locus-tag	class	description
AYX22_00050	COG0768	penicillin binding
AYX22_00055	COG1501	Belongs to the glycosyl hydrolase 31 family
AYX22_00060	COG2197	response regulator
AYX22_00065	COG4585	Histidine kinase
AYX22_00075	COG1136	(ABC) transporter
AYX22_00080	COG1733	regulation of RNA biosynthetic process
AYX22_00085	COG2910	NAD(P)H-binding
AYX22_00110	COG0406	alpha-ribazole phosphatase activity
AYX22_00115	COG0617	tRNA 3'-terminal CCA addition
AYX22_00135	COG0492	ferredoxin-NADP+ reductase activity
AYX22_00140	COG3118	belongs to the thioredoxin family
AYX22_00150	COG1192	Involved in chromosome partitioning
AYX22_00155	COG0357	Ribosomal RNA small subunit methyltransferase G
AYX22_00165	COG0706	membrane insertase activity
AYX22_00170	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AYX22_00175	COG0594	ribonuclease P activity
AYX22_00180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AYX22_00185	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AYX22_00190	COG0592	DNA-directed DNA polymerase activity
AYX22_00195	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AYX22_00200	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AYX22_00205	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AYX22_00210	COG0187	DNA topoisomerase II activity
AYX22_00220	COG3266	domain, Protein
AYX22_00245	COG1215	transferase activity, transferring glycosyl groups
AYX22_00260	COG0705	Rhomboid family
AYX22_00270	COG2818	Glycosylase
AYX22_00280	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AYX22_00280	COG2169	Transcriptional regulator
AYX22_00285	COG1595	DNA-templated transcription, initiation
AYX22_00300	COG3764	Sortase (surface protein transpeptidase)
AYX22_00310	COG0515	serine threonine protein kinase
AYX22_00315	COG0515	serine threonine protein kinase
AYX22_00320	COG0768	penicillin binding
AYX22_00335	COG1716	ATPase activity
AYX22_00340	COG1716	ATPase activity
AYX22_00350	COG2188	Transcriptional regulator
AYX22_00365	COG2197	response regulator
AYX22_00370	COG4585	Histidine kinase
AYX22_00410	COG1505	serine-type exopeptidase activity
AYX22_00440	COG4988	ABC transporter
AYX22_00445	COG1132	(ABC) transporter
AYX22_00455	COG1120	ATPase activity
AYX22_00470	COG0346	lactoylglutathione lyase activity
AYX22_00485	COG2186	Transcriptional regulator
AYX22_00490	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AYX22_00500	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AYX22_00505	COG4770	biotin carboxylase activity
AYX22_00510	COG0277	FAD linked oxidase domain protein
AYX22_00520	COG0385	Bile acid
AYX22_00525	COG0659	secondary active sulfate transmembrane transporter activity
AYX22_00545	COG0435	Glutathione S-transferase
AYX22_00550	COG0561	phosphatase activity
AYX22_00575	COG3250	beta-galactosidase activity
AYX22_00580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AYX22_00585	COG1929	Belongs to the glycerate kinase type-1 family
AYX22_00620	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AYX22_00640	COG1131	(ABC) transporter
AYX22_00710	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_00715	COG1309	transcriptional regulator
AYX22_00720	COG2364	Membrane
AYX22_00730	COG1309	transcriptional regulator
AYX22_00735	COG0693	protein deglycase activity
AYX22_00755	COG2723	6-phospho-beta-galactosidase activity
AYX22_00760	COG0395	ABC-type sugar transport system, permease component
AYX22_00785	COG1131	(ABC) transporter
AYX22_00795	COG2197	response regulator
AYX22_00800	COG4585	Histidine kinase
AYX22_00815	COG0747	negative chemotaxis
AYX22_00825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AYX22_00845	COG2233	PERMEase
AYX22_00850	COG0778	Nitroreductase
AYX22_00875	COG3104	oligopeptide transport
AYX22_00885	COG3340	Belongs to the peptidase S51 family
AYX22_00890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AYX22_00890	COG0425	Belongs to the sulfur carrier protein TusA family
AYX22_00895	COG0077	Prephenate dehydratase
AYX22_00905	COG1597	lipid kinase activity
AYX22_00910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AYX22_00920	COG3973	AAA domain
AYX22_00925	COG0561	phosphatase activity
AYX22_00945	COG1191	sigma factor activity
AYX22_00955	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AYX22_00960	COG0859	PFAM glycosyl transferase family 9
AYX22_00970	COG0297	glycogen (starch) synthase activity
AYX22_00975	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AYX22_00980	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AYX22_00980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AYX22_00995	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AYX22_00995	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AYX22_01000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AYX22_01055	COG2027	D-alanyl-D-alanine carboxypeptidase
AYX22_01065	COG0037	tRNA processing
AYX22_01080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYX22_01085	COG0302	gtp cyclohydrolase
AYX22_01095	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AYX22_01125	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AYX22_01130	COG2814	Major facilitator Superfamily
AYX22_01240	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AYX22_01255	COG1819	glycosyl
AYX22_01260	COG0823	Involved in the tonB-independent uptake of proteins
AYX22_01260	COG1506	peptidase
AYX22_01265	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AYX22_01280	COG2376	Dihydroxyacetone kinase
AYX22_01285	COG1461	Dihydroxyacetone kinase
AYX22_01290	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AYX22_01290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYX22_01290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AYX22_01295	COG3237	CsbD-like
AYX22_01320	COG1301	dicarboxylic acid transport
AYX22_01335	COG1194	a g-specific adenine glycosylase
AYX22_01345	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AYX22_01360	COG3665	Urea carboxylase-associated protein
AYX22_01390	COG0671	phosphoesterase, PA-phosphatase related
AYX22_01415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AYX22_01450	COG0582	viral genome integration into host DNA
AYX22_01475	COG1846	Transcriptional regulator
AYX22_01480	COG0305	Participates in initiation and elongation during chromosome replication
AYX22_01610	COG0739	heme binding
AYX22_01710	COG4106	trans-aconitate 2-methyltransferase activity
AYX22_01750	COG3654	unkown
AYX22_01760	COG0831	urea catabolic process
AYX22_01765	COG0832	Belongs to the urease beta subunit family
AYX22_01770	COG0804	urea catabolic process
AYX22_01775	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AYX22_01780	COG0830	nickel cation binding
AYX22_01785	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AYX22_01790	COG0829	nickel cation binding
AYX22_01795	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AYX22_01805	COG1595	DNA-templated transcription, initiation
AYX22_01835	COG0656	L-ascorbic acid biosynthetic process
AYX22_01845	COG0667	Aldo Keto reductase
AYX22_01850	COG0656	L-ascorbic acid biosynthetic process
AYX22_01860	COG3360	Dodecin
AYX22_01865	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_01875	COG0028	Belongs to the TPP enzyme family
AYX22_01880	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AYX22_01885	COG1233	COG1233 Phytoene dehydrogenase and related
AYX22_01890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYX22_01915	COG2186	Transcriptional regulator
AYX22_01920	COG2267	carboxylic ester hydrolase activity
AYX22_01930	COG2084	Dehydrogenase
AYX22_01935	COG2610	gluconate transmembrane transporter activity
AYX22_01990	COG0076	glutamate decarboxylase activity
AYX22_01995	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AYX22_02040	COG0346	lactoylglutathione lyase activity
AYX22_02055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYX22_02060	COG0477	Major facilitator Superfamily
AYX22_02065	COG2890	protein-(glutamine-N5) methyltransferase activity
AYX22_02080	COG1793	dna ligase
AYX22_02080	COG3285	dna ligase
AYX22_02085	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AYX22_02125	COG3226	Transcriptional regulator
AYX22_02135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYX22_02135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AYX22_02135	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AYX22_02140	COG1105	Belongs to the carbohydrate kinase PfkB family
AYX22_02145	COG1349	DNA-binding transcription factor activity
AYX22_02165	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AYX22_02190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYX22_02210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYX22_02215	COG0765	amino acid transport
AYX22_02220	COG1126	abc transporter atp-binding protein
AYX22_02265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AYX22_02285	COG1846	Transcriptional regulator
AYX22_02310	COG0142	geranyltranstransferase activity
AYX22_02315	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AYX22_02355	COG0179	Fumarylacetoacetate (FAA) hydrolase
AYX22_02370	COG2814	Major facilitator Superfamily
AYX22_02375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYX22_02380	COG4335	DNA alkylation repair
AYX22_02390	COG0129	dihydroxy-acid dehydratase activity
AYX22_02405	COG2197	response regulator
AYX22_02440	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AYX22_02460	COG2733	membrane
AYX22_02500	COG4122	O-methyltransferase activity
AYX22_02530	COG1132	(ABC) transporter
AYX22_02535	COG1132	(ABC) transporter
AYX22_02540	COG2207	Transcriptional regulator
AYX22_02555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYX22_02560	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYX22_02565	COG1120	ATPase activity
AYX22_02580	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_02585	COG1733	regulation of RNA biosynthetic process
AYX22_02590	COG0702	epimerase
AYX22_02615	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AYX22_02635	COG2902	Dehydrogenase
AYX22_02650	COG0010	Belongs to the arginase family
AYX22_02655	COG2252	PERMEase
AYX22_02680	COG3848	Pyruvate phosphate dikinase
AYX22_02680	COG0574	Belongs to the PEP-utilizing enzyme family
AYX22_02695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AYX22_02735	COG1302	Protein conserved in bacteria
AYX22_02780	COG1653	transport
AYX22_02785	COG1175	transmembrane transport
AYX22_02790	COG0395	ABC-type sugar transport system, permease component
AYX22_02795	COG1609	Transcriptional regulator
AYX22_02815	COG2197	response regulator
AYX22_02820	COG4585	Histidine kinase
AYX22_02835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AYX22_02865	COG4585	Histidine kinase
AYX22_02880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYX22_02890	COG0303	'Molybdopterin
AYX22_02895	COG1063	alcohol dehydrogenase
AYX22_02905	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AYX22_02910	COG3404	Formiminotransferase-cyclodeaminase
AYX22_02925	COG1802	Transcriptional regulator
AYX22_02930	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AYX22_02935	COG0583	DNA-binding transcription factor activity
AYX22_02960	COG0415	Belongs to the DNA photolyase family
AYX22_02970	COG1024	Enoyl-CoA hydratase
AYX22_03015	COG0789	Transcriptional regulator
AYX22_03035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYX22_03040	COG1960	acyl-CoA dehydrogenase activity
AYX22_03055	COG1012	belongs to the aldehyde dehydrogenase family
AYX22_03065	COG1280	lysine exporter protein (LysE YggA)
AYX22_03110	COG1621	beta-fructofuranosidase activity
AYX22_03115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AYX22_03125	COG0789	Transcriptional regulator
AYX22_03140	COG1012	belongs to the aldehyde dehydrogenase family
AYX22_03145	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AYX22_03155	COG0531	amino acid
AYX22_03160	COG2186	Transcriptional regulator
AYX22_03165	COG3835	regulator
AYX22_03170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYX22_03175	COG0765	amino acid transport
AYX22_03180	COG1126	abc transporter atp-binding protein
AYX22_03190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYX22_03195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AYX22_03200	COG1609	Transcriptional regulator
AYX22_03215	COG0747	negative chemotaxis
AYX22_03225	COG0444	Belongs to the ABC transporter superfamily
AYX22_03230	COG4172	Belongs to the ABC transporter superfamily
AYX22_03240	COG0673	inositol 2-dehydrogenase activity
AYX22_03245	COG1609	Transcriptional regulator
AYX22_03250	COG1904	glucuronate isomerase
AYX22_03255	COG0246	Mannitol dehydrogenase
AYX22_03260	COG4948	Mandelate Racemase Muconate Lactonizing
AYX22_03270	COG4213	ABC transporter substrate-binding protein
AYX22_03275	COG1129	ABC transporter
AYX22_03280	COG4214	carbohydrate transport
AYX22_03285	COG1609	Transcriptional regulator
AYX22_03290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AYX22_03335	COG1120	ATPase activity
AYX22_03340	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYX22_03345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYX22_03350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AYX22_03365	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AYX22_03380	COG2814	Major facilitator Superfamily
AYX22_03400	COG1309	transcriptional regulator
AYX22_03420	COG2378	regulation of single-species biofilm formation
AYX22_03440	COG0583	DNA-binding transcription factor activity
AYX22_03445	COG0039	L-malate dehydrogenase activity
AYX22_03450	COG0477	Major facilitator Superfamily
AYX22_03455	COG2826	transposase and inactivated derivatives, IS30 family
AYX22_03460	COG2267	carboxylic ester hydrolase activity
AYX22_03470	COG3263	regulation of cellular component size
AYX22_03500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AYX22_03540	COG1832	CoA-binding protein
AYX22_03550	COG2315	Protein conserved in bacteria
AYX22_03560	COG1653	transport
AYX22_03565	COG1175	transmembrane transport
AYX22_03570	COG0395	ABC-type sugar transport system, permease component
AYX22_03590	COG2368	4-hydroxyphenylacetate
AYX22_03630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AYX22_03650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AYX22_03655	COG0047	phosphoribosylformylglycinamidine synthase activity
AYX22_03675	COG3546	catalase activity
AYX22_03680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AYX22_03710	COG1846	Transcriptional regulator
AYX22_03725	COG5416	Lipopolysaccharide assembly protein A domain
AYX22_03740	COG2814	Major facilitator Superfamily
AYX22_03770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AYX22_03785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AYX22_03800	COG1012	belongs to the aldehyde dehydrogenase family
AYX22_03820	COG0488	(ABC) transporter
AYX22_03830	COG1309	transcriptional regulator
AYX22_03835	COG0741	lytic transglycosylase activity
AYX22_03835	COG0739	heme binding
AYX22_03835	COG1196	nuclear chromosome segregation
AYX22_03840	COG0386	Belongs to the glutathione peroxidase family
AYX22_03845	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AYX22_03880	COG1609	Transcriptional regulator
AYX22_03885	COG0673	inositol 2-dehydrogenase activity
AYX22_03895	COG1609	Transcriptional regulator
AYX22_03905	COG1175	transmembrane transport
AYX22_03910	COG0395	ABC-type sugar transport system, permease component
AYX22_03925	COG0438	transferase activity, transferring glycosyl groups
AYX22_03940	COG0589	response to stress
AYX22_03965	COG3290	protein histidine kinase activity
AYX22_03970	COG4565	transcriptional regulatory protein
AYX22_03980	COG2814	Major facilitator Superfamily
AYX22_03995	COG2814	Major facilitator Superfamily
AYX22_04015	COG0039	L-malate dehydrogenase activity
AYX22_04020	COG0477	Major facilitator Superfamily
AYX22_04025	COG0154	amidase activity
AYX22_04045	COG0823	Involved in the tonB-independent uptake of proteins
AYX22_04060	COG0673	inositol 2-dehydrogenase activity
AYX22_04070	COG1846	Transcriptional regulator
AYX22_04070	COG1940	carbohydrate kinase activity
AYX22_04080	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AYX22_04090	COG1476	TRANSCRIPTIONal
AYX22_04100	COG1309	transcriptional regulator
AYX22_04110	COG0351	phosphomethylpyrimidine kinase
AYX22_04120	COG0642	Histidine kinase
AYX22_04125	COG0745	RESPONSE REGULATOR receiver
AYX22_04130	COG0477	Major facilitator Superfamily
AYX22_04145	COG1090	epimerase
AYX22_04160	COG0343	queuine tRNA-ribosyltransferase activity
AYX22_04200	COG1960	acyl-CoA dehydrogenase activity
AYX22_04250	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AYX22_04260	COG0586	Pfam SNARE associated Golgi protein
AYX22_04275	COG0564	pseudouridine synthase activity
AYX22_04305	COG2364	Membrane
AYX22_04320	COG1215	transferase activity, transferring glycosyl groups
AYX22_04330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AYX22_04335	COG1201	RNA secondary structure unwinding
AYX22_04360	COG0515	serine threonine protein kinase
AYX22_04365	COG1674	ftsk spoiiie
AYX22_04430	COG0438	transferase activity, transferring glycosyl groups
AYX22_04450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AYX22_04475	COG2205	protein histidine kinase activity
AYX22_04480	COG0745	RESPONSE REGULATOR receiver
AYX22_04490	COG2062	phosphohistidine phosphatase, SixA
AYX22_04500	COG0583	DNA-binding transcription factor activity
AYX22_04505	COG0697	spore germination
AYX22_04520	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AYX22_04530	COG0601	transmembrane transport
AYX22_04540	COG4172	Belongs to the ABC transporter superfamily
AYX22_04545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYX22_04555	COG1309	transcriptional regulator
AYX22_04560	COG1511	domain protein
AYX22_04580	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AYX22_04585	COG1940	carbohydrate kinase activity
AYX22_04595	COG4608	Belongs to the ABC transporter superfamily
AYX22_04600	COG0444	Belongs to the ABC transporter superfamily
AYX22_04610	COG0747	negative chemotaxis
AYX22_04625	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AYX22_04645	COG0514	ATP-dependent DNA helicase (RecQ)
AYX22_04650	COG2814	Major facilitator Superfamily
AYX22_04660	COG1505	serine-type exopeptidase activity
AYX22_04690	COG0604	alcohol dehydrogenase
AYX22_04690	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_04690	COG3321	synthase
AYX22_04700	COG1966	Carbon starvation protein
AYX22_04720	COG0656	L-ascorbic acid biosynthetic process
AYX22_04730	COG0154	amidase activity
AYX22_04770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AYX22_04775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AYX22_04795	COG0588	phosphoglycerate mutase activity
AYX22_04800	COG2826	transposase and inactivated derivatives, IS30 family
AYX22_04810	COG5002	protein histidine kinase activity
AYX22_04830	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AYX22_04835	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AYX22_04845	COG0215	cysteine-tRNA ligase activity
AYX22_04890	COG0577	efflux transmembrane transporter activity
AYX22_04890	COG1136	(ABC) transporter
AYX22_04900	COG0366	Alpha amylase catalytic
AYX22_04910	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AYX22_04955	COG1609	Transcriptional regulator
AYX22_04960	COG0366	Alpha amylase catalytic
AYX22_04970	COG0277	FAD linked oxidase domain protein
AYX22_04995	COG0402	S-adenosylhomocysteine deaminase activity
AYX22_05015	COG3842	ATPase activity
AYX22_05095	COG0586	Pfam SNARE associated Golgi protein
AYX22_05100	COG1609	Transcriptional regulator
AYX22_05105	COG0395	ABC-type sugar transport system, permease component
AYX22_05110	COG1175	transmembrane transport
AYX22_05125	COG1621	beta-fructofuranosidase activity
AYX22_05135	COG0514	ATP-dependent DNA helicase (RecQ)
AYX22_05140	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AYX22_05145	COG0588	phosphoglycerate mutase activity
AYX22_05180	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_05190	COG1960	acyl-CoA dehydrogenase activity
AYX22_05215	COG0579	oxidoreductase
AYX22_05240	COG2957	Belongs to the agmatine deiminase family
AYX22_05250	COG0024	Methionine aminopeptidase
AYX22_05265	COG0492	ferredoxin-NADP+ reductase activity
AYX22_05280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AYX22_05285	COG4786	Flagellar basal body rod
AYX22_05285	COG1256	bacterial-type flagellum assembly
AYX22_05295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AYX22_05325	COG1815	bacterial-type flagellum-dependent cell motility
AYX22_05335	COG1677	Flagellar hook-basal body complex protein FliE
AYX22_05340	COG1766	The M ring may be actively involved in energy transduction
AYX22_05345	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AYX22_05355	COG1157	protein secretion by the type III secretion system
AYX22_05365	COG0791	NLP P60 protein
AYX22_05375	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AYX22_05390	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AYX22_05395	COG1360	Flagellar Motor Protein
AYX22_05415	COG1338	Plays a role in the flagellum-specific transport system
AYX22_05430	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AYX22_05435	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AYX22_05445	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AYX22_05465	COG0477	Major facilitator Superfamily
AYX22_05475	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AYX22_05475	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AYX22_05480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AYX22_05485	COG0509	glycine decarboxylation via glycine cleavage system
AYX22_05495	COG1864	DNA RNA non-specific endonuclease
AYX22_05495	COG3591	Belongs to the peptidase S1B family
AYX22_05585	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AYX22_05605	COG0459	protein refolding
AYX22_05610	COG0328	RNA-DNA hybrid ribonuclease activity
AYX22_05620	COG2205	protein histidine kinase activity
AYX22_05625	COG0745	RESPONSE REGULATOR receiver
AYX22_05635	COG0583	DNA-binding transcription factor activity
AYX22_05645	COG2132	Multicopper oxidase
AYX22_05670	COG1278	Cold shock
AYX22_05680	COG2814	Major facilitator Superfamily
AYX22_05685	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AYX22_05695	COG0739	heme binding
AYX22_05700	COG0791	NLP P60 protein
AYX22_05700	COG1388	LysM domain
AYX22_05700	COG3103	Sh3 type 3 domain protein
AYX22_05715	COG0746	molybdenum cofactor guanylyltransferase activity
AYX22_05730	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AYX22_05750	COG1126	abc transporter atp-binding protein
AYX22_05755	COG0765	amino acid transport
AYX22_05760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYX22_05775	COG0488	(ABC) transporter
AYX22_05780	COG1132	(ABC) transporter
AYX22_05785	COG0494	nUDIX hydrolase
AYX22_05810	COG0483	inositol monophosphate 1-phosphatase activity
AYX22_05835	COG0045	succinate-CoA ligase (ADP-forming) activity
AYX22_05850	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AYX22_05890	COG1396	sequence-specific DNA binding
AYX22_05910	COG0028	Belongs to the TPP enzyme family
AYX22_05960	COG1401	restriction endodeoxyribonuclease activity
AYX22_05980	COG0745	RESPONSE REGULATOR receiver
AYX22_05995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AYX22_06010	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_06040	COG1902	pentaerythritol trinitrate reductase activity
AYX22_06055	COG2376	Dihydroxyacetone kinase
AYX22_06060	COG0698	ribose 5-phosphate isomerase
AYX22_06065	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYX22_06070	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_06075	COG2271	Major facilitator Superfamily
AYX22_06080	COG0149	triose-phosphate isomerase activity
AYX22_06130	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AYX22_06135	COG3103	Sh3 type 3 domain protein
AYX22_06135	COG0366	Alpha amylase catalytic
AYX22_06140	COG1254	Belongs to the acylphosphatase family
AYX22_06145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AYX22_06150	COG2186	Transcriptional regulator
AYX22_06155	COG0477	Major facilitator Superfamily
AYX22_06165	COG0640	Transcriptional regulator
AYX22_06175	COG4209	transmembrane transport
AYX22_06180	COG0395	ABC-type sugar transport system, permease component
AYX22_06195	COG0402	S-adenosylhomocysteine deaminase activity
AYX22_06225	COG4221	oxidoreductase activity
AYX22_06235	COG1472	Belongs to the glycosyl hydrolase 3 family
AYX22_06240	COG0673	inositol 2-dehydrogenase activity
AYX22_06255	COG1609	Transcriptional regulator
AYX22_06275	COG2365	Tyrosine phosphatase family
AYX22_06280	COG3639	organic phosphonate transmembrane transporter activity
AYX22_06285	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AYX22_06295	COG0477	Major facilitator Superfamily
AYX22_06315	COG0604	alcohol dehydrogenase
AYX22_06315	COG3321	synthase
AYX22_06325	COG1309	transcriptional regulator
AYX22_06380	COG1846	Transcriptional regulator
AYX22_06385	COG0697	spore germination
AYX22_06420	COG0531	amino acid
AYX22_06435	COG1278	Cold shock
AYX22_06450	COG0477	Major facilitator Superfamily
AYX22_06455	COG0501	Belongs to the peptidase M48B family
AYX22_06470	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AYX22_06475	COG0438	transferase activity, transferring glycosyl groups
AYX22_06485	COG0789	Transcriptional regulator
AYX22_06490	COG0071	Belongs to the small heat shock protein (HSP20) family
AYX22_06525	COG2814	Major facilitator Superfamily
AYX22_06530	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AYX22_06545	COG0138	bifunctional purine biosynthesis protein purh
AYX22_06560	COG2838	Isocitrate dehydrogenase
AYX22_06570	COG3639	organic phosphonate transmembrane transporter activity
AYX22_06575	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AYX22_06590	COG2188	Transcriptional regulator
AYX22_06595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYX22_06615	COG1136	(ABC) transporter
AYX22_06625	COG4213	ABC transporter substrate-binding protein
AYX22_06630	COG1172	Belongs to the binding-protein-dependent transport system permease family
AYX22_06635	COG1129	ABC transporter
AYX22_06655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AYX22_06660	COG0531	amino acid
AYX22_06700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AYX22_06705	COG1131	(ABC) transporter
AYX22_06730	COG0180	Tryptophanyl-tRNA synthetase
AYX22_06765	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AYX22_06780	COG2009	succinate dehydrogenase
AYX22_06790	COG1473	amidohydrolase
AYX22_06790	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AYX22_06795	COG1846	Transcriptional regulator
AYX22_06800	COG1764	response to oxidative stress
AYX22_06805	COG2130	NADP-dependent
AYX22_06810	COG1744	ABC transporter substrate-binding protein PnrA-like
AYX22_06815	COG3845	ABC transporter
AYX22_06820	COG4603	Belongs to the binding-protein-dependent transport system permease family
AYX22_06825	COG1079	Belongs to the binding-protein-dependent transport system permease family
AYX22_06840	COG0586	Pfam SNARE associated Golgi protein
AYX22_06845	COG0586	Pfam SNARE associated Golgi protein
AYX22_06850	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AYX22_06860	COG0148	phosphopyruvate hydratase activity
AYX22_06885	COG1252	NADH dehydrogenase
AYX22_06925	COG0559	Belongs to the binding-protein-dependent transport system permease family
AYX22_06935	COG0183	Belongs to the thiolase family
AYX22_06940	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AYX22_06950	COG2017	converts alpha-aldose to the beta-anomer
AYX22_06960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AYX22_06970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AYX22_06980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AYX22_06990	COG1331	Highly conserved protein containing a thioredoxin domain
AYX22_07000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AYX22_07005	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AYX22_07045	COG0114	fumarate hydratase activity
AYX22_07050	COG0288	reversible hydration of carbon dioxide
AYX22_07060	COG1494	fructose-1,6-bisphosphatase
AYX22_07070	COG1482	cell wall glycoprotein biosynthetic process
AYX22_07130	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AYX22_07135	COG1376	ErfK ybiS ycfS ynhG family protein
AYX22_07140	COG1357	PFAM Pentapeptide repeats (8 copies)
AYX22_07195	COG0714	Associated with various cellular activities
AYX22_07200	COG0084	hydrolase, TatD family'
AYX22_07205	COG3583	domain protein
AYX22_07210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AYX22_07215	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AYX22_07220	COG0488	(ABC) transporter
AYX22_07230	COG1309	transcriptional regulator
AYX22_07240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AYX22_07245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AYX22_07250	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AYX22_07255	COG0193	aminoacyl-tRNA hydrolase activity
AYX22_07280	COG0822	iron-sulfur transferase activity
AYX22_07285	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AYX22_07300	COG0702	epimerase
AYX22_07310	COG1988	membrane-bound metal-dependent
AYX22_07320	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AYX22_07390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AYX22_07395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AYX22_07405	COG0492	ferredoxin-NADP+ reductase activity
AYX22_07410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AYX22_07430	COG0456	acetyltransferase
AYX22_07435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AYX22_07450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYX22_07450	COG2146	nitrite reductase [NAD(P)H] activity
AYX22_07460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYX22_07465	COG1621	beta-fructofuranosidase activity
AYX22_07495	COG0243	molybdopterin cofactor binding
AYX22_07500	COG2223	nitrite transmembrane transporter activity
AYX22_07505	COG0477	Major facilitator Superfamily
AYX22_07515	COG4770	biotin carboxylase activity
AYX22_07520	COG0424	maF-like protein
AYX22_07525	COG2409	Drug exporters of the RND superfamily
AYX22_07530	COG1309	transcriptional regulator
AYX22_07540	COG1823	symporter activity
AYX22_07565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AYX22_07570	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_07575	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AYX22_07575	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AYX22_07600	COG0714	Associated with various cellular activities
AYX22_07620	COG0631	protein serine/threonine phosphatase activity
AYX22_07640	COG1674	ftsk spoiiie
AYX22_07650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AYX22_07655	COG0483	inositol monophosphate 1-phosphatase activity
AYX22_07665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYX22_07675	COG0251	oxidation-reduction process
AYX22_07680	COG4565	transcriptional regulatory protein
AYX22_07690	COG2851	Citrate transporter
AYX22_07695	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AYX22_07700	COG0154	amidase activity
AYX22_07705	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AYX22_07715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AYX22_07720	COG4209	transmembrane transport
AYX22_07725	COG0395	ABC-type sugar transport system, permease component
AYX22_07750	COG1063	alcohol dehydrogenase
AYX22_07755	COG0156	8-amino-7-oxononanoate synthase activity
AYX22_07770	COG1228	amidohydrolase
AYX22_07775	COG1470	cell adhesion involved in biofilm formation
AYX22_07775	COG0366	Alpha amylase catalytic
AYX22_07780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AYX22_07785	COG1940	carbohydrate kinase activity
AYX22_07795	COG0191	fructose-bisphosphate aldolase activity
AYX22_07820	COG2873	o-acetylhomoserine
AYX22_07825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYX22_07860	COG0423	glycine-tRNA ligase activity
AYX22_07885	COG0358	DNA primase activity
AYX22_07905	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AYX22_07910	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AYX22_07920	COG2814	Major facilitator Superfamily
AYX22_07930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AYX22_07960	COG0052	Belongs to the universal ribosomal protein uS2 family
AYX22_07965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AYX22_07970	COG0528	UMP kinase activity
AYX22_07975	COG0233	cytoplasmic translational termination
AYX22_07980	COG0575	Belongs to the CDS family
AYX22_07995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AYX22_08010	COG3275	phosphorelay sensor kinase activity
AYX22_08020	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AYX22_08025	COG1796	DNA polymerase
AYX22_08025	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AYX22_08045	COG1522	sequence-specific DNA binding
AYX22_08055	COG0022	dehydrogenase e1 component
AYX22_08060	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYX22_08065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AYX22_08080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AYX22_08090	COG1960	acyl-CoA dehydrogenase activity
AYX22_08115	COG0673	inositol 2-dehydrogenase activity
AYX22_08125	COG0673	inositol 2-dehydrogenase activity
AYX22_08135	COG1175	transmembrane transport
AYX22_08140	COG1653	transport
AYX22_08145	COG1609	Transcriptional regulator
AYX22_08155	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AYX22_08160	COG0750	zinc metalloprotease
AYX22_08170	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AYX22_08185	COG0442	prolyl-tRNA aminoacylation
AYX22_08195	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AYX22_08200	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
AYX22_08215	COG0779	Required for maturation of 30S ribosomal subunits
AYX22_08230	COG0481	GTPase activity
AYX22_08230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AYX22_08235	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AYX22_08240	COG0590	tRNA wobble adenosine to inosine editing
AYX22_08245	COG0436	Aminotransferase
AYX22_08250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AYX22_08270	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AYX22_08275	COG1185	polyribonucleotide nucleotidyltransferase activity
AYX22_08280	COG0612	Peptidase, M16
AYX22_08300	COG0745	RESPONSE REGULATOR receiver
AYX22_08305	COG2205	protein histidine kinase activity
AYX22_08325	COG0521	Mo-molybdopterin cofactor biosynthetic process
AYX22_08335	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AYX22_08360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYX22_08365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AYX22_08370	COG1674	ftsk spoiiie
AYX22_08380	COG1546	Belongs to the CinA family
AYX22_08380	COG1058	Belongs to the CinA family
AYX22_08385	COG1396	sequence-specific DNA binding
AYX22_08400	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AYX22_08405	COG2137	regulation of response to DNA damage stimulus
AYX22_08410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AYX22_08415	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AYX22_08420	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AYX22_08425	COG2813	Specifically methylates the guanine in position
AYX22_08430	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AYX22_08440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AYX22_08445	COG1388	LysM domain
AYX22_08450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AYX22_08455	COG0131	Imidazoleglycerol-phosphate dehydratase
AYX22_08460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AYX22_08465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AYX22_08480	COG2826	transposase and inactivated derivatives, IS30 family
AYX22_08490	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AYX22_08495	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AYX22_08500	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AYX22_08505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYX22_08510	COG2814	Major facilitator Superfamily
AYX22_08525	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AYX22_08545	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AYX22_08550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYX22_08550	COG0072	phenylalanine-tRNA ligase activity
AYX22_08555	COG3591	Belongs to the peptidase S1B family
AYX22_08610	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AYX22_08615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AYX22_08620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AYX22_08625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AYX22_08630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AYX22_08635	COG1438	arginine binding
AYX22_08640	COG0137	argininosuccinate synthase activity
AYX22_08645	COG0165	Argininosuccinate lyase
AYX22_08660	COG2094	Belongs to the DNA glycosylase MPG family
AYX22_08670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AYX22_08700	COG0647	UMP catabolic process
AYX22_08715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AYX22_08720	COG0497	DNA recombination
AYX22_08725	COG0504	CTP synthase activity
AYX22_08745	COG0494	nUDIX hydrolase
AYX22_08755	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AYX22_08760	COG2079	MmgE PrpD family protein
AYX22_08775	COG3290	protein histidine kinase activity
AYX22_08780	COG1301	dicarboxylic acid transport
AYX22_08790	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AYX22_08795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AYX22_08810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AYX22_08820	COG1160	GTP binding
AYX22_08830	COG1846	Transcriptional regulator
AYX22_08835	COG2814	Major facilitator Superfamily
AYX22_08845	COG0509	glycine decarboxylation via glycine cleavage system
AYX22_08850	COG1716	ATPase activity
AYX22_08875	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AYX22_08885	COG1940	carbohydrate kinase activity
AYX22_08910	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AYX22_08915	COG2815	serine threonine protein kinase
AYX22_08915	COG0515	serine threonine protein kinase
AYX22_08930	COG0142	geranyltranstransferase activity
AYX22_08940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AYX22_08950	COG2001	Belongs to the MraZ family
AYX22_08955	COG0275	rRNA processing
AYX22_08965	COG0768	penicillin binding
AYX22_08970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AYX22_08975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AYX22_08980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AYX22_08985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AYX22_08995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AYX22_09000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AYX22_09010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AYX22_09015	COG1496	oxidoreductase activity
AYX22_09020	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AYX22_09025	COG1799	cell septum assembly
AYX22_09040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AYX22_09065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AYX22_09070	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AYX22_09075	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_09090	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AYX22_09095	COG0174	glutamine synthetase
AYX22_09100	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AYX22_09150	COG1045	serine acetyltransferase
AYX22_09155	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AYX22_09160	COG0321	lipoyl(octanoyl) transferase activity
AYX22_09165	COG0515	serine threonine protein kinase
AYX22_09170	COG1090	epimerase
AYX22_09175	COG4946	Tricorn protease homolog
AYX22_09175	COG0793	Belongs to the peptidase S41A family
AYX22_09180	COG1764	response to oxidative stress
AYX22_09190	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYX22_09195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYX22_09200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AYX22_09220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AYX22_09250	COG1271	oxidase subunit
AYX22_09255	COG1294	oxidase, subunit
AYX22_09260	COG4988	ABC transporter
AYX22_09280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AYX22_09285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AYX22_09285	COG0045	succinate-CoA ligase (ADP-forming) activity
AYX22_09285	COG1042	CoA-binding domain protein
AYX22_09300	COG1435	thymidine kinase activity
AYX22_09320	COG0756	dUTP diphosphatase activity
AYX22_09345	COG0569	domain protein
AYX22_09350	COG0531	amino acid
AYX22_09355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AYX22_09360	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AYX22_09365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AYX22_09385	COG0667	Aldo Keto reductase
AYX22_09390	COG1024	Enoyl-CoA hydratase
AYX22_09390	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYX22_09395	COG0183	Belongs to the thiolase family
AYX22_09425	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AYX22_09440	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AYX22_09460	COG3135	benzoate transporter
AYX22_09470	COG0531	amino acid
AYX22_09515	COG0242	peptide deformylase activity
AYX22_09520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AYX22_09530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AYX22_09560	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AYX22_09565	COG0140	phosphoribosyl-ATP diphosphatase activity
AYX22_09570	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AYX22_09575	COG0107	imidazoleglycerol-phosphate synthase activity
AYX22_09585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AYX22_09605	COG0134	indole-3-glycerol-phosphate synthase activity
AYX22_09610	COG0133	tryptophan synthase activity
AYX22_09615	COG0159	tryptophan synthase activity
AYX22_09620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AYX22_09625	COG0067	glutamate synthase
AYX22_09625	COG0069	glutamate synthase activity
AYX22_09625	COG0070	glutamate synthase
AYX22_09640	COG2826	transposase and inactivated derivatives, IS30 family
AYX22_09655	COG1609	Transcriptional regulator
AYX22_09660	COG1653	transport
AYX22_09665	COG1175	transmembrane transport
AYX22_09670	COG0395	ABC-type sugar transport system, permease component
AYX22_09675	COG3250	beta-galactosidase activity
AYX22_09680	COG1414	Transcriptional regulator
AYX22_09690	COG2124	cytochrome p450
AYX22_09700	COG2814	Major facilitator Superfamily
AYX22_09710	COG3250	beta-galactosidase activity
AYX22_09730	COG3237	CsbD-like
AYX22_09745	COG3842	ATPase activity
AYX22_09750	COG0318	PFAM AMP-dependent synthetase and ligase
AYX22_09775	COG2211	Major facilitator Superfamily
AYX22_09780	COG3250	beta-galactosidase activity
AYX22_09785	COG2723	6-phospho-beta-galactosidase activity
AYX22_09790	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_09795	COG0028	Belongs to the TPP enzyme family
AYX22_09800	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AYX22_09815	COG1131	(ABC) transporter
AYX22_09850	COG1131	(ABC) transporter
AYX22_09870	COG0574	Belongs to the PEP-utilizing enzyme family
AYX22_09870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AYX22_09920	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AYX22_09965	COG0857	belongs to the CobB CobQ family
AYX22_09965	COG0280	phosphate acetyltransferase
AYX22_09975	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AYX22_09995	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AYX22_10005	COG2132	Multicopper oxidase
AYX22_10010	COG3118	belongs to the thioredoxin family
AYX22_10055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AYX22_10060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYX22_10065	COG1126	abc transporter atp-binding protein
AYX22_10085	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_10105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYX22_10150	COG0656	L-ascorbic acid biosynthetic process
AYX22_10175	COG1063	alcohol dehydrogenase
AYX22_10190	COG1940	carbohydrate kinase activity
AYX22_10195	COG0673	inositol 2-dehydrogenase activity
AYX22_10200	COG0673	inositol 2-dehydrogenase activity
AYX22_10205	COG1172	Belongs to the binding-protein-dependent transport system permease family
AYX22_10210	COG1879	ABC-type sugar transport system periplasmic component
AYX22_10215	COG1082	Xylose isomerase domain protein TIM barrel
AYX22_10220	COG1082	Xylose isomerase domain protein TIM barrel
AYX22_10225	COG1129	ABC transporter
AYX22_10235	COG3559	Exporter of polyketide antibiotics
AYX22_10240	COG1131	(ABC) transporter
AYX22_10255	COG0436	Aminotransferase
AYX22_10295	COG1012	belongs to the aldehyde dehydrogenase family
AYX22_10300	COG0460	homoserine dehydrogenase
AYX22_10305	COG0464	growth
AYX22_10310	COG2354	Protein conserved in bacteria
AYX22_10320	COG0747	negative chemotaxis
AYX22_10325	COG0601	transmembrane transport
AYX22_10330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AYX22_10335	COG0444	Belongs to the ABC transporter superfamily
AYX22_10340	COG4608	Belongs to the ABC transporter superfamily
AYX22_10350	COG1621	beta-fructofuranosidase activity
AYX22_10365	COG2828	Protein conserved in bacteria
AYX22_10385	COG0747	negative chemotaxis
AYX22_10395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AYX22_10400	COG4172	Belongs to the ABC transporter superfamily
AYX22_10410	COG0531	amino acid
AYX22_10415	COG2318	DinB family
AYX22_10430	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_10445	COG0028	Belongs to the TPP enzyme family
AYX22_10460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AYX22_10465	COG1120	ATPase activity
AYX22_10470	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AYX22_10505	COG0179	Fumarylacetoacetate (FAA) hydrolase
AYX22_10515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYX22_10525	COG0179	Fumarylacetoacetate (FAA) hydrolase
AYX22_10540	COG0583	DNA-binding transcription factor activity
AYX22_10545	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_10550	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AYX22_10565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AYX22_10580	COG0110	maltose O-acetyltransferase activity
AYX22_10595	COG1064	alcohol dehydrogenase
AYX22_10600	COG1643	Atp-dependent helicase
AYX22_10605	COG1228	amidohydrolase
AYX22_10640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYX22_10645	COG0009	L-threonylcarbamoyladenylate synthase
AYX22_10655	COG1131	(ABC) transporter
AYX22_10670	COG2188	Transcriptional regulator
AYX22_10685	COG1053	succinate dehydrogenase
AYX22_10705	COG3483	tryptophan 2,3-dioxygenase activity
AYX22_10740	COG2050	protein possibly involved in aromatic compounds catabolism
AYX22_10750	COG4552	Acetyltransferase involved in intracellular survival and related
AYX22_10760	COG0539	negative regulation of cytoplasmic translation
AYX22_10765	COG1739	Uncharacterized protein family UPF0029
AYX22_10770	COG0237	dephospho-CoA kinase activity
AYX22_10770	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AYX22_10775	COG0556	nucleotide-excision repair
AYX22_10800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AYX22_10810	COG4106	trans-aconitate 2-methyltransferase activity
AYX22_10825	COG0546	phosphoglycolate phosphatase activity
AYX22_10835	COG0322	excinuclease ABC activity
AYX22_10840	COG1660	Displays ATPase and GTPase activities
AYX22_10850	COG1481	regulation of sporulation
AYX22_10855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AYX22_10860	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AYX22_10865	COG0126	phosphoglycerate kinase activity
AYX22_10870	COG0149	triose-phosphate isomerase activity
AYX22_10875	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AYX22_10880	COG0363	glucosamine-6-phosphate deaminase activity
AYX22_10895	COG0166	Belongs to the GPI family
AYX22_10900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AYX22_10910	COG0109	protoheme IX farnesyltransferase activity
AYX22_10935	COG0577	efflux transmembrane transporter activity
AYX22_10935	COG1136	(ABC) transporter
AYX22_10940	COG1612	heme a metabolic process
AYX22_10945	COG0842	Transport permease protein
AYX22_10950	COG1131	(ABC) transporter
AYX22_10965	COG0719	Fe-S assembly protein
AYX22_10975	COG0396	ATPase activity
AYX22_10980	COG2151	metal-sulfur cluster biosynthetic enzyme
AYX22_10990	COG0318	PFAM AMP-dependent synthetase and ligase
AYX22_11005	COG1122	ATPase activity
AYX22_11010	COG1268	BioY protein
AYX22_11015	COG0488	(ABC) transporter
AYX22_11040	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_11045	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_11050	COG1129	ABC transporter
AYX22_11060	COG3830	Belongs to the UPF0237 family
AYX22_11060	COG0560	Phosphoserine phosphatase
AYX22_11065	COG1119	ATPase activity
AYX22_11080	COG0254	rRNA binding
AYX22_11095	COG2855	membrane
AYX22_11120	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AYX22_11125	COG0297	glycogen (starch) synthase activity
AYX22_11140	COG0183	Belongs to the thiolase family
AYX22_11145	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_11160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AYX22_11175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AYX22_11180	COG0673	inositol 2-dehydrogenase activity
AYX22_11185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AYX22_11190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AYX22_11200	COG1215	transferase activity, transferring glycosyl groups
AYX22_11205	COG2244	polysaccharide biosynthetic process
AYX22_11255	COG1088	dTDP-glucose 4,6-dehydratase activity
AYX22_11260	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AYX22_11265	COG0667	Aldo Keto reductase
AYX22_11270	COG1968	undecaprenyl-diphosphatase activity
AYX22_11275	COG0215	cysteine-tRNA ligase activity
AYX22_11285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYX22_11290	COG1994	Peptidase M50
AYX22_11290	COG0517	IMP dehydrogenase activity
AYX22_11300	COG1222	aaa ATPase
AYX22_11305	COG4122	O-methyltransferase activity
AYX22_11315	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AYX22_11320	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AYX22_11325	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AYX22_11330	COG0545	Peptidyl-prolyl cis-trans isomerase
AYX22_11350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AYX22_11355	COG0805	protein transport
AYX22_11360	COG4581	dead DEAH box helicase
AYX22_11365	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AYX22_11370	COG1216	Glycosyl transferase, family 2
AYX22_11395	COG0823	Involved in the tonB-independent uptake of proteins
AYX22_11395	COG1506	peptidase
AYX22_11395	COG4946	Tricorn protease homolog
AYX22_11400	COG0242	peptide deformylase activity
AYX22_11420	COG3424	synthase
AYX22_11425	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AYX22_11430	COG2188	Transcriptional regulator
AYX22_11435	COG3718	enzyme involved in inositol metabolism
AYX22_11440	COG0673	inositol 2-dehydrogenase activity
AYX22_11465	COG0673	inositol 2-dehydrogenase activity
AYX22_11475	COG1172	Belongs to the binding-protein-dependent transport system permease family
AYX22_11505	COG2814	Major facilitator Superfamily
AYX22_11510	COG1082	Xylose isomerase domain protein TIM barrel
AYX22_11515	COG0673	inositol 2-dehydrogenase activity
AYX22_11530	COG3962	Belongs to the TPP enzyme family
AYX22_11540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AYX22_11545	COG1942	4-Oxalocrotonate Tautomerase
AYX22_11570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AYX22_11575	COG1845	cytochrome c oxidase, subunit III
AYX22_11580	COG2010	Cytochrome c
AYX22_11585	COG0723	plastoquinol--plastocyanin reductase activity
AYX22_11590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AYX22_11595	COG2188	Transcriptional regulator
AYX22_11600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYX22_11610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AYX22_11615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AYX22_11635	COG0167	dihydroorotate dehydrogenase activity
AYX22_11650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AYX22_11655	COG1381	Involved in DNA repair and RecF pathway recombination
AYX22_11660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AYX22_11665	COG3590	peptidase
AYX22_11670	COG1316	TRANSCRIPTIONal
AYX22_11675	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AYX22_11685	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AYX22_11700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AYX22_11705	COG0484	heat shock protein binding
AYX22_11710	COG1420	regulation of RNA biosynthetic process
AYX22_11730	COG0481	GTPase activity
AYX22_11740	COG0268	Binds directly to 16S ribosomal RNA
AYX22_11760	COG1307	EDD domain protein, DegV family
AYX22_11765	COG0495	leucyl-tRNA aminoacylation
AYX22_11770	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AYX22_11775	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AYX22_11780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AYX22_11785	COG2390	Transcriptional regulator
AYX22_11790	COG0656	L-ascorbic acid biosynthetic process
AYX22_11800	COG0438	transferase activity, transferring glycosyl groups
AYX22_11810	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AYX22_11820	COG1758	RNA polymerase activity
AYX22_11825	COG0194	GDP metabolic process
AYX22_11835	COG0284	orotidine-5'-phosphate decarboxylase activity
AYX22_11840	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AYX22_11845	COG0505	Belongs to the CarA family
AYX22_11855	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AYX22_11860	COG0540	Belongs to the ATCase OTCase family
AYX22_11865	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AYX22_11875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AYX22_11880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AYX22_11890	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AYX22_11895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AYX22_11900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AYX22_11905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AYX22_11920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AYX22_11935	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AYX22_11955	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AYX22_11960	COG0124	histidyl-tRNA synthetase
AYX22_11970	COG1196	nuclear chromosome segregation
AYX22_11980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AYX22_11985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AYX22_11990	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AYX22_12000	COG2255	four-way junction helicase activity
AYX22_12005	COG0632	four-way junction helicase activity
AYX22_12010	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AYX22_12015	COG0217	transcriptional regulatory protein
AYX22_12020	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AYX22_12040	COG0339	signal peptide processing
AYX22_12045	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AYX22_12050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AYX22_12060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AYX22_12065	COG0587	DNA-directed DNA polymerase activity
AYX22_12090	COG2135	peptidase activity
AYX22_12105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYX22_12140	COG4804	nuclease activity
AYX22_12145	COG0412	Dienelactone hydrolase
AYX22_12155	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AYX22_12160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AYX22_12165	COG1780	Probably involved in ribonucleotide reductase function
AYX22_12175	COG0583	DNA-binding transcription factor activity
AYX22_12185	COG2826	transposase and inactivated derivatives, IS30 family
AYX22_12215	COG0714	Associated with various cellular activities
AYX22_12235	COG1653	transport
AYX22_12245	COG2813	Specifically methylates the guanine in position
AYX22_12270	COG0799	negative regulation of ribosome biogenesis
AYX22_12280	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AYX22_12290	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AYX22_12295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AYX22_12300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AYX22_12305	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AYX22_12310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AYX22_12315	COG0352	thiamine-phosphate diphosphorylase activity
AYX22_12315	COG0351	phosphomethylpyrimidine kinase
AYX22_12315	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AYX22_12320	COG1530	ribonuclease E activity
AYX22_12330	COG0105	UTP biosynthetic process
AYX22_12340	COG0285	dihydrofolate synthase activity
AYX22_12345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AYX22_12360	COG0525	valine-tRNA ligase activity
AYX22_12365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AYX22_12370	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AYX22_12375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AYX22_12380	COG0740	serine-type endopeptidase activity
AYX22_12385	COG0740	serine-type endopeptidase activity
AYX22_12390	COG0544	peptidyl-prolyl cis-trans isomerase activity
AYX22_12435	COG0668	transmembrane transport
AYX22_12450	COG1946	Acyl-CoA thioesterase
AYX22_12475	COG0629	single-stranded DNA binding
AYX22_12510	COG0242	peptide deformylase activity
AYX22_12540	COG3022	response to hydroperoxide
AYX22_12550	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AYX22_12555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AYX22_12565	COG1045	serine acetyltransferase
AYX22_12570	COG0300	oxidoreductase activity
AYX22_12575	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AYX22_12585	COG1063	alcohol dehydrogenase
AYX22_12590	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_12600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AYX22_12610	COG0477	Major facilitator Superfamily
AYX22_12645	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AYX22_12660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AYX22_12665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AYX22_12680	COG4974	Belongs to the 'phage' integrase family
AYX22_12715	COG0792	nuclease activity
AYX22_12725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AYX22_12730	COG0681	Belongs to the peptidase S26 family
AYX22_12735	COG0681	Belongs to the peptidase S26 family
AYX22_12740	COG0335	large ribosomal subunit rRNA binding
AYX22_12745	COG0336	Belongs to the RNA methyltransferase TrmD family
AYX22_12750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AYX22_12755	COG1837	Belongs to the UPF0109 family
AYX22_12760	COG0228	four-way junction DNA binding
AYX22_12770	COG2514	catechol 2,3-dioxygenase activity
AYX22_12780	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AYX22_12795	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AYX22_12810	COG2814	Major facilitator Superfamily
AYX22_12835	COG1137	ATPase activity
AYX22_12870	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AYX22_12875	COG0571	ribonuclease III activity
AYX22_12880	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AYX22_12895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AYX22_12910	COG0742	ribosomal rna small subunit methyltransferase
AYX22_12935	COG1181	Belongs to the D-alanine--D-alanine ligase family
AYX22_12940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AYX22_12950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AYX22_12955	COG0066	3-isopropylmalate dehydratase activity
AYX22_12960	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AYX22_12965	COG1414	Transcriptional regulator
AYX22_13000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AYX22_13005	COG0179	Fumarylacetoacetate (FAA) hydrolase
AYX22_13010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYX22_13015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AYX22_13020	COG0473	3-isopropylmalate dehydrogenase activity
AYX22_13025	COG4585	Histidine kinase
AYX22_13030	COG2197	response regulator
AYX22_13035	COG1136	(ABC) transporter
AYX22_13035	COG0577	efflux transmembrane transporter activity
AYX22_13050	COG1136	(ABC) transporter
AYX22_13050	COG0577	efflux transmembrane transporter activity
AYX22_13060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AYX22_13065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AYX22_13070	COG0440	acetolactate synthase activity
AYX22_13080	COG0129	dihydroxy-acid dehydratase activity
AYX22_13090	COG0088	Forms part of the polypeptide exit tunnel
AYX22_13095	COG2133	pyrroloquinoline quinone binding
AYX22_13130	COG0579	oxidoreductase
AYX22_13135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AYX22_13140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYX22_13150	COG1305	Transglutaminase-like
AYX22_13175	COG0179	Fumarylacetoacetate (FAA) hydrolase
AYX22_13185	COG1104	cysteine desulfurase activity
AYX22_13195	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AYX22_13200	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AYX22_13210	COG1522	sequence-specific DNA binding
AYX22_13215	COG1113	amino acid transport
AYX22_13225	COG0022	dehydrogenase e1 component
AYX22_13230	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYX22_13250	COG0477	Major facilitator Superfamily
AYX22_13255	COG1414	Transcriptional regulator
AYX22_13280	COG1116	anion transmembrane transporter activity
AYX22_13285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYX22_13300	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AYX22_13315	COG0419	ATPase involved in DNA repair
AYX22_13320	COG0420	3'-5' exonuclease activity
AYX22_13335	COG2149	membrane
AYX22_13360	COG1131	(ABC) transporter
AYX22_13375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AYX22_13380	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AYX22_13390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AYX22_13400	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AYX22_13410	COG1335	isochorismatase
AYX22_13425	COG0363	glucosamine-6-phosphate deaminase activity
AYX22_13440	COG1902	pentaerythritol trinitrate reductase activity
AYX22_13470	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AYX22_13475	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AYX22_13485	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AYX22_13490	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AYX22_13500	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AYX22_13505	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AYX22_13510	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AYX22_13515	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AYX22_13520	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AYX22_13525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AYX22_13530	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AYX22_13535	COG0356	it plays a direct role in the translocation of protons across the membrane
AYX22_13555	COG1216	Glycosyl transferase, family 2
AYX22_13570	COG2890	protein-(glutamine-N5) methyltransferase activity
AYX22_13575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AYX22_13585	COG0083	homoserine kinase activity
AYX22_13590	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AYX22_13595	COG0460	homoserine dehydrogenase
AYX22_13600	COG0019	diaminopimelate decarboxylase activity
AYX22_13605	COG0018	arginyl-trna synthetase
AYX22_13620	COG0543	2 iron, 2 sulfur cluster binding
AYX22_13620	COG0633	Ferredoxin
AYX22_13650	COG1643	Atp-dependent helicase
AYX22_13655	COG0537	adenosine 5'-monophosphoramidase activity
AYX22_13660	COG1064	alcohol dehydrogenase
AYX22_13685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AYX22_13690	COG1121	(ABC) transporter
AYX22_13705	COG1253	flavin adenine dinucleotide binding
AYX22_13710	COG0567	Dehydrogenase, E1 component
AYX22_13710	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYX22_13735	COG1595	DNA-templated transcription, initiation
AYX22_13745	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AYX22_13755	COG0483	inositol monophosphate 1-phosphatase activity
AYX22_13760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AYX22_13795	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AYX22_13805	COG2177	Part of the ABC transporter FtsEX involved in
AYX22_13810	COG2884	Cell division ATP-binding protein ftsE
AYX22_13815	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AYX22_13915	COG1475	DNA binding
AYX22_14015	COG0740	serine-type endopeptidase activity
AYX22_14120	COG0739	heme binding
AYX22_14230	COG1216	Glycosyl transferase, family 2
AYX22_14245	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AYX22_14275	COG2902	Dehydrogenase
AYX22_14310	COG0653	protein targeting
AYX22_14315	COG3214	Protein conserved in bacteria
AYX22_14320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AYX22_14325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AYX22_14330	COG5401	PFAM Sporulation and spore germination
AYX22_14335	COG5002	protein histidine kinase activity
AYX22_14360	COG0714	Associated with various cellular activities
AYX22_14395	COG0601	transmembrane transport
AYX22_14415	COG0482	sulfurtransferase activity
AYX22_14435	COG0484	heat shock protein binding
AYX22_14440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AYX22_14465	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AYX22_14470	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AYX22_14480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AYX22_14490	COG1842	Phage shock protein A
AYX22_14495	COG2188	Transcriptional regulator
AYX22_14510	COG1615	UPF0182 protein
AYX22_14515	COG3480	Lon protease (S16) C-terminal proteolytic domain
AYX22_14535	COG2816	NAD+ diphosphatase activity
AYX22_14565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYX22_14570	COG0765	amino acid transport
AYX22_14575	COG1126	abc transporter atp-binding protein
AYX22_14580	COG1472	Belongs to the glycosyl hydrolase 3 family
AYX22_14585	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AYX22_14595	COG0113	porphobilinogen synthase activity
AYX22_14605	COG0181	hydroxymethylbilane synthase activity
AYX22_14610	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AYX22_14615	COG3253	May function as heme-dependent peroxidase
AYX22_14620	COG1231	oxidoreductase activity
AYX22_14625	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AYX22_14630	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AYX22_14640	COG1309	transcriptional regulator
AYX22_14655	COG2154	pterin-4-alpha-carbinolamine dehydratase
AYX22_14660	COG2022	thiamine diphosphate biosynthetic process
AYX22_14670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYX22_14670	COG2022	thiamine diphosphate biosynthetic process
AYX22_14675	COG0352	thiamine-phosphate diphosphorylase activity
AYX22_14685	COG2314	TM2 domain
AYX22_14695	COG0513	Belongs to the DEAD box helicase family
AYX22_14705	COG2095	MarC family integral membrane protein
AYX22_14715	COG0006	proline dipeptidase activity
AYX22_14725	COG2239	Acts as a magnesium transporter
AYX22_14740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AYX22_14750	COG1595	DNA-templated transcription, initiation
AYX22_14775	COG1126	abc transporter atp-binding protein
AYX22_14780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYX22_14785	COG0765	amino acid transport
AYX22_14790	COG0765	amino acid transport
AYX22_14795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AYX22_14800	COG2171	N-acyltransferase activity
AYX22_14815	COG3226	Transcriptional regulator
AYX22_14820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AYX22_14845	COG1217	gtp-binding protein TYPA
AYX22_14860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AYX22_14865	COG0601	transmembrane transport
AYX22_14890	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_14925	COG5290	Psort location Cytoplasmic, score
AYX22_15065	COG0012	GTP binding
AYX22_15075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AYX22_15085	COG1570	exodeoxyribonuclease VII activity
AYX22_15090	COG1722	exodeoxyribonuclease VII activity
AYX22_15095	COG2326	polyphosphate kinase activity
AYX22_15100	COG0436	Aminotransferase
AYX22_15125	COG1162	GTPase activity
AYX22_15145	COG2971	BadF BadG BcrA BcrD
AYX22_15150	COG2070	2-Nitropropane dioxygenase
AYX22_15155	COG0583	DNA-binding transcription factor activity
AYX22_15160	COG2814	Major facilitator Superfamily
AYX22_15165	COG3548	integral membrane protein
AYX22_15190	COG0598	Magnesium transport protein CorA
AYX22_15200	COG1528	Iron-storage protein
AYX22_15205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AYX22_15210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AYX22_15220	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AYX22_15250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AYX22_15255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AYX22_15275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AYX22_15275	COG0519	Catalyzes the synthesis of GMP from XMP
AYX22_15295	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AYX22_15300	COG0516	GMP reductase activity
AYX22_15335	COG2072	flavoprotein involved in K transport
AYX22_15345	COG2197	response regulator
AYX22_15350	COG0459	protein refolding
AYX22_15355	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AYX22_15370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AYX22_15375	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AYX22_15385	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AYX22_15390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AYX22_15395	COG0456	acetyltransferase
AYX22_15405	COG0802	atpase or kinase
AYX22_15410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AYX22_15420	COG1486	melibiose metabolic process
AYX22_15430	COG0438	transferase activity, transferring glycosyl groups
AYX22_15435	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AYX22_15445	COG0667	Aldo Keto reductase
AYX22_15470	COG0736	holo-[acyl-carrier-protein] synthase activity
AYX22_15475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AYX22_15480	COG1072	(Pantothenic acid kinase))
AYX22_15490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYX22_15495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AYX22_15500	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AYX22_15530	COG0455	bacterial-type flagellum organization
AYX22_15550	COG0101	tRNA pseudouridine synthase activity
AYX22_15555	COG0203	ribosomal protein L17
AYX22_15560	COG0202	RNA polymerase activity
AYX22_15565	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AYX22_15570	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AYX22_15575	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AYX22_15580	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AYX22_15585	COG3191	aminopeptidase activity
AYX22_15620	COG2124	cytochrome p450
AYX22_15625	COG1215	transferase activity, transferring glycosyl groups
AYX22_15630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AYX22_15635	COG0563	adenylate kinase activity
AYX22_15645	COG0200	Binds to the 23S rRNA
AYX22_15650	COG1841	ribosomal large subunit assembly
AYX22_15655	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AYX22_15665	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AYX22_15670	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AYX22_15675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AYX22_15680	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AYX22_15685	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AYX22_15690	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AYX22_15695	COG0255	Belongs to the universal ribosomal protein uL29 family
AYX22_15700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AYX22_15705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AYX22_15710	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AYX22_15715	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AYX22_15720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AYX22_15725	COG0089	rRNA binding
AYX22_15730	COG0088	Forms part of the polypeptide exit tunnel
AYX22_15735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AYX22_15740	COG0051	transcription antitermination factor activity, RNA binding
AYX22_15755	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AYX22_15760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AYX22_15765	COG0049	tRNA binding
AYX22_15770	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AYX22_15775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AYX22_15780	COG0085	RNA polymerase activity
AYX22_15785	COG0183	Belongs to the thiolase family
AYX22_15790	COG0442	prolyl-tRNA aminoacylation
AYX22_15795	COG0222	ribosome binding
AYX22_15800	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AYX22_15815	COG0081	regulation of translation
AYX22_15820	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AYX22_15830	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AYX22_15840	COG0436	Aminotransferase
AYX22_15845	COG2197	response regulator
AYX22_15895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AYX22_15905	COG3485	protocatechuate 3,4-dioxygenase
AYX22_15915	COG0745	RESPONSE REGULATOR receiver
AYX22_15920	COG0456	acetyltransferase
AYX22_15925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AYX22_15945	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AYX22_15950	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AYX22_15960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AYX22_15975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AYX22_15980	COG0738	Major facilitator superfamily
AYX22_15985	COG2030	dehydratase
AYX22_15990	COG2030	dehydratase
AYX22_16020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYX22_16030	COG4989	oxidoreductase activity
AYX22_16035	COG0366	Alpha amylase catalytic
AYX22_16040	COG0395	ABC-type sugar transport system, permease component
AYX22_16045	COG1175	transmembrane transport
AYX22_16055	COG1846	Transcriptional regulator
AYX22_16055	COG1940	carbohydrate kinase activity
AYX22_16065	COG0702	epimerase
AYX22_16110	COG0754	glutathionylspermidine amidase activity
AYX22_16120	COG5650	phosphatidylinositol metabolic process
AYX22_16140	COG1175	transmembrane transport
AYX22_16145	COG0395	ABC-type sugar transport system, permease component
AYX22_16175	COG1051	belongs to the nudix hydrolase family
AYX22_16210	COG0318	PFAM AMP-dependent synthetase and ligase
AYX22_16220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AYX22_16225	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AYX22_16225	COG5479	isomerase activity
AYX22_16230	COG1309	transcriptional regulator
AYX22_16235	COG1131	(ABC) transporter
AYX22_16255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AYX22_16270	COG1666	GTP binding
AYX22_16275	COG0501	Belongs to the peptidase M48B family
AYX22_16305	COG0531	amino acid
AYX22_16350	COG1012	belongs to the aldehyde dehydrogenase family
AYX22_16355	COG2508	Transcriptional regulator
AYX22_16360	COG2807	transmembrane transport
AYX22_16365	COG2186	Transcriptional regulator
AYX22_16370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYX22_16370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AYX22_16380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AYX22_16380	COG1648	precorrin-2 dehydrogenase activity
AYX22_16390	COG2066	Belongs to the glutaminase family
AYX22_16410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYX22_16435	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AYX22_16450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYX22_16455	COG1116	anion transmembrane transporter activity
AYX22_16465	COG2040	homocysteine
AYX22_16485	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYX22_16495	COG2860	membrane
AYX22_16510	COG0142	geranyltranstransferase activity
AYX22_16520	COG2226	methyltransferase
AYX22_16525	COG1169	isochorismate synthase
AYX22_16530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYX22_16535	COG0765	amino acid transport
AYX22_16545	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AYX22_16555	COG4948	Mandelate Racemase Muconate Lactonizing
AYX22_16575	COG1621	beta-fructofuranosidase activity
AYX22_16580	COG0395	ABC-type sugar transport system, permease component
AYX22_16585	COG1175	transmembrane transport
AYX22_16640	COG1404	Belongs to the peptidase S8 family
AYX22_16650	COG0662	Cupin 2, conserved barrel domain protein
AYX22_16670	COG1733	regulation of RNA biosynthetic process
AYX22_16720	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYX22_16725	COG0022	dehydrogenase e1 component
AYX22_16750	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AYX22_16790	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AYX22_16800	COG1134	teichoic acid transport
AYX22_16810	COG0438	transferase activity, transferring glycosyl groups
AYX22_16830	COG1316	TRANSCRIPTIONal
AYX22_16865	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AYX22_16875	COG1597	lipid kinase activity
AYX22_16880	COG1024	Enoyl-CoA hydratase
AYX22_16885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYX22_16890	COG2151	metal-sulfur cluster biosynthetic enzyme
AYX22_16895	COG3396	Phenylacetate-CoA oxygenase
AYX22_16900	COG3460	Phenylacetate-CoA oxygenase
AYX22_16905	COG3396	Phenylacetate-CoA oxygenase
AYX22_16915	COG1316	TRANSCRIPTIONal
AYX22_16980	COG0438	transferase activity, transferring glycosyl groups
AYX22_16995	COG2226	methyltransferase
AYX22_17005	COG5002	protein histidine kinase activity
AYX22_17025	COG2050	protein possibly involved in aromatic compounds catabolism
AYX22_17045	COG2030	dehydratase
AYX22_17045	COG1012	belongs to the aldehyde dehydrogenase family
AYX22_17050	COG1216	Glycosyl transferase, family 2
AYX22_17065	COG1609	Transcriptional regulator
AYX22_17070	COG2182	Extracellular solute-binding protein
AYX22_17080	COG0395	ABC-type sugar transport system, permease component
AYX22_17090	COG0673	inositol 2-dehydrogenase activity
AYX22_17100	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYX22_17105	COG1024	Enoyl-CoA hydratase
AYX22_17130	COG1022	Amp-dependent synthetase and ligase
AYX22_17155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYX22_17165	COG0488	(ABC) transporter
AYX22_17180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AYX22_17185	COG1121	(ABC) transporter
AYX22_17190	COG0803	Belongs to the bacterial solute-binding protein 9 family
AYX22_17195	COG1266	CAAX protease self-immunity
AYX22_17205	COG0395	ABC-type sugar transport system, permease component
AYX22_17210	COG1175	transmembrane transport
AYX22_17225	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AYX22_17275	COG0443	Heat shock 70 kDa protein
AYX22_17280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AYX22_17285	COG1333	cytochrome c biogenesis protein
AYX22_17290	COG0785	Cytochrome C biogenesis protein
AYX22_17300	COG0406	alpha-ribazole phosphatase activity
AYX22_17325	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AYX22_17350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AYX22_17355	COG3458	cephalosporin-C deacetylase activity
AYX22_17365	COG2755	lipolytic protein G-D-S-L family
AYX22_17370	COG0395	ABC-type sugar transport system, permease component
AYX22_17375	COG4209	transmembrane transport
AYX22_17380	COG1653	transport
AYX22_17385	COG5578	integral membrane protein
AYX22_17400	COG3250	beta-galactosidase activity
AYX22_17410	COG2814	Major facilitator Superfamily
AYX22_17420	COG0395	ABC-type sugar transport system, permease component
AYX22_17425	COG1175	transmembrane transport
AYX22_17445	COG0395	ABC-type sugar transport system, permease component
AYX22_17450	COG1175	transmembrane transport
AYX22_17475	COG4948	Mandelate Racemase Muconate Lactonizing
AYX22_17480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYX22_17490	COG0673	inositol 2-dehydrogenase activity
AYX22_17495	COG1609	Transcriptional regulator
AYX22_17500	COG1802	Transcriptional regulator
AYX22_17510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AYX22_17515	COG0640	Transcriptional regulator
AYX22_17525	COG0123	including yeast histone deacetylase and acetoin utilization protein
AYX22_17530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AYX22_17535	COG0569	domain protein
AYX22_17540	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AYX22_17545	COG1082	Xylose isomerase domain protein TIM barrel
AYX22_17550	COG0248	Ppx GppA phosphatase
AYX22_17560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AYX22_17560	COG1754	DNA topoisomerase type I activity
AYX22_17585	COG1054	Belongs to the UPF0176 family
AYX22_17595	COG1111	helicase
AYX22_17595	COG1205	dead DEAH box helicase
AYX22_17660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYX22_17665	COG1349	DNA-binding transcription factor activity
AYX22_17680	COG1609	Transcriptional regulator
AYX22_17690	COG1175	transmembrane transport
AYX22_17695	COG0395	ABC-type sugar transport system, permease component
AYX22_17710	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AYX22_17735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AYX22_17740	COG1408	metallophosphoesterase
AYX22_17745	COG1132	(ABC) transporter
AYX22_17750	COG1132	(ABC) transporter
AYX22_17865	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AYX22_17895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AYX22_17950	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AYX22_17955	COG0151	Belongs to the GarS family
AYX22_17970	COG1301	dicarboxylic acid transport
AYX22_17975	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_17985	COG1953	Uracil, thiamine, allantoin
AYX22_17990	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AYX22_18005	COG0454	-acetyltransferase
AYX22_18010	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AYX22_18020	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AYX22_18020	COG3608	succinylglutamate desuccinylase aspartoacylase
AYX22_18025	COG2252	PERMEase
AYX22_18030	COG0590	tRNA wobble adenosine to inosine editing
AYX22_18060	COG2233	PERMEase
AYX22_18070	COG1414	Transcriptional regulator
AYX22_18080	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AYX22_18090	COG3257	ureidoglycine aminohydrolase activity
AYX22_18110	COG0395	ABC-type sugar transport system, permease component
AYX22_18120	COG1653	transport
AYX22_18130	COG3119	arylsulfatase activity
AYX22_18135	COG1609	Transcriptional regulator
AYX22_18145	COG2318	DinB family
AYX22_18175	COG2271	Major facilitator Superfamily
AYX22_18190	COG4499	WXG100 protein secretion system (Wss), protein YukC
AYX22_18190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AYX22_18195	COG1053	succinate dehydrogenase
AYX22_18205	COG0673	inositol 2-dehydrogenase activity
AYX22_18210	COG0477	Major facilitator Superfamily
AYX22_18215	COG1414	Transcriptional regulator
AYX22_18220	COG0583	DNA-binding transcription factor activity
AYX22_18230	COG1063	alcohol dehydrogenase
AYX22_18235	COG1053	succinate dehydrogenase
AYX22_18260	COG0659	secondary active sulfate transmembrane transporter activity
AYX22_18275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AYX22_18285	COG0563	adenylate kinase activity
AYX22_18310	COG0477	Major facilitator Superfamily
AYX22_18320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AYX22_18330	COG3401	FG-GAP repeat protein
AYX22_18335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYX22_18345	COG0477	Major facilitator Superfamily
AYX22_18355	COG2011	ABC-type metal ion transport system permease component
AYX22_18360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AYX22_18365	COG1464	Belongs to the NlpA lipoprotein family
AYX22_18370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYX22_18380	COG0667	Aldo Keto reductase
AYX22_18455	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AYX22_18460	COG1733	regulation of RNA biosynthetic process
AYX22_18465	COG2267	carboxylic ester hydrolase activity
AYX22_18505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AYX22_18510	COG1024	Enoyl-CoA hydratase
AYX22_18515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AYX22_18595	COG1942	4-Oxalocrotonate Tautomerase
AYX22_18645	COG0405	Gamma-glutamyltransferase
AYX22_18690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AYX22_18715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYX22_18725	COG0583	DNA-binding transcription factor activity
AYX22_18760	COG0673	inositol 2-dehydrogenase activity
AYX22_18775	COG1653	transport
AYX22_18780	COG1609	Transcriptional regulator
AYX22_18795	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AYX22_18805	COG3622	Belongs to the hyi family
AYX22_18810	COG2084	Dehydrogenase
AYX22_18815	COG3960	tartronate-semialdehyde synthase activity
AYX22_18820	COG1929	Belongs to the glycerate kinase type-1 family
AYX22_18825	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AYX22_18830	COG0745	RESPONSE REGULATOR receiver
AYX22_18840	COG0745	RESPONSE REGULATOR receiver
AYX22_18850	COG1366	Belongs to the anti-sigma-factor antagonist family
AYX22_18875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AYX22_18880	COG2814	Major facilitator Superfamily
AYX22_18890	COG0671	phosphoesterase, PA-phosphatase related
AYX22_18915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AYX22_18940	COG0542	response to heat
AYX22_18970	COG4585	Histidine kinase
AYX22_18975	COG2197	response regulator
AYX22_19005	COG3304	Inner membrane component domain
AYX22_19015	COG0135	phosphoribosylanthranilate isomerase activity
AYX22_19035	COG0667	Aldo Keto reductase
AYX22_19070	COG1473	amidohydrolase
AYX22_19075	COG0477	Major facilitator Superfamily
AYX22_19080	COG2807	transmembrane transport
AYX22_19085	COG0259	pyridoxamine-phosphate oxidase activity
AYX22_19090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AYX22_19130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AYX22_19140	COG2188	Transcriptional regulator
AYX22_19160	COG1609	Transcriptional regulator
AYX22_19170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AYX22_19175	COG1653	transport
AYX22_19180	COG1175	transmembrane transport
AYX22_19185	COG0395	ABC-type sugar transport system, permease component
AYX22_19205	COG0154	amidase activity
AYX22_19210	COG2957	Belongs to the agmatine deiminase family
AYX22_19240	COG0789	Transcriptional regulator
AYX22_19245	COG0484	heat shock protein binding
AYX22_19250	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AYX22_19255	COG0443	Heat shock 70 kDa protein
AYX22_19265	COG3739	integral membrane protein
AYX22_19300	COG3540	Alkaline phosphatase
AYX22_19310	COG0436	Aminotransferase
AYX22_19340	COG3226	Transcriptional regulator
AYX22_19345	COG1280	lysine exporter protein (LysE YggA)
AYX22_19370	COG2409	Drug exporters of the RND superfamily
AYX22_19380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AYX22_19385	COG3795	YCII-related domain
AYX22_19390	COG4941	Belongs to the sigma-70 factor family
AYX22_19395	COG0667	Aldo Keto reductase
AYX22_19405	COG1280	lysine exporter protein (LysE YggA)
AYX22_19415	COG1609	Transcriptional regulator
AYX22_19420	COG1957	nucleoside hydrolase
AYX22_19425	COG0477	Major facilitator Superfamily
AYX22_19430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AYX22_19440	COG1309	transcriptional regulator
AYX22_19445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AYX22_19455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AYX22_19465	COG0833	amino acid
AYX22_19470	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AYX22_19480	COG2986	histidine ammonia-lyase
AYX22_19515	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AYX22_19520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AYX22_19555	COG1122	ATPase activity
AYX22_19560	COG4721	ABC-type cobalt transport system, permease component
AYX22_19575	COG1320	monovalent cation:proton antiporter activity
AYX22_19580	COG2212	antiporter activity
AYX22_19590	COG0651	ATP synthesis coupled electron transport
AYX22_19595	COG1006	Multisubunit Na H antiporter MnhC subunit
AYX22_19600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AYX22_19600	COG2111	Na H antiporter
AYX22_19615	COG0475	glutathione-regulated potassium exporter activity
AYX22_19625	COG0717	Belongs to the dCTP deaminase family
AYX22_19655	COG0686	Belongs to the AlaDH PNT family
AYX22_19665	COG0583	DNA-binding transcription factor activity
AYX22_19675	COG0640	Transcriptional regulator
AYX22_19690	COG0657	acetylesterase activity
AYX22_19690	COG2755	lipolytic protein G-D-S-L family
AYX22_19695	COG1609	Transcriptional regulator
AYX22_19700	COG0673	inositol 2-dehydrogenase activity
AYX22_19725	COG1940	carbohydrate kinase activity
AYX22_19730	COG2115	Belongs to the xylose isomerase family
AYX22_19735	COG1070	Carbohydrate kinase
AYX22_19740	COG1609	Transcriptional regulator
AYX22_19755	COG2160	L-arabinose isomerase activity
AYX22_19760	COG2017	converts alpha-aldose to the beta-anomer
AYX22_19770	COG3254	rhamnose metabolic process
AYX22_19780	COG3347	Dehydrogenase
AYX22_19780	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_19785	COG1070	Carbohydrate kinase
AYX22_19790	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AYX22_19800	COG3387	PFAM Glycoside hydrolase 15-related
AYX22_19805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYX22_19810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYX22_19815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AYX22_19835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYX22_19845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYX22_19855	COG1126	abc transporter atp-binding protein
AYX22_19860	COG0765	amino acid transport
AYX22_19875	COG0433	COG0433 Predicted ATPase
AYX22_19890	COG3336	cytochrome c oxidase
AYX22_19895	COG0776	regulation of translation
AYX22_19935	COG0596	Alpha beta hydrolase
AYX22_19940	COG3903	Transcriptional regulator
AYX22_19940	COG3629	intracellular signal transduction
AYX22_19965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AYX22_19970	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AYX22_19975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AYX22_20010	COG1120	ATPase activity
AYX22_20015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYX22_20020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYX22_20060	COG3012	SEC-C Motif Domain Protein
AYX22_20075	COG0667	Aldo Keto reductase
AYX22_20135	COG3550	peptidyl-serine autophosphorylation
AYX22_20150	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AYX22_20155	COG2186	Transcriptional regulator
AYX22_20165	COG1027	Aspartate ammonia-lyase
AYX22_20175	COG2186	Transcriptional regulator
AYX22_20190	COG3254	rhamnose metabolic process
AYX22_20200	COG4948	Mandelate Racemase Muconate Lactonizing
AYX22_20210	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_20215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYX22_20230	COG4221	oxidoreductase activity
AYX22_20240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYX22_20245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AYX22_20270	COG0640	Transcriptional regulator
AYX22_20285	COG1414	Transcriptional regulator
AYX22_20295	COG0477	Major facilitator Superfamily
AYX22_20305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AYX22_20330	COG1760	l-serine dehydratase
AYX22_20345	COG0281	malic enzyme
AYX22_20350	COG1309	transcriptional regulator
AYX22_20395	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AYX22_20400	COG0477	Major facilitator Superfamily
AYX22_20405	COG2986	histidine ammonia-lyase
AYX22_20410	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AYX22_20440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AYX22_20450	COG0477	Major facilitator Superfamily
AYX22_20455	COG2814	Major facilitator Superfamily
AYX22_20495	COG1113	amino acid transport
AYX22_20500	COG4604	ABC transporter, ATP-binding protein
AYX22_20505	COG4605	iron ion homeostasis
AYX22_20510	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYX22_20520	COG0246	Mannitol dehydrogenase
AYX22_20525	COG2213	PTS system mannitol-specific
AYX22_20525	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYX22_20535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AYX22_20540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYX22_20560	COG2267	carboxylic ester hydrolase activity
AYX22_20570	COG1793	dna ligase
AYX22_20585	COG0686	Belongs to the AlaDH PNT family
AYX22_20600	COG0673	inositol 2-dehydrogenase activity
AYX22_20625	COG1309	transcriptional regulator
AYX22_20655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYX22_20670	COG0531	amino acid
AYX22_20685	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYX22_20690	COG0022	dehydrogenase e1 component
AYX22_20700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AYX22_20705	COG1950	PFAM Membrane protein of
AYX22_20720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AYX22_20725	COG2826	transposase and inactivated derivatives, IS30 family
AYX22_20740	COG1607	acyl-coa hydrolase
AYX22_20750	COG4221	oxidoreductase activity
AYX22_20755	COG0477	Major facilitator Superfamily
AYX22_20760	COG1984	allophanate hydrolase subunit 2
AYX22_20765	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AYX22_20770	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AYX22_20775	COG0583	DNA-binding transcription factor activity
AYX22_20785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AYX22_20790	COG0436	Aminotransferase
AYX22_20815	COG3971	2-oxopent-4-enoate hydratase activity
AYX22_20830	COG1802	Transcriptional regulator
AYX22_20835	COG0179	Fumarylacetoacetate (FAA) hydrolase
AYX22_20850	COG2261	transglycosylase associated protein
AYX22_20860	COG2207	Transcriptional regulator
AYX22_20860	COG3708	Transcriptional regulator
AYX22_20870	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_20940	COG1609	Transcriptional regulator
AYX22_20945	COG1653	transport
AYX22_20955	COG0395	ABC-type sugar transport system, permease component
AYX22_20960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AYX22_20980	COG0515	serine threonine protein kinase
AYX22_21055	COG1396	sequence-specific DNA binding
AYX22_21065	COG0604	alcohol dehydrogenase
AYX22_21075	COG3387	PFAM Glycoside hydrolase 15-related
AYX22_21085	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AYX22_21105	COG1414	Transcriptional regulator
AYX22_21110	COG2814	Major facilitator Superfamily
AYX22_21145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AYX22_21155	COG2261	transglycosylase associated protein
AYX22_21160	COG0515	serine threonine protein kinase
AYX22_21170	COG1846	Transcriptional regulator
AYX22_21200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AYX22_21205	COG1760	l-serine dehydratase
AYX22_21210	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AYX22_21215	COG0509	glycine decarboxylation via glycine cleavage system
AYX22_21220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AYX22_21225	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AYX22_21225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AYX22_21230	COG1970	mechanosensitive ion channel activity
AYX22_21285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AYX22_21315	COG2814	Major facilitator Superfamily
AYX22_21340	COG0179	Fumarylacetoacetate (FAA) hydrolase
AYX22_21345	COG0251	oxidation-reduction process
AYX22_21355	COG1414	Transcriptional regulator
AYX22_21360	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYX22_21370	COG0183	Belongs to the thiolase family
AYX22_21375	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AYX22_21395	COG3485	protocatechuate 3,4-dioxygenase
AYX22_21405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AYX22_21410	COG1414	Transcriptional regulator
AYX22_21415	COG0477	Major facilitator Superfamily
AYX22_21430	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AYX22_21450	COG0583	DNA-binding transcription factor activity
AYX22_21490	COG0463	Glycosyl transferase, family 2
AYX22_21515	COG0366	Alpha amylase catalytic
AYX22_21530	COG2326	polyphosphate kinase activity
AYX22_21550	COG1737	Transcriptional regulator
AYX22_21555	COG3876	Protein conserved in bacteria
AYX22_21560	COG1472	Belongs to the glycosyl hydrolase 3 family
AYX22_21580	COG1175	transmembrane transport
AYX22_21585	COG1653	transport
AYX22_21615	COG1937	Protein conserved in bacteria
AYX22_21685	COG2259	Doxx family
AYX22_21695	COG1607	acyl-coa hydrolase
AYX22_21715	COG3958	Transketolase
AYX22_21720	COG3959	Transketolase, thiamine diphosphate binding domain
AYX22_21735	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_21740	COG2376	Dihydroxyacetone kinase
AYX22_21745	COG0698	ribose 5-phosphate isomerase
AYX22_21755	COG0305	Participates in initiation and elongation during chromosome replication
AYX22_21800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AYX22_21805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AYX22_21845	COG1414	Transcriptional regulator
AYX22_21860	COG0384	phenazine biosynthesis protein PhzF
AYX22_21870	COG0359	binds to the 23S rRNA
AYX22_21875	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AYX22_21885	COG0360	Binds together with S18 to 16S ribosomal RNA
AYX22_21890	COG1742	UPF0060 membrane protein
AYX22_21905	COG1113	amino acid transport
AYX22_21910	COG1362	aminopeptidase activity
AYX22_21930	COG1414	Transcriptional regulator
AYX22_21945	COG0833	amino acid
AYX22_21955	COG2197	response regulator
AYX22_21965	COG4974	Belongs to the 'phage' integrase family
AYX22_22155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYX22_22175	COG2211	Major facilitator Superfamily
AYX22_22185	COG1472	Belongs to the glycosyl hydrolase 3 family
AYX22_22195	COG0604	alcohol dehydrogenase
AYX22_22220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AYX22_22225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYX22_22235	COG0583	DNA-binding transcription factor activity
AYX22_22240	COG0477	Major facilitator Superfamily
AYX22_22250	COG0473	3-isopropylmalate dehydrogenase activity
AYX22_22260	COG0563	adenylate kinase activity
AYX22_22265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYX22_22275	COG0531	amino acid
AYX22_22425	COG0387	Pfam Sodium calcium exchanger
AYX22_22440	COG1253	flavin adenine dinucleotide binding
AYX22_22455	COG0586	Pfam SNARE associated Golgi protein
AYX22_22505	COG2963	transposase activity
AYX22_22555	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AYX22_22565	COG0659	secondary active sulfate transmembrane transporter activity
AYX22_22570	COG0789	Transcriptional regulator
AYX22_22575	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AYX22_22590	COG0789	Transcriptional regulator
AYX22_22595	COG0659	secondary active sulfate transmembrane transporter activity
AYX22_22600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AYX22_22610	COG0477	Major facilitator Superfamily
AYX22_22625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AYX22_22625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AYX22_22630	COG4232	protein-disulfide reductase activity
AYX22_22640	COG2188	Transcriptional regulator
AYX22_22665	COG1937	Protein conserved in bacteria
AYX22_22685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AYX22_22700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYX22_22705	COG2814	Major facilitator Superfamily
AYX22_22905	COG2217	Heavy metal translocating P-type atpase
AYX22_22925	COG0640	Transcriptional regulator
AYX22_22935	COG0640	Transcriptional regulator
AYX22_22975	COG1937	Protein conserved in bacteria
AYX22_22980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AYX22_22995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AYX22_23000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYX22_23010	COG0586	Pfam SNARE associated Golgi protein
AYX22_23015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AYX22_23030	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AYX22_23060	COG2205	protein histidine kinase activity
AYX22_23065	COG0745	RESPONSE REGULATOR receiver
AYX22_23075	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AYX22_23080	COG0586	Pfam SNARE associated Golgi protein
AYX22_23110	COG0789	Transcriptional regulator
AYX22_23210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AYX22_23215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AYX22_23225	COG0492	ferredoxin-NADP+ reductase activity
AYX22_23230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AYX22_23250	COG0456	acetyltransferase
AYX22_23335	COG3336	cytochrome c oxidase
AYX22_23340	COG0640	Transcriptional regulator
AYX22_23360	COG0739	heme binding
AYX22_23375	COG3118	belongs to the thioredoxin family
AYX22_23380	COG0785	Cytochrome C biogenesis protein
AYX22_23385	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AYX22_23410	COG1321	iron dependent repressor
AYX22_23455	COG1793	dna ligase
AYX22_23510	COG1475	DNA binding
AYX22_23570	COG0512	Glutamine amidotransferase of anthranilate synthase
AYX22_23590	COG2124	cytochrome p450
AYX22_23595	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AYX22_23600	COG1028	Short-chain dehydrogenase reductase Sdr
AYX22_23610	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AYX22_23625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AYX22_23630	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AYX22_23635	COG1012	belongs to the aldehyde dehydrogenase family
AYX22_23640	COG1473	amidohydrolase
AYX22_23760	COG1192	Involved in chromosome partitioning
AYX22_23815	COG1061	Type III restriction enzyme res subunit