locus-tag class description Arth_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Arth_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Arth_0003 ENOG4108J5G 6-phosphogluconate dehydrogenase Arth_0004 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Arth_0005 ENOG4105K7N UPF0232 protein Arth_0006 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Arth_0007 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Arth_0008 ENOG4108ZED Transmembrane domain of unknown function (DUF3566) Arth_0010 ENOG4105CKK Glycosyl transferase, family 2 Arth_0014 ENOG4108R3E Dna-3-methyladenine glycosylase i Arth_0015 ENOG4107G87 m6 family metalloprotease domain protein Arth_0017 ENOG4108U4N (sortase) family Arth_0020 ENOG4105D9P serine threonine protein kinase Arth_0021 ENOG4107TPY serine threonine protein kinase Arth_0022 ENOG4105CJN penicillin-binding protein Arth_0025 ENOG4105HZM Fha domain containing protein Arth_0026 ENOG4105TV9 FHA Domain-Containing protein Arth_0028 ENOG4105D7T ABC transporter Arth_0030 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component Arth_0031 ENOG4105CMD Transcriptional regulator, GntR family Arth_0032 ENOG4105DIA mandelate racemase muconate lactonizing Arth_0035 ENOG4105EQX glucarate dehydratase Arth_0035 ENOG4105EQX glucarate dehydratase Arth_0037 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase Arth_0038 ENOG4106NZI LysR family Transcriptional regulator Arth_0052 ENOG4105ETE Transcriptional regulator (LacI family Arth_0053 ENOG4105D7K pfkb domain protein Arth_0054 ENOG4108HKT sucrose-6-phosphate hydrolase Arth_0062 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Arth_0072 ENOG4108TCJ secreted hydrolase Arth_0079 ENOG4107T5V SNARE associated Golgi Arth_0080 ENOG4105ETE Transcriptional regulator (LacI family Arth_0081 ENOG4105DU0 nucleoside hydrolase Arth_0083 ENOG4108RVA ribokinase Arth_0089 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Arth_0091 ENOG4105ETE Transcriptional regulator (LacI family Arth_0092 ENOG41073TP transcriptional regulator Arth_0093 ENOG4105E7W lamb ycsf family protein Arth_0094 ENOG4105CSH Transporter Arth_0096 ENOG4108JIK carboxylase Arth_0102 ENOG4105C09 Bile acid Arth_0104 ENOG4105CHH sulfate transporter Arth_0107 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Arth_0108 ENOG4107TPS domain protein Arth_0111 ENOG410667J hydrolase Arth_0112 ENOG4107VXM glycerophosphoryl diester phosphodiesterase Arth_0113 ENOG4105BZU Histidine kinase Arth_0116 ENOG4105BZU Histidine kinase Arth_0118 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) Arth_0119 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) Arth_0120 ENOG4105CVJ phosphoglycerate mutase Arth_0122 ENOG4108MUZ hydrolase Arth_0123 ENOG4105BZW Glycerate kinase Arth_0126 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Arth_0128 ENOG4105C2W permease Arth_0129 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) Arth_0134 ENOG4105DUX Transporter Arth_0136 ENOG4105EC3 peptidase S51, dipeptidase E Arth_0137 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) Arth_0139 ENOG4107TE5 Lipid kinase Arth_0140 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Arth_0141 ENOG410667J hydrolase Arth_0145 ENOG4105EBR Carboxylesterase Arth_0149 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Arth_0151 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Arth_0152 ENOG4105EUJ GTP cyclohydrolase i Arth_0153 ENOG4105EEI dihydropteroate synthase Arth_0155 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Arth_0160 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Arth_0165 ENOG4105CRK lysyL-tRNA synthetase Arth_0168 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Arth_0169 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein Arth_0172 ENOG4105CMT Dihydroxyacetone kinase Arth_0173 ENOG4108UTZ Dihydroxyacetone kinase Arth_0180 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) Arth_0181 ENOG4105CE4 GlcNAc 6-P deacetylase Arth_0182 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) Arth_0183 ENOG4105DKQ ROK family Arth_0184 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Arth_0185 ENOG4108JQ7 (ABC) transporter Arth_0186 ENOG4105C3U ABC transporter Arth_0188 ENOG4105DEF Extracellular solute-binding protein, family 5 Arth_0190 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) Arth_0191 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Arth_0192 ENOG4105D9P serine threonine protein kinase Arth_0196 ENOG4108M6P methyltransferase Arth_0198 ENOG4107STQ Multicopper oxidase Arth_0205 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Arth_0206 ENOG4105CJ3 phosphate transporter Arth_0214 ENOG4105C3M thioredoxin reductase Arth_0218 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b Arth_0219 ENOG4105ETE Transcriptional regulator (LacI family Arth_0222 ENOG4105EF1 ribulokinase Arth_0224 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) Arth_0225 ENOG4105C0H protease Arth_0228 ENOG4105ETE Transcriptional regulator (LacI family Arth_0229 ENOG4105EKT )-iron permease Arth_0230 ENOG410650H (LipO)protein Arth_0231 ENOG4105DBE peroxidase Arth_0234 ENOG4105DIA mandelate racemase muconate lactonizing Arth_0235 ENOG4108PVQ transcriptional regulator Arth_0236 ENOG4105DJB Major Facilitator Superfamily Arth_0238 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN Arth_0241 ENOG4108YZ9 Urea amidohydrolase subunit gamma Arth_0242 ENOG4105KI2 Urea amidohydrolase subunit beta Arth_0243 ENOG4105CQM Urea amidohydrolase subunit alpha Arth_0244 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) Arth_0245 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Arth_0246 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) Arth_0247 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Arth_0248 ENOG4105D9G High-affinity Arth_0253 ENOG4105CI2 imidazolone-5-propionate hydrolase Arth_0255 ENOG4105DQ4 alcohol dehydrogenase Arth_0257 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Arth_0258 ENOG4105E2K Glycosyl transferase (Group 1 Arth_0261 ENOG4105Y3U Transglycosylase-associated protein Arth_0264 ENOG4105CPC Aldo Keto reductase Arth_0265 ENOG4105CV8 reductase Arth_0268 ENOG4105WKW Pfam:DUF1458 Arth_0270 ENOG4105XTG Pfam:DUF156 Arth_0271 ENOG4107EJG GntR family transcriptional regulator Arth_0273 ENOG4105ZXK Dehydrogenase Arth_0274 ENOG4105C6Z Gluconate Arth_0281 ENOG4107QZ7 Cellulose synthase catalytic subunit Arth_0283 ENOG4105WN5 stage II sporulation protein Arth_0286 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) Arth_0288 ENOG4105DUU IucA IucC family protein Arth_0289 ENOG4108W6C Dehydrogenase Arth_0291 ENOG4105CSH Transporter Arth_0295 ENOG4105FDF Could be involved in DNA repair (By similarity) Arth_0299 ENOG4105DM4 PTS System Arth_0300 ENOG4105DE4 1-phosphofructokinase Arth_0301 ENOG410804X Transcriptional regulator Arth_0304 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Arth_0306 ENOG4105ETE Transcriptional regulator (LacI family Arth_0307 ENOG4107UVD Beta-phosphoglucomutase family hydrolase Arth_0313 ENOG4105E7W lamb ycsf family protein Arth_0315 ENOG4108IUE nitrate reductase beta subunit Arth_0319 ENOG4106BRA Membrane Arth_0321 ENOG4105DIM ABC transporter Arth_0322 ENOG4105CIG ABC transporter Arth_0334 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction Arth_0345 ENOG4107S2Z UPF0761 membrane protein Arth_0352 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase Arth_0355 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Arth_0356 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) Arth_0357 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) Arth_0358 ENOG4106517 Short-chain dehydrogenase reductase Sdr Arth_0361 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) Arth_0367 ENOG410829K Lysine exporter protein (Lyse ygga) Arth_0369 ENOG4105C85 amino acid Arth_0374 ENOG4105CGP Urocanate hydratase Arth_0375 ENOG4105C84 Histidine ammonia-lyase Arth_0378 ENOG4108NQD Arth_0379 ENOG41088SP formiminoglutamate hydrolase Arth_0380 ENOG4105C7N Xanthine uracil vitamin C permease Arth_0384 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Arth_0388 ENOG4105K4H Nlp p60 protein Arth_0391 ENOG4107Y9U Membrane Arth_0393 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) Arth_0395 ENOG4105DCG PHP domain protein Arth_0396 ENOG4108YV4 Universal stress protein Arth_0397 ENOG4105ETE Transcriptional regulator (LacI family Arth_0399 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Arth_0400 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Arth_0403 ENOG4108HKT sucrose-6-phosphate hydrolase Arth_0405 ENOG4105EDQ levansucrase EC 2.4.1.10 Arth_0407 ENOG4105VBF alkaline shock protein Arth_0412 ENOG4105CG3 alpha amylase, catalytic region Arth_0417 ENOG4105ETE Transcriptional regulator (LacI family Arth_0418 ENOG4108TAC Arth_0420 ENOG4105C26 Dehydrogenase Arth_0421 ENOG4105E39 Enoyl-CoA hydratase Arth_0424 ENOG4105D7K pfkb domain protein Arth_0425 ENOG4108HKT sucrose-6-phosphate hydrolase Arth_0427 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Arth_0429 ENOG4105ETE Transcriptional regulator (LacI family Arth_0430 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Arth_0433 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Arth_0434 ENOG4105C1G acyl-Coa dehydrogenase Arth_0435 ENOG4105NAE bifunctional deaminase-reductase domain protein Arth_0436 ENOG4105MCD Part of cytochrome c oxidase, its function is Arth_0442 ENOG4108J2P Alpha beta hydrolase fold Arth_0466 ENOG4108C33 Resolvase Arth_0472 ENOG4105VEQ Cold shock protein Arth_0474 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Arth_0476 ENOG4105BZU Histidine kinase Arth_0479 ENOG4105EQX glucarate dehydratase Arth_0480 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Arth_0485 ENOG4105WH1 Two component transcriptional regulator luxr family Arth_0486 ENOG4105BZU Histidine kinase Arth_0489 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Arth_0495 ENOG4105ETE Transcriptional regulator (LacI family Arth_0498 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component Arth_0500 ENOG4105CK5 oxidoreductase Arth_0502 ENOG4105D2H Uronic isomerase Arth_0503 ENOG4105DEI Mannitol dehydrogenase Arth_0504 ENOG4105CXK mandelate racemase muconate lactonizing Arth_0505 ENOG4105D17 glycoside hydrolase, family 3 domain protein Arth_0512 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Arth_0517 ENOG4108JEZ rRNA small subunit methyltransferase G Arth_0518 ENOG4107RCW fructose-bisphosphate aldolase Arth_0522 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Arth_0526 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Arth_0530 ENOG4105K4P CoA-binding domain protein Arth_0532 ENOG4105FBW Monooxygenase Arth_0533 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Arth_0534 ENOG4105K4P CoA-binding domain protein Arth_0535 ENOG4105MSB protein, conserved in bacteria Arth_0536 ENOG4105PMW Domain of unknown function (DUF1990) Arth_0540 ENOG4107QIK phosphoribosylformylglycinamidine synthase Arth_0541 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Arth_0544 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin Arth_0549 ENOG4105K56 Transcriptional regulator Arth_0552 ENOG4105CFH Aspartokinase Arth_0553 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Arth_0554 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Arth_0556 ENOG4105EGD dinuclear metal center protein, YbgI family Arth_0558 ENOG4105E4C Lytic transglycosylase catalytic Arth_0559 ENOG4108V06 Glutathione peroxidase Arth_0560 ENOG4105E2A Dehydrogenase Arth_0561 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) Arth_0566 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) Arth_0570 ENOG4108MR6 WD40-like Beta Propeller Repeat Arth_0573 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Arth_0575 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Arth_0580 ENOG4105E2R ROK family Arth_0582 ENOG4107R9S Malate synthase Arth_0584 ENOG4108IMY Transcriptional regulator Arth_0586 ENOG4105DHQ Histidine kinase Arth_0587 ENOG4108KXV response regulator Arth_0588 ENOG4105CSH Transporter Arth_0589 ENOG4107SVN transposase Arth_0590 ENOG4105C7K acetolactate synthase Arth_0593 ENOG4105DWF phosphomethylpyrimidine kinase Arth_0594 ENOG4105ECP epimerase Arth_0599 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Arth_0605 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Arth_0610 ENOG4105C1G acyl-Coa dehydrogenase Arth_0614 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) Arth_0617 ENOG4108W1A pseudouridine synthase Arth_0620 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Arth_0621 ENOG4108VW9 Membrane Arth_0622 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) Arth_0623 ENOG4107QRT dEAD DEAH box helicase Arth_0631 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Arth_0638 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) Arth_0640 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Arth_0644 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Arth_0645 ENOG4108Z6B deaminase Arth_0646 ENOG410841Q phosphoesterase PA-phosphatase related protein Arth_0647 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Arth_0654 ENOG4105BZU Histidine kinase Arth_0655 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Arth_0659 ENOG4105M4E phosphohistidine phosphatase, SixA Arth_0661 ENOG4108594 Permease of the drug metabolite transporter Arth_0662 ENOG4108IG5 Transcriptional regulator Arth_0663 ENOG4105ECB domain protein Arth_0665 ENOG4107QN2 dihydrolipoyl dehydrogenase Arth_0666 ENOG41073TP transcriptional regulator Arth_0667 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) Arth_0669 ENOG4105KPV Transcriptional regulator Arth_0672 ENOG4105C9U ATP-dependent DNA helicase RecQ Arth_0673 ENOG4105C0R drug resistance transporter emrb qaca subfamily Arth_0679 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Arth_0681 ENOG4105D22 carbon starvation protein Arth_0685 ENOG4105CV8 reductase Arth_0699 ENOG41087YS Phage shock protein A Arth_0716 ENOG4105C6E dna polymerase iii Arth_0717 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Arth_0721 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Arth_0723 ENOG4105BZU Histidine kinase Arth_0727 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) Arth_0728 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Arth_0730 ENOG4105C8N cysteinyl-tRNA synthetase Arth_0737 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) Arth_0738 ENOG4105CG3 alpha amylase, catalytic region Arth_0739 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Arth_0742 ENOG4105ETE Transcriptional regulator (LacI family Arth_0743 ENOG4105CG3 alpha amylase, catalytic region Arth_0745 ENOG4105D56 permease protein Arth_0746 ENOG4105EG2 ABC transporter, permease Arth_0747 ENOG4107R28 alpha amylase, catalytic region Arth_0748 ENOG4105CQB FAD linked oxidase domain protein Arth_0750 ENOG4108IJ9 (ABC) transporter Arth_0758 ENOG4105D5Q Arginine ornithine antiporter Arth_0759 ENOG4105DWY Agmatine deiminase Arth_0761 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction Arth_0762 ENOG4105C57 major facilitator superfamily Arth_0764 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Arth_0765 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Arth_0767 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Arth_0769 ENOG4105KAV tspo and mbr like protein Arth_0774 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) Arth_0777 ENOG4105VEQ Cold shock protein Arth_0779 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Arth_0783 ENOG4105BZU Histidine kinase Arth_0784 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Arth_0790 ENOG4105VEQ Cold shock protein Arth_0792 ENOG4105E8G Major facilitator Superfamily Arth_0793 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) Arth_0795 ENOG4105DR5 peptidase Arth_0799 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) Arth_0802 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Arth_0807 ENOG4105BZ1 (ABC) transporter Arth_0812 ENOG4105ECY inositol monophosphatase Arth_0815 ENOG4105CMV Succinyl-CoA synthetase subunit beta Arth_0818 ENOG4105NPE arsR family transcriptional regulator Arth_0819 ENOG41090U3 tautomerase Arth_0820 ENOG4105D7K pfkb domain protein Arth_0822 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) Arth_0823 ENOG4105C26 Dehydrogenase Arth_0825 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Arth_0826 ENOG4105F0H myo-inositol catabolism protein Arth_0827 ENOG4107QNK )-transporter Arth_0828 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) Arth_0829 ENOG4105F27 Major Facilitator Arth_0831 ENOG41062B0 ABC transporter, permease Arth_0832 ENOG4105C2J ABC transporter Arth_0833 ENOG4105CK5 oxidoreductase Arth_0834 ENOG4105CK5 oxidoreductase Arth_0835 ENOG4105DH8 myo-inositol catabolism Arth_0836 ENOG4108X79 transcriptional regulator Arth_0837 ENOG4108Z86 Glutamine amidotransferase Arth_0839 ENOG4105JXH GntR family transcriptional regulator Arth_0847 ENOG4108JCI Transcriptional regulator Arth_0850 ENOG4108YZA Nitrogen regulatory protein pii Arth_0852 ENOG4105C7K acetolactate synthase Arth_0862 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 Arth_0866 ENOG4105BZU Histidine kinase Arth_0867 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Arth_0871 ENOG4108K2F hydrolase Family 5 Arth_0875 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) Arth_0878 ENOG4107RR1 TRANSCRIPTIONal Arth_0881 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Arth_0884 ENOG4105CMT Dihydroxyacetone kinase Arth_0885 ENOG4107YVI ribose 5-phosphate isomerase Arth_0886 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Arth_0888 ENOG4105CSP Major Facilitator Superfamily Arth_0889 ENOG4105CP7 Triose-phosphate isomerase Arth_0902 ENOG4108535 NAD dependent epimerase/dehydratase family Arth_0910 ENOG4105CPC Aldo Keto reductase Arth_0913 ENOG4105CG3 alpha amylase, catalytic region Arth_0918 ENOG41086X7 Acylphosphatase Arth_0924 ENOG4105VMP Transcriptional regulator Arth_0928 ENOG41080V3 Major Facilitator superfamily Arth_0933 ENOG4108XZR Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) Arth_0948 ENOG4105C9U ATP-dependent DNA helicase RecQ Arth_0950 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Arth_0955 ENOG4105CUZ uba thif-type nad fad binding protein Arth_0966 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) Arth_0967 ENOG4105CBD Diacylglycerol kinase Arth_0969 ENOG4105C7K acetolactate synthase Arth_0971 ENOG4105CIH Imidazole acetol-phosphate transaminase Arth_0972 ENOG4105C85 amino acid Arth_0986 ENOG4105DZR Type I site-specific deoxyribonuclease Arth_0988 ENOG4105CVR type I restriction-modification system Arth_0993 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Arth_1002 ENOG4105D9P serine threonine protein kinase Arth_1009 ENOG41080E2 ribosomal-protein-alanine acetyltransferase Arth_1010 ENOG4108RVA ribokinase Arth_1012 ENOG4105DU0 nucleoside hydrolase Arth_1014 ENOG4105C6F GntR Family Transcriptional Regulator Arth_1018 ENOG4105KWG Pfam:DUF1696 Arth_1022 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Arth_1023 ENOG4105E98 transcriptional regulator DeoR family Arth_1029 ENOG4105K9H YciI-like protein Arth_1033 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 Arth_1034 ENOG4105E98 transcriptional regulator DeoR family Arth_1035 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) Arth_1036 ENOG4105DEF Extracellular solute-binding protein, family 5 Arth_1037 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Arth_1038 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Arth_1041 ENOG4105CPC Aldo Keto reductase Arth_1042 ENOG4105CNV Aldolase Arth_1044 ENOG4105F6U Short-chain dehydrogenase reductase Sdr Arth_1045 ENOG4105DGI Alkaline phosphatase Arth_1055 ENOG4105VEQ Cold shock protein Arth_1058 ENOG4105D9R oxidoreductase Arth_1063 ENOG4105H3G oxidoreductase Arth_1065 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Arth_1069 ENOG4105C6Y Udp-glucose 6-dehydrogenase Arth_1073 ENOG4105DZ6 Band 7 protein Arth_1075 ENOG4108Z4U Ferredoxin Arth_1076 ENOG4105C26 Dehydrogenase Arth_1080 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Arth_1082 ENOG4105CSH Transporter Arth_1083 ENOG4108JCI Transcriptional regulator Arth_1089 ENOG4105C54 Major Facilitator superfamily Arth_1090 ENOG4105DC1 bifunctional purine biosynthesis protein purh Arth_1092 ENOG4105E9K Isocitrate dehydrogenase Arth_1096 ENOG4105D9P serine threonine protein kinase Arth_1100 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Arth_1102 ENOG4105DFW ABC transporter Arth_1103 ENOG41062B0 ABC transporter, permease Arth_1106 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) Arth_1108 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Arth_1109 ENOG4105CUB amino acid Arth_1111 ENOG4108Z0R Transferase Arth_1116 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Arth_1117 ENOG4105CJ1 ABC, transporter Arth_1121 ENOG4105CGK Exodeoxyribonuclease III Arth_1122 ENOG4105C31 Tryptophanyl-tRNA synthetase Arth_1128 ENOG4105E33 succinate dehydrogenase Arth_1133 ENOG4107RM1 amidohydrolase Arth_1134 ENOG4105K56 Transcriptional regulator Arth_1135 ENOG4108ZHJ Organic hydroperoxide resistance protein Arth_1136 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein Arth_1137 ENOG4105DIH basic membrane Arth_1138 ENOG4108JQ9 ABC transporter Arth_1139 ENOG4105UIB (ABC) transporter Arth_1144 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN Arth_1145 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) Arth_1146 ENOG4105DXN mazG family Arth_1147 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Arth_1151 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Arth_1155 ENOG4108IV0 ABC, transporter Arth_1156 ENOG4105C0Z ABC transporter Arth_1157 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Arth_1158 ENOG4105C32 Amino acid ABC transporter (Permease) Arth_1160 ENOG4105CHU acetyl-coa acetyltransferase Arth_1161 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) Arth_1163 ENOG4107WI4 Aldose-1-epimerase Arth_1165 ENOG4105C7B Threonine dehydratase Arth_1167 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Arth_1169 ENOG4105T1M mycothiol conjugate amidase mca Arth_1171 ENOG4105C7Z Conserved Protein Arth_1172 ENOG4108UT2 hemolysin iii Arth_1173 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Arth_1174 ENOG4108IAB Phoh family Arth_1180 ENOG41060BG Tetr family transcriptional regulator Arth_1181 ENOG4105C9Q fumarate hydratase class II Arth_1182 ENOG4108V9Q carbonic anhydrase Arth_1186 ENOG4105EIP mannose-6-phosphate isomerase Arth_1188 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Arth_1192 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Arth_1193 ENOG4107RGC Glycosyl transferase, family 2 Arth_1198 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) Arth_1200 ENOG41069FZ L,D-transpeptidase catalytic domain Arth_1208 ENOG4105F8C transglutaminase domain-containing protein Arth_1210 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Arth_1211 ENOG4105F8V Hydrolase, tatD family Arth_1212 ENOG4106839 domain protein Arth_1213 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Arth_1214 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Arth_1215 ENOG4105C5H ABC transporter Arth_1216 ENOG41067SE Tetr family transcriptional regulator Arth_1217 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Arth_1219 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Arth_1220 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Arth_1225 ENOG4107QQG Dehydrogenase Arth_1226 ENOG4108IAJ Nad-dependent epimerase dehydratase Arth_1227 ENOG4108SHJ s-layer protein Arth_1229 ENOG4108NNZ chitinase Arth_1232 ENOG4107R8N Glycosyl transferase, family 2 Arth_1236 ENOG4108UNV SUF system FeS assembly protein, NifU family Arth_1239 ENOG4108RJ9 Glycosyl transferase, family 2 Arth_1242 ENOG4105CGD Nad-dependent epimerase dehydratase Arth_1246 ENOG4107K5X Membrane-bound metal-dependent hydrolase Arth_1248 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) Arth_1249 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase Arth_1257 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Arth_1258 ENOG4107QZF nitrite reductase NADPH large subunit Arth_1260 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain Arth_1267 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Arth_1268 ENOG4107QND Nitrite extrusion protein Arth_1269 ENOG4105CSH Transporter Arth_1271 ENOG4108JIK carboxylase Arth_1272 ENOG4107WR6 Maf-like protein Arth_1275 ENOG4105EYF MMPL domain protein Arth_1278 ENOG4108ETY sodium dicarboxylate symporter Arth_1281 ENOG4105D8K carboxyl transferase Arth_1282 ENOG4105H9W Short-chain dehydrogenase reductase Sdr Arth_1283 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase Arth_1288 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Arth_1292 ENOG4108ZF3 Phosphatase Arth_1296 ENOG4105EC2 ftsk spoIIIe Arth_1298 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Arth_1300 ENOG4105CPU Monooxygenase Arth_1302 ENOG4108176 endoribonuclease L-psp Arth_1303 ENOG4108MRH transcriptional regulatory protein Arth_1304 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism Arth_1305 ENOG4105D4T Citrate transporter Arth_1306 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Arth_1307 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Arth_1308 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Arth_1310 ENOG4105CPQ Dehydrogenase Arth_1311 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Arth_1313 ENOG4105CI2 imidazolone-5-propionate hydrolase Arth_1314 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Arth_1317 ENOG4108IQK o-acetylhomoserine Arth_1318 ENOG4105DWV Homoserine O-trans-acetylase Arth_1323 ENOG4105C26 Dehydrogenase Arth_1327 ENOG4105FBA Phospholipase Carboxylesterase Arth_1330 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) Arth_1332 ENOG4107RIS Acyl-transferase Arth_1337 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Arth_1338 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Arth_1341 ENOG4105C2C drug resistance transporter, Bcr CflA Arth_1343 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Arth_1365 ENOG4105C1G acyl-Coa dehydrogenase Arth_1367 ENOG4105CE9 30S ribosomal protein S2 Arth_1368 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Arth_1369 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Arth_1370 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Arth_1375 ENOG4108NEV two component transcriptional regulator, LytTR family Arth_1376 ENOG4108HRK Histidine kinase Arth_1378 ENOG4107QN1 sodium solute Arth_1382 ENOG4105CPP Dehydrogenase, E1 component Arth_1383 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 Arth_1385 ENOG4107QX3 carboxylase Arth_1387 ENOG4105C1G acyl-Coa dehydrogenase Arth_1392 ENOG4105SHT UspA domain-containing protein Arth_1396 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism Arth_1397 ENOG4108MRH transcriptional regulatory protein Arth_1399 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Arth_1400 ENOG4105DZP Membrane-associated zinc metalloprotease Arth_1404 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Arth_1407 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Arth_1413 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) Arth_1416 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Arth_1417 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Arth_1419 ENOG4107Y2X deaminase Arth_1420 ENOG4105K63 Thioredoxin Arth_1423 ENOG4105CHM Aminotransferase Arth_1424 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Arth_1431 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) Arth_1433 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Arth_1434 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Arth_1435 ENOG4105C1V Peptidase, M16 Arth_1441 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Arth_1442 ENOG4105EB3 Histidine kinase Arth_1446 ENOG4108RIR Molybdenum cofactor biosynthesis protein Arth_1448 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Arth_1452 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Arth_1453 ENOG4105CN5 Metallo-Beta-Lactamase Arth_1454 ENOG4107QZI cell division protein FtsK Arth_1456 ENOG4105CEV competence damage-inducible protein Arth_1457 ENOG4105WBV Transcriptional regulator Arth_1460 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Arth_1461 ENOG4105KC9 Modulates RecA activity (By similarity) Arth_1462 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Arth_1463 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Arth_1464 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Arth_1465 ENOG4107Y49 methyltransferase Arth_1466 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Arth_1468 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Arth_1470 ENOG4105CIH Imidazole acetol-phosphate transaminase Arth_1471 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Arth_1472 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Arth_1473 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Arth_1477 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Arth_1478 ENOG41084BS 50S ribosomal protein L35 Arth_1479 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Arth_1480 ENOG4108RWN rrna methyltransferase Arth_1481 ENOG4105Y3U Transglycosylase-associated protein Arth_1483 ENOG4105F27 Major Facilitator Arth_1486 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) Arth_1487 ENOG4105MPN Membrane Arth_1489 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Arth_1490 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Arth_1494 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Arth_1496 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Arth_1497 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Arth_1498 ENOG4105CAS nag kinase Arth_1499 ENOG4105C8Y Acetylornithine aminotransferase Arth_1500 ENOG4105DBV ornithine carbamoyltransferase Arth_1501 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) Arth_1502 ENOG4105CDH Citrulline--aspartate ligase Arth_1503 ENOG4105CH7 arginosuccinase Arth_1504 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) Arth_1506 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Arth_1508 ENOG4108VX5 3-methyladenine DNA glycosylase Arth_1509 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Arth_1510 ENOG4108KQ5 Integrase catalytic subunit Arth_1512 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Arth_1514 ENOG4105DSU hydrolase Arth_1517 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Arth_1518 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Arth_1519 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Arth_1524 ENOG4105CR4 methylisocitrate lyase Arth_1527 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Arth_1528 ENOG4108MRH transcriptional regulatory protein Arth_1529 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism Arth_1532 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Arth_1533 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Arth_1536 ENOG4105CAT Cytidine monophosphate kinase Arth_1538 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Arth_1541 ENOG4108UW8 fha domain-containing protein Arth_1546 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) Arth_1548 ENOG4105DKQ ROK family Arth_1553 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase Arth_1555 ENOG41068JE domain protein Arth_1557 ENOG4105EAH synthase Arth_1559 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Arth_1561 ENOG4108V6E Cell division protein mraZ Arth_1562 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Arth_1564 ENOG4105CJN penicillin-binding protein Arth_1567 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Arth_1568 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Arth_1569 ENOG4105CNI cell division protein FtsW Arth_1570 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Arth_1571 ENOG4105DFU Cell wall formation (By similarity) Arth_1572 ENOG4105ME9 cell division protein FtsQ Arth_1573 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Arth_1574 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Arth_1576 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) Arth_1578 ENOG4107VQS DivIVA family Arth_1579 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Arth_1585 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Arth_1586 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) Arth_1587 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Arth_1591 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Arth_1592 ENOG4105C5F glutamine synthetase Arth_1593 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) Arth_1594 ENOG4105E89 ABC transporter Arth_1595 ENOG4105E5Q amino acid AbC transporter Arth_1596 ENOG4105CDA abc transporter atp-binding protein Arth_1604 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Arth_1605 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Arth_1608 ENOG4107RE3 peptidase, S41 Arth_1609 ENOG4108Z9K Osmotically inducible protein Arth_1613 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Arth_1617 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Arth_1622 ENOG4105C4M (Ubiquinol oxidase) subunit I Arth_1623 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Arth_1624 ENOG4108JJ9 ABC, transporter Arth_1625 ENOG4108R6G acetyltransferase Arth_1627 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Arth_1628 ENOG410870F Cyclic nucleotide-binding protein Arth_1631 ENOG4107W53 thymidine kinase Arth_1636 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) Arth_1641 ENOG4107VEG TrkA-N domain protein Arth_1642 ENOG4105C0X amino acid Arth_1643 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Arth_1644 ENOG4107QM5 aconitate hydratase Arth_1645 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Arth_1649 ENOG4107SET aldo keto reductase Arth_1653 ENOG4105BZ1 (ABC) transporter Arth_1654 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Arth_1655 ENOG4105CHU acetyl-coa acetyltransferase Arth_1656 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) Arth_1661 ENOG4105E0X reductase Arth_1664 ENOG4108Z66 YbaK ebsC protein Arth_1670 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Arth_1671 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Arth_1673 ENOG4105DJV ribulose-phosphate 3-epimerase Arth_1676 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Arth_1677 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Arth_1678 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Arth_1679 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase Arth_1680 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Arth_1681 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Arth_1683 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Arth_1687 ENOG4105DK0 Indole-3-glycerol phosphate synthase Arth_1688 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Arth_1689 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Arth_1690 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Arth_1691 ENOG4105CBC glutamate synthase Arth_1698 ENOG4106AM8 polysaccharide lyase family 8 Arth_1699 ENOG4105CMD Transcriptional regulator, GntR family Arth_1700 ENOG4105CBG Sulfatase Arth_1701 ENOG4105CBG Sulfatase Arth_1702 ENOG4106N3A copper homeostasis protein cutc Arth_1708 ENOG4106KS4 Sulfatase Arth_1709 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Arth_1710 ENOG4105DKQ ROK family Arth_1713 ENOG4105CE4 GlcNAc 6-P deacetylase Arth_1714 ENOG4105E6M Sulphatase-modifying factor protein Arth_1715 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) Arth_1716 ENOG4105CBG Sulfatase Arth_1722 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Arth_1723 ENOG4105C26 Dehydrogenase Arth_1727 ENOG4105Q56 cytochrome P450 Arth_1730 ENOG4105MSY salicylate hydroxylase Arth_1733 ENOG4105EXU Membrane Arth_1735 ENOG4107RY6 amino acid Arth_1739 ENOG41060H3 Protein of unknown function (DUF1049) Arth_1742 ENOG4108YV4 Universal stress protein Arth_1744 ENOG4105DCF alanine dehydrogenase Arth_1753 ENOG4105CSH Transporter Arth_1754 ENOG4105DV0 amidase (EC 3.5.1.4 Arth_1756 ENOG4105CQB FAD linked oxidase domain protein Arth_1757 ENOG4108JPW Aminotransferase Arth_1758 ENOG4105F9U Dehydrogenase Arth_1759 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Arth_1760 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) Arth_1762 ENOG4107S4Y M20 DapE family protein YgeY Arth_1763 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Arth_1764 ENOG4105ENR peptidase, M24 Arth_1771 ENOG4105BZU Histidine kinase Arth_1773 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Arth_1775 ENOG4105BZU Histidine kinase Arth_1777 ENOG4105VUF Transcriptional regulator Arth_1781 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Arth_1783 ENOG4105BZU Histidine kinase Arth_1784 ENOG4105D1K glutamate--cysteine ligase Arth_1787 ENOG4105CHR reductase Arth_1788 ENOG4105CSH Transporter Arth_1789 ENOG4105CPQ Dehydrogenase Arth_1791 ENOG4105DE4 1-phosphofructokinase Arth_1793 ENOG4108HHA Transketolase Arth_1794 ENOG4105CPQ Dehydrogenase Arth_1795 ENOG4107258 Transcriptional regulator Arth_1798 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 Arth_1799 ENOG4106KNT transcriptional regulator Arth_1800 ENOG4108JQ1 Dehydrogenase Arth_1801 ENOG4108Y83 glucose-6-phosphate isomerase Arth_1803 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Arth_1804 ENOG4105CPQ Dehydrogenase Arth_1805 ENOG4105CPQ Dehydrogenase Arth_1806 ENOG4108R85 Short chain dehydrogenase Arth_1807 ENOG4108UHU Aldolase Arth_1809 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Arth_1811 ENOG4105C2J ABC transporter Arth_1812 ENOG4105CNN ABC, transporter Arth_1813 ENOG4105EWI Short-chain dehydrogenase reductase Sdr Arth_1814 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Arth_1815 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Arth_1816 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) Arth_1817 ENOG4105F27 Major Facilitator Arth_1819 ENOG4105H9W Short-chain dehydrogenase reductase Sdr Arth_1821 ENOG4105CPQ Dehydrogenase Arth_1823 ENOG4105CPQ Dehydrogenase Arth_1824 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Arth_1825 ENOG4105C2J ABC transporter Arth_1826 ENOG4105CNN ABC, transporter Arth_1828 ENOG4105BZP glycoside hydrolase 15-related Arth_1830 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) Arth_1831 ENOG4107R7Y intracellular protease Pfpi family Arth_1835 ENOG41060NJ transcriptional regulator Arth_1839 ENOG4107QK4 glycoside hydrolase, family 3 domain protein Arth_1852 ENOG41090KN UPF0303 protein Arth_1853 ENOG4105ETE Transcriptional regulator (LacI family Arth_1854 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Arth_1855 ENOG4105EP8 Glycosyl Hydrolase Family 88 Arth_1856 ENOG4105C26 Dehydrogenase Arth_1857 ENOG4105E39 Enoyl-CoA hydratase Arth_1859 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) Arth_1864 ENOG4105DRS transport system, permease Arth_1866 ENOG4108RTU Aldolase Arth_1867 ENOG4106F1P AAA ATPase, central domain protein Arth_1870 ENOG4105CKW Inner membrane protein yedI Arth_1875 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Arth_1876 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Arth_1877 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) Arth_1890 ENOG4105CID antiterminator Arth_1891 ENOG4105CS2 ec 3.2.1.21 Arth_1892 ENOG4105C5Y PTS System Arth_1893 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) Arth_1895 ENOG4105D2S major facilitator superfamily Arth_1896 ENOG4105FP9 thiamine pyrophosphate Arth_1899 ENOG4105EMF GntR family transcriptional regulator Arth_1901 ENOG4105CXK mandelate racemase muconate lactonizing Arth_1904 ENOG4105C0H protease Arth_1906 ENOG4105BZU Histidine kinase Arth_1912 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) Arth_1914 ENOG4105CNN ABC, transporter Arth_1915 ENOG4105C2J ABC transporter Arth_1918 ENOG4105ETE Transcriptional regulator (LacI family Arth_1919 ENOG4105DFW ABC transporter Arth_1921 ENOG4105CNN ABC, transporter Arth_1925 ENOG4105ETE Transcriptional regulator (LacI family Arth_1930 ENOG4107RSM transcriptional regulator Arth_1931 ENOG4105DTQ mandelate racemase muconate lactonizing Arth_1932 ENOG4105NN7 muconolactone delta-isomerase Arth_1933 ENOG4108QMY dioxygenase Arth_1934 ENOG4105MXW flavin reductase domain protein, FMN-binding Arth_1936 ENOG4107RQ0 Maleylacetate reductase Arth_1937 ENOG4105D0M Protease HtpX homolog Arth_1942 ENOG4107QKS N-acylglucosamine 2-epimerase Arth_1944 ENOG4105C26 Dehydrogenase Arth_1945 ENOG4105I1K ABC transporter Arth_1946 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component Arth_1948 ENOG4105D2M Aldolase Arth_1950 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Arth_1951 ENOG4105E98 transcriptional regulator DeoR family Arth_1952 ENOG4107QKV phosphomannomutase Arth_1957 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Arth_1959 ENOG4105C0R drug resistance transporter emrb qaca subfamily Arth_1965 ENOG4108IMY Transcriptional regulator Arth_1966 ENOG4105C3M thioredoxin reductase Arth_1967 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Arth_1972 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Arth_1978 ENOG4106A3M Cytochrome p-450 Arth_1979 ENOG4105MWK D-amino acid dehydrogenase, small subunit Arth_1980 ENOG4105D9R oxidoreductase Arth_1981 ENOG4105CDA abc transporter atp-binding protein Arth_1982 ENOG4105EAD ABC transporter Arth_1983 ENOG4106PMH Extracellular solute-binding protein family 3 Arth_1984 ENOG4105ETE Transcriptional regulator (LacI family Arth_1985 ENOG4105BZU Histidine kinase Arth_1987 ENOG4107KWJ von Willebrand factor, type A Arth_1991 ENOG4105I4A GCN5-related N-acetyltransferase Arth_1992 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Arth_1993 ENOG4107HP6 Transcriptional regulator Arth_1997 ENOG4105CHR reductase Arth_2002 ENOG4105EXC Acyl-transferase Arth_2004 ENOG4105HFS 5'-3' exonuclease Arth_2007 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Arth_2009 ENOG4108JQ1 Dehydrogenase Arth_2013 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Arth_2015 ENOG4105C6F GntR Family Transcriptional Regulator Arth_2017 ENOG4105ECR NmrA family Arth_2019 ENOG4105C7F AcnD-accessory protein PrpF Arth_2026 ENOG4105CQ7 ATP-dependent helicase Arth_2030 ENOG4107QW3 Sucrose phosphorylase Arth_2032 ENOG4107RTD sua5 ycio yrdc ywlc family protein Arth_2038 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family Arth_2045 ENOG4105WH1 Two component transcriptional regulator luxr family Arth_2046 ENOG4105CY0 Metallo-Beta-Lactamase Arth_2051 ENOG4105ERH Fumarylacetoacetate hydrolase Arth_2054 ENOG4105D2S major facilitator superfamily Arth_2062 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) Arth_2064 ENOG4105HHS UPF0256 protein Arth_2065 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Arth_2068 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Arth_2069 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Arth_2070 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Arth_2075 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) Arth_2076 ENOG4105BZ1 (ABC) transporter Arth_2078 ENOG4105FDP GntR family transcriptional regulator Arth_2079 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Arth_2080 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Arth_2082 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Arth_2083 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) Arth_2084 ENOG4105CHW UPF0052 protein Arth_2085 ENOG4105CIE May be required for sporulation (By similarity) Arth_2086 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Arth_2087 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Arth_2088 ENOG4105BZA Phosphoglycerate kinase Arth_2089 ENOG4105CP7 Triose-phosphate isomerase Arth_2092 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) Arth_2095 ENOG4105C89 phosphohexose isomerase Arth_2096 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Arth_2098 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Arth_2099 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) Arth_2101 ENOG4105CJ1 ABC, transporter Arth_2106 ENOG4105C3K feS assembly ATPase SufC Arth_2107 ENOG4105VG1 fes assembly suf system protein Arth_2109 ENOG4105CEY Amp-dependent synthetase and ligase Arth_2112 ENOG4108JJB ABC transporter Arth_2113 ENOG4107ZYJ bioY protein Arth_2114 ENOG4105C5H ABC transporter Arth_2115 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Arth_2119 ENOG4105CHR reductase Arth_2122 ENOG4105H9W Short-chain dehydrogenase reductase Sdr Arth_2123 ENOG4105EAC phosphoserine phosphatase Arth_2124 ENOG4105DKW ABC transporter Arth_2127 ENOG4105NRA 50s ribosomal protein l31 type b Arth_2130 ENOG4107ZR7 Membrane Arth_2140 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) Arth_2141 ENOG4107QPH glycogen) synthase Arth_2144 ENOG4105CHU acetyl-coa acetyltransferase Arth_2145 ENOG4105CHR reductase Arth_2149 ENOG4105CHF Glutathione S-transferase Arth_2156 ENOG4105D5U fad dependent oxidoreductase Arth_2157 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Arth_2162 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Arth_2166 ENOG4105CV8 reductase Arth_2167 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Arth_2168 ENOG4105C8N cysteinyl-tRNA synthetase Arth_2170 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 Arth_2173 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) Arth_2174 ENOG4105E5F proteasome Arth_2175 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) Arth_2176 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) Arth_2177 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) Arth_2178 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) Arth_2179 ENOG4108V1T peptidylprolyl cis-trans isomerase Arth_2184 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Arth_2185 ENOG4105CQR helicase Arth_2186 ENOG4105EFZ amidohydrolase Arth_2187 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) Arth_2192 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein Arth_2193 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Arth_2196 ENOG4107SCK Monooxygenase Arth_2199 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Arth_2200 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Arth_2208 ENOG4108I0Q anthranilate phosphoribosyltransferase Arth_2209 ENOG4105CCU oxidase (Subunit III) Arth_2210 ENOG4107UDY cytochrome C Arth_2211 ENOG4107EUI c reductase, iron-sulfur Arth_2212 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Arth_2214 ENOG410849S phosphocarrier protein (HPr) Arth_2215 ENOG4108ZRS Part of cytochrome c oxidase, its function is Arth_2216 ENOG4105BZ9 Cytochrome C oxidase, subunit I Arth_2217 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) Arth_2219 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Arth_2221 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Arth_2224 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Arth_2225 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) Arth_2226 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Arth_2227 ENOG4105C9K Endothelin-converting enzyme 1 Arth_2228 ENOG4107TB5 TRANSCRIPTIONal Arth_2229 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Arth_2231 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Arth_2234 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Arth_2235 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Arth_2236 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) Arth_2239 ENOG4105CSA Coproporphyrinogen iii oxidase Arth_2240 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Arth_2242 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) Arth_2245 ENOG4105BZM domain protein Arth_2246 ENOG4105EPR degv family Arth_2247 ENOG4105C8T Leucyl-tRNA synthetase Arth_2248 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Arth_2249 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Arth_2252 ENOG4105CV8 reductase Arth_2254 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Arth_2256 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Arth_2258 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) Arth_2259 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Arth_2260 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Arth_2261 ENOG4105SKN orotidine 5''-phosphate decarboxylase Arth_2262 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Arth_2263 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Arth_2265 ENOG4105CD3 dihydroorotase Arth_2266 ENOG4105CXT aspartate transcarbamylase Arth_2267 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) Arth_2269 ENOG410803B Involved in the transcription termination process (By similarity) Arth_2270 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Arth_2272 ENOG4105D49 3-dehydroquinate synthase Arth_2274 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Arth_2275 ENOG4105E2X shikimate dehydrogenase Arth_2277 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Arth_2278 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Arth_2281 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Arth_2285 ENOG4107HP6 Transcriptional regulator Arth_2287 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein Arth_2289 ENOG4105CSH Transporter Arth_2291 ENOG4105C9M aspartyl-trna synthetase Arth_2293 ENOG4105CUT histidyl-tRNA synthetase Arth_2295 ENOG4105C99 atpase involved in dna repair Arth_2297 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Arth_2298 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Arth_2299 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Arth_2301 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Arth_2302 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Arth_2303 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Arth_2304 ENOG4105CDY transcriptional regulatory protein Arth_2305 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) Arth_2306 ENOG4105DMS mur ligase Arth_2313 ENOG4105DGW oligopeptidase A Arth_2314 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) Arth_2315 ENOG4108VTU Cdp-alcohol phosphatidyltransferase Arth_2317 ENOG4105C22 threonyL-tRNA synthetase Arth_2318 ENOG4105C0B DNA polymerase III (alpha subunit) Arth_2323 ENOG4108RAV Conserved protein Arth_2340 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Arth_2343 ENOG4105CDA abc transporter atp-binding protein Arth_2344 ENOG4105DRP amino acid AbC transporter Arth_2352 ENOG4105H9W Short-chain dehydrogenase reductase Sdr Arth_2355 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Arth_2356 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Arth_2357 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) Arth_2359 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Arth_2360 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Arth_2364 ENOG4105C26 Dehydrogenase Arth_2366 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) Arth_2374 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Arth_2378 ENOG4105BZ7 extracellular solute-binding protein family 1 Arth_2379 ENOG4105E2R ROK family Arth_2380 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) Arth_2381 ENOG4105CAY ferredoxin--nadp reductase Arth_2382 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA Arth_2385 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Arth_2387 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Arth_2388 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Arth_2389 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Arth_2390 ENOG4105K46 50S ribosomal protein l27 Arth_2391 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Arth_2392 ENOG4105DWF phosphomethylpyrimidine kinase Arth_2393 ENOG4105C03 ribonuclease Arth_2395 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Arth_2397 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Arth_2398 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Arth_2401 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Arth_2402 ENOG4105MC2 DSBA oxidoreductase Arth_2403 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Arth_2404 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Arth_2405 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Arth_2406 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Arth_2413 ENOG4105D8X mechanosensitive ion channel Arth_2417 ENOG4105C29 acyl-CoA thioesterase Arth_2421 ENOG41060H3 Protein of unknown function (DUF1049) Arth_2426 ENOG4105ETE Transcriptional regulator (LacI family Arth_2429 ENOG4105DKQ ROK family Arth_2430 ENOG4105C93 Xylose Isomerase Arth_2432 ENOG4107WI4 Aldose-1-epimerase Arth_2434 ENOG4107JC6 Membrane Arth_2435 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) Arth_2436 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Arth_2442 ENOG4107XFJ UPF0246 protein Arth_2444 ENOG4105EGD dinuclear metal center protein, YbgI family Arth_2445 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) Arth_2447 ENOG4105D7W serine acetyltransferase Arth_2448 ENOG4105E1F short-chain dehydrogenase reductase Arth_2449 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Arth_2451 ENOG4105CPQ Dehydrogenase Arth_2452 ENOG4105CHR reductase Arth_2454 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase Arth_2464 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) Arth_2467 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Arth_2468 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Arth_2471 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Arth_2473 ENOG4105C0P Mg chelatase subunit ChlI Arth_2474 ENOG41080R2 UPF0102 protein Arth_2476 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Arth_2478 ENOG4107QYR Signal peptidase i Arth_2479 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Arth_2480 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Arth_2481 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Arth_2482 ENOG41082KU UPF0109 protein Arth_2483 ENOG4105K5M 30s ribosomal protein S16 Arth_2485 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase Arth_2493 ENOG4105C57 major facilitator superfamily Arth_2500 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Arth_2501 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Arth_2502 ENOG41062IY 50S ribosomal protein L32 Arth_2504 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Arth_2509 ENOG4106H78 methyltransferase Arth_2514 ENOG4105CPF Cell wall formation (By similarity) Arth_2515 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Arth_2517 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Arth_2518 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Arth_2519 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Arth_2520 ENOG41069M3 Transcriptional regulator Arth_2526 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Arth_2527 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase Arth_2529 ENOG4105CM2 brancheD-chain amino acid aminotransferase Arth_2530 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Arth_2534 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Arth_2536 ENOG4108JQ1 Dehydrogenase Arth_2537 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Arth_2538 ENOG4108ZP8 Acetolactate synthase small subunit Arth_2540 ENOG4105C01 Dihydroxy-acid dehydratase Arth_2541 ENOG4105C5Q Transcriptional regulator Arth_2542 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Arth_2543 ENOG4105D8V Glucose sorbosone dehydrogenase Arth_2548 ENOG4105DEF Extracellular solute-binding protein, family 5 Arth_2549 ENOG4105DWT malate dehydrogenase (quinone) Arth_2551 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone Arth_2552 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes Arth_2555 ENOG4105ERH Fumarylacetoacetate hydrolase Arth_2557 ENOG4107QI6 Cysteine desulfurase Arth_2558 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Arth_2559 ENOG4108IYU L-aspartate oxidase Arth_2560 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) Arth_2563 ENOG4105C85 amino acid Arth_2565 ENOG4105CPP Dehydrogenase, E1 component Arth_2566 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 Arth_2567 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 Arth_2568 ENOG4105CSH Transporter Arth_2571 ENOG41069M3 Transcriptional regulator Arth_2573 ENOG4105EYH Exonuclease Arth_2575 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Arth_2578 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Arth_2579 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN Arth_2580 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Arth_2581 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) Arth_2582 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Arth_2583 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Arth_2585 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) Arth_2587 ENOG4108RWI nicotinamidase Arth_2590 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) Arth_2593 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Arth_2599 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) Arth_2601 ENOG4105FF5 Membrane Arth_2604 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Arth_2605 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Arth_2606 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Arth_2607 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Arth_2608 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Arth_2609 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) Arth_2610 ENOG4106DE0 ATP synthase Arth_2611 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) Arth_2614 ENOG4105ESV Glycosyl transferase, family 4 Arth_2617 ENOG4107UIY sua5 ycio yrdc ywlc family protein Arth_2618 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Arth_2619 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Arth_2621 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) Arth_2622 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) Arth_2623 ENOG4105D6E homoserine dehydrogenase Arth_2624 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Arth_2625 ENOG4105C75 arginyL-tRNA synthetase Arth_2628 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) Arth_2629 ENOG4105D4Y metalloprotease Arth_2632 ENOG4105CQ7 ATP-dependent helicase Arth_2633 ENOG4107ZUX Histidine triad (HIT) protein Arth_2634 ENOG4105DQ4 alcohol dehydrogenase Arth_2635 ENOG4105KHC sulfurtransferase Arth_2640 ENOG4105DIK (ABC) transporter Arth_2643 ENOG4105C37 (CBS) domain Arth_2645 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 Arth_2651 ENOG4105EMN RNA polymerase sigma factor Arth_2653 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Arth_2655 ENOG4107TK4 histidinol-phosphate phosphatase Arth_2656 ENOG4105C9B Cysteine desulfurase Arth_2659 ENOG41085J0 Protein CrcB homolog Arth_2660 ENOG410814D Protein CrcB homolog Arth_2662 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Arth_2663 ENOG41061JJ Peptidase family M23 Arth_2665 ENOG4105CAK Cell division ATP-binding protein ftsE Arth_2666 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) Arth_2679 ENOG4105C1B dTDP-glucose 4-6-dehydratase Arth_2681 ENOG410838F Glycosyl transferase family 2 Arth_2687 ENOG4105EXC Acyl-transferase Arth_2688 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) Arth_2690 ENOG4105EXC Acyl-transferase Arth_2691 ENOG4105EY8 ABC transporter Arth_2693 ENOG410602S Transferase Arth_2699 ENOG4105C7I Dehydrogenase Arth_2706 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Arth_2707 ENOG4105T0Z Conserved Protein Arth_2708 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea Arth_2710 ENOG4108T3R lipoprotein lpqB Arth_2711 ENOG4105BZU Histidine kinase Arth_2715 ENOG4108WQ6 secreted protein Arth_2716 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Arth_2721 ENOG4108JQ6 ABC transporter Arth_2722 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Arth_2723 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Arth_2727 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Arth_2730 ENOG4105FDR Membrane Arth_2734 ENOG4105CBD Diacylglycerol kinase Arth_2735 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Arth_2736 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Arth_2741 ENOG4105C10 Electron transfer flavoprotein Arth_2742 ENOG4105BZJ Electron transfer flavoprotein Arth_2743 ENOG4105C0H protease Arth_2745 ENOG41087YS Phage shock protein A Arth_2747 ENOG4105CVP deoxyribo-dipyrimidine photolyase Arth_2749 ENOG4105DJZ UPF0182 protein Arth_2750 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Arth_2754 ENOG4105E09 nadh pyrophosphatase Arth_2760 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Arth_2761 ENOG4108UMI ABC transporter, permease Arth_2762 ENOG4105D01 (LipO)protein Arth_2763 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Arth_2765 ENOG4105D52 delta-aminolevulinic acid dehydratase Arth_2767 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Arth_2768 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Arth_2769 ENOG4107JTW chlorite dismutase Arth_2772 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Arth_2773 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Arth_2778 ENOG4105KZX Pterin carbinolamine dehydratase Arth_2779 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Arth_2781 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Arth_2782 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Arth_2784 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Arth_2785 ENOG4105C1J atp-dependent rna helicase Arth_2786 ENOG4105CEC DNA methylase N-4 N-6 Arth_2788 ENOG4107T6F Xaa-Pro aminopeptidase Arth_2790 ENOG4105CJW magnesium transporter Arth_2793 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) Arth_2795 ENOG4105DU6 RNA polymerase Arth_2800 ENOG4108URH decarboxylase Arth_2801 ENOG4105CDA abc transporter atp-binding protein Arth_2802 ENOG4107UBR Extracellular solute-binding protein family 3 Arth_2803 ENOG4105EAD ABC transporter Arth_2804 ENOG4105DRP amino acid AbC transporter Arth_2805 ENOG4107R4C succinyl-diaminopimelate desuccinylase Arth_2806 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) Arth_2809 ENOG4105W1N transcriptional regulator Arth_2810 ENOG4105CMR udp-glucose 4-epimerase Arth_2813 ENOG4108Z4U Ferredoxin Arth_2817 ENOG4105CI3 gtp-binding protein typa Arth_2819 ENOG4108JQ6 ABC transporter Arth_2820 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Arth_2821 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Arth_2822 ENOG4108EVY peptide transport periplasmic protein Arth_2823 ENOG4108JQ6 ABC transporter Arth_2826 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Arth_2827 ENOG4108J59 Extracellular solute-binding protein, family 5 Arth_2831 ENOG4105C3G gtp-binding protein Arth_2832 ENOG4105CGY Dna recombination protein Arth_2833 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Arth_2835 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Arth_2836 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Arth_2837 ENOG4105CSR polyphosphate kinase 2 Arth_2840 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component Arth_2841 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component Arth_2842 ENOG4108IJ8 ABC transporter Arth_2843 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Arth_2844 ENOG4105EUB pirin domain protein Arth_2845 ENOG4105RD7 BadF BadG BcrA BcrD Arth_2847 ENOG4105C5Q Transcriptional regulator Arth_2848 ENOG4105D94 Major Facilitator Superfamily Arth_2855 ENOG4105D7N magnesium and cobalt transport protein CorA Arth_2860 ENOG4105C5H ABC transporter Arth_2861 ENOG4105ECP epimerase Arth_2864 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Arth_2865 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase Arth_2869 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Arth_2873 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Arth_2874 ENOG4107QVP Dehydrogenase Arth_2875 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Arth_2876 ENOG4105BZ1 (ABC) transporter Arth_2879 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Arth_2880 ENOG4105EXC Acyl-transferase Arth_2883 ENOG4105H3G oxidoreductase Arth_2886 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Arth_2887 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Arth_2889 ENOG4105F9E Shikimate 5-dehydrogenase Arth_2890 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) Arth_2891 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) Arth_2892 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Arth_2895 ENOG4108097 ATP-binding protein Arth_2896 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Arth_2897 ENOG4105DE4 1-phosphofructokinase Arth_2900 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Arth_2901 ENOG4105CKU formyltetrahydrofolate synthetase Arth_2906 ENOG4105CPC Aldo Keto reductase Arth_2911 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Arth_2912 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Arth_2913 ENOG4105CS9 pantothenic acid kinase Arth_2915 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) Arth_2916 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Arth_2917 ENOG4108UJD 30S ribosomal protein S9 Arth_2918 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Arth_2932 ENOG4107QMS site-determining protein Arth_2937 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Arth_2938 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Arth_2939 ENOG4108ZT0 50S ribosomal protein l17 Arth_2940 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Arth_2941 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Arth_2942 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Arth_2943 ENOG41067V7 50S ribosomal protein L36 Arth_2944 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Arth_2945 ENOG4105KXX peptidase s58 dmpa Arth_2947 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component Arth_2948 ENOG4105BZ7 extracellular solute-binding protein family 1 Arth_2951 ENOG4105CEY Amp-dependent synthetase and ligase Arth_2952 ENOG4106A3M Cytochrome p-450 Arth_2954 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Arth_2955 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Arth_2958 ENOG410849U 50S ribosomal protein L30 Arth_2959 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Arth_2960 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Arth_2961 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Arth_2962 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Arth_2963 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Arth_2964 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Arth_2965 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Arth_2966 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Arth_2967 ENOG41082SA 50s ribosomal protein l29 Arth_2968 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Arth_2969 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Arth_2970 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Arth_2971 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Arth_2972 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Arth_2973 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Arth_2974 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Arth_2975 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Arth_2976 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Arth_2979 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Arth_2980 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Arth_2981 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Arth_2982 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Arth_2983 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Arth_2984 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Arth_2986 ENOG4105CHU acetyl-coa acetyltransferase Arth_2987 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Arth_2988 ENOG4105CGH 5'-nucleotidase Arth_2989 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Arth_2990 ENOG4108VZM 50s ribosomal protein L10 Arth_2993 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) Arth_2994 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Arth_2996 ENOG410683Z Preprotein translocase SecE subunit Arth_2998 ENOG4105WH1 Two component transcriptional regulator luxr family Arth_3008 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Arth_3010 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands Arth_3012 ENOG4107NHD transcriptional regulator Arth_3013 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) Arth_3014 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) Arth_3018 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) Arth_3021 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Arth_3024 ENOG4107R4N Cell wall formation (By similarity) Arth_3025 ENOG4106UW1 Major Facilitator superfamily Arth_3027 ENOG410900P UPF0336 protein Arth_3029 ENOG4105CHH sulfate transporter Arth_3035 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Arth_3037 ENOG4107QM2 Aldo Keto reductase Arth_3038 ENOG4105CG3 alpha amylase, catalytic region Arth_3039 ENOG4105I1K ABC transporter Arth_3042 ENOG4105DKQ ROK family Arth_3046 ENOG4105K6V RNA polymerase Arth_3047 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Arth_3053 ENOG4106032 Glutathionylspermidine synthase Arth_3054 ENOG4105D5Q Arginine ornithine antiporter Arth_3055 ENOG4105C1G acyl-Coa dehydrogenase Arth_3056 ENOG4107EXU Short-chain dehydrogenase reductase Sdr Arth_3057 ENOG4108VJY integral membrane protein Arth_3059 ENOG4107YPT transcriptional regulator Arth_3060 ENOG4108U8T Mannosyltransferase Arth_3066 ENOG4105CEY Amp-dependent synthetase and ligase Arth_3068 ENOG41080RH Thioredoxin Arth_3073 ENOG4108VPT UPF0234 protein Arth_3074 ENOG4105D0M Protease HtpX homolog Arth_3075 ENOG4105E8G Major facilitator Superfamily Arth_3078 ENOG4105CH6 catalase Arth_3081 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Arth_3083 ENOG4105D2X ABC transporter substrate-binding protein Arth_3085 ENOG4105CUB amino acid Arth_3088 ENOG4105C26 Dehydrogenase Arth_3089 ENOG4107RR1 TRANSCRIPTIONal Arth_3095 ENOG4105C26 Dehydrogenase Arth_3096 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR Arth_3098 ENOG4105CEY Amp-dependent synthetase and ligase Arth_3098 ENOG4105CEY Amp-dependent synthetase and ligase Arth_3104 ENOG4105JXH GntR family transcriptional regulator Arth_3116 ENOG4108IY8 ABC, transporter Arth_3118 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Arth_3119 ENOG4105E0Y RtcB Protein Arth_3124 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) Arth_3125 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) Arth_3127 ENOG4105EN6 Membrane Arth_3132 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Arth_3133 ENOG4105E4F Isochorismate synthase Arth_3134 ENOG4107R0W ABC transporter Arth_3135 ENOG4105DRP amino acid AbC transporter Arth_3138 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) Arth_3139 ENOG4105ETE Transcriptional regulator (LacI family Arth_3140 ENOG4108HKT sucrose-6-phosphate hydrolase Arth_3141 ENOG4105DRS transport system, permease Arth_3142 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Arth_3144 ENOG4105ETE Transcriptional regulator (LacI family Arth_3147 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Arth_3148 ENOG4105DRS transport system, permease Arth_3151 ENOG4105C75 arginyL-tRNA synthetase Arth_3153 ENOG4107TCW O-succinylbenzoate synthase Arth_3157 ENOG4105CHM Aminotransferase Arth_3161 ENOG4105H3G oxidoreductase Arth_3184 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Arth_3189 ENOG4105EXC Acyl-transferase Arth_3190 ENOG4105EXC Acyl-transferase Arth_3191 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 Arth_3192 ENOG4105CPP Dehydrogenase, E1 component Arth_3194 ENOG4105EW9 transcriptional regulator AsnC family Arth_3195 ENOG4108QV3 biosynthesis protein Arth_3203 ENOG4108SHN Glycosyl transferase, family 2 Arth_3205 ENOG4105E2K Glycosyl transferase (Group 1 Arth_3207 ENOG4105C6Y Udp-glucose 6-dehydrogenase Arth_3211 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Arth_3213 ENOG4105CGU Enoyl-CoA hydratase Arth_3214 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) Arth_3215 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit Arth_3216 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit Arth_3217 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit Arth_3218 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit Arth_3221 ENOG4107YJ4 chain length determinant protein Arth_3227 ENOG4107ZF2 Phosphatase Arth_3228 ENOG4108KGH TRANSCRIPTIONal Arth_3238 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Arth_3240 ENOG4105C6K Malic enzyme Arth_3242 ENOG4105C2C drug resistance transporter, Bcr CflA Arth_3246 ENOG4108ZJI phenylacetic acid degradation protein Arth_3254 ENOG4108638 50S ribosomal protein L36 Arth_3255 ENOG4105DXM phenylacetic acid degradation protein Arth_3256 ENOG4105KA0 thioesterase Superfamily protein Arth_3258 ENOG4107YEV ferritin Arth_3259 ENOG4105DU6 RNA polymerase Arth_3266 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Arth_3267 ENOG4105E39 Enoyl-CoA hydratase Arth_3268 ENOG4105CHU acetyl-coa acetyltransferase Arth_3273 ENOG4105C85 amino acid Arth_3274 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit Arth_3275 ENOG4108IFG nitrite reductase, (NAD(P)H) Arth_3279 ENOG4105DIK (ABC) transporter Arth_3281 ENOG4108TYN CAAX amino terminal protease family protein Arth_3283 ENOG4107SIQ Naphthoate synthase Arth_3289 ENOG4105CRE cytochrome C Arth_3291 ENOG4107QIV Cytochrome c biogenesis protein Arth_3293 ENOG4108RH7 phosphoglycerate mutase Arth_3294 ENOG4108YYC ycei family Arth_3297 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) Arth_3299 ENOG4108RXW HAD-superfamily subfamily IB hydrolase Arth_3302 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) Arth_3303 ENOG4105I82 acetyl xylan esterase Arth_3304 ENOG4105DET Rhamnulokinase Arth_3307 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) Arth_3308 ENOG4105ETE Transcriptional regulator (LacI family Arth_3310 ENOG4105CHR reductase Arth_3311 ENOG4105CPC Aldo Keto reductase Arth_3313 ENOG4107TDE lipolytic protein G-D-S-L family Arth_3314 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Arth_3316 ENOG4105E0S extracellular solute-binding protein family 1 Arth_3317 ENOG4105MU9 integral membrane protein Arth_3320 ENOG4107Y80 Major Facilitator superfamily Arth_3322 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Arth_3323 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Arth_3327 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Arth_3328 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Arth_3333 ENOG4105CHH sulfate transporter Arth_3336 ENOG4105DIA mandelate racemase muconate lactonizing Arth_3339 ENOG4105DDC Oxidoreductase domain protein Arth_3340 ENOG4105ETE Transcriptional regulator (LacI family Arth_3344 ENOG41082BM Transcriptional regulator, arsr family Arth_3345 ENOG4105DGU Histone deacetylase Arth_3346 ENOG4105CZN Potassium uptake protein Arth_3348 ENOG4105II7 pyrroline-5-carboxylate reductase Arth_3349 ENOG4105CHP RNA polymerase Arth_3351 ENOG4105EY0 Xylose isomerase domain protein TIM barrel Arth_3352 ENOG4107R33 ppx gppa phosphatase Arth_3355 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Arth_3358 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Arth_3360 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Arth_3365 ENOG4105C72 UPF0176 protein Arth_3367 ENOG4108I5C dEAD DEAH box helicase Arth_3374 ENOG4105C2M dna polymerase I Arth_3375 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Arth_3376 ENOG4105CSM endonuclease III Arth_3378 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Arth_3381 ENOG4105I1K ABC transporter Arth_3382 ENOG4105MVE transcriptional regulator Arth_3383 ENOG4105ETE Transcriptional regulator (LacI family Arth_3386 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Arth_3392 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Arth_3399 ENOG4105BZ4 penicillin-binding protein Arth_3400 ENOG4107RGJ metallophosphoesterase Arth_3401 ENOG4105BZ1 (ABC) transporter Arth_3402 ENOG4105BZ1 (ABC) transporter Arth_3403 ENOG4105BZ1 (ABC) transporter Arth_3405 ENOG4105C8V SAICAR synthetase Arth_3406 ENOG4105C12 Phosphoribosylglycinamide synthetase Arth_3410 ENOG4105CK2 sodium dicarboxylate symporter Arth_3412 ENOG410633P Hydantoin racemase Arth_3413 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease Arth_3414 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) Arth_3419 ENOG4105CPC Aldo Keto reductase Arth_3420 ENOG4105C7W Xanthine dehydrogenase Arth_3422 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family Arth_3423 ENOG4105C7N Xanthine uracil vitamin C permease Arth_3424 ENOG4107Y2X deaminase Arth_3425 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Arth_3426 ENOG4105DQE DNA ligase Arth_3428 ENOG4105C2W permease Arth_3430 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease Arth_3431 ENOG41069M3 Transcriptional regulator Arth_3433 ENOG4107R9S Malate synthase Arth_3435 ENOG4105S0E allantoin catabolism protein Arth_3439 ENOG4107VXZ Hydrolase Arth_3441 ENOG4105ERH Fumarylacetoacetate hydrolase Arth_3442 ENOG4105BZP glycoside hydrolase 15-related Arth_3447 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Arth_3449 ENOG4107X2D transcriptional regulator, merr family Arth_3451 ENOG4105F1N DNA alkylation repair Arth_3453 ENOG4105CPC Aldo Keto reductase Arth_3454 ENOG4105E9Z Nad-dependent epimerase dehydratase Arth_3457 ENOG4108YV4 Universal stress protein Arth_3461 ENOG4105E2K Glycosyl transferase (Group 1 Arth_3465 ENOG4107FKK extracellular solute-binding protein family 1 Arth_3467 ENOG4105I1K ABC transporter Arth_3471 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Arth_3472 ENOG41067RQ csbd family Arth_3473 ENOG4108IUX (ABC) transporter Arth_3480 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein Arth_3482 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Arth_3484 ENOG4105CSH Transporter Arth_3488 ENOG4108Z0Z intracellular protease Pfpi family Arth_3490 ENOG4105WH1 Two component transcriptional regulator luxr family Arth_3491 ENOG4105ENE Histidine kinase Arth_3492 ENOG4105E3W Two component transcriptional regulator (Winged helix family Arth_3493 ENOG4106WF9 DNA-binding transcriptional regulator TorR Arth_3496 ENOG4105C7B Threonine dehydratase Arth_3497 ENOG4107HP6 Transcriptional regulator Arth_3498 ENOG4105E2X shikimate dehydrogenase Arth_3499 ENOG4105CSH Transporter Arth_3503 ENOG4105W1N transcriptional regulator Arth_3504 ENOG41063TF transcriptional regulator (AraC Arth_3505 ENOG4105D82 Glutamate dehydrogenase Arth_3506 ENOG4105IW1 AmiS UreI transporter Arth_3511 ENOG4105C26 Dehydrogenase Arth_3512 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) Arth_3513 ENOG4105CE4 GlcNAc 6-P deacetylase Arth_3514 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane Arth_3516 ENOG4105C5Y PTS System Arth_3517 ENOG4105FDP GntR family transcriptional regulator Arth_3519 ENOG4105QPS Monooxygenase Arth_3521 ENOG4108WYP Transcriptional regulator Arth_3526 ENOG4105BZ4 penicillin-binding protein Arth_3528 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family Arth_3529 ENOG4105C6Z Gluconate Arth_3540 ENOG4105CSH Transporter Arth_3543 ENOG4107YCY Transcriptional regulator Arth_3544 ENOG4108IJ0 Aspartate ammonia-lyase Arth_3545 ENOG4107QJT sodium dicarboxylate symporter Arth_3547 ENOG4105G9B Transcriptional regulator Arth_3548 ENOG4105CSV Glutaminase Arth_3550 ENOG4105C7K acetolactate synthase Arth_3559 ENOG4108IQI permease Arth_3560 ENOG4105D6E homoserine dehydrogenase Arth_3562 ENOG4105EW9 transcriptional regulator AsnC family Arth_3567 ENOG4105NX3 Membrane Arth_3576 ENOG4105CFM UPF0317 protein Arth_3582 ENOG41082I2 s4 domain protein Arth_3583 ENOG4105CEY Amp-dependent synthetase and ligase Arth_3590 ENOG4106G6Q Transcriptional regulator Arth_3591 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Arth_3592 ENOG4105C26 Dehydrogenase Arth_3598 ENOG4105CI2 imidazolone-5-propionate hydrolase Arth_3600 ENOG4105DZC cytosine deaminase Arth_3602 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Arth_3603 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Arth_3604 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Arth_3605 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Arth_3606 ENOG4105ETE Transcriptional regulator (LacI family Arth_3613 ENOG4105DU1 integral membrane protein, terc Arth_3624 ENOG4108JJB ABC transporter Arth_3625 ENOG4107R6F Alpha Beta Hydrolase Fold protein Arth_3626 ENOG4105EG6 Saccharopine dehydrogenase Arth_3627 ENOG4105C3R Methionine synthase Arth_3635 ENOG4108IQI permease Arth_3644 ENOG4105C2J ABC transporter Arth_3645 ENOG4105CNN ABC, transporter Arth_3650 ENOG4105CI2 imidazolone-5-propionate hydrolase Arth_3655 ENOG4105JAB phenazine biosynthesis protein, phzf family Arth_3659 ENOG4107QIZ NADH dehydrogenase Arth_3660 ENOG4108IEG Formate dehydrogenase Alpha subunit Arth_3668 ENOG4105EIG urea carboxylase-associated protein 1 Arth_3669 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Arth_3673 ENOG4105EKC Arth_3675 ENOG4105CK2 sodium dicarboxylate symporter Arth_3679 ENOG4105CX8 fg-gap repeat protein Arth_3684 ENOG4105CK5 oxidoreductase Arth_3687 ENOG4107T3P ABC, transporter Arth_3688 ENOG4105ETE Transcriptional regulator (LacI family Arth_3689 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) Arth_3690 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Arth_3691 ENOG41060W2 glyoxylate carboligase Arth_3692 ENOG4105BZW Glycerate kinase Arth_3694 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Arth_3700 ENOG4105EJQ L-serine dehydratase Arth_3705 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Arth_3706 ENOG4105DRR Transcriptional regulator, GntR family Arth_3710 ENOG41086KC Transcriptional regulator Arth_3713 ENOG4107RSM transcriptional regulator Arth_3715 ENOG4108DEF Globin Arth_3716 ENOG4105C94 Transporter Arth_3722 ENOG4105C5X domain protein Arth_3725 ENOG4105C26 Dehydrogenase Arth_3726 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) Arth_3727 ENOG4105CSH Transporter Arth_3736 ENOG4105CXB phosphoribosylaminoimidazole synthetase Arth_3740 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Arth_3741 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap Arth_3742 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Arth_3744 ENOG4105C26 Dehydrogenase Arth_3745 ENOG4105C94 Transporter Arth_3749 ENOG4105X1Q TOBE domain protein Arth_3754 ENOG4105CZN Potassium uptake protein Arth_3755 ENOG4105D7N magnesium and cobalt transport protein CorA Arth_3758 ENOG4108M8W Monooxygenase Arth_3759 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase Arth_3760 ENOG41090B9 response to stress Arth_3762 ENOG4105D4X repressor Arth_3764 ENOG4105KPY Small multidrug resistance protein Arth_3765 ENOG4105KPY Small multidrug resistance protein Arth_3769 ENOG4105BZU Histidine kinase Arth_3770 ENOG4108FN7 Aldo keto reductase Arth_3772 ENOG4105C1J atp-dependent rna helicase Arth_3776 ENOG4105CH2 amidohydrolase Arth_3777 ENOG4105CSH Transporter Arth_3779 ENOG4105DXI Major Facilitator superfamily Arth_3781 ENOG4105DJ2 Major Facilitator Superfamily Arth_3782 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Arth_3794 ENOG4105BZU Histidine kinase Arth_3796 ENOG4108HKT sucrose-6-phosphate hydrolase Arth_3798 ENOG4105C0D helicase Arth_3805 ENOG4105KNI merR family transcriptional Regulator Arth_3806 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Arth_3807 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Arth_3808 ENOG4105CFG Acts as a chaperone (By similarity) Arth_3815 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Arth_3820 ENOG4105CSH Transporter Arth_3822 ENOG4105C1G acyl-Coa dehydrogenase Arth_3824 ENOG4105CHR reductase Arth_3827 ENOG41082SX arsR family transcriptional regulator Arth_3829 ENOG4107RDB Major Facilitator Arth_3832 ENOG4105VPX protein, conserved in bacteria Arth_3833 ENOG4108V62 Rhodanese domain protein Arth_3836 ENOG41085GJ domain protein Arth_3837 ENOG41080RH Thioredoxin Arth_3839 ENOG4105C5X domain protein Arth_3840 ENOG4105KT5 UmuD protein Arth_3844 ENOG41082XB radical SAM domain protein Arth_3847 ENOG4105KJF protein tyrosine phosphatase Arth_3849 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Arth_3851 ENOG4107SVN transposase Arth_3853 ENOG4107SVN transposase Arth_3854 ENOG4105BZU Histidine kinase Arth_3856 ENOG4105C84 Histidine ammonia-lyase Arth_3862 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) Arth_3863 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Arth_3865 ENOG4108JJB ABC transporter Arth_3866 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein Arth_3868 ENOG4105KJM monovalent cation h antiporter subunit g Arth_3869 ENOG41080TA Multiple resistance and ph regulation protein f Arth_3870 ENOG4105SC1 monovalent cation H antiporter subunit E Arth_3871 ENOG4108JPZ Monovalent cation H antiporter subunit D Arth_3872 ENOG4105MKQ Monovalent cation H antiporter subunit C Arth_3873 ENOG4105D65 subunit l Arth_3876 ENOG4107S91 Sodium hydrogen exchanger Arth_3877 ENOG4105DHP deoxycytidine triphosphate deaminase Arth_3881 ENOG4105E8G Major facilitator Superfamily Arth_3882 ENOG4106NZI LysR family Transcriptional regulator Arth_3884 ENOG4105C26 Dehydrogenase Arth_3885 ENOG4105CUB amino acid Arth_3887 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Arth_3889 ENOG4105BZP glycoside hydrolase 15-related Arth_3890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Arth_3892 ENOG4105CKB glycosidase Arth_3896 ENOG4105ETE Transcriptional regulator (LacI family Arth_3897 ENOG4105DEN Luciferase family Arth_3905 ENOG4105CPU Monooxygenase Arth_3907 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) Arth_3908 ENOG4105CDA abc transporter atp-binding protein Arth_3909 ENOG4105E5Q amino acid AbC transporter Arth_3912 ENOG4105D7A ATP-binding protein Arth_3915 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein Arth_3916 ENOG4108426 dNA-binding protein Arth_3918 ENOG4105ETE Transcriptional regulator (LacI family Arth_3919 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Arth_3920 ENOG4105W0E 50S ribosomal protein L33 Arth_3921 ENOG4105KDC 50s ribosomal protein l28 Arth_3922 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) Arth_3926 ENOG4105CSV Glutaminase Arth_3932 ENOG4105E0A ABC, transporter Arth_3933 ENOG4108IHU transport system permease protein Arth_3934 ENOG4105DQ5 transport system permease protein Arth_3937 ENOG4108X07 Tetr family transcriptional regulator Arth_3946 ENOG4105K5B UPF0225 protein Arth_3948 ENOG4105CPC Aldo Keto reductase Arth_3949 ENOG4105CPC Aldo Keto reductase Arth_3950 ENOG4105ECR NmrA family Arth_3952 ENOG4107YVI ribose 5-phosphate isomerase Arth_3953 ENOG4105CMT Dihydroxyacetone kinase Arth_3955 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) Arth_3960 ENOG4107ZQV short-chain dehydrogenase reductase Arth_3970 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Arth_3974 ENOG4107YCY Transcriptional regulator Arth_3976 ENOG4108IJ0 Aspartate ammonia-lyase Arth_3978 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Arth_3983 ENOG4105EBR Carboxylesterase Arth_3984 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Arth_3985 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) Arth_3990 ENOG4105N14 lysine exporter protein LysE YggA Arth_3995 ENOG4108SGK Tetr family transcriptional regulator Arth_3997 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) Arth_3998 ENOG4105C0R drug resistance transporter emrb qaca subfamily Arth_4000 ENOG4105DXB Major Facilitator superfamily Arth_4003 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase Arth_4004 ENOG4105CTS PTS system mannitol-specific Arth_4006 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Arth_4007 ENOG41080Z8 PHOSPHOCARRIER protein Arth_4010 ENOG4105QE3 oxidoreductase Arth_4012 ENOG4105DCF alanine dehydrogenase Arth_4013 ENOG4105D9R oxidoreductase Arth_4019 ENOG4108YYH Nadph-dependent fmn reductase Arth_4021 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) Arth_4022 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Arth_4024 ENOG4105CEY Amp-dependent synthetase and ligase Arth_4026 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 Arth_4027 ENOG4105CPP Dehydrogenase, E1 component Arth_4029 ENOG4105CIH Imidazole acetol-phosphate transaminase Arth_4030 ENOG41082T9 Membrane Arth_4033 ENOG4107QTF adenylosuccinate lyase Arth_4034 ENOG4105GCF PGAM Arth_4038 ENOG4105NAU thioesterase Superfamily protein Arth_4042 ENOG41061H0 Monooxygenase Arth_4045 ENOG4105D2S major facilitator superfamily Arth_4046 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Arth_4049 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) Arth_4050 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Arth_4051 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family Arth_4052 ENOG4105J5G Transferase hexapeptide repeat containing protein Arth_4056 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Arth_4058 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Arth_4059 ENOG4105CMR udp-glucose 4-epimerase Arth_4061 ENOG4105D3Q Sugar transferase Arth_4063 ENOG4105DJB Major Facilitator Superfamily Arth_4064 ENOG4105DRR Transcriptional regulator, GntR family Arth_4068 ENOG4107TE5 Lipid kinase Arth_4070 ENOG4107HP6 Transcriptional regulator Arth_4071 ENOG4107QNJ CoA-transferase subunit B Arth_4073 ENOG4105CHU acetyl-coa acetyltransferase Arth_4074 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase Arth_4076 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase Arth_4077 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha Arth_4080 ENOG4107S9B Shikimate dehydrogenase Arth_4081 ENOG4105J4Q Transcriptional regulator Arth_4084 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Arth_4085 ENOG4105W8H transhydrogenase (subunit alpha Arth_4086 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Arth_4096 ENOG4105C6X Major Facilitator Arth_4097 ENOG4105VPX protein, conserved in bacteria Arth_4102 ENOG4108UZ3 Transporter Arth_4107 ENOG4105NQG DoxX Arth_4110 ENOG4105CDU Replicative dna helicase Arth_4115 ENOG4108UZX fmn reductase Arth_4117 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Arth_4118 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Arth_4120 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) Arth_4122 ENOG4107EF8 Glycosyl transferase (Group 1 Arth_4128 ENOG4105DFM M18 family aminopeptidase Arth_4133 ENOG4105C85 amino acid Arth_4134 ENOG4105WH1 Two component transcriptional regulator luxr family Arth_4135 ENOG4105BZU Histidine kinase Arth_4137 ENOG4105CJ1 ABC, transporter Arth_4139 ENOG4106UW1 Major Facilitator superfamily Arth_4142 ENOG4105DAA L-lactate Arth_4144 ENOG4105C5H ABC transporter Arth_4145 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) Arth_4147 ENOG4105WH1 Two component transcriptional regulator luxr family Arth_4148 ENOG4105BZU Histidine kinase Arth_4150 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Arth_4151 ENOG4105KVH Transcriptional regulator Arth_4156 ENOG4107TB6 phosphoglycerate mutase Arth_4157 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Arth_4161 ENOG4105C3M thioredoxin reductase Arth_4162 ENOG4105K63 Thioredoxin Arth_4166 ENOG4107QJE Chromosome Partitioning Protein Arth_4167 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) Arth_4169 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Arth_4170 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Arth_4172 ENOG41084CH 50S ribosomal protein l34 Arth_4176 ENOG4107QJE Chromosome Partitioning Protein Arth_4190 ENOG4108C33 Resolvase Arth_4195 ENOG4108Z6Z Transcriptional regulator Arth_4202 ENOG4105CRE cytochrome C Arth_4204 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Arth_4205 ENOG4107E6A Cytochrome p-450 Arth_4208 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Arth_4209 ENOG4107QIV Cytochrome c biogenesis protein Arth_4218 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Arth_4255 ENOG4105DWT malate dehydrogenase (quinone) Arth_4257 ENOG4105BZ1 (ABC) transporter Arth_4258 ENOG4105BZ1 (ABC) transporter Arth_4260 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Arth_4262 ENOG41082SX arsR family transcriptional regulator Arth_4265 ENOG41082SX arsR family transcriptional regulator Arth_4274 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Arth_4290 ENOG4108C33 Resolvase Arth_4295 ENOG4108Z6Z Transcriptional regulator Arth_4302 ENOG4105CRE cytochrome C Arth_4304 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Arth_4305 ENOG4107E6A Cytochrome p-450 Arth_4308 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Arth_4309 ENOG4107QIV Cytochrome c biogenesis protein Arth_4313 ENOG4108KQ5 Integrase catalytic subunit Arth_4314 ENOG4105D1F ATP-binding protein Arth_4323 ENOG4108F3G Type I restriction-modification system, R subunit Arth_4324 ENOG4108RAV Conserved protein Arth_4332 ENOG4105FA0 parb-like partition protein Arth_4341 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Arth_4346 ENOG4105FUY alpha subunit Arth_4350 ENOG4106517 Short-chain dehydrogenase reductase Sdr Arth_4353 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Arth_4355 ENOG4105D2X ABC transporter substrate-binding protein Arth_4359 ENOG4108UAU isochorismatase Arth_4361 ENOG4105CV8 reductase Arth_4362 ENOG4107SVN transposase Arth_4369 ENOG4107258 Transcriptional regulator Arth_4371 ENOG4105CPC Aldo Keto reductase Arth_4374 ENOG4105GAK amidohydrolase 2 Arth_4376 ENOG4105KHM amidohydrolase 2 Arth_4377 ENOG4105FF5 Membrane Arth_4379 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN Arth_4383 ENOG4108C33 Resolvase Arth_4386 ENOG4108C33 Resolvase Arth_4393 ENOG410836F Transposase Arth_4410 ENOG4107SVN transposase Arth_4414 ENOG4107XWI flavin reductase domain protein, FMN-binding Arth_4415 ENOG4105ETS cytosine purines uracil thiamine allantoin Arth_4419 ENOG4105CEI nitrite reductase Arth_4421 ENOG4105E3B Multicopper oxidase Arth_4429 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Arth_4432 ENOG4107QIV Cytochrome c biogenesis protein Arth_4433 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Arth_4446 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein Arth_4454 ENOG4105E4C Lytic transglycosylase catalytic Arth_4459 ENOG4108C33 Resolvase Arth_4464 ENOG4108Z6Z Transcriptional regulator Arth_4471 ENOG4105CRE cytochrome C Arth_4473 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Arth_4474 ENOG4107E6A Cytochrome p-450 Arth_4477 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Arth_4478 ENOG4107QIV Cytochrome c biogenesis protein Arth_4490 ENOG4107R16 Multicopper oxidase Arth_4491 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Arth_4493 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) Arth_4497 ENOG4105C8S subunit m Arth_4498 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Arth_4519 ENOG4107QJE Chromosome Partitioning Protein Arth_4520 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Arth_4522 ENOG4105D5G Transposase Arth_4526 ENOG4105DQR SNARE associated Golgi Arth_4531 ENOG4108SEA Esterase Arth_4533 ENOG41062D9 Histidine kinase Arth_4535 ENOG4105ETX regulatoR Arth_4536 ENOG410841Q phosphoesterase PA-phosphatase related protein