COG1012	belongs to the aldehyde dehydrogenase family
J0916_07200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J0916_07235	COG0109	protoheme IX farnesyltransferase activity
J0916_07255	COG3142	Participates in the control of copper homeostasis
J0916_07260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J0916_07265	COG1845	cytochrome c oxidase, subunit III
J0916_07270	COG2010	Cytochrome c
J0916_07275	COG0723	plastoquinol--plastocyanin reductase activity
J0916_07280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J0916_07285	COG2188	Transcriptional regulator
J0916_07300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J0916_07305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J0916_07325	COG0667	Aldo Keto reductase
J0916_07330	COG0167	dihydroorotate dehydrogenase activity
J0916_07345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J0916_07350	COG1381	Involved in DNA repair and RecF pathway recombination
J0916_07355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J0916_07360	COG3590	peptidase
J0916_07365	COG1316	TRANSCRIPTIONal
J0916_07370	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J0916_07380	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J0916_07400	COG0484	heat shock protein binding
J0916_07405	COG1420	regulation of RNA biosynthetic process
J0916_07420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J0916_07425	COG0481	GTPase activity
J0916_07435	COG0268	Binds directly to 16S ribosomal RNA
J0916_07455	COG1307	EDD domain protein, DegV family
J0916_07460	COG0495	leucyl-tRNA aminoacylation
J0916_07465	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J0916_07470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J0916_07475	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
J0916_07480	COG2390	Transcriptional regulator
J0916_07535	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J0916_07540	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J0916_07550	COG1758	RNA polymerase activity
J0916_07555	COG0194	GDP metabolic process
J0916_07565	COG0284	orotidine-5'-phosphate decarboxylase activity
J0916_07570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J0916_07575	COG0505	Belongs to the CarA family
J0916_07580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J0916_07585	COG0540	Belongs to the ATCase OTCase family
J0916_07590	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
J0916_07600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J0916_07605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J0916_07615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J0916_07620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J0916_07625	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J0916_07630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J0916_07640	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J0916_07645	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J0916_07660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J0916_07675	COG0531	amino acid
J0916_07680	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J0916_07685	COG0124	histidyl-tRNA synthetase
J0916_07695	COG1196	nuclear chromosome segregation
J0916_07700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J0916_07705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J0916_07710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J0916_07720	COG2255	four-way junction helicase activity
J0916_07725	COG0632	four-way junction helicase activity
J0916_07730	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J0916_07735	COG0217	transcriptional regulatory protein
J0916_07740	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
J0916_07745	COG0367	asparagine synthase
J0916_07760	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
J0916_07765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J0916_07775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J0916_07780	COG0587	DNA-directed DNA polymerase activity
J0916_07785	COG0456	acetyltransferase
J0916_07795	COG2135	peptidase activity
J0916_07830	COG1196	nuclear chromosome segregation
J0916_07830	COG0741	lytic transglycosylase activity
J0916_07830	COG0739	heme binding
J0916_07835	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_07850	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J0916_07855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J0916_07860	COG1780	Probably involved in ribonucleotide reductase function
J0916_07875	COG1012	belongs to the aldehyde dehydrogenase family
J0916_07900	COG2813	Specifically methylates the guanine in position
J0916_07905	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J0916_07910	COG3012	SEC-C Motif Domain Protein
J0916_07915	COG2188	Transcriptional regulator
J0916_07935	COG0799	negative regulation of ribosome biogenesis
J0916_07945	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J0916_07950	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J0916_07955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J0916_07960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J0916_07965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J0916_07970	COG0351	phosphomethylpyrimidine kinase
J0916_07970	COG0352	thiamine-phosphate diphosphorylase activity
J0916_07970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
J0916_07975	COG1530	ribonuclease E activity
J0916_07990	COG0105	UTP biosynthetic process
J0916_08000	COG0285	dihydrofolate synthase activity
J0916_08005	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J0916_08015	COG2271	Major facilitator Superfamily
J0916_08020	COG1802	Transcriptional regulator
J0916_08040	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
J0916_08050	COG0583	DNA-binding transcription factor activity
J0916_08055	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
J0916_08060	COG0829	nickel cation binding
J0916_08065	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
J0916_08070	COG0830	nickel cation binding
J0916_08075	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
J0916_08080	COG0804	urea catabolic process
J0916_08085	COG0832	Belongs to the urease beta subunit family
J0916_08090	COG0831	urea catabolic process
J0916_08110	COG2271	Major facilitator Superfamily
J0916_08120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J0916_08130	COG1960	acyl-CoA dehydrogenase activity
J0916_08135	COG3189	MarR family transcriptional regulator
J0916_08145	COG0525	valine-tRNA ligase activity
J0916_08150	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J0916_08155	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J0916_08160	COG0740	serine-type endopeptidase activity
J0916_08165	COG0740	serine-type endopeptidase activity
J0916_08170	COG0544	peptidyl-prolyl cis-trans isomerase activity
J0916_08190	COG0698	ribose 5-phosphate isomerase
J0916_08215	COG0668	transmembrane transport
J0916_08220	COG2346	COG2346, Truncated hemoglobins
J0916_08235	COG1946	Acyl-CoA thioesterase
J0916_08250	COG0629	single-stranded DNA binding
J0916_08265	COG0531	amino acid
J0916_08275	COG1012	belongs to the aldehyde dehydrogenase family
J0916_08300	COG1960	acyl-CoA dehydrogenase activity
J0916_08305	COG1012	belongs to the aldehyde dehydrogenase family
J0916_08310	COG0473	3-isopropylmalate dehydrogenase activity
J0916_08340	COG0076	glutamate decarboxylase activity
J0916_08345	COG2890	protein-(glutamine-N5) methyltransferase activity
J0916_08385	COG0242	peptide deformylase activity
J0916_08395	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J0916_08420	COG1484	DNA-dependent DNA replication
J0916_08455	COG3022	response to hydroperoxide
J0916_08470	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
J0916_08475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J0916_08485	COG1045	serine acetyltransferase
J0916_08490	COG0024	Methionine aminopeptidase
J0916_08495	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
J0916_08505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J0916_08530	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
J0916_08545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J0916_08550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J0916_08555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J0916_08565	COG4974	Belongs to the 'phage' integrase family
J0916_08570	COG1316	TRANSCRIPTIONal
J0916_08585	COG0792	nuclease activity
J0916_08595	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J0916_08605	COG0681	Belongs to the peptidase S26 family
J0916_08610	COG0335	large ribosomal subunit rRNA binding
J0916_08615	COG0336	Belongs to the RNA methyltransferase TrmD family
J0916_08620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J0916_08625	COG1837	Belongs to the UPF0109 family
J0916_08630	COG0228	four-way junction DNA binding
J0916_08645	COG4172	Belongs to the ABC transporter superfamily
J0916_08670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J0916_08715	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_08720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J0916_08725	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J0916_08730	COG0571	ribonuclease III activity
J0916_08735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J0916_08745	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J0916_08750	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_08770	COG0673	inositol 2-dehydrogenase activity
J0916_08780	COG2268	Band 7 protein
J0916_08800	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J0916_08805	COG3483	tryptophan 2,3-dioxygenase activity
J0916_08825	COG0742	ribosomal rna small subunit methyltransferase
J0916_08835	COG1461	Dihydroxyacetone kinase
J0916_08855	COG3345	alpha-galactosidase
J0916_08865	COG0395	ABC-type sugar transport system, permease component
J0916_08870	COG1175	transmembrane transport
J0916_08890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J0916_08895	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J0916_08910	COG2826	transposase and inactivated derivatives, IS30 family
J0916_08920	COG1484	DNA-dependent DNA replication
J0916_08930	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
J0916_08930	COG1215	transferase activity, transferring glycosyl groups
J0916_08935	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
J0916_08945	COG1388	LysM domain
J0916_08945	COG1134	teichoic acid transport
J0916_08955	COG0438	transferase activity, transferring glycosyl groups
J0916_08975	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
J0916_08975	COG0463	Glycosyl transferase, family 2
J0916_08980	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
J0916_09020	COG1316	TRANSCRIPTIONal
J0916_09030	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
J0916_09040	COG1181	Belongs to the D-alanine--D-alanine ligase family
J0916_09045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J0916_09055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J0916_09060	COG1132	(ABC) transporter
J0916_09070	COG0066	3-isopropylmalate dehydratase activity
J0916_09075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J0916_09080	COG1414	Transcriptional regulator
J0916_09115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J0916_09125	COG2197	response regulator
J0916_09130	COG4585	Histidine kinase
J0916_09135	COG0179	Fumarylacetoacetate (FAA) hydrolase
J0916_09140	COG2116	formate transmembrane transporter activity
J0916_09150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J0916_09155	COG0473	3-isopropylmalate dehydrogenase activity
J0916_09160	COG0415	Belongs to the DNA photolyase family
J0916_09195	COG0702	epimerase
J0916_09200	COG4585	Histidine kinase
J0916_09205	COG2197	response regulator
J0916_09215	COG1175	transmembrane transport
J0916_09225	COG2188	Transcriptional regulator
J0916_09230	COG0577	efflux transmembrane transporter activity
J0916_09230	COG1136	(ABC) transporter
J0916_09250	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J0916_09255	COG0440	acetolactate synthase activity
J0916_09260	COG0028	Belongs to the TPP enzyme family
J0916_09265	COG0129	dihydroxy-acid dehydratase activity
J0916_09280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J0916_09295	COG0747	negative chemotaxis
J0916_09300	COG0579	oxidoreductase
J0916_09305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J0916_09315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J0916_09335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J0916_09355	COG2205	protein histidine kinase activity
J0916_09385	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
J0916_09390	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
J0916_09400	COG1113	amino acid transport
J0916_09415	COG0419	ATPase involved in DNA repair
J0916_09420	COG0420	3'-5' exonuclease activity
J0916_09440	COG2149	membrane
J0916_09460	COG0586	Pfam SNARE associated Golgi protein
J0916_09465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J0916_09470	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J0916_09480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J0916_09490	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
J0916_09495	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
J0916_09500	COG1335	isochorismatase
J0916_09515	COG0363	glucosamine-6-phosphate deaminase activity
J0916_09530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J0916_09535	COG0628	permease
J0916_09555	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
J0916_09560	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J0916_09570	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J0916_09575	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
J0916_09585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J0916_09590	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J0916_09595	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J0916_09600	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J0916_09605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J0916_09610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J0916_09615	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J0916_09620	COG0356	it plays a direct role in the translocation of protons across the membrane
J0916_09630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J0916_09655	COG2890	protein-(glutamine-N5) methyltransferase activity
J0916_09660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J0916_09670	COG0083	homoserine kinase activity
J0916_09675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
J0916_09685	COG0019	diaminopimelate decarboxylase activity
J0916_09690	COG0018	arginyl-trna synthetase
J0916_09720	COG2211	Major facilitator Superfamily
J0916_09725	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J0916_09750	COG1643	Atp-dependent helicase
J0916_09755	COG1643	Atp-dependent helicase
J0916_09760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J0916_09765	COG0537	adenosine 5'-monophosphoramidase activity
J0916_09775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J0916_09800	COG3842	ATPase activity
J0916_09815	COG1253	flavin adenine dinucleotide binding
J0916_09830	COG3265	gluconokinase activity
J0916_09835	COG0246	Mannitol dehydrogenase
J0916_09840	COG2186	Transcriptional regulator
J0916_09845	COG1063	alcohol dehydrogenase
J0916_09855	COG1175	transmembrane transport
J0916_09865	COG4948	Mandelate Racemase Muconate Lactonizing
J0916_09875	COG0508	dehydrogenase complex catalyzes the overall conversion of
J0916_09875	COG0567	Dehydrogenase, E1 component
J0916_09890	COG1595	DNA-templated transcription, initiation
J0916_09900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J0916_09910	COG0483	inositol monophosphate 1-phosphatase activity
J0916_09930	COG1321	iron dependent repressor
J0916_09935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J0916_09960	COG1472	Belongs to the glycosyl hydrolase 3 family
J0916_09965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J0916_09975	COG2177	Part of the ABC transporter FtsEX involved in
J0916_09980	COG2884	Cell division ATP-binding protein ftsE
J0916_09985	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
J0916_10045	COG1132	(ABC) transporter
J0916_10070	COG0673	inositol 2-dehydrogenase activity
J0916_10080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J0916_10090	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J0916_10100	COG1088	dTDP-glucose 4,6-dehydratase activity
J0916_10105	COG0463	Glycosyl transferase, family 2
J0916_10110	COG1216	Glycosyl transferase, family 2
J0916_10120	COG0463	Glycosyl transferase, family 2
J0916_10120	COG1216	Glycosyl transferase, family 2
J0916_10130	COG2755	lipolytic protein G-D-S-L family
J0916_10130	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J0916_10140	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
J0916_10155	COG1216	Glycosyl transferase, family 2
J0916_10170	COG1674	ftsk spoiiie
J0916_10185	COG2902	Dehydrogenase
J0916_10205	COG0653	protein targeting
J0916_10215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
J0916_10220	COG1040	competence protein
J0916_10225	COG5401	PFAM Sporulation and spore germination
J0916_10230	COG5002	protein histidine kinase activity
J0916_10230	COG5000	phosphorelay sensor kinase activity
J0916_10235	COG0745	RESPONSE REGULATOR receiver
J0916_10250	COG0714	Associated with various cellular activities
J0916_10270	COG4172	Belongs to the ABC transporter superfamily
J0916_10275	COG4171	peptide transport system, permease
J0916_10280	COG0601	transmembrane transport
J0916_10295	COG0482	sulfurtransferase activity
J0916_10305	COG0302	gtp cyclohydrolase
J0916_10315	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J0916_10325	COG1597	lipid kinase activity
J0916_10330	COG0484	heat shock protein binding
J0916_10335	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J0916_10345	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
J0916_10350	COG2086	electron transfer activity
J0916_10355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J0916_10365	COG1842	Phage shock protein A
J0916_10380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J0916_10385	COG0531	amino acid
J0916_10390	COG1309	transcriptional regulator
J0916_10395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
J0916_10400	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_10405	COG0183	Belongs to the thiolase family
J0916_10415	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_10420	COG1024	Enoyl-CoA hydratase
J0916_10425	COG1960	acyl-CoA dehydrogenase activity
J0916_10455	COG0640	Transcriptional regulator
J0916_10475	COG2161	toxin-antitoxin pair type II binding
J0916_10495	COG0542	response to heat
J0916_10500	COG0542	response to heat
J0916_10505	COG1475	DNA binding
J0916_10515	COG1131	(ABC) transporter
J0916_10540	COG1280	lysine exporter protein (LysE YggA)
J0916_10560	COG0384	phenazine biosynthesis protein PhzF
J0916_10575	COG2826	transposase and inactivated derivatives, IS30 family
J0916_10590	COG3585	molybdate ion transport
J0916_10615	COG1902	pentaerythritol trinitrate reductase activity
J0916_10620	COG1024	Enoyl-CoA hydratase
J0916_10630	COG1024	Enoyl-CoA hydratase
J0916_10635	COG1960	acyl-CoA dehydrogenase activity
J0916_10645	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
J0916_10650	COG2086	electron transfer activity
J0916_10655	COG1846	Transcriptional regulator
J0916_10660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J0916_10665	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_10670	COG1024	Enoyl-CoA hydratase
J0916_10680	COG0183	Belongs to the thiolase family
J0916_10690	COG1024	Enoyl-CoA hydratase
J0916_10700	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_10705	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_10710	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_10730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J0916_10750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J0916_10760	COG1615	UPF0182 protein
J0916_10765	COG3480	Lon protease (S16) C-terminal proteolytic domain
J0916_10805	COG0210	DNA helicase
J0916_10825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J0916_10830	COG0765	amino acid transport
J0916_10835	COG1126	abc transporter atp-binding protein
J0916_10850	COG0463	Glycosyl transferase, family 2
J0916_10855	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J0916_10865	COG0181	hydroxymethylbilane synthase activity
J0916_10870	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J0916_10885	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J0916_10890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J0916_10920	COG2154	pterin-4-alpha-carbinolamine dehydratase
J0916_10925	COG2022	thiamine diphosphate biosynthetic process
J0916_10935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J0916_10935	COG2022	thiamine diphosphate biosynthetic process
J0916_10940	COG0352	thiamine-phosphate diphosphorylase activity
J0916_10955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J0916_10960	COG2072	flavoprotein involved in K transport
J0916_10980	COG0515	serine threonine protein kinase
J0916_10985	COG1674	ftsk spoiiie
J0916_10985	COG0433	COG0433 Predicted ATPase
J0916_11030	COG2271	Major facilitator Superfamily
J0916_11040	COG1012	belongs to the aldehyde dehydrogenase family
J0916_11045	COG0583	DNA-binding transcription factor activity
J0916_11060	COG2814	Major facilitator Superfamily
J0916_11065	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J0916_11085	COG0513	Belongs to the DEAD box helicase family
J0916_11100	COG0006	proline dipeptidase activity
J0916_11115	COG2239	Acts as a magnesium transporter
J0916_11130	COG1595	DNA-templated transcription, initiation
J0916_11150	COG0519	Catalyzes the synthesis of GMP from XMP
J0916_11165	COG1126	abc transporter atp-binding protein
J0916_11170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J0916_11175	COG0765	amino acid transport
J0916_11180	COG0765	amino acid transport
J0916_11185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J0916_11210	COG2171	N-acyltransferase activity
J0916_11250	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J0916_11260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J0916_11265	COG0601	transmembrane transport
J0916_11270	COG4166	transmembrane transport
J0916_11275	COG1217	gtp-binding protein TYPA
J0916_11290	COG1231	oxidoreductase activity
J0916_11330	COG0012	GTP binding
J0916_11335	COG1322	Protein conserved in bacteria
J0916_11340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J0916_11345	COG1570	exodeoxyribonuclease VII activity
J0916_11350	COG1722	exodeoxyribonuclease VII activity
J0916_11360	COG2326	polyphosphate kinase activity
J0916_11375	COG1609	Transcriptional regulator
J0916_11380	COG2971	BadF BadG BcrA BcrD
J0916_11385	COG2070	2-Nitropropane dioxygenase
J0916_11395	COG0598	Magnesium transport protein CorA
J0916_11400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J0916_11405	COG0778	Nitroreductase
J0916_11415	COG0039	L-malate dehydrogenase activity
J0916_11420	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
J0916_11425	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
J0916_11440	COG1309	transcriptional regulator
J0916_11445	COG1131	(ABC) transporter
J0916_11470	COG1846	Transcriptional regulator
J0916_11475	COG2409	Drug exporters of the RND superfamily
J0916_11480	COG0488	(ABC) transporter
J0916_11510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J0916_11525	COG0477	Major facilitator Superfamily
J0916_11540	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J0916_11565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J0916_11570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J0916_11575	COG3711	transcriptional antiterminator
J0916_11580	COG2190	(PTS) system
J0916_11580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J0916_11580	COG1263	PTS System
J0916_11585	COG1263	PTS System
J0916_11585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J0916_11585	COG2190	(PTS) system
J0916_11595	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
J0916_11605	COG1846	Transcriptional regulator
J0916_11610	COG1764	response to oxidative stress
J0916_11635	COG0783	Belongs to the Dps family
J0916_11745	COG3386	PFAM SMP-30 Gluconolaconase
J0916_11760	COG1175	transmembrane transport
J0916_11765	COG0395	ABC-type sugar transport system, permease component
J0916_11790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J0916_11815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J0916_11815	COG0519	Catalyzes the synthesis of GMP from XMP
J0916_11835	COG0516	GMP reductase activity
J0916_11855	COG2217	Heavy metal translocating P-type atpase
J0916_11860	COG0459	protein refolding
J0916_11865	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J0916_11870	COG1131	(ABC) transporter
J0916_11905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J0916_11910	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
J0916_11950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J0916_11955	COG0456	acetyltransferase
J0916_11965	COG0802	atpase or kinase
J0916_11970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J0916_11975	COG0438	transferase activity, transferring glycosyl groups
J0916_11990	COG0366	Alpha amylase catalytic
J0916_12000	COG1260	myo-inositol-1-phosphate synthase
J0916_12005	COG0667	Aldo Keto reductase
J0916_12020	COG0736	holo-[acyl-carrier-protein] synthase activity
J0916_12030	COG1072	(Pantothenic acid kinase))
J0916_12040	COG1970	mechanosensitive ion channel activity
J0916_12045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J0916_12050	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J0916_12055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J0916_12060	COG0101	tRNA pseudouridine synthase activity
J0916_12070	COG0203	ribosomal protein L17
J0916_12075	COG0202	RNA polymerase activity
J0916_12080	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J0916_12085	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J0916_12090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J0916_12095	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J0916_12115	COG0395	ABC-type sugar transport system, permease component
J0916_12130	COG0024	Methionine aminopeptidase
J0916_12145	COG0200	Binds to the 23S rRNA
J0916_12155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J0916_12165	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J0916_12170	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J0916_12175	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J0916_12185	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J0916_12190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J0916_12195	COG0255	Belongs to the universal ribosomal protein uL29 family
J0916_12200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J0916_12205	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J0916_12210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J0916_12215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J0916_12220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J0916_12225	COG0089	rRNA binding
J0916_12230	COG0088	Forms part of the polypeptide exit tunnel
J0916_12235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J0916_12240	COG0051	transcription antitermination factor activity, RNA binding
J0916_12250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J0916_12255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J0916_12260	COG0049	tRNA binding
J0916_12265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J0916_12270	COG1752	Esterase of the alpha-beta hydrolase superfamily
J0916_12275	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J0916_12280	COG0085	RNA polymerase activity
J0916_12285	COG0183	Belongs to the thiolase family
J0916_12290	COG0442	prolyl-tRNA aminoacylation
J0916_12295	COG0222	ribosome binding
J0916_12300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J0916_12315	COG0081	regulation of translation
J0916_12320	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J0916_12325	COG0250	Participates in transcription elongation, termination and antitermination
J0916_12340	COG0436	Aminotransferase
J0916_12345	COG2197	response regulator
J0916_12385	COG3485	protocatechuate 3,4-dioxygenase
J0916_12390	COG0745	RESPONSE REGULATOR receiver
J0916_12395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J0916_12400	COG0456	acetyltransferase
J0916_12405	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J0916_12410	COG0406	alpha-ribazole phosphatase activity
J0916_12410	COG0494	nUDIX hydrolase
J0916_12420	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J0916_12425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
J0916_12435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J0916_12450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J0916_12455	COG2223	nitrite transmembrane transporter activity
J0916_12465	COG2030	dehydratase
J0916_12475	COG0477	Major facilitator Superfamily
J0916_12485	COG2301	Belongs to the HpcH HpaI aldolase family
J0916_12520	COG0477	Major facilitator Superfamily
J0916_12540	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
J0916_12550	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
J0916_12560	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_12565	COG0402	S-adenosylhomocysteine deaminase activity
J0916_12570	COG1652	LysM domain
J0916_12600	COG1012	belongs to the aldehyde dehydrogenase family
J0916_12605	COG0583	DNA-binding transcription factor activity
J0916_12610	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
J0916_12615	COG3655	Transcriptional regulator
J0916_12630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J0916_12635	COG2814	Major facilitator Superfamily
J0916_12655	COG1666	GTP binding
J0916_12670	COG4585	Histidine kinase
J0916_12675	COG0406	alpha-ribazole phosphatase activity
J0916_12685	COG0753	catalase activity
J0916_12730	COG1876	peptidase activity
J0916_12755	COG1648	precorrin-2 dehydrogenase activity
J0916_12755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J0916_12760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J0916_12805	COG0175	sulfate reduction
J0916_12810	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J0916_12820	COG0508	dehydrogenase complex catalyzes the overall conversion of
J0916_12825	COG0508	dehydrogenase complex catalyzes the overall conversion of
J0916_12825	COG0022	dehydrogenase e1 component
J0916_12830	COG0022	dehydrogenase e1 component
J0916_12830	COG0508	dehydrogenase complex catalyzes the overall conversion of
J0916_12835	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J0916_12840	COG0517	IMP dehydrogenase activity
J0916_12845	COG0477	Major facilitator Superfamily
J0916_12865	COG4152	abc transporter atp-binding protein
J0916_12870	COG2860	membrane
J0916_12880	COG0142	geranyltranstransferase activity
J0916_12900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J0916_12905	COG0765	amino acid transport
J0916_12915	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
J0916_12920	COG4948	Mandelate Racemase Muconate Lactonizing
J0916_12950	COG0508	dehydrogenase complex catalyzes the overall conversion of
J0916_12990	COG2026	Addiction module toxin, RelE StbE family
J0916_12995	COG2161	toxin-antitoxin pair type II binding
J0916_13015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J0916_13025	COG1619	proteins homologs of microcin C7 resistance protein MccF
J0916_13055	COG3345	alpha-galactosidase
J0916_13085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J0916_13090	COG2151	metal-sulfur cluster biosynthetic enzyme
J0916_13095	COG3396	Phenylacetate-CoA oxygenase
J0916_13105	COG3396	Phenylacetate-CoA oxygenase
J0916_13130	COG1012	belongs to the aldehyde dehydrogenase family
J0916_13130	COG2030	dehydratase
J0916_13135	COG1250	3-hydroxyacyl-CoA dehydrogenase
J0916_13140	COG1024	Enoyl-CoA hydratase
J0916_13155	COG0076	glutamate decarboxylase activity
J0916_13195	COG1472	Belongs to the glycosyl hydrolase 3 family
J0916_13200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J0916_13205	COG0280	phosphate acetyltransferase
J0916_13205	COG0857	belongs to the CobB CobQ family
J0916_13245	COG0653	protein targeting
J0916_13250	COG2365	Tyrosine phosphatase family
J0916_13275	COG0586	Pfam SNARE associated Golgi protein
J0916_13295	COG1131	(ABC) transporter
J0916_13300	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
J0916_13315	COG0745	RESPONSE REGULATOR receiver
J0916_13320	COG0671	phosphoesterase, PA-phosphatase related
J0916_13325	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J0916_13330	COG5479	isomerase activity
J0916_13330	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
J0916_13370	COG2072	flavoprotein involved in K transport
J0916_13380	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
J0916_13415	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
J0916_13445	COG3550	peptidyl-serine autophosphorylation
J0916_13470	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
J0916_13505	COG4942	peptidase
J0916_13550	COG1309	transcriptional regulator
J0916_13585	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J0916_13595	COG0129	dihydroxy-acid dehydratase activity
J0916_13605	COG4555	ABC transporter
J0916_13625	COG2080	2 iron, 2 sulfur cluster binding
J0916_13630	COG0590	tRNA wobble adenosine to inosine editing
J0916_13645	COG1846	Transcriptional regulator
J0916_13660	COG0047	phosphoribosylformylglycinamidine synthase activity
J0916_13665	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J0916_13680	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
J0916_13690	COG1832	CoA-binding protein
J0916_13700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J0916_13705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J0916_13715	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_13750	COG0191	fructose-bisphosphate aldolase activity
J0916_13765	COG0357	Ribosomal RNA small subunit methyltransferase G
J0916_13765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J0916_13775	COG1435	thymidine kinase activity
J0916_13780	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J0916_13790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J0916_13795	COG4176	ABC-type proline glycine betaine transport system permease component
J0916_13800	COG4175	Glycine betaine
J0916_13800	COG3448	diguanylate cyclase activity
J0916_13875	COG2372	response to copper ion
J0916_13880	COG2252	PERMEase
J0916_13885	COG0010	Belongs to the arginase family
J0916_13890	COG2986	histidine ammonia-lyase
J0916_13930	COG4122	O-methyltransferase activity
J0916_13950	COG3387	PFAM Glycoside hydrolase 15-related
J0916_13955	COG0584	glycerophosphoryl diester phosphodiesterase
J0916_13960	COG2733	membrane
J0916_13990	COG0765	amino acid transport
J0916_14000	COG0519	Catalyzes the synthesis of GMP from XMP
J0916_14000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J0916_14015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J0916_14015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J0916_14015	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J0916_14020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J0916_14030	COG0477	Major facilitator Superfamily
J0916_14035	COG0300	oxidoreductase activity
J0916_14045	COG0351	phosphomethylpyrimidine kinase
J0916_14050	COG1335	isochorismatase
J0916_14075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J0916_14090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J0916_14105	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
J0916_14110	COG1194	a g-specific adenine glycosylase
J0916_14115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J0916_14115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J0916_14115	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
J0916_14125	COG2376	Dihydroxyacetone kinase
J0916_14130	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
J0916_14135	COG3548	integral membrane protein
J0916_14150	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J0916_14155	COG1609	Transcriptional regulator
J0916_14165	COG0477	Major facilitator Superfamily
J0916_14170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J0916_14175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J0916_14200	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J0916_14210	COG0302	gtp cyclohydrolase
J0916_14215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J0916_14225	COG0037	tRNA processing
J0916_14245	COG0561	phosphatase activity
J0916_14250	COG0477	Major facilitator Superfamily
J0916_14255	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J0916_14260	COG1597	lipid kinase activity
J0916_14275	COG3104	oligopeptide transport
J0916_14300	COG2233	PERMEase
J0916_14305	COG1929	Belongs to the glycerate kinase type-1 family
J0916_14315	COG0561	phosphatase activity
J0916_14395	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
J0916_14400	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J0916_14405	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J0916_14415	COG1987	bacterial-type flagellum assembly
J0916_14420	COG1338	Plays a role in the flagellum-specific transport system
J0916_14470	COG1157	protein secretion by the type III secretion system
J0916_14475	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
J0916_14480	COG1766	The M ring may be actively involved in energy transduction
J0916_14485	COG1677	Flagellar hook-basal body complex protein FliE
J0916_14510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J0916_14525	COG1256	bacterial-type flagellum assembly
J0916_14525	COG4786	Flagellar basal body rod
J0916_14540	COG1063	alcohol dehydrogenase
J0916_14555	COG1556	Lactate utilization protein
J0916_14560	COG1139	Iron-sulfur cluster binding protein
J0916_14565	COG0247	lactate metabolic process
J0916_14570	COG1522	sequence-specific DNA binding
J0916_14580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
J0916_14610	COG3853	Toxic anion resistance protein (TelA)
J0916_14650	COG0583	DNA-binding transcription factor activity
J0916_14680	COG1362	aminopeptidase activity
J0916_14685	COG2197	response regulator
J0916_14690	COG4585	Histidine kinase
J0916_14705	COG0738	Major facilitator superfamily
J0916_14710	COG0488	(ABC) transporter
J0916_14715	COG0791	NLP P60 protein
J0916_14715	COG3883	PFAM NLP P60 protein
J0916_14730	COG4585	Histidine kinase
J0916_14740	COG1136	(ABC) transporter
J0916_14760	COG0406	alpha-ribazole phosphatase activity
J0916_14765	COG0617	tRNA 3'-terminal CCA addition
J0916_14780	COG0492	ferredoxin-NADP+ reductase activity
J0916_14785	COG3118	belongs to the thioredoxin family
J0916_14830	COG1192	Involved in chromosome partitioning
J0916_14835	COG0357	Ribosomal RNA small subunit methyltransferase G
J0916_14845	COG0706	membrane insertase activity
J0916_14850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J0916_14855	COG0594	ribonuclease P activity
J0916_14860	COG0230	Belongs to the bacterial ribosomal protein bL34 family
J0916_14865	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J0916_14870	COG0592	DNA-directed DNA polymerase activity
J0916_14875	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
J0916_14880	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J0916_14885	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
J0916_14890	COG0187	DNA topoisomerase II activity
J0916_14895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J0916_14900	COG3266	domain, Protein
J0916_14920	COG0705	Rhomboid family
J0916_14980	COG3764	Sortase (surface protein transpeptidase)
J0916_14990	COG0515	serine threonine protein kinase
J0916_14995	COG0515	serine threonine protein kinase
J0916_15020	COG1716	ATPase activity
J0916_15095	COG0360	Binds together with S18 to 16S ribosomal RNA
J0916_15105	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J0916_15110	COG0359	binds to the 23S rRNA
J0916_15115	COG0305	Participates in initiation and elongation during chromosome replication
J0916_15135	COG4821	SIS domain
J0916_15140	COG1653	transport
J0916_15145	COG1175	transmembrane transport
J0916_15150	COG0395	ABC-type sugar transport system, permease component
J0916_15175	COG1937	Protein conserved in bacteria
J0916_15185	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
J0916_15190	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J0916_15205	COG0436	Aminotransferase
J0916_15215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J0916_15230	COG1950	PFAM Membrane protein of
J0916_15235	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J0916_15245	COG0022	dehydrogenase e1 component
J0916_15250	COG0508	dehydrogenase complex catalyzes the overall conversion of
J0916_15255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J0916_15260	COG0686	Belongs to the AlaDH PNT family
J0916_15265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J0916_15275	COG0673	inositol 2-dehydrogenase activity
J0916_15320	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J0916_15325	COG0247	lactate metabolic process
J0916_15325	COG0277	FAD linked oxidase domain protein
J0916_15355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J0916_15370	COG1174	glycine betaine transport
J0916_15380	COG1125	glycine betaine transport
J0916_15380	COG0517	IMP dehydrogenase activity
J0916_15390	COG0435	Glutathione S-transferase
J0916_15395	COG2764	glyoxalase bleomycin resistance protein dioxygenase
J0916_15405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J0916_15410	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J0916_15415	COG1120	ATPase activity
J0916_15430	COG1132	(ABC) transporter
J0916_15440	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J0916_15445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J0916_15450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J0916_15455	COG0776	regulation of translation
J0916_15470	COG0433	COG0433 Predicted ATPase
J0916_15480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J0916_15485	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
J0916_15500	COG3239	Fatty acid desaturase
J0916_15515	COG0475	glutathione-regulated potassium exporter activity
J0916_15525	COG0717	Belongs to the dCTP deaminase family
J0916_15545	COG0651	ATP synthesis coupled electron transport
J0916_15555	COG2212	antiporter activity
J0916_15560	COG1320	monovalent cation:proton antiporter activity
J0916_15570	COG4721	ABC-type cobalt transport system, permease component
J0916_15575	COG1122	ATPase activity
J0916_15585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J0916_15620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J0916_15630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J0916_15640	COG1280	lysine exporter protein (LysE YggA)
J0916_15645	COG0640	Transcriptional regulator
J0916_15650	COG0798	PFAM Bile acid sodium symporter
J0916_15655	COG2226	methyltransferase
J0916_15660	COG0443	Heat shock 70 kDa protein
J0916_15665	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J0916_15670	COG0484	heat shock protein binding
J0916_15675	COG0789	Transcriptional regulator
J0916_15680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J0916_15700	COG1140	nitrate reductase beta subunit
J0916_15710	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J0916_15730	COG3304	Inner membrane component domain
J0916_15740	COG0667	Aldo Keto reductase
J0916_15760	COG2226	methyltransferase
J0916_15770	COG1476	TRANSCRIPTIONal
J0916_15775	COG0542	response to heat
J0916_15785	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J0916_15830	COG0151	Belongs to the GarS family
J0916_15835	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J0916_15845	COG2824	Alkylphosphonate utilization operon protein PhnA
J0916_15860	COG1408	metallophosphoesterase
J0916_15905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J0916_15965	COG1205	dead DEAH box helicase
J0916_15965	COG1111	helicase
J0916_15970	COG1054	Belongs to the UPF0176 family
J0916_15975	COG2890	protein-(glutamine-N5) methyltransferase activity
J0916_15980	COG1285	pathogenesis
J0916_15985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J0916_15985	COG1754	DNA topoisomerase type I activity
J0916_15990	COG0248	Ppx GppA phosphatase
J0916_15995	COG1082	Xylose isomerase domain protein TIM barrel
J0916_16000	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
J0916_16005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J0916_16015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J0916_16020	COG0569	domain protein
J0916_16025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J0916_16030	COG0123	including yeast histone deacetylase and acetoin utilization protein
J0916_16040	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J0916_16050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J0916_16055	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J0916_16080	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
J0916_16090	COG0406	alpha-ribazole phosphatase activity
J0916_16100	COG0785	Cytochrome C biogenesis protein
J0916_16110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J0916_16125	COG0488	(ABC) transporter
J0916_16135	COG2515	1-aminocyclopropane-1-carboxylate deaminase
J0916_16145	COG1132	(ABC) transporter
J0916_16150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J0916_16155	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
J0916_16175	COG0673	inositol 2-dehydrogenase activity
J0916_16190	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J0916_16205	COG1957	nucleoside hydrolase
J0916_16210	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_16215	COG1960	acyl-CoA dehydrogenase activity
J0916_16245	COG3971	2-oxopent-4-enoate hydratase activity
J0916_16255	COG1012	belongs to the aldehyde dehydrogenase family
J0916_16260	COG1802	Transcriptional regulator
J0916_16275	COG0477	Major facilitator Superfamily
J0916_16280	COG0583	DNA-binding transcription factor activity
J0916_16290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J0916_16300	COG0604	alcohol dehydrogenase
J0916_16315	COG0343	queuine tRNA-ribosyltransferase activity
J0916_16345	COG0626	cystathionine gamma-synthase activity
J0916_16385	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
J0916_16395	COG0564	pseudouridine synthase activity
J0916_16400	COG2223	nitrite transmembrane transporter activity
J0916_16410	COG1201	RNA secondary structure unwinding
J0916_16430	COG2205	protein histidine kinase activity
J0916_16435	COG0745	RESPONSE REGULATOR receiver
J0916_16455	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
J0916_16480	COG2062	phosphohistidine phosphatase, SixA
J0916_16485	COG1511	domain protein
J0916_16490	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
J0916_16495	COG1940	carbohydrate kinase activity
J0916_16500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J0916_16505	COG4608	Belongs to the ABC transporter superfamily
J0916_16510	COG0444	Belongs to the ABC transporter superfamily
J0916_16520	COG2186	Transcriptional regulator
J0916_16535	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
J0916_16545	COG1959	2 iron, 2 sulfur cluster binding
J0916_16560	COG0514	ATP-dependent DNA helicase (RecQ)
J0916_16575	COG4948	Mandelate Racemase Muconate Lactonizing
J0916_16605	COG1172	Belongs to the binding-protein-dependent transport system permease family
J0916_16620	COG2186	Transcriptional regulator
J0916_16630	COG1505	serine-type exopeptidase activity
J0916_16640	COG1960	acyl-CoA dehydrogenase activity
J0916_16645	COG0045	succinate-CoA ligase (ADP-forming) activity
J0916_16650	COG1309	transcriptional regulator
J0916_16665	COG1012	belongs to the aldehyde dehydrogenase family
J0916_16670	COG0477	Major facilitator Superfamily
J0916_16675	COG2030	dehydratase
J0916_16685	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
J0916_16700	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_16700	COG3321	synthase
J0916_16700	COG0604	alcohol dehydrogenase
J0916_16710	COG0110	maltose O-acetyltransferase activity
J0916_16715	COG1966	Carbon starvation protein
J0916_16745	COG3842	ATPase activity
J0916_16775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J0916_16780	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J0916_16795	COG0384	phenazine biosynthesis protein PhzF
J0916_16805	COG0588	phosphoglycerate mutase activity
J0916_16810	COG0704	Plays a role in the regulation of phosphate uptake
J0916_16815	COG5002	protein histidine kinase activity
J0916_16820	COG0745	RESPONSE REGULATOR receiver
J0916_16830	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J0916_16840	COG0215	cysteine-tRNA ligase activity
J0916_16845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J0916_16860	COG0366	Alpha amylase catalytic
J0916_16865	COG0366	Alpha amylase catalytic
J0916_16870	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J0916_16910	COG0366	Alpha amylase catalytic
J0916_16915	COG0277	FAD linked oxidase domain protein
J0916_16925	COG3842	ATPase activity
J0916_17025	COG2801	Transposase and inactivated derivatives
J0916_17050	COG2226	methyltransferase