locus-tag	class	description
AHiyo4_00010	ENOG4106WTF	Glycosyl transferase, family 2
AHiyo4_00020	ENOG4105DFM	M18 family aminopeptidase
AHiyo4_00030	ENOG4105DFM	M18 family aminopeptidase
AHiyo4_00050	ENOG4105WH1	Two component transcriptional regulator luxr family
AHiyo4_00110	ENOG4106UW1	Major Facilitator superfamily
AHiyo4_00120	ENOG4106UW1	Major Facilitator superfamily
AHiyo4_00140	ENOG4105C5H	ABC transporter
AHiyo4_00180	ENOG4107S11	squalene-associated FAD-dependent desaturase
AHiyo4_00220	ENOG4108ZM9	phosphoglycerate mutase
AHiyo4_00240	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
AHiyo4_00300	ENOG4105C3M	thioredoxin reductase
AHiyo4_00310	ENOG4105K63	Thioredoxin
AHiyo4_00350	ENOG4107QJE	Chromosome Partitioning Protein
AHiyo4_00370	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
AHiyo4_00400	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
AHiyo4_00410	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
AHiyo4_00430	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
AHiyo4_00440	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
AHiyo4_00450	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
AHiyo4_00460	ENOG4108J5G	6-phosphogluconate dehydrogenase
AHiyo4_00470	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
AHiyo4_00480	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
AHiyo4_00490	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
AHiyo4_00500	ENOG4105K7N	UPF0232 protein
AHiyo4_00510	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AHiyo4_00520	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AHiyo4_00530	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AHiyo4_00540	ENOG4108ZED	Transmembrane domain of unknown function (DUF3566)
AHiyo4_00580	ENOG4107R8N	Glycosyl transferase, family 2
AHiyo4_00630	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
AHiyo4_00640	ENOG4108R3E	Dna-3-methyladenine glycosylase i
AHiyo4_00650	ENOG4105ZJT	Cell division protein CrgA
AHiyo4_00660	ENOG4108U4N	(sortase) family
AHiyo4_00710	ENOG4107TPY	serine threonine protein kinase
AHiyo4_00730	ENOG4105CJN	penicillin-binding protein
AHiyo4_00750	ENOG4107QHZ	cell cycle protein
AHiyo4_00770	ENOG4105HZM	Fha domain containing protein
AHiyo4_00780	ENOG4105TV9	FHA Domain-Containing protein
AHiyo4_00910	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
AHiyo4_00990	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
AHiyo4_01030	ENOG4105F38	ABC transporter, permease
AHiyo4_01050	ENOG4105F38	ABC transporter, permease
AHiyo4_01060	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
AHiyo4_01070	ENOG4105C26	Dehydrogenase
AHiyo4_01080	ENOG4105C26	Dehydrogenase
AHiyo4_01110	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
AHiyo4_01130	ENOG4105C26	Dehydrogenase
AHiyo4_01140	ENOG4105C26	Dehydrogenase
AHiyo4_01160	ENOG4105CJP	fad dependent oxidoreductase
AHiyo4_01240	ENOG41073TP	transcriptional regulator
AHiyo4_01250	ENOG4105E7W	lamb ycsf family protein
AHiyo4_01260	ENOG4105CSH	Transporter
AHiyo4_01270	ENOG4105P4J	Allophanate hydrolase, subunit 1
AHiyo4_01290	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
AHiyo4_01300	ENOG4108JIK	carboxylase
AHiyo4_01330	ENOG4108YZ9	Urea amidohydrolase subunit gamma
AHiyo4_01340	ENOG4105KI2	Urea amidohydrolase subunit beta
AHiyo4_01360	ENOG4105CQM	Urea amidohydrolase subunit alpha
AHiyo4_01370	ENOG4105HFU	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
AHiyo4_01380	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
AHiyo4_01400	ENOG4107S16	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
AHiyo4_01410	ENOG4105ICD	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
AHiyo4_01420	ENOG4105ICD	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
AHiyo4_01430	ENOG4105D9G	High-affinity
AHiyo4_01450	ENOG4105C2C	drug resistance transporter, Bcr CflA
AHiyo4_01460	ENOG4105VG9	Plasmid stabilization system
AHiyo4_01470	ENOG41067D0	Antitoxin component of a toxin-antitoxin (TA) module. Upon expression in M.smegmatis neutralizes the effect of toxin RelE2
AHiyo4_01500	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
AHiyo4_01530	ENOG4105WH1	Two component transcriptional regulator luxr family
AHiyo4_01540	ENOG4105BZU	Histidine kinase
AHiyo4_01550	ENOG4105CHH	sulfate transporter
AHiyo4_01560	ENOG41090CE	integral membrane protein
AHiyo4_01630	ENOG4105ETE	Transcriptional regulator (LacI family
AHiyo4_01670	ENOG4105BZU	Histidine kinase
AHiyo4_01750	ENOG4107RB3	L-asparaginase
AHiyo4_01770	ENOG410819M	Polysaccharide deacetylase
AHiyo4_01780	ENOG410819M	Polysaccharide deacetylase
AHiyo4_01790	ENOG4105ETE	Transcriptional regulator (LacI family
AHiyo4_01800	ENOG4105ETE	Transcriptional regulator (LacI family
AHiyo4_01820	ENOG4105CKI	cobalamin synthesis protein
AHiyo4_01840	ENOG4105C1G	acyl-Coa dehydrogenase
AHiyo4_01890	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
AHiyo4_01940	ENOG4107RSM	transcriptional regulator
AHiyo4_01970	ENOG4105EUJ	GTP cyclohydrolase i
AHiyo4_01980	ENOG4105EUJ	GTP cyclohydrolase i
AHiyo4_02020	ENOG4105DAE	Methylenetetrahydrofolate reductase
AHiyo4_02040	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
AHiyo4_02050	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
AHiyo4_02140	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
AHiyo4_02150	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
AHiyo4_02200	ENOG4105EJQ	L-serine dehydratase
AHiyo4_02210	ENOG4105EJQ	L-serine dehydratase
AHiyo4_02340	ENOG4105C85	amino acid
AHiyo4_02350	ENOG4105C85	amino acid
AHiyo4_02400	ENOG41089UC	methyltransferase, type 11
AHiyo4_02420	ENOG41082SX	arsR family transcriptional regulator
AHiyo4_02430	ENOG4105DXI	Major Facilitator superfamily
AHiyo4_02440	ENOG4105DXI	Major Facilitator superfamily
AHiyo4_02450	ENOG41082SX	arsR family transcriptional regulator
AHiyo4_02500	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
AHiyo4_02510	ENOG4105BZU	Histidine kinase
AHiyo4_02520	ENOG4105BZU	Histidine kinase
AHiyo4_02530	ENOG4105BZU	Histidine kinase
AHiyo4_02540	ENOG4105BZU	Histidine kinase
AHiyo4_02580	ENOG4105BZW	Glycerate kinase
AHiyo4_02640	ENOG41090WU	lipolytic protein G-D-S-L family
AHiyo4_02650	ENOG4105C2W	permease
AHiyo4_02660	ENOG4105C2W	permease
AHiyo4_02670	ENOG4108RDT	NADH dehydrogenase NAD(P)H nitroreductase)
AHiyo4_02680	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
AHiyo4_02770	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
AHiyo4_02780	ENOG4105VFE	sira family
AHiyo4_02810	ENOG4107TE5	Lipid kinase
AHiyo4_02820	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
AHiyo4_02840	ENOG410667J	hydrolase
AHiyo4_02850	ENOG4108KP7	hydrolase
AHiyo4_02880	ENOG4107QRI	Phosphoketolase
AHiyo4_02910	ENOG4105EBR	Carboxylesterase
AHiyo4_02980	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
AHiyo4_03010	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
AHiyo4_03020	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
AHiyo4_03030	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
AHiyo4_03040	ENOG4105EUJ	GTP cyclohydrolase i
AHiyo4_03050	ENOG4105EEI	dihydropteroate synthase
AHiyo4_03080	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AHiyo4_03120	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
AHiyo4_03130	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
AHiyo4_03210	ENOG4108JGH	Tetr family transcriptional regulator
AHiyo4_03300	ENOG4105CRK	lysyL-tRNA synthetase
AHiyo4_03330	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
AHiyo4_03360	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
AHiyo4_03380	ENOG4105CMT	Dihydroxyacetone kinase
AHiyo4_03390	ENOG4105CMT	Dihydroxyacetone kinase
AHiyo4_03400	ENOG4108UTZ	Dihydroxyacetone kinase
AHiyo4_03430	ENOG4105VDH	Dihydroxyacetone kinase
AHiyo4_03500	ENOG4105E59	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity)
AHiyo4_03510	ENOG4105E59	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity)
AHiyo4_03520	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
AHiyo4_03580	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
AHiyo4_03590	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
AHiyo4_03620	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
AHiyo4_03630	ENOG4107QXV	Phosphate transporter
AHiyo4_03790	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
AHiyo4_03850	ENOG4105Y3U	Transglycosylase-associated protein
AHiyo4_03860	ENOG4105CV8	reductase
AHiyo4_03870	ENOG4105CV8	reductase
AHiyo4_03900	ENOG4105CPC	Aldo Keto reductase
AHiyo4_03910	ENOG4105CPC	Aldo Keto reductase
AHiyo4_03920	ENOG4105CV8	reductase
AHiyo4_03930	ENOG4105WKW	Pfam:DUF1458
AHiyo4_03940	ENOG4107EJG	GntR family transcriptional regulator
AHiyo4_03950	ENOG4105ZXK	Dehydrogenase
AHiyo4_03990	ENOG4105DY8	decarboxylase
AHiyo4_04000	ENOG4105F1Y	L-lysine 6-monooxygenase (NADPH)
AHiyo4_04030	ENOG4105DUU	IucA IucC family protein
AHiyo4_04080	ENOG4108W6C	Dehydrogenase
AHiyo4_04110	ENOG4105CSH	Transporter
AHiyo4_04150	ENOG4105FDF	Could be involved in DNA repair (By similarity)
AHiyo4_04220	ENOG4105DM4	PTS System
AHiyo4_04230	ENOG4105DM4	PTS System
AHiyo4_04240	ENOG4105DE4	1-phosphofructokinase
AHiyo4_04250	ENOG4105E98	transcriptional regulator DeoR family
AHiyo4_04330	ENOG4105E7W	lamb ycsf family protein
AHiyo4_04340	ENOG4105E7W	lamb ycsf family protein
AHiyo4_04350	ENOG4106BRA	Membrane
AHiyo4_04570	ENOG4105KVH	Transcriptional regulator
AHiyo4_04590	ENOG4105ECR	NmrA family
AHiyo4_04600	ENOG4105N14	lysine exporter protein LysE YggA
AHiyo4_04610	ENOG4105C85	amino acid
AHiyo4_04620	ENOG4105C85	amino acid
AHiyo4_04630	ENOG4105VZ8	Transcriptional regulator
AHiyo4_04710	ENOG4105CGP	Urocanate hydratase
AHiyo4_04720	ENOG4105CGP	Urocanate hydratase
AHiyo4_04730	ENOG4105C84	Histidine ammonia-lyase
AHiyo4_04740	ENOG4105C84	Histidine ammonia-lyase
AHiyo4_04750	ENOG4105C84	Histidine ammonia-lyase
AHiyo4_04780	ENOG4105SHT	UspA domain-containing protein
AHiyo4_04850	ENOG4108MRH	transcriptional regulatory protein
AHiyo4_04860	ENOG4105C7N	Xanthine uracil vitamin C permease
AHiyo4_04870	ENOG4105C7N	Xanthine uracil vitamin C permease
AHiyo4_04890	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
AHiyo4_04900	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
AHiyo4_04940	ENOG4107R95	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
AHiyo4_04950	ENOG4107R95	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
AHiyo4_04960	ENOG4107R95	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
AHiyo4_05020	ENOG4105ZXU	NLP P60 protein
AHiyo4_05090	ENOG4105DCG	PHP domain protein
AHiyo4_05110	ENOG4108HKT	sucrose-6-phosphate hydrolase
AHiyo4_05190	ENOG4105EPJ	extracellular solute-binding protein family 1
AHiyo4_05200	ENOG4105EPJ	extracellular solute-binding protein family 1
AHiyo4_05210	ENOG4105S9S	Binding-protein-dependent transport systems, inner membrane component
AHiyo4_05220	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
AHiyo4_05230	ENOG4105ETE	Transcriptional regulator (LacI family
AHiyo4_05270	ENOG4105C26	Dehydrogenase
AHiyo4_05310	ENOG4105E39	Enoyl-CoA hydratase
AHiyo4_05330	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
AHiyo4_05340	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
AHiyo4_05350	ENOG4105C1G	acyl-Coa dehydrogenase
AHiyo4_05360	ENOG4105VEQ	Cold shock protein
AHiyo4_05370	ENOG4105WH1	Two component transcriptional regulator luxr family
AHiyo4_05400	ENOG4107SNB	ankyrin repeat protein YahD
AHiyo4_05410	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
AHiyo4_05490	ENOG4105D6N	CoA-transferase, subunit a
AHiyo4_05530	ENOG4105ETE	Transcriptional regulator (LacI family
AHiyo4_05630	ENOG4108JQ7	(ABC) transporter
AHiyo4_05660	ENOG4105CK5	oxidoreductase
AHiyo4_05680	ENOG4105ETE	Transcriptional regulator (LacI family
AHiyo4_05690	ENOG4105D2H	Uronic isomerase
AHiyo4_05700	ENOG4105DEI	Mannitol dehydrogenase
AHiyo4_05710	ENOG4105CT4	transporter
AHiyo4_05720	ENOG4105CXK	mandelate racemase muconate lactonizing
AHiyo4_05730	ENOG4105D17	glycoside hydrolase, family 3 domain protein
AHiyo4_05750	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
AHiyo4_05840	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
AHiyo4_05850	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
AHiyo4_05880	ENOG4105K4P	CoA-binding domain protein
AHiyo4_05920	ENOG4105MSB	protein, conserved in bacteria
AHiyo4_05960	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
AHiyo4_05970	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
AHiyo4_05980	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
AHiyo4_06090	ENOG4105K56	Transcriptional regulator
AHiyo4_06120	ENOG4105CFH	Aspartokinase
AHiyo4_06130	ENOG4105CJ1	ABC, transporter
AHiyo4_06160	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
AHiyo4_06200	ENOG4105EGD	dinuclear metal center protein, YbgI family
AHiyo4_06240	ENOG4105E4C	Lytic transglycosylase catalytic
AHiyo4_06250	ENOG4108V06	Glutathione peroxidase
AHiyo4_06270	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
AHiyo4_06340	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
AHiyo4_06410	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
AHiyo4_06460	ENOG4105DJ2	Major Facilitator Superfamily
AHiyo4_06480	ENOG4107R9S	Malate synthase
AHiyo4_06500	ENOG4107R9S	Malate synthase
AHiyo4_06560	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
AHiyo4_06570	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
AHiyo4_06660	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
AHiyo4_06720	ENOG4105C1G	acyl-Coa dehydrogenase
AHiyo4_06750	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
AHiyo4_06760	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
AHiyo4_06770	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
AHiyo4_06860	ENOG4108UVJ	appr-1-p processing domain protein
AHiyo4_06870	ENOG4108W1A	pseudouridine synthase
AHiyo4_06900	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
AHiyo4_06920	ENOG4108VW9	Membrane
AHiyo4_06960	ENOG4107QRT	dEAD DEAH box helicase
AHiyo4_06970	ENOG4107QRT	dEAD DEAH box helicase
AHiyo4_07020	ENOG41060NJ	transcriptional regulator
AHiyo4_07040	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
AHiyo4_07050	ENOG4105E0S	extracellular solute-binding protein family 1
AHiyo4_07070	ENOG4108HKT	sucrose-6-phosphate hydrolase
AHiyo4_07140	ENOG4105EA8	2-Nitropropane dioxygenase
AHiyo4_07240	ENOG4108Z6B	deaminase
AHiyo4_07250	ENOG410841Q	phosphoesterase PA-phosphatase related protein
AHiyo4_07260	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
AHiyo4_07300	ENOG4105BZU	Histidine kinase
AHiyo4_07310	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AHiyo4_07350	ENOG4108594	Permease of the drug metabolite transporter
AHiyo4_07370	ENOG4108IG5	Transcriptional regulator
AHiyo4_07380	ENOG4105ECB	domain protein
AHiyo4_07420	ENOG4107QN2	dihydrolipoyl dehydrogenase
AHiyo4_07440	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
AHiyo4_07450	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
AHiyo4_07460	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
AHiyo4_07490	ENOG4107QKV	phosphomannomutase
AHiyo4_07510	ENOG4107QKV	phosphomannomutase
AHiyo4_07520	ENOG4105C9U	ATP-dependent DNA helicase RecQ
AHiyo4_07530	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
AHiyo4_07550	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
AHiyo4_07580	ENOG4108IE3	prolyl oligopeptidase
AHiyo4_07620	ENOG4108KU3	Integrase
AHiyo4_07770	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
AHiyo4_07790	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
AHiyo4_07810	ENOG4105D22	carbon starvation protein
AHiyo4_07850	ENOG4108VC7	Protein of unknown function (DUF2587)
AHiyo4_07940	ENOG4105C6E	dna polymerase iii
AHiyo4_07950	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
AHiyo4_07960	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
AHiyo4_08010	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
AHiyo4_08030	ENOG4105BZU	Histidine kinase
AHiyo4_08080	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
AHiyo4_08090	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
AHiyo4_08110	ENOG4105C8N	cysteinyl-tRNA synthetase
AHiyo4_08210	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
AHiyo4_08230	ENOG4105CG3	alpha amylase, catalytic region
AHiyo4_08260	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
AHiyo4_08270	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
AHiyo4_08280	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
AHiyo4_08300	ENOG4105ETE	Transcriptional regulator (LacI family
AHiyo4_08310	ENOG4105CG3	alpha amylase, catalytic region
AHiyo4_08340	ENOG4105CQB	FAD linked oxidase domain protein
AHiyo4_08350	ENOG4105CQB	FAD linked oxidase domain protein
AHiyo4_08370	ENOG4108IJ9	(ABC) transporter
AHiyo4_08390	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
AHiyo4_08460	ENOG4105D5Q	Arginine ornithine antiporter
AHiyo4_08470	ENOG4105DWY	Agmatine deiminase
AHiyo4_08480	ENOG4107QPI	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
AHiyo4_08490	ENOG4105DPV	During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction
AHiyo4_08500	ENOG4105C57	major facilitator superfamily
AHiyo4_08520	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_08530	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_08610	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
AHiyo4_08650	ENOG4105VEQ	Cold shock protein
AHiyo4_08670	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
AHiyo4_08710	ENOG4105BZU	Histidine kinase
AHiyo4_08730	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AHiyo4_08790	ENOG4105VEQ	Cold shock protein
AHiyo4_08840	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
AHiyo4_08870	ENOG4105DR5	peptidase
AHiyo4_08960	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
AHiyo4_08970	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
AHiyo4_09040	ENOG4105C5H	ABC transporter
AHiyo4_09050	ENOG4105BZ1	(ABC) transporter
AHiyo4_09060	ENOG4105BZ1	(ABC) transporter
AHiyo4_09070	ENOG4105BZ1	(ABC) transporter
AHiyo4_09080	ENOG4108XXK	NUDIX hydrolase
AHiyo4_09150	ENOG4105ECY	inositol monophosphatase
AHiyo4_09220	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
AHiyo4_09250	ENOG4105CV8	reductase
AHiyo4_09270	ENOG4105NPE	arsR family transcriptional regulator
AHiyo4_09280	ENOG41090U3	tautomerase
AHiyo4_09290	ENOG4105D7K	pfkb domain protein
AHiyo4_09320	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
AHiyo4_09340	ENOG4105C26	Dehydrogenase
AHiyo4_09350	ENOG4105C26	Dehydrogenase
AHiyo4_09360	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
AHiyo4_09370	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
AHiyo4_09380	ENOG4105F0H	myo-inositol catabolism protein
AHiyo4_09420	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
AHiyo4_09430	ENOG4105ETE	Transcriptional regulator (LacI family
AHiyo4_09460	ENOG41062B0	ABC transporter, permease
AHiyo4_09470	ENOG4105C2J	ABC transporter
AHiyo4_09480	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
AHiyo4_09490	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
AHiyo4_09500	ENOG4105CK5	oxidoreductase
AHiyo4_09520	ENOG4105CK5	oxidoreductase
AHiyo4_09530	ENOG4107TTA	Xylose isomerase domain protein TIM barrel
AHiyo4_09540	ENOG4105CK5	oxidoreductase
AHiyo4_09550	ENOG41060NJ	transcriptional regulator
AHiyo4_09570	ENOG4105DH8	myo-inositol catabolism
AHiyo4_09590	ENOG41073TP	transcriptional regulator
AHiyo4_09600	ENOG4107QNK	)-transporter
AHiyo4_09680	ENOG4108JCI	Transcriptional regulator
AHiyo4_09730	ENOG4105C7K	acetolactate synthase
AHiyo4_09860	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
AHiyo4_09870	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
AHiyo4_09910	ENOG4105BZU	Histidine kinase
AHiyo4_09920	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AHiyo4_09980	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
AHiyo4_10000	ENOG4105BZM	domain protein
AHiyo4_10020	ENOG4108535	NAD dependent epimerase/dehydratase family
AHiyo4_10060	ENOG4105MS9	Resuscitation-promoting factor
AHiyo4_10070	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
AHiyo4_10080	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
AHiyo4_10120	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
AHiyo4_10180	ENOG41086YM	Acylphosphatase
AHiyo4_10190	ENOG4105F27	Major Facilitator
AHiyo4_10370	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
AHiyo4_10390	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
AHiyo4_10470	ENOG4105VG5	Membrane
AHiyo4_10500	ENOG4105E5M	Multidrug resistance protein D
AHiyo4_10540	ENOG41080RH	Thioredoxin
AHiyo4_10600	ENOG4105XTG	Pfam:DUF156
AHiyo4_10630	ENOG4106PVI	ATP-dependent carboxylate-amine ligase (By similarity)
AHiyo4_10720	ENOG4105E2A	Dehydrogenase
AHiyo4_10780	ENOG4107TPY	serine threonine protein kinase
AHiyo4_10790	ENOG4105D9P	serine threonine protein kinase
AHiyo4_10820	ENOG41085GJ	domain protein
AHiyo4_10860	ENOG4105BZU	Histidine kinase
AHiyo4_10960	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
AHiyo4_10970	ENOG4105C09	Bile acid
AHiyo4_10980	ENOG4105BZG	amino acid carrier protein
AHiyo4_10990	ENOG4105BZG	amino acid carrier protein
AHiyo4_11010	ENOG4105DEI	Mannitol dehydrogenase
AHiyo4_11020	ENOG4105DEI	Mannitol dehydrogenase
AHiyo4_11030	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
AHiyo4_11050	ENOG4105NPE	arsR family transcriptional regulator
AHiyo4_11240	ENOG4105CSH	Transporter
AHiyo4_11260	ENOG41060NJ	transcriptional regulator
AHiyo4_11270	ENOG4105CPC	Aldo Keto reductase
AHiyo4_11320	ENOG4105CIH	Imidazole acetol-phosphate transaminase
AHiyo4_11330	ENOG4105C85	amino acid
AHiyo4_11340	ENOG4108IQI	permease
AHiyo4_11470	ENOG4107W6X	Transcriptional regulator
AHiyo4_11550	ENOG4105F95	Monooxygenase
AHiyo4_11570	ENOG4105CPQ	Dehydrogenase
AHiyo4_11580	ENOG4105KWG	Pfam:DUF1696
AHiyo4_11630	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
AHiyo4_11650	ENOG4105MC2	DSBA oxidoreductase
AHiyo4_11690	ENOG4105ETE	Transcriptional regulator (LacI family
AHiyo4_11700	ENOG4105ETE	Transcriptional regulator (LacI family
AHiyo4_11750	ENOG4105C2J	ABC transporter
AHiyo4_11760	ENOG4105CNN	ABC, transporter
AHiyo4_11770	ENOG4105CNN	ABC, transporter
AHiyo4_11820	ENOG4105NFY	transcriptional modulator of maze toxin, mazf
AHiyo4_11830	ENOG4108Z6B	deaminase
AHiyo4_11870	ENOG4105BZG	amino acid carrier protein
AHiyo4_11890	ENOG4108RVA	ribokinase
AHiyo4_11940	ENOG4105C6F	GntR Family Transcriptional Regulator
AHiyo4_11990	ENOG4105DGI	Alkaline phosphatase
AHiyo4_12020	ENOG4105BZU	Histidine kinase
AHiyo4_12070	ENOG4105E7D	Protein of unknown function (DUF3375)
AHiyo4_12110	ENOG4105VEQ	Cold shock protein
AHiyo4_12140	ENOG4105BZ9	Cytochrome C oxidase, subunit I
AHiyo4_12150	ENOG4105BZ9	Cytochrome C oxidase, subunit I
AHiyo4_12180	ENOG4105C6Z	Gluconate
AHiyo4_12190	ENOG4105C6Z	Gluconate
AHiyo4_12270	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
AHiyo4_12350	ENOG4105BZU	Histidine kinase
AHiyo4_12360	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AHiyo4_12370	ENOG4108UXN	response regulator
AHiyo4_12380	ENOG4105BZU	Histidine kinase
AHiyo4_12390	ENOG4105BZU	Histidine kinase
AHiyo4_12420	ENOG4107TPS	domain protein
AHiyo4_12430	ENOG4108NJZ	Sensory box GGDEF EAL domain protein
AHiyo4_12440	ENOG4105BZU	Histidine kinase
AHiyo4_12450	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
AHiyo4_12460	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
AHiyo4_12510	ENOG4108Z4U	Ferredoxin
AHiyo4_12600	ENOG41079KZ	Major Facilitator Superfamily
AHiyo4_12610	ENOG4105DC1	bifunctional purine biosynthesis protein purh
AHiyo4_12620	ENOG4105DC1	bifunctional purine biosynthesis protein purh
AHiyo4_12700	ENOG4108UGD	Serine Threonine protein kinase
AHiyo4_12740	ENOG4107TYG	Oxidoreductase domain-containing protein
AHiyo4_12750	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
AHiyo4_12790	ENOG4105DFW	ABC transporter
AHiyo4_12800	ENOG4105DFW	ABC transporter
AHiyo4_12820	ENOG41062B0	ABC transporter, permease
AHiyo4_12830	ENOG4105C2J	ABC transporter
AHiyo4_12900	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
AHiyo4_12910	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
AHiyo4_12920	ENOG4105CUB	amino acid
AHiyo4_12950	ENOG4108Z0R	Transferase
AHiyo4_13000	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
AHiyo4_13050	ENOG4105C31	Tryptophanyl-tRNA synthetase
AHiyo4_13060	ENOG4105C31	Tryptophanyl-tRNA synthetase
AHiyo4_13120	ENOG4105E33	succinate dehydrogenase
AHiyo4_13170	ENOG4107RM1	amidohydrolase
AHiyo4_13180	ENOG4105K56	Transcriptional regulator
AHiyo4_13190	ENOG4108ZHJ	Organic hydroperoxide resistance protein
AHiyo4_13200	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
AHiyo4_13210	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
AHiyo4_13240	ENOG4108JQ9	ABC transporter
AHiyo4_13250	ENOG4108JQ9	ABC transporter
AHiyo4_13260	ENOG4105UIB	(ABC) transporter
AHiyo4_13270	ENOG41080EB	ABC transporter, permease
AHiyo4_13330	ENOG4107XFB	conserved TRANSMEMBRANE PROTEIN
AHiyo4_13340	ENOG4107XFB	conserved TRANSMEMBRANE PROTEIN
AHiyo4_13360	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
AHiyo4_13370	ENOG4105DXN	mazG family
AHiyo4_13380	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
AHiyo4_13390	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
AHiyo4_13510	ENOG4108IV0	ABC, transporter
AHiyo4_13520	ENOG4108IV0	ABC, transporter
AHiyo4_13530	ENOG4105C0Z	ABC transporter
AHiyo4_13540	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
AHiyo4_13550	ENOG4105C32	Amino acid ABC transporter (Permease)
AHiyo4_13570	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
AHiyo4_13580	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
AHiyo4_13640	ENOG4105C7B	Threonine dehydratase
AHiyo4_13650	ENOG4105NDT	Rhomboid family
AHiyo4_13660	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
AHiyo4_13680	ENOG4105T1M	mycothiol conjugate amidase mca
AHiyo4_13710	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
AHiyo4_13720	ENOG4108IAB	Phoh family
AHiyo4_13730	ENOG4108IAB	Phoh family
AHiyo4_13790	ENOG4105C9Q	fumarate hydratase class II
AHiyo4_13800	ENOG4108V9Q	carbonic anhydrase
AHiyo4_13850	ENOG4105EIP	mannose-6-phosphate isomerase
AHiyo4_13870	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
AHiyo4_13880	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
AHiyo4_13910	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
AHiyo4_13920	ENOG4107RGC	Glycosyl transferase, family 2
AHiyo4_14020	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
AHiyo4_14170	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
AHiyo4_14180	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
AHiyo4_14200	ENOG4105F8V	Hydrolase, tatD family
AHiyo4_14210	ENOG41069ER	domain protein
AHiyo4_14230	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
AHiyo4_14240	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
AHiyo4_14250	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
AHiyo4_14260	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
AHiyo4_14270	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
AHiyo4_14280	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
AHiyo4_14290	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
AHiyo4_14300	ENOG4105C5H	ABC transporter
AHiyo4_14330	ENOG41067SE	Tetr family transcriptional regulator
AHiyo4_14340	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
AHiyo4_14350	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
AHiyo4_14360	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
AHiyo4_14370	ENOG4107XT7	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
AHiyo4_14380	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
AHiyo4_14390	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
AHiyo4_14450	ENOG4108UNV	SUF system FeS assembly protein, NifU family
AHiyo4_14460	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
AHiyo4_14510	ENOG4105CGD	Nad-dependent epimerase dehydratase
AHiyo4_14540	ENOG4107K5X	Membrane-bound metal-dependent hydrolase
AHiyo4_14570	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
AHiyo4_14630	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
AHiyo4_14640	ENOG4107QZF	nitrite reductase NADPH large subunit
AHiyo4_14650	ENOG4107QZF	nitrite reductase NADPH large subunit
AHiyo4_14670	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
AHiyo4_14680	ENOG410847I	Transcriptional regulator, BadM Rrf2 family
AHiyo4_14750	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
AHiyo4_14760	ENOG4107QND	Nitrite extrusion protein
AHiyo4_14770	ENOG4105CSH	Transporter
AHiyo4_14800	ENOG4108JIK	carboxylase
AHiyo4_14820	ENOG4107WR6	Maf-like protein
AHiyo4_14830	ENOG4105EYF	MMPL domain protein
AHiyo4_14840	ENOG4105EYF	MMPL domain protein
AHiyo4_14880	ENOG4108ETY	sodium dicarboxylate symporter
AHiyo4_14920	ENOG4105D8K	carboxyl transferase
AHiyo4_14930	ENOG4105D8K	carboxyl transferase
AHiyo4_14960	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
AHiyo4_15060	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
AHiyo4_15150	ENOG4108ZF3	Phosphatase
AHiyo4_15220	ENOG4105EC2	ftsk spoIIIe
AHiyo4_15230	ENOG4105EC2	ftsk spoIIIe
AHiyo4_15280	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
AHiyo4_15290	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
AHiyo4_15300	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
AHiyo4_15310	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
AHiyo4_15320	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
AHiyo4_15350	ENOG4108176	endoribonuclease L-psp
AHiyo4_15360	ENOG4108MRH	transcriptional regulatory protein
AHiyo4_15390	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
AHiyo4_15400	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
AHiyo4_15410	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
AHiyo4_15420	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
AHiyo4_15460	ENOG4105CPQ	Dehydrogenase
AHiyo4_15470	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
AHiyo4_15490	ENOG4105FC8	fad dependent oxidoreductase
AHiyo4_15500	ENOG4105CI2	imidazolone-5-propionate hydrolase
AHiyo4_15510	ENOG4105CI2	imidazolone-5-propionate hydrolase
AHiyo4_15590	ENOG4105DWV	Homoserine O-trans-acetylase
AHiyo4_15600	ENOG4105DWV	Homoserine O-trans-acetylase
AHiyo4_15610	ENOG4105DWV	Homoserine O-trans-acetylase
AHiyo4_15680	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
AHiyo4_15700	ENOG4105C26	Dehydrogenase
AHiyo4_15710	ENOG4105C26	Dehydrogenase
AHiyo4_15730	ENOG41090WU	lipolytic protein G-D-S-L family
AHiyo4_15740	ENOG4105FBA	Phospholipase Carboxylesterase
AHiyo4_15760	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
AHiyo4_15870	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
AHiyo4_15880	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
AHiyo4_15890	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
AHiyo4_15900	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
AHiyo4_15970	ENOG4105C2C	drug resistance transporter, Bcr CflA
AHiyo4_15990	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
AHiyo4_16040	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
AHiyo4_16050	ENOG4105C1G	acyl-Coa dehydrogenase
AHiyo4_16080	ENOG4105CE9	30S ribosomal protein S2
AHiyo4_16090	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
AHiyo4_16100	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
AHiyo4_16110	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
AHiyo4_16130	ENOG4105KNE	Phosphatidate cytidylyltransferase
AHiyo4_16180	ENOG4108NEV	two component transcriptional regulator, LytTR family
AHiyo4_16190	ENOG4108HRK	Histidine kinase
AHiyo4_16210	ENOG4107QN1	sodium solute
AHiyo4_16260	ENOG4105CPP	Dehydrogenase, E1 component
AHiyo4_16270	ENOG4105CPP	Dehydrogenase, E1 component
AHiyo4_16280	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
AHiyo4_16300	ENOG4107QX3	carboxylase
AHiyo4_16350	ENOG4105C1G	acyl-Coa dehydrogenase
AHiyo4_16470	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
AHiyo4_16480	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
AHiyo4_16490	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
AHiyo4_16500	ENOG4105DZP	Membrane-associated zinc metalloprotease
AHiyo4_16530	ENOG4105DZP	Membrane-associated zinc metalloprotease
AHiyo4_16590	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
AHiyo4_16620	ENOG4108IG5	Transcriptional regulator
AHiyo4_16660	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
AHiyo4_16670	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
AHiyo4_16740	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
AHiyo4_16750	ENOG4105CHV	Transcription elongation factor NusA
AHiyo4_16780	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
AHiyo4_16800	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
AHiyo4_16810	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
AHiyo4_16820	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
AHiyo4_16840	ENOG4107Y2X	deaminase
AHiyo4_16860	ENOG4105CHM	Aminotransferase
AHiyo4_16880	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
AHiyo4_16900	ENOG4105DTN	riboflavin biosynthesis protein ribF
AHiyo4_16920	ENOG4105HJ8	Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity)
AHiyo4_16940	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
AHiyo4_16950	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
AHiyo4_16960	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
AHiyo4_16970	ENOG4105C1V	Peptidase, M16
AHiyo4_16980	ENOG4105C1V	Peptidase, M16
AHiyo4_17020	ENOG4108UDW	Transcriptional regulator, luxr family
AHiyo4_17150	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
AHiyo4_17160	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
AHiyo4_17180	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
AHiyo4_17240	ENOG4105C4K	Nad synthetase
AHiyo4_17250	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
AHiyo4_17260	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
AHiyo4_17280	ENOG4105CN5	Metallo-Beta-Lactamase
AHiyo4_17290	ENOG4107QZI	cell division protein FtsK
AHiyo4_17300	ENOG4107QZI	cell division protein FtsK
AHiyo4_17330	ENOG4105CEV	competence damage-inducible protein
AHiyo4_17350	ENOG4105WBV	Transcriptional regulator
AHiyo4_17370	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
AHiyo4_17380	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
AHiyo4_17390	ENOG4105KC9	Modulates RecA activity (By similarity)
AHiyo4_17400	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
AHiyo4_17410	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
AHiyo4_17420	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
AHiyo4_17430	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
AHiyo4_17440	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
AHiyo4_17450	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
AHiyo4_17460	ENOG4107Y49	methyltransferase
AHiyo4_17470	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
AHiyo4_17490	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
AHiyo4_17510	ENOG4105CIH	Imidazole acetol-phosphate transaminase
AHiyo4_17520	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
AHiyo4_17530	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
AHiyo4_17540	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
AHiyo4_17560	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
AHiyo4_17610	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
AHiyo4_17620	ENOG41084BS	50S ribosomal protein L35
AHiyo4_17630	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
AHiyo4_17640	ENOG4108RWN	rrna methyltransferase
AHiyo4_17670	ENOG4105F27	Major Facilitator
AHiyo4_17680	ENOG4105F27	Major Facilitator
AHiyo4_17690	ENOG4105F27	Major Facilitator
AHiyo4_17740	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
AHiyo4_17750	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
AHiyo4_17760	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
AHiyo4_17770	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
AHiyo4_17820	ENOG4105C0W	non-ribosomal peptide synthetase
AHiyo4_17840	ENOG4105CEY	Amp-dependent synthetase and ligase
AHiyo4_17850	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
AHiyo4_17890	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
AHiyo4_17900	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
AHiyo4_17910	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
AHiyo4_17920	ENOG4105CAS	nag kinase
AHiyo4_17930	ENOG4105C8Y	Acetylornithine aminotransferase
AHiyo4_17940	ENOG4105DBV	ornithine carbamoyltransferase
AHiyo4_17950	ENOG4105DBV	ornithine carbamoyltransferase
AHiyo4_17960	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
AHiyo4_17970	ENOG4105CDH	Citrulline--aspartate ligase
AHiyo4_17980	ENOG4105CH7	arginosuccinase
AHiyo4_18010	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
AHiyo4_18040	ENOG4108VX5	3-methyladenine DNA glycosylase
AHiyo4_18080	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
AHiyo4_18110	ENOG4105DSU	hydrolase
AHiyo4_18160	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
AHiyo4_18170	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
AHiyo4_18180	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
AHiyo4_18190	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
AHiyo4_18200	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
AHiyo4_18260	ENOG4105DXD	2-methylcitrate dehydratase
AHiyo4_18310	ENOG4105C5R	Aminotransferase
AHiyo4_18320	ENOG4105C5R	Aminotransferase
AHiyo4_18330	ENOG4108MRH	transcriptional regulatory protein
AHiyo4_18350	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
AHiyo4_18370	ENOG4105CK2	sodium dicarboxylate symporter
AHiyo4_18380	ENOG4105CK2	sodium dicarboxylate symporter
AHiyo4_18400	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
AHiyo4_18410	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
AHiyo4_18450	ENOG4105CAT	Cytidine monophosphate kinase
AHiyo4_18460	ENOG4105CAT	Cytidine monophosphate kinase
AHiyo4_18480	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
AHiyo4_18540	ENOG4108UW8	fha domain-containing protein
AHiyo4_18610	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
AHiyo4_18620	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
AHiyo4_18630	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
AHiyo4_18660	ENOG4105DKQ	ROK family
AHiyo4_18670	ENOG4105DKQ	ROK family
AHiyo4_18760	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
AHiyo4_18790	ENOG4105D9P	serine threonine protein kinase
AHiyo4_18810	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
AHiyo4_18820	ENOG41068JE	domain protein
AHiyo4_18880	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
AHiyo4_18890	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
AHiyo4_18910	ENOG4108V6E	Cell division protein mraZ
AHiyo4_18920	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
AHiyo4_18930	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
AHiyo4_18960	ENOG4105CJN	penicillin-binding protein
AHiyo4_18970	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
AHiyo4_18980	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
AHiyo4_18990	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
AHiyo4_19010	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
AHiyo4_19020	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
AHiyo4_19030	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
AHiyo4_19040	ENOG4105CNI	cell division protein FtsW
AHiyo4_19050	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
AHiyo4_19060	ENOG4105DFU	Cell wall formation (By similarity)
AHiyo4_19070	ENOG4105ME9	cell division protein FtsQ
AHiyo4_19090	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
AHiyo4_19110	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
AHiyo4_19120	ENOG4105DFA	alanine racemase domain protein
AHiyo4_19130	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
AHiyo4_19160	ENOG4107ZIW	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
AHiyo4_19190	ENOG4105C0B	DNA polymerase III (alpha subunit)
AHiyo4_19200	ENOG4105C0B	DNA polymerase III (alpha subunit)
AHiyo4_19230	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
AHiyo4_19240	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
AHiyo4_19280	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
AHiyo4_19290	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
AHiyo4_19300	ENOG4105C5F	glutamine synthetase
AHiyo4_19320	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
AHiyo4_19340	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
AHiyo4_19400	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
AHiyo4_19410	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
AHiyo4_19420	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
AHiyo4_19460	ENOG4105ECP	epimerase
AHiyo4_19480	ENOG4107RE3	peptidase, S41
AHiyo4_19490	ENOG4107RE3	peptidase, S41
AHiyo4_19500	ENOG4107RE3	peptidase, S41
AHiyo4_19510	ENOG4107RE3	peptidase, S41
AHiyo4_19520	ENOG4107RE3	peptidase, S41
AHiyo4_19600	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
AHiyo4_19680	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
AHiyo4_19710	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AHiyo4_19720	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AHiyo4_19750	ENOG4105C4M	(Ubiquinol oxidase) subunit I
AHiyo4_19760	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
AHiyo4_19770	ENOG4108JJ9	ABC, transporter
AHiyo4_19780	ENOG4108JJ9	ABC, transporter
AHiyo4_19790	ENOG4105CJ1	ABC, transporter
AHiyo4_19800	ENOG4108JJ8	(ABC) transporter
AHiyo4_19850	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AHiyo4_19870	ENOG410870F	Cyclic nucleotide-binding protein
AHiyo4_19970	ENOG4107ZFB	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
AHiyo4_20030	ENOG4107VEG	TrkA-N domain protein
AHiyo4_20040	ENOG4105C0X	amino acid
AHiyo4_20050	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
AHiyo4_20070	ENOG4107QM5	aconitate hydratase
AHiyo4_20080	ENOG4107QM5	aconitate hydratase
AHiyo4_20090	ENOG4107QM5	aconitate hydratase
AHiyo4_20100	ENOG4107QM5	aconitate hydratase
AHiyo4_20110	ENOG4107QM5	aconitate hydratase
AHiyo4_20120	ENOG4107QM5	aconitate hydratase
AHiyo4_20130	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
AHiyo4_20140	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
AHiyo4_20150	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
AHiyo4_20180	ENOG4107SET	aldo keto reductase
AHiyo4_20250	ENOG4108JJB	ABC transporter
AHiyo4_20260	ENOG4108JJB	ABC transporter
AHiyo4_20270	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
AHiyo4_20280	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
AHiyo4_20300	ENOG4105CHU	acetyl-coa acetyltransferase
AHiyo4_20310	ENOG4105CHU	acetyl-coa acetyltransferase
AHiyo4_20330	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
AHiyo4_20390	ENOG4105E0X	reductase
AHiyo4_20450	ENOG4108Z66	YbaK ebsC protein
AHiyo4_20530	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
AHiyo4_20540	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
AHiyo4_20550	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
AHiyo4_20560	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
AHiyo4_20580	ENOG4105DJV	ribulose-phosphate 3-epimerase
AHiyo4_20600	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
AHiyo4_20650	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
AHiyo4_20660	ENOG4107QJN	gtp cyclohydrolase ii
AHiyo4_20670	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
AHiyo4_20680	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
AHiyo4_20690	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
AHiyo4_20700	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
AHiyo4_20720	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
AHiyo4_20770	ENOG4105DK0	Indole-3-glycerol phosphate synthase
AHiyo4_20790	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
AHiyo4_20800	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
AHiyo4_20820	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
AHiyo4_20830	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
AHiyo4_20850	ENOG4105CBC	glutamate synthase
AHiyo4_20860	ENOG4105CBC	glutamate synthase
AHiyo4_20870	ENOG4105CBC	glutamate synthase
AHiyo4_20890	ENOG4105CBC	glutamate synthase
AHiyo4_20900	ENOG4105CBC	glutamate synthase
AHiyo4_21230	ENOG41070H7	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
AHiyo4_21250	ENOG41070H7	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
AHiyo4_21270	ENOG4105CPQ	Dehydrogenase
AHiyo4_21310	ENOG4108ZFP	monooxygenase component MmoB DmpM
AHiyo4_21320	ENOG4105CKQ	methane phenol toluene hydroxylase
AHiyo4_21390	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
AHiyo4_21520	ENOG4106F59	XRE family Transcriptional regulator
AHiyo4_21530	ENOG4106A3M	Cytochrome p-450
AHiyo4_21560	ENOG4107WHG	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
AHiyo4_21570	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
AHiyo4_21580	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
AHiyo4_21600	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
AHiyo4_21620	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
AHiyo4_21630	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
AHiyo4_21660	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AHiyo4_21720	ENOG4105C32	Amino acid ABC transporter (Permease)
AHiyo4_21740	ENOG4105C32	Amino acid ABC transporter (Permease)
AHiyo4_21750	ENOG4105C32	Amino acid ABC transporter (Permease)
AHiyo4_21760	ENOG4105C0Z	ABC transporter
AHiyo4_21770	ENOG4108IV0	ABC, transporter
AHiyo4_21830	ENOG4107EFR	Flavocytochrome c
AHiyo4_21850	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
AHiyo4_21870	ENOG4108PGP	mmge prpd family protein
AHiyo4_21890	ENOG4105CD3	dihydroorotase
AHiyo4_21990	ENOG4105DQE	DNA ligase
AHiyo4_22160	ENOG4105C93	Xylose Isomerase
AHiyo4_22170	ENOG4105C93	Xylose Isomerase
AHiyo4_22180	ENOG4105QE3	oxidoreductase
AHiyo4_22250	ENOG4105HFS	5'-3' exonuclease
AHiyo4_22260	ENOG4105HFS	5'-3' exonuclease
AHiyo4_22360	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
AHiyo4_22420	ENOG4105CQ7	ATP-dependent helicase
AHiyo4_22430	ENOG4105CQ7	ATP-dependent helicase
AHiyo4_22470	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
AHiyo4_22600	ENOG4108TZA	Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity)
AHiyo4_22650	ENOG4105C2M	dna polymerase I
AHiyo4_22660	ENOG4105HHS	UPF0256 protein
AHiyo4_22670	ENOG4105HHS	UPF0256 protein
AHiyo4_22680	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
AHiyo4_22720	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
AHiyo4_22730	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
AHiyo4_22740	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
AHiyo4_22770	ENOG4105DXI	Major Facilitator superfamily
AHiyo4_22880	ENOG4107R6G	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity)
AHiyo4_22890	ENOG4105BZ1	(ABC) transporter
AHiyo4_22940	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
AHiyo4_22950	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
AHiyo4_22970	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
AHiyo4_22990	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
AHiyo4_23010	ENOG4105CIE	May be required for sporulation (By similarity)
AHiyo4_23020	ENOG4105CIE	May be required for sporulation (By similarity)
AHiyo4_23030	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
AHiyo4_23040	ENOG4105BZA	Phosphoglycerate kinase
AHiyo4_23050	ENOG4105CP7	Triose-phosphate isomerase
AHiyo4_23080	ENOG4107XU2	6-phosphogluconolactonase (EC 3.1.1.31)
AHiyo4_23120	ENOG4105C89	phosphohexose isomerase
AHiyo4_23130	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
AHiyo4_23140	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
AHiyo4_23170	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
AHiyo4_23190	ENOG4107SGF	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
AHiyo4_23220	ENOG4105CJ1	ABC, transporter
AHiyo4_23240	ENOG4105DIW	FeS assembly protein SUFB
AHiyo4_23260	ENOG4105JRK	feS assembly protein SufD
AHiyo4_23280	ENOG4105VQD	rieske 2fe-2S domain-containing protein
AHiyo4_23290	ENOG4105C3K	feS assembly ATPase SufC
AHiyo4_23300	ENOG4105C3K	feS assembly ATPase SufC
AHiyo4_23310	ENOG4105VG1	fes assembly suf system protein
AHiyo4_23340	ENOG4105CEY	Amp-dependent synthetase and ligase
AHiyo4_23360	ENOG4105CHU	acetyl-coa acetyltransferase
AHiyo4_23390	ENOG4108JJB	ABC transporter
AHiyo4_23400	ENOG4107ZYJ	bioY protein
AHiyo4_23410	ENOG4105C5H	ABC transporter
AHiyo4_23420	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
AHiyo4_23470	ENOG4105CHR	reductase
AHiyo4_23480	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
AHiyo4_23510	ENOG4105EAC	phosphoserine phosphatase
AHiyo4_23520	ENOG4105DKW	ABC transporter
AHiyo4_23560	ENOG4105XPP	Protein of unknown function (DUF1275)
AHiyo4_23630	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
AHiyo4_23670	ENOG4105NRA	50s ribosomal protein l31 type b
AHiyo4_23700	ENOG4107ZR7	Membrane
AHiyo4_23780	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
AHiyo4_23790	ENOG4107QPH	glycogen) synthase
AHiyo4_23800	ENOG4107QPH	glycogen) synthase
AHiyo4_23860	ENOG4105CHU	acetyl-coa acetyltransferase
AHiyo4_23870	ENOG4105CHU	acetyl-coa acetyltransferase
AHiyo4_23880	ENOG4105CHR	reductase
AHiyo4_23950	ENOG4105CHF	Glutathione S-transferase
AHiyo4_24010	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
AHiyo4_24050	ENOG4105CPC	Aldo Keto reductase
AHiyo4_24060	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
AHiyo4_24070	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
AHiyo4_24080	ENOG4105C8N	cysteinyl-tRNA synthetase
AHiyo4_24100	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
AHiyo4_24130	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
AHiyo4_24140	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
AHiyo4_24150	ENOG4105E5F	proteasome
AHiyo4_24160	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
AHiyo4_24170	ENOG4105F7N	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
AHiyo4_24180	ENOG4105F7N	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
AHiyo4_24190	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
AHiyo4_24200	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
AHiyo4_24210	ENOG4108V1T	peptidylprolyl cis-trans isomerase
AHiyo4_24240	ENOG4108FFZ	Transcriptional regulator
AHiyo4_24310	ENOG4105CQR	helicase
AHiyo4_24340	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
AHiyo4_24350	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
AHiyo4_24430	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
AHiyo4_24440	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
AHiyo4_24450	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
AHiyo4_24470	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
AHiyo4_24480	ENOG4105E2Q	3-(3-hydroxy-phenyl)propionate hydroxylase
AHiyo4_24520	ENOG41065KQ	synthase
AHiyo4_24590	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
AHiyo4_24640	ENOG4108I0Q	anthranilate phosphoribosyltransferase
AHiyo4_24650	ENOG4105CCU	oxidase (Subunit III)
AHiyo4_24660	ENOG4105CCU	oxidase (Subunit III)
AHiyo4_24670	ENOG4105Z6S	cytochrome C, class I
AHiyo4_24690	ENOG4107EUI	c reductase, iron-sulfur
AHiyo4_24700	ENOG4107EUI	c reductase, iron-sulfur
AHiyo4_24710	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
AHiyo4_24720	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
AHiyo4_24750	ENOG4105MCD	Part of cytochrome c oxidase, its function is
AHiyo4_24760	ENOG4105BZ9	Cytochrome C oxidase, subunit I
AHiyo4_24780	ENOG4105BZ9	Cytochrome C oxidase, subunit I
AHiyo4_24790	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
AHiyo4_24840	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
AHiyo4_24860	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
AHiyo4_24870	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
AHiyo4_24880	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
AHiyo4_24890	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
AHiyo4_24900	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
AHiyo4_24910	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
AHiyo4_24920	ENOG4105C9K	Endothelin-converting enzyme 1
AHiyo4_24930	ENOG4107TB5	TRANSCRIPTIONal
AHiyo4_24940	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
AHiyo4_24950	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
AHiyo4_24970	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
AHiyo4_24980	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
AHiyo4_25030	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
AHiyo4_25040	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
AHiyo4_25060	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
AHiyo4_25070	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
AHiyo4_25130	ENOG4105CSA	Coproporphyrinogen iii oxidase
AHiyo4_25150	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
AHiyo4_25160	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
AHiyo4_25170	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
AHiyo4_25190	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
AHiyo4_25280	ENOG4105EPR	degv family
AHiyo4_25290	ENOG4105EPR	degv family
AHiyo4_25300	ENOG4105C8T	Leucyl-tRNA synthetase
AHiyo4_25370	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
AHiyo4_25380	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
AHiyo4_25390	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
AHiyo4_25440	ENOG4105CV8	reductase
AHiyo4_25460	ENOG4105E2K	Glycosyl transferase (Group 1
AHiyo4_25490	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
AHiyo4_25510	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
AHiyo4_25520	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
AHiyo4_25530	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
AHiyo4_25540	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
AHiyo4_25560	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
AHiyo4_25570	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
AHiyo4_25590	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
AHiyo4_25600	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
AHiyo4_25620	ENOG4105CD3	dihydroorotase
AHiyo4_25630	ENOG4105CD3	dihydroorotase
AHiyo4_25640	ENOG4105CD3	dihydroorotase
AHiyo4_25650	ENOG4105CXT	aspartate transcarbamylase
AHiyo4_25660	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
AHiyo4_25720	ENOG4105F5W	AtP-binding protein
AHiyo4_25760	ENOG410803B	Involved in the transcription termination process (By similarity)
AHiyo4_25770	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
AHiyo4_25780	ENOG4105D49	3-dehydroquinate synthase
AHiyo4_25790	ENOG4105D49	3-dehydroquinate synthase
AHiyo4_25810	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
AHiyo4_25820	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
AHiyo4_25830	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
AHiyo4_25840	ENOG4107YNV	3-dehydroquinate dehydratase
AHiyo4_25850	ENOG4105E2X	shikimate dehydrogenase
AHiyo4_25880	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
AHiyo4_25890	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
AHiyo4_25900	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
AHiyo4_25910	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
AHiyo4_25920	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
AHiyo4_25930	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
AHiyo4_25970	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
AHiyo4_26010	ENOG4105C9M	aspartyl-trna synthetase
AHiyo4_26020	ENOG4105C9M	aspartyl-trna synthetase
AHiyo4_26030	ENOG4105C9M	aspartyl-trna synthetase
AHiyo4_26070	ENOG4105CUT	histidyl-tRNA synthetase
AHiyo4_26110	ENOG4105C99	atpase involved in dna repair
AHiyo4_26130	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
AHiyo4_26150	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
AHiyo4_26160	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
AHiyo4_26170	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
AHiyo4_26180	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
AHiyo4_26200	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
AHiyo4_26210	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
AHiyo4_26220	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
AHiyo4_26230	ENOG4105CDY	transcriptional regulatory protein
AHiyo4_26240	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
AHiyo4_26250	ENOG4105DMS	mur ligase
AHiyo4_26290	ENOG4105DGW	oligopeptidase A
AHiyo4_26300	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
AHiyo4_26310	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
AHiyo4_26320	ENOG4108VTU	Cdp-alcohol phosphatidyltransferase
AHiyo4_26340	ENOG4105C22	threonyL-tRNA synthetase
AHiyo4_26350	ENOG4105C22	threonyL-tRNA synthetase
AHiyo4_26370	ENOG4105C0B	DNA polymerase III (alpha subunit)
AHiyo4_26390	ENOG4105C0B	DNA polymerase III (alpha subunit)
AHiyo4_26470	ENOG4108RAV	Conserved protein
AHiyo4_26600	ENOG4108JW7	Maf-like protein
AHiyo4_26690	ENOG4105CNG	UPF0061 protein
AHiyo4_26730	ENOG4108KC1	acyl-Coa dehydrogenase
AHiyo4_26750	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
AHiyo4_26820	ENOG4108R85	Short chain dehydrogenase
AHiyo4_26860	ENOG4108UDB	Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity)
AHiyo4_27000	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
AHiyo4_27020	ENOG4105CIG	ABC transporter
AHiyo4_27100	ENOG4105IJJ	transcriptional regulator, crp fnr family
AHiyo4_27130	ENOG4107R6G	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity)
AHiyo4_27160	ENOG4107QN2	dihydrolipoyl dehydrogenase
AHiyo4_27190	ENOG4107YCR	Transcriptional regulator, ARSR family
AHiyo4_27390	ENOG4108C33	Resolvase
AHiyo4_27420	ENOG4108C33	Resolvase
AHiyo4_27520	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
AHiyo4_27530	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
AHiyo4_27540	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
AHiyo4_27590	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
AHiyo4_27600	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
AHiyo4_27630	ENOG4105BZ8	glutamate synthase
AHiyo4_27640	ENOG4107NQ8	LysR family Transcriptional regulator
AHiyo4_27680	ENOG4107QYE	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
AHiyo4_27770	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
AHiyo4_27800	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
AHiyo4_27880	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
AHiyo4_27890	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
AHiyo4_27900	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
AHiyo4_27910	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
AHiyo4_27950	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
AHiyo4_27970	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
AHiyo4_27980	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
AHiyo4_27990	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
AHiyo4_28000	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
AHiyo4_28010	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
AHiyo4_28020	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AHiyo4_28040	ENOG4105K46	50S ribosomal protein l27
AHiyo4_28050	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
AHiyo4_28060	ENOG4105DWF	phosphomethylpyrimidine kinase
AHiyo4_28080	ENOG4105C03	ribonuclease
AHiyo4_28090	ENOG4105C03	ribonuclease
AHiyo4_28140	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
AHiyo4_28150	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
AHiyo4_28160	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
AHiyo4_28170	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
AHiyo4_28180	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
AHiyo4_28210	ENOG4108BAS	reductase
AHiyo4_28230	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
AHiyo4_28240	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
AHiyo4_28250	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
AHiyo4_28260	ENOG4105MC2	DSBA oxidoreductase
AHiyo4_28270	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
AHiyo4_28280	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
AHiyo4_28290	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
AHiyo4_28300	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
AHiyo4_28310	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
AHiyo4_28430	ENOG4105D8X	mechanosensitive ion channel
AHiyo4_28450	ENOG4105C29	acyl-CoA thioesterase
AHiyo4_28540	ENOG4105ETE	Transcriptional regulator (LacI family
AHiyo4_28570	ENOG4107JC6	Membrane
AHiyo4_28590	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
AHiyo4_28600	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
AHiyo4_28670	ENOG4105EGD	dinuclear metal center protein, YbgI family
AHiyo4_28680	ENOG4105EGD	dinuclear metal center protein, YbgI family
AHiyo4_28690	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
AHiyo4_28710	ENOG4105D7W	serine acetyltransferase
AHiyo4_28720	ENOG4105E1F	short-chain dehydrogenase reductase
AHiyo4_28730	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
AHiyo4_28770	ENOG4105CPQ	Dehydrogenase
AHiyo4_28780	ENOG4105CPQ	Dehydrogenase
AHiyo4_28790	ENOG4105CPQ	Dehydrogenase
AHiyo4_28800	ENOG4105CHR	reductase
AHiyo4_28840	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
AHiyo4_28920	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
AHiyo4_28930	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
AHiyo4_28940	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
AHiyo4_28980	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
AHiyo4_28990	ENOG41082KT	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
AHiyo4_29000	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
AHiyo4_29030	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AHiyo4_29070	ENOG41080R2	UPF0102 protein
AHiyo4_29090	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
AHiyo4_29110	ENOG4107QYR	Signal peptidase i
AHiyo4_29130	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
AHiyo4_29140	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
AHiyo4_29150	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
AHiyo4_29160	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
AHiyo4_29170	ENOG4105K5M	30s ribosomal protein S16
AHiyo4_29190	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
AHiyo4_29200	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
AHiyo4_29220	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
AHiyo4_29290	ENOG4105BZU	Histidine kinase
AHiyo4_29330	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
AHiyo4_29340	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
AHiyo4_29350	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
AHiyo4_29380	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
AHiyo4_29400	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
AHiyo4_29410	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
AHiyo4_29420	ENOG41062IY	50S ribosomal protein L32
AHiyo4_29450	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
AHiyo4_29460	ENOG4105CHM	Aminotransferase
AHiyo4_29480	ENOG4106H78	methyltransferase
AHiyo4_29580	ENOG4105CPF	Cell wall formation (By similarity)
AHiyo4_29590	ENOG4105CPF	Cell wall formation (By similarity)
AHiyo4_29610	ENOG4105CPF	Cell wall formation (By similarity)
AHiyo4_29620	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
AHiyo4_29630	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
AHiyo4_29640	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
AHiyo4_29660	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
AHiyo4_29670	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
AHiyo4_29680	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
AHiyo4_29700	ENOG41069M3	Transcriptional regulator
AHiyo4_29810	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
AHiyo4_29820	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
AHiyo4_29890	ENOG4105CM2	brancheD-chain amino acid aminotransferase
AHiyo4_29900	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
AHiyo4_29950	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
AHiyo4_30000	ENOG4108JQ1	Dehydrogenase
AHiyo4_30010	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
AHiyo4_30020	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
AHiyo4_30030	ENOG4108ZP8	Acetolactate synthase small subunit
AHiyo4_30040	ENOG4105C7K	acetolactate synthase
AHiyo4_30070	ENOG4105C01	Dihydroxy-acid dehydratase
AHiyo4_30090	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
AHiyo4_30110	ENOG4105D8V	Glucose sorbosone dehydrogenase
AHiyo4_30170	ENOG4105DWT	malate dehydrogenase (quinone)
AHiyo4_30200	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
AHiyo4_30250	ENOG4105ERH	Fumarylacetoacetate hydrolase
AHiyo4_30280	ENOG4105C3J	Cysteine desulfurase
AHiyo4_30290	ENOG4107QI6	Cysteine desulfurase
AHiyo4_30300	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
AHiyo4_30330	ENOG4108IYU	L-aspartate oxidase
AHiyo4_30340	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
AHiyo4_30350	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
AHiyo4_30360	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
AHiyo4_30380	ENOG4105C85	amino acid
AHiyo4_30390	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
AHiyo4_30400	ENOG4108EMS	branched-chain alpha-keto acid dehydrogenase subunit E2
AHiyo4_30440	ENOG4108FUF	Transcriptional regulator, IclR family
AHiyo4_30490	ENOG4105EYH	Exonuclease
AHiyo4_30510	ENOG4105EYH	Exonuclease
AHiyo4_30540	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
AHiyo4_30580	ENOG4107XFB	conserved TRANSMEMBRANE PROTEIN
AHiyo4_30600	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
AHiyo4_30620	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
AHiyo4_30640	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
AHiyo4_30660	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
AHiyo4_30690	ENOG4108RWI	nicotinamidase
AHiyo4_30710	ENOG4105F8X	type iii restriction
AHiyo4_30740	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
AHiyo4_30900	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
AHiyo4_30920	ENOG4105FF5	Membrane
AHiyo4_30930	ENOG4108SEA	Esterase
AHiyo4_30950	ENOG410825K	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
AHiyo4_30960	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
AHiyo4_30970	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
AHiyo4_30980	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
AHiyo4_30990	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
AHiyo4_31010	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
AHiyo4_31020	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
AHiyo4_31030	ENOG4106DE0	ATP synthase
AHiyo4_31040	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
AHiyo4_31080	ENOG4105ESV	Glycosyl transferase, family 4
AHiyo4_31090	ENOG4108MKI	Glycosyl transferase, family 2
AHiyo4_31160	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
AHiyo4_31190	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
AHiyo4_31200	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
AHiyo4_31210	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
AHiyo4_31220	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
AHiyo4_31230	ENOG4105D6E	homoserine dehydrogenase
AHiyo4_31240	ENOG4105D6E	homoserine dehydrogenase
AHiyo4_31250	ENOG4105D6E	homoserine dehydrogenase
AHiyo4_31260	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
AHiyo4_31280	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
AHiyo4_31290	ENOG4105C75	arginyL-tRNA synthetase
AHiyo4_31360	ENOG4105D4Y	metalloprotease
AHiyo4_31400	ENOG4105CQ7	ATP-dependent helicase
AHiyo4_31410	ENOG4105CQ7	ATP-dependent helicase
AHiyo4_31420	ENOG4105CQ7	ATP-dependent helicase
AHiyo4_31430	ENOG4105CQ7	ATP-dependent helicase
AHiyo4_31440	ENOG4105CQ7	ATP-dependent helicase
AHiyo4_31450	ENOG4105CQ7	ATP-dependent helicase
AHiyo4_31470	ENOG4105DQ4	alcohol dehydrogenase
AHiyo4_31480	ENOG4105DQ4	alcohol dehydrogenase
AHiyo4_31490	ENOG4105KHC	sulfurtransferase
AHiyo4_31550	ENOG4105CC5	ABC transporter
AHiyo4_31570	ENOG4108UCS	ABC, transporter
AHiyo4_31600	ENOG4105DSE	periplasmic solute binding protein
AHiyo4_31640	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
AHiyo4_31650	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
AHiyo4_31660	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
AHiyo4_31710	ENOG4105EMN	RNA polymerase sigma factor
AHiyo4_31720	ENOG4105EMN	RNA polymerase sigma factor
AHiyo4_31760	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
AHiyo4_31770	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
AHiyo4_31800	ENOG4107TK4	histidinol-phosphate phosphatase
AHiyo4_31810	ENOG4105C9B	Cysteine desulfurase
AHiyo4_31820	ENOG4105C9B	Cysteine desulfurase
AHiyo4_31870	ENOG410814D	Protein CrcB homolog
AHiyo4_31900	ENOG4105C0H	protease
AHiyo4_31920	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
AHiyo4_31950	ENOG4105CAK	Cell division ATP-binding protein ftsE
AHiyo4_31960	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
AHiyo4_32090	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
AHiyo4_32110	ENOG4105C5E	polysaccharide biosynthesis protein
AHiyo4_32120	ENOG4105C5E	polysaccharide biosynthesis protein
AHiyo4_32130	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
AHiyo4_32180	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
AHiyo4_32200	ENOG4107QPT	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
AHiyo4_32260	ENOG4105CKK	Glycosyl transferase, family 2
AHiyo4_32270	ENOG4105CMR	udp-glucose 4-epimerase
AHiyo4_32290	ENOG4105K64	Glycosyl transferase, family 2
AHiyo4_32330	ENOG4105EY8	ABC transporter
AHiyo4_32360	ENOG410602S	Transferase
AHiyo4_32380	ENOG4105EC2	ftsk spoIIIe
AHiyo4_32390	ENOG4105EC2	ftsk spoIIIe
AHiyo4_32460	ENOG4105C7I	Dehydrogenase
AHiyo4_32470	ENOG4105C7I	Dehydrogenase
AHiyo4_32480	ENOG4105C7I	Dehydrogenase
AHiyo4_32490	ENOG4105C7I	Dehydrogenase
AHiyo4_32580	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
AHiyo4_32590	ENOG4105T0Z	Conserved Protein
AHiyo4_32600	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
AHiyo4_32620	ENOG4108T3R	lipoprotein lpqB
AHiyo4_32630	ENOG4105BZU	Histidine kinase
AHiyo4_32640	ENOG4105BZU	Histidine kinase
AHiyo4_32680	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AHiyo4_32740	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
AHiyo4_32800	ENOG4108JQ6	ABC transporter
AHiyo4_32810	ENOG4105C3U	ABC transporter
AHiyo4_32830	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
AHiyo4_32870	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
AHiyo4_32880	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
AHiyo4_32970	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
AHiyo4_32980	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
AHiyo4_32990	ENOG4105K6V	RNA polymerase
AHiyo4_33020	ENOG4105C10	Electron transfer flavoprotein
AHiyo4_33040	ENOG4105C0H	protease
AHiyo4_33060	ENOG41087YS	Phage shock protein A
AHiyo4_33070	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
AHiyo4_33080	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
AHiyo4_33100	ENOG4105DJZ	UPF0182 protein
AHiyo4_33110	ENOG4105DJZ	UPF0182 protein
AHiyo4_33120	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
AHiyo4_33160	ENOG4105NAE	bifunctional deaminase-reductase domain protein
AHiyo4_33220	ENOG4105E09	nadh pyrophosphatase
AHiyo4_33360	ENOG4106TNF	Periplasmic binding protein
AHiyo4_33380	ENOG4105E5Q	amino acid AbC transporter
AHiyo4_33390	ENOG4105CDA	abc transporter atp-binding protein
AHiyo4_33400	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
AHiyo4_33420	ENOG4105D52	delta-aminolevulinic acid dehydratase
AHiyo4_33450	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
AHiyo4_33460	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
AHiyo4_33470	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
AHiyo4_33480	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
AHiyo4_33490	ENOG4107JTW	chlorite dismutase
AHiyo4_33540	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
AHiyo4_33560	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
AHiyo4_33620	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
AHiyo4_33630	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
AHiyo4_33660	ENOG41080HI	glycine oxidase
AHiyo4_33670	ENOG4107Y5I	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
AHiyo4_33700	ENOG4105C1J	atp-dependent rna helicase
AHiyo4_33770	ENOG4107T6F	Xaa-Pro aminopeptidase
AHiyo4_33820	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
AHiyo4_33870	ENOG4105UTW	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
AHiyo4_33890	ENOG4105DU6	RNA polymerase
AHiyo4_33940	ENOG4108URH	decarboxylase
AHiyo4_33950	ENOG4105CDA	abc transporter atp-binding protein
AHiyo4_33960	ENOG4105CDA	abc transporter atp-binding protein
AHiyo4_33970	ENOG4107UBR	Extracellular solute-binding protein family 3
AHiyo4_34000	ENOG4105EAD	ABC transporter
AHiyo4_34020	ENOG4105DRP	amino acid AbC transporter
AHiyo4_34030	ENOG4107R4C	succinyl-diaminopimelate desuccinylase
AHiyo4_34040	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
AHiyo4_34050	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
AHiyo4_34100	ENOG4105W1N	transcriptional regulator
AHiyo4_34110	ENOG4105CMR	udp-glucose 4-epimerase
AHiyo4_34120	ENOG4105CMR	udp-glucose 4-epimerase
AHiyo4_34160	ENOG4108Z4U	Ferredoxin
AHiyo4_34180	ENOG4105CI3	gtp-binding protein typa
AHiyo4_34220	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
AHiyo4_34240	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
AHiyo4_34250	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
AHiyo4_34300	ENOG4105C3G	gtp-binding protein
AHiyo4_34310	ENOG4105C3G	gtp-binding protein
AHiyo4_34330	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
AHiyo4_34350	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
AHiyo4_34360	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
AHiyo4_34370	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
AHiyo4_34380	ENOG4105CSR	polyphosphate kinase 2
AHiyo4_34440	ENOG4107T5X	Binding-protein-dependent transport systems, inner membrane component
AHiyo4_34480	ENOG4105EUB	pirin domain protein
AHiyo4_34490	ENOG4105RD7	BadF BadG BcrA BcrD
AHiyo4_34520	ENOG4105CBN	LysR family transcriptional regulator
AHiyo4_34530	ENOG4105D94	Major Facilitator Superfamily
AHiyo4_34590	ENOG4105D7N	magnesium and cobalt transport protein CorA
AHiyo4_34600	ENOG4105C5H	ABC transporter
AHiyo4_34660	ENOG4105CNN	ABC, transporter
AHiyo4_34670	ENOG4105C2J	ABC transporter
AHiyo4_34680	ENOG41060NJ	transcriptional regulator
AHiyo4_34690	ENOG4107KJX	Transcriptional regulator
AHiyo4_34720	ENOG4107SET	aldo keto reductase
AHiyo4_34780	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
AHiyo4_34820	ENOG4105DKQ	ROK family
AHiyo4_34830	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
AHiyo4_34940	ENOG4105F9F	transposase
AHiyo4_34990	ENOG4105D5G	Transposase
AHiyo4_35000	ENOG4105D5G	Transposase
AHiyo4_35040	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
AHiyo4_35110	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
AHiyo4_35170	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
AHiyo4_35180	ENOG4107QVP	Dehydrogenase
AHiyo4_35210	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
AHiyo4_35220	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
AHiyo4_35240	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
AHiyo4_35260	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
AHiyo4_35320	ENOG4105H3G	oxidoreductase
AHiyo4_35330	ENOG4105WH1	Two component transcriptional regulator luxr family
AHiyo4_35350	ENOG4107RYT	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
AHiyo4_35360	ENOG4107RYT	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
AHiyo4_35370	ENOG4107RYT	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
AHiyo4_35380	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
AHiyo4_35390	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
AHiyo4_35430	ENOG4105F9E	Shikimate 5-dehydrogenase
AHiyo4_35450	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
AHiyo4_35460	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
AHiyo4_35470	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
AHiyo4_35480	ENOG4108R6G	acetyltransferase
AHiyo4_35500	ENOG4108097	ATP-binding protein
AHiyo4_35510	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
AHiyo4_35520	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
AHiyo4_35530	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
AHiyo4_35610	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
AHiyo4_35620	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
AHiyo4_35630	ENOG4105CKU	formyltetrahydrofolate synthetase
AHiyo4_35640	ENOG4105CKU	formyltetrahydrofolate synthetase
AHiyo4_35650	ENOG4105CKU	formyltetrahydrofolate synthetase
AHiyo4_35670	ENOG4105CZA	synthase
AHiyo4_35680	ENOG4105CPC	Aldo Keto reductase
AHiyo4_35790	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
AHiyo4_35800	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
AHiyo4_35820	ENOG41082KK	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
AHiyo4_35870	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
AHiyo4_35880	ENOG4105CS9	pantothenic acid kinase
AHiyo4_35900	ENOG4108UZE	carboxy-peptidase
AHiyo4_35930	ENOG41080FJ	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
AHiyo4_35940	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
AHiyo4_35960	ENOG4105EDW	glycosyl transferase, family 39
AHiyo4_35970	ENOG4108UJD	30S ribosomal protein S9
AHiyo4_35980	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
AHiyo4_36060	ENOG4107QMS	site-determining protein
AHiyo4_36160	ENOG4105EZN	Cobyrinic acid ac-diamide synthase
AHiyo4_36210	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AHiyo4_36230	ENOG4105BZU	Histidine kinase
AHiyo4_36240	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
AHiyo4_36250	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
AHiyo4_36260	ENOG4108ZT0	50S ribosomal protein l17
AHiyo4_36270	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AHiyo4_36280	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
AHiyo4_36290	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AHiyo4_36300	ENOG41067V7	50S ribosomal protein L36
AHiyo4_36310	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
AHiyo4_36320	ENOG4105KXX	peptidase s58 dmpa
AHiyo4_36370	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
AHiyo4_36390	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
AHiyo4_36400	ENOG410849U	50S ribosomal protein L30
AHiyo4_36410	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
AHiyo4_36420	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
AHiyo4_36430	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
AHiyo4_36440	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
AHiyo4_36450	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AHiyo4_36460	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
AHiyo4_36470	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
AHiyo4_36480	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
AHiyo4_36490	ENOG41082SA	50s ribosomal protein l29
AHiyo4_36500	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
AHiyo4_36510	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
AHiyo4_36520	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
AHiyo4_36530	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
AHiyo4_36540	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AHiyo4_36550	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
AHiyo4_36560	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
AHiyo4_36570	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
AHiyo4_36580	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
AHiyo4_36650	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
AHiyo4_36670	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
AHiyo4_36680	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
AHiyo4_36690	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
AHiyo4_36700	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
AHiyo4_36710	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
AHiyo4_36720	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AHiyo4_36730	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AHiyo4_36740	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AHiyo4_36750	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AHiyo4_36770	ENOG4105CHU	acetyl-coa acetyltransferase
AHiyo4_36780	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
AHiyo4_36790	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
AHiyo4_36800	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
AHiyo4_36810	ENOG4108VZM	50s ribosomal protein L10
AHiyo4_36850	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
AHiyo4_36860	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
AHiyo4_36880	ENOG410683Z	Preprotein translocase SecE subunit
AHiyo4_36890	ENOG4105CHM	Aminotransferase
AHiyo4_36920	ENOG4105WH1	Two component transcriptional regulator luxr family
AHiyo4_37070	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
AHiyo4_37100	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
AHiyo4_37150	ENOG4107NHD	transcriptional regulator
AHiyo4_37160	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
AHiyo4_37170	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
AHiyo4_37190	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
AHiyo4_37210	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
AHiyo4_37220	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
AHiyo4_37250	ENOG4107QJH	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
AHiyo4_37300	ENOG4107R4N	Cell wall formation (By similarity)
AHiyo4_37310	ENOG4107R4N	Cell wall formation (By similarity)
AHiyo4_37320	ENOG4106UW1	Major Facilitator superfamily
AHiyo4_37330	ENOG4106UW1	Major Facilitator superfamily
AHiyo4_37350	ENOG410900P	UPF0336 protein
AHiyo4_37390	ENOG4105CHH	sulfate transporter
AHiyo4_37540	ENOG4107QM2	Aldo Keto reductase
AHiyo4_37560	ENOG4105CG3	alpha amylase, catalytic region
AHiyo4_37570	ENOG4105I1K	ABC transporter
AHiyo4_37580	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
AHiyo4_37620	ENOG4105DKQ	ROK family
AHiyo4_37670	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
AHiyo4_37740	ENOG4106032	Glutathionylspermidine synthase
AHiyo4_37780	ENOG4107QPN	acyl-Coa dehydrogenase
AHiyo4_38000	ENOG4105CEY	Amp-dependent synthetase and ligase
AHiyo4_38010	ENOG4105CEY	Amp-dependent synthetase and ligase
AHiyo4_38030	ENOG41080RH	Thioredoxin
AHiyo4_38040	ENOG4105CIG	ABC transporter
AHiyo4_38160	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AHiyo4_38310	ENOG4105VTR	Integrase
AHiyo4_38330	ENOG4108VPT	UPF0234 protein
AHiyo4_38340	ENOG4105D0M	Protease HtpX homolog
AHiyo4_38420	ENOG4105CUB	amino acid
AHiyo4_38430	ENOG4105CUB	amino acid
AHiyo4_38440	ENOG4105EKQ	RNA-directed DNA polymerase
AHiyo4_38470	ENOG4105C26	Dehydrogenase
AHiyo4_38480	ENOG4105C26	Dehydrogenase
AHiyo4_38500	ENOG4107RR1	TRANSCRIPTIONal
AHiyo4_38580	ENOG4105C26	Dehydrogenase
AHiyo4_38590	ENOG4105C26	Dehydrogenase
AHiyo4_38650	ENOG4105JXH	GntR family transcriptional regulator
AHiyo4_38680	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
AHiyo4_38690	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
AHiyo4_38720	ENOG4105C6T	cysteine synthase
AHiyo4_38760	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
AHiyo4_38770	ENOG4108IY8	ABC, transporter
AHiyo4_38790	ENOG4105E0Y	RtcB Protein
AHiyo4_38820	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
AHiyo4_38840	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
AHiyo4_38850	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
AHiyo4_38890	ENOG4105EN6	Membrane
AHiyo4_38970	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
AHiyo4_39000	ENOG4105E4F	Isochorismate synthase
AHiyo4_39010	ENOG4107R0W	ABC transporter
AHiyo4_39040	ENOG4105EAD	ABC transporter
AHiyo4_39050	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
AHiyo4_39070	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
AHiyo4_39080	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
AHiyo4_39090	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
AHiyo4_39100	ENOG4105ETE	Transcriptional regulator (LacI family
AHiyo4_39150	ENOG4105DRS	transport system, permease
AHiyo4_39220	ENOG4107TCW	O-succinylbenzoate synthase
AHiyo4_39310	ENOG4105ETE	Transcriptional regulator (LacI family
AHiyo4_39320	ENOG4105ETE	Transcriptional regulator (LacI family
AHiyo4_39360	ENOG4105DRS	transport system, permease
AHiyo4_39370	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
AHiyo4_39550	ENOG4105CZN	Potassium uptake protein
AHiyo4_39680	ENOG4105BZU	Histidine kinase
AHiyo4_39700	ENOG4106178	UPF0339 protein
AHiyo4_39720	ENOG41061CK	Antibiotic biosynthesis monooxygenase
AHiyo4_39760	ENOG4105BZU	Histidine kinase
AHiyo4_39770	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
AHiyo4_39790	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AHiyo4_39800	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AHiyo4_39820	ENOG4107QJZ	Glycosyl transferase, family 2
AHiyo4_39860	ENOG4107QSN	dihydrolipoamide acetyltransferase
AHiyo4_39890	ENOG4108UW5	maltose o-acetyltransferase
AHiyo4_39940	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
AHiyo4_39950	ENOG4105CPP	Dehydrogenase, E1 component
AHiyo4_39990	ENOG4105EW9	transcriptional regulator AsnC family
AHiyo4_40070	ENOG4105D75	Capsular exopolysaccharide family
AHiyo4_40170	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
AHiyo4_40180	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
AHiyo4_40190	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
AHiyo4_40200	ENOG4105D3Q	Sugar transferase
AHiyo4_40210	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
AHiyo4_40250	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
AHiyo4_40260	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
AHiyo4_40300	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
AHiyo4_40310	ENOG4108ZA2	phenylacetate-CoA oxygenase PaaJ subunit
AHiyo4_40320	ENOG4105D9S	phenylacetate-CoA oxygenase PaaI subunit
AHiyo4_40330	ENOG4105N76	Phenylacetate-CoA oxygenase, subunit
AHiyo4_40340	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
AHiyo4_40400	ENOG4105CEY	Amp-dependent synthetase and ligase
AHiyo4_40410	ENOG4105CEY	Amp-dependent synthetase and ligase
AHiyo4_40480	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
AHiyo4_40500	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
AHiyo4_40510	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
AHiyo4_40520	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
AHiyo4_40570	ENOG4105VG9	Plasmid stabilization system
AHiyo4_40610	ENOG4105C85	amino acid
AHiyo4_40630	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
AHiyo4_40640	ENOG4105EJQ	L-serine dehydratase
AHiyo4_40670	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
AHiyo4_40680	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
AHiyo4_40690	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
AHiyo4_40700	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
AHiyo4_40710	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_40720	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_40730	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_40740	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_40750	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_40850	ENOG4107ZF2	Phosphatase
AHiyo4_40940	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
AHiyo4_40980	ENOG4105C6K	Malic enzyme
AHiyo4_41000	ENOG4108ZJI	phenylacetic acid degradation protein
AHiyo4_41020	ENOG4105DZS	Phenylacetate-CoA ligase
AHiyo4_41030	ENOG4105DZS	Phenylacetate-CoA ligase
AHiyo4_41060	ENOG4105DXM	phenylacetic acid degradation protein
AHiyo4_41070	ENOG4105DXM	phenylacetic acid degradation protein
AHiyo4_41080	ENOG4105KA0	thioesterase Superfamily protein
AHiyo4_41090	ENOG4106T9R	serine protease
AHiyo4_41130	ENOG4108TCJ	secreted hydrolase
AHiyo4_41140	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
AHiyo4_41160	ENOG4105E39	Enoyl-CoA hydratase
AHiyo4_41170	ENOG4105CHU	acetyl-coa acetyltransferase
AHiyo4_41180	ENOG4105CHU	acetyl-coa acetyltransferase
AHiyo4_41240	ENOG4105C85	amino acid
AHiyo4_41260	ENOG4105KH3	nitrite reductase (NAD(P)h) small subunit
AHiyo4_41270	ENOG4108IFG	nitrite reductase, (NAD(P)H)
AHiyo4_41300	ENOG4105CC5	ABC transporter
AHiyo4_41350	ENOG4108TYN	CAAX amino terminal protease family protein
AHiyo4_41360	ENOG4107SIQ	Naphthoate synthase
AHiyo4_41490	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
AHiyo4_41500	ENOG4105CRE	cytochrome C
AHiyo4_41520	ENOG4107QIV	Cytochrome c biogenesis protein
AHiyo4_41550	ENOG4105K63	Thioredoxin
AHiyo4_41560	ENOG4108RH7	phosphoglycerate mutase
AHiyo4_41600	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
AHiyo4_41620	ENOG4108RXW	HAD-superfamily subfamily IB hydrolase
AHiyo4_41640	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
AHiyo4_41660	ENOG4105I82	acetyl xylan esterase
AHiyo4_41910	ENOG41060NJ	transcriptional regulator
AHiyo4_41930	ENOG4105FDP	GntR family transcriptional regulator
AHiyo4_42000	ENOG41082BM	Transcriptional regulator, arsr family
AHiyo4_42030	ENOG4105DGU	Histone deacetylase
AHiyo4_42040	ENOG4105CZN	Potassium uptake protein
AHiyo4_42060	ENOG4105II7	pyrroline-5-carboxylate reductase
AHiyo4_42070	ENOG4107R33	ppx gppa phosphatase
AHiyo4_42080	ENOG4107R33	ppx gppa phosphatase
AHiyo4_42110	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
AHiyo4_42120	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
AHiyo4_42130	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
AHiyo4_42140	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
AHiyo4_42150	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
AHiyo4_42180	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
AHiyo4_42220	ENOG4105C72	UPF0176 protein
AHiyo4_42250	ENOG4108I5C	dEAD DEAH box helicase
AHiyo4_42410	ENOG4105P8F	nudix hydrolase
AHiyo4_42460	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
AHiyo4_42470	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
AHiyo4_42510	ENOG4105I1K	ABC transporter
AHiyo4_42520	ENOG4105MVE	transcriptional regulator
AHiyo4_42540	ENOG4105ETE	Transcriptional regulator (LacI family
AHiyo4_42570	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
AHiyo4_42630	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
AHiyo4_42710	ENOG4105BZ4	penicillin-binding protein
AHiyo4_42750	ENOG4105BZ1	(ABC) transporter
AHiyo4_42760	ENOG4105BZ1	(ABC) transporter
AHiyo4_42770	ENOG4105BZ1	(ABC) transporter
AHiyo4_42840	ENOG4105C8V	SAICAR synthetase
AHiyo4_42850	ENOG4105C8V	SAICAR synthetase
AHiyo4_42860	ENOG4105C12	Phosphoribosylglycinamide synthetase
AHiyo4_42870	ENOG4105C12	Phosphoribosylglycinamide synthetase
AHiyo4_42940	ENOG4105BZP	glycoside hydrolase 15-related
AHiyo4_42950	ENOG4105BZP	glycoside hydrolase 15-related
AHiyo4_42960	ENOG4105BZP	glycoside hydrolase 15-related
AHiyo4_42990	ENOG4105CS2	ec 3.2.1.21
AHiyo4_43030	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
AHiyo4_43040	ENOG41087EV	Hsp20/alpha crystallin family
AHiyo4_43090	ENOG4105F1N	DNA alkylation repair
AHiyo4_43130	ENOG4105CHR	reductase
AHiyo4_43240	ENOG4105E9Z	Nad-dependent epimerase dehydratase
AHiyo4_43250	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
AHiyo4_43280	ENOG4108KXV	response regulator
AHiyo4_43400	ENOG4108M8W	Monooxygenase
AHiyo4_43430	ENOG4105JP4	Inner membrane protein yidG
AHiyo4_43560	ENOG4105BZ4	penicillin-binding protein
AHiyo4_43600	ENOG4105CH2	amidohydrolase
AHiyo4_43610	ENOG4105CH2	amidohydrolase
AHiyo4_43750	ENOG4107TE5	Lipid kinase
AHiyo4_43760	ENOG4105S7S	phosphonate abc transporter
AHiyo4_43810	ENOG4105DJB	Major Facilitator Superfamily
AHiyo4_43820	ENOG4105DRR	Transcriptional regulator, GntR family
AHiyo4_43870	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
AHiyo4_43880	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
AHiyo4_43890	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
AHiyo4_43940	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
AHiyo4_43950	ENOG4105C7W	Xanthine dehydrogenase
AHiyo4_43970	ENOG4105C7W	Xanthine dehydrogenase
AHiyo4_43980	ENOG4105C7W	Xanthine dehydrogenase
AHiyo4_43990	ENOG4108UTP	(2Fe-2S)-binding domain protein
AHiyo4_44020	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
AHiyo4_44030	ENOG4105C7N	Xanthine uracil vitamin C permease
AHiyo4_44040	ENOG4105C7N	Xanthine uracil vitamin C permease
AHiyo4_44050	ENOG4107Y2X	deaminase
AHiyo4_44060	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
AHiyo4_44100	ENOG4105C2W	permease
AHiyo4_44110	ENOG41069M3	Transcriptional regulator
AHiyo4_44130	ENOG4107R9S	Malate synthase
AHiyo4_44150	ENOG4105S0E	allantoin catabolism protein
AHiyo4_44170	ENOG41088SP	formiminoglutamate hydrolase
AHiyo4_44190	ENOG4105CV8	reductase
AHiyo4_44200	ENOG4105CV8	reductase
AHiyo4_44220	ENOG4108UHE	carbonic anhydrase
AHiyo4_44300	ENOG4107TFQ	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
AHiyo4_44310	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
AHiyo4_44320	ENOG41060W2	glyoxylate carboligase
AHiyo4_44330	ENOG41060W2	glyoxylate carboligase
AHiyo4_44340	ENOG41060W2	glyoxylate carboligase
AHiyo4_44350	ENOG4105BZW	Glycerate kinase
AHiyo4_44360	ENOG4107QP3	malate synthase g
AHiyo4_44390	ENOG4105DAA	L-lactate
AHiyo4_44400	ENOG4105CQB	FAD linked oxidase domain protein
AHiyo4_44410	ENOG4105CQB	FAD linked oxidase domain protein
AHiyo4_44420	ENOG4105FDP	GntR family transcriptional regulator
AHiyo4_44470	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
AHiyo4_44510	ENOG4105CPQ	Dehydrogenase
AHiyo4_44620	ENOG4105CEI	nitrite reductase
AHiyo4_44700	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
AHiyo4_44780	ENOG4105CDA	abc transporter atp-binding protein
AHiyo4_44800	ENOG4105FDP	GntR family transcriptional regulator
AHiyo4_44810	ENOG4105C2J	ABC transporter
AHiyo4_44820	ENOG4105CNN	ABC, transporter
AHiyo4_44850	ENOG4107KJX	Transcriptional regulator
AHiyo4_44870	ENOG4106A3M	Cytochrome p-450
AHiyo4_44950	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
AHiyo4_45020	ENOG4105DAX	Pfam:DUF2983
AHiyo4_45160	ENOG4105CUB	amino acid
AHiyo4_45200	ENOG4108Z86	Glutamine amidotransferase
AHiyo4_45220	ENOG4105C26	Dehydrogenase
AHiyo4_45230	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
AHiyo4_45260	ENOG4105CFM	UPF0317 protein
AHiyo4_45300	ENOG4108KXV	response regulator
AHiyo4_45370	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
AHiyo4_45380	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
AHiyo4_45400	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
AHiyo4_45410	ENOG4105CHU	acetyl-coa acetyltransferase
AHiyo4_45420	ENOG4105CHU	acetyl-coa acetyltransferase
AHiyo4_45430	ENOG4105CHU	acetyl-coa acetyltransferase
AHiyo4_45450	ENOG4105C1G	acyl-Coa dehydrogenase
AHiyo4_45510	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
AHiyo4_45520	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
AHiyo4_45530	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
AHiyo4_45540	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
AHiyo4_45550	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
AHiyo4_45570	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
AHiyo4_45600	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
AHiyo4_45660	ENOG4107TYC	hydantoinase B oxoprolinase
AHiyo4_45690	ENOG4108UAU	isochorismatase
AHiyo4_45780	ENOG4108JJB	ABC transporter
AHiyo4_45790	ENOG4107R6F	Alpha Beta Hydrolase Fold protein
AHiyo4_45820	ENOG4105C3R	Methionine synthase
AHiyo4_45830	ENOG4105C3R	Methionine synthase
AHiyo4_45840	ENOG4105C3R	Methionine synthase
AHiyo4_45990	ENOG4105K63	Thioredoxin
AHiyo4_46070	ENOG4105D13	transposase
AHiyo4_46080	ENOG4105BZU	Histidine kinase
AHiyo4_46210	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
AHiyo4_46220	ENOG4107USC	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
AHiyo4_46230	ENOG4107USC	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
AHiyo4_46350	ENOG4105K6V	RNA polymerase
AHiyo4_46400	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
AHiyo4_46460	ENOG4105CSV	Glutaminase
AHiyo4_46490	ENOG41082JN	Transcriptional regulator
AHiyo4_46670	ENOG4105CHM	Aminotransferase
AHiyo4_46680	ENOG4105CI2	imidazolone-5-propionate hydrolase
AHiyo4_46720	ENOG4108IJ8	ABC transporter
AHiyo4_46740	ENOG4105E90	ABC transporter
AHiyo4_46760	ENOG4105CGP	Urocanate hydratase
AHiyo4_46780	ENOG4105C84	Histidine ammonia-lyase
AHiyo4_46850	ENOG4105N14	lysine exporter protein LysE YggA
AHiyo4_46920	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AHiyo4_46930	ENOG4107QZ7	Cellulose synthase catalytic subunit
AHiyo4_46950	ENOG4105WN5	stage II sporulation protein
AHiyo4_46990	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
AHiyo4_47090	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
AHiyo4_47120	ENOG4105E2Y	ABC, transporter
AHiyo4_47180	ENOG4105X1Q	TOBE domain protein
AHiyo4_47250	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
AHiyo4_47280	ENOG4107YEV	ferritin
AHiyo4_47320	ENOG4105DBI	uridine monophosphokinase
AHiyo4_47350	ENOG4105C1J	atp-dependent rna helicase
AHiyo4_47360	ENOG4105C1J	atp-dependent rna helicase
AHiyo4_47410	ENOG4105DJ2	Major Facilitator Superfamily
AHiyo4_47430	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
AHiyo4_47580	ENOG4107R3N	Filamentation induced by cAMP protein fic
AHiyo4_47600	ENOG4105C0D	helicase
AHiyo4_47680	ENOG4107R37	Glutamate dehydrogenase
AHiyo4_47700	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
AHiyo4_47740	ENOG4105C5Y	PTS System
AHiyo4_47750	ENOG4105FDP	GntR family transcriptional regulator
AHiyo4_47770	ENOG4105QPS	Monooxygenase
AHiyo4_47790	ENOG4108IV0	ABC, transporter
AHiyo4_47800	ENOG4108IUZ	ABC transporter
AHiyo4_47810	ENOG4105C0Z	ABC transporter
AHiyo4_47820	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
AHiyo4_47830	ENOG4105C32	Amino acid ABC transporter (Permease)
AHiyo4_47850	ENOG4105KNI	merR family transcriptional Regulator
AHiyo4_47860	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
AHiyo4_47870	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AHiyo4_47890	ENOG4105CFG	Acts as a chaperone (By similarity)
AHiyo4_48050	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
AHiyo4_48100	ENOG4105CHU	acetyl-coa acetyltransferase
AHiyo4_48110	ENOG4105CHU	acetyl-coa acetyltransferase
AHiyo4_48220	ENOG4106PVI	ATP-dependent carboxylate-amine ligase (By similarity)
AHiyo4_48230	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
AHiyo4_48260	ENOG4108JJB	ABC transporter
AHiyo4_48270	ENOG4105NSK	ABC superfamily ATP binding cassette transporter membrane protein
AHiyo4_48280	ENOG41090KN	UPF0303 protein
AHiyo4_48290	ENOG4105KJM	monovalent cation h antiporter subunit g
AHiyo4_48300	ENOG41080TA	Multiple resistance and ph regulation protein f
AHiyo4_48320	ENOG4108JPZ	Monovalent cation H antiporter subunit D
AHiyo4_48330	ENOG4105MKQ	Monovalent cation H antiporter subunit C
AHiyo4_48340	ENOG4105D65	subunit l
AHiyo4_48350	ENOG4105D65	subunit l
AHiyo4_48380	ENOG4105D0C	transport protein
AHiyo4_48390	ENOG4107S91	Sodium hydrogen exchanger
AHiyo4_48410	ENOG4105DHP	deoxycytidine triphosphate deaminase
AHiyo4_48480	ENOG4106NZI	LysR family Transcriptional regulator
AHiyo4_48510	ENOG4105C26	Dehydrogenase
AHiyo4_48530	ENOG4105CUB	amino acid
AHiyo4_48540	ENOG4105CUB	amino acid
AHiyo4_48550	ENOG4105CUB	amino acid
AHiyo4_48560	ENOG4107RSM	transcriptional regulator
AHiyo4_48570	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
AHiyo4_48610	ENOG4105BZP	glycoside hydrolase 15-related
AHiyo4_48660	ENOG4105CKB	glycosidase
AHiyo4_48720	ENOG4105BZ7	extracellular solute-binding protein family 1
AHiyo4_48730	ENOG4105ETE	Transcriptional regulator (LacI family
AHiyo4_48740	ENOG4105DEN	Luciferase family
AHiyo4_48780	ENOG4105C26	Dehydrogenase
AHiyo4_48790	ENOG4105C26	Dehydrogenase
AHiyo4_48840	ENOG4105D7A	ATP-binding protein
AHiyo4_48850	ENOG4105D7A	ATP-binding protein
AHiyo4_48930	ENOG4108426	dNA-binding protein
AHiyo4_48980	ENOG41080FR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
AHiyo4_48990	ENOG4105W0E	50S ribosomal protein L33
AHiyo4_49000	ENOG4105KDC	50s ribosomal protein l28
AHiyo4_49040	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
AHiyo4_49110	ENOG4105E0A	ABC, transporter
AHiyo4_49120	ENOG4108IHU	transport system permease protein
AHiyo4_49130	ENOG4108IHU	transport system permease protein
AHiyo4_49140	ENOG4105DQ5	transport system permease protein
AHiyo4_49150	ENOG4105DQ5	transport system permease protein
AHiyo4_49330	ENOG4108FN7	Aldo keto reductase
AHiyo4_49340	ENOG4105CPC	Aldo Keto reductase
AHiyo4_49350	ENOG4107YVI	ribose 5-phosphate isomerase
AHiyo4_49370	ENOG4105CMT	Dihydroxyacetone kinase
AHiyo4_49400	ENOG4105D1E	Undecaprenyl pyrophosphate phosphatase
AHiyo4_49410	ENOG4105DQR	SNARE associated Golgi
AHiyo4_49420	ENOG4105ETX	regulatoR
AHiyo4_49440	ENOG4105GR3	Histidine kinase
AHiyo4_49450	ENOG4105EB3	Histidine kinase
AHiyo4_49530	ENOG4105BZP	glycoside hydrolase 15-related
AHiyo4_49540	ENOG4105JXH	GntR family transcriptional regulator
AHiyo4_49560	ENOG4108IJ0	Aspartate ammonia-lyase
AHiyo4_49570	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
AHiyo4_49590	ENOG4105BZU	Histidine kinase
AHiyo4_49600	ENOG4105BZU	Histidine kinase
AHiyo4_49640	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
AHiyo4_49650	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
AHiyo4_49720	ENOG4108XM1	transcriptional regulator AsnC family
AHiyo4_49730	ENOG4105N14	lysine exporter protein LysE YggA
AHiyo4_49770	ENOG4105C6K	Malic enzyme
AHiyo4_49780	ENOG4108SGK	Tetr family transcriptional regulator
AHiyo4_49820	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
AHiyo4_49880	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
AHiyo4_49890	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
AHiyo4_49900	ENOG4105CTS	PTS system mannitol-specific
AHiyo4_49920	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
AHiyo4_49930	ENOG4105KRI	phosphocarrier protein (HPr
AHiyo4_49970	ENOG4105DCF	alanine dehydrogenase
AHiyo4_49980	ENOG4105DCF	alanine dehydrogenase
AHiyo4_49990	ENOG4105DCF	alanine dehydrogenase
AHiyo4_50020	ENOG4105D9R	oxidoreductase
AHiyo4_50050	ENOG4108JQ7	(ABC) transporter
AHiyo4_50110	ENOG4108JGH	Tetr family transcriptional regulator
AHiyo4_50120	ENOG4108YYH	Nadph-dependent fmn reductase
AHiyo4_50150	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
AHiyo4_50200	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
AHiyo4_50210	ENOG4105CPP	Dehydrogenase, E1 component
AHiyo4_50230	ENOG4105CIH	Imidazole acetol-phosphate transaminase
AHiyo4_50250	ENOG41082T9	Membrane
AHiyo4_50280	ENOG4107QTF	adenylosuccinate lyase
AHiyo4_50290	ENOG4105GCF	PGAM
AHiyo4_50300	ENOG4105C7I	Dehydrogenase
AHiyo4_50320	ENOG4105NAU	thioesterase Superfamily protein
AHiyo4_50330	ENOG4107104	thymidine kinase
AHiyo4_50340	ENOG4107104	thymidine kinase
AHiyo4_50360	ENOG4107TE5	Lipid kinase
AHiyo4_50370	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
AHiyo4_50380	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
AHiyo4_50390	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
AHiyo4_50400	ENOG4105W8H	transhydrogenase (subunit alpha
AHiyo4_50410	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
AHiyo4_50420	ENOG4107HP6	Transcriptional regulator
AHiyo4_50430	ENOG4105E2X	shikimate dehydrogenase
AHiyo4_50440	ENOG4105CSH	Transporter
AHiyo4_50450	ENOG4107HP6	Transcriptional regulator
AHiyo4_50460	ENOG4107QNJ	CoA-transferase subunit B
AHiyo4_50470	ENOG4107QP7	CoA-transferase subunit A
AHiyo4_50490	ENOG4105CHU	acetyl-coa acetyltransferase
AHiyo4_50500	ENOG4105CHU	acetyl-coa acetyltransferase
AHiyo4_50510	ENOG4108UWZ	4-Carboxymuconolactone decarboxylase
AHiyo4_50540	ENOG4107RAW	3-carboxy-cis-cis-muconate cycloisomerase
AHiyo4_50550	ENOG4105RM9	Protocatechuate 3,4-dioxygenase alpha
AHiyo4_50600	ENOG4107S9B	Shikimate dehydrogenase
AHiyo4_50610	ENOG4105J4Q	Transcriptional regulator
AHiyo4_50740	ENOG4105VPX	protein, conserved in bacteria
AHiyo4_50860	ENOG4107QI1	Mate efflux family protein
AHiyo4_50900	ENOG4105CDU	Replicative dna helicase
AHiyo4_50910	ENOG4105CDU	Replicative dna helicase
AHiyo4_50960	ENOG4108UZX	fmn reductase
AHiyo4_51110	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
AHiyo4_51120	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
AHiyo4_51140	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
AHiyo4_51160	ENOG4105WH1	Two component transcriptional regulator luxr family
AHiyo4_51170	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase