locus-tag	class	description
LFT46_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LFT46_00010	COG0592	DNA-directed DNA polymerase activity
LFT46_00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LFT46_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LFT46_00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
LFT46_00030	COG0187	DNA topoisomerase II activity
LFT46_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LFT46_00040	COG3266	domain, Protein
LFT46_00065	COG0463	Glycosyl transferase, family 2
LFT46_00085	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LFT46_00090	COG2818	Glycosylase
LFT46_00100	COG3764	Sortase (surface protein transpeptidase)
LFT46_00115	COG2815	serine threonine protein kinase
LFT46_00115	COG0515	serine threonine protein kinase
LFT46_00120	COG0515	serine threonine protein kinase
LFT46_00140	COG1716	ATPase activity
LFT46_00145	COG1716	ATPase activity
LFT46_00165	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LFT46_00195	COG0346	lactoylglutathione lyase activity
LFT46_00225	COG1846	Transcriptional regulator
LFT46_00250	COG0277	FAD linked oxidase domain protein
LFT46_00260	COG0154	amidase activity
LFT46_00265	COG2957	Belongs to the agmatine deiminase family
LFT46_00275	COG1162	GTPase activity
LFT46_00285	COG1253	flavin adenine dinucleotide binding
LFT46_00295	COG3706	GGDEF domain
LFT46_00315	COG0673	inositol 2-dehydrogenase activity
LFT46_00325	COG1175	transmembrane transport
LFT46_00330	COG1653	transport
LFT46_00340	COG4948	Mandelate Racemase Muconate Lactonizing
LFT46_00345	COG2382	esterase
LFT46_00345	COG3507	Belongs to the glycosyl hydrolase 43 family
LFT46_00345	COG3693	PFAM glycoside hydrolase, family 10
LFT46_00350	COG1609	Transcriptional regulator
LFT46_00360	COG1609	Transcriptional regulator
LFT46_00365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LFT46_00370	COG0765	amino acid transport
LFT46_00375	COG1126	abc transporter atp-binding protein
LFT46_00380	COG0673	inositol 2-dehydrogenase activity
LFT46_00390	COG0659	secondary active sulfate transmembrane transporter activity
LFT46_00420	COG2084	Dehydrogenase
LFT46_00425	COG0477	Major facilitator Superfamily
LFT46_00450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LFT46_00490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LFT46_00510	COG0457	Tetratricopeptide repeat
LFT46_00540	COG1063	alcohol dehydrogenase
LFT46_00545	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_00550	COG2084	Dehydrogenase
LFT46_00565	COG0179	Fumarylacetoacetate (FAA) hydrolase
LFT46_00570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LFT46_00580	COG0460	homoserine dehydrogenase
LFT46_00590	COG1609	Transcriptional regulator
LFT46_00595	COG1957	nucleoside hydrolase
LFT46_00600	COG0477	Major facilitator Superfamily
LFT46_00605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LFT46_00610	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_00655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LFT46_00670	COG0561	phosphatase activity
LFT46_00680	COG0584	glycerophosphoryl diester phosphodiesterase
LFT46_00695	COG2199	diguanylate cyclase activity
LFT46_00695	COG2200	EAL domain
LFT46_00695	COG2203	Gaf domain
LFT46_00705	COG5002	protein histidine kinase activity
LFT46_00725	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_00730	COG1929	Belongs to the glycerate kinase type-1 family
LFT46_00750	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_00770	COG0673	inositol 2-dehydrogenase activity
LFT46_00775	COG0673	inositol 2-dehydrogenase activity
LFT46_00785	COG0395	ABC-type sugar transport system, permease component
LFT46_00830	COG2233	PERMEase
LFT46_00835	COG0778	Nitroreductase
LFT46_00855	COG0583	DNA-binding transcription factor activity
LFT46_00870	COG2186	Transcriptional regulator
LFT46_00880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LFT46_00895	COG5416	Lipopolysaccharide assembly protein A domain
LFT46_00910	COG0154	amidase activity
LFT46_00915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LFT46_00930	COG1597	lipid kinase activity
LFT46_00935	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LFT46_00945	COG0561	phosphatase activity
LFT46_00965	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LFT46_00995	COG0037	tRNA processing
LFT46_01005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LFT46_01010	COG0302	gtp cyclohydrolase
LFT46_01020	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LFT46_01050	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LFT46_01070	COG0693	protein deglycase activity
LFT46_01075	COG2814	Major facilitator Superfamily
LFT46_01085	COG1309	transcriptional regulator
LFT46_01100	COG3665	Urea carboxylase-associated protein
LFT46_01120	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LFT46_01145	COG0823	Involved in the tonB-independent uptake of proteins
LFT46_01145	COG1506	peptidase
LFT46_01150	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LFT46_01155	COG2376	Dihydroxyacetone kinase
LFT46_01160	COG1461	Dihydroxyacetone kinase
LFT46_01165	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LFT46_01190	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LFT46_01210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LFT46_01245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LFT46_01260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LFT46_01275	COG0306	phosphate transporter
LFT46_01305	COG1609	Transcriptional regulator
LFT46_01320	COG1595	DNA-templated transcription, initiation
LFT46_01350	COG1609	Transcriptional regulator
LFT46_01360	COG0831	urea catabolic process
LFT46_01365	COG0832	Belongs to the urease beta subunit family
LFT46_01370	COG0804	urea catabolic process
LFT46_01375	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LFT46_01380	COG0830	nickel cation binding
LFT46_01385	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LFT46_01390	COG0829	nickel cation binding
LFT46_01395	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LFT46_01415	COG0395	ABC-type sugar transport system, permease component
LFT46_01440	COG3958	Transketolase
LFT46_01445	COG3959	Transketolase, thiamine diphosphate binding domain
LFT46_01450	COG0477	Major facilitator Superfamily
LFT46_01460	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_01470	COG0698	ribose 5-phosphate isomerase
LFT46_01485	COG2272	Belongs to the type-B carboxylesterase lipase family
LFT46_01515	COG1802	Transcriptional regulator
LFT46_01525	COG1175	transmembrane transport
LFT46_01530	COG0395	ABC-type sugar transport system, permease component
LFT46_01535	COG4948	Mandelate Racemase Muconate Lactonizing
LFT46_01540	COG0800	Aldolase
LFT46_01550	COG4948	Mandelate Racemase Muconate Lactonizing
LFT46_01555	COG2226	methyltransferase
LFT46_01565	COG0385	Bile acid
LFT46_01570	COG0243	molybdopterin cofactor binding
LFT46_01595	COG0697	spore germination
LFT46_01610	COG0667	Aldo Keto reductase
LFT46_01635	COG2890	protein-(glutamine-N5) methyltransferase activity
LFT46_01660	COG3401	FG-GAP repeat protein
LFT46_01665	COG0318	PFAM AMP-dependent synthetase and ligase
LFT46_01670	COG0183	Belongs to the thiolase family
LFT46_01675	COG1960	acyl-CoA dehydrogenase activity
LFT46_01680	COG1309	transcriptional regulator
LFT46_01690	COG0667	Aldo Keto reductase
LFT46_01710	COG3360	Dodecin
LFT46_01715	COG2186	Transcriptional regulator
LFT46_01725	COG2084	Dehydrogenase
LFT46_01730	COG2610	gluconate transmembrane transporter activity
LFT46_01755	COG0492	ferredoxin-NADP+ reductase activity
LFT46_01765	COG0300	oxidoreductase activity
LFT46_01775	COG0477	Major facilitator Superfamily
LFT46_01785	COG1793	dna ligase
LFT46_01785	COG3285	dna ligase
LFT46_01790	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LFT46_01810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LFT46_01810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LFT46_01810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LFT46_01815	COG1105	Belongs to the carbohydrate kinase PfkB family
LFT46_01820	COG1349	DNA-binding transcription factor activity
LFT46_01835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LFT46_01845	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LFT46_01855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LFT46_01860	COG0509	glycine decarboxylation via glycine cleavage system
LFT46_01865	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LFT46_01870	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LFT46_01870	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LFT46_01875	COG1113	amino acid transport
LFT46_01895	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LFT46_01905	COG2733	membrane
LFT46_01915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LFT46_01960	COG4122	O-methyltransferase activity
LFT46_02015	COG1191	sigma factor activity
LFT46_02020	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LFT46_02025	COG0859	PFAM glycosyl transferase family 9
LFT46_02035	COG0297	glycogen (starch) synthase activity
LFT46_02040	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LFT46_02045	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LFT46_02045	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LFT46_02050	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_02060	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LFT46_02060	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LFT46_02070	COG0583	DNA-binding transcription factor activity
LFT46_02080	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_02090	COG1733	regulation of RNA biosynthetic process
LFT46_02095	COG0702	epimerase
LFT46_02100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LFT46_02105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LFT46_02115	COG1414	Transcriptional regulator
LFT46_02120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LFT46_02145	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LFT46_02150	COG2986	histidine ammonia-lyase
LFT46_02165	COG0179	Fumarylacetoacetate (FAA) hydrolase
LFT46_02170	COG0589	response to stress
LFT46_02190	COG3290	protein histidine kinase activity
LFT46_02195	COG4565	transcriptional regulatory protein
LFT46_02200	COG0010	Belongs to the arginase family
LFT46_02205	COG3263	regulation of cellular component size
LFT46_02210	COG2252	PERMEase
LFT46_02230	COG0574	Belongs to the PEP-utilizing enzyme family
LFT46_02230	COG3848	Pyruvate phosphate dikinase
LFT46_02250	COG0791	NLP P60 protein
LFT46_02250	COG3883	PFAM NLP P60 protein
LFT46_02275	COG1796	DNA polymerase
LFT46_02275	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LFT46_02345	COG1609	Transcriptional regulator
LFT46_02375	COG0586	Pfam SNARE associated Golgi protein
LFT46_02380	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_02390	COG1278	Cold shock
LFT46_02395	COG2197	response regulator
LFT46_02410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LFT46_02420	COG2031	fatty acid transporter
LFT46_02425	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LFT46_02435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LFT46_02445	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LFT46_02470	COG0357	Ribosomal RNA small subunit methyltransferase G
LFT46_02470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LFT46_02480	COG0191	fructose-bisphosphate aldolase activity
LFT46_02510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LFT46_02530	COG1832	CoA-binding protein
LFT46_02545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LFT46_02550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LFT46_02560	COG1116	anion transmembrane transporter activity
LFT46_02565	COG1832	CoA-binding protein
LFT46_02575	COG2315	Protein conserved in bacteria
LFT46_02600	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LFT46_02605	COG0047	phosphoribosylformylglycinamidine synthase activity
LFT46_02620	COG1404	Belongs to the peptidase S8 family
LFT46_02640	COG1846	Transcriptional regulator
LFT46_02660	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LFT46_02675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LFT46_02690	COG1196	nuclear chromosome segregation
LFT46_02690	COG0741	lytic transglycosylase activity
LFT46_02690	COG0739	heme binding
LFT46_02695	COG0386	Belongs to the glutathione peroxidase family
LFT46_02700	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LFT46_02705	COG0438	transferase activity, transferring glycosyl groups
LFT46_02725	COG1309	transcriptional regulator
LFT46_02735	COG0438	transferase activity, transferring glycosyl groups
LFT46_02750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LFT46_02760	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LFT46_02770	COG1476	TRANSCRIPTIONal
LFT46_02780	COG0642	Histidine kinase
LFT46_02785	COG0745	RESPONSE REGULATOR receiver
LFT46_02790	COG0477	Major facilitator Superfamily
LFT46_02795	COG0028	Belongs to the TPP enzyme family
LFT46_02800	COG0351	phosphomethylpyrimidine kinase
LFT46_02805	COG1090	epimerase
LFT46_02830	COG0343	queuine tRNA-ribosyltransferase activity
LFT46_02870	COG1960	acyl-CoA dehydrogenase activity
LFT46_02890	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LFT46_02900	COG0586	Pfam SNARE associated Golgi protein
LFT46_02910	COG0564	pseudouridine synthase activity
LFT46_02920	COG2364	Membrane
LFT46_02925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LFT46_02930	COG1201	RNA secondary structure unwinding
LFT46_02935	COG0723	plastoquinol--plastocyanin reductase activity
LFT46_02960	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_02970	COG1609	Transcriptional regulator
LFT46_02980	COG1175	transmembrane transport
LFT46_02985	COG0395	ABC-type sugar transport system, permease component
LFT46_02995	COG0673	inositol 2-dehydrogenase activity
LFT46_03005	COG1904	glucuronate isomerase
LFT46_03010	COG0246	Mannitol dehydrogenase
LFT46_03015	COG4948	Mandelate Racemase Muconate Lactonizing
LFT46_03055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LFT46_03095	COG0671	phosphoesterase, PA-phosphatase related
LFT46_03100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LFT46_03115	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LFT46_03120	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LFT46_03130	COG2205	protein histidine kinase activity
LFT46_03135	COG0745	RESPONSE REGULATOR receiver
LFT46_03150	COG2062	phosphohistidine phosphatase, SixA
LFT46_03155	COG0583	DNA-binding transcription factor activity
LFT46_03165	COG1309	transcriptional regulator
LFT46_03170	COG1511	domain protein
LFT46_03190	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LFT46_03195	COG1017	nitric oxide dioxygenase activity
LFT46_03195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LFT46_03200	COG1959	2 iron, 2 sulfur cluster binding
LFT46_03210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LFT46_03215	COG0514	ATP-dependent DNA helicase (RecQ)
LFT46_03220	COG0477	Major facilitator Superfamily
LFT46_03235	COG1505	serine-type exopeptidase activity
LFT46_03255	COG0604	alcohol dehydrogenase
LFT46_03255	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_03255	COG3321	synthase
LFT46_03265	COG0577	efflux transmembrane transporter activity
LFT46_03265	COG1136	(ABC) transporter
LFT46_03275	COG1966	Carbon starvation protein
LFT46_03295	COG0656	L-ascorbic acid biosynthetic process
LFT46_03305	COG0584	glycerophosphoryl diester phosphodiesterase
LFT46_03330	COG1252	NADH dehydrogenase
LFT46_03360	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LFT46_03365	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LFT46_03385	COG0588	phosphoglycerate mutase activity
LFT46_03395	COG5002	protein histidine kinase activity
LFT46_03415	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LFT46_03415	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LFT46_03420	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LFT46_03425	COG0215	cysteine-tRNA ligase activity
LFT46_03430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LFT46_03450	COG0028	Belongs to the TPP enzyme family
LFT46_03460	COG0366	Alpha amylase catalytic
LFT46_03470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LFT46_03500	COG0366	Alpha amylase catalytic
LFT46_03505	COG0277	FAD linked oxidase domain protein
LFT46_03510	COG3415	Transposase
LFT46_03510	COG2801	Transposase and inactivated derivatives
LFT46_03520	COG3842	ATPase activity
LFT46_03530	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LFT46_03545	COG0582	viral genome integration into host DNA
LFT46_03555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LFT46_03595	COG3848	Pyruvate phosphate dikinase
LFT46_03595	COG0574	Belongs to the PEP-utilizing enzyme family
LFT46_03620	COG1595	DNA-templated transcription, initiation
LFT46_03655	COG1234	tRNA 3'-trailer cleavage
LFT46_03665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LFT46_03670	COG3485	protocatechuate 3,4-dioxygenase
LFT46_03675	COG4829	muconolactone delta-isomerase
LFT46_03685	COG0583	DNA-binding transcription factor activity
LFT46_03690	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LFT46_03720	COG1131	(ABC) transporter
LFT46_03745	COG2826	transposase and inactivated derivatives, IS30 family
LFT46_03755	COG0179	Fumarylacetoacetate (FAA) hydrolase
LFT46_03760	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LFT46_03765	COG2271	Major facilitator Superfamily
LFT46_03780	COG1802	Transcriptional regulator
LFT46_03835	COG0477	Major facilitator Superfamily
LFT46_03840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LFT46_03845	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LFT46_03880	COG4214	carbohydrate transport
LFT46_03885	COG1129	ABC transporter
LFT46_03890	COG4213	ABC transporter substrate-binding protein
LFT46_03905	COG2160	L-arabinose isomerase activity
LFT46_03910	COG1609	Transcriptional regulator
LFT46_03935	COG0783	Belongs to the Dps family
LFT46_03940	COG0477	Major facilitator Superfamily
LFT46_03950	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LFT46_03950	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LFT46_03955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LFT46_03990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LFT46_04005	COG1278	Cold shock
LFT46_04015	COG0459	protein refolding
LFT46_04020	COG1653	transport
LFT46_04025	COG0328	RNA-DNA hybrid ribonuclease activity
LFT46_04035	COG2205	protein histidine kinase activity
LFT46_04040	COG0745	RESPONSE REGULATOR receiver
LFT46_04060	COG1061	Type III restriction enzyme res subunit
LFT46_04075	COG1278	Cold shock
LFT46_04095	COG0739	heme binding
LFT46_04100	COG0791	NLP P60 protein
LFT46_04100	COG1388	LysM domain
LFT46_04100	COG3103	Sh3 type 3 domain protein
LFT46_04115	COG0746	molybdenum cofactor guanylyltransferase activity
LFT46_04130	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LFT46_04150	COG0488	(ABC) transporter
LFT46_04155	COG1132	(ABC) transporter
LFT46_04160	COG0494	nUDIX hydrolase
LFT46_04185	COG0483	inositol monophosphate 1-phosphatase activity
LFT46_04190	COG2801	Transposase and inactivated derivatives
LFT46_04190	COG3415	Transposase
LFT46_04215	COG2249	NAD(P)H dehydrogenase (quinone) activity
LFT46_04220	COG3415	Transposase
LFT46_04220	COG2801	Transposase and inactivated derivatives
LFT46_04230	COG0045	succinate-CoA ligase (ADP-forming) activity
LFT46_04250	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_04260	COG1082	Xylose isomerase domain protein TIM barrel
LFT46_04265	COG2376	Dihydroxyacetone kinase
LFT46_04270	COG0698	ribose 5-phosphate isomerase
LFT46_04275	COG1250	3-hydroxyacyl-CoA dehydrogenase
LFT46_04280	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_04285	COG2271	Major facilitator Superfamily
LFT46_04290	COG0149	triose-phosphate isomerase activity
LFT46_04300	COG0640	Transcriptional regulator
LFT46_04315	COG3962	Belongs to the TPP enzyme family
LFT46_04330	COG0673	inositol 2-dehydrogenase activity
LFT46_04335	COG2814	Major facilitator Superfamily
LFT46_04345	COG2814	Major facilitator Superfamily
LFT46_04350	COG3718	enzyme involved in inositol metabolism
LFT46_04355	COG2188	Transcriptional regulator
LFT46_04380	COG1396	sequence-specific DNA binding
LFT46_04395	COG0028	Belongs to the TPP enzyme family
LFT46_04405	COG0477	Major facilitator Superfamily
LFT46_04430	COG1401	restriction endodeoxyribonuclease activity
LFT46_04440	COG5002	protein histidine kinase activity
LFT46_04445	COG0745	RESPONSE REGULATOR receiver
LFT46_04455	COG4124	Belongs to the glycosyl hydrolase 26 family
LFT46_04455	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LFT46_04485	COG1902	pentaerythritol trinitrate reductase activity
LFT46_04495	COG2183	response to ionizing radiation
LFT46_04525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LFT46_04540	COG3583	domain protein
LFT46_04545	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LFT46_04550	COG0366	Alpha amylase catalytic
LFT46_04550	COG3103	Sh3 type 3 domain protein
LFT46_04555	COG1254	Belongs to the acylphosphatase family
LFT46_04570	COG0514	ATP-dependent DNA helicase (RecQ)
LFT46_04575	COG0667	Aldo Keto reductase
LFT46_04580	COG1063	alcohol dehydrogenase
LFT46_04595	COG0477	Major facilitator Superfamily
LFT46_04600	COG0412	Dienelactone hydrolase
LFT46_04610	COG1253	flavin adenine dinucleotide binding
LFT46_04620	COG0179	Fumarylacetoacetate (FAA) hydrolase
LFT46_04640	COG4948	Mandelate Racemase Muconate Lactonizing
LFT46_04645	COG2186	Transcriptional regulator
LFT46_04655	COG0640	Transcriptional regulator
LFT46_04700	COG1012	belongs to the aldehyde dehydrogenase family
LFT46_04705	COG0395	ABC-type sugar transport system, permease component
LFT46_04710	COG1175	transmembrane transport
LFT46_04720	COG3684	Belongs to the aldolase LacD family
LFT46_04730	COG0673	inositol 2-dehydrogenase activity
LFT46_04770	COG0477	Major facilitator Superfamily
LFT46_04775	COG1846	Transcriptional regulator
LFT46_04825	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LFT46_04830	COG1984	allophanate hydrolase subunit 2
LFT46_04835	COG4770	biotin carboxylase activity
LFT46_04885	COG0277	FAD linked oxidase domain protein
LFT46_04890	COG2186	Transcriptional regulator
LFT46_04895	COG1620	l-lactate permease
LFT46_04900	COG0247	lactate metabolic process
LFT46_04905	COG1139	Iron-sulfur cluster binding protein
LFT46_04910	COG1556	Lactate utilization protein
LFT46_04980	COG3383	formate dehydrogenase (NAD+) activity
LFT46_04990	COG1022	Amp-dependent synthetase and ligase
LFT46_05060	COG3848	Pyruvate phosphate dikinase
LFT46_05060	COG0574	Belongs to the PEP-utilizing enzyme family
LFT46_05085	COG0574	Belongs to the PEP-utilizing enzyme family
LFT46_05085	COG3848	Pyruvate phosphate dikinase
LFT46_05145	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LFT46_05195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LFT46_05200	COG1113	amino acid transport
LFT46_05215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LFT46_05220	COG0531	amino acid
LFT46_05225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LFT46_05250	COG1113	amino acid transport
LFT46_05290	COG1201	RNA secondary structure unwinding
LFT46_05305	COG2801	Transposase and inactivated derivatives
LFT46_05305	COG3415	Transposase
LFT46_05320	COG1484	DNA-dependent DNA replication
LFT46_05385	COG1063	alcohol dehydrogenase
LFT46_05405	COG4942	peptidase
LFT46_05425	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LFT46_05440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LFT46_05450	COG2376	Dihydroxyacetone kinase
LFT46_05455	COG0205	6-phosphofructokinase activity
LFT46_05460	COG4585	Histidine kinase
LFT46_05470	COG1063	alcohol dehydrogenase
LFT46_05495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LFT46_05520	COG1609	Transcriptional regulator
LFT46_05540	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT46_05545	COG0673	inositol 2-dehydrogenase activity
LFT46_05585	COG2350	Protein conserved in bacteria
LFT46_05590	COG1349	DNA-binding transcription factor activity
LFT46_05595	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LFT46_05600	COG3395	kinase activity
LFT46_05610	COG3619	membrane
LFT46_05615	COG0747	negative chemotaxis
LFT46_05620	COG0601	transmembrane transport
LFT46_05625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LFT46_05640	COG1802	Transcriptional regulator
LFT46_05645	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LFT46_05685	COG3540	Alkaline phosphatase
LFT46_05700	COG2072	flavoprotein involved in K transport
LFT46_05705	COG1063	alcohol dehydrogenase
LFT46_05720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LFT46_05775	COG1914	H( )-stimulated, divalent metal cation uptake system
LFT46_05790	COG1278	Cold shock
LFT46_05795	COG3794	PFAM blue (type 1) copper domain protein
LFT46_05805	COG3265	gluconokinase activity
LFT46_05810	COG2610	gluconate transmembrane transporter activity
LFT46_05835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LFT46_05850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LFT46_05860	COG3415	Transposase
LFT46_05860	COG2801	Transposase and inactivated derivatives
LFT46_05865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LFT46_05875	COG5001	Diguanylate cyclase
LFT46_05875	COG3300	MHYT domain
LFT46_05880	COG2261	transglycosylase associated protein
LFT46_05885	COG0561	phosphatase activity
LFT46_05890	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LFT46_05895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LFT46_05895	COG0438	transferase activity, transferring glycosyl groups
LFT46_05900	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
LFT46_05930	COG0477	Major facilitator Superfamily
LFT46_05935	COG0138	bifunctional purine biosynthesis protein purh
LFT46_05950	COG2838	Isocitrate dehydrogenase
LFT46_05960	COG0515	serine threonine protein kinase
LFT46_05980	COG1136	(ABC) transporter
LFT46_06000	COG2826	transposase and inactivated derivatives, IS30 family
LFT46_06005	COG2801	Transposase and inactivated derivatives
LFT46_06015	COG4213	ABC transporter substrate-binding protein
LFT46_06020	COG4214	carbohydrate transport
LFT46_06045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LFT46_06050	COG0531	amino acid
LFT46_06070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LFT46_06075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LFT46_06080	COG1131	(ABC) transporter
LFT46_06100	COG0708	Exodeoxyribonuclease III
LFT46_06105	COG0180	Tryptophanyl-tRNA synthetase
LFT46_06135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LFT46_06150	COG2009	succinate dehydrogenase
LFT46_06160	COG1473	amidohydrolase
LFT46_06160	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LFT46_06165	COG1846	Transcriptional regulator
LFT46_06170	COG1764	response to oxidative stress
LFT46_06175	COG2130	NADP-dependent
LFT46_06180	COG1744	ABC transporter substrate-binding protein PnrA-like
LFT46_06185	COG3845	ABC transporter
LFT46_06190	COG4603	Belongs to the binding-protein-dependent transport system permease family
LFT46_06195	COG1079	Belongs to the binding-protein-dependent transport system permease family
LFT46_06210	COG0586	Pfam SNARE associated Golgi protein
LFT46_06215	COG0586	Pfam SNARE associated Golgi protein
LFT46_06220	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LFT46_06225	COG3956	TIGRFAM MazG family protein
LFT46_06230	COG0148	phosphopyruvate hydratase activity
LFT46_06250	COG1404	Belongs to the peptidase S8 family
LFT46_06255	COG1252	NADH dehydrogenase
LFT46_06295	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LFT46_06305	COG2017	converts alpha-aldose to the beta-anomer
LFT46_06315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LFT46_06325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LFT46_06335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LFT46_06350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LFT46_06355	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LFT46_06380	COG0114	fumarate hydratase activity
LFT46_06385	COG0288	reversible hydration of carbon dioxide
LFT46_06395	COG1494	fructose-1,6-bisphosphatase
LFT46_06405	COG2826	transposase and inactivated derivatives, IS30 family
LFT46_06415	COG1316	TRANSCRIPTIONal
LFT46_06470	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LFT46_06525	COG0714	Associated with various cellular activities
LFT46_06530	COG0084	hydrolase, TatD family'
LFT46_06535	COG3583	domain protein
LFT46_06540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LFT46_06545	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LFT46_06550	COG0488	(ABC) transporter
LFT46_06565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LFT46_06570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LFT46_06575	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LFT46_06580	COG0193	aminoacyl-tRNA hydrolase activity
LFT46_06600	COG0822	iron-sulfur transferase activity
LFT46_06615	COG0702	epimerase
LFT46_06625	COG1988	membrane-bound metal-dependent
LFT46_06635	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LFT46_06640	COG0446	pyridine nucleotide-disulphide oxidoreductase
LFT46_06655	COG2146	nitrite reductase [NAD(P)H] activity
LFT46_06655	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LFT46_06675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LFT46_06705	COG0243	molybdopterin cofactor binding
LFT46_06710	COG2223	nitrite transmembrane transporter activity
LFT46_06715	COG0477	Major facilitator Superfamily
LFT46_06730	COG4770	biotin carboxylase activity
LFT46_06735	COG0424	maF-like protein
LFT46_06740	COG2409	Drug exporters of the RND superfamily
LFT46_06755	COG1823	symporter activity
LFT46_06770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LFT46_06780	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LFT46_06780	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LFT46_06805	COG0714	Associated with various cellular activities
LFT46_06825	COG0631	protein serine/threonine phosphatase activity
LFT46_06845	COG1674	ftsk spoiiie
LFT46_06855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LFT46_06860	COG0483	inositol monophosphate 1-phosphatase activity
LFT46_06870	COG0251	oxidation-reduction process
LFT46_06875	COG3415	Transposase
LFT46_06875	COG2801	Transposase and inactivated derivatives
LFT46_06880	COG4565	transcriptional regulatory protein
LFT46_06885	COG3290	protein histidine kinase activity
LFT46_06890	COG2851	Citrate transporter
LFT46_06895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LFT46_06900	COG0154	amidase activity
LFT46_06905	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LFT46_06920	COG1063	alcohol dehydrogenase
LFT46_06925	COG0156	8-amino-7-oxononanoate synthase activity
LFT46_06935	COG1228	amidohydrolase
LFT46_06965	COG2873	o-acetylhomoserine
LFT46_06970	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LFT46_07010	COG0400	carboxylic ester hydrolase activity
LFT46_07025	COG0423	glycine-tRNA ligase activity
LFT46_07075	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LFT46_07085	COG0358	DNA primase activity
LFT46_07110	COG2814	Major facilitator Superfamily
LFT46_07150	COG0052	Belongs to the universal ribosomal protein uS2 family
LFT46_07155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LFT46_07160	COG0528	UMP kinase activity
LFT46_07165	COG0233	cytoplasmic translational termination
LFT46_07185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LFT46_07195	COG3279	Response regulator of the LytR AlgR family
LFT46_07200	COG3275	phosphorelay sensor kinase activity
LFT46_07210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LFT46_07230	COG1522	sequence-specific DNA binding
LFT46_07240	COG0022	dehydrogenase e1 component
LFT46_07245	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT46_07255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LFT46_07265	COG1960	acyl-CoA dehydrogenase activity
LFT46_07295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LFT46_07300	COG0750	zinc metalloprotease
LFT46_07320	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LFT46_07335	COG0442	prolyl-tRNA aminoacylation
LFT46_07350	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
LFT46_07365	COG0779	Required for maturation of 30S ribosomal subunits
LFT46_07370	COG0195	Participates in both transcription termination and antitermination
LFT46_07380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LFT46_07385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LFT46_07395	COG0590	tRNA wobble adenosine to inosine editing
LFT46_07405	COG0436	Aminotransferase
LFT46_07410	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LFT46_07430	COG3483	tryptophan 2,3-dioxygenase activity
LFT46_07440	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LFT46_07445	COG1185	polyribonucleotide nucleotidyltransferase activity
LFT46_07450	COG0612	Peptidase, M16
LFT46_07490	COG0521	Mo-molybdopterin cofactor biosynthetic process
LFT46_07500	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LFT46_07530	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LFT46_07535	COG1674	ftsk spoiiie
LFT46_07545	COG1546	Belongs to the CinA family
LFT46_07545	COG1058	Belongs to the CinA family
LFT46_07550	COG1396	sequence-specific DNA binding
LFT46_07565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LFT46_07570	COG2137	regulation of response to DNA damage stimulus
LFT46_07575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LFT46_07580	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LFT46_07585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LFT46_07590	COG2813	Specifically methylates the guanine in position
LFT46_07595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LFT46_07605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LFT46_07615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LFT46_07620	COG0131	Imidazoleglycerol-phosphate dehydratase
LFT46_07625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LFT46_07635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LFT46_07655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LFT46_07660	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LFT46_07665	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LFT46_07680	COG2814	Major facilitator Superfamily
LFT46_07705	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LFT46_07710	COG0072	phenylalanine-tRNA ligase activity
LFT46_07710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LFT46_07720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LFT46_07725	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LFT46_07730	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LFT46_07735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LFT46_07740	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LFT46_07745	COG1438	arginine binding
LFT46_07750	COG0137	argininosuccinate synthase activity
LFT46_07755	COG0165	Argininosuccinate lyase
LFT46_07760	COG0259	pyridoxamine-phosphate oxidase activity
LFT46_07780	COG2094	Belongs to the DNA glycosylase MPG family
LFT46_07785	COG3973	AAA domain
LFT46_07790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LFT46_07820	COG0647	UMP catabolic process
LFT46_07835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LFT46_07840	COG0497	DNA recombination
LFT46_07845	COG0504	CTP synthase activity
LFT46_07850	COG0494	nUDIX hydrolase
LFT46_07880	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LFT46_07885	COG2079	MmgE PrpD family protein
LFT46_07905	COG3290	protein histidine kinase activity
LFT46_07910	COG1301	dicarboxylic acid transport
LFT46_07920	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LFT46_07925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LFT46_07940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LFT46_07950	COG1160	GTP binding
LFT46_07965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LFT46_07970	COG0509	glycine decarboxylation via glycine cleavage system
LFT46_07995	COG1192	Involved in chromosome partitioning
LFT46_08000	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LFT46_08010	COG1940	carbohydrate kinase activity
LFT46_08035	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LFT46_08040	COG0515	serine threonine protein kinase
LFT46_08040	COG2815	serine threonine protein kinase
LFT46_08045	COG3942	CHAP domain
LFT46_08045	COG1388	LysM domain
LFT46_08055	COG0142	geranyltranstransferase activity
LFT46_08065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LFT46_08075	COG2001	Belongs to the MraZ family
LFT46_08080	COG0275	rRNA processing
LFT46_08090	COG0768	penicillin binding
LFT46_08095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LFT46_08105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LFT46_08110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LFT46_08115	COG0772	Belongs to the SEDS family
LFT46_08120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LFT46_08125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LFT46_08135	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LFT46_08140	COG1496	oxidoreductase activity
LFT46_08150	COG1799	cell septum assembly
LFT46_08160	COG3599	regulation of cell shape
LFT46_08165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LFT46_08175	COG0587	DNA-directed DNA polymerase activity
LFT46_08190	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LFT46_08195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LFT46_08215	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LFT46_08220	COG0174	glutamine synthetase
LFT46_08225	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LFT46_08260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LFT46_08265	COG0321	lipoyl(octanoyl) transferase activity
LFT46_08270	COG0515	serine threonine protein kinase
LFT46_08270	COG2815	serine threonine protein kinase
LFT46_08275	COG1090	epimerase
LFT46_08280	COG0793	Belongs to the peptidase S41A family
LFT46_08280	COG4946	Tricorn protease homolog
LFT46_08285	COG1764	response to oxidative stress
LFT46_08295	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT46_08300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LFT46_08305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LFT46_08325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LFT46_08335	COG0187	DNA topoisomerase II activity
LFT46_08355	COG1271	oxidase subunit
LFT46_08360	COG1294	oxidase, subunit
LFT46_08365	COG4988	ABC transporter
LFT46_08375	COG1131	(ABC) transporter
LFT46_08385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LFT46_08390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LFT46_08390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LFT46_08405	COG1435	thymidine kinase activity
LFT46_08435	COG0756	dUTP diphosphatase activity
LFT46_08460	COG0569	domain protein
LFT46_08465	COG0531	amino acid
LFT46_08470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LFT46_08475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LFT46_08480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LFT46_08495	COG0667	Aldo Keto reductase
LFT46_08515	COG1122	ATPase activity
LFT46_08520	COG1024	Enoyl-CoA hydratase
LFT46_08520	COG1250	3-hydroxyacyl-CoA dehydrogenase
LFT46_08525	COG0183	Belongs to the thiolase family
LFT46_08555	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LFT46_08575	COG0300	oxidoreductase activity
LFT46_08600	COG3135	benzoate transporter
LFT46_08645	COG0242	peptide deformylase activity
LFT46_08650	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LFT46_08660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LFT46_08675	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LFT46_08675	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LFT46_08685	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LFT46_08690	COG0140	phosphoribosyl-ATP diphosphatase activity
LFT46_08695	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LFT46_08700	COG0107	imidazoleglycerol-phosphate synthase activity
LFT46_08710	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LFT46_08730	COG0134	indole-3-glycerol-phosphate synthase activity
LFT46_08735	COG0133	tryptophan synthase activity
LFT46_08740	COG0159	tryptophan synthase activity
LFT46_08750	COG0067	glutamate synthase
LFT46_08750	COG0070	glutamate synthase
LFT46_08750	COG0069	glutamate synthase activity
LFT46_08800	COG3189	MarR family transcriptional regulator
LFT46_08805	COG3387	PFAM Glycoside hydrolase 15-related
LFT46_08820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LFT46_08830	COG0302	gtp cyclohydrolase
LFT46_08910	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LFT46_08920	COG2814	Major facilitator Superfamily
LFT46_08925	COG3387	PFAM Glycoside hydrolase 15-related
LFT46_08930	COG0300	oxidoreductase activity
LFT46_08965	COG0028	Belongs to the TPP enzyme family
LFT46_08975	COG3387	PFAM Glycoside hydrolase 15-related
LFT46_08995	COG2017	converts alpha-aldose to the beta-anomer
LFT46_09000	COG1063	alcohol dehydrogenase
LFT46_09005	COG1295	ribonuclease BN
LFT46_09040	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LFT46_09060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LFT46_09070	COG3300	MHYT domain
LFT46_09070	COG5001	Diguanylate cyclase
LFT46_09075	COG0789	Transcriptional regulator
LFT46_09130	COG2826	transposase and inactivated derivatives, IS30 family
LFT46_09155	COG1309	transcriptional regulator
LFT46_09185	COG1126	abc transporter atp-binding protein
LFT46_09190	COG0765	amino acid transport
LFT46_09195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LFT46_09200	COG0640	Transcriptional regulator
LFT46_09225	COG2814	Major facilitator Superfamily
LFT46_09225	COG0477	Major facilitator Superfamily
LFT46_09240	COG2159	amidohydrolase
LFT46_09250	COG2186	Transcriptional regulator
LFT46_09265	COG0277	FAD linked oxidase domain protein
LFT46_09270	COG1620	l-lactate permease
LFT46_09275	COG1268	BioY protein
LFT46_09295	COG2249	NAD(P)H dehydrogenase (quinone) activity
LFT46_09300	COG2267	carboxylic ester hydrolase activity
LFT46_09345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LFT46_09360	COG2340	Cysteine-rich secretory protein family
LFT46_09375	COG3387	PFAM Glycoside hydrolase 15-related
LFT46_09395	COG0028	Belongs to the TPP enzyme family
LFT46_09420	COG2017	converts alpha-aldose to the beta-anomer
LFT46_09425	COG1063	alcohol dehydrogenase
LFT46_09450	COG0437	4 iron, 4 sulfur cluster binding
LFT46_09460	COG0709	Synthesizes selenophosphate from selenide and ATP
LFT46_09495	COG1063	alcohol dehydrogenase
LFT46_09505	COG2124	cytochrome p450
LFT46_09525	COG3458	cephalosporin-C deacetylase activity
LFT46_09530	COG1472	Belongs to the glycosyl hydrolase 3 family
LFT46_09535	COG0395	ABC-type sugar transport system, permease component
LFT46_09540	COG1175	transmembrane transport
LFT46_09545	COG1653	transport
LFT46_09555	COG2755	lipolytic protein G-D-S-L family
LFT46_09555	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LFT46_09565	COG0667	Aldo Keto reductase
LFT46_09575	COG2268	Band 7 protein
LFT46_09585	COG0477	Major facilitator Superfamily
LFT46_09590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LFT46_09600	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_09615	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LFT46_09630	COG0406	alpha-ribazole phosphatase activity
LFT46_09635	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LFT46_09660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LFT46_09665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LFT46_09680	COG1643	Atp-dependent helicase
LFT46_09695	COG0009	L-threonylcarbamoyladenylate synthase
LFT46_09740	COG2050	protein possibly involved in aromatic compounds catabolism
LFT46_09750	COG4552	Acetyltransferase involved in intracellular survival and related
LFT46_09755	COG0539	negative regulation of cytoplasmic translation
LFT46_09765	COG1739	Uncharacterized protein family UPF0029
LFT46_09775	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LFT46_09775	COG0237	dephospho-CoA kinase activity
LFT46_09780	COG0556	nucleotide-excision repair
LFT46_09785	COG1653	transport
LFT46_09795	COG0477	Major facilitator Superfamily
LFT46_09815	COG4106	trans-aconitate 2-methyltransferase activity
LFT46_09845	COG0204	Acyl-transferase
LFT46_09845	COG0318	PFAM AMP-dependent synthetase and ligase
LFT46_09850	COG0322	excinuclease ABC activity
LFT46_09855	COG1660	Displays ATPase and GTPase activities
LFT46_09860	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LFT46_09865	COG1481	regulation of sporulation
LFT46_09870	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LFT46_09875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LFT46_09880	COG0126	phosphoglycerate kinase activity
LFT46_09885	COG0149	triose-phosphate isomerase activity
LFT46_09890	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LFT46_09900	COG0363	glucosamine-6-phosphate deaminase activity
LFT46_09915	COG0166	Belongs to the GPI family
LFT46_09920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LFT46_09925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LFT46_09930	COG0109	protoheme IX farnesyltransferase activity
LFT46_09940	COG1612	heme a metabolic process
LFT46_09950	COG1131	(ABC) transporter
LFT46_09975	COG0396	ATPase activity
LFT46_09980	COG2151	metal-sulfur cluster biosynthetic enzyme
LFT46_09990	COG0318	PFAM AMP-dependent synthetase and ligase
LFT46_10005	COG1122	ATPase activity
LFT46_10010	COG1268	BioY protein
LFT46_10045	COG2826	transposase and inactivated derivatives, IS30 family
LFT46_10110	COG1309	transcriptional regulator
LFT46_10115	COG1250	3-hydroxyacyl-CoA dehydrogenase
LFT46_10120	COG0346	lactoylglutathione lyase activity
LFT46_10125	COG2354	Protein conserved in bacteria
LFT46_10135	COG0488	(ABC) transporter
LFT46_10160	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_10165	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_10170	COG0560	Phosphoserine phosphatase
LFT46_10170	COG3830	Belongs to the UPF0237 family
LFT46_10175	COG1119	ATPase activity
LFT46_10190	COG0254	rRNA binding
LFT46_10205	COG2855	membrane
LFT46_10220	COG1305	Transglutaminase-like
LFT46_10235	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LFT46_10240	COG0297	glycogen (starch) synthase activity
LFT46_10260	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_10280	COG0435	Glutathione S-transferase
LFT46_10340	COG1404	Belongs to the peptidase S8 family
LFT46_10350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LFT46_10370	COG0667	Aldo Keto reductase
LFT46_10375	COG1968	undecaprenyl-diphosphatase activity
LFT46_10380	COG0215	cysteine-tRNA ligase activity
LFT46_10390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LFT46_10395	COG1994	Peptidase M50
LFT46_10395	COG0517	IMP dehydrogenase activity
LFT46_10405	COG1222	aaa ATPase
LFT46_10410	COG4122	O-methyltransferase activity
LFT46_10420	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LFT46_10425	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LFT46_10430	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LFT46_10435	COG0545	Peptidyl-prolyl cis-trans isomerase
LFT46_10455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LFT46_10460	COG0805	protein transport
LFT46_10465	COG4581	dead DEAH box helicase
LFT46_10470	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LFT46_10475	COG1216	Glycosyl transferase, family 2
LFT46_10500	COG0242	peptide deformylase activity
LFT46_10510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LFT46_10520	COG3424	synthase
LFT46_10525	COG4974	Belongs to the 'phage' integrase family
LFT46_10555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LFT46_10560	COG1845	cytochrome c oxidase, subunit III
LFT46_10565	COG2010	Cytochrome c
LFT46_10570	COG0723	plastoquinol--plastocyanin reductase activity
LFT46_10575	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LFT46_10595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LFT46_10600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LFT46_10620	COG0167	dihydroorotate dehydrogenase activity
LFT46_10630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LFT46_10635	COG1381	Involved in DNA repair and RecF pathway recombination
LFT46_10640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LFT46_10645	COG3590	peptidase
LFT46_10650	COG1316	TRANSCRIPTIONal
LFT46_10655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LFT46_10665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LFT46_10680	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LFT46_10685	COG0484	heat shock protein binding
LFT46_10690	COG1420	regulation of RNA biosynthetic process
LFT46_10710	COG0481	GTPase activity
LFT46_10720	COG0268	Binds directly to 16S ribosomal RNA
LFT46_10735	COG1555	photosystem II stabilization
LFT46_10740	COG3152	Membrane
LFT46_10750	COG1307	EDD domain protein, DegV family
LFT46_10755	COG0495	leucyl-tRNA aminoacylation
LFT46_10760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LFT46_10765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LFT46_10770	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LFT46_10775	COG2390	Transcriptional regulator
LFT46_10780	COG0656	L-ascorbic acid biosynthetic process
LFT46_10790	COG0438	transferase activity, transferring glycosyl groups
LFT46_10800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LFT46_10810	COG1758	RNA polymerase activity
LFT46_10815	COG0194	GDP metabolic process
LFT46_10820	COG0194	GDP metabolic process
LFT46_10825	COG0284	orotidine-5'-phosphate decarboxylase activity
LFT46_10830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LFT46_10835	COG0505	Belongs to the CarA family
LFT46_10845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LFT46_10850	COG0540	Belongs to the ATCase OTCase family
LFT46_10855	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LFT46_10865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LFT46_10870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LFT46_10880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LFT46_10890	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LFT46_10895	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LFT46_10910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LFT46_10925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LFT46_10945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LFT46_10955	COG0124	histidyl-tRNA synthetase
LFT46_10960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LFT46_10965	COG1196	nuclear chromosome segregation
LFT46_10975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LFT46_10980	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LFT46_10985	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LFT46_10995	COG2255	four-way junction helicase activity
LFT46_11000	COG0632	four-way junction helicase activity
LFT46_11005	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LFT46_11010	COG0217	transcriptional regulatory protein
LFT46_11015	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LFT46_11020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LFT46_11030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LFT46_11035	COG0339	signal peptide processing
LFT46_11040	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LFT46_11045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LFT46_11055	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LFT46_11060	COG0587	DNA-directed DNA polymerase activity
LFT46_11075	COG0077	Prephenate dehydratase
LFT46_11075	COG1605	Chorismate mutase
LFT46_11085	COG2135	peptidase activity
LFT46_11100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LFT46_11105	COG1695	Transcriptional regulator
LFT46_11135	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_11160	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LFT46_11165	COG1234	tRNA 3'-trailer cleavage
LFT46_11265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LFT46_11265	COG0574	Belongs to the PEP-utilizing enzyme family
LFT46_11270	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LFT46_11280	COG2217	Heavy metal translocating P-type atpase
LFT46_11380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LFT46_11395	COG0464	growth
LFT46_11400	COG1842	Phage shock protein A
LFT46_11405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT46_11420	COG0483	inositol monophosphate 1-phosphatase activity
LFT46_11450	COG1695	Transcriptional regulator
LFT46_11490	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LFT46_11500	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LFT46_11525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LFT46_11530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LFT46_11535	COG1780	Probably involved in ribonucleotide reductase function
LFT46_11550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LFT46_11565	COG0583	DNA-binding transcription factor activity
LFT46_11580	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LFT46_11610	COG0714	Associated with various cellular activities
LFT46_11625	COG1175	transmembrane transport
LFT46_11630	COG2182	Extracellular solute-binding protein
LFT46_11640	COG2813	Specifically methylates the guanine in position
LFT46_11645	COG0492	ferredoxin-NADP+ reductase activity
LFT46_11650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LFT46_11655	COG2801	Transposase and inactivated derivatives
LFT46_11655	COG3415	Transposase
LFT46_11680	COG0799	negative regulation of ribosome biogenesis
LFT46_11690	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LFT46_11700	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LFT46_11705	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LFT46_11710	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LFT46_11715	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LFT46_11720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LFT46_11725	COG0352	thiamine-phosphate diphosphorylase activity
LFT46_11725	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LFT46_11725	COG0351	phosphomethylpyrimidine kinase
LFT46_11730	COG1530	ribonuclease E activity
LFT46_11740	COG0105	UTP biosynthetic process
LFT46_11750	COG0285	dihydrofolate synthase activity
LFT46_11755	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LFT46_11765	COG3189	MarR family transcriptional regulator
LFT46_11770	COG0525	valine-tRNA ligase activity
LFT46_11775	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LFT46_11780	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LFT46_11785	COG0740	serine-type endopeptidase activity
LFT46_11790	COG0740	serine-type endopeptidase activity
LFT46_11795	COG0544	peptidyl-prolyl cis-trans isomerase activity
LFT46_11840	COG0668	transmembrane transport
LFT46_11855	COG1946	Acyl-CoA thioesterase
LFT46_11860	COG2801	Transposase and inactivated derivatives
LFT46_11860	COG3415	Transposase
LFT46_11890	COG2115	Belongs to the xylose isomerase family
LFT46_11895	COG1070	Carbohydrate kinase
LFT46_11910	COG0673	inositol 2-dehydrogenase activity
LFT46_11915	COG1609	Transcriptional regulator
LFT46_11920	COG0657	acetylesterase activity
LFT46_11920	COG2755	lipolytic protein G-D-S-L family
LFT46_11925	COG2017	converts alpha-aldose to the beta-anomer
LFT46_11940	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LFT46_11950	COG0242	peptide deformylase activity
LFT46_11980	COG3022	response to hydroperoxide
LFT46_11990	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LFT46_11995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LFT46_12005	COG1045	serine acetyltransferase
LFT46_12010	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LFT46_12045	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LFT46_12060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LFT46_12065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LFT46_12080	COG4974	Belongs to the 'phage' integrase family
LFT46_12095	COG0792	nuclease activity
LFT46_12105	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LFT46_12115	COG0681	Belongs to the peptidase S26 family
LFT46_12120	COG0335	large ribosomal subunit rRNA binding
LFT46_12125	COG0336	Belongs to the RNA methyltransferase TrmD family
LFT46_12130	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LFT46_12135	COG1837	Belongs to the UPF0109 family
LFT46_12140	COG0228	four-way junction DNA binding
LFT46_12150	COG2514	catechol 2,3-dioxygenase activity
LFT46_12175	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LFT46_12180	COG2801	Transposase and inactivated derivatives
LFT46_12180	COG3415	Transposase
LFT46_12195	COG2814	Major facilitator Superfamily
LFT46_12210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LFT46_12215	COG0318	PFAM AMP-dependent synthetase and ligase
LFT46_12220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LFT46_12225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LFT46_12230	COG0571	ribonuclease III activity
LFT46_12235	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LFT46_12245	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LFT46_12260	COG0742	ribosomal rna small subunit methyltransferase
LFT46_12265	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LFT46_12270	COG1461	Dihydroxyacetone kinase
LFT46_12285	COG1181	Belongs to the D-alanine--D-alanine ligase family
LFT46_12290	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LFT46_12300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LFT46_12305	COG0066	3-isopropylmalate dehydratase activity
LFT46_12310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LFT46_12315	COG1414	Transcriptional regulator
LFT46_12325	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LFT46_12355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LFT46_12360	COG0179	Fumarylacetoacetate (FAA) hydrolase
LFT46_12365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LFT46_12375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LFT46_12380	COG0473	3-isopropylmalate dehydrogenase activity
LFT46_12385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LFT46_12390	COG1136	(ABC) transporter
LFT46_12390	COG0577	efflux transmembrane transporter activity
LFT46_12405	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LFT46_12410	COG0440	acetolactate synthase activity
LFT46_12420	COG0129	dihydroxy-acid dehydratase activity
LFT46_12425	COG0088	Forms part of the polypeptide exit tunnel
LFT46_12460	COG0747	negative chemotaxis
LFT46_12465	COG0579	oxidoreductase
LFT46_12470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LFT46_12475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT46_12485	COG1305	Transglutaminase-like
LFT46_12505	COG1104	cysteine desulfurase activity
LFT46_12515	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LFT46_12520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LFT46_12530	COG1113	amino acid transport
LFT46_12545	COG0477	Major facilitator Superfamily
LFT46_12560	COG0419	ATPase involved in DNA repair
LFT46_12565	COG0420	3'-5' exonuclease activity
LFT46_12590	COG0586	Pfam SNARE associated Golgi protein
LFT46_12595	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LFT46_12600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LFT46_12605	COG1234	tRNA 3'-trailer cleavage
LFT46_12610	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LFT46_12620	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LFT46_12630	COG1335	isochorismatase
LFT46_12645	COG0363	glucosamine-6-phosphate deaminase activity
LFT46_12670	COG1902	pentaerythritol trinitrate reductase activity
LFT46_12685	COG0628	permease
LFT46_12700	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LFT46_12710	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LFT46_12715	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LFT46_12725	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LFT46_12730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LFT46_12735	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LFT46_12740	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LFT46_12745	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LFT46_12750	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LFT46_12755	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LFT46_12760	COG0356	it plays a direct role in the translocation of protons across the membrane
LFT46_12795	COG2890	protein-(glutamine-N5) methyltransferase activity
LFT46_12800	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LFT46_12810	COG0083	homoserine kinase activity
LFT46_12815	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LFT46_12820	COG0460	homoserine dehydrogenase
LFT46_12825	COG0019	diaminopimelate decarboxylase activity
LFT46_12830	COG0018	arginyl-trna synthetase
LFT46_12845	COG1017	nitric oxide dioxygenase activity
LFT46_12845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LFT46_12870	COG1643	Atp-dependent helicase
LFT46_12875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LFT46_12880	COG0537	adenosine 5'-monophosphoramidase activity
LFT46_12885	COG1064	alcohol dehydrogenase
LFT46_12895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LFT46_12900	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LFT46_12915	COG1121	(ABC) transporter
LFT46_12920	COG0803	Belongs to the bacterial solute-binding protein 9 family
LFT46_12935	COG0567	Dehydrogenase, E1 component
LFT46_12935	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT46_12960	COG1595	DNA-templated transcription, initiation
LFT46_12970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LFT46_12980	COG0483	inositol monophosphate 1-phosphatase activity
LFT46_12985	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LFT46_13000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LFT46_13005	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LFT46_13015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LFT46_13025	COG1063	alcohol dehydrogenase
LFT46_13060	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LFT46_13060	COG2755	lipolytic protein G-D-S-L family
LFT46_13075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LFT46_13090	COG2884	Cell division ATP-binding protein ftsE
LFT46_13095	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LFT46_13145	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LFT46_13150	COG1088	dTDP-glucose 4,6-dehydratase activity
LFT46_13180	COG1215	transferase activity, transferring glycosyl groups
LFT46_13210	COG1216	Glycosyl transferase, family 2
LFT46_13240	COG2902	Dehydrogenase
LFT46_13275	COG0653	protein targeting
LFT46_13280	COG3214	Protein conserved in bacteria
LFT46_13285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LFT46_13295	COG5401	PFAM Sporulation and spore germination
LFT46_13300	COG5002	protein histidine kinase activity
LFT46_13325	COG0714	Associated with various cellular activities
LFT46_13360	COG0601	transmembrane transport
LFT46_13370	COG0482	sulfurtransferase activity
LFT46_13395	COG0484	heat shock protein binding
LFT46_13400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LFT46_13420	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LFT46_13425	COG2086	electron transfer activity
LFT46_13430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LFT46_13440	COG1842	Phage shock protein A
LFT46_13445	COG0415	Belongs to the DNA photolyase family
LFT46_13465	COG1615	UPF0182 protein
LFT46_13490	COG2816	NAD+ diphosphatase activity
LFT46_13500	COG0210	DNA helicase
LFT46_13520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LFT46_13525	COG0765	amino acid transport
LFT46_13530	COG1126	abc transporter atp-binding protein
LFT46_13535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LFT46_13555	COG0181	hydroxymethylbilane synthase activity
LFT46_13560	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LFT46_13565	COG3253	May function as heme-dependent peroxidase
LFT46_13580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LFT46_13585	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LFT46_13610	COG2022	thiamine diphosphate biosynthetic process
LFT46_13620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LFT46_13625	COG0352	thiamine-phosphate diphosphorylase activity
LFT46_13630	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LFT46_13635	COG0513	Belongs to the DEAD box helicase family
LFT46_13640	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LFT46_13645	COG0613	PHP domain protein
LFT46_13650	COG0006	proline dipeptidase activity
LFT46_13660	COG2239	Acts as a magnesium transporter
LFT46_13675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LFT46_13685	COG1595	DNA-templated transcription, initiation
LFT46_13715	COG1126	abc transporter atp-binding protein
LFT46_13725	COG0765	amino acid transport
LFT46_13730	COG0765	amino acid transport
LFT46_13735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LFT46_13740	COG2171	N-acyltransferase activity
LFT46_13755	COG3226	Transcriptional regulator
LFT46_13760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LFT46_13785	COG1217	gtp-binding protein TYPA
LFT46_13800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LFT46_13810	COG4166	transmembrane transport
LFT46_13825	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT46_13825	COG0596	Alpha beta hydrolase
LFT46_13830	COG0012	GTP binding
LFT46_13835	COG1322	Protein conserved in bacteria
LFT46_13840	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LFT46_13850	COG1570	exodeoxyribonuclease VII activity
LFT46_13855	COG1722	exodeoxyribonuclease VII activity
LFT46_13860	COG2326	polyphosphate kinase activity
LFT46_13875	COG1174	glycine betaine transport
LFT46_13880	COG1174	glycine betaine transport
LFT46_13895	COG2971	BadF BadG BcrA BcrD
LFT46_13900	COG0583	DNA-binding transcription factor activity
LFT46_13905	COG2814	Major facilitator Superfamily
LFT46_13910	COG1522	sequence-specific DNA binding
LFT46_13925	COG0598	Magnesium transport protein CorA
LFT46_13955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LFT46_13960	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LFT46_13980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LFT46_13980	COG0519	Catalyzes the synthesis of GMP from XMP
LFT46_14000	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LFT46_14005	COG0516	GMP reductase activity
LFT46_14045	COG1793	dna ligase
LFT46_14055	COG0459	protein refolding
LFT46_14060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LFT46_14075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LFT46_14080	COG1472	Belongs to the glycosyl hydrolase 3 family
LFT46_14085	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LFT46_14095	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LFT46_14110	COG0802	atpase or kinase
LFT46_14115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LFT46_14125	COG1486	melibiose metabolic process
LFT46_14130	COG0438	transferase activity, transferring glycosyl groups
LFT46_14135	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LFT46_14150	COG0667	Aldo Keto reductase
LFT46_14175	COG0736	holo-[acyl-carrier-protein] synthase activity
LFT46_14190	COG1072	(Pantothenic acid kinase))
LFT46_14195	COG1876	peptidase activity
LFT46_14200	COG1970	mechanosensitive ion channel activity
LFT46_14205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LFT46_14210	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LFT46_14215	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LFT46_14245	COG0455	bacterial-type flagellum organization
LFT46_14285	COG2894	cell division
LFT46_14310	COG0745	RESPONSE REGULATOR receiver
LFT46_14320	COG0101	tRNA pseudouridine synthase activity
LFT46_14325	COG0203	ribosomal protein L17
LFT46_14330	COG0202	RNA polymerase activity
LFT46_14335	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LFT46_14340	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LFT46_14345	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LFT46_14350	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LFT46_14355	COG3191	aminopeptidase activity
LFT46_14360	COG1175	transmembrane transport
LFT46_14380	COG0563	adenylate kinase activity
LFT46_14390	COG0200	Binds to the 23S rRNA
LFT46_14395	COG1841	ribosomal large subunit assembly
LFT46_14400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LFT46_14405	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LFT46_14410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LFT46_14415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LFT46_14420	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LFT46_14425	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LFT46_14430	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LFT46_14435	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LFT46_14445	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LFT46_14450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LFT46_14455	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LFT46_14460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LFT46_14465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LFT46_14470	COG0089	rRNA binding
LFT46_14475	COG0088	Forms part of the polypeptide exit tunnel
LFT46_14480	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LFT46_14485	COG0051	transcription antitermination factor activity, RNA binding
LFT46_14490	COG2723	6-phospho-beta-galactosidase activity
LFT46_14500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LFT46_14505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LFT46_14510	COG0049	tRNA binding
LFT46_14515	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LFT46_14520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LFT46_14525	COG0085	RNA polymerase activity
LFT46_14535	COG0183	Belongs to the thiolase family
LFT46_14540	COG0442	prolyl-tRNA aminoacylation
LFT46_14545	COG0222	ribosome binding
LFT46_14550	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LFT46_14565	COG0081	regulation of translation
LFT46_14570	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LFT46_14590	COG0436	Aminotransferase
LFT46_14595	COG2197	response regulator
LFT46_14640	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LFT46_14645	COG3485	protocatechuate 3,4-dioxygenase
LFT46_14655	COG0745	RESPONSE REGULATOR receiver
LFT46_14660	COG0456	acetyltransferase
LFT46_14665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LFT46_14680	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LFT46_14710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LFT46_14725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LFT46_14730	COG0738	Major facilitator superfamily
LFT46_14740	COG2030	dehydratase
LFT46_14760	COG4989	oxidoreductase activity
LFT46_14765	COG0366	Alpha amylase catalytic
LFT46_14770	COG1940	carbohydrate kinase activity
LFT46_14775	COG0702	epimerase
LFT46_14785	COG1140	nitrate reductase beta subunit
LFT46_14810	COG0706	membrane insertase activity
LFT46_14840	COG0754	glutathionylspermidine amidase activity
LFT46_14850	COG1960	acyl-CoA dehydrogenase activity
LFT46_14880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LFT46_14900	COG0318	PFAM AMP-dependent synthetase and ligase
LFT46_14910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LFT46_14945	COG1666	GTP binding
LFT46_14960	COG2837	iron assimilation
LFT46_14965	COG0501	Belongs to the peptidase M48B family
LFT46_14990	COG0531	amino acid
LFT46_15030	COG1012	belongs to the aldehyde dehydrogenase family
LFT46_15035	COG3835	regulator
LFT46_15050	COG2186	Transcriptional regulator
LFT46_15095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LFT46_15095	COG1116	anion transmembrane transporter activity
LFT46_15105	COG1690	Belongs to the RtcB family
LFT46_15115	COG2895	sulfate adenylyltransferase (ATP) activity
LFT46_15125	COG0175	sulfate reduction
LFT46_15130	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LFT46_15140	COG2860	membrane
LFT46_15160	COG0142	geranyltranstransferase activity
LFT46_15170	COG2226	methyltransferase
LFT46_15175	COG1169	isochorismate synthase
LFT46_15185	COG0765	amino acid transport
LFT46_15190	COG1126	abc transporter atp-binding protein
LFT46_15195	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LFT46_15210	COG4948	Mandelate Racemase Muconate Lactonizing
LFT46_15215	COG1914	H( )-stimulated, divalent metal cation uptake system
LFT46_15220	COG0598	Magnesium transport protein CorA
LFT46_15230	COG3559	Exporter of polyketide antibiotics
LFT46_15235	COG1131	(ABC) transporter
LFT46_15255	COG1309	transcriptional regulator
LFT46_15270	COG2072	flavoprotein involved in K transport
LFT46_15310	COG0492	ferredoxin-NADP+ reductase activity
LFT46_15315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LFT46_15350	COG1316	TRANSCRIPTIONal
LFT46_15370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LFT46_15370	COG2755	lipolytic protein G-D-S-L family
LFT46_15390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LFT46_15395	COG1404	Belongs to the peptidase S8 family
LFT46_15415	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT46_15420	COG0022	dehydrogenase e1 component
LFT46_15455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LFT46_15465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LFT46_15505	COG1597	lipid kinase activity
LFT46_15515	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LFT46_15520	COG0142	geranyltranstransferase activity
LFT46_15560	COG2721	sulfolactate sulfo-lyase activity
LFT46_15575	COG2814	Major facilitator Superfamily
LFT46_15585	COG1414	Transcriptional regulator
LFT46_15610	COG0765	amino acid transport
LFT46_15620	COG1304	FMN binding
LFT46_15680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LFT46_15690	COG0297	glycogen (starch) synthase activity
LFT46_15690	COG0438	transferase activity, transferring glycosyl groups
LFT46_15740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LFT46_15750	COG0489	protein tyrosine kinase activity
LFT46_15770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LFT46_15775	COG1024	Enoyl-CoA hydratase
LFT46_15780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LFT46_15785	COG2151	metal-sulfur cluster biosynthetic enzyme
LFT46_15790	COG3396	Phenylacetate-CoA oxygenase
LFT46_15795	COG3460	Phenylacetate-CoA oxygenase
LFT46_15800	COG3396	Phenylacetate-CoA oxygenase
LFT46_15830	COG0671	phosphoesterase, PA-phosphatase related
LFT46_15845	COG5002	protein histidine kinase activity
LFT46_15855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LFT46_15910	COG0667	Aldo Keto reductase
LFT46_15915	COG0300	oxidoreductase activity
LFT46_15940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LFT46_15950	COG0640	Transcriptional regulator
LFT46_15965	COG1247	-acetyltransferase
LFT46_15980	COG0390	transport system, permease component
LFT46_16030	COG1937	Protein conserved in bacteria
LFT46_16035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LFT46_16050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LFT46_16075	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT46_16085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LFT46_16090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LFT46_16125	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LFT46_16180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LFT46_16185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LFT46_16200	COG3842	ATPase activity
LFT46_16210	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LFT46_16240	COG2217	Heavy metal translocating P-type atpase
LFT46_16255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LFT46_16265	COG1316	TRANSCRIPTIONal
LFT46_16275	COG0588	phosphoglycerate mutase activity
LFT46_16280	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LFT46_16285	COG0071	Belongs to the small heat shock protein (HSP20) family
LFT46_16325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LFT46_16345	COG2826	transposase and inactivated derivatives, IS30 family
LFT46_16350	COG0857	belongs to the CobB CobQ family
LFT46_16350	COG0280	phosphate acetyltransferase
LFT46_16355	COG2050	protein possibly involved in aromatic compounds catabolism
LFT46_16375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LFT46_16390	COG1012	belongs to the aldehyde dehydrogenase family
LFT46_16390	COG2030	dehydratase
LFT46_16395	COG2050	protein possibly involved in aromatic compounds catabolism
LFT46_16415	COG2755	lipolytic protein G-D-S-L family
LFT46_16430	COG1250	3-hydroxyacyl-CoA dehydrogenase
LFT46_16435	COG1024	Enoyl-CoA hydratase
LFT46_16440	COG0183	Belongs to the thiolase family
LFT46_16470	COG1266	CAAX protease self-immunity
LFT46_16480	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LFT46_16530	COG0443	Heat shock 70 kDa protein
LFT46_16535	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LFT46_16545	COG0785	Cytochrome C biogenesis protein
LFT46_16550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LFT46_16555	COG0406	alpha-ribazole phosphatase activity
LFT46_16560	COG2353	YceI-like domain
LFT46_16570	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LFT46_16595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LFT46_16605	COG3458	cephalosporin-C deacetylase activity
LFT46_16610	COG1070	Carbohydrate kinase
LFT46_16615	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_16615	COG3347	Dehydrogenase
LFT46_16630	COG1609	Transcriptional regulator
LFT46_16650	COG2755	lipolytic protein G-D-S-L family
LFT46_16655	COG0395	ABC-type sugar transport system, permease component
LFT46_16660	COG4209	transmembrane transport
LFT46_16665	COG1653	transport
LFT46_16670	COG5578	integral membrane protein
LFT46_16675	COG0673	inositol 2-dehydrogenase activity
LFT46_16685	COG2814	Major facilitator Superfamily
LFT46_16695	COG0395	ABC-type sugar transport system, permease component
LFT46_16700	COG1175	transmembrane transport
LFT46_16720	COG0395	ABC-type sugar transport system, permease component
LFT46_16725	COG1175	transmembrane transport
LFT46_16755	COG4948	Mandelate Racemase Muconate Lactonizing
LFT46_16760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LFT46_16770	COG0673	inositol 2-dehydrogenase activity
LFT46_16775	COG1609	Transcriptional regulator
LFT46_16785	COG0640	Transcriptional regulator
LFT46_16790	COG0123	including yeast histone deacetylase and acetoin utilization protein
LFT46_16795	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LFT46_16800	COG0569	domain protein
LFT46_16805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LFT46_16810	COG0248	Ppx GppA phosphatase
LFT46_16820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LFT46_16820	COG1754	DNA topoisomerase type I activity
LFT46_16825	COG2890	protein-(glutamine-N5) methyltransferase activity
LFT46_16840	COG1054	Belongs to the UPF0176 family
LFT46_16850	COG1111	helicase
LFT46_16850	COG1205	dead DEAH box helicase
LFT46_16915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LFT46_16930	COG0395	ABC-type sugar transport system, permease component
LFT46_16935	COG1349	DNA-binding transcription factor activity
LFT46_16960	COG0395	ABC-type sugar transport system, permease component
LFT46_16965	COG1653	transport
LFT46_16970	COG1609	Transcriptional regulator
LFT46_16980	COG3833	ABC-type maltose transport systems, permease component
LFT46_16985	COG0395	ABC-type sugar transport system, permease component
LFT46_17020	COG0395	ABC-type sugar transport system, permease component
LFT46_17025	COG1175	transmembrane transport
LFT46_17035	COG1609	Transcriptional regulator
LFT46_17055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LFT46_17060	COG1408	metallophosphoesterase
LFT46_17065	COG1132	(ABC) transporter
LFT46_17070	COG1132	(ABC) transporter
LFT46_17090	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LFT46_17095	COG0151	Belongs to the GarS family
LFT46_17125	COG1953	Uracil, thiamine, allantoin
LFT46_17130	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LFT46_17155	COG0667	Aldo Keto reductase
LFT46_17160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LFT46_17170	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LFT46_17170	COG3608	succinylglutamate desuccinylase aspartoacylase
LFT46_17175	COG2252	PERMEase
LFT46_17180	COG0590	tRNA wobble adenosine to inosine editing
LFT46_17190	COG1793	dna ligase
LFT46_17190	COG3285	dna ligase
LFT46_17205	COG2233	PERMEase
LFT46_17210	COG1414	Transcriptional regulator
LFT46_17220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LFT46_17230	COG3257	ureidoglycine aminohydrolase activity
LFT46_17245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LFT46_17255	COG3387	PFAM Glycoside hydrolase 15-related
LFT46_17280	COG0484	heat shock protein binding
LFT46_17285	COG0071	Belongs to the small heat shock protein (HSP20) family
LFT46_17290	COG0789	Transcriptional regulator
LFT46_17305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LFT46_17310	COG0563	adenylate kinase activity
LFT46_17320	COG0745	RESPONSE REGULATOR receiver
LFT46_17325	COG2267	carboxylic ester hydrolase activity
LFT46_17330	COG0640	Transcriptional regulator
LFT46_17350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT46_17390	COG4499	WXG100 protein secretion system (Wss), protein YukC
LFT46_17390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LFT46_17450	COG2070	2-Nitropropane dioxygenase
LFT46_17455	COG1064	alcohol dehydrogenase
LFT46_17460	COG1063	alcohol dehydrogenase
LFT46_17480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LFT46_17515	COG3739	integral membrane protein
LFT46_17535	COG0129	dihydroxy-acid dehydratase activity
LFT46_17550	COG0726	polysaccharide deacetylase
LFT46_17560	COG2508	Transcriptional regulator
LFT46_17570	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LFT46_17585	COG0477	Major facilitator Superfamily
LFT46_17595	COG1012	belongs to the aldehyde dehydrogenase family
LFT46_17600	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_17610	COG1024	Enoyl-CoA hydratase
LFT46_17625	COG0477	Major facilitator Superfamily
LFT46_17630	COG1396	sequence-specific DNA binding
LFT46_17660	COG2135	peptidase activity
LFT46_17680	COG0640	Transcriptional regulator
LFT46_17700	COG2755	lipolytic protein G-D-S-L family
LFT46_17710	COG2801	Transposase and inactivated derivatives
LFT46_17740	COG0454	-acetyltransferase
LFT46_17765	COG1960	acyl-CoA dehydrogenase activity
LFT46_17770	COG0583	DNA-binding transcription factor activity
LFT46_17775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LFT46_17785	COG1960	acyl-CoA dehydrogenase activity
LFT46_17790	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_17805	COG0477	Major facilitator Superfamily
LFT46_17825	COG2807	transmembrane transport
LFT46_17835	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LFT46_17840	COG4251	negative regulation of phosphorylation
LFT46_17850	COG2329	Antibiotic biosynthesis monooxygenase
LFT46_17860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LFT46_17865	COG2197	response regulator
LFT46_17870	COG3850	Histidine kinase
LFT46_17880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LFT46_17905	COG4585	Histidine kinase
LFT46_17925	COG0726	polysaccharide deacetylase
LFT46_17935	COG3401	FG-GAP repeat protein
LFT46_17945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LFT46_17970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LFT46_18005	COG2801	Transposase and inactivated derivatives
LFT46_18005	COG3415	Transposase
LFT46_18030	COG1473	amidohydrolase
LFT46_18035	COG0477	Major facilitator Superfamily
LFT46_18040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LFT46_18045	COG1609	Transcriptional regulator
LFT46_18055	COG3622	Belongs to the hyi family
LFT46_18060	COG2084	Dehydrogenase
LFT46_18065	COG3960	tartronate-semialdehyde synthase activity
LFT46_18070	COG1929	Belongs to the glycerate kinase type-1 family
LFT46_18075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LFT46_18115	COG1215	transferase activity, transferring glycosyl groups
LFT46_18120	COG1366	Belongs to the anti-sigma-factor antagonist family
LFT46_18135	COG2351	hydroxyisourate hydrolase activity
LFT46_18145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LFT46_18155	COG1802	Transcriptional regulator
LFT46_18175	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LFT46_18185	COG2271	Major facilitator Superfamily
LFT46_18195	COG1063	alcohol dehydrogenase
LFT46_18210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LFT46_18230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LFT46_18325	COG3547	Transposase (IS116 IS110 IS902 family)
LFT46_18330	COG1475	DNA binding
LFT46_18345	COG0346	lactoylglutathione lyase activity
LFT46_18410	COG3585	molybdate ion transport
LFT46_18435	COG0135	phosphoribosylanthranilate isomerase activity
LFT46_18460	COG0667	Aldo Keto reductase
LFT46_18475	COG0701	Predicted permease
LFT46_18485	COG0500	methyltransferase
LFT46_18495	COG2807	transmembrane transport
LFT46_18505	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LFT46_18565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LFT46_18640	COG1760	l-serine dehydratase
LFT46_18665	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LFT46_18695	COG0179	Fumarylacetoacetate (FAA) hydrolase
LFT46_18715	COG3971	2-oxopent-4-enoate hydratase activity
LFT46_18730	COG0789	Transcriptional regulator
LFT46_18735	COG0484	heat shock protein binding
LFT46_18740	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LFT46_18745	COG0443	Heat shock 70 kDa protein
LFT46_18755	COG2409	Drug exporters of the RND superfamily
LFT46_18770	COG1280	lysine exporter protein (LysE YggA)
LFT46_18775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LFT46_18790	COG2814	Major facilitator Superfamily
LFT46_18795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LFT46_18840	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LFT46_18845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LFT46_18855	COG1122	ATPase activity
LFT46_18860	COG4721	ABC-type cobalt transport system, permease component
LFT46_18885	COG1320	monovalent cation:proton antiporter activity
LFT46_18890	COG2212	antiporter activity
LFT46_18900	COG0651	ATP synthesis coupled electron transport
LFT46_18905	COG1006	Multisubunit Na H antiporter MnhC subunit
LFT46_18910	COG2111	Na H antiporter
LFT46_18910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LFT46_18925	COG0475	glutathione-regulated potassium exporter activity
LFT46_18930	COG0717	Belongs to the dCTP deaminase family
LFT46_18960	COG0583	DNA-binding transcription factor activity
LFT46_18970	COG1012	belongs to the aldehyde dehydrogenase family
LFT46_18975	COG0531	amino acid
LFT46_18980	COG0583	DNA-binding transcription factor activity
LFT46_18985	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LFT46_19000	COG2814	Major facilitator Superfamily
LFT46_19005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT46_19010	COG0667	Aldo Keto reductase
LFT46_19025	COG0395	ABC-type sugar transport system, permease component
LFT46_19030	COG1175	transmembrane transport
LFT46_19040	COG1609	Transcriptional regulator
LFT46_19050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LFT46_19060	COG2814	Major facilitator Superfamily
LFT46_19065	COG0583	DNA-binding transcription factor activity
LFT46_19095	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LFT46_19100	COG4638	Rieske (2fe-2S)
LFT46_19105	COG3485	protocatechuate 3,4-dioxygenase
LFT46_19120	COG1012	belongs to the aldehyde dehydrogenase family
LFT46_19135	COG2826	transposase and inactivated derivatives, IS30 family
LFT46_19145	COG3845	ABC transporter
LFT46_19150	COG0488	(ABC) transporter
LFT46_19155	COG1410	methionine synthase
LFT46_19155	COG0646	methionine synthase
LFT46_19160	COG4974	Belongs to the 'phage' integrase family
LFT46_19205	COG4974	Belongs to the 'phage' integrase family
LFT46_19260	COG4638	Rieske (2fe-2S)
LFT46_19265	COG0656	L-ascorbic acid biosynthetic process
LFT46_19275	COG1335	isochorismatase
LFT46_19285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LFT46_19320	COG1414	Transcriptional regulator
LFT46_19355	COG1129	ABC transporter
LFT46_19360	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT46_19400	COG2267	carboxylic ester hydrolase activity
LFT46_19405	COG1609	Transcriptional regulator
LFT46_19410	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_19415	COG3246	L-lysine catabolic process to acetate
LFT46_19425	COG3415	Transposase
LFT46_19425	COG2801	Transposase and inactivated derivatives
LFT46_19445	COG1609	Transcriptional regulator
LFT46_19455	COG1175	transmembrane transport
LFT46_19460	COG0395	ABC-type sugar transport system, permease component
LFT46_19465	COG1621	beta-fructofuranosidase activity
LFT46_19480	COG0583	DNA-binding transcription factor activity
LFT46_19485	COG2828	Protein conserved in bacteria
LFT46_19490	COG1301	dicarboxylic acid transport
LFT46_19510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT46_19525	COG1126	abc transporter atp-binding protein
LFT46_19530	COG0765	amino acid transport
LFT46_19545	COG0433	COG0433 Predicted ATPase
LFT46_19565	COG3336	cytochrome c oxidase
LFT46_19570	COG0776	regulation of translation
LFT46_19595	COG1609	Transcriptional regulator
LFT46_19615	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LFT46_19620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LFT46_19625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LFT46_19630	COG1017	nitric oxide dioxygenase activity
LFT46_19630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LFT46_19670	COG1120	ATPase activity
LFT46_19675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LFT46_19680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LFT46_19730	COG3012	SEC-C Motif Domain Protein
LFT46_19740	COG0667	Aldo Keto reductase
LFT46_19780	COG0586	Pfam SNARE associated Golgi protein
LFT46_19795	COG1027	Aspartate ammonia-lyase
LFT46_19805	COG0405	Gamma-glutamyltransferase
LFT46_19810	COG0039	L-malate dehydrogenase activity
LFT46_19815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LFT46_19825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LFT46_19835	COG1522	sequence-specific DNA binding
LFT46_19840	COG1280	lysine exporter protein (LysE YggA)
LFT46_19865	COG0281	malic enzyme
LFT46_19870	COG1309	transcriptional regulator
LFT46_19885	COG0477	Major facilitator Superfamily
LFT46_19890	COG0477	Major facilitator Superfamily
LFT46_19895	COG2814	Major facilitator Superfamily
LFT46_19910	COG2826	transposase and inactivated derivatives, IS30 family
LFT46_19915	COG0246	Mannitol dehydrogenase
LFT46_19920	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LFT46_19920	COG2213	PTS system mannitol-specific
LFT46_19930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LFT46_19940	COG2267	carboxylic ester hydrolase activity
LFT46_19950	COG0686	Belongs to the AlaDH PNT family
LFT46_19955	COG0673	inositol 2-dehydrogenase activity
LFT46_19995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LFT46_20000	COG0589	response to stress
LFT46_20015	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT46_20020	COG0022	dehydrogenase e1 component
LFT46_20030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LFT46_20055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LFT46_20060	COG0406	alpha-ribazole phosphatase activity
LFT46_20080	COG1840	ABC-type Fe3 transport system, periplasmic component
LFT46_20085	COG3842	ATPase activity
LFT46_20090	COG1178	ABC-type Fe3 transport system permease component
LFT46_20110	COG1414	Transcriptional regulator
LFT46_20115	COG2814	Major facilitator Superfamily
LFT46_20135	COG2271	Major facilitator Superfamily
LFT46_20140	COG1802	Transcriptional regulator
LFT46_20160	COG1597	lipid kinase activity
LFT46_20190	COG1414	Transcriptional regulator
LFT46_20195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LFT46_20200	COG0477	Major facilitator Superfamily
LFT46_20210	COG1414	Transcriptional regulator
LFT46_20215	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LFT46_20225	COG0183	Belongs to the thiolase family
LFT46_20230	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LFT46_20240	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LFT46_20245	COG3485	protocatechuate 3,4-dioxygenase
LFT46_20250	COG3485	protocatechuate 3,4-dioxygenase
LFT46_20255	COG1082	Xylose isomerase domain protein TIM barrel
LFT46_20255	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LFT46_20260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LFT46_20265	COG1414	Transcriptional regulator
LFT46_20270	COG0477	Major facilitator Superfamily
LFT46_20275	COG1793	dna ligase
LFT46_20310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LFT46_20320	COG1012	belongs to the aldehyde dehydrogenase family
LFT46_20325	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LFT46_20335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LFT46_20370	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LFT46_20400	COG1937	Protein conserved in bacteria
LFT46_20425	COG0697	spore germination
LFT46_20450	COG2259	Doxx family
LFT46_20460	COG0305	Participates in initiation and elongation during chromosome replication
LFT46_20475	COG0384	phenazine biosynthesis protein PhzF
LFT46_20480	COG0359	binds to the 23S rRNA
LFT46_20485	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LFT46_20495	COG0360	Binds together with S18 to 16S ribosomal RNA
LFT46_20505	COG0489	protein tyrosine kinase activity
LFT46_20550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LFT46_20560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LFT46_20570	COG1362	aminopeptidase activity
LFT46_20575	COG1113	amino acid transport
LFT46_20595	COG0738	Major facilitator superfamily
LFT46_20605	COG0488	(ABC) transporter
LFT46_20610	COG0768	penicillin binding
LFT46_20625	COG0406	alpha-ribazole phosphatase activity
LFT46_20630	COG0617	tRNA 3'-terminal CCA addition
LFT46_20650	COG0492	ferredoxin-NADP+ reductase activity
LFT46_20655	COG3118	belongs to the thioredoxin family
LFT46_20665	COG1192	Involved in chromosome partitioning
LFT46_20670	COG0357	Ribosomal RNA small subunit methyltransferase G
LFT46_20680	COG0706	membrane insertase activity
LFT46_20685	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LFT46_20690	COG0594	ribonuclease P activity
LFT46_20695	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LFT46_20705	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LFT46_20710	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT46_20715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LFT46_20720	COG2390	Transcriptional regulator
LFT46_20725	COG1879	ABC-type sugar transport system periplasmic component
LFT46_20730	COG1129	ABC transporter
LFT46_20735	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT46_20740	COG1070	Carbohydrate kinase
LFT46_20745	COG1028	Short-chain dehydrogenase reductase Sdr
LFT46_20765	COG2826	transposase and inactivated derivatives, IS30 family
LFT46_20785	COG1129	ABC transporter
LFT46_20790	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT46_20800	COG2376	Dihydroxyacetone kinase
LFT46_20805	COG0698	ribose 5-phosphate isomerase
LFT46_20810	COG0149	triose-phosphate isomerase activity
LFT46_20815	COG1349	DNA-binding transcription factor activity
LFT46_20820	COG1063	alcohol dehydrogenase
LFT46_20835	COG4974	Belongs to the 'phage' integrase family
LFT46_20895	COG1475	DNA binding
LFT46_20900	COG3547	Transposase (IS116 IS110 IS902 family)
LFT46_20990	COG0489	protein tyrosine kinase activity
LFT46_21060	COG0515	serine threonine protein kinase
LFT46_21060	COG2815	serine threonine protein kinase
LFT46_21085	COG1063	alcohol dehydrogenase
LFT46_21090	COG0395	ABC-type sugar transport system, permease component
LFT46_21110	COG1070	Carbohydrate kinase
LFT46_21125	COG0596	Alpha beta hydrolase
LFT46_21135	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT46_21145	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LFT46_21150	COG0191	fructose-bisphosphate aldolase activity