locus-tag	class	description
LFT45_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LFT45_00010	COG0592	DNA-directed DNA polymerase activity
LFT45_00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LFT45_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LFT45_00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
LFT45_00030	COG0187	DNA topoisomerase II activity
LFT45_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LFT45_00040	COG3266	domain, Protein
LFT45_00065	COG1215	transferase activity, transferring glycosyl groups
LFT45_00080	COG0705	Rhomboid family
LFT45_00085	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LFT45_00090	COG2818	Glycosylase
LFT45_00100	COG3764	Sortase (surface protein transpeptidase)
LFT45_00110	COG0515	serine threonine protein kinase
LFT45_00115	COG0515	serine threonine protein kinase
LFT45_00120	COG0768	penicillin binding
LFT45_00135	COG1716	ATPase activity
LFT45_00150	COG2801	Transposase and inactivated derivatives
LFT45_00150	COG3415	Transposase
LFT45_00165	COG0589	response to stress
LFT45_00170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LFT45_00175	COG0747	negative chemotaxis
LFT45_00185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LFT45_00190	COG0444	Belongs to the ABC transporter superfamily
LFT45_00195	COG4608	Belongs to the ABC transporter superfamily
LFT45_00205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LFT45_00210	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_00215	COG0583	DNA-binding transcription factor activity
LFT45_00220	COG1609	Transcriptional regulator
LFT45_00230	COG2176	DNA-directed DNA polymerase activity
LFT45_00240	COG2508	Transcriptional regulator
LFT45_00275	COG0673	inositol 2-dehydrogenase activity
LFT45_00280	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_00290	COG0477	Major facilitator Superfamily
LFT45_00295	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LFT45_00300	COG1609	Transcriptional regulator
LFT45_00305	COG0673	inositol 2-dehydrogenase activity
LFT45_00310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LFT45_00315	COG0477	Major facilitator Superfamily
LFT45_00320	COG1082	Xylose isomerase domain protein TIM barrel
LFT45_00325	COG1414	Transcriptional regulator
LFT45_00330	COG1175	transmembrane transport
LFT45_00365	COG0149	triose-phosphate isomerase activity
LFT45_00370	COG5564	TIM-barrel signal transduction protein
LFT45_00380	COG0698	ribose 5-phosphate isomerase
LFT45_00385	COG1609	Transcriptional regulator
LFT45_00405	COG0395	ABC-type sugar transport system, permease component
LFT45_00410	COG1609	Transcriptional regulator
LFT45_00415	COG1621	beta-fructofuranosidase activity
LFT45_00440	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT45_00445	COG1129	ABC transporter
LFT45_00455	COG1609	Transcriptional regulator
LFT45_00475	COG1271	oxidase subunit
LFT45_00485	COG0579	oxidoreductase
LFT45_00520	COG0129	dihydroxy-acid dehydratase activity
LFT45_00540	COG0800	Aldolase
LFT45_00545	COG2186	Transcriptional regulator
LFT45_00555	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT45_00560	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT45_00575	COG2376	Dihydroxyacetone kinase
LFT45_00580	COG1461	Dihydroxyacetone kinase
LFT45_00585	COG0693	protein deglycase activity
LFT45_00600	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_00605	COG3386	PFAM SMP-30 Gluconolaconase
LFT45_00620	COG0693	protein deglycase activity
LFT45_00635	COG0673	inositol 2-dehydrogenase activity
LFT45_00645	COG1175	transmembrane transport
LFT45_00655	COG1063	alcohol dehydrogenase
LFT45_00665	COG1940	carbohydrate kinase activity
LFT45_00690	COG1410	methionine synthase
LFT45_00690	COG0646	methionine synthase
LFT45_00695	COG3845	ABC transporter
LFT45_00710	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_00720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LFT45_00725	COG0583	DNA-binding transcription factor activity
LFT45_00745	COG0589	response to stress
LFT45_00770	COG1609	Transcriptional regulator
LFT45_00780	COG0765	amino acid transport
LFT45_00785	COG1126	abc transporter atp-binding protein
LFT45_00790	COG0673	inositol 2-dehydrogenase activity
LFT45_00830	COG2271	Major facilitator Superfamily
LFT45_00840	COG2124	cytochrome p450
LFT45_00845	COG0679	Auxin Efflux Carrier
LFT45_00865	COG0346	lactoylglutathione lyase activity
LFT45_00870	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LFT45_00870	COG1796	DNA polymerase
LFT45_00880	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_00885	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LFT45_00895	COG0601	transmembrane transport
LFT45_00900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LFT45_00905	COG0444	Belongs to the ABC transporter superfamily
LFT45_00910	COG4608	Belongs to the ABC transporter superfamily
LFT45_00915	COG0667	Aldo Keto reductase
LFT45_00935	COG1349	DNA-binding transcription factor activity
LFT45_00950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LFT45_00970	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
LFT45_00985	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LFT45_00990	COG1309	transcriptional regulator
LFT45_00995	COG1846	Transcriptional regulator
LFT45_01000	COG0387	Pfam Sodium calcium exchanger
LFT45_01020	COG3960	tartronate-semialdehyde synthase activity
LFT45_01035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LFT45_01040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LFT45_01100	COG0531	amino acid
LFT45_01120	COG1609	Transcriptional regulator
LFT45_01130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LFT45_01135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_01140	COG0385	Bile acid
LFT45_01145	COG3706	GGDEF domain
LFT45_01155	COG0659	secondary active sulfate transmembrane transporter activity
LFT45_01215	COG1609	Transcriptional regulator
LFT45_01235	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LFT45_01240	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LFT45_01240	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LFT45_01245	COG2084	Dehydrogenase
LFT45_01265	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LFT45_01270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LFT45_01275	COG2971	BadF BadG BcrA BcrD
LFT45_01280	COG2814	Major facilitator Superfamily
LFT45_01285	COG2188	Transcriptional regulator
LFT45_01315	COG1609	Transcriptional regulator
LFT45_01320	COG0477	Major facilitator Superfamily
LFT45_01325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LFT45_01330	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_01335	COG1250	3-hydroxyacyl-CoA dehydrogenase
LFT45_01345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LFT45_01355	COG0509	glycine decarboxylation via glycine cleavage system
LFT45_01360	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LFT45_01365	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LFT45_01365	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LFT45_01370	COG1113	amino acid transport
LFT45_01385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_01390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_01410	COG0765	amino acid transport
LFT45_01435	COG2132	Multicopper oxidase
LFT45_01445	COG1609	Transcriptional regulator
LFT45_01460	COG2160	L-arabinose isomerase activity
LFT45_01465	COG2017	converts alpha-aldose to the beta-anomer
LFT45_01470	COG1609	Transcriptional regulator
LFT45_01485	COG4214	carbohydrate transport
LFT45_01490	COG1129	ABC transporter
LFT45_01495	COG4213	ABC transporter substrate-binding protein
LFT45_01505	COG0697	spore germination
LFT45_01560	COG2814	Major facilitator Superfamily
LFT45_01565	COG1846	Transcriptional regulator
LFT45_01575	COG1175	transmembrane transport
LFT45_01580	COG0395	ABC-type sugar transport system, permease component
LFT45_01600	COG1940	carbohydrate kinase activity
LFT45_01605	COG0277	FAD linked oxidase domain protein
LFT45_01610	COG2115	Belongs to the xylose isomerase family
LFT45_01615	COG1070	Carbohydrate kinase
LFT45_01625	COG0673	inositol 2-dehydrogenase activity
LFT45_01640	COG0673	inositol 2-dehydrogenase activity
LFT45_01650	COG1175	transmembrane transport
LFT45_01655	COG1653	transport
LFT45_01660	COG1609	Transcriptional regulator
LFT45_01680	COG0584	glycerophosphoryl diester phosphodiesterase
LFT45_01695	COG0028	Belongs to the TPP enzyme family
LFT45_01700	COG1929	Belongs to the glycerate kinase type-1 family
LFT45_01710	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_01720	COG2233	PERMEase
LFT45_01725	COG0778	Nitroreductase
LFT45_01750	COG0154	amidase activity
LFT45_01755	COG0425	Belongs to the sulfur carrier protein TusA family
LFT45_01755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LFT45_01770	COG1597	lipid kinase activity
LFT45_01775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LFT45_01780	COG0561	phosphatase activity
LFT45_01795	COG2027	D-alanyl-D-alanine carboxypeptidase
LFT45_01805	COG0037	tRNA processing
LFT45_01815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LFT45_01820	COG0302	gtp cyclohydrolase
LFT45_01825	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LFT45_01830	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LFT45_01860	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LFT45_01865	COG2814	Major facilitator Superfamily
LFT45_01880	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LFT45_01900	COG0823	Involved in the tonB-independent uptake of proteins
LFT45_01900	COG1506	peptidase
LFT45_01905	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LFT45_01910	COG2376	Dihydroxyacetone kinase
LFT45_01915	COG1461	Dihydroxyacetone kinase
LFT45_01920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LFT45_01920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LFT45_01920	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LFT45_01945	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LFT45_01950	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LFT45_01990	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_01995	COG0477	Major facilitator Superfamily
LFT45_02010	COG3971	2-oxopent-4-enoate hydratase activity
LFT45_02025	COG1802	Transcriptional regulator
LFT45_02050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LFT45_02055	COG4977	sequence-specific DNA binding
LFT45_02065	COG3226	Transcriptional regulator
LFT45_02100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LFT45_02105	COG0306	phosphate transporter
LFT45_02130	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LFT45_02135	COG1609	Transcriptional regulator
LFT45_02145	COG0831	urea catabolic process
LFT45_02150	COG0832	Belongs to the urease beta subunit family
LFT45_02155	COG0804	urea catabolic process
LFT45_02160	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LFT45_02165	COG0830	nickel cation binding
LFT45_02170	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LFT45_02175	COG0829	nickel cation binding
LFT45_02180	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LFT45_02185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LFT45_02205	COG1609	Transcriptional regulator
LFT45_02215	COG1621	beta-fructofuranosidase activity
LFT45_02240	COG2890	protein-(glutamine-N5) methyltransferase activity
LFT45_02255	COG2261	transglycosylase associated protein
LFT45_02280	COG0667	Aldo Keto reductase
LFT45_02285	COG0656	L-ascorbic acid biosynthetic process
LFT45_02295	COG3360	Dodecin
LFT45_02300	COG2186	Transcriptional regulator
LFT45_02310	COG2084	Dehydrogenase
LFT45_02345	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LFT45_02360	COG0300	oxidoreductase activity
LFT45_02370	COG0477	Major facilitator Superfamily
LFT45_02390	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LFT45_02410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LFT45_02410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LFT45_02410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LFT45_02415	COG1105	Belongs to the carbohydrate kinase PfkB family
LFT45_02420	COG1349	DNA-binding transcription factor activity
LFT45_02435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LFT45_02460	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LFT45_02470	COG2733	membrane
LFT45_02510	COG4122	O-methyltransferase activity
LFT45_02520	COG2132	Multicopper oxidase
LFT45_02530	COG0783	Belongs to the Dps family
LFT45_02540	COG1295	ribonuclease BN
LFT45_02560	COG1191	sigma factor activity
LFT45_02565	COG0859	PFAM glycosyl transferase family 9
LFT45_02570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LFT45_02575	COG0859	PFAM glycosyl transferase family 9
LFT45_02585	COG0438	transferase activity, transferring glycosyl groups
LFT45_02590	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LFT45_02595	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LFT45_02595	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LFT45_02610	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_02615	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LFT45_02615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LFT45_02625	COG0583	DNA-binding transcription factor activity
LFT45_02630	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_02635	COG1280	lysine exporter protein (LysE YggA)
LFT45_02655	COG4221	oxidoreductase activity
LFT45_02665	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LFT45_02690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LFT45_02695	COG0010	Belongs to the arginase family
LFT45_02700	COG2252	PERMEase
LFT45_02720	COG3848	Pyruvate phosphate dikinase
LFT45_02720	COG0574	Belongs to the PEP-utilizing enzyme family
LFT45_02760	COG0697	spore germination
LFT45_02790	COG1302	Protein conserved in bacteria
LFT45_02820	COG2182	Extracellular solute-binding protein
LFT45_02840	COG1609	Transcriptional regulator
LFT45_02860	COG1024	Enoyl-CoA hydratase
LFT45_02905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LFT45_02910	COG1960	acyl-CoA dehydrogenase activity
LFT45_02915	COG2318	DinB family
LFT45_02920	COG1278	Cold shock
LFT45_02930	COG2197	response regulator
LFT45_02935	COG4585	Histidine kinase
LFT45_02945	COG0666	response to abiotic stimulus
LFT45_02955	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LFT45_02970	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LFT45_02975	COG1609	Transcriptional regulator
LFT45_02985	COG0673	inositol 2-dehydrogenase activity
LFT45_02990	COG0747	negative chemotaxis
LFT45_03000	COG0444	Belongs to the ABC transporter superfamily
LFT45_03015	COG0673	inositol 2-dehydrogenase activity
LFT45_03020	COG1609	Transcriptional regulator
LFT45_03025	COG1904	glucuronate isomerase
LFT45_03030	COG0246	Mannitol dehydrogenase
LFT45_03035	COG3250	beta-galactosidase activity
LFT45_03045	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_03050	COG3265	gluconokinase activity
LFT45_03060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LFT45_03105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LFT45_03125	COG1832	CoA-binding protein
LFT45_03140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LFT45_03145	COG1832	CoA-binding protein
LFT45_03155	COG2315	Protein conserved in bacteria
LFT45_03160	COG4762	Protein conserved in bacteria
LFT45_03180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LFT45_03185	COG0047	phosphoribosylformylglycinamidine synthase activity
LFT45_03200	COG1404	Belongs to the peptidase S8 family
LFT45_03225	COG1846	Transcriptional regulator
LFT45_03245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LFT45_03260	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LFT45_03275	COG0739	heme binding
LFT45_03275	COG0741	lytic transglycosylase activity
LFT45_03275	COG1196	nuclear chromosome segregation
LFT45_03280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LFT45_03285	COG0438	transferase activity, transferring glycosyl groups
LFT45_03315	COG0438	transferase activity, transferring glycosyl groups
LFT45_03325	COG0673	inositol 2-dehydrogenase activity
LFT45_03330	COG0673	inositol 2-dehydrogenase activity
LFT45_03340	COG1940	carbohydrate kinase activity
LFT45_03345	COG0673	inositol 2-dehydrogenase activity
LFT45_03360	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LFT45_03370	COG1476	TRANSCRIPTIONal
LFT45_03380	COG0028	Belongs to the TPP enzyme family
LFT45_03395	COG0351	phosphomethylpyrimidine kinase
LFT45_03400	COG0477	Major facilitator Superfamily
LFT45_03415	COG0343	queuine tRNA-ribosyltransferase activity
LFT45_03445	COG1621	beta-fructofuranosidase activity
LFT45_03450	COG3842	ATPase activity
LFT45_03475	COG1960	acyl-CoA dehydrogenase activity
LFT45_03490	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LFT45_03495	COG1120	ATPase activity
LFT45_03500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LFT45_03505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LFT45_03575	COG0586	Pfam SNARE associated Golgi protein
LFT45_03585	COG0564	pseudouridine synthase activity
LFT45_03600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LFT45_03605	COG2364	Membrane
LFT45_03610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LFT45_03615	COG1201	RNA secondary structure unwinding
LFT45_03620	COG0723	plastoquinol--plastocyanin reductase activity
LFT45_03630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LFT45_03640	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LFT45_03680	COG0438	transferase activity, transferring glycosyl groups
LFT45_03695	COG0671	phosphoesterase, PA-phosphatase related
LFT45_03700	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LFT45_03730	COG2205	protein histidine kinase activity
LFT45_03735	COG0745	RESPONSE REGULATOR receiver
LFT45_03750	COG2062	phosphohistidine phosphatase, SixA
LFT45_03760	COG1309	transcriptional regulator
LFT45_03765	COG1511	domain protein
LFT45_03780	COG1802	Transcriptional regulator
LFT45_03790	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LFT45_03795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LFT45_03795	COG1017	nitric oxide dioxygenase activity
LFT45_03810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LFT45_03815	COG0514	ATP-dependent DNA helicase (RecQ)
LFT45_03820	COG2814	Major facilitator Superfamily
LFT45_03825	COG2801	Transposase and inactivated derivatives
LFT45_03825	COG3415	Transposase
LFT45_03835	COG1505	serine-type exopeptidase activity
LFT45_03855	COG0604	alcohol dehydrogenase
LFT45_03865	COG1136	(ABC) transporter
LFT45_03865	COG0577	efflux transmembrane transporter activity
LFT45_03875	COG1966	Carbon starvation protein
LFT45_03900	COG0656	L-ascorbic acid biosynthetic process
LFT45_03920	COG2261	transglycosylase associated protein
LFT45_03945	COG3655	Transcriptional regulator
LFT45_03990	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LFT45_03995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LFT45_04015	COG0588	phosphoglycerate mutase activity
LFT45_04025	COG5002	protein histidine kinase activity
LFT45_04045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LFT45_04050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LFT45_04060	COG0215	cysteine-tRNA ligase activity
LFT45_04095	COG0366	Alpha amylase catalytic
LFT45_04105	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LFT45_04125	COG1280	lysine exporter protein (LysE YggA)
LFT45_04130	COG2826	transposase and inactivated derivatives, IS30 family
LFT45_04140	COG1609	Transcriptional regulator
LFT45_04145	COG0366	Alpha amylase catalytic
LFT45_04150	COG0277	FAD linked oxidase domain protein
LFT45_04155	COG0402	S-adenosylhomocysteine deaminase activity
LFT45_04165	COG3842	ATPase activity
LFT45_04320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LFT45_04365	COG0318	PFAM AMP-dependent synthetase and ligase
LFT45_04375	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LFT45_04380	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LFT45_04390	COG2079	MmgE PrpD family protein
LFT45_04395	COG0028	Belongs to the TPP enzyme family
LFT45_04405	COG0183	Belongs to the thiolase family
LFT45_04460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LFT45_04465	COG1063	alcohol dehydrogenase
LFT45_04485	COG1129	ABC transporter
LFT45_04500	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_04530	COG1414	Transcriptional regulator
LFT45_04540	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LFT45_04555	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LFT45_04565	COG1414	Transcriptional regulator
LFT45_04585	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LFT45_04590	COG2079	MmgE PrpD family protein
LFT45_04605	COG1879	ABC-type sugar transport system periplasmic component
LFT45_04610	COG1129	ABC transporter
LFT45_04615	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT45_04620	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_04645	COG3547	Transposase (IS116 IS110 IS902 family)
LFT45_04665	COG0535	radical SAM domain protein
LFT45_04695	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LFT45_04715	COG0667	Aldo Keto reductase
LFT45_04720	COG3964	amidohydrolase
LFT45_04725	COG0567	Dehydrogenase, E1 component
LFT45_04730	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_04750	COG1960	acyl-CoA dehydrogenase activity
LFT45_04770	COG2851	Citrate transporter
LFT45_04775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LFT45_04780	COG2301	Belongs to the HpcH HpaI aldolase family
LFT45_04805	COG0583	DNA-binding transcription factor activity
LFT45_04815	COG1063	alcohol dehydrogenase
LFT45_04820	COG0583	DNA-binding transcription factor activity
LFT45_04825	COG1063	alcohol dehydrogenase
LFT45_04830	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_04850	COG1129	ABC transporter
LFT45_04860	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_04865	COG2301	Belongs to the HpcH HpaI aldolase family
LFT45_04870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LFT45_04880	COG0477	Major facilitator Superfamily
LFT45_04895	COG0277	FAD linked oxidase domain protein
LFT45_04895	COG0247	lactate metabolic process
LFT45_04900	COG2271	Major facilitator Superfamily
LFT45_04910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LFT45_04915	COG0121	glutamine amidotransferase
LFT45_04925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LFT45_04935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LFT45_04945	COG2271	Major facilitator Superfamily
LFT45_04970	COG2957	Belongs to the agmatine deiminase family
LFT45_04975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LFT45_04980	COG0783	Belongs to the Dps family
LFT45_04985	COG0477	Major facilitator Superfamily
LFT45_04995	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LFT45_04995	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LFT45_05000	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LFT45_05005	COG0509	glycine decarboxylation via glycine cleavage system
LFT45_05010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LFT45_05020	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
LFT45_05040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LFT45_05065	COG0459	protein refolding
LFT45_05070	COG0328	RNA-DNA hybrid ribonuclease activity
LFT45_05080	COG2205	protein histidine kinase activity
LFT45_05085	COG0745	RESPONSE REGULATOR receiver
LFT45_05090	COG1061	Type III restriction enzyme res subunit
LFT45_05105	COG1278	Cold shock
LFT45_05125	COG0739	heme binding
LFT45_05130	COG0791	NLP P60 protein
LFT45_05130	COG1388	LysM domain
LFT45_05130	COG3103	Sh3 type 3 domain protein
LFT45_05135	COG1388	LysM domain
LFT45_05135	COG3103	Sh3 type 3 domain protein
LFT45_05135	COG0791	NLP P60 protein
LFT45_05145	COG0746	molybdenum cofactor guanylyltransferase activity
LFT45_05160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LFT45_05170	COG1126	abc transporter atp-binding protein
LFT45_05175	COG0765	amino acid transport
LFT45_05180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LFT45_05205	COG0488	(ABC) transporter
LFT45_05210	COG1132	(ABC) transporter
LFT45_05220	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LFT45_05245	COG0483	inositol monophosphate 1-phosphatase activity
LFT45_05260	COG0045	succinate-CoA ligase (ADP-forming) activity
LFT45_05275	COG1942	4-Oxalocrotonate Tautomerase
LFT45_05280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LFT45_05290	COG3962	Belongs to the TPP enzyme family
LFT45_05305	COG0673	inositol 2-dehydrogenase activity
LFT45_05310	COG1082	Xylose isomerase domain protein TIM barrel
LFT45_05315	COG2814	Major facilitator Superfamily
LFT45_05325	COG2814	Major facilitator Superfamily
LFT45_05330	COG3718	enzyme involved in inositol metabolism
LFT45_05335	COG2188	Transcriptional regulator
LFT45_05340	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LFT45_05350	COG2186	Transcriptional regulator
LFT45_05360	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_05390	COG1396	sequence-specific DNA binding
LFT45_05400	COG0028	Belongs to the TPP enzyme family
LFT45_05435	COG1401	restriction endodeoxyribonuclease activity
LFT45_05445	COG1309	transcriptional regulator
LFT45_05450	COG5002	protein histidine kinase activity
LFT45_05455	COG0745	RESPONSE REGULATOR receiver
LFT45_05490	COG1902	pentaerythritol trinitrate reductase activity
LFT45_05505	COG2376	Dihydroxyacetone kinase
LFT45_05510	COG0698	ribose 5-phosphate isomerase
LFT45_05515	COG1250	3-hydroxyacyl-CoA dehydrogenase
LFT45_05520	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_05525	COG2271	Major facilitator Superfamily
LFT45_05530	COG0149	triose-phosphate isomerase activity
LFT45_05585	COG3583	domain protein
LFT45_05595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LFT45_05610	COG0667	Aldo Keto reductase
LFT45_05615	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_05630	COG3103	Sh3 type 3 domain protein
LFT45_05630	COG0366	Alpha amylase catalytic
LFT45_05645	COG1254	Belongs to the acylphosphatase family
LFT45_05660	COG1063	alcohol dehydrogenase
LFT45_05675	COG2353	YceI-like domain
LFT45_05700	COG0246	Mannitol dehydrogenase
LFT45_05705	COG0800	Aldolase
LFT45_05725	COG0640	Transcriptional regulator
LFT45_05735	COG0514	ATP-dependent DNA helicase (RecQ)
LFT45_05755	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_05760	COG1063	alcohol dehydrogenase
LFT45_05790	COG0300	oxidoreductase activity
LFT45_05810	COG0477	Major facilitator Superfamily
LFT45_05850	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LFT45_05880	COG2828	Protein conserved in bacteria
LFT45_05915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LFT45_05920	COG0531	amino acid
LFT45_05925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LFT45_05935	COG0477	Major facilitator Superfamily
LFT45_05970	COG0477	Major facilitator Superfamily
LFT45_06075	COG0328	RNA-DNA hybrid ribonuclease activity
LFT45_06110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LFT45_06140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LFT45_06145	COG0477	Major facilitator Superfamily
LFT45_06175	COG2186	Transcriptional regulator
LFT45_06185	COG1070	Carbohydrate kinase
LFT45_06205	COG0395	ABC-type sugar transport system, permease component
LFT45_06210	COG1063	alcohol dehydrogenase
LFT45_06225	COG2337	Toxic component of a toxin-antitoxin (TA) module
LFT45_06235	COG3328	transposase activity
LFT45_06255	COG4942	peptidase
LFT45_06260	COG1733	regulation of RNA biosynthetic process
LFT45_06270	COG3708	Transcriptional regulator
LFT45_06270	COG2207	Transcriptional regulator
LFT45_06295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LFT45_06300	COG1113	amino acid transport
LFT45_06325	COG1215	transferase activity, transferring glycosyl groups
LFT45_06335	COG3387	PFAM Glycoside hydrolase 15-related
LFT45_06345	COG2072	flavoprotein involved in K transport
LFT45_06360	COG1914	H( )-stimulated, divalent metal cation uptake system
LFT45_06375	COG1278	Cold shock
LFT45_06395	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LFT45_06405	COG3265	gluconokinase activity
LFT45_06410	COG2610	gluconate transmembrane transporter activity
LFT45_06425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LFT45_06470	COG0515	serine threonine protein kinase
LFT45_06470	COG2815	serine threonine protein kinase
LFT45_06510	COG5001	Diguanylate cyclase
LFT45_06510	COG3300	MHYT domain
LFT45_06515	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LFT45_06530	COG2268	Band 7 protein
LFT45_06560	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
LFT45_06605	COG0477	Major facilitator Superfamily
LFT45_06610	COG0138	bifunctional purine biosynthesis protein purh
LFT45_06625	COG2838	Isocitrate dehydrogenase
LFT45_06645	COG0515	serine threonine protein kinase
LFT45_06660	COG0673	inositol 2-dehydrogenase activity
LFT45_06665	COG1136	(ABC) transporter
LFT45_06675	COG4213	ABC transporter substrate-binding protein
LFT45_06680	COG4214	carbohydrate transport
LFT45_06705	COG0531	amino acid
LFT45_06725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LFT45_06745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LFT45_06750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LFT45_06755	COG4585	Histidine kinase
LFT45_06760	COG2197	response regulator
LFT45_06795	COG0180	Tryptophanyl-tRNA synthetase
LFT45_06815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LFT45_06830	COG2009	succinate dehydrogenase
LFT45_06840	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LFT45_06840	COG1473	amidohydrolase
LFT45_06845	COG1846	Transcriptional regulator
LFT45_06850	COG1764	response to oxidative stress
LFT45_06855	COG2130	NADP-dependent
LFT45_06875	COG0586	Pfam SNARE associated Golgi protein
LFT45_06880	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LFT45_06885	COG3956	TIGRFAM MazG family protein
LFT45_06890	COG0148	phosphopyruvate hydratase activity
LFT45_06915	COG1252	NADH dehydrogenase
LFT45_06950	COG0559	Belongs to the binding-protein-dependent transport system permease family
LFT45_06960	COG2826	transposase and inactivated derivatives, IS30 family
LFT45_06965	COG0183	Belongs to the thiolase family
LFT45_06970	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LFT45_06980	COG1349	DNA-binding transcription factor activity
LFT45_06985	COG2017	converts alpha-aldose to the beta-anomer
LFT45_06995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LFT45_07005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LFT45_07015	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LFT45_07025	COG1331	Highly conserved protein containing a thioredoxin domain
LFT45_07035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LFT45_07040	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LFT45_07090	COG0765	amino acid transport
LFT45_07095	COG1126	abc transporter atp-binding protein
LFT45_07100	COG0251	oxidation-reduction process
LFT45_07105	COG0114	fumarate hydratase activity
LFT45_07110	COG0288	reversible hydration of carbon dioxide
LFT45_07120	COG1494	fructose-1,6-bisphosphatase
LFT45_07135	COG1482	cell wall glycoprotein biosynthetic process
LFT45_07145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LFT45_07195	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LFT45_07200	COG1376	ErfK ybiS ycfS ynhG family protein
LFT45_07240	COG0477	Major facilitator Superfamily
LFT45_07255	COG0714	Associated with various cellular activities
LFT45_07260	COG0084	hydrolase, TatD family'
LFT45_07265	COG3583	domain protein
LFT45_07270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LFT45_07275	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LFT45_07280	COG0488	(ABC) transporter
LFT45_07285	COG1309	transcriptional regulator
LFT45_07295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LFT45_07305	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LFT45_07310	COG0193	aminoacyl-tRNA hydrolase activity
LFT45_07330	COG0822	iron-sulfur transferase activity
LFT45_07335	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LFT45_07350	COG0702	epimerase
LFT45_07370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LFT45_07385	COG1648	precorrin-2 dehydrogenase activity
LFT45_07385	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LFT45_07390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LFT45_07400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LFT45_07405	COG1959	2 iron, 2 sulfur cluster binding
LFT45_07435	COG0243	molybdopterin cofactor binding
LFT45_07440	COG2223	nitrite transmembrane transporter activity
LFT45_07445	COG0477	Major facilitator Superfamily
LFT45_07450	COG4770	biotin carboxylase activity
LFT45_07455	COG0424	maF-like protein
LFT45_07460	COG2409	Drug exporters of the RND superfamily
LFT45_07475	COG0596	Alpha beta hydrolase
LFT45_07480	COG1823	symporter activity
LFT45_07495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LFT45_07500	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_07505	COG0640	Transcriptional regulator
LFT45_07515	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LFT45_07515	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LFT45_07535	COG0714	Associated with various cellular activities
LFT45_07555	COG0631	protein serine/threonine phosphatase activity
LFT45_07575	COG1674	ftsk spoiiie
LFT45_07590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LFT45_07595	COG0483	inositol monophosphate 1-phosphatase activity
LFT45_07610	COG0251	oxidation-reduction process
LFT45_07620	COG4565	transcriptional regulatory protein
LFT45_07630	COG2851	Citrate transporter
LFT45_07635	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LFT45_07640	COG0154	amidase activity
LFT45_07645	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LFT45_07650	COG0583	DNA-binding transcription factor activity
LFT45_07655	COG1063	alcohol dehydrogenase
LFT45_07660	COG0156	8-amino-7-oxononanoate synthase activity
LFT45_07670	COG1228	amidohydrolase
LFT45_07680	COG0588	phosphoglycerate mutase activity
LFT45_07695	COG2873	o-acetylhomoserine
LFT45_07700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LFT45_07740	COG0400	carboxylic ester hydrolase activity
LFT45_07755	COG0423	glycine-tRNA ligase activity
LFT45_07795	COG0358	DNA primase activity
LFT45_07820	COG2814	Major facilitator Superfamily
LFT45_07830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LFT45_07840	COG0438	transferase activity, transferring glycosyl groups
LFT45_07865	COG0052	Belongs to the universal ribosomal protein uS2 family
LFT45_07870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LFT45_07875	COG0528	UMP kinase activity
LFT45_07880	COG0233	cytoplasmic translational termination
LFT45_07895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LFT45_07910	COG3275	phosphorelay sensor kinase activity
LFT45_07920	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LFT45_07940	COG1522	sequence-specific DNA binding
LFT45_07950	COG0022	dehydrogenase e1 component
LFT45_07955	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT45_07965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LFT45_07975	COG1960	acyl-CoA dehydrogenase activity
LFT45_08005	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LFT45_08010	COG0750	zinc metalloprotease
LFT45_08030	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LFT45_08040	COG0442	prolyl-tRNA aminoacylation
LFT45_08055	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
LFT45_08070	COG0779	Required for maturation of 30S ribosomal subunits
LFT45_08085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LFT45_08090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LFT45_08115	COG0590	tRNA wobble adenosine to inosine editing
LFT45_08120	COG0436	Aminotransferase
LFT45_08125	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LFT45_08150	COG3483	tryptophan 2,3-dioxygenase activity
LFT45_08160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LFT45_08165	COG1185	polyribonucleotide nucleotidyltransferase activity
LFT45_08170	COG0612	Peptidase, M16
LFT45_08210	COG0521	Mo-molybdopterin cofactor biosynthetic process
LFT45_08220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LFT45_08235	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LFT45_08265	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LFT45_08270	COG1674	ftsk spoiiie
LFT45_08280	COG1058	Belongs to the CinA family
LFT45_08280	COG1546	Belongs to the CinA family
LFT45_08285	COG1396	sequence-specific DNA binding
LFT45_08300	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LFT45_08305	COG2137	regulation of response to DNA damage stimulus
LFT45_08310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LFT45_08315	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LFT45_08320	COG0697	spore germination
LFT45_08325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LFT45_08330	COG2813	Specifically methylates the guanine in position
LFT45_08335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LFT45_08345	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LFT45_08355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LFT45_08360	COG0131	Imidazoleglycerol-phosphate dehydratase
LFT45_08365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LFT45_08375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LFT45_08395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LFT45_08400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LFT45_08405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LFT45_08410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LFT45_08425	COG2814	Major facilitator Superfamily
LFT45_08435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LFT45_08440	COG2011	ABC-type metal ion transport system permease component
LFT45_08445	COG1464	Belongs to the NlpA lipoprotein family
LFT45_08455	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LFT45_08470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LFT45_08475	COG0072	phenylalanine-tRNA ligase activity
LFT45_08475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LFT45_08480	COG0464	growth
LFT45_08505	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LFT45_08510	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LFT45_08515	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LFT45_08520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LFT45_08525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LFT45_08530	COG1438	arginine binding
LFT45_08535	COG0137	argininosuccinate synthase activity
LFT45_08540	COG0165	Argininosuccinate lyase
LFT45_08550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LFT45_08550	COG2169	Transcriptional regulator
LFT45_08560	COG2094	Belongs to the DNA glycosylase MPG family
LFT45_08565	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LFT45_08575	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LFT45_08600	COG2372	response to copper ion
LFT45_08600	COG1276	copper resistance
LFT45_08615	COG0647	UMP catabolic process
LFT45_08630	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LFT45_08635	COG0497	DNA recombination
LFT45_08640	COG0504	CTP synthase activity
LFT45_08675	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LFT45_08680	COG2079	MmgE PrpD family protein
LFT45_08700	COG3290	protein histidine kinase activity
LFT45_08705	COG1301	dicarboxylic acid transport
LFT45_08715	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LFT45_08720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LFT45_08735	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LFT45_08745	COG1160	GTP binding
LFT45_08755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LFT45_08760	COG0509	glycine decarboxylation via glycine cleavage system
LFT45_08765	COG1716	ATPase activity
LFT45_08790	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LFT45_08805	COG1940	carbohydrate kinase activity
LFT45_08830	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LFT45_08835	COG2815	serine threonine protein kinase
LFT45_08835	COG0515	serine threonine protein kinase
LFT45_08840	COG3942	CHAP domain
LFT45_08840	COG1388	LysM domain
LFT45_08850	COG0142	geranyltranstransferase activity
LFT45_08860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LFT45_08870	COG2001	Belongs to the MraZ family
LFT45_08875	COG0275	rRNA processing
LFT45_08885	COG0768	penicillin binding
LFT45_08895	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LFT45_08900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LFT45_08905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LFT45_08915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LFT45_08920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LFT45_08930	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LFT45_08940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LFT45_08945	COG1799	cell septum assembly
LFT45_08960	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LFT45_08970	COG0587	DNA-directed DNA polymerase activity
LFT45_08985	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LFT45_08990	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LFT45_09010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LFT45_09015	COG0174	glutamine synthetase
LFT45_09020	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LFT45_09060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LFT45_09065	COG0321	lipoyl(octanoyl) transferase activity
LFT45_09075	COG1090	epimerase
LFT45_09080	COG4946	Tricorn protease homolog
LFT45_09080	COG0793	Belongs to the peptidase S41A family
LFT45_09085	COG1764	response to oxidative stress
LFT45_09095	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT45_09100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LFT45_09105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LFT45_09125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LFT45_09155	COG1271	oxidase subunit
LFT45_09160	COG1294	oxidase, subunit
LFT45_09165	COG4988	ABC transporter
LFT45_09170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LFT45_09190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LFT45_09195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LFT45_09195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LFT45_09210	COG1435	thymidine kinase activity
LFT45_09230	COG0756	dUTP diphosphatase activity
LFT45_09255	COG0569	domain protein
LFT45_09260	COG0531	amino acid
LFT45_09265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LFT45_09270	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LFT45_09275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LFT45_09295	COG0667	Aldo Keto reductase
LFT45_09315	COG1122	ATPase activity
LFT45_09320	COG1250	3-hydroxyacyl-CoA dehydrogenase
LFT45_09320	COG1024	Enoyl-CoA hydratase
LFT45_09330	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LFT45_09335	COG2837	iron assimilation
LFT45_09345	COG0672	)-iron permease
LFT45_09370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LFT45_09385	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LFT45_09445	COG0242	peptide deformylase activity
LFT45_09450	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LFT45_09460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LFT45_09480	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LFT45_09480	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LFT45_09485	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LFT45_09485	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LFT45_09490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LFT45_09495	COG0140	phosphoribosyl-ATP diphosphatase activity
LFT45_09500	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LFT45_09505	COG0107	imidazoleglycerol-phosphate synthase activity
LFT45_09515	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LFT45_09535	COG0134	indole-3-glycerol-phosphate synthase activity
LFT45_09540	COG0133	tryptophan synthase activity
LFT45_09545	COG0159	tryptophan synthase activity
LFT45_09550	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LFT45_09555	COG0070	glutamate synthase
LFT45_09555	COG0069	glutamate synthase activity
LFT45_09555	COG0067	glutamate synthase
LFT45_09670	COG1196	nuclear chromosome segregation
LFT45_09705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LFT45_09715	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_09720	COG3119	arylsulfatase activity
LFT45_09725	COG2271	Major facilitator Superfamily
LFT45_09740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LFT45_09775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_09780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_09790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_09830	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LFT45_09845	COG1846	Transcriptional regulator
LFT45_09855	COG3654	unkown
LFT45_09995	COG2026	Addiction module toxin, RelE StbE family
LFT45_10000	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LFT45_10005	COG1131	(ABC) transporter
LFT45_10010	COG3559	Exporter of polyketide antibiotics
LFT45_10020	COG2132	Multicopper oxidase
LFT45_10035	COG2814	Major facilitator Superfamily
LFT45_10045	COG1349	DNA-binding transcription factor activity
LFT45_10050	COG1063	alcohol dehydrogenase
LFT45_10060	COG1129	ABC transporter
LFT45_10065	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT45_10070	COG1879	ABC-type sugar transport system periplasmic component
LFT45_10095	COG2319	Wd-40 repeat
LFT45_10095	COG4249	Peptidase C14 caspase catalytic subunit p20
LFT45_10115	COG3328	transposase activity
LFT45_10120	COG3547	Transposase (IS116 IS110 IS902 family)
LFT45_10130	COG3485	protocatechuate 3,4-dioxygenase
LFT45_10135	COG4638	Rieske (2fe-2S)
LFT45_10140	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LFT45_10170	COG0583	DNA-binding transcription factor activity
LFT45_10175	COG2814	Major facilitator Superfamily
LFT45_10195	COG3387	PFAM Glycoside hydrolase 15-related
LFT45_10215	COG1063	alcohol dehydrogenase
LFT45_10280	COG1802	Transcriptional regulator
LFT45_10285	COG0477	Major facilitator Superfamily
LFT45_10325	COG3321	synthase
LFT45_10325	COG0604	alcohol dehydrogenase
LFT45_10330	COG2267	carboxylic ester hydrolase activity
LFT45_10340	COG2826	transposase and inactivated derivatives, IS30 family
LFT45_10355	COG3328	transposase activity
LFT45_10360	COG2814	Major facilitator Superfamily
LFT45_10365	COG0745	RESPONSE REGULATOR receiver
LFT45_10370	COG5002	protein histidine kinase activity
LFT45_10435	COG0583	DNA-binding transcription factor activity
LFT45_10450	COG0251	oxidation-reduction process
LFT45_10480	COG2814	Major facilitator Superfamily
LFT45_10495	COG4249	Peptidase C14 caspase catalytic subunit p20
LFT45_10495	COG2319	Wd-40 repeat
LFT45_10550	COG4638	Rieske (2fe-2S)
LFT45_10555	COG0583	DNA-binding transcription factor activity
LFT45_10565	COG2201	protein-glutamate methylesterase activity
LFT45_10575	COG3621	Patatin-like phospholipase
LFT45_10585	COG0842	Transport permease protein
LFT45_10585	COG1716	ATPase activity
LFT45_10585	COG1131	(ABC) transporter
LFT45_10605	COG3387	PFAM Glycoside hydrolase 15-related
LFT45_10610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LFT45_10655	COG1619	proteins homologs of microcin C7 resistance protein MccF
LFT45_10680	COG0604	alcohol dehydrogenase
LFT45_10680	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_10680	COG3321	synthase
LFT45_10685	COG1793	dna ligase
LFT45_10720	COG0709	Synthesizes selenophosphate from selenide and ATP
LFT45_10730	COG0437	4 iron, 4 sulfur cluster binding
LFT45_10740	COG0492	ferredoxin-NADP+ reductase activity
LFT45_10745	COG0596	Alpha beta hydrolase
LFT45_10765	COG1252	NADH dehydrogenase
LFT45_10775	COG2814	Major facilitator Superfamily
LFT45_10800	COG1879	ABC-type sugar transport system periplasmic component
LFT45_10810	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT45_10815	COG1129	ABC transporter
LFT45_10820	COG1802	Transcriptional regulator
LFT45_10830	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_10840	COG0506	proline dehydrogenase activity
LFT45_10850	COG0765	amino acid transport
LFT45_10855	COG0765	amino acid transport
LFT45_10865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LFT45_10875	COG0583	DNA-binding transcription factor activity
LFT45_10910	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LFT45_10915	COG2124	cytochrome p450
LFT45_10920	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LFT45_10925	COG0156	8-amino-7-oxononanoate synthase activity
LFT45_10930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LFT45_10940	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LFT45_10985	COG0174	glutamine synthetase
LFT45_11000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LFT45_11015	COG0405	Gamma-glutamyltransferase
LFT45_11035	COG1752	Esterase of the alpha-beta hydrolase superfamily
LFT45_11035	COG1752	Esterase of the alpha-beta hydrolase superfamily
LFT45_11055	COG1643	Atp-dependent helicase
LFT45_11060	COG0438	transferase activity, transferring glycosyl groups
LFT45_11090	COG0009	L-threonylcarbamoyladenylate synthase
LFT45_11140	COG2050	protein possibly involved in aromatic compounds catabolism
LFT45_11155	COG0539	negative regulation of cytoplasmic translation
LFT45_11160	COG0693	protein deglycase activity
LFT45_11165	COG1739	Uncharacterized protein family UPF0029
LFT45_11170	COG0237	dephospho-CoA kinase activity
LFT45_11170	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LFT45_11175	COG0556	nucleotide-excision repair
LFT45_11205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LFT45_11220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LFT45_11235	COG4106	trans-aconitate 2-methyltransferase activity
LFT45_11270	COG0322	excinuclease ABC activity
LFT45_11275	COG1660	Displays ATPase and GTPase activities
LFT45_11280	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LFT45_11285	COG1481	regulation of sporulation
LFT45_11290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LFT45_11295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LFT45_11300	COG0126	phosphoglycerate kinase activity
LFT45_11305	COG0149	triose-phosphate isomerase activity
LFT45_11310	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LFT45_11320	COG0363	glucosamine-6-phosphate deaminase activity
LFT45_11335	COG0166	Belongs to the GPI family
LFT45_11340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LFT45_11350	COG0109	protoheme IX farnesyltransferase activity
LFT45_11355	COG1612	heme a metabolic process
LFT45_11365	COG1131	(ABC) transporter
LFT45_11380	COG0719	Fe-S assembly protein
LFT45_11390	COG0396	ATPase activity
LFT45_11395	COG2151	metal-sulfur cluster biosynthetic enzyme
LFT45_11405	COG0318	PFAM AMP-dependent synthetase and ligase
LFT45_11410	COG0183	Belongs to the thiolase family
LFT45_11425	COG2267	carboxylic ester hydrolase activity
LFT45_11500	COG1122	ATPase activity
LFT45_11505	COG1268	BioY protein
LFT45_11510	COG0488	(ABC) transporter
LFT45_11520	COG1357	PFAM Pentapeptide repeats (8 copies)
LFT45_11550	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_11555	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_11565	COG0560	Phosphoserine phosphatase
LFT45_11565	COG3830	Belongs to the UPF0237 family
LFT45_11570	COG0671	phosphoesterase, PA-phosphatase related
LFT45_11575	COG0477	Major facilitator Superfamily
LFT45_11590	COG1119	ATPase activity
LFT45_11605	COG0254	rRNA binding
LFT45_11620	COG2855	membrane
LFT45_11625	COG2308	Evidence 4 Homologs of previously reported genes of
LFT45_11655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LFT45_11660	COG0297	glycogen (starch) synthase activity
LFT45_11670	COG1309	transcriptional regulator
LFT45_11680	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_11695	COG0435	Glutathione S-transferase
LFT45_11720	COG1929	Belongs to the glycerate kinase type-1 family
LFT45_11725	COG1301	dicarboxylic acid transport
LFT45_11735	COG0583	DNA-binding transcription factor activity
LFT45_11780	COG2801	Transposase and inactivated derivatives
LFT45_11810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LFT45_11830	COG0656	L-ascorbic acid biosynthetic process
LFT45_11835	COG1968	undecaprenyl-diphosphatase activity
LFT45_11840	COG0215	cysteine-tRNA ligase activity
LFT45_11850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LFT45_11855	COG0517	IMP dehydrogenase activity
LFT45_11855	COG1994	Peptidase M50
LFT45_11865	COG1222	aaa ATPase
LFT45_11870	COG4122	O-methyltransferase activity
LFT45_11880	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LFT45_11885	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LFT45_11890	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LFT45_11895	COG0545	Peptidyl-prolyl cis-trans isomerase
LFT45_11915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LFT45_11920	COG0805	protein transport
LFT45_11925	COG4581	dead DEAH box helicase
LFT45_11930	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LFT45_11935	COG1216	Glycosyl transferase, family 2
LFT45_11960	COG4946	Tricorn protease homolog
LFT45_11960	COG1506	peptidase
LFT45_11960	COG0823	Involved in the tonB-independent uptake of proteins
LFT45_11965	COG0242	peptide deformylase activity
LFT45_11970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LFT45_11975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LFT45_11980	COG3424	synthase
LFT45_11995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LFT45_12015	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LFT45_12035	COG2066	Belongs to the glutaminase family
LFT45_12045	COG0028	Belongs to the TPP enzyme family
LFT45_12050	COG1280	lysine exporter protein (LysE YggA)
LFT45_12070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LFT45_12075	COG1845	cytochrome c oxidase, subunit III
LFT45_12080	COG2010	Cytochrome c
LFT45_12085	COG0723	plastoquinol--plastocyanin reductase activity
LFT45_12090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LFT45_12095	COG2188	Transcriptional regulator
LFT45_12100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LFT45_12110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LFT45_12115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LFT45_12135	COG0167	dihydroorotate dehydrogenase activity
LFT45_12145	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LFT45_12150	COG1381	Involved in DNA repair and RecF pathway recombination
LFT45_12155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LFT45_12160	COG3590	peptidase
LFT45_12165	COG1316	TRANSCRIPTIONal
LFT45_12170	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LFT45_12180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LFT45_12195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LFT45_12200	COG0484	heat shock protein binding
LFT45_12205	COG1420	regulation of RNA biosynthetic process
LFT45_12220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LFT45_12225	COG0481	GTPase activity
LFT45_12235	COG0268	Binds directly to 16S ribosomal RNA
LFT45_12270	COG1307	EDD domain protein, DegV family
LFT45_12275	COG0495	leucyl-tRNA aminoacylation
LFT45_12280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LFT45_12285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LFT45_12290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LFT45_12295	COG2390	Transcriptional regulator
LFT45_12305	COG0656	L-ascorbic acid biosynthetic process
LFT45_12315	COG0438	transferase activity, transferring glycosyl groups
LFT45_12325	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LFT45_12335	COG1758	RNA polymerase activity
LFT45_12340	COG0194	GDP metabolic process
LFT45_12345	COG0194	GDP metabolic process
LFT45_12350	COG0284	orotidine-5'-phosphate decarboxylase activity
LFT45_12355	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LFT45_12360	COG0505	Belongs to the CarA family
LFT45_12370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LFT45_12375	COG0540	Belongs to the ATCase OTCase family
LFT45_12380	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LFT45_12390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LFT45_12395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LFT45_12405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LFT45_12410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LFT45_12415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LFT45_12420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LFT45_12430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LFT45_12435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LFT45_12450	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LFT45_12485	COG1053	succinate dehydrogenase
LFT45_12490	COG1414	Transcriptional regulator
LFT45_12500	COG1053	succinate dehydrogenase
LFT45_12510	COG0477	Major facilitator Superfamily
LFT45_12525	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LFT45_12535	COG0124	histidyl-tRNA synthetase
LFT45_12545	COG1196	nuclear chromosome segregation
LFT45_12555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LFT45_12560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LFT45_12565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LFT45_12575	COG2255	four-way junction helicase activity
LFT45_12580	COG0632	four-way junction helicase activity
LFT45_12585	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LFT45_12590	COG0217	transcriptional regulatory protein
LFT45_12595	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LFT45_12600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LFT45_12620	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LFT45_12625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LFT45_12635	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LFT45_12640	COG0587	DNA-directed DNA polymerase activity
LFT45_12655	COG0077	Prephenate dehydratase
LFT45_12655	COG1605	Chorismate mutase
LFT45_12665	COG2135	peptidase activity
LFT45_12790	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LFT45_12805	COG1234	tRNA 3'-trailer cleavage
LFT45_12810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LFT45_12825	COG0412	Dienelactone hydrolase
LFT45_12835	COG0656	L-ascorbic acid biosynthetic process
LFT45_12865	COG0494	nUDIX hydrolase
LFT45_12875	COG3201	nicotinamide mononucleotide transporter
LFT45_12885	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LFT45_12890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LFT45_12895	COG1780	Probably involved in ribonucleotide reductase function
LFT45_12905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LFT45_12915	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
LFT45_12930	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LFT45_12950	COG1846	Transcriptional regulator
LFT45_12950	COG1940	carbohydrate kinase activity
LFT45_12955	COG2813	Specifically methylates the guanine in position
LFT45_12985	COG0799	negative regulation of ribosome biogenesis
LFT45_12995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LFT45_13005	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LFT45_13010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LFT45_13015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LFT45_13020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LFT45_13025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LFT45_13030	COG0352	thiamine-phosphate diphosphorylase activity
LFT45_13030	COG0351	phosphomethylpyrimidine kinase
LFT45_13030	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LFT45_13035	COG1530	ribonuclease E activity
LFT45_13045	COG0105	UTP biosynthetic process
LFT45_13055	COG0285	dihydrofolate synthase activity
LFT45_13060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LFT45_13075	COG3189	MarR family transcriptional regulator
LFT45_13080	COG0525	valine-tRNA ligase activity
LFT45_13085	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LFT45_13090	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LFT45_13095	COG0740	serine-type endopeptidase activity
LFT45_13100	COG0740	serine-type endopeptidase activity
LFT45_13105	COG0544	peptidyl-prolyl cis-trans isomerase activity
LFT45_13145	COG0668	transmembrane transport
LFT45_13160	COG1946	Acyl-CoA thioesterase
LFT45_13175	COG0629	single-stranded DNA binding
LFT45_13200	COG1082	Xylose isomerase domain protein TIM barrel
LFT45_13210	COG0673	inositol 2-dehydrogenase activity
LFT45_13215	COG1609	Transcriptional regulator
LFT45_13245	COG0242	peptide deformylase activity
LFT45_13280	COG3022	response to hydroperoxide
LFT45_13290	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LFT45_13295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LFT45_13305	COG1045	serine acetyltransferase
LFT45_13310	COG0300	oxidoreductase activity
LFT45_13315	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LFT45_13325	COG1063	alcohol dehydrogenase
LFT45_13330	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_13335	COG2084	Dehydrogenase
LFT45_13340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LFT45_13345	COG0477	Major facilitator Superfamily
LFT45_13380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LFT45_13395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LFT45_13400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LFT45_13405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LFT45_13415	COG4974	Belongs to the 'phage' integrase family
LFT45_13430	COG0792	nuclease activity
LFT45_13440	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LFT45_13450	COG0681	Belongs to the peptidase S26 family
LFT45_13455	COG0335	large ribosomal subunit rRNA binding
LFT45_13460	COG0336	Belongs to the RNA methyltransferase TrmD family
LFT45_13465	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LFT45_13470	COG1837	Belongs to the UPF0109 family
LFT45_13475	COG0228	four-way junction DNA binding
LFT45_13485	COG2514	catechol 2,3-dioxygenase activity
LFT45_13510	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LFT45_13535	COG1196	nuclear chromosome segregation
LFT45_13540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LFT45_13545	COG0571	ribonuclease III activity
LFT45_13550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LFT45_13560	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LFT45_13575	COG0742	ribosomal rna small subunit methyltransferase
LFT45_13600	COG1181	Belongs to the D-alanine--D-alanine ligase family
LFT45_13605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LFT45_13615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LFT45_13620	COG0066	3-isopropylmalate dehydratase activity
LFT45_13625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LFT45_13630	COG1414	Transcriptional regulator
LFT45_13650	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LFT45_13675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LFT45_13680	COG0179	Fumarylacetoacetate (FAA) hydrolase
LFT45_13690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LFT45_13695	COG0473	3-isopropylmalate dehydrogenase activity
LFT45_13715	COG0577	efflux transmembrane transporter activity
LFT45_13715	COG1136	(ABC) transporter
LFT45_13730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LFT45_13735	COG0440	acetolactate synthase activity
LFT45_13745	COG0129	dihydroxy-acid dehydratase activity
LFT45_13750	COG0228	four-way junction DNA binding
LFT45_13770	COG1609	Transcriptional regulator
LFT45_13775	COG0673	inositol 2-dehydrogenase activity
LFT45_13780	COG0673	inositol 2-dehydrogenase activity
LFT45_13785	COG0673	inositol 2-dehydrogenase activity
LFT45_13795	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT45_13810	COG0673	inositol 2-dehydrogenase activity
LFT45_13815	COG1609	Transcriptional regulator
LFT45_13840	COG0747	negative chemotaxis
LFT45_13845	COG0579	oxidoreductase
LFT45_13850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LFT45_13860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_13870	COG1305	Transglutaminase-like
LFT45_13885	COG0179	Fumarylacetoacetate (FAA) hydrolase
LFT45_13890	COG1104	cysteine desulfurase activity
LFT45_13900	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LFT45_13905	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LFT45_13915	COG1113	amino acid transport
LFT45_13930	COG0477	Major facilitator Superfamily
LFT45_13935	COG1414	Transcriptional regulator
LFT45_13945	COG0419	ATPase involved in DNA repair
LFT45_13950	COG0420	3'-5' exonuclease activity
LFT45_13975	COG0586	Pfam SNARE associated Golgi protein
LFT45_13980	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LFT45_13985	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LFT45_13990	COG1234	tRNA 3'-trailer cleavage
LFT45_13995	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LFT45_14005	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LFT45_14015	COG1335	isochorismatase
LFT45_14030	COG0363	glucosamine-6-phosphate deaminase activity
LFT45_14045	COG1902	pentaerythritol trinitrate reductase activity
LFT45_14060	COG0628	permease
LFT45_14075	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LFT45_14090	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LFT45_14095	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LFT45_14100	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LFT45_14105	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LFT45_14110	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LFT45_14115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LFT45_14120	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LFT45_14125	COG0356	it plays a direct role in the translocation of protons across the membrane
LFT45_14140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LFT45_14160	COG2890	protein-(glutamine-N5) methyltransferase activity
LFT45_14165	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LFT45_14175	COG0083	homoserine kinase activity
LFT45_14180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LFT45_14185	COG0460	homoserine dehydrogenase
LFT45_14190	COG0019	diaminopimelate decarboxylase activity
LFT45_14195	COG0018	arginyl-trna synthetase
LFT45_14240	COG1643	Atp-dependent helicase
LFT45_14250	COG0537	adenosine 5'-monophosphoramidase activity
LFT45_14255	COG1064	alcohol dehydrogenase
LFT45_14265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LFT45_14285	COG1121	(ABC) transporter
LFT45_14305	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT45_14305	COG0567	Dehydrogenase, E1 component
LFT45_14330	COG1595	DNA-templated transcription, initiation
LFT45_14340	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LFT45_14350	COG0483	inositol monophosphate 1-phosphatase activity
LFT45_14355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LFT45_14370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LFT45_14375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LFT45_14400	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LFT45_14415	COG2884	Cell division ATP-binding protein ftsE
LFT45_14420	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LFT45_14475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LFT45_14480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LFT45_14490	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LFT45_14495	COG2089	acid synthase
LFT45_14505	COG1083	cytidylyl-transferase
LFT45_14525	COG1216	Glycosyl transferase, family 2
LFT45_14550	COG1216	Glycosyl transferase, family 2
LFT45_14580	COG2902	Dehydrogenase
LFT45_14615	COG0653	protein targeting
LFT45_14620	COG3214	Protein conserved in bacteria
LFT45_14625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LFT45_14635	COG5401	PFAM Sporulation and spore germination
LFT45_14640	COG5002	protein histidine kinase activity
LFT45_14640	COG5000	phosphorelay sensor kinase activity
LFT45_14665	COG0714	Associated with various cellular activities
LFT45_14705	COG0601	transmembrane transport
LFT45_14715	COG0482	sulfurtransferase activity
LFT45_14745	COG0484	heat shock protein binding
LFT45_14750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LFT45_14755	COG1595	DNA-templated transcription, initiation
LFT45_14775	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LFT45_14785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LFT45_14795	COG1842	Phage shock protein A
LFT45_14800	COG0415	Belongs to the DNA photolyase family
LFT45_14820	COG1615	UPF0182 protein
LFT45_14845	COG2816	NAD+ diphosphatase activity
LFT45_14875	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LFT45_14880	COG2011	ABC-type metal ion transport system permease component
LFT45_14885	COG1464	Belongs to the NlpA lipoprotein family
LFT45_14890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LFT45_14895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_14900	COG0113	porphobilinogen synthase activity
LFT45_14910	COG0181	hydroxymethylbilane synthase activity
LFT45_14915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LFT45_14920	COG3253	May function as heme-dependent peroxidase
LFT45_14935	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LFT45_14940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LFT45_14985	COG2154	pterin-4-alpha-carbinolamine dehydratase
LFT45_14990	COG2022	thiamine diphosphate biosynthetic process
LFT45_15000	COG2022	thiamine diphosphate biosynthetic process
LFT45_15000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LFT45_15005	COG0352	thiamine-phosphate diphosphorylase activity
LFT45_15015	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LFT45_15020	COG0513	Belongs to the DEAD box helicase family
LFT45_15025	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LFT45_15035	COG0006	proline dipeptidase activity
LFT45_15045	COG2239	Acts as a magnesium transporter
LFT45_15060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LFT45_15070	COG1595	DNA-templated transcription, initiation
LFT45_15095	COG1611	Belongs to the LOG family
LFT45_15100	COG1126	abc transporter atp-binding protein
LFT45_15105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LFT45_15110	COG0765	amino acid transport
LFT45_15115	COG0765	amino acid transport
LFT45_15120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LFT45_15125	COG2171	N-acyltransferase activity
LFT45_15140	COG3226	Transcriptional regulator
LFT45_15145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LFT45_15180	COG1217	gtp-binding protein TYPA
LFT45_15190	COG4172	Belongs to the ABC transporter superfamily
LFT45_15200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LFT45_15210	COG4166	transmembrane transport
LFT45_15215	COG0012	GTP binding
LFT45_15220	COG1322	Protein conserved in bacteria
LFT45_15225	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LFT45_15235	COG1570	exodeoxyribonuclease VII activity
LFT45_15240	COG1722	exodeoxyribonuclease VII activity
LFT45_15245	COG2326	polyphosphate kinase activity
LFT45_15265	COG1174	glycine betaine transport
LFT45_15275	COG1162	GTPase activity
LFT45_15290	COG2971	BadF BadG BcrA BcrD
LFT45_15300	COG0583	DNA-binding transcription factor activity
LFT45_15305	COG2814	Major facilitator Superfamily
LFT45_15340	COG0598	Magnesium transport protein CorA
LFT45_15360	COG3415	Transposase
LFT45_15360	COG2801	Transposase and inactivated derivatives
LFT45_15385	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LFT45_15390	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LFT45_15415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LFT45_15415	COG0519	Catalyzes the synthesis of GMP from XMP
LFT45_15435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LFT45_15440	COG0516	GMP reductase activity
LFT45_15450	COG1132	(ABC) transporter
LFT45_15465	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LFT45_15465	COG2755	lipolytic protein G-D-S-L family
LFT45_15470	COG0459	protein refolding
LFT45_15475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LFT45_15490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LFT45_15495	COG1472	Belongs to the glycosyl hydrolase 3 family
LFT45_15500	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LFT45_15505	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LFT45_15520	COG0802	atpase or kinase
LFT45_15525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LFT45_15535	COG1486	melibiose metabolic process
LFT45_15540	COG0438	transferase activity, transferring glycosyl groups
LFT45_15545	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LFT45_15570	COG0667	Aldo Keto reductase
LFT45_15590	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LFT45_15590	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LFT45_15595	COG0736	holo-[acyl-carrier-protein] synthase activity
LFT45_15605	COG1072	(Pantothenic acid kinase))
LFT45_15615	COG1970	mechanosensitive ion channel activity
LFT45_15620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LFT45_15625	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LFT45_15630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LFT45_15660	COG0455	bacterial-type flagellum organization
LFT45_15705	COG0489	protein tyrosine kinase activity
LFT45_15740	COG5002	protein histidine kinase activity
LFT45_15755	COG0745	RESPONSE REGULATOR receiver
LFT45_15760	COG0101	tRNA pseudouridine synthase activity
LFT45_15765	COG0203	ribosomal protein L17
LFT45_15770	COG0202	RNA polymerase activity
LFT45_15775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LFT45_15780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LFT45_15785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LFT45_15790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LFT45_15795	COG3191	aminopeptidase activity
LFT45_15805	COG0563	adenylate kinase activity
LFT45_15815	COG0200	Binds to the 23S rRNA
LFT45_15820	COG1841	ribosomal large subunit assembly
LFT45_15825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LFT45_15835	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LFT45_15840	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LFT45_15845	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LFT45_15850	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LFT45_15855	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LFT45_15860	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LFT45_15870	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LFT45_15875	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LFT45_15880	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LFT45_15885	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LFT45_15890	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LFT45_15895	COG0089	rRNA binding
LFT45_15900	COG0088	Forms part of the polypeptide exit tunnel
LFT45_15905	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LFT45_15910	COG0051	transcription antitermination factor activity, RNA binding
LFT45_15920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LFT45_15925	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LFT45_15930	COG0049	tRNA binding
LFT45_15935	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LFT45_15940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LFT45_15945	COG0085	RNA polymerase activity
LFT45_15950	COG0183	Belongs to the thiolase family
LFT45_15955	COG0442	prolyl-tRNA aminoacylation
LFT45_15960	COG0222	ribosome binding
LFT45_15965	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LFT45_15980	COG0081	regulation of translation
LFT45_15985	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LFT45_15995	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LFT45_16005	COG0436	Aminotransferase
LFT45_16015	COG2801	Transposase and inactivated derivatives
LFT45_16020	COG2197	response regulator
LFT45_16065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LFT45_16075	COG3485	protocatechuate 3,4-dioxygenase
LFT45_16085	COG0745	RESPONSE REGULATOR receiver
LFT45_16090	COG0456	acetyltransferase
LFT45_16095	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LFT45_16115	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LFT45_16120	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LFT45_16145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LFT45_16155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LFT45_16165	COG2030	dehydratase
LFT45_16195	COG4989	oxidoreductase activity
LFT45_16200	COG0366	Alpha amylase catalytic
LFT45_16205	COG0395	ABC-type sugar transport system, permease component
LFT45_16210	COG1175	transmembrane transport
LFT45_16220	COG1940	carbohydrate kinase activity
LFT45_16230	COG0702	epimerase
LFT45_16270	COG0754	glutathionylspermidine amidase activity
LFT45_16330	COG5650	phosphatidylinositol metabolic process
LFT45_16345	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LFT45_16350	COG0346	lactoylglutathione lyase activity
LFT45_16370	COG2826	transposase and inactivated derivatives, IS30 family
LFT45_16375	COG0318	PFAM AMP-dependent synthetase and ligase
LFT45_16385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LFT45_16390	COG3942	CHAP domain
LFT45_16390	COG1388	LysM domain
LFT45_16395	COG2801	Transposase and inactivated derivatives
LFT45_16395	COG3415	Transposase
LFT45_16410	COG1666	GTP binding
LFT45_16420	COG0501	Belongs to the peptidase M48B family
LFT45_16445	COG0531	amino acid
LFT45_16495	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_16515	COG3848	Pyruvate phosphate dikinase
LFT45_16515	COG0574	Belongs to the PEP-utilizing enzyme family
LFT45_16530	COG2186	Transcriptional regulator
LFT45_16565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LFT45_16565	COG1648	precorrin-2 dehydrogenase activity
LFT45_16580	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LFT45_16590	COG1690	Belongs to the RtcB family
LFT45_16610	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LFT45_16620	COG2860	membrane
LFT45_16635	COG0142	geranyltranstransferase activity
LFT45_16645	COG2226	methyltransferase
LFT45_16650	COG1169	isochorismate synthase
LFT45_16655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LFT45_16660	COG0765	amino acid transport
LFT45_16675	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LFT45_16680	COG2801	Transposase and inactivated derivatives
LFT45_16695	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_16700	COG4585	Histidine kinase
LFT45_16710	COG5002	protein histidine kinase activity
LFT45_16750	COG0436	Aminotransferase
LFT45_16780	COG4172	Belongs to the ABC transporter superfamily
LFT45_16785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LFT45_16790	COG0601	transmembrane transport
LFT45_16795	COG4166	transmembrane transport
LFT45_16840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LFT45_16845	COG0569	domain protein
LFT45_16880	COG1472	Belongs to the glycosyl hydrolase 3 family
LFT45_16955	COG0531	amino acid
LFT45_16960	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_16970	COG0765	amino acid transport
LFT45_16975	COG0765	amino acid transport
LFT45_17025	COG2826	transposase and inactivated derivatives, IS30 family
LFT45_17030	COG0477	Major facilitator Superfamily
LFT45_17060	COG0741	lytic transglycosylase activity
LFT45_17060	COG0739	heme binding
LFT45_17060	COG1196	nuclear chromosome segregation
LFT45_17065	COG2124	cytochrome p450
LFT45_17065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LFT45_17100	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LFT45_17110	COG0443	Heat shock 70 kDa protein
LFT45_17170	COG4152	abc transporter atp-binding protein
LFT45_17180	COG3655	Transcriptional regulator
LFT45_17190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LFT45_17200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LFT45_17205	COG1404	Belongs to the peptidase S8 family
LFT45_17245	COG2755	lipolytic protein G-D-S-L family
LFT45_17245	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LFT45_17290	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT45_17315	COG0489	protein tyrosine kinase activity
LFT45_17330	COG0297	glycogen (starch) synthase activity
LFT45_17335	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LFT45_17340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LFT45_17350	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LFT45_17365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LFT45_17375	COG1024	Enoyl-CoA hydratase
LFT45_17380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LFT45_17385	COG2151	metal-sulfur cluster biosynthetic enzyme
LFT45_17390	COG3396	Phenylacetate-CoA oxygenase
LFT45_17395	COG3460	Phenylacetate-CoA oxygenase
LFT45_17400	COG3396	Phenylacetate-CoA oxygenase
LFT45_17430	COG3979	chitinase
LFT45_17495	COG0277	FAD linked oxidase domain protein
LFT45_17505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LFT45_17520	COG2217	Heavy metal translocating P-type atpase
LFT45_17535	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_17560	COG2755	lipolytic protein G-D-S-L family
LFT45_17590	COG1011	Hydrolase
LFT45_17620	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LFT45_17630	COG1064	alcohol dehydrogenase
LFT45_17655	COG0492	ferredoxin-NADP+ reductase activity
LFT45_17660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LFT45_17665	COG0492	ferredoxin-NADP+ reductase activity
LFT45_17675	COG0640	Transcriptional regulator
LFT45_17695	COG0601	transmembrane transport
LFT45_17700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LFT45_17705	COG0444	Belongs to the ABC transporter superfamily
LFT45_17710	COG4608	Belongs to the ABC transporter superfamily
LFT45_17720	COG1621	beta-fructofuranosidase activity
LFT45_17765	COG2826	transposase and inactivated derivatives, IS30 family
LFT45_17790	COG1609	Transcriptional regulator
LFT45_17795	COG2814	Major facilitator Superfamily
LFT45_17855	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LFT45_17915	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LFT45_17925	COG1063	alcohol dehydrogenase
LFT45_17965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LFT45_17970	COG1316	TRANSCRIPTIONal
LFT45_17985	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LFT45_18020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LFT45_18055	COG5002	protein histidine kinase activity
LFT45_18080	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LFT45_18085	COG0280	phosphate acetyltransferase
LFT45_18085	COG0857	belongs to the CobB CobQ family
LFT45_18100	COG2050	protein possibly involved in aromatic compounds catabolism
LFT45_18110	COG2132	Multicopper oxidase
LFT45_18130	COG2801	Transposase and inactivated derivatives
LFT45_18140	COG2030	dehydratase
LFT45_18140	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_18145	COG2050	protein possibly involved in aromatic compounds catabolism
LFT45_18150	COG0390	transport system, permease component
LFT45_18185	COG1250	3-hydroxyacyl-CoA dehydrogenase
LFT45_18190	COG1024	Enoyl-CoA hydratase
LFT45_18195	COG0183	Belongs to the thiolase family
LFT45_18240	COG0488	(ABC) transporter
LFT45_18245	COG1266	CAAX protease self-immunity
LFT45_18255	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LFT45_18285	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LFT45_18295	COG0785	Cytochrome C biogenesis protein
LFT45_18300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LFT45_18305	COG0406	alpha-ribazole phosphatase activity
LFT45_18310	COG2353	YceI-like domain
LFT45_18320	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LFT45_18345	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LFT45_18350	COG2814	Major facilitator Superfamily
LFT45_18355	COG1070	Carbohydrate kinase
LFT45_18360	COG3347	Dehydrogenase
LFT45_18360	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_18365	COG4952	isomerase
LFT45_18370	COG3254	rhamnose metabolic process
LFT45_18395	COG0395	ABC-type sugar transport system, permease component
LFT45_18400	COG1175	transmembrane transport
LFT45_18415	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_18420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LFT45_18430	COG0673	inositol 2-dehydrogenase activity
LFT45_18435	COG1609	Transcriptional regulator
LFT45_18445	COG2814	Major facilitator Superfamily
LFT45_18455	COG2186	Transcriptional regulator
LFT45_18465	COG0640	Transcriptional regulator
LFT45_18470	COG0123	including yeast histone deacetylase and acetoin utilization protein
LFT45_18475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LFT45_18480	COG0569	domain protein
LFT45_18485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LFT45_18490	COG0248	Ppx GppA phosphatase
LFT45_18500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LFT45_18500	COG1754	DNA topoisomerase type I activity
LFT45_18515	COG2890	protein-(glutamine-N5) methyltransferase activity
LFT45_18535	COG1054	Belongs to the UPF0176 family
LFT45_18545	COG1111	helicase
LFT45_18545	COG1205	dead DEAH box helicase
LFT45_18595	COG1051	belongs to the nudix hydrolase family
LFT45_18610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LFT45_18625	COG0395	ABC-type sugar transport system, permease component
LFT45_18630	COG1349	DNA-binding transcription factor activity
LFT45_18645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LFT45_18670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LFT45_18675	COG1408	metallophosphoesterase
LFT45_18680	COG1132	(ABC) transporter
LFT45_18685	COG1132	(ABC) transporter
LFT45_18710	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LFT45_18715	COG0151	Belongs to the GarS family
LFT45_18735	COG1301	dicarboxylic acid transport
LFT45_18750	COG4221	oxidoreductase activity
LFT45_18760	COG1953	Uracil, thiamine, allantoin
LFT45_18765	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LFT45_18785	COG0667	Aldo Keto reductase
LFT45_18790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LFT45_18800	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LFT45_18800	COG3608	succinylglutamate desuccinylase aspartoacylase
LFT45_18805	COG2252	PERMEase
LFT45_18810	COG0590	tRNA wobble adenosine to inosine editing
LFT45_18835	COG2233	PERMEase
LFT45_18840	COG3415	Transposase
LFT45_18840	COG2801	Transposase and inactivated derivatives
LFT45_18845	COG1414	Transcriptional regulator
LFT45_18855	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LFT45_18865	COG3257	ureidoglycine aminohydrolase activity
LFT45_18875	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_18890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LFT45_18900	COG3387	PFAM Glycoside hydrolase 15-related
LFT45_18930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LFT45_18940	COG0484	heat shock protein binding
LFT45_18975	COG3540	Alkaline phosphatase
LFT45_18980	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_18985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LFT45_18990	COG0800	Aldolase
LFT45_18995	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_19000	COG0395	ABC-type sugar transport system, permease component
LFT45_19005	COG1175	transmembrane transport
LFT45_19020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LFT45_19060	COG1072	(Pantothenic acid kinase))
LFT45_19075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_19080	COG2267	carboxylic ester hydrolase activity
LFT45_19095	COG0598	Magnesium transport protein CorA
LFT45_19120	COG2186	Transcriptional regulator
LFT45_19130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LFT45_19165	COG1132	(ABC) transporter
LFT45_19220	COG0671	phosphoesterase, PA-phosphatase related
LFT45_19245	COG4336	lyase activity
LFT45_19260	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LFT45_19265	COG1984	allophanate hydrolase subunit 2
LFT45_19270	COG4770	biotin carboxylase activity
LFT45_19280	COG0473	3-isopropylmalate dehydrogenase activity
LFT45_19290	COG3842	ATPase activity
LFT45_19295	COG4149	molybdate abc transporter
LFT45_19305	COG1802	Transcriptional regulator
LFT45_19325	COG1053	succinate dehydrogenase
LFT45_19350	COG0477	Major facilitator Superfamily
LFT45_19360	COG1414	Transcriptional regulator
LFT45_19365	COG0477	Major facilitator Superfamily
LFT45_19370	COG0583	DNA-binding transcription factor activity
LFT45_19380	COG1063	alcohol dehydrogenase
LFT45_19385	COG1053	succinate dehydrogenase
LFT45_19390	COG1609	Transcriptional regulator
LFT45_19395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LFT45_19400	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_19405	COG0246	Mannitol dehydrogenase
LFT45_19410	COG1063	alcohol dehydrogenase
LFT45_19415	COG0477	Major facilitator Superfamily
LFT45_19435	COG5001	Diguanylate cyclase
LFT45_19445	COG1737	Transcriptional regulator
LFT45_19455	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_19475	COG3265	gluconokinase activity
LFT45_19480	COG1063	alcohol dehydrogenase
LFT45_19485	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_19495	COG4221	oxidoreductase activity
LFT45_19500	COG0477	Major facilitator Superfamily
LFT45_19510	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LFT45_19515	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LFT45_19520	COG0583	DNA-binding transcription factor activity
LFT45_19535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LFT45_19540	COG0436	Aminotransferase
LFT45_19555	COG0747	negative chemotaxis
LFT45_19560	COG0601	transmembrane transport
LFT45_19565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LFT45_19575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_19600	COG3585	molybdate ion transport
LFT45_19645	COG0395	ABC-type sugar transport system, permease component
LFT45_19650	COG1175	transmembrane transport
LFT45_19660	COG1609	Transcriptional regulator
LFT45_19670	COG2154	pterin-4-alpha-carbinolamine dehydratase
LFT45_19675	COG0702	epimerase
LFT45_19680	COG2267	carboxylic ester hydrolase activity
LFT45_19730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LFT45_19755	COG0667	Aldo Keto reductase
LFT45_19780	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LFT45_19820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LFT45_19825	COG0318	PFAM AMP-dependent synthetase and ligase
LFT45_19830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LFT45_19850	COG0583	DNA-binding transcription factor activity
LFT45_19860	COG0833	amino acid
LFT45_19935	COG1388	LysM domain
LFT45_19935	COG3942	CHAP domain
LFT45_19955	COG1609	Transcriptional regulator
LFT45_19965	COG4209	transmembrane transport
LFT45_19970	COG0395	ABC-type sugar transport system, permease component
LFT45_19975	COG2182	Extracellular solute-binding protein
LFT45_19985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LFT45_19990	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LFT45_19995	COG1846	Transcriptional regulator
LFT45_19995	COG1940	carbohydrate kinase activity
LFT45_20005	COG1653	transport
LFT45_20010	COG1175	transmembrane transport
LFT45_20015	COG0395	ABC-type sugar transport system, permease component
LFT45_20045	COG0384	phenazine biosynthesis protein PhzF
LFT45_20075	COG1132	(ABC) transporter
LFT45_20090	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LFT45_20100	COG0640	Transcriptional regulator
LFT45_20110	COG3622	Belongs to the hyi family
LFT45_20115	COG2084	Dehydrogenase
LFT45_20120	COG3960	tartronate-semialdehyde synthase activity
LFT45_20125	COG1929	Belongs to the glycerate kinase type-1 family
LFT45_20130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LFT45_20150	COG1760	l-serine dehydratase
LFT45_20175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LFT45_20180	COG1802	Transcriptional regulator
LFT45_20205	COG0179	Fumarylacetoacetate (FAA) hydrolase
LFT45_20220	COG3250	beta-galactosidase activity
LFT45_20225	COG0657	acetylesterase activity
LFT45_20260	COG1309	transcriptional regulator
LFT45_20270	COG2200	EAL domain
LFT45_20270	COG2199	diguanylate cyclase activity
LFT45_20275	COG3250	beta-galactosidase activity
LFT45_20305	COG1819	glycosyl
LFT45_20310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LFT45_20325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LFT45_20330	COG0438	transferase activity, transferring glycosyl groups
LFT45_20340	COG0477	Major facilitator Superfamily
LFT45_20370	COG3404	Formiminotransferase-cyclodeaminase
LFT45_20395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LFT45_20435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LFT45_20450	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_20455	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LFT45_20465	COG5002	protein histidine kinase activity
LFT45_20475	COG0745	RESPONSE REGULATOR receiver
LFT45_20480	COG1215	transferase activity, transferring glycosyl groups
LFT45_20485	COG1366	Belongs to the anti-sigma-factor antagonist family
LFT45_20500	COG2205	protein histidine kinase activity
LFT45_20510	COG2351	hydroxyisourate hydrolase activity
LFT45_20530	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LFT45_20550	COG0542	response to heat
LFT45_20575	COG3304	Inner membrane component domain
LFT45_20585	COG0135	phosphoribosylanthranilate isomerase activity
LFT45_20595	COG1528	Iron-storage protein
LFT45_20620	COG1113	amino acid transport
LFT45_20630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LFT45_20635	COG2146	nitrite reductase [NAD(P)H] activity
LFT45_20655	COG1473	amidohydrolase
LFT45_20660	COG0477	Major facilitator Superfamily
LFT45_20665	COG2807	transmembrane transport
LFT45_20675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LFT45_20680	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LFT45_20695	COG1595	DNA-templated transcription, initiation
LFT45_20710	COG1621	beta-fructofuranosidase activity
LFT45_20715	COG0395	ABC-type sugar transport system, permease component
LFT45_20720	COG1175	transmembrane transport
LFT45_20730	COG1609	Transcriptional regulator
LFT45_20740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LFT45_20755	COG2186	Transcriptional regulator
LFT45_20760	COG0477	Major facilitator Superfamily
LFT45_20790	COG0659	secondary active sulfate transmembrane transporter activity
LFT45_20795	COG2084	Dehydrogenase
LFT45_20800	COG1082	Xylose isomerase domain protein TIM barrel
LFT45_20805	COG0149	triose-phosphate isomerase activity
LFT45_20810	COG0698	ribose 5-phosphate isomerase
LFT45_20815	COG2376	Dihydroxyacetone kinase
LFT45_20825	COG2186	Transcriptional regulator
LFT45_20850	COG3135	benzoate transporter
LFT45_20870	COG4941	Belongs to the sigma-70 factor family
LFT45_20880	COG0563	adenylate kinase activity
LFT45_20890	COG3290	protein histidine kinase activity
LFT45_20910	COG0589	response to stress
LFT45_20915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LFT45_20920	COG3848	Pyruvate phosphate dikinase
LFT45_20920	COG0574	Belongs to the PEP-utilizing enzyme family
LFT45_20925	COG0789	Transcriptional regulator
LFT45_20930	COG0484	heat shock protein binding
LFT45_20935	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LFT45_20940	COG0443	Heat shock 70 kDa protein
LFT45_20960	COG2409	Drug exporters of the RND superfamily
LFT45_20975	COG1280	lysine exporter protein (LysE YggA)
LFT45_20990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LFT45_21000	COG2200	EAL domain
LFT45_21000	COG3287	FIST C domain
LFT45_21000	COG2199	diguanylate cyclase activity
LFT45_21010	COG2986	histidine ammonia-lyase
LFT45_21040	COG0318	PFAM AMP-dependent synthetase and ligase
LFT45_21045	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LFT45_21050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LFT45_21070	COG1122	ATPase activity
LFT45_21075	COG4721	ABC-type cobalt transport system, permease component
LFT45_21080	COG4702	Belongs to the UPF0303 family
LFT45_21095	COG1320	monovalent cation:proton antiporter activity
LFT45_21100	COG2212	antiporter activity
LFT45_21110	COG0651	ATP synthesis coupled electron transport
LFT45_21115	COG1006	Multisubunit Na H antiporter MnhC subunit
LFT45_21120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LFT45_21120	COG2111	Na H antiporter
LFT45_21135	COG0475	glutathione-regulated potassium exporter activity
LFT45_21145	COG0717	Belongs to the dCTP deaminase family
LFT45_21165	COG0583	DNA-binding transcription factor activity
LFT45_21175	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_21180	COG0531	amino acid
LFT45_21190	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LFT45_21205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_21210	COG0433	COG0433 Predicted ATPase
LFT45_21230	COG3336	cytochrome c oxidase
LFT45_21235	COG0776	regulation of translation
LFT45_21285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LFT45_21290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LFT45_21295	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LFT45_21300	COG1017	nitric oxide dioxygenase activity
LFT45_21300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LFT45_21340	COG1120	ATPase activity
LFT45_21345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LFT45_21350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LFT45_21405	COG3012	SEC-C Motif Domain Protein
LFT45_21415	COG0667	Aldo Keto reductase
LFT45_21430	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_21445	COG3959	Transketolase, thiamine diphosphate binding domain
LFT45_21450	COG3958	Transketolase
LFT45_21470	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LFT45_21475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LFT45_21515	COG2186	Transcriptional regulator
LFT45_21540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LFT45_21540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LFT45_21550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LFT45_21565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LFT45_21580	COG1522	sequence-specific DNA binding
LFT45_21585	COG1280	lysine exporter protein (LysE YggA)
LFT45_21605	COG0281	malic enzyme
LFT45_21620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LFT45_21625	COG0477	Major facilitator Superfamily
LFT45_21630	COG0477	Major facilitator Superfamily
LFT45_21635	COG2814	Major facilitator Superfamily
LFT45_21645	COG1609	Transcriptional regulator
LFT45_21655	COG1175	transmembrane transport
LFT45_21660	COG0395	ABC-type sugar transport system, permease component
LFT45_21665	COG3250	beta-galactosidase activity
LFT45_21670	COG1733	regulation of RNA biosynthetic process
LFT45_21675	COG0702	epimerase
LFT45_21680	COG0246	Mannitol dehydrogenase
LFT45_21685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LFT45_21685	COG2213	PTS system mannitol-specific
LFT45_21695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LFT45_21730	COG0686	Belongs to the AlaDH PNT family
LFT45_21735	COG0673	inositol 2-dehydrogenase activity
LFT45_21745	COG0431	NADPH-dependent FMN reductase
LFT45_21760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LFT45_21780	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT45_21785	COG0022	dehydrogenase e1 component
LFT45_21795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LFT45_21800	COG1950	PFAM Membrane protein of
LFT45_21815	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LFT45_21820	COG0406	alpha-ribazole phosphatase activity
LFT45_21830	COG1607	acyl-coa hydrolase
LFT45_21855	COG0243	molybdopterin cofactor binding
LFT45_21880	COG0667	Aldo Keto reductase
LFT45_21900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LFT45_21910	COG0583	DNA-binding transcription factor activity
LFT45_21945	COG1414	Transcriptional regulator
LFT45_21950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LFT45_21960	COG0183	Belongs to the thiolase family
LFT45_21965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LFT45_21975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LFT45_21980	COG3485	protocatechuate 3,4-dioxygenase
LFT45_21985	COG3485	protocatechuate 3,4-dioxygenase
LFT45_21990	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LFT45_21990	COG1082	Xylose isomerase domain protein TIM barrel
LFT45_21995	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LFT45_22000	COG1414	Transcriptional regulator
LFT45_22010	COG1793	dna ligase
LFT45_22025	COG0366	Alpha amylase catalytic
LFT45_22035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LFT45_22055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LFT45_22070	COG1937	Protein conserved in bacteria
LFT45_22095	COG0697	spore germination
LFT45_22115	COG0534	Mate efflux family protein
LFT45_22120	COG2259	Doxx family
LFT45_22135	COG0305	Participates in initiation and elongation during chromosome replication
LFT45_22165	COG0359	binds to the 23S rRNA
LFT45_22170	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LFT45_22180	COG0360	Binds together with S18 to 16S ribosomal RNA
LFT45_22185	COG1742	UPF0060 membrane protein
LFT45_22190	COG1113	amino acid transport
LFT45_22195	COG1362	aminopeptidase activity
LFT45_22205	COG2197	response regulator
LFT45_22210	COG4585	Histidine kinase
LFT45_22220	COG1131	(ABC) transporter
LFT45_22230	COG0738	Major facilitator superfamily
LFT45_22260	COG0406	alpha-ribazole phosphatase activity
LFT45_22265	COG0617	tRNA 3'-terminal CCA addition
LFT45_22285	COG0492	ferredoxin-NADP+ reductase activity
LFT45_22290	COG3118	belongs to the thioredoxin family
LFT45_22300	COG1192	Involved in chromosome partitioning
LFT45_22305	COG0357	Ribosomal RNA small subunit methyltransferase G
LFT45_22315	COG0706	membrane insertase activity
LFT45_22320	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LFT45_22325	COG0594	ribonuclease P activity
LFT45_22330	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LFT45_22365	COG2354	Protein conserved in bacteria
LFT45_22385	COG0785	Cytochrome C biogenesis protein
LFT45_22390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LFT45_22400	COG2124	cytochrome p450
LFT45_22410	COG2132	Multicopper oxidase
LFT45_22435	COG1321	iron dependent repressor
LFT45_22475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LFT45_22480	COG0492	ferredoxin-NADP+ reductase activity
LFT45_22490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LFT45_22495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LFT45_22605	COG1475	DNA binding
LFT45_22645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LFT45_22675	COG1793	dna ligase
LFT45_22680	COG2135	peptidase activity
LFT45_22725	COG1192	Involved in chromosome partitioning
LFT45_22805	COG0741	lytic transglycosylase activity
LFT45_22870	COG0659	secondary active sulfate transmembrane transporter activity
LFT45_22910	COG3336	cytochrome c oxidase
LFT45_22915	COG0640	Transcriptional regulator
LFT45_22955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LFT45_22960	COG2017	converts alpha-aldose to the beta-anomer
LFT45_22970	COG0395	ABC-type sugar transport system, permease component
LFT45_22975	COG1175	transmembrane transport
LFT45_22990	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LFT45_23000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LFT45_23070	COG1475	DNA binding
LFT45_23130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LFT45_23170	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LFT45_23180	COG1192	Involved in chromosome partitioning