locus-tag	class	description
Arth_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Arth_0002	COG0592	DNA-directed DNA polymerase activity
Arth_0003	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Arth_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Arth_0005	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
Arth_0006	COG0187	DNA topoisomerase II activity
Arth_0007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Arth_0008	COG3266	domain, Protein
Arth_0013	COG0705	Rhomboid family
Arth_0014	COG2818	Glycosylase
Arth_0015	COG3291	Pkd domain containing protein
Arth_0015	COG4412	M6 family metalloprotease domain protein
Arth_0017	COG3764	Sortase (surface protein transpeptidase)
Arth_0020	COG2815	serine threonine protein kinase
Arth_0020	COG0515	serine threonine protein kinase
Arth_0021	COG0515	serine threonine protein kinase
Arth_0022	COG0768	penicillin binding
Arth_0025	COG1716	ATPase activity
Arth_0026	COG1716	ATPase activity
Arth_0028	COG1116	anion transmembrane transporter activity
Arth_0030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Arth_0031	COG1609	Transcriptional regulator
Arth_0035	COG4948	Mandelate Racemase Muconate Lactonizing
Arth_0035	COG4948	Mandelate Racemase Muconate Lactonizing
Arth_0037	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Arth_0038	COG0583	DNA-binding transcription factor activity
Arth_0050	COG0395	ABC-type sugar transport system, permease component
Arth_0053	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Arth_0054	COG1621	beta-fructofuranosidase activity
Arth_0062	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Arth_0068	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_0072	COG2755	lipolytic protein G-D-S-L family
Arth_0079	COG0586	Pfam SNARE associated Golgi protein
Arth_0080	COG1609	Transcriptional regulator
Arth_0081	COG1957	nucleoside hydrolase
Arth_0083	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Arth_0087	COG0673	inositol 2-dehydrogenase activity
Arth_0089	COG1175	transmembrane transport
Arth_0092	COG2186	Transcriptional regulator
Arth_0093	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Arth_0094	COG0477	Major facilitator Superfamily
Arth_0095	COG1984	allophanate hydrolase subunit 2
Arth_0096	COG4770	biotin carboxylase activity
Arth_0100	COG3707	response regulator
Arth_0102	COG0385	Bile acid
Arth_0104	COG0659	secondary active sulfate transmembrane transporter activity
Arth_0107	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Arth_0108	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Arth_0108	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Arth_0111	COG0561	phosphatase activity
Arth_0112	COG0584	glycerophosphoryl diester phosphodiesterase
Arth_0116	COG5002	protein histidine kinase activity
Arth_0118	COG4106	trans-aconitate 2-methyltransferase activity
Arth_0119	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Arth_0120	COG0406	alpha-ribazole phosphatase activity
Arth_0120	COG0328	RNA-DNA hybrid ribonuclease activity
Arth_0122	COG2267	carboxylic ester hydrolase activity
Arth_0123	COG1929	Belongs to the glycerate kinase type-1 family
Arth_0126	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_0128	COG2233	PERMEase
Arth_0129	COG0778	Nitroreductase
Arth_0134	COG3104	oligopeptide transport
Arth_0135	COG0154	amidase activity
Arth_0136	COG3340	Belongs to the peptidase S51 family
Arth_0137	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Arth_0139	COG1597	lipid kinase activity
Arth_0140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Arth_0141	COG0561	phosphatase activity
Arth_0145	COG2272	Belongs to the type-B carboxylesterase lipase family
Arth_0149	COG0037	tRNA processing
Arth_0151	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Arth_0152	COG0302	gtp cyclohydrolase
Arth_0153	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Arth_0154	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Arth_0160	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Arth_0161	COG2814	Major facilitator Superfamily
Arth_0165	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Arth_0168	COG0542	response to heat
Arth_0169	COG1506	peptidase
Arth_0169	COG0823	Involved in the tonB-independent uptake of proteins
Arth_0170	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Arth_0172	COG2376	Dihydroxyacetone kinase
Arth_0173	COG1461	Dihydroxyacetone kinase
Arth_0180	COG0363	glucosamine-6-phosphate deaminase activity
Arth_0181	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Arth_0182	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
Arth_0183	COG1940	carbohydrate kinase activity
Arth_0184	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Arth_0185	COG4608	Belongs to the ABC transporter superfamily
Arth_0186	COG0444	Belongs to the ABC transporter superfamily
Arth_0188	COG0747	negative chemotaxis
Arth_0190	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Arth_0191	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Arth_0192	COG2815	serine threonine protein kinase
Arth_0192	COG0515	serine threonine protein kinase
Arth_0197	COG2217	Heavy metal translocating P-type atpase
Arth_0198	COG2132	Multicopper oxidase
Arth_0205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Arth_0206	COG0306	phosphate transporter
Arth_0212	COG0798	PFAM Bile acid sodium symporter
Arth_0218	COG3384	dioxygenase
Arth_0219	COG1609	Transcriptional regulator
Arth_0224	COG2160	L-arabinose isomerase activity
Arth_0225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Arth_0228	COG1609	Transcriptional regulator
Arth_0231	COG2837	iron assimilation
Arth_0234	COG4948	Mandelate Racemase Muconate Lactonizing
Arth_0235	COG1802	Transcriptional regulator
Arth_0236	COG2271	Major facilitator Superfamily
Arth_0238	COG0586	Pfam SNARE associated Golgi protein
Arth_0241	COG0831	urea catabolic process
Arth_0242	COG0832	Belongs to the urease beta subunit family
Arth_0243	COG0804	urea catabolic process
Arth_0244	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Arth_0245	COG0830	nickel cation binding
Arth_0246	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Arth_0247	COG0829	nickel cation binding
Arth_0248	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
Arth_0250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Arth_0250	COG0723	plastoquinol--plastocyanin reductase activity
Arth_0253	COG1228	amidohydrolase
Arth_0255	COG1064	alcohol dehydrogenase
Arth_0257	COG2890	protein-(glutamine-N5) methyltransferase activity
Arth_0258	COG0438	transferase activity, transferring glycosyl groups
Arth_0261	COG2261	transglycosylase associated protein
Arth_0264	COG0667	Aldo Keto reductase
Arth_0265	COG0656	L-ascorbic acid biosynthetic process
Arth_0268	COG3360	Dodecin
Arth_0270	COG1937	Protein conserved in bacteria
Arth_0271	COG2186	Transcriptional regulator
Arth_0273	COG2084	Dehydrogenase
Arth_0274	COG2610	gluconate transmembrane transporter activity
Arth_0281	COG1215	transferase activity, transferring glycosyl groups
Arth_0283	COG1366	Belongs to the anti-sigma-factor antagonist family
Arth_0286	COG3486	L-lysine 6-monooxygenase (NADPH) activity
Arth_0289	COG0300	oxidoreductase activity
Arth_0291	COG0477	Major facilitator Superfamily
Arth_0295	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Arth_0299	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Arth_0299	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Arth_0299	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Arth_0300	COG1105	Belongs to the carbohydrate kinase PfkB family
Arth_0301	COG1349	DNA-binding transcription factor activity
Arth_0304	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Arth_0306	COG1609	Transcriptional regulator
Arth_0307	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Arth_0313	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Arth_0315	COG1140	nitrate reductase beta subunit
Arth_0319	COG2733	membrane
Arth_0321	COG3559	Exporter of polyketide antibiotics
Arth_0322	COG1131	(ABC) transporter
Arth_0334	COG0783	Belongs to the Dps family
Arth_0338	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Arth_0339	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Arth_0339	COG0574	Belongs to the PEP-utilizing enzyme family
Arth_0352	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Arth_0355	COG0438	transferase activity, transferring glycosyl groups
Arth_0356	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Arth_0357	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Arth_0357	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Arth_0358	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_0361	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Arth_0361	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Arth_0366	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_0367	COG1280	lysine exporter protein (LysE YggA)
Arth_0374	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Arth_0379	COG0010	Belongs to the arginase family
Arth_0380	COG2252	PERMEase
Arth_0384	COG0574	Belongs to the PEP-utilizing enzyme family
Arth_0384	COG3848	Pyruvate phosphate dikinase
Arth_0391	COG0697	spore germination
Arth_0393	COG0583	DNA-binding transcription factor activity
Arth_0395	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Arth_0395	COG1796	DNA polymerase
Arth_0396	COG0589	response to stress
Arth_0399	COG0601	transmembrane transport
Arth_0400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Arth_0401	COG0444	Belongs to the ABC transporter superfamily
Arth_0403	COG1621	beta-fructofuranosidase activity
Arth_0407	COG1302	Protein conserved in bacteria
Arth_0412	COG0366	Alpha amylase catalytic
Arth_0417	COG1609	Transcriptional regulator
Arth_0421	COG1024	Enoyl-CoA hydratase
Arth_0424	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Arth_0425	COG1621	beta-fructofuranosidase activity
Arth_0427	COG0395	ABC-type sugar transport system, permease component
Arth_0428	COG4209	transmembrane transport
Arth_0429	COG1609	Transcriptional regulator
Arth_0430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Arth_0433	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Arth_0434	COG1960	acyl-CoA dehydrogenase activity
Arth_0435	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Arth_0442	COG0596	Alpha beta hydrolase
Arth_0471	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Arth_0472	COG1278	Cold shock
Arth_0474	COG3848	Pyruvate phosphate dikinase
Arth_0474	COG0574	Belongs to the PEP-utilizing enzyme family
Arth_0476	COG3706	GGDEF domain
Arth_0479	COG4948	Mandelate Racemase Muconate Lactonizing
Arth_0480	COG0395	ABC-type sugar transport system, permease component
Arth_0481	COG1175	transmembrane transport
Arth_0485	COG2197	response regulator
Arth_0486	COG4585	Histidine kinase
Arth_0489	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Arth_0494	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Arth_0495	COG1609	Transcriptional regulator
Arth_0498	COG0395	ABC-type sugar transport system, permease component
Arth_0500	COG0673	inositol 2-dehydrogenase activity
Arth_0502	COG1904	glucuronate isomerase
Arth_0503	COG0246	Mannitol dehydrogenase
Arth_0504	COG4948	Mandelate Racemase Muconate Lactonizing
Arth_0508	COG0508	dehydrogenase complex catalyzes the overall conversion of
Arth_0509	COG0022	dehydrogenase e1 component
Arth_0509	COG0508	dehydrogenase complex catalyzes the overall conversion of
Arth_0510	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Arth_0511	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Arth_0512	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Arth_0517	COG0357	Ribosomal RNA small subunit methyltransferase G
Arth_0517	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Arth_0518	COG0191	fructose-bisphosphate aldolase activity
Arth_0522	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Arth_0526	COG1136	(ABC) transporter
Arth_0530	COG1832	CoA-binding protein
Arth_0533	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Arth_0534	COG1832	CoA-binding protein
Arth_0535	COG2315	Protein conserved in bacteria
Arth_0536	COG4762	Protein conserved in bacteria
Arth_0540	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Arth_0541	COG0047	phosphoribosylformylglycinamidine synthase activity
Arth_0544	COG1404	Belongs to the peptidase S8 family
Arth_0549	COG1846	Transcriptional regulator
Arth_0553	COG0519	Catalyzes the synthesis of GMP from XMP
Arth_0554	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Arth_0556	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Arth_0556	COG3323	Protein of unknown function (DUF1653)
Arth_0558	COG1196	nuclear chromosome segregation
Arth_0558	COG0739	heme binding
Arth_0558	COG0741	lytic transglycosylase activity
Arth_0559	COG0386	Belongs to the glutathione peroxidase family
Arth_0560	COG1063	alcohol dehydrogenase
Arth_0561	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Arth_0566	COG1309	transcriptional regulator
Arth_0570	COG0823	Involved in the tonB-independent uptake of proteins
Arth_0572	COG0673	inositol 2-dehydrogenase activity
Arth_0573	COG0673	inositol 2-dehydrogenase activity
Arth_0575	COG0395	ABC-type sugar transport system, permease component
Arth_0580	COG1940	carbohydrate kinase activity
Arth_0580	COG1846	Transcriptional regulator
Arth_0584	COG1396	sequence-specific DNA binding
Arth_0586	COG0642	Histidine kinase
Arth_0587	COG0745	RESPONSE REGULATOR receiver
Arth_0588	COG0477	Major facilitator Superfamily
Arth_0590	COG0028	Belongs to the TPP enzyme family
Arth_0593	COG0351	phosphomethylpyrimidine kinase
Arth_0594	COG1090	epimerase
Arth_0599	COG0343	queuine tRNA-ribosyltransferase activity
Arth_0605	COG3842	ATPase activity
Arth_0610	COG1960	acyl-CoA dehydrogenase activity
Arth_0614	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Arth_0617	COG0564	pseudouridine synthase activity
Arth_0621	COG2364	Membrane
Arth_0622	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Arth_0623	COG1201	RNA secondary structure unwinding
Arth_0624	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Arth_0624	COG0723	plastoquinol--plastocyanin reductase activity
Arth_0631	COG0563	adenylate kinase activity
Arth_0638	COG0596	Alpha beta hydrolase
Arth_0640	COG2226	methyltransferase
Arth_0644	COG0438	transferase activity, transferring glycosyl groups
Arth_0645	COG0590	tRNA wobble adenosine to inosine editing
Arth_0646	COG0671	phosphoesterase, PA-phosphatase related
Arth_0647	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Arth_0654	COG2205	protein histidine kinase activity
Arth_0655	COG0745	RESPONSE REGULATOR receiver
Arth_0659	COG2062	phosphohistidine phosphatase, SixA
Arth_0662	COG1309	transcriptional regulator
Arth_0663	COG1511	domain protein
Arth_0666	COG2186	Transcriptional regulator
Arth_0667	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Arth_0669	COG1959	2 iron, 2 sulfur cluster binding
Arth_0672	COG0514	ATP-dependent DNA helicase (RecQ)
Arth_0675	COG1505	serine-type exopeptidase activity
Arth_0679	COG0604	alcohol dehydrogenase
Arth_0681	COG1966	Carbon starvation protein
Arth_0685	COG0656	L-ascorbic acid biosynthetic process
Arth_0689	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Arth_0699	COG1842	Phage shock protein A
Arth_0716	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Arth_0717	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Arth_0721	COG0588	phosphoglycerate mutase activity
Arth_0723	COG5002	protein histidine kinase activity
Arth_0727	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Arth_0728	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Arth_0730	COG0215	cysteine-tRNA ligase activity
Arth_0737	COG0366	Alpha amylase catalytic
Arth_0738	COG0366	Alpha amylase catalytic
Arth_0739	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Arth_0742	COG1609	Transcriptional regulator
Arth_0743	COG0366	Alpha amylase catalytic
Arth_0745	COG1175	transmembrane transport
Arth_0746	COG3833	ABC-type maltose transport systems, permease component
Arth_0747	COG0366	Alpha amylase catalytic
Arth_0748	COG0277	FAD linked oxidase domain protein
Arth_0750	COG3842	ATPase activity
Arth_0759	COG2957	Belongs to the agmatine deiminase family
Arth_0760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Arth_0761	COG0783	Belongs to the Dps family
Arth_0762	COG0477	Major facilitator Superfamily
Arth_0764	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Arth_0764	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Arth_0765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Arth_0766	COG0509	glycine decarboxylation via glycine cleavage system
Arth_0767	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Arth_0769	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Arth_0770	COG3591	Belongs to the peptidase S1B family
Arth_0770	COG1864	DNA RNA non-specific endonuclease
Arth_0774	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Arth_0777	COG1278	Cold shock
Arth_0779	COG0459	protein refolding
Arth_0783	COG2205	protein histidine kinase activity
Arth_0784	COG0745	RESPONSE REGULATOR receiver
Arth_0790	COG1278	Cold shock
Arth_0795	COG0739	heme binding
Arth_0796	COG0791	NLP P60 protein
Arth_0796	COG3103	Sh3 type 3 domain protein
Arth_0796	COG1388	LysM domain
Arth_0797	COG0791	NLP P60 protein
Arth_0797	COG1388	LysM domain
Arth_0797	COG3103	Sh3 type 3 domain protein
Arth_0799	COG0746	molybdenum cofactor guanylyltransferase activity
Arth_0802	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Arth_0806	COG0488	(ABC) transporter
Arth_0807	COG1132	(ABC) transporter
Arth_0808	COG0494	nUDIX hydrolase
Arth_0812	COG0483	inositol monophosphate 1-phosphatase activity
Arth_0815	COG0045	succinate-CoA ligase (ADP-forming) activity
Arth_0818	COG0640	Transcriptional regulator
Arth_0819	COG1942	4-Oxalocrotonate Tautomerase
Arth_0820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Arth_0822	COG3962	Belongs to the TPP enzyme family
Arth_0825	COG0673	inositol 2-dehydrogenase activity
Arth_0826	COG1082	Xylose isomerase domain protein TIM barrel
Arth_0827	COG2814	Major facilitator Superfamily
Arth_0828	COG1846	Transcriptional regulator
Arth_0829	COG2814	Major facilitator Superfamily
Arth_0831	COG1172	Belongs to the binding-protein-dependent transport system permease family
Arth_0833	COG0673	inositol 2-dehydrogenase activity
Arth_0834	COG0673	inositol 2-dehydrogenase activity
Arth_0835	COG3718	enzyme involved in inositol metabolism
Arth_0837	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Arth_0839	COG2186	Transcriptional regulator
Arth_0841	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_0847	COG1396	sequence-specific DNA binding
Arth_0850	COG0347	Belongs to the P(II) protein family
Arth_0852	COG0028	Belongs to the TPP enzyme family
Arth_0862	COG1401	restriction endodeoxyribonuclease activity
Arth_0865	COG1309	transcriptional regulator
Arth_0866	COG5002	protein histidine kinase activity
Arth_0867	COG0745	RESPONSE REGULATOR receiver
Arth_0875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Arth_0880	COG1063	alcohol dehydrogenase
Arth_0881	COG1902	pentaerythritol trinitrate reductase activity
Arth_0884	COG2376	Dihydroxyacetone kinase
Arth_0885	COG0698	ribose 5-phosphate isomerase
Arth_0886	COG1250	3-hydroxyacyl-CoA dehydrogenase
Arth_0887	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_0888	COG2271	Major facilitator Superfamily
Arth_0889	COG0149	triose-phosphate isomerase activity
Arth_0902	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Arth_0907	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Arth_0910	COG0667	Aldo Keto reductase
Arth_0918	COG1254	Belongs to the acylphosphatase family
Arth_0924	COG3655	Transcriptional regulator
Arth_0928	COG0477	Major facilitator Superfamily
Arth_0933	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
Arth_0945	COG1846	Transcriptional regulator
Arth_0947	COG1253	flavin adenine dinucleotide binding
Arth_0950	COG0584	glycerophosphoryl diester phosphodiesterase
Arth_0955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Arth_0966	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Arth_0967	COG1597	lipid kinase activity
Arth_0969	COG0028	Belongs to the TPP enzyme family
Arth_0971	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Arth_0972	COG1113	amino acid transport
Arth_0986	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Arth_0988	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Arth_0993	COG4974	Belongs to the 'phage' integrase family
Arth_1002	COG0515	serine threonine protein kinase
Arth_1002	COG2815	serine threonine protein kinase
Arth_1009	COG0456	acetyltransferase
Arth_1010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Arth_1014	COG2186	Transcriptional regulator
Arth_1022	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Arth_1023	COG1349	DNA-binding transcription factor activity
Arth_1029	COG2350	Protein conserved in bacteria
Arth_1034	COG1349	DNA-binding transcription factor activity
Arth_1035	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Arth_1036	COG0747	negative chemotaxis
Arth_1037	COG0601	transmembrane transport
Arth_1039	COG0444	Belongs to the ABC transporter superfamily
Arth_1040	COG4608	Belongs to the ABC transporter superfamily
Arth_1041	COG0667	Aldo Keto reductase
Arth_1042	COG3836	Belongs to the HpcH HpaI aldolase family
Arth_1044	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_1045	COG3540	Alkaline phosphatase
Arth_1055	COG1278	Cold shock
Arth_1058	COG0673	inositol 2-dehydrogenase activity
Arth_1063	COG2072	flavoprotein involved in K transport
Arth_1065	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_1069	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Arth_1073	COG2268	Band 7 protein
Arth_1076	COG1012	belongs to the aldehyde dehydrogenase family
Arth_1079	COG1024	Enoyl-CoA hydratase
Arth_1080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Arth_1081	COG0446	pyridine nucleotide-disulphide oxidoreductase
Arth_1082	COG0477	Major facilitator Superfamily
Arth_1083	COG1396	sequence-specific DNA binding
Arth_1089	COG2271	Major facilitator Superfamily
Arth_1090	COG0138	bifunctional purine biosynthesis protein purh
Arth_1092	COG2838	Isocitrate dehydrogenase
Arth_1096	COG2815	serine threonine protein kinase
Arth_1096	COG0515	serine threonine protein kinase
Arth_1100	COG1136	(ABC) transporter
Arth_1102	COG4213	ABC transporter substrate-binding protein
Arth_1106	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Arth_1108	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Arth_1109	COG0531	amino acid
Arth_1116	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Arth_1117	COG1131	(ABC) transporter
Arth_1121	COG0708	Exodeoxyribonuclease III
Arth_1122	COG0180	Tryptophanyl-tRNA synthetase
Arth_1128	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Arth_1131	COG2009	succinate dehydrogenase
Arth_1133	COG1473	amidohydrolase
Arth_1133	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Arth_1134	COG1846	Transcriptional regulator
Arth_1135	COG1764	response to oxidative stress
Arth_1136	COG2130	NADP-dependent
Arth_1137	COG1744	ABC transporter substrate-binding protein PnrA-like
Arth_1144	COG0586	Pfam SNARE associated Golgi protein
Arth_1145	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Arth_1146	COG3956	TIGRFAM MazG family protein
Arth_1147	COG0148	phosphopyruvate hydratase activity
Arth_1152	COG1252	NADH dehydrogenase
Arth_1158	COG0559	Belongs to the binding-protein-dependent transport system permease family
Arth_1160	COG0183	Belongs to the thiolase family
Arth_1161	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Arth_1163	COG2017	converts alpha-aldose to the beta-anomer
Arth_1165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Arth_1167	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Arth_1169	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Arth_1171	COG1331	Highly conserved protein containing a thioredoxin domain
Arth_1173	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Arth_1174	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Arth_1180	COG1309	transcriptional regulator
Arth_1181	COG0114	fumarate hydratase activity
Arth_1182	COG0288	reversible hydration of carbon dioxide
Arth_1184	COG1494	fructose-1,6-bisphosphatase
Arth_1188	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Arth_1198	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Arth_1200	COG1376	ErfK ybiS ycfS ynhG family protein
Arth_1210	COG0714	Associated with various cellular activities
Arth_1211	COG0084	hydrolase, TatD family'
Arth_1212	COG3583	domain protein
Arth_1213	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Arth_1214	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Arth_1215	COG0488	(ABC) transporter
Arth_1216	COG1309	transcriptional regulator
Arth_1217	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Arth_1219	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Arth_1220	COG0193	aminoacyl-tRNA hydrolase activity
Arth_1226	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Arth_1229	COG3979	chitinase
Arth_1232	COG1215	transferase activity, transferring glycosyl groups
Arth_1239	COG1216	Glycosyl transferase, family 2
Arth_1242	COG0702	epimerase
Arth_1246	COG1988	membrane-bound metal-dependent
Arth_1248	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Arth_1249	COG0446	pyridine nucleotide-disulphide oxidoreductase
Arth_1257	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Arth_1257	COG1648	precorrin-2 dehydrogenase activity
Arth_1258	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Arth_1260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Arth_1267	COG0243	molybdopterin cofactor binding
Arth_1268	COG2223	nitrite transmembrane transporter activity
Arth_1269	COG0477	Major facilitator Superfamily
Arth_1271	COG4770	biotin carboxylase activity
Arth_1272	COG0424	maF-like protein
Arth_1275	COG2409	Drug exporters of the RND superfamily
Arth_1281	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Arth_1282	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_1283	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Arth_1283	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Arth_1288	COG0714	Associated with various cellular activities
Arth_1292	COG0631	protein serine/threonine phosphatase activity
Arth_1296	COG1674	ftsk spoiiie
Arth_1298	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Arth_1299	COG0483	inositol monophosphate 1-phosphatase activity
Arth_1302	COG0251	oxidation-reduction process
Arth_1303	COG4565	transcriptional regulatory protein
Arth_1304	COG3290	protein histidine kinase activity
Arth_1305	COG2851	Citrate transporter
Arth_1306	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Arth_1307	COG0154	amidase activity
Arth_1308	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Arth_1309	COG0583	DNA-binding transcription factor activity
Arth_1310	COG1063	alcohol dehydrogenase
Arth_1313	COG1228	amidohydrolase
Arth_1314	COG0588	phosphoglycerate mutase activity
Arth_1317	COG2873	o-acetylhomoserine
Arth_1318	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Arth_1320	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Arth_1327	COG0400	carboxylic ester hydrolase activity
Arth_1330	COG0423	glycine-tRNA ligase activity
Arth_1332	COG0204	Acyl-transferase
Arth_1338	COG0358	DNA primase activity
Arth_1341	COG2814	Major facilitator Superfamily
Arth_1343	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Arth_1367	COG0052	Belongs to the universal ribosomal protein uS2 family
Arth_1368	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Arth_1369	COG0528	UMP kinase activity
Arth_1370	COG0233	cytoplasmic translational termination
Arth_1373	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Arth_1376	COG3275	phosphorelay sensor kinase activity
Arth_1378	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Arth_1382	COG0022	dehydrogenase e1 component
Arth_1383	COG0508	dehydrogenase complex catalyzes the overall conversion of
Arth_1385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Arth_1387	COG1960	acyl-CoA dehydrogenase activity
Arth_1392	COG0589	response to stress
Arth_1396	COG3290	protein histidine kinase activity
Arth_1399	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Arth_1400	COG0750	zinc metalloprotease
Arth_1404	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Arth_1407	COG0442	prolyl-tRNA aminoacylation
Arth_1413	COG0779	Required for maturation of 30S ribosomal subunits
Arth_1416	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Arth_1417	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Arth_1419	COG0590	tRNA wobble adenosine to inosine editing
Arth_1420	COG3118	belongs to the thioredoxin family
Arth_1424	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Arth_1431	COG3483	tryptophan 2,3-dioxygenase activity
Arth_1433	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Arth_1434	COG1185	polyribonucleotide nucleotidyltransferase activity
Arth_1435	COG0612	Peptidase, M16
Arth_1441	COG0745	RESPONSE REGULATOR receiver
Arth_1442	COG5002	protein histidine kinase activity
Arth_1446	COG0521	Mo-molybdopterin cofactor biosynthetic process
Arth_1448	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Arth_1452	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Arth_1453	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Arth_1454	COG1674	ftsk spoiiie
Arth_1456	COG1058	Belongs to the CinA family
Arth_1456	COG1546	Belongs to the CinA family
Arth_1457	COG1396	sequence-specific DNA binding
Arth_1460	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Arth_1461	COG2137	regulation of response to DNA damage stimulus
Arth_1462	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Arth_1463	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Arth_1464	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Arth_1465	COG2813	Specifically methylates the guanine in position
Arth_1466	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Arth_1468	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Arth_1470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Arth_1471	COG0131	Imidazoleglycerol-phosphate dehydratase
Arth_1472	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Arth_1473	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Arth_1477	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Arth_1478	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Arth_1479	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Arth_1480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Arth_1481	COG2261	transglycosylase associated protein
Arth_1483	COG2814	Major facilitator Superfamily
Arth_1486	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Arth_1489	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Arth_1490	COG0072	phenylalanine-tRNA ligase activity
Arth_1490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Arth_1496	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Arth_1497	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Arth_1498	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Arth_1499	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Arth_1500	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Arth_1501	COG1438	arginine binding
Arth_1502	COG0137	argininosuccinate synthase activity
Arth_1503	COG0165	Argininosuccinate lyase
Arth_1504	COG0259	pyridoxamine-phosphate oxidase activity
Arth_1506	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Arth_1506	COG2169	Transcriptional regulator
Arth_1508	COG2094	Belongs to the DNA glycosylase MPG family
Arth_1509	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Arth_1510	COG3415	Transposase
Arth_1510	COG2801	Transposase and inactivated derivatives
Arth_1512	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Arth_1514	COG0647	UMP catabolic process
Arth_1517	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Arth_1518	COG0497	DNA recombination
Arth_1519	COG0504	CTP synthase activity
Arth_1524	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Arth_1525	COG2079	MmgE PrpD family protein
Arth_1529	COG3290	protein histidine kinase activity
Arth_1532	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Arth_1533	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Arth_1536	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Arth_1538	COG1160	GTP binding
Arth_1539	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Arth_1540	COG0509	glycine decarboxylation via glycine cleavage system
Arth_1541	COG1716	ATPase activity
Arth_1545	COG1192	Involved in chromosome partitioning
Arth_1546	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Arth_1548	COG1940	carbohydrate kinase activity
Arth_1553	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Arth_1554	COG0515	serine threonine protein kinase
Arth_1554	COG2815	serine threonine protein kinase
Arth_1555	COG3942	CHAP domain
Arth_1555	COG1388	LysM domain
Arth_1557	COG0142	geranyltranstransferase activity
Arth_1561	COG2001	Belongs to the MraZ family
Arth_1562	COG0275	rRNA processing
Arth_1564	COG0768	penicillin binding
Arth_1567	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Arth_1568	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Arth_1569	COG0772	Belongs to the SEDS family
Arth_1570	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Arth_1571	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Arth_1573	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Arth_1576	COG1799	cell septum assembly
Arth_1578	COG3599	regulation of cell shape
Arth_1579	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Arth_1585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Arth_1586	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Arth_1587	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_1591	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Arth_1592	COG0174	glutamine synthetase
Arth_1593	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Arth_1595	COG0765	amino acid transport
Arth_1596	COG1126	abc transporter atp-binding protein
Arth_1604	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Arth_1605	COG0321	lipoyl(octanoyl) transferase activity
Arth_1608	COG4946	Tricorn protease homolog
Arth_1608	COG0793	Belongs to the peptidase S41A family
Arth_1609	COG1764	response to oxidative stress
Arth_1611	COG0508	dehydrogenase complex catalyzes the overall conversion of
Arth_1612	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Arth_1613	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Arth_1617	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Arth_1622	COG1271	oxidase subunit
Arth_1623	COG1294	oxidase, subunit
Arth_1624	COG4988	ABC transporter
Arth_1625	COG0456	acetyltransferase
Arth_1627	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Arth_1628	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Arth_1628	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Arth_1631	COG1435	thymidine kinase activity
Arth_1636	COG0756	dUTP diphosphatase activity
Arth_1641	COG0569	domain protein
Arth_1642	COG0531	amino acid
Arth_1643	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Arth_1644	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Arth_1645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Arth_1649	COG0667	Aldo Keto reductase
Arth_1654	COG1250	3-hydroxyacyl-CoA dehydrogenase
Arth_1654	COG1024	Enoyl-CoA hydratase
Arth_1655	COG0183	Belongs to the thiolase family
Arth_1656	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Arth_1661	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Arth_1670	COG0242	peptide deformylase activity
Arth_1671	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Arth_1673	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Arth_1676	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Arth_1676	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Arth_1677	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Arth_1677	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Arth_1678	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Arth_1679	COG0140	phosphoribosyl-ATP diphosphatase activity
Arth_1680	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Arth_1681	COG0107	imidazoleglycerol-phosphate synthase activity
Arth_1683	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Arth_1687	COG0134	indole-3-glycerol-phosphate synthase activity
Arth_1688	COG0133	tryptophan synthase activity
Arth_1689	COG0159	tryptophan synthase activity
Arth_1690	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Arth_1691	COG0069	glutamate synthase activity
Arth_1691	COG0070	glutamate synthase
Arth_1691	COG0067	glutamate synthase
Arth_1698	COG5492	domain, Protein
Arth_1699	COG1609	Transcriptional regulator
Arth_1700	COG3119	arylsulfatase activity
Arth_1701	COG3119	arylsulfatase activity
Arth_1708	COG3119	arylsulfatase activity
Arth_1709	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Arth_1710	COG1940	carbohydrate kinase activity
Arth_1713	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Arth_1714	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Arth_1716	COG3119	arylsulfatase activity
Arth_1722	COG1234	tRNA 3'-trailer cleavage
Arth_1723	COG1012	belongs to the aldehyde dehydrogenase family
Arth_1727	COG2124	cytochrome p450
Arth_1730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Arth_1733	COG4325	translation initiation factor activity
Arth_1735	COG0531	amino acid
Arth_1739	COG5416	Lipopolysaccharide assembly protein A domain
Arth_1742	COG0589	response to stress
Arth_1744	COG0686	Belongs to the AlaDH PNT family
Arth_1745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Arth_1746	COG0765	amino acid transport
Arth_1747	COG0765	amino acid transport
Arth_1748	COG1126	abc transporter atp-binding protein
Arth_1753	COG0477	Major facilitator Superfamily
Arth_1756	COG0277	FAD linked oxidase domain protein
Arth_1756	COG0247	lactate metabolic process
Arth_1758	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Arth_1759	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Arth_1760	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Arth_1762	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Arth_1763	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Arth_1764	COG0006	proline dipeptidase activity
Arth_1771	COG5001	Diguanylate cyclase
Arth_1771	COG3300	MHYT domain
Arth_1773	COG0745	RESPONSE REGULATOR receiver
Arth_1775	COG5002	protein histidine kinase activity
Arth_1777	COG0789	Transcriptional regulator
Arth_1781	COG0745	RESPONSE REGULATOR receiver
Arth_1784	COG3572	ergothioneine biosynthetic process
Arth_1787	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_1788	COG0477	Major facilitator Superfamily
Arth_1789	COG1063	alcohol dehydrogenase
Arth_1791	COG1105	Belongs to the carbohydrate kinase PfkB family
Arth_1792	COG3958	Transketolase
Arth_1793	COG3959	Transketolase, thiamine diphosphate binding domain
Arth_1794	COG1063	alcohol dehydrogenase
Arth_1795	COG1414	Transcriptional regulator
Arth_1798	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Arth_1799	COG1737	Transcriptional regulator
Arth_1800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Arth_1801	COG2140	Oxalate decarboxylase
Arth_1803	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Arth_1804	COG1063	alcohol dehydrogenase
Arth_1805	COG1063	alcohol dehydrogenase
Arth_1806	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_1807	COG0800	Aldolase
Arth_1809	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Arth_1811	COG1129	ABC transporter
Arth_1812	COG1172	Belongs to the binding-protein-dependent transport system permease family
Arth_1813	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_1814	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Arth_1815	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Arth_1816	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Arth_1817	COG2814	Major facilitator Superfamily
Arth_1819	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_1821	COG1063	alcohol dehydrogenase
Arth_1823	COG1063	alcohol dehydrogenase
Arth_1824	COG1879	ABC-type sugar transport system periplasmic component
Arth_1826	COG1172	Belongs to the binding-protein-dependent transport system permease family
Arth_1828	COG3387	PFAM Glycoside hydrolase 15-related
Arth_1830	COG1053	succinate dehydrogenase
Arth_1831	COG0693	protein deglycase activity
Arth_1832	COG0583	DNA-binding transcription factor activity
Arth_1835	COG1609	Transcriptional regulator
Arth_1852	COG4702	Belongs to the UPF0303 family
Arth_1854	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Arth_1854	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Arth_1855	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Arth_1857	COG1024	Enoyl-CoA hydratase
Arth_1859	COG4670	ketone body catabolic process
Arth_1863	COG1175	transmembrane transport
Arth_1864	COG0395	ABC-type sugar transport system, permease component
Arth_1866	COG0800	Aldolase
Arth_1867	COG0464	growth
Arth_1870	COG2354	Protein conserved in bacteria
Arth_1875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Arth_1876	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Arth_1877	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Arth_1890	COG3711	transcriptional antiterminator
Arth_1891	COG2723	6-phospho-beta-galactosidase activity
Arth_1892	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Arth_1892	COG2190	(PTS) system
Arth_1892	COG1263	PTS System
Arth_1893	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Arth_1895	COG2814	Major facilitator Superfamily
Arth_1899	COG2186	Transcriptional regulator
Arth_1901	COG4948	Mandelate Racemase Muconate Lactonizing
Arth_1904	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Arth_1912	COG1082	Xylose isomerase domain protein TIM barrel
Arth_1914	COG1172	Belongs to the binding-protein-dependent transport system permease family
Arth_1915	COG1129	ABC transporter
Arth_1918	COG1609	Transcriptional regulator
Arth_1919	COG4213	ABC transporter substrate-binding protein
Arth_1921	COG1172	Belongs to the binding-protein-dependent transport system permease family
Arth_1925	COG1609	Transcriptional regulator
Arth_1930	COG0583	DNA-binding transcription factor activity
Arth_1933	COG3485	protocatechuate 3,4-dioxygenase
Arth_1934	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Arth_1936	COG1454	alcohol dehydrogenase
Arth_1937	COG0501	Belongs to the peptidase M48B family
Arth_1940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Arth_1944	COG1012	belongs to the aldehyde dehydrogenase family
Arth_1948	COG3684	Belongs to the aldolase LacD family
Arth_1950	COG0673	inositol 2-dehydrogenase activity
Arth_1952	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Arth_1957	COG2226	methyltransferase
Arth_1959	COG0477	Major facilitator Superfamily
Arth_1965	COG1396	sequence-specific DNA binding
Arth_1966	COG0492	ferredoxin-NADP+ reductase activity
Arth_1967	COG2226	methyltransferase
Arth_1978	COG2124	cytochrome p450
Arth_1979	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Arth_1980	COG0673	inositol 2-dehydrogenase activity
Arth_1981	COG1126	abc transporter atp-binding protein
Arth_1982	COG0765	amino acid transport
Arth_1985	COG2199	diguanylate cyclase activity
Arth_1985	COG3287	FIST C domain
Arth_1985	COG2200	EAL domain
Arth_1986	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Arth_1987	COG4867	von Willebrand factor, type A
Arth_1991	COG0454	-acetyltransferase
Arth_1992	COG0563	adenylate kinase activity
Arth_1993	COG1414	Transcriptional regulator
Arth_1995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Arth_1995	COG0574	Belongs to the PEP-utilizing enzyme family
Arth_2002	COG2755	lipolytic protein G-D-S-L family
Arth_2002	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Arth_2004	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Arth_2007	COG0405	Gamma-glutamyltransferase
Arth_2009	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Arth_2013	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Arth_2015	COG2186	Transcriptional regulator
Arth_2017	COG0702	epimerase
Arth_2019	COG2828	Protein conserved in bacteria
Arth_2026	COG1643	Atp-dependent helicase
Arth_2032	COG0009	L-threonylcarbamoyladenylate synthase
Arth_2038	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Arth_2038	COG3608	succinylglutamate desuccinylase aspartoacylase
Arth_2045	COG2197	response regulator
Arth_2046	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Arth_2051	COG0179	Fumarylacetoacetate (FAA) hydrolase
Arth_2054	COG2814	Major facilitator Superfamily
Arth_2055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Arth_2062	COG2050	protein possibly involved in aromatic compounds catabolism
Arth_2064	COG4552	Acetyltransferase involved in intracellular survival and related
Arth_2065	COG0539	negative regulation of cytoplasmic translation
Arth_2068	COG1739	Uncharacterized protein family UPF0029
Arth_2069	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Arth_2069	COG0237	dephospho-CoA kinase activity
Arth_2070	COG0556	nucleotide-excision repair
Arth_2071	COG0861	Integral membrane protein TerC family
Arth_2075	COG4106	trans-aconitate 2-methyltransferase activity
Arth_2076	COG1132	(ABC) transporter
Arth_2078	COG2188	Transcriptional regulator
Arth_2080	COG0546	phosphoglycolate phosphatase activity
Arth_2082	COG0322	excinuclease ABC activity
Arth_2083	COG1660	Displays ATPase and GTPase activities
Arth_2084	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Arth_2085	COG1481	regulation of sporulation
Arth_2086	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Arth_2087	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Arth_2088	COG0126	phosphoglycerate kinase activity
Arth_2089	COG0149	triose-phosphate isomerase activity
Arth_2090	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Arth_2092	COG0363	glucosamine-6-phosphate deaminase activity
Arth_2095	COG0166	Belongs to the GPI family
Arth_2096	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Arth_2098	COG0109	protoheme IX farnesyltransferase activity
Arth_2099	COG1612	heme a metabolic process
Arth_2101	COG1131	(ABC) transporter
Arth_2106	COG0396	ATPase activity
Arth_2107	COG2151	metal-sulfur cluster biosynthetic enzyme
Arth_2109	COG0318	PFAM AMP-dependent synthetase and ligase
Arth_2112	COG1122	ATPase activity
Arth_2113	COG1268	BioY protein
Arth_2114	COG0488	(ABC) transporter
Arth_2119	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_2122	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_2123	COG3830	Belongs to the UPF0237 family
Arth_2123	COG0560	Phosphoserine phosphatase
Arth_2124	COG1119	ATPase activity
Arth_2127	COG0254	rRNA binding
Arth_2130	COG2855	membrane
Arth_2140	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Arth_2141	COG0297	glycogen (starch) synthase activity
Arth_2144	COG0183	Belongs to the thiolase family
Arth_2145	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_2149	COG0435	Glutathione S-transferase
Arth_2156	COG0579	oxidoreductase
Arth_2157	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Arth_2162	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Arth_2166	COG0656	L-ascorbic acid biosynthetic process
Arth_2167	COG1968	undecaprenyl-diphosphatase activity
Arth_2168	COG0215	cysteine-tRNA ligase activity
Arth_2170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Arth_2173	COG1222	aaa ATPase
Arth_2174	COG4122	O-methyltransferase activity
Arth_2176	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Arth_2177	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Arth_2178	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Arth_2179	COG0545	Peptidyl-prolyl cis-trans isomerase
Arth_2183	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Arth_2184	COG0805	protein transport
Arth_2185	COG4581	dead DEAH box helicase
Arth_2186	COG1574	metal-dependent hydrolase with the TIM-barrel fold
Arth_2187	COG1216	Glycosyl transferase, family 2
Arth_2192	COG0823	Involved in the tonB-independent uptake of proteins
Arth_2192	COG4946	Tricorn protease homolog
Arth_2192	COG1506	peptidase
Arth_2193	COG0242	peptide deformylase activity
Arth_2196	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Arth_2199	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Arth_2200	COG4974	Belongs to the 'phage' integrase family
Arth_2208	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Arth_2209	COG1845	cytochrome c oxidase, subunit III
Arth_2210	COG2010	Cytochrome c
Arth_2211	COG0723	plastoquinol--plastocyanin reductase activity
Arth_2212	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Arth_2214	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Arth_2216	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Arth_2217	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Arth_2219	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Arth_2221	COG0167	dihydroorotate dehydrogenase activity
Arth_2224	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Arth_2225	COG1381	Involved in DNA repair and RecF pathway recombination
Arth_2226	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Arth_2227	COG3590	peptidase
Arth_2228	COG1316	TRANSCRIPTIONal
Arth_2229	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Arth_2231	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Arth_2234	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Arth_2235	COG0484	heat shock protein binding
Arth_2236	COG1420	regulation of RNA biosynthetic process
Arth_2239	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Arth_2240	COG0481	GTPase activity
Arth_2242	COG0268	Binds directly to 16S ribosomal RNA
Arth_2245	COG2183	response to ionizing radiation
Arth_2246	COG1307	EDD domain protein, DegV family
Arth_2247	COG0495	leucyl-tRNA aminoacylation
Arth_2248	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Arth_2249	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Arth_2250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Arth_2252	COG0656	L-ascorbic acid biosynthetic process
Arth_2254	COG0438	transferase activity, transferring glycosyl groups
Arth_2256	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Arth_2258	COG1758	RNA polymerase activity
Arth_2259	COG0194	GDP metabolic process
Arth_2260	COG0194	GDP metabolic process
Arth_2261	COG0284	orotidine-5'-phosphate decarboxylase activity
Arth_2262	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Arth_2263	COG0505	Belongs to the CarA family
Arth_2265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Arth_2266	COG0540	Belongs to the ATCase OTCase family
Arth_2267	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Arth_2269	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Arth_2270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Arth_2272	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Arth_2274	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Arth_2275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Arth_2278	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Arth_2281	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Arth_2285	COG1414	Transcriptional regulator
Arth_2287	COG1053	succinate dehydrogenase
Arth_2289	COG0477	Major facilitator Superfamily
Arth_2291	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Arth_2293	COG0124	histidyl-tRNA synthetase
Arth_2295	COG1196	nuclear chromosome segregation
Arth_2297	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Arth_2298	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Arth_2299	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Arth_2301	COG2255	four-way junction helicase activity
Arth_2302	COG0632	four-way junction helicase activity
Arth_2303	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Arth_2304	COG0217	transcriptional regulatory protein
Arth_2305	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Arth_2306	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Arth_2309	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Arth_2314	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Arth_2317	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Arth_2318	COG0587	DNA-directed DNA polymerase activity
Arth_2323	COG2135	peptidase activity
Arth_2336	COG1388	LysM domain
Arth_2336	COG0791	NLP P60 protein
Arth_2336	COG3103	Sh3 type 3 domain protein
Arth_2340	COG1234	tRNA 3'-trailer cleavage
Arth_2343	COG1126	abc transporter atp-binding protein
Arth_2344	COG0765	amino acid transport
Arth_2345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Arth_2352	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_2355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Arth_2356	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Arth_2357	COG1780	Probably involved in ribonucleotide reductase function
Arth_2359	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Arth_2360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Arth_2364	COG1012	belongs to the aldehyde dehydrogenase family
Arth_2366	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Arth_2374	COG0714	Associated with various cellular activities
Arth_2378	COG1653	transport
Arth_2379	COG1846	Transcriptional regulator
Arth_2379	COG1940	carbohydrate kinase activity
Arth_2380	COG2813	Specifically methylates the guanine in position
Arth_2381	COG0492	ferredoxin-NADP+ reductase activity
Arth_2382	COG2824	Alkylphosphonate utilization operon protein PhnA
Arth_2385	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Arth_2387	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Arth_2388	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Arth_2389	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Arth_2390	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Arth_2391	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Arth_2392	COG0351	phosphomethylpyrimidine kinase
Arth_2392	COG0352	thiamine-phosphate diphosphorylase activity
Arth_2392	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Arth_2393	COG1530	ribonuclease E activity
Arth_2395	COG0105	UTP biosynthetic process
Arth_2397	COG0285	dihydrofolate synthase activity
Arth_2398	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Arth_2401	COG0525	valine-tRNA ligase activity
Arth_2402	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Arth_2403	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Arth_2404	COG0740	serine-type endopeptidase activity
Arth_2405	COG0740	serine-type endopeptidase activity
Arth_2406	COG0544	peptidyl-prolyl cis-trans isomerase activity
Arth_2413	COG0668	transmembrane transport
Arth_2417	COG1946	Acyl-CoA thioesterase
Arth_2421	COG5416	Lipopolysaccharide assembly protein A domain
Arth_2425	COG0673	inositol 2-dehydrogenase activity
Arth_2426	COG1609	Transcriptional regulator
Arth_2427	COG0657	acetylesterase activity
Arth_2427	COG2755	lipolytic protein G-D-S-L family
Arth_2429	COG1940	carbohydrate kinase activity
Arth_2430	COG2115	Belongs to the xylose isomerase family
Arth_2431	COG1070	Carbohydrate kinase
Arth_2432	COG2017	converts alpha-aldose to the beta-anomer
Arth_2436	COG0242	peptide deformylase activity
Arth_2442	COG3022	response to hydroperoxide
Arth_2444	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Arth_2445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Arth_2447	COG1045	serine acetyltransferase
Arth_2448	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_2449	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Arth_2451	COG1063	alcohol dehydrogenase
Arth_2452	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_2454	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Arth_2457	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Arth_2458	COG0477	Major facilitator Superfamily
Arth_2464	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Arth_2467	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Arth_2468	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Arth_2469	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Arth_2471	COG4974	Belongs to the 'phage' integrase family
Arth_2473	COG0606	chelatase, subunit chli
Arth_2474	COG0792	nuclease activity
Arth_2476	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Arth_2478	COG0681	Belongs to the peptidase S26 family
Arth_2479	COG0335	large ribosomal subunit rRNA binding
Arth_2480	COG0336	Belongs to the RNA methyltransferase TrmD family
Arth_2481	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Arth_2482	COG1837	Belongs to the UPF0109 family
Arth_2483	COG0228	four-way junction DNA binding
Arth_2485	COG2514	catechol 2,3-dioxygenase activity
Arth_2490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Arth_2493	COG0477	Major facilitator Superfamily
Arth_2500	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Arth_2501	COG0571	ribonuclease III activity
Arth_2502	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Arth_2504	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Arth_2505	COG0300	oxidoreductase activity
Arth_2509	COG0742	ribosomal rna small subunit methyltransferase
Arth_2514	COG1181	Belongs to the D-alanine--D-alanine ligase family
Arth_2515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Arth_2517	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Arth_2518	COG0066	3-isopropylmalate dehydratase activity
Arth_2519	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Arth_2520	COG1414	Transcriptional regulator
Arth_2526	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Arth_2527	COG0179	Fumarylacetoacetate (FAA) hydrolase
Arth_2529	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Arth_2530	COG0473	3-isopropylmalate dehydrogenase activity
Arth_2534	COG1136	(ABC) transporter
Arth_2534	COG0577	efflux transmembrane transporter activity
Arth_2536	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Arth_2537	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Arth_2538	COG0440	acetolactate synthase activity
Arth_2540	COG0129	dihydroxy-acid dehydratase activity
Arth_2541	COG0583	DNA-binding transcription factor activity
Arth_2542	COG0088	Forms part of the polypeptide exit tunnel
Arth_2548	COG0747	negative chemotaxis
Arth_2549	COG0579	oxidoreductase
Arth_2550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Arth_2551	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Arth_2552	COG1846	Transcriptional regulator
Arth_2553	COG1305	Transglutaminase-like
Arth_2555	COG0179	Fumarylacetoacetate (FAA) hydrolase
Arth_2557	COG1104	cysteine desulfurase activity
Arth_2559	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Arth_2560	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Arth_2563	COG1113	amino acid transport
Arth_2565	COG0022	dehydrogenase e1 component
Arth_2566	COG0508	dehydrogenase complex catalyzes the overall conversion of
Arth_2568	COG0477	Major facilitator Superfamily
Arth_2573	COG0419	ATPase involved in DNA repair
Arth_2574	COG0420	3'-5' exonuclease activity
Arth_2575	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Arth_2579	COG0586	Pfam SNARE associated Golgi protein
Arth_2580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Arth_2581	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Arth_2582	COG1234	tRNA 3'-trailer cleavage
Arth_2583	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Arth_2585	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Arth_2587	COG1335	isochorismatase
Arth_2590	COG0363	glucosamine-6-phosphate deaminase activity
Arth_2593	COG1902	pentaerythritol trinitrate reductase activity
Arth_2596	COG0628	permease
Arth_2599	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
Arth_2601	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Arth_2604	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Arth_2605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Arth_2606	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Arth_2607	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Arth_2608	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Arth_2609	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Arth_2610	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Arth_2611	COG0356	it plays a direct role in the translocation of protons across the membrane
Arth_2614	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Arth_2617	COG0009	L-threonylcarbamoyladenylate synthase
Arth_2618	COG2890	protein-(glutamine-N5) methyltransferase activity
Arth_2619	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Arth_2621	COG0083	homoserine kinase activity
Arth_2622	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Arth_2623	COG0460	homoserine dehydrogenase
Arth_2624	COG0019	diaminopimelate decarboxylase activity
Arth_2625	COG0018	arginyl-trna synthetase
Arth_2632	COG1643	Atp-dependent helicase
Arth_2633	COG0537	adenosine 5'-monophosphoramidase activity
Arth_2634	COG1064	alcohol dehydrogenase
Arth_2640	COG1121	(ABC) transporter
Arth_2643	COG1253	flavin adenine dinucleotide binding
Arth_2645	COG0567	Dehydrogenase, E1 component
Arth_2645	COG0508	dehydrogenase complex catalyzes the overall conversion of
Arth_2651	COG1595	DNA-templated transcription, initiation
Arth_2653	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Arth_2655	COG0483	inositol monophosphate 1-phosphatase activity
Arth_2656	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Arth_2659	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Arth_2660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Arth_2662	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Arth_2663	COG0739	heme binding
Arth_2665	COG2884	Cell division ATP-binding protein ftsE
Arth_2666	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Arth_2679	COG1088	dTDP-glucose 4,6-dehydratase activity
Arth_2688	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Arth_2693	COG1216	Glycosyl transferase, family 2
Arth_2699	COG2902	Dehydrogenase
Arth_2706	COG0653	protein targeting
Arth_2707	COG3214	Protein conserved in bacteria
Arth_2708	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Arth_2710	COG5401	PFAM Sporulation and spore germination
Arth_2711	COG5002	protein histidine kinase activity
Arth_2716	COG0714	Associated with various cellular activities
Arth_2721	COG4172	Belongs to the ABC transporter superfamily
Arth_2722	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Arth_2723	COG0601	transmembrane transport
Arth_2727	COG0482	sulfurtransferase activity
Arth_2730	COG0697	spore germination
Arth_2734	COG1597	lipid kinase activity
Arth_2735	COG0484	heat shock protein binding
Arth_2736	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Arth_2737	COG1595	DNA-templated transcription, initiation
Arth_2741	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Arth_2742	COG2086	electron transfer activity
Arth_2743	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Arth_2745	COG1842	Phage shock protein A
Arth_2747	COG0415	Belongs to the DNA photolyase family
Arth_2749	COG1615	UPF0182 protein
Arth_2750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Arth_2754	COG2816	NAD+ diphosphatase activity
Arth_2760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Arth_2761	COG2011	ABC-type metal ion transport system permease component
Arth_2763	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Arth_2765	COG0113	porphobilinogen synthase activity
Arth_2767	COG0181	hydroxymethylbilane synthase activity
Arth_2772	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Arth_2773	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Arth_2778	COG2154	pterin-4-alpha-carbinolamine dehydratase
Arth_2779	COG2022	thiamine diphosphate biosynthetic process
Arth_2782	COG0352	thiamine-phosphate diphosphorylase activity
Arth_2784	COG0557	exoribonuclease II activity
Arth_2785	COG0513	Belongs to the DEAD box helicase family
Arth_2786	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Arth_2788	COG0006	proline dipeptidase activity
Arth_2790	COG2239	Acts as a magnesium transporter
Arth_2793	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Arth_2795	COG1595	DNA-templated transcription, initiation
Arth_2801	COG1126	abc transporter atp-binding protein
Arth_2802	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Arth_2803	COG0765	amino acid transport
Arth_2804	COG0765	amino acid transport
Arth_2805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Arth_2806	COG2171	N-acyltransferase activity
Arth_2809	COG3226	Transcriptional regulator
Arth_2810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Arth_2819	COG4172	Belongs to the ABC transporter superfamily
Arth_2822	COG4166	transmembrane transport
Arth_2823	COG4172	Belongs to the ABC transporter superfamily
Arth_2826	COG0601	transmembrane transport
Arth_2827	COG4166	transmembrane transport
Arth_2831	COG0012	GTP binding
Arth_2833	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Arth_2835	COG1570	exodeoxyribonuclease VII activity
Arth_2836	COG1722	exodeoxyribonuclease VII activity
Arth_2837	COG2326	polyphosphate kinase activity
Arth_2840	COG1174	glycine betaine transport
Arth_2841	COG1174	glycine betaine transport
Arth_2843	COG1162	GTPase activity
Arth_2845	COG2971	BadF BadG BcrA BcrD
Arth_2847	COG0583	DNA-binding transcription factor activity
Arth_2848	COG2814	Major facilitator Superfamily
Arth_2849	COG0626	cystathionine gamma-synthase activity
Arth_2855	COG0598	Magnesium transport protein CorA
Arth_2857	COG3848	Pyruvate phosphate dikinase
Arth_2857	COG0574	Belongs to the PEP-utilizing enzyme family
Arth_2860	COG0488	(ABC) transporter
Arth_2861	COG1090	epimerase
Arth_2864	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Arth_2865	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Arth_2869	COG0519	Catalyzes the synthesis of GMP from XMP
Arth_2869	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Arth_2873	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Arth_2874	COG0516	GMP reductase activity
Arth_2875	COG1404	Belongs to the peptidase S8 family
Arth_2876	COG1132	(ABC) transporter
Arth_2880	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Arth_2880	COG2755	lipolytic protein G-D-S-L family
Arth_2883	COG2072	flavoprotein involved in K transport
Arth_2886	COG0459	protein refolding
Arth_2887	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Arth_2889	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Arth_2890	COG1472	Belongs to the glycosyl hydrolase 3 family
Arth_2891	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Arth_2892	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Arth_2895	COG0802	atpase or kinase
Arth_2896	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Arth_2897	COG1105	Belongs to the carbohydrate kinase PfkB family
Arth_2900	COG0438	transferase activity, transferring glycosyl groups
Arth_2901	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Arth_2906	COG0667	Aldo Keto reductase
Arth_2911	COG0736	holo-[acyl-carrier-protein] synthase activity
Arth_2912	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Arth_2913	COG1072	(Pantothenic acid kinase))
Arth_2915	COG1970	mechanosensitive ion channel activity
Arth_2916	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Arth_2917	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Arth_2918	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Arth_2919	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Arth_2924	COG0455	bacterial-type flagellum organization
Arth_2932	COG2894	cell division
Arth_2937	COG0745	RESPONSE REGULATOR receiver
Arth_2938	COG0101	tRNA pseudouridine synthase activity
Arth_2939	COG0203	ribosomal protein L17
Arth_2940	COG0202	RNA polymerase activity
Arth_2941	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Arth_2942	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Arth_2943	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Arth_2944	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Arth_2945	COG3191	aminopeptidase activity
Arth_2947	COG0395	ABC-type sugar transport system, permease component
Arth_2948	COG1653	transport
Arth_2951	COG0318	PFAM AMP-dependent synthetase and ligase
Arth_2952	COG2124	cytochrome p450
Arth_2953	COG1216	Glycosyl transferase, family 2
Arth_2953	COG1442	glycosyl transferase family 8
Arth_2954	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Arth_2955	COG0563	adenylate kinase activity
Arth_2957	COG0200	Binds to the 23S rRNA
Arth_2958	COG1841	ribosomal large subunit assembly
Arth_2959	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Arth_2961	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Arth_2962	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Arth_2963	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Arth_2964	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Arth_2965	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Arth_2966	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Arth_2967	COG0255	Belongs to the universal ribosomal protein uL29 family
Arth_2968	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Arth_2969	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Arth_2970	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Arth_2971	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Arth_2972	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Arth_2973	COG0089	rRNA binding
Arth_2974	COG0088	Forms part of the polypeptide exit tunnel
Arth_2975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Arth_2976	COG0051	transcription antitermination factor activity, RNA binding
Arth_2979	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Arth_2980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Arth_2981	COG0049	tRNA binding
Arth_2982	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Arth_2983	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Arth_2984	COG0085	RNA polymerase activity
Arth_2986	COG0183	Belongs to the thiolase family
Arth_2987	COG0442	prolyl-tRNA aminoacylation
Arth_2988	COG0737	Belongs to the 5'-nucleotidase family
Arth_2989	COG0222	ribosome binding
Arth_2990	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Arth_2993	COG0081	regulation of translation
Arth_2994	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Arth_2997	COG0436	Aminotransferase
Arth_2998	COG2197	response regulator
Arth_3008	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Arth_3010	COG3485	protocatechuate 3,4-dioxygenase
Arth_3012	COG0745	RESPONSE REGULATOR receiver
Arth_3013	COG0456	acetyltransferase
Arth_3014	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Arth_3018	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Arth_3021	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Arth_3024	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Arth_3025	COG0738	Major facilitator superfamily
Arth_3027	COG2030	dehydratase
Arth_3029	COG0659	secondary active sulfate transmembrane transporter activity
Arth_3035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Arth_3037	COG4989	oxidoreductase activity
Arth_3040	COG1175	transmembrane transport
Arth_3042	COG1940	carbohydrate kinase activity
Arth_3044	COG0702	epimerase
Arth_3046	COG1595	DNA-templated transcription, initiation
Arth_3047	COG0706	membrane insertase activity
Arth_3053	COG0754	glutathionylspermidine amidase activity
Arth_3055	COG1960	acyl-CoA dehydrogenase activity
Arth_3057	COG5650	phosphatidylinositol metabolic process
Arth_3059	COG1733	regulation of RNA biosynthetic process
Arth_3060	COG1051	belongs to the nudix hydrolase family
Arth_3063	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Arth_3066	COG0318	PFAM AMP-dependent synthetase and ligase
Arth_3068	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Arth_3070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Arth_3073	COG1666	GTP binding
Arth_3074	COG0501	Belongs to the peptidase M48B family
Arth_3080	COG1116	anion transmembrane transporter activity
Arth_3081	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Arth_3082	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Arth_3083	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Arth_3085	COG0531	amino acid
Arth_3095	COG1012	belongs to the aldehyde dehydrogenase family
Arth_3096	COG3835	regulator
Arth_3098	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Arth_3098	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Arth_3104	COG2186	Transcriptional regulator
Arth_3116	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Arth_3119	COG1690	Belongs to the RtcB family
Arth_3124	COG0175	sulfate reduction
Arth_3125	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Arth_3127	COG2860	membrane
Arth_3132	COG2226	methyltransferase
Arth_3133	COG1169	isochorismate synthase
Arth_3134	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Arth_3135	COG0765	amino acid transport
Arth_3138	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Arth_3139	COG1609	Transcriptional regulator
Arth_3140	COG1621	beta-fructofuranosidase activity
Arth_3141	COG0395	ABC-type sugar transport system, permease component
Arth_3142	COG1175	transmembrane transport
Arth_3144	COG1609	Transcriptional regulator
Arth_3147	COG1175	transmembrane transport
Arth_3148	COG0395	ABC-type sugar transport system, permease component
Arth_3151	COG0018	arginyl-trna synthetase
Arth_3153	COG4948	Mandelate Racemase Muconate Lactonizing
Arth_3157	COG0436	Aminotransferase
Arth_3161	COG2072	flavoprotein involved in K transport
Arth_3184	COG1404	Belongs to the peptidase S8 family
Arth_3189	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Arth_3189	COG2755	lipolytic protein G-D-S-L family
Arth_3190	COG2755	lipolytic protein G-D-S-L family
Arth_3190	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Arth_3191	COG0508	dehydrogenase complex catalyzes the overall conversion of
Arth_3192	COG0022	dehydrogenase e1 component
Arth_3195	COG0489	protein tyrosine kinase activity
Arth_3203	COG1215	transferase activity, transferring glycosyl groups
Arth_3205	COG0438	transferase activity, transferring glycosyl groups
Arth_3207	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Arth_3211	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Arth_3213	COG1024	Enoyl-CoA hydratase
Arth_3214	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Arth_3215	COG2151	metal-sulfur cluster biosynthetic enzyme
Arth_3216	COG3396	Phenylacetate-CoA oxygenase
Arth_3217	COG3460	Phenylacetate-CoA oxygenase
Arth_3218	COG3396	Phenylacetate-CoA oxygenase
Arth_3221	COG0489	protein tyrosine kinase activity
Arth_3227	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Arth_3228	COG1316	TRANSCRIPTIONal
Arth_3238	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Arth_3240	COG0280	phosphate acetyltransferase
Arth_3240	COG0857	belongs to the CobB CobQ family
Arth_3242	COG2814	Major facilitator Superfamily
Arth_3246	COG2050	protein possibly involved in aromatic compounds catabolism
Arth_3254	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Arth_3255	COG1012	belongs to the aldehyde dehydrogenase family
Arth_3255	COG2030	dehydratase
Arth_3256	COG2050	protein possibly involved in aromatic compounds catabolism
Arth_3258	COG1528	Iron-storage protein
Arth_3259	COG1595	DNA-templated transcription, initiation
Arth_3266	COG1250	3-hydroxyacyl-CoA dehydrogenase
Arth_3267	COG1024	Enoyl-CoA hydratase
Arth_3268	COG0183	Belongs to the thiolase family
Arth_3272	COG0412	Dienelactone hydrolase
Arth_3274	COG2146	nitrite reductase [NAD(P)H] activity
Arth_3275	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Arth_3277	COG0488	(ABC) transporter
Arth_3278	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Arth_3279	COG1121	(ABC) transporter
Arth_3281	COG1266	CAAX protease self-immunity
Arth_3283	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Arth_3289	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Arth_3291	COG0785	Cytochrome C biogenesis protein
Arth_3293	COG0406	alpha-ribazole phosphatase activity
Arth_3294	COG2353	YceI-like domain
Arth_3297	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Arth_3299	COG0560	Phosphoserine phosphatase
Arth_3302	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Arth_3303	COG3458	cephalosporin-C deacetylase activity
Arth_3304	COG1070	Carbohydrate kinase
Arth_3305	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_3305	COG3347	Dehydrogenase
Arth_3307	COG3254	rhamnose metabolic process
Arth_3310	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_3311	COG0667	Aldo Keto reductase
Arth_3313	COG2755	lipolytic protein G-D-S-L family
Arth_3314	COG0395	ABC-type sugar transport system, permease component
Arth_3315	COG4209	transmembrane transport
Arth_3316	COG1653	transport
Arth_3317	COG5578	integral membrane protein
Arth_3320	COG2814	Major facilitator Superfamily
Arth_3322	COG0395	ABC-type sugar transport system, permease component
Arth_3323	COG1175	transmembrane transport
Arth_3327	COG0395	ABC-type sugar transport system, permease component
Arth_3328	COG1175	transmembrane transport
Arth_3333	COG0659	secondary active sulfate transmembrane transporter activity
Arth_3336	COG4948	Mandelate Racemase Muconate Lactonizing
Arth_3337	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Arth_3339	COG0673	inositol 2-dehydrogenase activity
Arth_3340	COG1609	Transcriptional regulator
Arth_3344	COG0640	Transcriptional regulator
Arth_3345	COG0123	including yeast histone deacetylase and acetoin utilization protein
Arth_3346	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Arth_3347	COG0569	domain protein
Arth_3348	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Arth_3349	COG4941	Belongs to the sigma-70 factor family
Arth_3351	COG1082	Xylose isomerase domain protein TIM barrel
Arth_3352	COG0248	Ppx GppA phosphatase
Arth_3355	COG1754	DNA topoisomerase type I activity
Arth_3355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Arth_3358	COG2890	protein-(glutamine-N5) methyltransferase activity
Arth_3359	COG1432	Conserved Protein
Arth_3367	COG1205	dead DEAH box helicase
Arth_3367	COG1111	helicase
Arth_3375	COG0494	nUDIX hydrolase
Arth_3376	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Arth_3378	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Arth_3382	COG1349	DNA-binding transcription factor activity
Arth_3383	COG1609	Transcriptional regulator
Arth_3386	COG0395	ABC-type sugar transport system, permease component
Arth_3392	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Arth_3399	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Arth_3400	COG1408	metallophosphoesterase
Arth_3401	COG1132	(ABC) transporter
Arth_3402	COG1132	(ABC) transporter
Arth_3403	COG1132	(ABC) transporter
Arth_3405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Arth_3406	COG0151	Belongs to the GarS family
Arth_3410	COG1301	dicarboxylic acid transport
Arth_3413	COG1953	Uracil, thiamine, allantoin
Arth_3414	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Arth_3419	COG0667	Aldo Keto reductase
Arth_3420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Arth_3422	COG3608	succinylglutamate desuccinylase aspartoacylase
Arth_3422	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Arth_3423	COG2252	PERMEase
Arth_3424	COG0590	tRNA wobble adenosine to inosine editing
Arth_3426	COG3285	dna ligase
Arth_3426	COG1793	dna ligase
Arth_3428	COG2233	PERMEase
Arth_3430	COG1953	Uracil, thiamine, allantoin
Arth_3431	COG1414	Transcriptional regulator
Arth_3435	COG3257	ureidoglycine aminohydrolase activity
Arth_3439	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Arth_3441	COG0179	Fumarylacetoacetate (FAA) hydrolase
Arth_3442	COG3387	PFAM Glycoside hydrolase 15-related
Arth_3447	COG0484	heat shock protein binding
Arth_3451	COG4335	DNA alkylation repair
Arth_3453	COG0667	Aldo Keto reductase
Arth_3454	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Arth_3457	COG0589	response to stress
Arth_3461	COG0438	transferase activity, transferring glycosyl groups
Arth_3464	COG1609	Transcriptional regulator
Arth_3465	COG2182	Extracellular solute-binding protein
Arth_3469	COG0673	inositol 2-dehydrogenase activity
Arth_3471	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Arth_3472	COG3237	CsbD-like
Arth_3473	COG4152	abc transporter atp-binding protein
Arth_3482	COG1902	pentaerythritol trinitrate reductase activity
Arth_3482	COG0446	pyridine nucleotide-disulphide oxidoreductase
Arth_3484	COG0477	Major facilitator Superfamily
Arth_3488	COG0693	protein deglycase activity
Arth_3490	COG2197	response regulator
Arth_3491	COG4585	Histidine kinase
Arth_3492	COG0745	RESPONSE REGULATOR receiver
Arth_3493	COG0745	RESPONSE REGULATOR receiver
Arth_3496	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Arth_3497	COG1414	Transcriptional regulator
Arth_3498	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Arth_3499	COG0477	Major facilitator Superfamily
Arth_3503	COG3226	Transcriptional regulator
Arth_3504	COG4977	sequence-specific DNA binding
Arth_3505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Arth_3511	COG1012	belongs to the aldehyde dehydrogenase family
Arth_3512	COG0363	glucosamine-6-phosphate deaminase activity
Arth_3513	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Arth_3514	COG2190	(PTS) system
Arth_3514	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Arth_3514	COG1263	PTS System
Arth_3516	COG2190	(PTS) system
Arth_3516	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Arth_3516	COG1263	PTS System
Arth_3521	COG1802	Transcriptional regulator
Arth_3524	COG3971	2-oxopent-4-enoate hydratase activity
Arth_3526	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Arth_3528	COG3265	gluconokinase activity
Arth_3529	COG2610	gluconate transmembrane transporter activity
Arth_3540	COG0477	Major facilitator Superfamily
Arth_3543	COG2186	Transcriptional regulator
Arth_3544	COG1027	Aspartate ammonia-lyase
Arth_3545	COG1301	dicarboxylic acid transport
Arth_3547	COG2508	Transcriptional regulator
Arth_3548	COG2066	Belongs to the glutaminase family
Arth_3550	COG0028	Belongs to the TPP enzyme family
Arth_3559	COG0833	amino acid
Arth_3560	COG0460	homoserine dehydrogenase
Arth_3561	COG1012	belongs to the aldehyde dehydrogenase family
Arth_3567	COG3739	integral membrane protein
Arth_3576	COG4336	lyase activity
Arth_3582	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Arth_3583	COG0318	PFAM AMP-dependent synthetase and ligase
Arth_3590	COG1737	Transcriptional regulator
Arth_3592	COG1012	belongs to the aldehyde dehydrogenase family
Arth_3597	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Arth_3598	COG1228	amidohydrolase
Arth_3600	COG0402	S-adenosylhomocysteine deaminase activity
Arth_3602	COG2084	Dehydrogenase
Arth_3603	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Arth_3603	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Arth_3604	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Arth_3605	COG0673	inositol 2-dehydrogenase activity
Arth_3606	COG1609	Transcriptional regulator
Arth_3624	COG3845	ABC transporter
Arth_3625	COG0596	Alpha beta hydrolase
Arth_3626	COG3268	Saccharopine dehydrogenase
Arth_3627	COG1410	methionine synthase
Arth_3627	COG0646	methionine synthase
Arth_3635	COG0833	amino acid
Arth_3645	COG1172	Belongs to the binding-protein-dependent transport system permease family
Arth_3650	COG1228	amidohydrolase
Arth_3659	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Arth_3660	COG3383	formate dehydrogenase (NAD+) activity
Arth_3668	COG3665	Urea carboxylase-associated protein
Arth_3675	COG1301	dicarboxylic acid transport
Arth_3679	COG3401	FG-GAP repeat protein
Arth_3682	COG0673	inositol 2-dehydrogenase activity
Arth_3684	COG0673	inositol 2-dehydrogenase activity
Arth_3687	COG1653	transport
Arth_3688	COG1609	Transcriptional regulator
Arth_3689	COG3622	Belongs to the hyi family
Arth_3690	COG2084	Dehydrogenase
Arth_3691	COG3960	tartronate-semialdehyde synthase activity
Arth_3692	COG1929	Belongs to the glycerate kinase type-1 family
Arth_3693	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Arth_3694	COG0745	RESPONSE REGULATOR receiver
Arth_3700	COG1760	l-serine dehydratase
Arth_3705	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Arth_3706	COG1802	Transcriptional regulator
Arth_3710	COG2197	response regulator
Arth_3713	COG0583	DNA-binding transcription factor activity
Arth_3715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Arth_3715	COG1017	nitric oxide dioxygenase activity
Arth_3716	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Arth_3722	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Arth_3726	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Arth_3727	COG0477	Major facilitator Superfamily
Arth_3731	COG2205	protein histidine kinase activity
Arth_3736	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Arth_3742	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Arth_3745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Arth_3749	COG3585	molybdate ion transport
Arth_3754	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Arth_3755	COG0598	Magnesium transport protein CorA
Arth_3758	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Arth_3759	COG0135	phosphoribosylanthranilate isomerase activity
Arth_3764	COG2076	Multidrug Resistance protein
Arth_3765	COG2076	Multidrug Resistance protein
Arth_3769	COG5001	Diguanylate cyclase
Arth_3769	COG3300	MHYT domain
Arth_3770	COG0667	Aldo Keto reductase
Arth_3773	COG1113	amino acid transport
Arth_3777	COG0477	Major facilitator Superfamily
Arth_3779	COG0477	Major facilitator Superfamily
Arth_3781	COG2807	transmembrane transport
Arth_3782	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Arth_3794	COG2202	Pas domain
Arth_3794	COG2205	protein histidine kinase activity
Arth_3796	COG1621	beta-fructofuranosidase activity
Arth_3798	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Arth_3804	COG2267	carboxylic ester hydrolase activity
Arth_3805	COG0789	Transcriptional regulator
Arth_3806	COG0484	heat shock protein binding
Arth_3807	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Arth_3808	COG0443	Heat shock 70 kDa protein
Arth_3812	COG2409	Drug exporters of the RND superfamily
Arth_3815	COG2226	methyltransferase
Arth_3817	COG1280	lysine exporter protein (LysE YggA)
Arth_3818	COG0542	response to heat
Arth_3820	COG0477	Major facilitator Superfamily
Arth_3822	COG1960	acyl-CoA dehydrogenase activity
Arth_3824	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_3827	COG0640	Transcriptional regulator
Arth_3829	COG2814	Major facilitator Superfamily
Arth_3832	COG1937	Protein conserved in bacteria
Arth_3833	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Arth_3836	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Arth_3837	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Arth_3839	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Arth_3844	COG0731	radical SAM domain protein
Arth_3847	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Arth_3849	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Arth_3852	COG2318	DinB family
Arth_3854	COG2200	EAL domain
Arth_3854	COG2199	diguanylate cyclase activity
Arth_3856	COG2986	histidine ammonia-lyase
Arth_3862	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Arth_3863	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Arth_3865	COG1122	ATPase activity
Arth_3866	COG4721	ABC-type cobalt transport system, permease component
Arth_3868	COG1320	monovalent cation:proton antiporter activity
Arth_3869	COG2212	antiporter activity
Arth_3870	COG1863	multisubunit Na H antiporter MnhE subunit
Arth_3873	COG2111	Na H antiporter
Arth_3873	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Arth_3876	COG0475	glutathione-regulated potassium exporter activity
Arth_3877	COG0717	Belongs to the dCTP deaminase family
Arth_3882	COG0583	DNA-binding transcription factor activity
Arth_3884	COG1012	belongs to the aldehyde dehydrogenase family
Arth_3885	COG0531	amino acid
Arth_3887	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Arth_3889	COG3387	PFAM Glycoside hydrolase 15-related
Arth_3890	COG0745	RESPONSE REGULATOR receiver
Arth_3892	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Arth_3894	COG1175	transmembrane transport
Arth_3896	COG1609	Transcriptional regulator
Arth_3897	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Arth_3904	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Arth_3907	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Arth_3908	COG1126	abc transporter atp-binding protein
Arth_3912	COG0433	COG0433 Predicted ATPase
Arth_3915	COG3336	cytochrome c oxidase
Arth_3916	COG0776	regulation of translation
Arth_3918	COG1609	Transcriptional regulator
Arth_3919	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Arth_3920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Arth_3921	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Arth_3922	COG1017	nitric oxide dioxygenase activity
Arth_3922	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Arth_3926	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
Arth_3926	COG2066	Belongs to the glutaminase family
Arth_3932	COG1120	ATPase activity
Arth_3933	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Arth_3934	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Arth_3937	COG1309	transcriptional regulator
Arth_3946	COG3012	SEC-C Motif Domain Protein
Arth_3948	COG0667	Aldo Keto reductase
Arth_3949	COG0667	Aldo Keto reductase
Arth_3950	COG0702	epimerase
Arth_3952	COG0698	ribose 5-phosphate isomerase
Arth_3953	COG2376	Dihydroxyacetone kinase
Arth_3954	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_3955	COG1082	Xylose isomerase domain protein TIM barrel
Arth_3957	COG3959	Transketolase, thiamine diphosphate binding domain
Arth_3958	COG3958	Transketolase
Arth_3960	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_3970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Arth_3972	COG3550	peptidyl-serine autophosphorylation
Arth_3974	COG2186	Transcriptional regulator
Arth_3976	COG1027	Aspartate ammonia-lyase
Arth_3978	COG0039	L-malate dehydrogenase activity
Arth_3985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Arth_3990	COG1280	lysine exporter protein (LysE YggA)
Arth_3995	COG1309	transcriptional regulator
Arth_3997	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Arth_3998	COG0477	Major facilitator Superfamily
Arth_3999	COG0477	Major facilitator Superfamily
Arth_4000	COG2814	Major facilitator Superfamily
Arth_4001	COG1846	Transcriptional regulator
Arth_4003	COG0246	Mannitol dehydrogenase
Arth_4004	COG2213	PTS system mannitol-specific
Arth_4004	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Arth_4006	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Arth_4010	COG0277	FAD linked oxidase domain protein
Arth_4012	COG0686	Belongs to the AlaDH PNT family
Arth_4013	COG0673	inositol 2-dehydrogenase activity
Arth_4019	COG0431	NADPH-dependent FMN reductase
Arth_4021	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Arth_4022	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Arth_4023	COG0589	response to stress
Arth_4024	COG0318	PFAM AMP-dependent synthetase and ligase
Arth_4026	COG0508	dehydrogenase complex catalyzes the overall conversion of
Arth_4027	COG0022	dehydrogenase e1 component
Arth_4029	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Arth_4030	COG1950	PFAM Membrane protein of
Arth_4033	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Arth_4034	COG0406	alpha-ribazole phosphatase activity
Arth_4038	COG1607	acyl-coa hydrolase
Arth_4039	COG1840	ABC-type Fe3 transport system, periplasmic component
Arth_4041	COG1178	ABC-type Fe3 transport system permease component
Arth_4045	COG2814	Major facilitator Superfamily
Arth_4046	COG0243	molybdopterin cofactor binding
Arth_4049	COG1970	mechanosensitive ion channel activity
Arth_4050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Arth_4056	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Arth_4058	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Arth_4059	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Arth_4061	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Arth_4063	COG2271	Major facilitator Superfamily
Arth_4064	COG1802	Transcriptional regulator
Arth_4068	COG1597	lipid kinase activity
Arth_4070	COG1414	Transcriptional regulator
Arth_4071	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Arth_4073	COG0183	Belongs to the thiolase family
Arth_4074	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Arth_4077	COG3485	protocatechuate 3,4-dioxygenase
Arth_4078	COG3485	protocatechuate 3,4-dioxygenase
Arth_4080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Arth_4081	COG1414	Transcriptional regulator
Arth_4083	COG1793	dna ligase
Arth_4084	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Arth_4085	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Arth_4086	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Arth_4096	COG2814	Major facilitator Superfamily
Arth_4097	COG1937	Protein conserved in bacteria
Arth_4102	COG0697	spore germination
Arth_4107	COG2259	Doxx family
Arth_4109	COG1607	acyl-coa hydrolase
Arth_4110	COG0305	Participates in initiation and elongation during chromosome replication
Arth_4117	COG0359	binds to the 23S rRNA
Arth_4118	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Arth_4120	COG0360	Binds together with S18 to 16S ribosomal RNA
Arth_4122	COG0438	transferase activity, transferring glycosyl groups
Arth_4128	COG1362	aminopeptidase activity
Arth_4133	COG1113	amino acid transport
Arth_4134	COG2197	response regulator
Arth_4135	COG4585	Histidine kinase
Arth_4137	COG1131	(ABC) transporter
Arth_4139	COG0738	Major facilitator superfamily
Arth_4142	COG1620	l-lactate permease
Arth_4144	COG0488	(ABC) transporter
Arth_4145	COG3693	PFAM glycoside hydrolase, family 10
Arth_4147	COG2197	response regulator
Arth_4148	COG3851	Histidine kinase
Arth_4150	COG1136	(ABC) transporter
Arth_4151	COG1733	regulation of RNA biosynthetic process
Arth_4156	COG0406	alpha-ribazole phosphatase activity
Arth_4157	COG0617	tRNA 3'-terminal CCA addition
Arth_4161	COG0492	ferredoxin-NADP+ reductase activity
Arth_4162	COG3118	belongs to the thioredoxin family
Arth_4166	COG1192	Involved in chromosome partitioning
Arth_4167	COG0357	Ribosomal RNA small subunit methyltransferase G
Arth_4169	COG0706	membrane insertase activity
Arth_4170	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Arth_4171	COG0594	ribonuclease P activity
Arth_4172	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Arth_4176	COG1192	Involved in chromosome partitioning
Arth_4189	COG4644	lycopene metabolic process
Arth_4190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Arth_4195	COG0789	Transcriptional regulator
Arth_4200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Arth_4202	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Arth_4204	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Arth_4205	COG2124	cytochrome p450
Arth_4208	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Arth_4209	COG0785	Cytochrome C biogenesis protein
Arth_4255	COG0579	oxidoreductase
Arth_4257	COG1132	(ABC) transporter
Arth_4258	COG1132	(ABC) transporter
Arth_4260	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Arth_4262	COG0640	Transcriptional regulator
Arth_4265	COG0640	Transcriptional regulator
Arth_4269	COG0583	DNA-binding transcription factor activity
Arth_4289	COG4644	lycopene metabolic process
Arth_4290	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Arth_4295	COG0789	Transcriptional regulator
Arth_4300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Arth_4302	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Arth_4304	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Arth_4305	COG2124	cytochrome p450
Arth_4308	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Arth_4309	COG0785	Cytochrome C biogenesis protein
Arth_4313	COG3415	Transposase
Arth_4313	COG2801	Transposase and inactivated derivatives
Arth_4314	COG0489	protein tyrosine kinase activity
Arth_4324	COG2135	peptidase activity
Arth_4332	COG1475	DNA binding
Arth_4341	COG4974	Belongs to the 'phage' integrase family
Arth_4346	COG4638	Rieske (2fe-2S)
Arth_4350	COG1028	Short-chain dehydrogenase reductase Sdr
Arth_4355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Arth_4357	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Arth_4359	COG1335	isochorismatase
Arth_4361	COG0656	L-ascorbic acid biosynthetic process
Arth_4369	COG1414	Transcriptional regulator
Arth_4371	COG0667	Aldo Keto reductase
Arth_4376	COG2159	amidohydrolase
Arth_4377	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Arth_4379	COG0586	Pfam SNARE associated Golgi protein
Arth_4386	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Arth_4393	COG3547	Transposase (IS116 IS110 IS902 family)
Arth_4414	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Arth_4415	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Arth_4421	COG2132	Multicopper oxidase
Arth_4423	COG1742	UPF0060 membrane protein
Arth_4429	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Arth_4432	COG0785	Cytochrome C biogenesis protein
Arth_4433	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Arth_4446	COG3336	cytochrome c oxidase
Arth_4447	COG0640	Transcriptional regulator
Arth_4454	COG1196	nuclear chromosome segregation
Arth_4454	COG0741	lytic transglycosylase activity
Arth_4454	COG0739	heme binding
Arth_4458	COG4644	lycopene metabolic process
Arth_4459	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Arth_4464	COG0789	Transcriptional regulator
Arth_4469	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Arth_4471	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Arth_4473	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Arth_4474	COG2124	cytochrome p450
Arth_4477	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Arth_4478	COG0785	Cytochrome C biogenesis protein
Arth_4482	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Arth_4490	COG2132	Multicopper oxidase
Arth_4491	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Arth_4493	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Arth_4519	COG1192	Involved in chromosome partitioning
Arth_4520	COG4974	Belongs to the 'phage' integrase family
Arth_4522	COG3328	transposase activity
Arth_4526	COG0586	Pfam SNARE associated Golgi protein
Arth_4531	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Arth_4533	COG2205	protein histidine kinase activity
Arth_4535	COG0745	RESPONSE REGULATOR receiver
Arth_4536	COG0671	phosphoesterase, PA-phosphatase related