locus-tag	class	description
F8G81_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F8G81_00010	COG0592	DNA-directed DNA polymerase activity
F8G81_00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F8G81_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F8G81_00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
F8G81_00030	COG0187	DNA topoisomerase II activity
F8G81_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F8G81_00040	COG3266	domain, Protein
F8G81_00060	COG1215	transferase activity, transferring glycosyl groups
F8G81_00075	COG0705	Rhomboid family
F8G81_00080	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F8G81_00085	COG2818	Glycosylase
F8G81_00095	COG3764	Sortase (surface protein transpeptidase)
F8G81_00105	COG0515	serine threonine protein kinase
F8G81_00110	COG0515	serine threonine protein kinase
F8G81_00115	COG0768	penicillin binding
F8G81_00130	COG1716	ATPase activity
F8G81_00135	COG1716	ATPase activity
F8G81_00145	COG0589	response to stress
F8G81_00150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8G81_00155	COG0747	negative chemotaxis
F8G81_00165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8G81_00170	COG0444	Belongs to the ABC transporter superfamily
F8G81_00175	COG4608	Belongs to the ABC transporter superfamily
F8G81_00185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8G81_00190	COG4948	Mandelate Racemase Muconate Lactonizing
F8G81_00195	COG0583	DNA-binding transcription factor activity
F8G81_00200	COG1609	Transcriptional regulator
F8G81_00215	COG4948	Mandelate Racemase Muconate Lactonizing
F8G81_00225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8G81_00230	COG0583	DNA-binding transcription factor activity
F8G81_00250	COG0589	response to stress
F8G81_00285	COG1064	alcohol dehydrogenase
F8G81_00305	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F8G81_00310	COG1984	allophanate hydrolase subunit 2
F8G81_00315	COG4770	biotin carboxylase activity
F8G81_00325	COG4336	lyase activity
F8G81_00330	COG1914	H( )-stimulated, divalent metal cation uptake system
F8G81_00350	COG2376	Dihydroxyacetone kinase
F8G81_00360	COG1175	transmembrane transport
F8G81_00365	COG0395	ABC-type sugar transport system, permease component
F8G81_00370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F8G81_00380	COG1414	Transcriptional regulator
F8G81_00385	COG3485	protocatechuate 3,4-dioxygenase
F8G81_00390	COG0667	Aldo Keto reductase
F8G81_00400	COG4214	carbohydrate transport
F8G81_00410	COG4213	ABC transporter substrate-binding protein
F8G81_00415	COG1414	Transcriptional regulator
F8G81_00430	COG0673	inositol 2-dehydrogenase activity
F8G81_00440	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F8G81_00450	COG0183	Belongs to the thiolase family
F8G81_00470	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_00490	COG1129	ABC transporter
F8G81_00500	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_00510	COG1454	alcohol dehydrogenase
F8G81_00515	COG1063	alcohol dehydrogenase
F8G81_00540	COG0833	amino acid
F8G81_00575	COG0277	FAD linked oxidase domain protein
F8G81_00585	COG1357	PFAM Pentapeptide repeats (8 copies)
F8G81_00595	COG2409	Drug exporters of the RND superfamily
F8G81_00625	COG1175	transmembrane transport
F8G81_00640	COG3534	alpha-L-arabinofuranosidase
F8G81_00650	COG1609	Transcriptional regulator
F8G81_00655	COG1162	GTPase activity
F8G81_00680	COG3321	synthase
F8G81_00680	COG0604	alcohol dehydrogenase
F8G81_00680	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_00700	COG3706	GGDEF domain
F8G81_00705	COG2814	Major facilitator Superfamily
F8G81_00710	COG0583	DNA-binding transcription factor activity
F8G81_00725	COG0395	ABC-type sugar transport system, permease component
F8G81_00730	COG4209	transmembrane transport
F8G81_00740	COG1609	Transcriptional regulator
F8G81_00745	COG0395	ABC-type sugar transport system, permease component
F8G81_00750	COG1175	transmembrane transport
F8G81_00755	COG1653	transport
F8G81_00775	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_00800	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_00810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8G81_00820	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_00840	COG0477	Major facilitator Superfamily
F8G81_00850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8G81_00880	COG2207	Transcriptional regulator
F8G81_00885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F8G81_00900	COG1733	regulation of RNA biosynthetic process
F8G81_00935	COG1733	regulation of RNA biosynthetic process
F8G81_00940	COG0702	epimerase
F8G81_00965	COG2197	response regulator
F8G81_00975	COG1595	DNA-templated transcription, initiation
F8G81_00995	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F8G81_01000	COG0673	inositol 2-dehydrogenase activity
F8G81_01010	COG0673	inositol 2-dehydrogenase activity
F8G81_01020	COG0659	secondary active sulfate transmembrane transporter activity
F8G81_01030	COG1609	Transcriptional regulator
F8G81_01045	COG0726	polysaccharide deacetylase
F8G81_01065	COG0346	lactoylglutathione lyase activity
F8G81_01080	COG0477	Major facilitator Superfamily
F8G81_01100	COG1595	DNA-templated transcription, initiation
F8G81_01130	COG0800	Aldolase
F8G81_01135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8G81_01140	COG4948	Mandelate Racemase Muconate Lactonizing
F8G81_01145	COG0395	ABC-type sugar transport system, permease component
F8G81_01150	COG1175	transmembrane transport
F8G81_01160	COG1940	carbohydrate kinase activity
F8G81_01190	COG0561	phosphatase activity
F8G81_01200	COG0584	glycerophosphoryl diester phosphodiesterase
F8G81_01220	COG2200	EAL domain
F8G81_01235	COG4106	trans-aconitate 2-methyltransferase activity
F8G81_01245	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_01250	COG1929	Belongs to the glycerate kinase type-1 family
F8G81_01265	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_01290	COG2233	PERMEase
F8G81_01295	COG0778	Nitroreductase
F8G81_01350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F8G81_01355	COG0492	ferredoxin-NADP+ reductase activity
F8G81_01365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F8G81_01375	COG2066	Belongs to the glutaminase family
F8G81_01395	COG5416	Lipopolysaccharide assembly protein A domain
F8G81_01415	COG0577	efflux transmembrane transporter activity
F8G81_01415	COG1136	(ABC) transporter
F8G81_01420	COG0577	efflux transmembrane transporter activity
F8G81_01420	COG1136	(ABC) transporter
F8G81_01430	COG3940	Belongs to the glycosyl hydrolase 43 family
F8G81_01435	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_01445	COG0833	amino acid
F8G81_01460	COG1414	Transcriptional regulator
F8G81_01475	COG0154	amidase activity
F8G81_01480	COG3340	Belongs to the peptidase S51 family
F8G81_01485	COG0425	Belongs to the sulfur carrier protein TusA family
F8G81_01485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F8G81_01500	COG1597	lipid kinase activity
F8G81_01505	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F8G81_01510	COG0561	phosphatase activity
F8G81_01520	COG0395	ABC-type sugar transport system, permease component
F8G81_01525	COG1175	transmembrane transport
F8G81_01535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8G81_01585	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F8G81_01605	COG2197	response regulator
F8G81_01640	COG0037	tRNA processing
F8G81_01650	COG1621	beta-fructofuranosidase activity
F8G81_01675	COG0395	ABC-type sugar transport system, permease component
F8G81_01685	COG1609	Transcriptional regulator
F8G81_01690	COG1621	beta-fructofuranosidase activity
F8G81_01695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F8G81_01700	COG0302	gtp cyclohydrolase
F8G81_01705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F8G81_01710	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F8G81_01740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F8G81_01745	COG3387	PFAM Glycoside hydrolase 15-related
F8G81_01760	COG0693	protein deglycase activity
F8G81_01765	COG2814	Major facilitator Superfamily
F8G81_01785	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F8G81_01805	COG1506	peptidase
F8G81_01805	COG0823	Involved in the tonB-independent uptake of proteins
F8G81_01810	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F8G81_01820	COG2376	Dihydroxyacetone kinase
F8G81_01825	COG1461	Dihydroxyacetone kinase
F8G81_01870	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
F8G81_01875	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F8G81_01880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F8G81_01905	COG1126	abc transporter atp-binding protein
F8G81_01910	COG0765	amino acid transport
F8G81_01915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8G81_01920	COG1802	Transcriptional regulator
F8G81_01930	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F8G81_01940	COG1126	abc transporter atp-binding protein
F8G81_01945	COG0765	amino acid transport
F8G81_01960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8G81_01965	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_01970	COG0473	3-isopropylmalate dehydrogenase activity
F8G81_01995	COG1063	alcohol dehydrogenase
F8G81_02000	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F8G81_02010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F8G81_02055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F8G81_02070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F8G81_02075	COG0306	phosphate transporter
F8G81_02100	COG1609	Transcriptional regulator
F8G81_02105	COG1172	Belongs to the binding-protein-dependent transport system permease family
F8G81_02110	COG1172	Belongs to the binding-protein-dependent transport system permease family
F8G81_02120	COG1879	ABC-type sugar transport system periplasmic component
F8G81_02135	COG2160	L-arabinose isomerase activity
F8G81_02160	COG1609	Transcriptional regulator
F8G81_02180	COG0831	urea catabolic process
F8G81_02185	COG0832	Belongs to the urease beta subunit family
F8G81_02190	COG0804	urea catabolic process
F8G81_02195	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
F8G81_02200	COG0830	nickel cation binding
F8G81_02205	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F8G81_02210	COG0829	nickel cation binding
F8G81_02215	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
F8G81_02250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8G81_02280	COG1621	beta-fructofuranosidase activity
F8G81_02290	COG0277	FAD linked oxidase domain protein
F8G81_02290	COG0247	lactate metabolic process
F8G81_02295	COG0583	DNA-binding transcription factor activity
F8G81_02315	COG2890	protein-(glutamine-N5) methyltransferase activity
F8G81_02335	COG2261	transglycosylase associated protein
F8G81_02345	COG3401	FG-GAP repeat protein
F8G81_02355	COG0667	Aldo Keto reductase
F8G81_02360	COG0656	L-ascorbic acid biosynthetic process
F8G81_02375	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
F8G81_02375	COG4124	Belongs to the glycosyl hydrolase 26 family
F8G81_02390	COG3360	Dodecin
F8G81_02395	COG0395	ABC-type sugar transport system, permease component
F8G81_02400	COG1175	transmembrane transport
F8G81_02405	COG1653	transport
F8G81_02420	COG1609	Transcriptional regulator
F8G81_02435	COG2084	Dehydrogenase
F8G81_02440	COG2610	gluconate transmembrane transporter activity
F8G81_02480	COG0076	glutamate decarboxylase activity
F8G81_02485	COG3486	L-lysine 6-monooxygenase (NADPH) activity
F8G81_02500	COG0300	oxidoreductase activity
F8G81_02510	COG0477	Major facilitator Superfamily
F8G81_02530	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F8G81_02540	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F8G81_02565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8G81_02565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8G81_02565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8G81_02575	COG1349	DNA-binding transcription factor activity
F8G81_02595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F8G81_02610	COG1131	(ABC) transporter
F8G81_02625	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F8G81_02635	COG2733	membrane
F8G81_02640	COG0584	glycerophosphoryl diester phosphodiesterase
F8G81_02700	COG4122	O-methyltransferase activity
F8G81_02705	COG3237	CsbD-like
F8G81_02715	COG1295	ribonuclease BN
F8G81_02750	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F8G81_02755	COG0859	PFAM glycosyl transferase family 9
F8G81_02765	COG0297	glycogen (starch) synthase activity
F8G81_02770	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F8G81_02775	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F8G81_02775	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F8G81_02780	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_02790	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_02795	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F8G81_02795	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F8G81_02815	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_02825	COG0745	RESPONSE REGULATOR receiver
F8G81_02835	COG1476	TRANSCRIPTIONal
F8G81_02840	COG3321	synthase
F8G81_02840	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_02840	COG0604	alcohol dehydrogenase
F8G81_02845	COG2186	Transcriptional regulator
F8G81_02865	COG0596	Alpha beta hydrolase
F8G81_02875	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F8G81_02900	COG1175	transmembrane transport
F8G81_02910	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_02915	COG0589	response to stress
F8G81_02935	COG3290	protein histidine kinase activity
F8G81_02940	COG4565	transcriptional regulatory protein
F8G81_02950	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
F8G81_02965	COG2252	PERMEase
F8G81_02985	COG3848	Pyruvate phosphate dikinase
F8G81_02985	COG0574	Belongs to the PEP-utilizing enzyme family
F8G81_03010	COG3883	PFAM NLP P60 protein
F8G81_03010	COG0791	NLP P60 protein
F8G81_03020	COG3220	belongs to the UPF0276 family
F8G81_03045	COG1796	DNA polymerase
F8G81_03045	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F8G81_03080	COG1609	Transcriptional regulator
F8G81_03090	COG0601	transmembrane transport
F8G81_03095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8G81_03100	COG0444	Belongs to the ABC transporter superfamily
F8G81_03105	COG4608	Belongs to the ABC transporter superfamily
F8G81_03125	COG2409	Drug exporters of the RND superfamily
F8G81_03175	COG0366	Alpha amylase catalytic
F8G81_03200	COG1609	Transcriptional regulator
F8G81_03220	COG1024	Enoyl-CoA hydratase
F8G81_03235	COG0492	ferredoxin-NADP+ reductase activity
F8G81_03245	COG0586	Pfam SNARE associated Golgi protein
F8G81_03255	COG1960	acyl-CoA dehydrogenase activity
F8G81_03280	COG1278	Cold shock
F8G81_03290	COG4948	Mandelate Racemase Muconate Lactonizing
F8G81_03300	COG1175	transmembrane transport
F8G81_03320	COG2197	response regulator
F8G81_03325	COG4585	Histidine kinase
F8G81_03340	COG0183	Belongs to the thiolase family
F8G81_03350	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F8G81_03365	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F8G81_03395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F8G81_03395	COG0357	Ribosomal RNA small subunit methyltransferase G
F8G81_03400	COG0191	fructose-bisphosphate aldolase activity
F8G81_03415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F8G81_03420	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F8G81_03450	COG0395	ABC-type sugar transport system, permease component
F8G81_03455	COG3622	Belongs to the hyi family
F8G81_03460	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
F8G81_03485	COG0673	inositol 2-dehydrogenase activity
F8G81_03505	COG1940	carbohydrate kinase activity
F8G81_03510	COG0673	inositol 2-dehydrogenase activity
F8G81_03520	COG0477	Major facilitator Superfamily
F8G81_03530	COG1595	DNA-templated transcription, initiation
F8G81_03540	COG1832	CoA-binding protein
F8G81_03550	COG2315	Protein conserved in bacteria
F8G81_03555	COG4762	Protein conserved in bacteria
F8G81_03575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F8G81_03580	COG0047	phosphoribosylformylglycinamidine synthase activity
F8G81_03585	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F8G81_03615	COG1846	Transcriptional regulator
F8G81_03650	COG0519	Catalyzes the synthesis of GMP from XMP
F8G81_03655	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F8G81_03670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F8G81_03670	COG3323	Protein of unknown function (DUF1653)
F8G81_03695	COG0739	heme binding
F8G81_03695	COG1196	nuclear chromosome segregation
F8G81_03695	COG0741	lytic transglycosylase activity
F8G81_03700	COG0386	Belongs to the glutathione peroxidase family
F8G81_03705	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F8G81_03710	COG0438	transferase activity, transferring glycosyl groups
F8G81_03730	COG1309	transcriptional regulator
F8G81_03740	COG0438	transferase activity, transferring glycosyl groups
F8G81_03760	COG0673	inositol 2-dehydrogenase activity
F8G81_03770	COG1940	carbohydrate kinase activity
F8G81_03775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8G81_03780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F8G81_03790	COG1396	sequence-specific DNA binding
F8G81_03805	COG2205	protein histidine kinase activity
F8G81_03810	COG0745	RESPONSE REGULATOR receiver
F8G81_03815	COG0477	Major facilitator Superfamily
F8G81_03830	COG1309	transcriptional regulator
F8G81_03840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8G81_03845	COG1940	carbohydrate kinase activity
F8G81_03855	COG1175	transmembrane transport
F8G81_03860	COG0395	ABC-type sugar transport system, permease component
F8G81_03865	COG1940	carbohydrate kinase activity
F8G81_03870	COG0366	Alpha amylase catalytic
F8G81_03880	COG0343	queuine tRNA-ribosyltransferase activity
F8G81_03910	COG3842	ATPase activity
F8G81_03935	COG1960	acyl-CoA dehydrogenase activity
F8G81_03955	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F8G81_03975	COG0564	pseudouridine synthase activity
F8G81_03995	COG2364	Membrane
F8G81_04000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F8G81_04005	COG1201	RNA secondary structure unwinding
F8G81_04010	COG0723	plastoquinol--plastocyanin reductase activity
F8G81_04035	COG2070	2-Nitropropane dioxygenase
F8G81_04070	COG0438	transferase activity, transferring glycosyl groups
F8G81_04080	COG0671	phosphoesterase, PA-phosphatase related
F8G81_04085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F8G81_04105	COG2205	protein histidine kinase activity
F8G81_04110	COG0745	RESPONSE REGULATOR receiver
F8G81_04120	COG2062	phosphohistidine phosphatase, SixA
F8G81_04125	COG0583	DNA-binding transcription factor activity
F8G81_04130	COG0697	spore germination
F8G81_04135	COG1309	transcriptional regulator
F8G81_04140	COG1511	domain protein
F8G81_04160	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
F8G81_04165	COG1017	nitric oxide dioxygenase activity
F8G81_04165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F8G81_04180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F8G81_04185	COG0514	ATP-dependent DNA helicase (RecQ)
F8G81_04200	COG1505	serine-type exopeptidase activity
F8G81_04220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8G81_04235	COG0604	alcohol dehydrogenase
F8G81_04235	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_04235	COG3321	synthase
F8G81_04245	COG1136	(ABC) transporter
F8G81_04245	COG0577	efflux transmembrane transporter activity
F8G81_04275	COG0656	L-ascorbic acid biosynthetic process
F8G81_04300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F8G81_04305	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F8G81_04325	COG0588	phosphoglycerate mutase activity
F8G81_04335	COG5002	protein histidine kinase activity
F8G81_04355	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F8G81_04360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F8G81_04365	COG0215	cysteine-tRNA ligase activity
F8G81_04370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F8G81_04395	COG0366	Alpha amylase catalytic
F8G81_04405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F8G81_04430	COG1609	Transcriptional regulator
F8G81_04435	COG0366	Alpha amylase catalytic
F8G81_04440	COG0277	FAD linked oxidase domain protein
F8G81_04450	COG3842	ATPase activity
F8G81_04460	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
F8G81_04500	COG2957	Belongs to the agmatine deiminase family
F8G81_04510	COG0783	Belongs to the Dps family
F8G81_04525	COG0477	Major facilitator Superfamily
F8G81_04535	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F8G81_04535	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F8G81_04540	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8G81_04545	COG0509	glycine decarboxylation via glycine cleavage system
F8G81_04595	COG1278	Cold shock
F8G81_04605	COG0459	protein refolding
F8G81_04620	COG0328	RNA-DNA hybrid ribonuclease activity
F8G81_04630	COG2205	protein histidine kinase activity
F8G81_04635	COG0745	RESPONSE REGULATOR receiver
F8G81_04655	COG1278	Cold shock
F8G81_04675	COG0739	heme binding
F8G81_04680	COG3103	Sh3 type 3 domain protein
F8G81_04680	COG1388	LysM domain
F8G81_04680	COG0791	NLP P60 protein
F8G81_04700	COG0303	'Molybdopterin
F8G81_04705	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F8G81_04725	COG0488	(ABC) transporter
F8G81_04730	COG1132	(ABC) transporter
F8G81_04735	COG0494	nUDIX hydrolase
F8G81_04765	COG0483	inositol monophosphate 1-phosphatase activity
F8G81_04775	COG1819	glycosyl
F8G81_04785	COG0045	succinate-CoA ligase (ADP-forming) activity
F8G81_04800	COG0640	Transcriptional regulator
F8G81_04810	COG2814	Major facilitator Superfamily
F8G81_04815	COG1942	4-Oxalocrotonate Tautomerase
F8G81_04820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8G81_04830	COG3962	Belongs to the TPP enzyme family
F8G81_04845	COG0673	inositol 2-dehydrogenase activity
F8G81_04850	COG1082	Xylose isomerase domain protein TIM barrel
F8G81_04880	COG1172	Belongs to the binding-protein-dependent transport system permease family
F8G81_04890	COG0673	inositol 2-dehydrogenase activity
F8G81_04895	COG0673	inositol 2-dehydrogenase activity
F8G81_04910	COG0673	inositol 2-dehydrogenase activity
F8G81_04915	COG3718	enzyme involved in inositol metabolism
F8G81_04920	COG2188	Transcriptional regulator
F8G81_04950	COG1396	sequence-specific DNA binding
F8G81_04965	COG0028	Belongs to the TPP enzyme family
F8G81_05000	COG1401	restriction endodeoxyribonuclease activity
F8G81_05010	COG5002	protein histidine kinase activity
F8G81_05015	COG0745	RESPONSE REGULATOR receiver
F8G81_05050	COG1902	pentaerythritol trinitrate reductase activity
F8G81_05095	COG0833	amino acid
F8G81_05100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8G81_05115	COG3583	domain protein
F8G81_05125	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F8G81_05130	COG3103	Sh3 type 3 domain protein
F8G81_05130	COG0366	Alpha amylase catalytic
F8G81_05135	COG2353	YceI-like domain
F8G81_05140	COG1254	Belongs to the acylphosphatase family
F8G81_05185	COG0477	Major facilitator Superfamily
F8G81_05200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8G81_05205	COG1914	H( )-stimulated, divalent metal cation uptake system
F8G81_05220	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_05225	COG0395	ABC-type sugar transport system, permease component
F8G81_05230	COG1175	transmembrane transport
F8G81_05240	COG3684	Belongs to the aldolase LacD family
F8G81_05250	COG0673	inositol 2-dehydrogenase activity
F8G81_05270	COG4209	transmembrane transport
F8G81_05275	COG0395	ABC-type sugar transport system, permease component
F8G81_05320	COG2267	carboxylic ester hydrolase activity
F8G81_05335	COG0531	amino acid
F8G81_05355	COG1609	Transcriptional regulator
F8G81_05360	COG1472	Belongs to the glycosyl hydrolase 3 family
F8G81_05365	COG0673	inositol 2-dehydrogenase activity
F8G81_05380	COG1609	Transcriptional regulator
F8G81_05440	COG2318	DinB family
F8G81_05455	COG2135	peptidase activity
F8G81_05470	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F8G81_05490	COG2814	Major facilitator Superfamily
F8G81_05495	COG0667	Aldo Keto reductase
F8G81_05510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F8G81_05525	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F8G81_05540	COG2814	Major facilitator Superfamily
F8G81_05590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F8G81_05600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F8G81_05630	COG2814	Major facilitator Superfamily
F8G81_05635	COG1846	Transcriptional regulator
F8G81_05640	COG3548	integral membrane protein
F8G81_05745	COG1309	transcriptional regulator
F8G81_05755	COG1253	flavin adenine dinucleotide binding
F8G81_05780	COG2354	Protein conserved in bacteria
F8G81_05795	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F8G81_05895	COG0028	Belongs to the TPP enzyme family
F8G81_05905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8G81_05910	COG1113	amino acid transport
F8G81_05945	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F8G81_05955	COG1201	RNA secondary structure unwinding
F8G81_05960	COG0210	DNA helicase
F8G81_05980	COG1074	ATP-dependent DNA helicase activity
F8G81_06030	COG2267	carboxylic ester hydrolase activity
F8G81_06040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F8G81_06050	COG0183	Belongs to the thiolase family
F8G81_06055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F8G81_06065	COG1024	Enoyl-CoA hydratase
F8G81_06100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8G81_06105	COG4585	Histidine kinase
F8G81_06150	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
F8G81_06160	COG1309	transcriptional regulator
F8G81_06165	COG3540	Alkaline phosphatase
F8G81_06185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F8G81_06225	COG1278	Cold shock
F8G81_06235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F8G81_06245	COG3265	gluconokinase activity
F8G81_06250	COG2610	gluconate transmembrane transporter activity
F8G81_06290	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F8G81_06310	COG5001	Diguanylate cyclase
F8G81_06310	COG3300	MHYT domain
F8G81_06315	COG2261	transglycosylase associated protein
F8G81_06320	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F8G81_06335	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
F8G81_06370	COG0477	Major facilitator Superfamily
F8G81_06375	COG0138	bifunctional purine biosynthesis protein purh
F8G81_06390	COG1116	anion transmembrane transporter activity
F8G81_06395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8G81_06415	COG2838	Isocitrate dehydrogenase
F8G81_06425	COG0515	serine threonine protein kinase
F8G81_06440	COG0673	inositol 2-dehydrogenase activity
F8G81_06455	COG0531	amino acid
F8G81_06485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F8G81_06490	COG1131	(ABC) transporter
F8G81_06515	COG0180	Tryptophanyl-tRNA synthetase
F8G81_06540	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F8G81_06555	COG2009	succinate dehydrogenase
F8G81_06565	COG1473	amidohydrolase
F8G81_06565	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F8G81_06570	COG1846	Transcriptional regulator
F8G81_06575	COG1764	response to oxidative stress
F8G81_06580	COG2130	NADP-dependent
F8G81_06585	COG1744	ABC transporter substrate-binding protein PnrA-like
F8G81_06590	COG3845	ABC transporter
F8G81_06595	COG4603	Belongs to the binding-protein-dependent transport system permease family
F8G81_06600	COG1079	Belongs to the binding-protein-dependent transport system permease family
F8G81_06620	COG0586	Pfam SNARE associated Golgi protein
F8G81_06625	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F8G81_06630	COG3956	TIGRFAM MazG family protein
F8G81_06635	COG0148	phosphopyruvate hydratase activity
F8G81_06660	COG1252	NADH dehydrogenase
F8G81_06705	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F8G81_06715	COG1349	DNA-binding transcription factor activity
F8G81_06720	COG2017	converts alpha-aldose to the beta-anomer
F8G81_06730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F8G81_06740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F8G81_06750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F8G81_06760	COG1331	Highly conserved protein containing a thioredoxin domain
F8G81_06770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F8G81_06775	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F8G81_06805	COG0114	fumarate hydratase activity
F8G81_06810	COG0288	reversible hydration of carbon dioxide
F8G81_06820	COG1494	fructose-1,6-bisphosphatase
F8G81_06835	COG1482	cell wall glycoprotein biosynthetic process
F8G81_06845	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F8G81_06895	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F8G81_06900	COG1376	ErfK ybiS ycfS ynhG family protein
F8G81_06950	COG0714	Associated with various cellular activities
F8G81_06955	COG0084	hydrolase, TatD family'
F8G81_06960	COG3583	domain protein
F8G81_06965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F8G81_06970	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F8G81_06975	COG0488	(ABC) transporter
F8G81_06995	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F8G81_07005	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F8G81_07010	COG0193	aminoacyl-tRNA hydrolase activity
F8G81_07030	COG0822	iron-sulfur transferase activity
F8G81_07035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F8G81_07050	COG0702	epimerase
F8G81_07060	COG1988	membrane-bound metal-dependent
F8G81_07080	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F8G81_07085	COG0446	pyridine nucleotide-disulphide oxidoreductase
F8G81_07100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F8G81_07110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F8G81_07115	COG1959	2 iron, 2 sulfur cluster binding
F8G81_07140	COG0243	molybdopterin cofactor binding
F8G81_07145	COG2223	nitrite transmembrane transporter activity
F8G81_07150	COG0477	Major facilitator Superfamily
F8G81_07165	COG4770	biotin carboxylase activity
F8G81_07170	COG0424	maF-like protein
F8G81_07180	COG1823	symporter activity
F8G81_07195	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F8G81_07200	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_07205	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F8G81_07205	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F8G81_07230	COG0714	Associated with various cellular activities
F8G81_07250	COG0631	protein serine/threonine phosphatase activity
F8G81_07270	COG1674	ftsk spoiiie
F8G81_07285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F8G81_07290	COG0483	inositol monophosphate 1-phosphatase activity
F8G81_07300	COG0251	oxidation-reduction process
F8G81_07305	COG4565	transcriptional regulatory protein
F8G81_07310	COG3290	protein histidine kinase activity
F8G81_07315	COG2851	Citrate transporter
F8G81_07320	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F8G81_07325	COG0154	amidase activity
F8G81_07330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F8G81_07340	COG0583	DNA-binding transcription factor activity
F8G81_07345	COG1063	alcohol dehydrogenase
F8G81_07350	COG0156	8-amino-7-oxononanoate synthase activity
F8G81_07360	COG1228	amidohydrolase
F8G81_07385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F8G81_07405	COG0400	carboxylic ester hydrolase activity
F8G81_07420	COG0423	glycine-tRNA ligase activity
F8G81_07450	COG0358	DNA primase activity
F8G81_07475	COG2814	Major facilitator Superfamily
F8G81_07495	COG0438	transferase activity, transferring glycosyl groups
F8G81_07535	COG2189	Belongs to the N(4) N(6)-methyltransferase family
F8G81_07620	COG0052	Belongs to the universal ribosomal protein uS2 family
F8G81_07625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F8G81_07630	COG0528	UMP kinase activity
F8G81_07635	COG0233	cytoplasmic translational termination
F8G81_07650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F8G81_07665	COG3275	phosphorelay sensor kinase activity
F8G81_07675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F8G81_07695	COG0456	acetyltransferase
F8G81_07705	COG1522	sequence-specific DNA binding
F8G81_07715	COG0022	dehydrogenase e1 component
F8G81_07720	COG0508	dehydrogenase complex catalyzes the overall conversion of
F8G81_07730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F8G81_07740	COG1960	acyl-CoA dehydrogenase activity
F8G81_07775	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F8G81_07780	COG0750	zinc metalloprotease
F8G81_07800	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F8G81_07815	COG1309	transcriptional regulator
F8G81_07830	COG0442	prolyl-tRNA aminoacylation
F8G81_07860	COG0779	Required for maturation of 30S ribosomal subunits
F8G81_07875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F8G81_07880	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F8G81_07885	COG0590	tRNA wobble adenosine to inosine editing
F8G81_07890	COG3118	belongs to the thioredoxin family
F8G81_07895	COG0436	Aminotransferase
F8G81_07900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F8G81_07915	COG0196	riboflavin kinase activity
F8G81_07920	COG3483	tryptophan 2,3-dioxygenase activity
F8G81_07925	COG3844	kynureninase activity
F8G81_07930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F8G81_07935	COG1185	polyribonucleotide nucleotidyltransferase activity
F8G81_07940	COG0612	Peptidase, M16
F8G81_07980	COG0745	RESPONSE REGULATOR receiver
F8G81_07985	COG5002	protein histidine kinase activity
F8G81_08005	COG0521	Mo-molybdopterin cofactor biosynthetic process
F8G81_08015	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F8G81_08045	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F8G81_08050	COG1674	ftsk spoiiie
F8G81_08060	COG1546	Belongs to the CinA family
F8G81_08060	COG1058	Belongs to the CinA family
F8G81_08065	COG1396	sequence-specific DNA binding
F8G81_08080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F8G81_08085	COG2137	regulation of response to DNA damage stimulus
F8G81_08090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F8G81_08095	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F8G81_08100	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F8G81_08105	COG2813	Specifically methylates the guanine in position
F8G81_08110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F8G81_08120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F8G81_08130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8G81_08135	COG0131	Imidazoleglycerol-phosphate dehydratase
F8G81_08140	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F8G81_08145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F8G81_08165	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F8G81_08170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F8G81_08175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F8G81_08180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F8G81_08220	COG2814	Major facilitator Superfamily
F8G81_08225	COG2816	NAD+ diphosphatase activity
F8G81_08245	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F8G81_08250	COG0072	phenylalanine-tRNA ligase activity
F8G81_08250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F8G81_08265	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F8G81_08270	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F8G81_08275	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F8G81_08280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F8G81_08285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F8G81_08290	COG1438	arginine binding
F8G81_08295	COG0137	argininosuccinate synthase activity
F8G81_08300	COG0165	Argininosuccinate lyase
F8G81_08305	COG0259	pyridoxamine-phosphate oxidase activity
F8G81_08315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F8G81_08315	COG2169	Transcriptional regulator
F8G81_08325	COG2094	Belongs to the DNA glycosylase MPG family
F8G81_08335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F8G81_08360	COG0647	UMP catabolic process
F8G81_08375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F8G81_08380	COG0497	DNA recombination
F8G81_08390	COG0504	CTP synthase activity
F8G81_08395	COG0494	nUDIX hydrolase
F8G81_08435	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
F8G81_08440	COG2079	MmgE PrpD family protein
F8G81_08455	COG3290	protein histidine kinase activity
F8G81_08460	COG1301	dicarboxylic acid transport
F8G81_08470	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F8G81_08475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F8G81_08490	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F8G81_08500	COG1160	GTP binding
F8G81_08515	COG0789	Transcriptional regulator
F8G81_08520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F8G81_08530	COG0509	glycine decarboxylation via glycine cleavage system
F8G81_08555	COG1192	Involved in chromosome partitioning
F8G81_08560	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F8G81_08570	COG1940	carbohydrate kinase activity
F8G81_08595	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F8G81_08600	COG0515	serine threonine protein kinase
F8G81_08600	COG2815	serine threonine protein kinase
F8G81_08615	COG0142	geranyltranstransferase activity
F8G81_08625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F8G81_08635	COG2001	Belongs to the MraZ family
F8G81_08640	COG0275	rRNA processing
F8G81_08650	COG0768	penicillin binding
F8G81_08655	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F8G81_08665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F8G81_08670	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F8G81_08680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F8G81_08685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F8G81_08690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F8G81_08695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F8G81_08705	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F8G81_08710	COG1799	cell septum assembly
F8G81_08720	COG3599	regulation of cell shape
F8G81_08725	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F8G81_08735	COG0587	DNA-directed DNA polymerase activity
F8G81_08750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F8G81_08755	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F8G81_08760	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_08780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F8G81_08785	COG0174	glutamine synthetase
F8G81_08790	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F8G81_08810	COG2801	Transposase and inactivated derivatives
F8G81_08840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F8G81_08845	COG0321	lipoyl(octanoyl) transferase activity
F8G81_08855	COG1090	epimerase
F8G81_08860	COG0793	Belongs to the peptidase S41A family
F8G81_08860	COG4946	Tricorn protease homolog
F8G81_08875	COG0508	dehydrogenase complex catalyzes the overall conversion of
F8G81_08880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F8G81_08885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F8G81_08905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F8G81_08930	COG1271	oxidase subunit
F8G81_08935	COG1294	oxidase, subunit
F8G81_08940	COG4988	ABC transporter
F8G81_08955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F8G81_08975	COG1435	thymidine kinase activity
F8G81_09020	COG0569	domain protein
F8G81_09025	COG0531	amino acid
F8G81_09030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F8G81_09035	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F8G81_09040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F8G81_09045	COG3557	Belongs to the UPF0374 family
F8G81_09055	COG0667	Aldo Keto reductase
F8G81_09075	COG1122	ATPase activity
F8G81_09080	COG1024	Enoyl-CoA hydratase
F8G81_09080	COG1250	3-hydroxyacyl-CoA dehydrogenase
F8G81_09085	COG0183	Belongs to the thiolase family
F8G81_09090	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F8G81_09115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F8G81_09130	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F8G81_09150	COG3135	benzoate transporter
F8G81_09195	COG0242	peptide deformylase activity
F8G81_09200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F8G81_09210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F8G81_09225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F8G81_09225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F8G81_09235	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F8G81_09240	COG0140	phosphoribosyl-ATP diphosphatase activity
F8G81_09245	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F8G81_09250	COG0107	imidazoleglycerol-phosphate synthase activity
F8G81_09260	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F8G81_09280	COG0134	indole-3-glycerol-phosphate synthase activity
F8G81_09285	COG0133	tryptophan synthase activity
F8G81_09290	COG0159	tryptophan synthase activity
F8G81_09295	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F8G81_09300	COG0067	glutamate synthase
F8G81_09300	COG0069	glutamate synthase activity
F8G81_09300	COG0070	glutamate synthase
F8G81_09310	COG0469	pyruvate kinase activity
F8G81_09380	COG3118	belongs to the thioredoxin family
F8G81_09390	COG0604	alcohol dehydrogenase
F8G81_09400	COG1454	alcohol dehydrogenase
F8G81_09405	COG0583	DNA-binding transcription factor activity
F8G81_09410	COG0477	Major facilitator Superfamily
F8G81_09425	COG1024	Enoyl-CoA hydratase
F8G81_09435	COG0563	adenylate kinase activity
F8G81_09515	COG0463	Glycosyl transferase, family 2
F8G81_09530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F8G81_09555	COG0477	Major facilitator Superfamily
F8G81_09570	COG2814	Major facilitator Superfamily
F8G81_09585	COG1802	Transcriptional regulator
F8G81_09590	COG1309	transcriptional regulator
F8G81_09595	COG1024	Enoyl-CoA hydratase
F8G81_09595	COG1250	3-hydroxyacyl-CoA dehydrogenase
F8G81_09600	COG0183	Belongs to the thiolase family
F8G81_09615	COG0657	acetylesterase activity
F8G81_09680	COG0251	oxidation-reduction process
F8G81_09700	COG1846	Transcriptional regulator
F8G81_09710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F8G81_09740	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_09745	COG0747	negative chemotaxis
F8G81_09750	COG0154	amidase activity
F8G81_09755	COG0601	transmembrane transport
F8G81_09760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8G81_09770	COG4608	Belongs to the ABC transporter superfamily
F8G81_09780	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_09790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F8G81_09790	COG0473	3-isopropylmalate dehydrogenase activity
F8G81_09795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F8G81_09805	COG2159	amidohydrolase
F8G81_09810	COG3384	dioxygenase
F8G81_09840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8G81_09850	COG1053	succinate dehydrogenase
F8G81_09875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F8G81_09900	COG0477	Major facilitator Superfamily
F8G81_09905	COG0154	amidase activity
F8G81_09925	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F8G81_09955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F8G81_09995	COG1733	regulation of RNA biosynthetic process
F8G81_10015	COG0583	DNA-binding transcription factor activity
F8G81_10025	COG0765	amino acid transport
F8G81_10030	COG0765	amino acid transport
F8G81_10040	COG0277	FAD linked oxidase domain protein
F8G81_10045	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_10080	COG1937	Protein conserved in bacteria
F8G81_10085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F8G81_10110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8G81_10120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8G81_10125	COG1309	transcriptional regulator
F8G81_10140	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F8G81_10145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F8G81_10150	COG0531	amino acid
F8G81_10160	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_10165	COG0686	Belongs to the AlaDH PNT family
F8G81_10170	COG2873	o-acetylhomoserine
F8G81_10175	COG1476	TRANSCRIPTIONal
F8G81_10190	COG0477	Major facilitator Superfamily
F8G81_10205	COG1309	transcriptional regulator
F8G81_10210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F8G81_10235	COG1175	transmembrane transport
F8G81_10240	COG0395	ABC-type sugar transport system, permease component
F8G81_10245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8G81_10265	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_10270	COG4948	Mandelate Racemase Muconate Lactonizing
F8G81_10280	COG3618	amidohydrolase
F8G81_10300	COG0395	ABC-type sugar transport system, permease component
F8G81_10305	COG1175	transmembrane transport
F8G81_10315	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_10320	COG1063	alcohol dehydrogenase
F8G81_10345	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_10365	COG0477	Major facilitator Superfamily
F8G81_10390	COG4608	Belongs to the ABC transporter superfamily
F8G81_10395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8G81_10400	COG2902	Dehydrogenase
F8G81_10410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F8G81_10420	COG3654	unkown
F8G81_10430	COG2072	flavoprotein involved in K transport
F8G81_10440	COG1063	alcohol dehydrogenase
F8G81_10450	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F8G81_10455	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F8G81_10460	COG0563	adenylate kinase activity
F8G81_10465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F8G81_10485	COG0477	Major facilitator Superfamily
F8G81_10490	COG1574	metal-dependent hydrolase with the TIM-barrel fold
F8G81_10545	COG0583	DNA-binding transcription factor activity
F8G81_10550	COG2186	Transcriptional regulator
F8G81_10560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8G81_10575	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_10580	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_10605	COG2133	pyrroloquinoline quinone binding
F8G81_10620	COG1063	alcohol dehydrogenase
F8G81_10630	COG0477	Major facilitator Superfamily
F8G81_10640	COG2814	Major facilitator Superfamily
F8G81_10660	COG4989	oxidoreductase activity
F8G81_10670	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F8G81_10685	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_10720	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_10730	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_10760	COG1129	ABC transporter
F8G81_10775	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_10795	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_10810	COG0300	oxidoreductase activity
F8G81_10815	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_10835	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_10845	COG1802	Transcriptional regulator
F8G81_10860	COG1063	alcohol dehydrogenase
F8G81_10895	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F8G81_10910	COG0765	amino acid transport
F8G81_10915	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_10920	COG1126	abc transporter atp-binding protein
F8G81_10925	COG1126	abc transporter atp-binding protein
F8G81_10930	COG1053	succinate dehydrogenase
F8G81_10935	COG1234	tRNA 3'-trailer cleavage
F8G81_10940	COG0028	Belongs to the TPP enzyme family
F8G81_10955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8G81_10980	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_11025	COG1609	Transcriptional regulator
F8G81_11030	COG2814	Major facilitator Superfamily
F8G81_11045	COG1024	Enoyl-CoA hydratase
F8G81_11045	COG1250	3-hydroxyacyl-CoA dehydrogenase
F8G81_11050	COG0183	Belongs to the thiolase family
F8G81_11065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8G81_11070	COG1414	Transcriptional regulator
F8G81_11080	COG4176	ABC-type proline glycine betaine transport system permease component
F8G81_11170	COG2271	Major facilitator Superfamily
F8G81_11180	COG0251	oxidation-reduction process
F8G81_11190	COG1129	ABC transporter
F8G81_11195	COG1082	Xylose isomerase domain protein TIM barrel
F8G81_11210	COG1172	Belongs to the binding-protein-dependent transport system permease family
F8G81_11220	COG0673	inositol 2-dehydrogenase activity
F8G81_11225	COG1940	carbohydrate kinase activity
F8G81_11235	COG0464	growth
F8G81_11240	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_11255	COG1053	succinate dehydrogenase
F8G81_11265	COG0028	Belongs to the TPP enzyme family
F8G81_11270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8G81_11280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F8G81_11295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F8G81_11295	COG1116	anion transmembrane transporter activity
F8G81_11300	COG0028	Belongs to the TPP enzyme family
F8G81_11310	COG3119	arylsulfatase activity
F8G81_11315	COG1309	transcriptional regulator
F8G81_11330	COG0444	Belongs to the ABC transporter superfamily
F8G81_11350	COG3119	arylsulfatase activity
F8G81_11355	COG3119	arylsulfatase activity
F8G81_11375	COG0444	Belongs to the ABC transporter superfamily
F8G81_11390	COG3119	arylsulfatase activity
F8G81_11395	COG3119	arylsulfatase activity
F8G81_11405	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F8G81_11415	COG2084	Dehydrogenase
F8G81_11420	COG1082	Xylose isomerase domain protein TIM barrel
F8G81_11425	COG0149	triose-phosphate isomerase activity
F8G81_11430	COG0698	ribose 5-phosphate isomerase
F8G81_11435	COG2376	Dihydroxyacetone kinase
F8G81_11445	COG2186	Transcriptional regulator
F8G81_11455	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_11460	COG2873	o-acetylhomoserine
F8G81_11470	COG1121	(ABC) transporter
F8G81_11475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F8G81_11485	COG0803	Belongs to the bacterial solute-binding protein 9 family
F8G81_11495	COG1414	Transcriptional regulator
F8G81_11500	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_11515	COG1175	transmembrane transport
F8G81_11520	COG0395	ABC-type sugar transport system, permease component
F8G81_11530	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
F8G81_11535	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
F8G81_11540	COG0800	Aldolase
F8G81_11550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F8G81_11560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F8G81_11570	COG0444	Belongs to the ABC transporter superfamily
F8G81_11575	COG4608	Belongs to the ABC transporter superfamily
F8G81_11600	COG1335	isochorismatase
F8G81_11645	COG0402	S-adenosylhomocysteine deaminase activity
F8G81_11655	COG0154	amidase activity
F8G81_11665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F8G81_11680	COG1960	acyl-CoA dehydrogenase activity
F8G81_11695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F8G81_11705	COG1414	Transcriptional regulator
F8G81_11710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F8G81_11715	COG0303	'Molybdopterin
F8G81_11720	COG1063	alcohol dehydrogenase
F8G81_11730	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F8G81_11735	COG3404	Formiminotransferase-cyclodeaminase
F8G81_11755	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F8G81_11780	COG1760	l-serine dehydratase
F8G81_11795	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F8G81_11805	COG0300	oxidoreductase activity
F8G81_11835	COG2814	Major facilitator Superfamily
F8G81_11845	COG0477	Major facilitator Superfamily
F8G81_11875	COG1309	transcriptional regulator
F8G81_11900	COG1309	transcriptional regulator
F8G81_11905	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_11950	COG3226	Transcriptional regulator
F8G81_11975	COG1063	alcohol dehydrogenase
F8G81_11985	COG0028	Belongs to the TPP enzyme family
F8G81_11990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F8G81_12000	COG2159	amidohydrolase
F8G81_12035	COG1414	Transcriptional regulator
F8G81_12040	COG4604	ABC transporter, ATP-binding protein
F8G81_12045	COG4605	iron ion homeostasis
F8G81_12050	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8G81_12060	COG1309	transcriptional regulator
F8G81_12090	COG2197	response regulator
F8G81_12095	COG1309	transcriptional regulator
F8G81_12110	COG2159	amidohydrolase
F8G81_12120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F8G81_12150	COG1129	ABC transporter
F8G81_12155	COG1172	Belongs to the binding-protein-dependent transport system permease family
F8G81_12160	COG2259	Doxx family
F8G81_12190	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_12205	COG2814	Major facilitator Superfamily
F8G81_12210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8G81_12220	COG4941	Belongs to the sigma-70 factor family
F8G81_12225	COG3795	YCII-related domain
F8G81_12250	COG1609	Transcriptional regulator
F8G81_12265	COG1175	transmembrane transport
F8G81_12270	COG0395	ABC-type sugar transport system, permease component
F8G81_12290	COG3552	Protein containing von Willebrand factor type A (VWA) domain
F8G81_12300	COG0714	Associated with various cellular activities
F8G81_12325	COG2124	cytochrome p450
F8G81_12330	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F8G81_12340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F8G81_12350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F8G81_12355	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F8G81_12375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8G81_12380	COG2814	Major facilitator Superfamily
F8G81_12415	COG2186	Transcriptional regulator
F8G81_12425	COG0405	Gamma-glutamyltransferase
F8G81_12430	COG3387	PFAM Glycoside hydrolase 15-related
F8G81_12450	COG0601	transmembrane transport
F8G81_12455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8G81_12460	COG4172	Belongs to the ABC transporter superfamily
F8G81_12495	COG1643	Atp-dependent helicase
F8G81_12520	COG0009	L-threonylcarbamoyladenylate synthase
F8G81_12555	COG2050	protein possibly involved in aromatic compounds catabolism
F8G81_12590	COG4552	Acetyltransferase involved in intracellular survival and related
F8G81_12595	COG0539	negative regulation of cytoplasmic translation
F8G81_12605	COG1739	Uncharacterized protein family UPF0029
F8G81_12610	COG0237	dephospho-CoA kinase activity
F8G81_12610	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
F8G81_12615	COG0556	nucleotide-excision repair
F8G81_12625	COG0477	Major facilitator Superfamily
F8G81_12650	COG4106	trans-aconitate 2-methyltransferase activity
F8G81_12675	COG0546	phosphoglycolate phosphatase activity
F8G81_12685	COG0322	excinuclease ABC activity
F8G81_12690	COG1660	Displays ATPase and GTPase activities
F8G81_12700	COG1481	regulation of sporulation
F8G81_12705	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F8G81_12710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F8G81_12715	COG0126	phosphoglycerate kinase activity
F8G81_12720	COG0149	triose-phosphate isomerase activity
F8G81_12725	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F8G81_12735	COG0363	glucosamine-6-phosphate deaminase activity
F8G81_12750	COG0166	Belongs to the GPI family
F8G81_12755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F8G81_12765	COG0109	protoheme IX farnesyltransferase activity
F8G81_12770	COG1612	heme a metabolic process
F8G81_12780	COG1131	(ABC) transporter
F8G81_12795	COG0719	Fe-S assembly protein
F8G81_12805	COG0396	ATPase activity
F8G81_12810	COG2151	metal-sulfur cluster biosynthetic enzyme
F8G81_12820	COG0318	PFAM AMP-dependent synthetase and ligase
F8G81_12835	COG1122	ATPase activity
F8G81_12840	COG1268	BioY protein
F8G81_12855	COG0488	(ABC) transporter
F8G81_12880	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_12890	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_12895	COG3830	Belongs to the UPF0237 family
F8G81_12895	COG0560	Phosphoserine phosphatase
F8G81_12900	COG1119	ATPase activity
F8G81_12935	COG0254	rRNA binding
F8G81_12950	COG2855	membrane
F8G81_12980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F8G81_12985	COG0297	glycogen (starch) synthase activity
F8G81_13005	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_13025	COG0435	Glutathione S-transferase
F8G81_13050	COG1234	tRNA 3'-trailer cleavage
F8G81_13055	COG3152	Membrane
F8G81_13065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F8G81_13085	COG0667	Aldo Keto reductase
F8G81_13090	COG1968	undecaprenyl-diphosphatase activity
F8G81_13095	COG0215	cysteine-tRNA ligase activity
F8G81_13105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F8G81_13110	COG1994	Peptidase M50
F8G81_13110	COG0517	IMP dehydrogenase activity
F8G81_13120	COG1222	aaa ATPase
F8G81_13125	COG4122	O-methyltransferase activity
F8G81_13135	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F8G81_13140	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F8G81_13145	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F8G81_13150	COG0545	Peptidyl-prolyl cis-trans isomerase
F8G81_13170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F8G81_13175	COG0805	protein transport
F8G81_13180	COG4581	dead DEAH box helicase
F8G81_13185	COG1574	metal-dependent hydrolase with the TIM-barrel fold
F8G81_13190	COG1216	Glycosyl transferase, family 2
F8G81_13215	COG0242	peptide deformylase activity
F8G81_13225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8G81_13235	COG3424	synthase
F8G81_13250	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F8G81_13255	COG4974	Belongs to the 'phage' integrase family
F8G81_13285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F8G81_13320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F8G81_13325	COG1845	cytochrome c oxidase, subunit III
F8G81_13330	COG2010	Cytochrome c
F8G81_13335	COG0723	plastoquinol--plastocyanin reductase activity
F8G81_13340	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F8G81_13350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8G81_13360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F8G81_13365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F8G81_13385	COG0167	dihydroorotate dehydrogenase activity
F8G81_13400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F8G81_13405	COG1381	Involved in DNA repair and RecF pathway recombination
F8G81_13410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F8G81_13415	COG3590	peptidase
F8G81_13420	COG1316	TRANSCRIPTIONal
F8G81_13425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F8G81_13435	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F8G81_13455	COG0484	heat shock protein binding
F8G81_13460	COG1420	regulation of RNA biosynthetic process
F8G81_13480	COG0481	GTPase activity
F8G81_13490	COG0268	Binds directly to 16S ribosomal RNA
F8G81_13510	COG1819	glycosyl
F8G81_13530	COG1307	EDD domain protein, DegV family
F8G81_13535	COG0495	leucyl-tRNA aminoacylation
F8G81_13540	COG3848	Pyruvate phosphate dikinase
F8G81_13540	COG0574	Belongs to the PEP-utilizing enzyme family
F8G81_13545	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F8G81_13550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F8G81_13555	COG2390	Transcriptional regulator
F8G81_13560	COG0656	L-ascorbic acid biosynthetic process
F8G81_13570	COG0438	transferase activity, transferring glycosyl groups
F8G81_13580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F8G81_13590	COG1758	RNA polymerase activity
F8G81_13595	COG0194	GDP metabolic process
F8G81_13600	COG0194	GDP metabolic process
F8G81_13605	COG0284	orotidine-5'-phosphate decarboxylase activity
F8G81_13610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F8G81_13615	COG0505	Belongs to the CarA family
F8G81_13625	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F8G81_13630	COG0540	Belongs to the ATCase OTCase family
F8G81_13635	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F8G81_13655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F8G81_13660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F8G81_13670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F8G81_13675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F8G81_13680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F8G81_13685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F8G81_13700	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F8G81_13715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F8G81_13735	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F8G81_13745	COG0124	histidyl-tRNA synthetase
F8G81_13750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F8G81_13755	COG1196	nuclear chromosome segregation
F8G81_13765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F8G81_13770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F8G81_13775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F8G81_13785	COG2255	four-way junction helicase activity
F8G81_13790	COG0632	four-way junction helicase activity
F8G81_13795	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F8G81_13800	COG0217	transcriptional regulatory protein
F8G81_13805	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F8G81_13810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F8G81_13825	COG0339	signal peptide processing
F8G81_13830	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F8G81_13835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F8G81_13845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F8G81_13850	COG0587	DNA-directed DNA polymerase activity
F8G81_13865	COG0077	Prephenate dehydratase
F8G81_13865	COG1605	Chorismate mutase
F8G81_13875	COG2135	peptidase activity
F8G81_13900	COG2318	DinB family
F8G81_13910	COG5006	permease, DMT superfamily
F8G81_13930	COG2813	Specifically methylates the guanine in position
F8G81_13950	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_13995	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F8G81_14000	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F8G81_14000	COG2755	lipolytic protein G-D-S-L family
F8G81_14030	COG4804	nuclease activity
F8G81_14055	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F8G81_14060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F8G81_14065	COG1780	Probably involved in ribonucleotide reductase function
F8G81_14075	COG0583	DNA-binding transcription factor activity
F8G81_14085	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F8G81_14120	COG0714	Associated with various cellular activities
F8G81_14135	COG1175	transmembrane transport
F8G81_14150	COG2813	Specifically methylates the guanine in position
F8G81_14155	COG0492	ferredoxin-NADP+ reductase activity
F8G81_14160	COG2824	Alkylphosphonate utilization operon protein PhnA
F8G81_14165	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F8G81_14185	COG0799	negative regulation of ribosome biogenesis
F8G81_14195	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F8G81_14205	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F8G81_14210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F8G81_14215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F8G81_14220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F8G81_14225	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F8G81_14230	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
F8G81_14230	COG0352	thiamine-phosphate diphosphorylase activity
F8G81_14230	COG0351	phosphomethylpyrimidine kinase
F8G81_14235	COG1530	ribonuclease E activity
F8G81_14245	COG0105	UTP biosynthetic process
F8G81_14255	COG0285	dihydrofolate synthase activity
F8G81_14260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F8G81_14280	COG0525	valine-tRNA ligase activity
F8G81_14285	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F8G81_14290	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F8G81_14295	COG0740	serine-type endopeptidase activity
F8G81_14300	COG0740	serine-type endopeptidase activity
F8G81_14305	COG0544	peptidyl-prolyl cis-trans isomerase activity
F8G81_14355	COG0668	transmembrane transport
F8G81_14370	COG1946	Acyl-CoA thioesterase
F8G81_14385	COG0629	single-stranded DNA binding
F8G81_14400	COG2115	Belongs to the xylose isomerase family
F8G81_14405	COG1070	Carbohydrate kinase
F8G81_14420	COG0673	inositol 2-dehydrogenase activity
F8G81_14430	COG0657	acetylesterase activity
F8G81_14430	COG2755	lipolytic protein G-D-S-L family
F8G81_14445	COG2017	converts alpha-aldose to the beta-anomer
F8G81_14475	COG0242	peptide deformylase activity
F8G81_14500	COG3022	response to hydroperoxide
F8G81_14510	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F8G81_14515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F8G81_14525	COG1045	serine acetyltransferase
F8G81_14530	COG0300	oxidoreductase activity
F8G81_14535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F8G81_14545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8G81_14550	COG0477	Major facilitator Superfamily
F8G81_14555	COG1414	Transcriptional regulator
F8G81_14585	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F8G81_14600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F8G81_14605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F8G81_14620	COG4974	Belongs to the 'phage' integrase family
F8G81_14635	COG0792	nuclease activity
F8G81_14645	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F8G81_14655	COG0681	Belongs to the peptidase S26 family
F8G81_14660	COG0335	large ribosomal subunit rRNA binding
F8G81_14665	COG0336	Belongs to the RNA methyltransferase TrmD family
F8G81_14670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F8G81_14675	COG1837	Belongs to the UPF0109 family
F8G81_14680	COG0228	four-way junction DNA binding
F8G81_14690	COG2514	catechol 2,3-dioxygenase activity
F8G81_14720	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F8G81_14760	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F8G81_14765	COG0571	ribonuclease III activity
F8G81_14770	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F8G81_14780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F8G81_14795	COG0742	ribosomal rna small subunit methyltransferase
F8G81_14820	COG1181	Belongs to the D-alanine--D-alanine ligase family
F8G81_14825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F8G81_14835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F8G81_14840	COG0066	3-isopropylmalate dehydratase activity
F8G81_14845	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F8G81_14850	COG1414	Transcriptional regulator
F8G81_14885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F8G81_14890	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_14895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8G81_14905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F8G81_14910	COG0473	3-isopropylmalate dehydrogenase activity
F8G81_14930	COG0577	efflux transmembrane transporter activity
F8G81_14930	COG1136	(ABC) transporter
F8G81_14940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8G81_14945	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F8G81_14950	COG0440	acetolactate synthase activity
F8G81_14960	COG0129	dihydroxy-acid dehydratase activity
F8G81_14965	COG0583	DNA-binding transcription factor activity
F8G81_14990	COG3655	Transcriptional regulator
F8G81_15000	COG1045	serine acetyltransferase
F8G81_15025	COG0747	negative chemotaxis
F8G81_15030	COG0579	oxidoreductase
F8G81_15035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F8G81_15045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8G81_15055	COG1305	Transglutaminase-like
F8G81_15085	COG1104	cysteine desulfurase activity
F8G81_15095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F8G81_15100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F8G81_15110	COG1113	amino acid transport
F8G81_15145	COG1414	Transcriptional regulator
F8G81_15155	COG0419	ATPase involved in DNA repair
F8G81_15160	COG0420	3'-5' exonuclease activity
F8G81_15185	COG0586	Pfam SNARE associated Golgi protein
F8G81_15190	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F8G81_15195	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F8G81_15200	COG1234	tRNA 3'-trailer cleavage
F8G81_15205	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F8G81_15215	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F8G81_15225	COG1335	isochorismatase
F8G81_15240	COG0363	glucosamine-6-phosphate deaminase activity
F8G81_15255	COG1902	pentaerythritol trinitrate reductase activity
F8G81_15270	COG0628	permease
F8G81_15285	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
F8G81_15295	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F8G81_15300	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F8G81_15310	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F8G81_15315	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F8G81_15320	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F8G81_15325	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F8G81_15330	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F8G81_15335	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F8G81_15340	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F8G81_15345	COG0356	it plays a direct role in the translocation of protons across the membrane
F8G81_15360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F8G81_15365	COG1216	Glycosyl transferase, family 2
F8G81_15380	COG2890	protein-(glutamine-N5) methyltransferase activity
F8G81_15385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F8G81_15395	COG0083	homoserine kinase activity
F8G81_15400	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F8G81_15405	COG0460	homoserine dehydrogenase
F8G81_15410	COG0019	diaminopimelate decarboxylase activity
F8G81_15415	COG0018	arginyl-trna synthetase
F8G81_15460	COG1643	Atp-dependent helicase
F8G81_15465	COG0537	adenosine 5'-monophosphoramidase activity
F8G81_15470	COG1064	alcohol dehydrogenase
F8G81_15485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F8G81_15500	COG1121	(ABC) transporter
F8G81_15520	COG0508	dehydrogenase complex catalyzes the overall conversion of
F8G81_15520	COG0567	Dehydrogenase, E1 component
F8G81_15545	COG1595	DNA-templated transcription, initiation
F8G81_15555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F8G81_15565	COG0483	inositol monophosphate 1-phosphatase activity
F8G81_15570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F8G81_15585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F8G81_15590	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F8G81_15610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F8G81_15620	COG2177	Part of the ABC transporter FtsEX involved in
F8G81_15625	COG2884	Cell division ATP-binding protein ftsE
F8G81_15630	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F8G81_15710	COG1088	dTDP-glucose 4,6-dehydratase activity
F8G81_15715	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F8G81_15735	COG0463	Glycosyl transferase, family 2
F8G81_15750	COG1215	transferase activity, transferring glycosyl groups
F8G81_15770	COG1216	Glycosyl transferase, family 2
F8G81_15785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F8G81_15815	COG2902	Dehydrogenase
F8G81_15850	COG0653	protein targeting
F8G81_15855	COG3214	Protein conserved in bacteria
F8G81_15860	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F8G81_15870	COG5401	PFAM Sporulation and spore germination
F8G81_15900	COG0714	Associated with various cellular activities
F8G81_15925	COG0482	sulfurtransferase activity
F8G81_15955	COG0477	Major facilitator Superfamily
F8G81_15960	COG0484	heat shock protein binding
F8G81_15965	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F8G81_15970	COG1595	DNA-templated transcription, initiation
F8G81_15985	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F8G81_15990	COG2086	electron transfer activity
F8G81_15995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F8G81_16005	COG1842	Phage shock protein A
F8G81_16025	COG1615	UPF0182 protein
F8G81_16030	COG3480	Lon protease (S16) C-terminal proteolytic domain
F8G81_16050	COG2816	NAD+ diphosphatase activity
F8G81_16080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8G81_16085	COG0765	amino acid transport
F8G81_16090	COG1126	abc transporter atp-binding protein
F8G81_16095	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F8G81_16100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8G81_16115	COG0181	hydroxymethylbilane synthase activity
F8G81_16120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F8G81_16125	COG3253	May function as heme-dependent peroxidase
F8G81_16135	COG1231	oxidoreductase activity
F8G81_16140	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F8G81_16145	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F8G81_16170	COG2154	pterin-4-alpha-carbinolamine dehydratase
F8G81_16175	COG2022	thiamine diphosphate biosynthetic process
F8G81_16185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8G81_16185	COG2022	thiamine diphosphate biosynthetic process
F8G81_16190	COG0352	thiamine-phosphate diphosphorylase activity
F8G81_16200	COG0513	Belongs to the DEAD box helicase family
F8G81_16205	COG2189	Belongs to the N(4) N(6)-methyltransferase family
F8G81_16215	COG0006	proline dipeptidase activity
F8G81_16225	COG2239	Acts as a magnesium transporter
F8G81_16240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F8G81_16250	COG1595	DNA-templated transcription, initiation
F8G81_16275	COG1611	Belongs to the LOG family
F8G81_16280	COG1126	abc transporter atp-binding protein
F8G81_16285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8G81_16290	COG0765	amino acid transport
F8G81_16295	COG0765	amino acid transport
F8G81_16300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F8G81_16305	COG2171	N-acyltransferase activity
F8G81_16320	COG3226	Transcriptional regulator
F8G81_16325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F8G81_16355	COG1217	gtp-binding protein TYPA
F8G81_16370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8G81_16380	COG0747	negative chemotaxis
F8G81_16395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8G81_16400	COG1116	anion transmembrane transporter activity
F8G81_16405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8G81_16410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8G81_16415	COG0667	Aldo Keto reductase
F8G81_16520	COG0012	GTP binding
F8G81_16530	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F8G81_16540	COG1570	exodeoxyribonuclease VII activity
F8G81_16545	COG1722	exodeoxyribonuclease VII activity
F8G81_16550	COG2326	polyphosphate kinase activity
F8G81_16570	COG2971	BadF BadG BcrA BcrD
F8G81_16575	COG0583	DNA-binding transcription factor activity
F8G81_16580	COG2814	Major facilitator Superfamily
F8G81_16605	COG0598	Magnesium transport protein CorA
F8G81_16615	COG0436	Aminotransferase
F8G81_16640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F8G81_16665	COG0519	Catalyzes the synthesis of GMP from XMP
F8G81_16665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F8G81_16685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F8G81_16690	COG0516	GMP reductase activity
F8G81_16715	COG1132	(ABC) transporter
F8G81_16725	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F8G81_16725	COG2755	lipolytic protein G-D-S-L family
F8G81_16730	COG2072	flavoprotein involved in K transport
F8G81_16735	COG2197	response regulator
F8G81_16740	COG1793	dna ligase
F8G81_16750	COG0459	protein refolding
F8G81_16755	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F8G81_16770	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F8G81_16780	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F8G81_16785	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F8G81_16790	COG0456	acetyltransferase
F8G81_16800	COG0802	atpase or kinase
F8G81_16805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F8G81_16815	COG1486	melibiose metabolic process
F8G81_16825	COG0438	transferase activity, transferring glycosyl groups
F8G81_16830	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F8G81_16845	COG0667	Aldo Keto reductase
F8G81_16870	COG0736	holo-[acyl-carrier-protein] synthase activity
F8G81_16880	COG1072	(Pantothenic acid kinase))
F8G81_16885	COG1876	peptidase activity
F8G81_16890	COG1970	mechanosensitive ion channel activity
F8G81_16895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F8G81_16900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F8G81_16905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F8G81_16910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F8G81_16915	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
F8G81_16945	COG0455	bacterial-type flagellum organization
F8G81_16985	COG1192	Involved in chromosome partitioning
F8G81_17020	COG0101	tRNA pseudouridine synthase activity
F8G81_17025	COG0203	ribosomal protein L17
F8G81_17030	COG0202	RNA polymerase activity
F8G81_17035	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F8G81_17040	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F8G81_17045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F8G81_17050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F8G81_17055	COG3191	aminopeptidase activity
F8G81_17070	COG0318	PFAM AMP-dependent synthetase and ligase
F8G81_17080	COG0463	Glycosyl transferase, family 2
F8G81_17090	COG0563	adenylate kinase activity
F8G81_17100	COG0200	Binds to the 23S rRNA
F8G81_17105	COG1841	ribosomal large subunit assembly
F8G81_17110	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F8G81_17120	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F8G81_17125	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F8G81_17130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F8G81_17135	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F8G81_17140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F8G81_17145	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F8G81_17150	COG0255	Belongs to the universal ribosomal protein uL29 family
F8G81_17155	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F8G81_17160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F8G81_17165	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F8G81_17170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F8G81_17175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F8G81_17180	COG0089	rRNA binding
F8G81_17185	COG0088	Forms part of the polypeptide exit tunnel
F8G81_17190	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F8G81_17195	COG0051	transcription antitermination factor activity, RNA binding
F8G81_17210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F8G81_17215	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F8G81_17220	COG0049	tRNA binding
F8G81_17225	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F8G81_17230	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F8G81_17235	COG0085	RNA polymerase activity
F8G81_17240	COG0183	Belongs to the thiolase family
F8G81_17245	COG0442	prolyl-tRNA aminoacylation
F8G81_17250	COG0222	ribosome binding
F8G81_17255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F8G81_17270	COG0081	regulation of translation
F8G81_17275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F8G81_17285	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F8G81_17295	COG0436	Aminotransferase
F8G81_17305	COG2197	response regulator
F8G81_17345	COG2197	response regulator
F8G81_17365	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8G81_17370	COG3485	protocatechuate 3,4-dioxygenase
F8G81_17380	COG0745	RESPONSE REGULATOR receiver
F8G81_17385	COG0456	acetyltransferase
F8G81_17390	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F8G81_17410	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F8G81_17450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F8G81_17470	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F8G81_17480	COG2030	dehydratase
F8G81_17490	COG0659	secondary active sulfate transmembrane transporter activity
F8G81_17510	COG4989	oxidoreductase activity
F8G81_17515	COG0366	Alpha amylase catalytic
F8G81_17520	COG1940	carbohydrate kinase activity
F8G81_17525	COG0702	epimerase
F8G81_17535	COG0706	membrane insertase activity
F8G81_17590	COG0754	glutathionylspermidine amidase activity
F8G81_17605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F8G81_17610	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_17615	COG5650	phosphatidylinositol metabolic process
F8G81_17620	COG1051	belongs to the nudix hydrolase family
F8G81_17655	COG2197	response regulator
F8G81_17670	COG2132	Multicopper oxidase
F8G81_17675	COG0318	PFAM AMP-dependent synthetase and ligase
F8G81_17685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8G81_17690	COG1131	(ABC) transporter
F8G81_17710	COG1388	LysM domain
F8G81_17710	COG3942	CHAP domain
F8G81_17730	COG1666	GTP binding
F8G81_17735	COG0501	Belongs to the peptidase M48B family
F8G81_17765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F8G81_17780	COG0531	amino acid
F8G81_17855	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_17875	COG2186	Transcriptional regulator
F8G81_17910	COG1648	precorrin-2 dehydrogenase activity
F8G81_17910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F8G81_17940	COG1116	anion transmembrane transporter activity
F8G81_17950	COG1690	Belongs to the RtcB family
F8G81_17975	COG0175	sulfate reduction
F8G81_17980	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F8G81_17990	COG2860	membrane
F8G81_18005	COG0142	geranyltranstransferase activity
F8G81_18015	COG2226	methyltransferase
F8G81_18020	COG1169	isochorismate synthase
F8G81_18025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8G81_18030	COG0765	amino acid transport
F8G81_18035	COG1126	abc transporter atp-binding protein
F8G81_18045	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
F8G81_18055	COG4948	Mandelate Racemase Muconate Lactonizing
F8G81_18140	COG0702	epimerase
F8G81_18200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F8G81_18200	COG2755	lipolytic protein G-D-S-L family
F8G81_18205	COG0508	dehydrogenase complex catalyzes the overall conversion of
F8G81_18210	COG0022	dehydrogenase e1 component
F8G81_18230	COG0489	protein tyrosine kinase activity
F8G81_18275	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F8G81_18295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F8G81_18300	COG1024	Enoyl-CoA hydratase
F8G81_18305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F8G81_18310	COG2151	metal-sulfur cluster biosynthetic enzyme
F8G81_18315	COG3396	Phenylacetate-CoA oxygenase
F8G81_18320	COG3460	Phenylacetate-CoA oxygenase
F8G81_18325	COG3396	Phenylacetate-CoA oxygenase
F8G81_18360	COG0640	Transcriptional regulator
F8G81_18395	COG1280	lysine exporter protein (LysE YggA)
F8G81_18425	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
F8G81_18430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8G81_18435	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8G81_18440	COG1120	ATPase activity
F8G81_18445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F8G81_18455	COG1316	TRANSCRIPTIONal
F8G81_18460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8G81_18470	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F8G81_18515	COG0667	Aldo Keto reductase
F8G81_18540	COG4213	ABC transporter substrate-binding protein
F8G81_18545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F8G81_18550	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F8G81_18560	COG0280	phosphate acetyltransferase
F8G81_18560	COG0857	belongs to the CobB CobQ family
F8G81_18570	COG2050	protein possibly involved in aromatic compounds catabolism
F8G81_18585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F8G81_18600	COG3546	catalase activity
F8G81_18605	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_18605	COG2030	dehydratase
F8G81_18610	COG2050	protein possibly involved in aromatic compounds catabolism
F8G81_18635	COG1250	3-hydroxyacyl-CoA dehydrogenase
F8G81_18640	COG1024	Enoyl-CoA hydratase
F8G81_18645	COG0183	Belongs to the thiolase family
F8G81_18660	COG3237	CsbD-like
F8G81_18685	COG2146	nitrite reductase [NAD(P)H] activity
F8G81_18690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F8G81_18700	COG0488	(ABC) transporter
F8G81_18705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F8G81_18710	COG1121	(ABC) transporter
F8G81_18720	COG1266	CAAX protease self-immunity
F8G81_18730	COG0395	ABC-type sugar transport system, permease component
F8G81_18735	COG1175	transmembrane transport
F8G81_18750	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
F8G81_18805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F8G81_18815	COG0785	Cytochrome C biogenesis protein
F8G81_18820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8G81_18825	COG0406	alpha-ribazole phosphatase activity
F8G81_18830	COG2353	YceI-like domain
F8G81_18845	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F8G81_18870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F8G81_18875	COG3458	cephalosporin-C deacetylase activity
F8G81_18880	COG1070	Carbohydrate kinase
F8G81_18885	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_18885	COG3347	Dehydrogenase
F8G81_18895	COG3254	rhamnose metabolic process
F8G81_18900	COG1609	Transcriptional regulator
F8G81_18925	COG2755	lipolytic protein G-D-S-L family
F8G81_18930	COG0673	inositol 2-dehydrogenase activity
F8G81_18950	COG0395	ABC-type sugar transport system, permease component
F8G81_18955	COG1175	transmembrane transport
F8G81_18980	COG1653	transport
F8G81_18985	COG0395	ABC-type sugar transport system, permease component
F8G81_18990	COG1175	transmembrane transport
F8G81_19000	COG0673	inositol 2-dehydrogenase activity
F8G81_19010	COG0659	secondary active sulfate transmembrane transporter activity
F8G81_19020	COG4948	Mandelate Racemase Muconate Lactonizing
F8G81_19025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8G81_19035	COG0673	inositol 2-dehydrogenase activity
F8G81_19040	COG1609	Transcriptional regulator
F8G81_19045	COG2186	Transcriptional regulator
F8G81_19060	COG0640	Transcriptional regulator
F8G81_19065	COG0123	including yeast histone deacetylase and acetoin utilization protein
F8G81_19070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F8G81_19075	COG0569	domain protein
F8G81_19080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F8G81_19085	COG0248	Ppx GppA phosphatase
F8G81_19095	COG1754	DNA topoisomerase type I activity
F8G81_19095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F8G81_19105	COG2890	protein-(glutamine-N5) methyltransferase activity
F8G81_19110	COG0789	Transcriptional regulator
F8G81_19130	COG1054	Belongs to the UPF0176 family
F8G81_19140	COG1111	helicase
F8G81_19140	COG1205	dead DEAH box helicase
F8G81_19180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F8G81_19180	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F8G81_19195	COG0494	nUDIX hydrolase
F8G81_19215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F8G81_19220	COG1349	DNA-binding transcription factor activity
F8G81_19225	COG1609	Transcriptional regulator
F8G81_19235	COG4209	transmembrane transport
F8G81_19240	COG0395	ABC-type sugar transport system, permease component
F8G81_19255	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F8G81_19280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8G81_19300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F8G81_19305	COG1408	metallophosphoesterase
F8G81_19310	COG1132	(ABC) transporter
F8G81_19315	COG1132	(ABC) transporter
F8G81_19335	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F8G81_19340	COG0151	Belongs to the GarS family
F8G81_19360	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_19375	COG0667	Aldo Keto reductase
F8G81_19380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F8G81_19390	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F8G81_19390	COG3608	succinylglutamate desuccinylase aspartoacylase
F8G81_19395	COG2252	PERMEase
F8G81_19400	COG0590	tRNA wobble adenosine to inosine editing
F8G81_19410	COG1793	dna ligase
F8G81_19410	COG3285	dna ligase
F8G81_19425	COG2233	PERMEase
F8G81_19435	COG1414	Transcriptional regulator
F8G81_19445	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F8G81_19455	COG3257	ureidoglycine aminohydrolase activity
F8G81_19465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F8G81_19475	COG3387	PFAM Glycoside hydrolase 15-related
F8G81_19500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F8G81_19510	COG0484	heat shock protein binding
F8G81_19515	COG0071	Belongs to the small heat shock protein (HSP20) family
F8G81_19520	COG0789	Transcriptional regulator
F8G81_19535	COG4335	DNA alkylation repair
F8G81_19540	COG4213	ABC transporter substrate-binding protein
F8G81_19545	COG1129	ABC transporter
F8G81_19550	COG4214	carbohydrate transport
F8G81_19575	COG0251	oxidation-reduction process
F8G81_19585	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_19590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8G81_19595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8G81_19605	COG2188	Transcriptional regulator
F8G81_19615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8G81_19620	COG0563	adenylate kinase activity
F8G81_19635	COG0346	lactoylglutathione lyase activity
F8G81_19640	COG2610	gluconate transmembrane transporter activity
F8G81_19645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8G81_19655	COG3265	gluconokinase activity
F8G81_19660	COG1063	alcohol dehydrogenase
F8G81_19665	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_19705	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_19715	COG2267	carboxylic ester hydrolase activity
F8G81_19735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8G81_19740	COG0579	oxidoreductase
F8G81_19745	COG3338	carbonate dehydratase activity
F8G81_19780	COG0583	DNA-binding transcription factor activity
F8G81_19800	COG1597	lipid kinase activity
F8G81_19810	COG0583	DNA-binding transcription factor activity
F8G81_19815	COG2828	Protein conserved in bacteria
F8G81_19830	COG0589	response to stress
F8G81_19845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8G81_19850	COG0765	amino acid transport
F8G81_19855	COG1126	abc transporter atp-binding protein
F8G81_19875	COG2186	Transcriptional regulator
F8G81_19885	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_19890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8G81_19920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F8G81_19925	COG0596	Alpha beta hydrolase
F8G81_19940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F8G81_19965	COG0024	Methionine aminopeptidase
F8G81_19980	COG2186	Transcriptional regulator
F8G81_19985	COG1027	Aspartate ammonia-lyase
F8G81_20005	COG1175	transmembrane transport
F8G81_20010	COG0395	ABC-type sugar transport system, permease component
F8G81_20015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8G81_20020	COG3507	Belongs to the glycosyl hydrolase 43 family
F8G81_20025	COG1609	Transcriptional regulator
F8G81_20030	COG3345	alpha-galactosidase
F8G81_20045	COG0563	adenylate kinase activity
F8G81_20075	COG1621	beta-fructofuranosidase activity
F8G81_20085	COG0395	ABC-type sugar transport system, permease component
F8G81_20090	COG4209	transmembrane transport
F8G81_20095	COG1609	Transcriptional regulator
F8G81_20105	COG1621	beta-fructofuranosidase activity
F8G81_20115	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
F8G81_20130	COG2202	Pas domain
F8G81_20130	COG2205	protein histidine kinase activity
F8G81_20185	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_20205	COG1126	abc transporter atp-binding protein
F8G81_20210	COG0765	amino acid transport
F8G81_20215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8G81_20230	COG2186	Transcriptional regulator
F8G81_20245	COG2326	polyphosphate kinase activity
F8G81_20295	COG0745	RESPONSE REGULATOR receiver
F8G81_20350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F8G81_20355	COG2186	Transcriptional regulator
F8G81_20360	COG0531	amino acid
F8G81_20370	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F8G81_20375	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_20380	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_20400	COG0454	-acetyltransferase
F8G81_20410	COG0583	DNA-binding transcription factor activity
F8G81_20425	COG2197	response regulator
F8G81_20445	COG3845	ABC transporter
F8G81_20450	COG1960	acyl-CoA dehydrogenase activity
F8G81_20455	COG0183	Belongs to the thiolase family
F8G81_20460	COG0318	PFAM AMP-dependent synthetase and ligase
F8G81_20465	COG1250	3-hydroxyacyl-CoA dehydrogenase
F8G81_20465	COG1024	Enoyl-CoA hydratase
F8G81_20480	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F8G81_20490	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F8G81_20495	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F8G81_20520	COG1607	acyl-coa hydrolase
F8G81_20525	COG2072	flavoprotein involved in K transport
F8G81_20530	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_20540	COG1024	Enoyl-CoA hydratase
F8G81_20545	COG0318	PFAM AMP-dependent synthetase and ligase
F8G81_20555	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F8G81_20570	COG0657	acetylesterase activity
F8G81_20580	COG1410	methionine synthase
F8G81_20580	COG0646	methionine synthase
F8G81_20615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F8G81_20625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F8G81_20630	COG0509	glycine decarboxylation via glycine cleavage system
F8G81_20635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8G81_20640	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F8G81_20640	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F8G81_20655	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
F8G81_20675	COG3268	Saccharopine dehydrogenase
F8G81_20685	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F8G81_20690	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F8G81_20695	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F8G81_20705	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F8G81_20725	COG1228	amidohydrolase
F8G81_20745	COG2814	Major facilitator Superfamily
F8G81_20755	COG0604	alcohol dehydrogenase
F8G81_20775	COG1490	D-aminoacyl-tRNA deacylase activity
F8G81_20785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8G81_20815	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_20820	COG0475	glutathione-regulated potassium exporter activity
F8G81_20945	COG3226	Transcriptional regulator
F8G81_20960	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F8G81_20980	COG4762	Protein conserved in bacteria
F8G81_21015	COG1609	Transcriptional regulator
F8G81_21025	COG1175	transmembrane transport
F8G81_21030	COG0395	ABC-type sugar transport system, permease component
F8G81_21045	COG0673	inositol 2-dehydrogenase activity
F8G81_21050	COG1609	Transcriptional regulator
F8G81_21055	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_21085	COG0745	RESPONSE REGULATOR receiver
F8G81_21105	COG0395	ABC-type sugar transport system, permease component
F8G81_21125	COG4585	Histidine kinase
F8G81_21160	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F8G81_21170	COG0673	inositol 2-dehydrogenase activity
F8G81_21180	COG0395	ABC-type sugar transport system, permease component
F8G81_21190	COG2182	Extracellular solute-binding protein
F8G81_21195	COG1609	Transcriptional regulator
F8G81_21200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F8G81_21215	COG1301	dicarboxylic acid transport
F8G81_21235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F8G81_21240	COG3622	Belongs to the hyi family
F8G81_21245	COG2084	Dehydrogenase
F8G81_21250	COG3960	tartronate-semialdehyde synthase activity
F8G81_21255	COG1929	Belongs to the glycerate kinase type-1 family
F8G81_21260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F8G81_21300	COG0745	RESPONSE REGULATOR receiver
F8G81_21310	COG1366	Belongs to the anti-sigma-factor antagonist family
F8G81_21325	COG2351	hydroxyisourate hydrolase activity
F8G81_21340	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F8G81_21395	COG3585	molybdate ion transport
F8G81_21415	COG3304	Inner membrane component domain
F8G81_21420	COG0135	phosphoribosylanthranilate isomerase activity
F8G81_21430	COG1528	Iron-storage protein
F8G81_21440	COG2076	Multidrug Resistance protein
F8G81_21445	COG0563	adenylate kinase activity
F8G81_21450	COG0667	Aldo Keto reductase
F8G81_21460	COG1131	(ABC) transporter
F8G81_21475	COG0500	methyltransferase
F8G81_21495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F8G81_21565	COG2217	Heavy metal translocating P-type atpase
F8G81_21570	COG2217	Heavy metal translocating P-type atpase
F8G81_21585	COG1131	(ABC) transporter
F8G81_21600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F8G81_21645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F8G81_21650	COG1802	Transcriptional regulator
F8G81_21665	COG3971	2-oxopent-4-enoate hydratase activity
F8G81_21680	COG0789	Transcriptional regulator
F8G81_21685	COG0484	heat shock protein binding
F8G81_21690	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F8G81_21695	COG0443	Heat shock 70 kDa protein
F8G81_21705	COG0395	ABC-type sugar transport system, permease component
F8G81_21710	COG1175	transmembrane transport
F8G81_21730	COG2409	Drug exporters of the RND superfamily
F8G81_21810	COG1280	lysine exporter protein (LysE YggA)
F8G81_21815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F8G81_21825	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F8G81_21835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F8G81_21880	COG0183	Belongs to the thiolase family
F8G81_21930	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F8G81_21935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F8G81_21950	COG1122	ATPase activity
F8G81_21955	COG4721	ABC-type cobalt transport system, permease component
F8G81_21960	COG4702	Belongs to the UPF0303 family
F8G81_21970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8G81_21990	COG3655	Transcriptional regulator
F8G81_22005	COG1320	monovalent cation:proton antiporter activity
F8G81_22010	COG2212	antiporter activity
F8G81_22015	COG1863	multisubunit Na H antiporter MnhE subunit
F8G81_22020	COG0651	ATP synthesis coupled electron transport
F8G81_22025	COG1006	Multisubunit Na H antiporter MnhC subunit
F8G81_22030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F8G81_22030	COG2111	Na H antiporter
F8G81_22040	COG0569	domain protein
F8G81_22040	COG2985	domain, Protein
F8G81_22045	COG0475	glutathione-regulated potassium exporter activity
F8G81_22055	COG0717	Belongs to the dCTP deaminase family
F8G81_22085	COG2814	Major facilitator Superfamily
F8G81_22090	COG0583	DNA-binding transcription factor activity
F8G81_22100	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_22105	COG0531	amino acid
F8G81_22115	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F8G81_22120	COG0679	Auxin Efflux Carrier
F8G81_22130	COG2814	Major facilitator Superfamily
F8G81_22135	COG3387	PFAM Glycoside hydrolase 15-related
F8G81_22140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8G81_22150	COG0433	COG0433 Predicted ATPase
F8G81_22165	COG3336	cytochrome c oxidase
F8G81_22170	COG0776	regulation of translation
F8G81_22195	COG1609	Transcriptional regulator
F8G81_22215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F8G81_22220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F8G81_22225	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F8G81_22260	COG1120	ATPase activity
F8G81_22265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8G81_22270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8G81_22315	COG3012	SEC-C Motif Domain Protein
F8G81_22325	COG0667	Aldo Keto reductase
F8G81_22330	COG0667	Aldo Keto reductase
F8G81_22375	COG3387	PFAM Glycoside hydrolase 15-related
F8G81_22380	COG2186	Transcriptional regulator
F8G81_22390	COG1027	Aspartate ammonia-lyase
F8G81_22400	COG2186	Transcriptional regulator
F8G81_22410	COG1172	Belongs to the binding-protein-dependent transport system permease family
F8G81_22435	COG4948	Mandelate Racemase Muconate Lactonizing
F8G81_22440	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_22445	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_22455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F8G81_22485	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_22495	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_22515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F8G81_22540	COG1280	lysine exporter protein (LysE YggA)
F8G81_22555	COG0281	malic enzyme
F8G81_22560	COG1309	transcriptional regulator
F8G81_22585	COG0477	Major facilitator Superfamily
F8G81_22590	COG0477	Major facilitator Superfamily
F8G81_22600	COG0246	Mannitol dehydrogenase
F8G81_22615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F8G81_22640	COG0686	Belongs to the AlaDH PNT family
F8G81_22645	COG0673	inositol 2-dehydrogenase activity
F8G81_22675	COG0431	NADPH-dependent FMN reductase
F8G81_22690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F8G81_22705	COG0508	dehydrogenase complex catalyzes the overall conversion of
F8G81_22710	COG0022	dehydrogenase e1 component
F8G81_22720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8G81_22725	COG1950	PFAM Membrane protein of
F8G81_22740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F8G81_22745	COG0406	alpha-ribazole phosphatase activity
F8G81_22755	COG1840	ABC-type Fe3 transport system, periplasmic component
F8G81_22760	COG3842	ATPase activity
F8G81_22785	COG1597	lipid kinase activity
F8G81_22815	COG1414	Transcriptional regulator
F8G81_22820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F8G81_22830	COG0183	Belongs to the thiolase family
F8G81_22835	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F8G81_22845	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F8G81_22850	COG3485	protocatechuate 3,4-dioxygenase
F8G81_22855	COG3485	protocatechuate 3,4-dioxygenase
F8G81_22860	COG3185	4-Hydroxyphenylpyruvate dioxygenase
F8G81_22860	COG1082	Xylose isomerase domain protein TIM barrel
F8G81_22865	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F8G81_22870	COG1414	Transcriptional regulator
F8G81_22885	COG1793	dna ligase
F8G81_22900	COG0366	Alpha amylase catalytic
F8G81_22920	COG1940	carbohydrate kinase activity
F8G81_22940	COG0515	serine threonine protein kinase
F8G81_22940	COG2815	serine threonine protein kinase
F8G81_22955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8G81_22960	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8G81_22965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F8G81_22970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F8G81_22985	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_22990	COG2807	transmembrane transport
F8G81_22995	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F8G81_23005	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8G81_23040	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8G81_23045	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F8G81_23075	COG1937	Protein conserved in bacteria
F8G81_23100	COG0697	spore germination
F8G81_23125	COG2259	Doxx family
F8G81_23130	COG3401	FG-GAP repeat protein
F8G81_23140	COG0305	Participates in initiation and elongation during chromosome replication
F8G81_23170	COG0359	binds to the 23S rRNA
F8G81_23175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F8G81_23185	COG0360	Binds together with S18 to 16S ribosomal RNA
F8G81_23195	COG1113	amino acid transport
F8G81_23205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F8G81_23220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F8G81_23230	COG1216	Glycosyl transferase, family 2
F8G81_23230	COG0463	Glycosyl transferase, family 2
F8G81_23245	COG1215	transferase activity, transferring glycosyl groups
F8G81_23295	COG1362	aminopeptidase activity
F8G81_23305	COG2197	response regulator
F8G81_23310	COG4585	Histidine kinase
F8G81_23320	COG1131	(ABC) transporter
F8G81_23330	COG0738	Major facilitator superfamily
F8G81_23345	COG0488	(ABC) transporter
F8G81_23355	COG1733	regulation of RNA biosynthetic process
F8G81_23360	COG2910	NAD(P)H-binding
F8G81_23380	COG0406	alpha-ribazole phosphatase activity
F8G81_23385	COG0617	tRNA 3'-terminal CCA addition
F8G81_23415	COG0492	ferredoxin-NADP+ reductase activity
F8G81_23420	COG3118	belongs to the thioredoxin family
F8G81_23430	COG1192	Involved in chromosome partitioning
F8G81_23435	COG0357	Ribosomal RNA small subunit methyltransferase G
F8G81_23445	COG0706	membrane insertase activity
F8G81_23450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F8G81_23455	COG0594	ribonuclease P activity
F8G81_23460	COG0230	Belongs to the bacterial ribosomal protein bL34 family