locus-tag	class	description
AHiyo4_00010	COG0463	Glycosyl transferase, family 2
AHiyo4_00020	COG1362	aminopeptidase activity
AHiyo4_00030	COG1362	aminopeptidase activity
AHiyo4_00050	COG2197	response regulator
AHiyo4_00110	COG0738	Major facilitator superfamily
AHiyo4_00120	COG2223	nitrite transmembrane transporter activity
AHiyo4_00140	COG0488	(ABC) transporter
AHiyo4_00180	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AHiyo4_00220	COG0406	alpha-ribazole phosphatase activity
AHiyo4_00240	COG0617	tRNA 3'-terminal CCA addition
AHiyo4_00300	COG0492	ferredoxin-NADP+ reductase activity
AHiyo4_00310	COG3118	belongs to the thioredoxin family
AHiyo4_00350	COG1192	Involved in chromosome partitioning
AHiyo4_00370	COG0357	Ribosomal RNA small subunit methyltransferase G
AHiyo4_00400	COG0706	membrane insertase activity
AHiyo4_00410	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AHiyo4_00420	COG0594	ribonuclease P activity
AHiyo4_00430	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AHiyo4_00440	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AHiyo4_00450	COG0592	DNA-directed DNA polymerase activity
AHiyo4_00460	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AHiyo4_00470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AHiyo4_00480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AHiyo4_00490	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AHiyo4_00500	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AHiyo4_00510	COG0187	DNA topoisomerase II activity
AHiyo4_00520	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AHiyo4_00530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AHiyo4_00540	COG3266	domain, Protein
AHiyo4_00580	COG1215	transferase activity, transferring glycosyl groups
AHiyo4_00620	COG0705	Rhomboid family
AHiyo4_00630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AHiyo4_00640	COG2818	Glycosylase
AHiyo4_00660	COG3764	Sortase (surface protein transpeptidase)
AHiyo4_00690	COG0515	serine threonine protein kinase
AHiyo4_00700	COG0515	serine threonine protein kinase
AHiyo4_00710	COG0515	serine threonine protein kinase
AHiyo4_00730	COG0768	penicillin binding
AHiyo4_00750	COG0772	Belongs to the SEDS family
AHiyo4_00770	COG1716	ATPase activity
AHiyo4_00780	COG1716	ATPase activity
AHiyo4_00910	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AHiyo4_00990	COG1309	transcriptional regulator
AHiyo4_01030	COG1176	ABC-type spermidine putrescine transport system, permease component I
AHiyo4_01050	COG1176	ABC-type spermidine putrescine transport system, permease component I
AHiyo4_01060	COG3842	ATPase activity
AHiyo4_01130	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo4_01140	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo4_01150	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo4_01160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AHiyo4_01240	COG2186	Transcriptional regulator
AHiyo4_01250	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AHiyo4_01260	COG0477	Major facilitator Superfamily
AHiyo4_01270	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AHiyo4_01280	COG1984	allophanate hydrolase subunit 2
AHiyo4_01290	COG0439	Biotin carboxylase
AHiyo4_01300	COG4770	biotin carboxylase activity
AHiyo4_01330	COG0831	urea catabolic process
AHiyo4_01340	COG0832	Belongs to the urease beta subunit family
AHiyo4_01360	COG0804	urea catabolic process
AHiyo4_01370	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AHiyo4_01380	COG0830	nickel cation binding
AHiyo4_01400	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AHiyo4_01410	COG0829	nickel cation binding
AHiyo4_01420	COG0829	nickel cation binding
AHiyo4_01430	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AHiyo4_01450	COG2814	Major facilitator Superfamily
AHiyo4_01460	COG2026	Addiction module toxin, RelE StbE family
AHiyo4_01470	COG2161	toxin-antitoxin pair type II binding
AHiyo4_01500	COG1136	(ABC) transporter
AHiyo4_01530	COG2197	response regulator
AHiyo4_01540	COG3706	GGDEF domain
AHiyo4_01550	COG0659	secondary active sulfate transmembrane transporter activity
AHiyo4_01630	COG1609	Transcriptional regulator
AHiyo4_01670	COG5001	Diguanylate cyclase
AHiyo4_01670	COG3300	MHYT domain
AHiyo4_01750	COG0252	asparaginase activity
AHiyo4_01770	COG0726	polysaccharide deacetylase
AHiyo4_01780	COG0726	polysaccharide deacetylase
AHiyo4_01790	COG1609	Transcriptional regulator
AHiyo4_01800	COG1609	Transcriptional regulator
AHiyo4_01820	COG0523	cobalamin synthesis protein
AHiyo4_01890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AHiyo4_01940	COG0583	DNA-binding transcription factor activity
AHiyo4_01970	COG0302	gtp cyclohydrolase
AHiyo4_01980	COG0302	gtp cyclohydrolase
AHiyo4_02020	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AHiyo4_02040	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AHiyo4_02050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AHiyo4_02140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AHiyo4_02150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AHiyo4_02200	COG1760	l-serine dehydratase
AHiyo4_02210	COG1760	l-serine dehydratase
AHiyo4_02340	COG1113	amino acid transport
AHiyo4_02350	COG1113	amino acid transport
AHiyo4_02400	COG2226	methyltransferase
AHiyo4_02420	COG0640	Transcriptional regulator
AHiyo4_02430	COG0477	Major facilitator Superfamily
AHiyo4_02440	COG0477	Major facilitator Superfamily
AHiyo4_02450	COG0640	Transcriptional regulator
AHiyo4_02500	COG0584	glycerophosphoryl diester phosphodiesterase
AHiyo4_02510	COG2200	EAL domain
AHiyo4_02540	COG0784	Response regulator, receiver
AHiyo4_02540	COG5002	protein histidine kinase activity
AHiyo4_02540	COG2205	protein histidine kinase activity
AHiyo4_02580	COG1929	Belongs to the glycerate kinase type-1 family
AHiyo4_02640	COG2755	lipolytic protein G-D-S-L family
AHiyo4_02650	COG2233	PERMEase
AHiyo4_02660	COG2233	PERMEase
AHiyo4_02670	COG0778	Nitroreductase
AHiyo4_02680	COG0033	Phosphoglucomutase
AHiyo4_02770	COG0154	amidase activity
AHiyo4_02780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AHiyo4_02780	COG0425	Belongs to the sulfur carrier protein TusA family
AHiyo4_02810	COG1597	lipid kinase activity
AHiyo4_02820	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AHiyo4_02840	COG0561	phosphatase activity
AHiyo4_02850	COG0561	phosphatase activity
AHiyo4_02880	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AHiyo4_02910	COG2272	Belongs to the type-B carboxylesterase lipase family
AHiyo4_02980	COG0037	tRNA processing
AHiyo4_03010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AHiyo4_03020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AHiyo4_03030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AHiyo4_03040	COG0302	gtp cyclohydrolase
AHiyo4_03050	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AHiyo4_03060	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AHiyo4_03120	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AHiyo4_03130	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AHiyo4_03210	COG1309	transcriptional regulator
AHiyo4_03250	COG2814	Major facilitator Superfamily
AHiyo4_03300	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AHiyo4_03330	COG0542	response to heat
AHiyo4_03360	COG0542	response to heat
AHiyo4_03370	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AHiyo4_03380	COG2376	Dihydroxyacetone kinase
AHiyo4_03390	COG2376	Dihydroxyacetone kinase
AHiyo4_03400	COG1461	Dihydroxyacetone kinase
AHiyo4_03430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AHiyo4_03430	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AHiyo4_03430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AHiyo4_03500	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AHiyo4_03510	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AHiyo4_03520	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AHiyo4_03580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AHiyo4_03590	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AHiyo4_03620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AHiyo4_03630	COG0306	phosphate transporter
AHiyo4_03790	COG2890	protein-(glutamine-N5) methyltransferase activity
AHiyo4_03850	COG2261	transglycosylase associated protein
AHiyo4_03860	COG0656	L-ascorbic acid biosynthetic process
AHiyo4_03900	COG0667	Aldo Keto reductase
AHiyo4_03910	COG0667	Aldo Keto reductase
AHiyo4_03920	COG0656	L-ascorbic acid biosynthetic process
AHiyo4_03930	COG3360	Dodecin
AHiyo4_03940	COG2186	Transcriptional regulator
AHiyo4_03950	COG2084	Dehydrogenase
AHiyo4_03990	COG0076	glutamate decarboxylase activity
AHiyo4_04000	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AHiyo4_04080	COG0300	oxidoreductase activity
AHiyo4_04110	COG0477	Major facilitator Superfamily
AHiyo4_04150	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AHiyo4_04220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AHiyo4_04220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AHiyo4_04230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AHiyo4_04230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AHiyo4_04230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AHiyo4_04240	COG1105	Belongs to the carbohydrate kinase PfkB family
AHiyo4_04250	COG1349	DNA-binding transcription factor activity
AHiyo4_04330	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AHiyo4_04340	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AHiyo4_04350	COG2733	membrane
AHiyo4_04540	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo4_04570	COG1733	regulation of RNA biosynthetic process
AHiyo4_04590	COG0702	epimerase
AHiyo4_04600	COG1280	lysine exporter protein (LysE YggA)
AHiyo4_04630	COG1476	TRANSCRIPTIONal
AHiyo4_04710	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AHiyo4_04720	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AHiyo4_04740	COG2986	histidine ammonia-lyase
AHiyo4_04750	COG2986	histidine ammonia-lyase
AHiyo4_04780	COG0589	response to stress
AHiyo4_04840	COG3290	protein histidine kinase activity
AHiyo4_04850	COG4565	transcriptional regulatory protein
AHiyo4_04860	COG2252	PERMEase
AHiyo4_04870	COG2252	PERMEase
AHiyo4_04890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AHiyo4_04940	COG3848	Pyruvate phosphate dikinase
AHiyo4_04940	COG0574	Belongs to the PEP-utilizing enzyme family
AHiyo4_04950	COG3848	Pyruvate phosphate dikinase
AHiyo4_04950	COG0574	Belongs to the PEP-utilizing enzyme family
AHiyo4_04960	COG0574	Belongs to the PEP-utilizing enzyme family
AHiyo4_04960	COG3848	Pyruvate phosphate dikinase
AHiyo4_05020	COG0791	NLP P60 protein
AHiyo4_05020	COG3883	PFAM NLP P60 protein
AHiyo4_05090	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AHiyo4_05090	COG1796	DNA polymerase
AHiyo4_05110	COG1621	beta-fructofuranosidase activity
AHiyo4_05190	COG1653	transport
AHiyo4_05200	COG1653	transport
AHiyo4_05210	COG1175	transmembrane transport
AHiyo4_05220	COG0395	ABC-type sugar transport system, permease component
AHiyo4_05230	COG1609	Transcriptional regulator
AHiyo4_05310	COG1024	Enoyl-CoA hydratase
AHiyo4_05330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AHiyo4_05340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AHiyo4_05350	COG1960	acyl-CoA dehydrogenase activity
AHiyo4_05360	COG1278	Cold shock
AHiyo4_05370	COG2197	response regulator
AHiyo4_05400	COG0666	response to abiotic stimulus
AHiyo4_05410	COG0438	transferase activity, transferring glycosyl groups
AHiyo4_05490	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AHiyo4_05530	COG1609	Transcriptional regulator
AHiyo4_05630	COG4608	Belongs to the ABC transporter superfamily
AHiyo4_05660	COG0673	inositol 2-dehydrogenase activity
AHiyo4_05680	COG1609	Transcriptional regulator
AHiyo4_05690	COG1904	glucuronate isomerase
AHiyo4_05700	COG0246	Mannitol dehydrogenase
AHiyo4_05720	COG4948	Mandelate Racemase Muconate Lactonizing
AHiyo4_05750	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AHiyo4_05840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AHiyo4_05850	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AHiyo4_05880	COG1832	CoA-binding protein
AHiyo4_05920	COG2315	Protein conserved in bacteria
AHiyo4_05960	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AHiyo4_05970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AHiyo4_05980	COG0047	phosphoribosylformylglycinamidine synthase activity
AHiyo4_06090	COG1846	Transcriptional regulator
AHiyo4_06130	COG1131	(ABC) transporter
AHiyo4_06160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AHiyo4_06200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AHiyo4_06240	COG0739	heme binding
AHiyo4_06240	COG0741	lytic transglycosylase activity
AHiyo4_06240	COG1196	nuclear chromosome segregation
AHiyo4_06250	COG0386	Belongs to the glutathione peroxidase family
AHiyo4_06270	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AHiyo4_06340	COG1309	transcriptional regulator
AHiyo4_06410	COG0673	inositol 2-dehydrogenase activity
AHiyo4_06450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AHiyo4_06460	COG2807	transmembrane transport
AHiyo4_06540	COG2205	protein histidine kinase activity
AHiyo4_06560	COG0343	queuine tRNA-ribosyltransferase activity
AHiyo4_06570	COG0343	queuine tRNA-ribosyltransferase activity
AHiyo4_06660	COG3842	ATPase activity
AHiyo4_06720	COG1960	acyl-CoA dehydrogenase activity
AHiyo4_06750	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AHiyo4_06760	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AHiyo4_06770	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AHiyo4_06870	COG0564	pseudouridine synthase activity
AHiyo4_06900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AHiyo4_06920	COG2364	Membrane
AHiyo4_06960	COG1201	RNA secondary structure unwinding
AHiyo4_06970	COG1201	RNA secondary structure unwinding
AHiyo4_07020	COG1609	Transcriptional regulator
AHiyo4_07030	COG4209	transmembrane transport
AHiyo4_07040	COG0395	ABC-type sugar transport system, permease component
AHiyo4_07050	COG1653	transport
AHiyo4_07070	COG1621	beta-fructofuranosidase activity
AHiyo4_07140	COG2070	2-Nitropropane dioxygenase
AHiyo4_07240	COG0590	tRNA wobble adenosine to inosine editing
AHiyo4_07250	COG0671	phosphoesterase, PA-phosphatase related
AHiyo4_07260	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AHiyo4_07300	COG2205	protein histidine kinase activity
AHiyo4_07310	COG0745	RESPONSE REGULATOR receiver
AHiyo4_07350	COG0697	spore germination
AHiyo4_07370	COG1309	transcriptional regulator
AHiyo4_07380	COG1511	domain protein
AHiyo4_07420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AHiyo4_07440	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AHiyo4_07450	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AHiyo4_07460	COG1017	nitric oxide dioxygenase activity
AHiyo4_07460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AHiyo4_07490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AHiyo4_07520	COG0514	ATP-dependent DNA helicase (RecQ)
AHiyo4_07560	COG1505	serine-type exopeptidase activity
AHiyo4_07580	COG1505	serine-type exopeptidase activity
AHiyo4_07620	COG0582	viral genome integration into host DNA
AHiyo4_07770	COG0604	alcohol dehydrogenase
AHiyo4_07790	COG0577	efflux transmembrane transporter activity
AHiyo4_07790	COG1136	(ABC) transporter
AHiyo4_07810	COG1966	Carbon starvation protein
AHiyo4_07940	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AHiyo4_07950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AHiyo4_07960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AHiyo4_08010	COG0588	phosphoglycerate mutase activity
AHiyo4_08030	COG5002	protein histidine kinase activity
AHiyo4_08080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AHiyo4_08090	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AHiyo4_08110	COG0215	cysteine-tRNA ligase activity
AHiyo4_08210	COG0366	Alpha amylase catalytic
AHiyo4_08230	COG0366	Alpha amylase catalytic
AHiyo4_08260	COG3281	Trehalose synthase
AHiyo4_08270	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AHiyo4_08310	COG0366	Alpha amylase catalytic
AHiyo4_08340	COG0277	FAD linked oxidase domain protein
AHiyo4_08350	COG0277	FAD linked oxidase domain protein
AHiyo4_08370	COG3842	ATPase activity
AHiyo4_08390	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AHiyo4_08470	COG2957	Belongs to the agmatine deiminase family
AHiyo4_08480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AHiyo4_08490	COG0783	Belongs to the Dps family
AHiyo4_08500	COG0477	Major facilitator Superfamily
AHiyo4_08520	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_08520	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_08530	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_08530	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_08650	COG1278	Cold shock
AHiyo4_08670	COG0459	protein refolding
AHiyo4_08710	COG2205	protein histidine kinase activity
AHiyo4_08730	COG0745	RESPONSE REGULATOR receiver
AHiyo4_08790	COG1278	Cold shock
AHiyo4_08840	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AHiyo4_08870	COG0739	heme binding
AHiyo4_08960	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AHiyo4_08970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AHiyo4_09040	COG0488	(ABC) transporter
AHiyo4_09050	COG1132	(ABC) transporter
AHiyo4_09060	COG1132	(ABC) transporter
AHiyo4_09070	COG1132	(ABC) transporter
AHiyo4_09080	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AHiyo4_09150	COG0483	inositol monophosphate 1-phosphatase activity
AHiyo4_09220	COG0045	succinate-CoA ligase (ADP-forming) activity
AHiyo4_09270	COG0640	Transcriptional regulator
AHiyo4_09280	COG1942	4-Oxalocrotonate Tautomerase
AHiyo4_09290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AHiyo4_09320	COG3962	Belongs to the TPP enzyme family
AHiyo4_09370	COG0673	inositol 2-dehydrogenase activity
AHiyo4_09380	COG1082	Xylose isomerase domain protein TIM barrel
AHiyo4_09420	COG0673	inositol 2-dehydrogenase activity
AHiyo4_09430	COG1609	Transcriptional regulator
AHiyo4_09480	COG0673	inositol 2-dehydrogenase activity
AHiyo4_09490	COG0673	inositol 2-dehydrogenase activity
AHiyo4_09500	COG0673	inositol 2-dehydrogenase activity
AHiyo4_09520	COG0673	inositol 2-dehydrogenase activity
AHiyo4_09540	COG0673	inositol 2-dehydrogenase activity
AHiyo4_09550	COG1609	Transcriptional regulator
AHiyo4_09570	COG3718	enzyme involved in inositol metabolism
AHiyo4_09590	COG2186	Transcriptional regulator
AHiyo4_09600	COG2814	Major facilitator Superfamily
AHiyo4_09680	COG1396	sequence-specific DNA binding
AHiyo4_09730	COG0028	Belongs to the TPP enzyme family
AHiyo4_09860	COG1401	restriction endodeoxyribonuclease activity
AHiyo4_09870	COG1401	restriction endodeoxyribonuclease activity
AHiyo4_09910	COG5002	protein histidine kinase activity
AHiyo4_09920	COG0745	RESPONSE REGULATOR receiver
AHiyo4_09980	COG1902	pentaerythritol trinitrate reductase activity
AHiyo4_10020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AHiyo4_10060	COG1652	LysM domain
AHiyo4_10070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AHiyo4_10120	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AHiyo4_10130	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AHiyo4_10180	COG1254	Belongs to the acylphosphatase family
AHiyo4_10190	COG2814	Major facilitator Superfamily
AHiyo4_10240	COG0861	Integral membrane protein TerC family
AHiyo4_10370	COG4232	protein-disulfide reductase activity
AHiyo4_10390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AHiyo4_10390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AHiyo4_10470	COG2149	membrane
AHiyo4_10500	COG2814	Major facilitator Superfamily
AHiyo4_10540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AHiyo4_10600	COG1937	Protein conserved in bacteria
AHiyo4_10630	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AHiyo4_10720	COG1063	alcohol dehydrogenase
AHiyo4_10780	COG0515	serine threonine protein kinase
AHiyo4_10820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AHiyo4_10860	COG5002	protein histidine kinase activity
AHiyo4_10960	COG0574	Belongs to the PEP-utilizing enzyme family
AHiyo4_10960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AHiyo4_10970	COG0385	Bile acid
AHiyo4_10980	COG1115	amino acid carrier protein
AHiyo4_10990	COG1115	amino acid carrier protein
AHiyo4_11010	COG0246	Mannitol dehydrogenase
AHiyo4_11020	COG0246	Mannitol dehydrogenase
AHiyo4_11030	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AHiyo4_11050	COG0640	Transcriptional regulator
AHiyo4_11240	COG0477	Major facilitator Superfamily
AHiyo4_11250	COG1609	Transcriptional regulator
AHiyo4_11260	COG1609	Transcriptional regulator
AHiyo4_11270	COG0667	Aldo Keto reductase
AHiyo4_11320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AHiyo4_11330	COG1113	amino acid transport
AHiyo4_11340	COG0833	amino acid
AHiyo4_11470	COG3284	Transcriptional regulator
AHiyo4_11550	COG2072	flavoprotein involved in K transport
AHiyo4_11560	COG1063	alcohol dehydrogenase
AHiyo4_11570	COG1063	alcohol dehydrogenase
AHiyo4_11630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AHiyo4_11650	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AHiyo4_11690	COG1609	Transcriptional regulator
AHiyo4_11700	COG1609	Transcriptional regulator
AHiyo4_11750	COG1129	ABC transporter
AHiyo4_11760	COG1172	Belongs to the binding-protein-dependent transport system permease family
AHiyo4_11770	COG1172	Belongs to the binding-protein-dependent transport system permease family
AHiyo4_11780	COG0673	inositol 2-dehydrogenase activity
AHiyo4_11820	COG2337	Toxic component of a toxin-antitoxin (TA) module
AHiyo4_11870	COG1115	amino acid carrier protein
AHiyo4_11890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AHiyo4_11940	COG2186	Transcriptional regulator
AHiyo4_11990	COG3540	Alkaline phosphatase
AHiyo4_12070	COG4942	peptidase
AHiyo4_12110	COG1278	Cold shock
AHiyo4_12140	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AHiyo4_12150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AHiyo4_12180	COG2610	gluconate transmembrane transporter activity
AHiyo4_12270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AHiyo4_12310	COG3903	Transcriptional regulator
AHiyo4_12310	COG3629	intracellular signal transduction
AHiyo4_12350	COG3706	GGDEF domain
AHiyo4_12360	COG0745	RESPONSE REGULATOR receiver
AHiyo4_12370	COG0784	Response regulator, receiver
AHiyo4_12380	COG3437	response regulator, receiver
AHiyo4_12380	COG3850	Histidine kinase
AHiyo4_12380	COG4999	Histidine kinase
AHiyo4_12380	COG2205	protein histidine kinase activity
AHiyo4_12390	COG4191	Histidine kinase
AHiyo4_12420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AHiyo4_12420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AHiyo4_12430	COG2203	Gaf domain
AHiyo4_12430	COG2199	diguanylate cyclase activity
AHiyo4_12430	COG2200	EAL domain
AHiyo4_12450	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AHiyo4_12460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AHiyo4_12600	COG0477	Major facilitator Superfamily
AHiyo4_12610	COG0138	bifunctional purine biosynthesis protein purh
AHiyo4_12620	COG0138	bifunctional purine biosynthesis protein purh
AHiyo4_12700	COG0515	serine threonine protein kinase
AHiyo4_12740	COG0673	inositol 2-dehydrogenase activity
AHiyo4_12750	COG1136	(ABC) transporter
AHiyo4_12790	COG4213	ABC transporter substrate-binding protein
AHiyo4_12830	COG1129	ABC transporter
AHiyo4_12900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AHiyo4_12910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AHiyo4_12920	COG0531	amino acid
AHiyo4_12980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AHiyo4_13000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AHiyo4_13050	COG0180	Tryptophanyl-tRNA synthetase
AHiyo4_13060	COG0180	Tryptophanyl-tRNA synthetase
AHiyo4_13120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AHiyo4_13150	COG2009	succinate dehydrogenase
AHiyo4_13170	COG1473	amidohydrolase
AHiyo4_13170	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AHiyo4_13180	COG1846	Transcriptional regulator
AHiyo4_13190	COG1764	response to oxidative stress
AHiyo4_13200	COG2130	NADP-dependent
AHiyo4_13210	COG2130	NADP-dependent
AHiyo4_13270	COG1079	Belongs to the binding-protein-dependent transport system permease family
AHiyo4_13330	COG0586	Pfam SNARE associated Golgi protein
AHiyo4_13340	COG0586	Pfam SNARE associated Golgi protein
AHiyo4_13360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AHiyo4_13370	COG3956	TIGRFAM MazG family protein
AHiyo4_13380	COG0148	phosphopyruvate hydratase activity
AHiyo4_13390	COG0148	phosphopyruvate hydratase activity
AHiyo4_13450	COG1404	Belongs to the peptidase S8 family
AHiyo4_13460	COG1404	Belongs to the peptidase S8 family
AHiyo4_13470	COG1252	NADH dehydrogenase
AHiyo4_13510	COG0410	ABC transporter
AHiyo4_13550	COG0559	Belongs to the binding-protein-dependent transport system permease family
AHiyo4_13570	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AHiyo4_13580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AHiyo4_13640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AHiyo4_13650	COG0705	Rhomboid family
AHiyo4_13660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AHiyo4_13680	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AHiyo4_13710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AHiyo4_13720	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AHiyo4_13730	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AHiyo4_13790	COG0114	fumarate hydratase activity
AHiyo4_13800	COG0288	reversible hydration of carbon dioxide
AHiyo4_13820	COG1494	fructose-1,6-bisphosphatase
AHiyo4_13850	COG1482	cell wall glycoprotein biosynthetic process
AHiyo4_13870	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AHiyo4_13880	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AHiyo4_14020	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AHiyo4_14170	COG0714	Associated with various cellular activities
AHiyo4_14180	COG0714	Associated with various cellular activities
AHiyo4_14200	COG0084	hydrolase, TatD family'
AHiyo4_14210	COG3584	3D domain protein
AHiyo4_14210	COG3583	domain protein
AHiyo4_14230	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AHiyo4_14240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AHiyo4_14250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AHiyo4_14260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AHiyo4_14270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AHiyo4_14280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AHiyo4_14300	COG0488	(ABC) transporter
AHiyo4_14330	COG1309	transcriptional regulator
AHiyo4_14340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AHiyo4_14350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AHiyo4_14360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AHiyo4_14370	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AHiyo4_14380	COG0193	aminoacyl-tRNA hydrolase activity
AHiyo4_14390	COG0193	aminoacyl-tRNA hydrolase activity
AHiyo4_14450	COG0822	iron-sulfur transferase activity
AHiyo4_14460	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AHiyo4_14510	COG0702	epimerase
AHiyo4_14540	COG1988	membrane-bound metal-dependent
AHiyo4_14570	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AHiyo4_14640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AHiyo4_14640	COG2146	nitrite reductase [NAD(P)H] activity
AHiyo4_14650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AHiyo4_14670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AHiyo4_14680	COG1959	2 iron, 2 sulfur cluster binding
AHiyo4_14750	COG0243	molybdopterin cofactor binding
AHiyo4_14760	COG2223	nitrite transmembrane transporter activity
AHiyo4_14770	COG0477	Major facilitator Superfamily
AHiyo4_14800	COG4770	biotin carboxylase activity
AHiyo4_14820	COG0424	maF-like protein
AHiyo4_14830	COG2409	Drug exporters of the RND superfamily
AHiyo4_14840	COG2409	Drug exporters of the RND superfamily
AHiyo4_14920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AHiyo4_14930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AHiyo4_14950	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo4_14960	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AHiyo4_14960	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AHiyo4_15060	COG0714	Associated with various cellular activities
AHiyo4_15150	COG0631	protein serine/threonine phosphatase activity
AHiyo4_15220	COG1674	ftsk spoiiie
AHiyo4_15230	COG1674	ftsk spoiiie
AHiyo4_15280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AHiyo4_15290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AHiyo4_15300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AHiyo4_15310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AHiyo4_15320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AHiyo4_15330	COG0483	inositol monophosphate 1-phosphatase activity
AHiyo4_15350	COG0251	oxidation-reduction process
AHiyo4_15360	COG4565	transcriptional regulatory protein
AHiyo4_15390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AHiyo4_15400	COG0154	amidase activity
AHiyo4_15410	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AHiyo4_15420	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AHiyo4_15450	COG0583	DNA-binding transcription factor activity
AHiyo4_15460	COG1063	alcohol dehydrogenase
AHiyo4_15470	COG0156	8-amino-7-oxononanoate synthase activity
AHiyo4_15500	COG1228	amidohydrolase
AHiyo4_15510	COG1228	amidohydrolase
AHiyo4_15590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AHiyo4_15600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AHiyo4_15610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AHiyo4_15730	COG2755	lipolytic protein G-D-S-L family
AHiyo4_15740	COG0400	carboxylic ester hydrolase activity
AHiyo4_15760	COG0423	glycine-tRNA ligase activity
AHiyo4_15880	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AHiyo4_15890	COG0358	DNA primase activity
AHiyo4_15900	COG0358	DNA primase activity
AHiyo4_15970	COG2814	Major facilitator Superfamily
AHiyo4_15990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AHiyo4_16040	COG0297	glycogen (starch) synthase activity
AHiyo4_16050	COG1960	acyl-CoA dehydrogenase activity
AHiyo4_16080	COG0052	Belongs to the universal ribosomal protein uS2 family
AHiyo4_16090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AHiyo4_16100	COG0528	UMP kinase activity
AHiyo4_16110	COG0233	cytoplasmic translational termination
AHiyo4_16130	COG0575	Belongs to the CDS family
AHiyo4_16150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AHiyo4_16190	COG3275	phosphorelay sensor kinase activity
AHiyo4_16210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AHiyo4_16260	COG0022	dehydrogenase e1 component
AHiyo4_16270	COG0022	dehydrogenase e1 component
AHiyo4_16280	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHiyo4_16300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AHiyo4_16350	COG1960	acyl-CoA dehydrogenase activity
AHiyo4_16470	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AHiyo4_16480	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AHiyo4_16490	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AHiyo4_16500	COG0750	zinc metalloprotease
AHiyo4_16530	COG0750	zinc metalloprotease
AHiyo4_16590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AHiyo4_16620	COG1309	transcriptional regulator
AHiyo4_16660	COG0442	prolyl-tRNA aminoacylation
AHiyo4_16670	COG0442	prolyl-tRNA aminoacylation
AHiyo4_16710	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
AHiyo4_16740	COG0779	Required for maturation of 30S ribosomal subunits
AHiyo4_16750	COG0195	Participates in both transcription termination and antitermination
AHiyo4_16780	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AHiyo4_16800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AHiyo4_16810	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AHiyo4_16820	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AHiyo4_16840	COG0590	tRNA wobble adenosine to inosine editing
AHiyo4_16860	COG0436	Aminotransferase
AHiyo4_16880	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AHiyo4_16900	COG0196	riboflavin kinase activity
AHiyo4_16920	COG3483	tryptophan 2,3-dioxygenase activity
AHiyo4_16940	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AHiyo4_16950	COG1185	polyribonucleotide nucleotidyltransferase activity
AHiyo4_16960	COG1185	polyribonucleotide nucleotidyltransferase activity
AHiyo4_16970	COG0612	Peptidase, M16
AHiyo4_16980	COG0612	Peptidase, M16
AHiyo4_17150	COG0315	cyclic pyranopterin monophosphate synthase activity
AHiyo4_17160	COG0521	Mo-molybdopterin cofactor biosynthetic process
AHiyo4_17180	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AHiyo4_17240	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AHiyo4_17240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AHiyo4_17250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AHiyo4_17260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AHiyo4_17280	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AHiyo4_17290	COG1674	ftsk spoiiie
AHiyo4_17300	COG1674	ftsk spoiiie
AHiyo4_17330	COG1058	Belongs to the CinA family
AHiyo4_17330	COG1546	Belongs to the CinA family
AHiyo4_17350	COG1396	sequence-specific DNA binding
AHiyo4_17370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AHiyo4_17380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AHiyo4_17390	COG2137	regulation of response to DNA damage stimulus
AHiyo4_17400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AHiyo4_17410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AHiyo4_17420	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AHiyo4_17430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AHiyo4_17440	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AHiyo4_17450	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AHiyo4_17460	COG2813	Specifically methylates the guanine in position
AHiyo4_17470	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AHiyo4_17490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AHiyo4_17510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AHiyo4_17520	COG0131	Imidazoleglycerol-phosphate dehydratase
AHiyo4_17530	COG0131	Imidazoleglycerol-phosphate dehydratase
AHiyo4_17540	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AHiyo4_17560	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AHiyo4_17610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AHiyo4_17620	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AHiyo4_17630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AHiyo4_17640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AHiyo4_17670	COG2814	Major facilitator Superfamily
AHiyo4_17680	COG2814	Major facilitator Superfamily
AHiyo4_17690	COG2814	Major facilitator Superfamily
AHiyo4_17740	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AHiyo4_17750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AHiyo4_17750	COG0072	phenylalanine-tRNA ligase activity
AHiyo4_17760	COG0072	phenylalanine-tRNA ligase activity
AHiyo4_17760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AHiyo4_17770	COG0072	phenylalanine-tRNA ligase activity
AHiyo4_17770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AHiyo4_17820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AHiyo4_17840	COG0318	PFAM AMP-dependent synthetase and ligase
AHiyo4_17850	COG0604	alcohol dehydrogenase
AHiyo4_17890	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AHiyo4_17900	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AHiyo4_17910	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AHiyo4_17920	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AHiyo4_17930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AHiyo4_17940	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AHiyo4_17950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AHiyo4_17960	COG1438	arginine binding
AHiyo4_17970	COG0137	argininosuccinate synthase activity
AHiyo4_17980	COG0165	Argininosuccinate lyase
AHiyo4_18010	COG2169	Transcriptional regulator
AHiyo4_18010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AHiyo4_18040	COG2094	Belongs to the DNA glycosylase MPG family
AHiyo4_18080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AHiyo4_18110	COG0647	UMP catabolic process
AHiyo4_18160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AHiyo4_18170	COG0497	DNA recombination
AHiyo4_18180	COG0497	DNA recombination
AHiyo4_18190	COG0504	CTP synthase activity
AHiyo4_18250	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AHiyo4_18260	COG2079	MmgE PrpD family protein
AHiyo4_18280	COG2079	MmgE PrpD family protein
AHiyo4_18310	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AHiyo4_18320	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AHiyo4_18330	COG4565	transcriptional regulatory protein
AHiyo4_18350	COG3290	protein histidine kinase activity
AHiyo4_18370	COG1301	dicarboxylic acid transport
AHiyo4_18380	COG1301	dicarboxylic acid transport
AHiyo4_18400	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AHiyo4_18410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AHiyo4_18440	COG0287	Prephenate dehydrogenase
AHiyo4_18450	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AHiyo4_18460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AHiyo4_18480	COG1160	GTP binding
AHiyo4_18490	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AHiyo4_18530	COG0509	glycine decarboxylation via glycine cleavage system
AHiyo4_18540	COG1716	ATPase activity
AHiyo4_18610	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AHiyo4_18620	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AHiyo4_18630	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AHiyo4_18660	COG1940	carbohydrate kinase activity
AHiyo4_18670	COG1940	carbohydrate kinase activity
AHiyo4_18760	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AHiyo4_18790	COG2815	serine threonine protein kinase
AHiyo4_18790	COG0515	serine threonine protein kinase
AHiyo4_18800	COG0515	serine threonine protein kinase
AHiyo4_18800	COG2815	serine threonine protein kinase
AHiyo4_18810	COG0741	lytic transglycosylase activity
AHiyo4_18820	COG1388	LysM domain
AHiyo4_18820	COG3942	CHAP domain
AHiyo4_18910	COG2001	Belongs to the MraZ family
AHiyo4_18920	COG0275	rRNA processing
AHiyo4_18930	COG0275	rRNA processing
AHiyo4_18960	COG0768	penicillin binding
AHiyo4_18970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AHiyo4_18980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AHiyo4_18990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AHiyo4_19000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AHiyo4_19010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AHiyo4_19020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AHiyo4_19030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AHiyo4_19040	COG0772	Belongs to the SEDS family
AHiyo4_19050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AHiyo4_19060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AHiyo4_19090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AHiyo4_19120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AHiyo4_19130	COG1799	cell septum assembly
AHiyo4_19160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AHiyo4_19190	COG0587	DNA-directed DNA polymerase activity
AHiyo4_19200	COG0587	DNA-directed DNA polymerase activity
AHiyo4_19230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AHiyo4_19240	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AHiyo4_19280	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AHiyo4_19290	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AHiyo4_19300	COG0174	glutamine synthetase
AHiyo4_19320	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AHiyo4_19340	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AHiyo4_19400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AHiyo4_19410	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AHiyo4_19420	COG0321	lipoyl(octanoyl) transferase activity
AHiyo4_19460	COG1090	epimerase
AHiyo4_19480	COG4946	Tricorn protease homolog
AHiyo4_19480	COG0793	Belongs to the peptidase S41A family
AHiyo4_19490	COG4946	Tricorn protease homolog
AHiyo4_19490	COG0793	Belongs to the peptidase S41A family
AHiyo4_19500	COG0793	Belongs to the peptidase S41A family
AHiyo4_19500	COG4946	Tricorn protease homolog
AHiyo4_19510	COG4946	Tricorn protease homolog
AHiyo4_19510	COG0793	Belongs to the peptidase S41A family
AHiyo4_19520	COG4946	Tricorn protease homolog
AHiyo4_19520	COG0793	Belongs to the peptidase S41A family
AHiyo4_19570	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHiyo4_19580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AHiyo4_19600	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AHiyo4_19680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AHiyo4_19710	COG0187	DNA topoisomerase II activity
AHiyo4_19720	COG0187	DNA topoisomerase II activity
AHiyo4_19750	COG1271	oxidase subunit
AHiyo4_19760	COG1294	oxidase, subunit
AHiyo4_19770	COG4988	ABC transporter
AHiyo4_19780	COG4988	ABC transporter
AHiyo4_19790	COG1131	(ABC) transporter
AHiyo4_19800	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AHiyo4_19850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AHiyo4_19860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AHiyo4_19870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AHiyo4_19870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AHiyo4_19970	COG0756	dUTP diphosphatase activity
AHiyo4_20030	COG0569	domain protein
AHiyo4_20040	COG0531	amino acid
AHiyo4_20050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AHiyo4_20070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AHiyo4_20080	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AHiyo4_20090	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AHiyo4_20100	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AHiyo4_20120	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AHiyo4_20130	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AHiyo4_20140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AHiyo4_20150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AHiyo4_20180	COG0667	Aldo Keto reductase
AHiyo4_20250	COG1122	ATPase activity
AHiyo4_20260	COG1122	ATPase activity
AHiyo4_20270	COG1250	3-hydroxyacyl-CoA dehydrogenase
AHiyo4_20270	COG1024	Enoyl-CoA hydratase
AHiyo4_20280	COG1024	Enoyl-CoA hydratase
AHiyo4_20280	COG1250	3-hydroxyacyl-CoA dehydrogenase
AHiyo4_20300	COG0183	Belongs to the thiolase family
AHiyo4_20310	COG0183	Belongs to the thiolase family
AHiyo4_20330	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AHiyo4_20390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AHiyo4_20450	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AHiyo4_20530	COG0242	peptide deformylase activity
AHiyo4_20540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AHiyo4_20550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AHiyo4_20560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AHiyo4_20580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AHiyo4_20600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AHiyo4_20600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AHiyo4_20650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AHiyo4_20650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AHiyo4_20660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AHiyo4_20670	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AHiyo4_20680	COG0140	phosphoribosyl-ATP diphosphatase activity
AHiyo4_20690	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AHiyo4_20700	COG0107	imidazoleglycerol-phosphate synthase activity
AHiyo4_20720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AHiyo4_20770	COG0134	indole-3-glycerol-phosphate synthase activity
AHiyo4_20790	COG0133	tryptophan synthase activity
AHiyo4_20800	COG0159	tryptophan synthase activity
AHiyo4_20820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AHiyo4_20850	COG0070	glutamate synthase
AHiyo4_20850	COG0069	glutamate synthase activity
AHiyo4_20850	COG0067	glutamate synthase
AHiyo4_20860	COG0069	glutamate synthase activity
AHiyo4_20860	COG0067	glutamate synthase
AHiyo4_20860	COG0070	glutamate synthase
AHiyo4_20870	COG0070	glutamate synthase
AHiyo4_20870	COG0069	glutamate synthase activity
AHiyo4_20870	COG0067	glutamate synthase
AHiyo4_20890	COG0067	glutamate synthase
AHiyo4_20890	COG0069	glutamate synthase activity
AHiyo4_20890	COG0070	glutamate synthase
AHiyo4_20900	COG0070	glutamate synthase
AHiyo4_20900	COG0069	glutamate synthase activity
AHiyo4_20900	COG0067	glutamate synthase
AHiyo4_21230	COG0459	protein refolding
AHiyo4_21240	COG0459	protein refolding
AHiyo4_21250	COG0459	protein refolding
AHiyo4_21270	COG1063	alcohol dehydrogenase
AHiyo4_21390	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AHiyo4_21520	COG1396	sequence-specific DNA binding
AHiyo4_21530	COG2124	cytochrome p450
AHiyo4_21560	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AHiyo4_21570	COG0156	8-amino-7-oxononanoate synthase activity
AHiyo4_21580	COG0156	8-amino-7-oxononanoate synthase activity
AHiyo4_21600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AHiyo4_21620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AHiyo4_21630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AHiyo4_21660	COG4974	Belongs to the 'phage' integrase family
AHiyo4_21740	COG0559	Belongs to the binding-protein-dependent transport system permease family
AHiyo4_21750	COG0559	Belongs to the binding-protein-dependent transport system permease family
AHiyo4_21760	COG0411	ABC transporter
AHiyo4_21770	COG0410	ABC transporter
AHiyo4_21830	COG1053	succinate dehydrogenase
AHiyo4_21850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AHiyo4_21870	COG2079	MmgE PrpD family protein
AHiyo4_21890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AHiyo4_21930	COG2801	Transposase and inactivated derivatives
AHiyo4_21990	COG1793	dna ligase
AHiyo4_21990	COG3285	dna ligase
AHiyo4_22060	COG3971	2-oxopent-4-enoate hydratase activity
AHiyo4_22070	COG3971	2-oxopent-4-enoate hydratase activity
AHiyo4_22140	COG1070	Carbohydrate kinase
AHiyo4_22150	COG1070	Carbohydrate kinase
AHiyo4_22160	COG2115	Belongs to the xylose isomerase family
AHiyo4_22170	COG2115	Belongs to the xylose isomerase family
AHiyo4_22180	COG0277	FAD linked oxidase domain protein
AHiyo4_22250	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AHiyo4_22260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AHiyo4_22360	COG0405	Gamma-glutamyltransferase
AHiyo4_22420	COG1643	Atp-dependent helicase
AHiyo4_22430	COG1643	Atp-dependent helicase
AHiyo4_22470	COG0009	L-threonylcarbamoyladenylate synthase
AHiyo4_22600	COG2050	protein possibly involved in aromatic compounds catabolism
AHiyo4_22650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AHiyo4_22650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AHiyo4_22670	COG4552	Acetyltransferase involved in intracellular survival and related
AHiyo4_22680	COG0539	negative regulation of cytoplasmic translation
AHiyo4_22720	COG0237	dephospho-CoA kinase activity
AHiyo4_22720	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AHiyo4_22730	COG0556	nucleotide-excision repair
AHiyo4_22740	COG0556	nucleotide-excision repair
AHiyo4_22750	COG0861	Integral membrane protein TerC family
AHiyo4_22770	COG0477	Major facilitator Superfamily
AHiyo4_22820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AHiyo4_22880	COG4106	trans-aconitate 2-methyltransferase activity
AHiyo4_22890	COG1132	(ABC) transporter
AHiyo4_22950	COG0546	phosphoglycolate phosphatase activity
AHiyo4_22970	COG0322	excinuclease ABC activity
AHiyo4_22990	COG1660	Displays ATPase and GTPase activities
AHiyo4_23010	COG1481	regulation of sporulation
AHiyo4_23020	COG1481	regulation of sporulation
AHiyo4_23030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AHiyo4_23040	COG0126	phosphoglycerate kinase activity
AHiyo4_23050	COG0149	triose-phosphate isomerase activity
AHiyo4_23060	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AHiyo4_23080	COG0363	glucosamine-6-phosphate deaminase activity
AHiyo4_23120	COG0166	Belongs to the GPI family
AHiyo4_23130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AHiyo4_23140	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AHiyo4_23170	COG0109	protoheme IX farnesyltransferase activity
AHiyo4_23190	COG1612	heme a metabolic process
AHiyo4_23240	COG0719	Fe-S assembly protein
AHiyo4_23260	COG0719	Fe-S assembly protein
AHiyo4_23290	COG0396	ATPase activity
AHiyo4_23300	COG0396	ATPase activity
AHiyo4_23310	COG2151	metal-sulfur cluster biosynthetic enzyme
AHiyo4_23340	COG0318	PFAM AMP-dependent synthetase and ligase
AHiyo4_23360	COG0183	Belongs to the thiolase family
AHiyo4_23390	COG1122	ATPase activity
AHiyo4_23400	COG1268	BioY protein
AHiyo4_23410	COG0488	(ABC) transporter
AHiyo4_23470	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo4_23480	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo4_23510	COG3830	Belongs to the UPF0237 family
AHiyo4_23510	COG0560	Phosphoserine phosphatase
AHiyo4_23520	COG1119	ATPase activity
AHiyo4_23560	COG3619	membrane
AHiyo4_23670	COG0254	rRNA binding
AHiyo4_23700	COG2855	membrane
AHiyo4_23720	COG2308	Evidence 4 Homologs of previously reported genes of
AHiyo4_23780	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AHiyo4_23790	COG0297	glycogen (starch) synthase activity
AHiyo4_23800	COG0297	glycogen (starch) synthase activity
AHiyo4_23860	COG0183	Belongs to the thiolase family
AHiyo4_23870	COG0183	Belongs to the thiolase family
AHiyo4_23950	COG0435	Glutathione S-transferase
AHiyo4_24010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AHiyo4_24050	COG0667	Aldo Keto reductase
AHiyo4_24060	COG1968	undecaprenyl-diphosphatase activity
AHiyo4_24070	COG1968	undecaprenyl-diphosphatase activity
AHiyo4_24080	COG0215	cysteine-tRNA ligase activity
AHiyo4_24100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AHiyo4_24110	COG1994	Peptidase M50
AHiyo4_24110	COG0517	IMP dehydrogenase activity
AHiyo4_24130	COG1222	aaa ATPase
AHiyo4_24140	COG1222	aaa ATPase
AHiyo4_24150	COG4122	O-methyltransferase activity
AHiyo4_24160	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AHiyo4_24170	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AHiyo4_24180	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AHiyo4_24190	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AHiyo4_24200	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AHiyo4_24210	COG0545	Peptidyl-prolyl cis-trans isomerase
AHiyo4_24240	COG2378	regulation of single-species biofilm formation
AHiyo4_24270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AHiyo4_24280	COG0805	protein transport
AHiyo4_24310	COG4581	dead DEAH box helicase
AHiyo4_24340	COG1216	Glycosyl transferase, family 2
AHiyo4_24350	COG1216	Glycosyl transferase, family 2
AHiyo4_24430	COG1506	peptidase
AHiyo4_24430	COG0823	Involved in the tonB-independent uptake of proteins
AHiyo4_24430	COG4946	Tricorn protease homolog
AHiyo4_24440	COG0242	peptide deformylase activity
AHiyo4_24470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AHiyo4_24480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AHiyo4_24520	COG3424	synthase
AHiyo4_24640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AHiyo4_24650	COG1845	cytochrome c oxidase, subunit III
AHiyo4_24660	COG1845	cytochrome c oxidase, subunit III
AHiyo4_24690	COG0723	plastoquinol--plastocyanin reductase activity
AHiyo4_24700	COG0723	plastoquinol--plastocyanin reductase activity
AHiyo4_24710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AHiyo4_24720	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AHiyo4_24760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AHiyo4_24780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AHiyo4_24790	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AHiyo4_24840	COG0167	dihydroorotate dehydrogenase activity
AHiyo4_24860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AHiyo4_24870	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AHiyo4_24880	COG1381	Involved in DNA repair and RecF pathway recombination
AHiyo4_24890	COG1381	Involved in DNA repair and RecF pathway recombination
AHiyo4_24900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AHiyo4_24910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AHiyo4_24920	COG3590	peptidase
AHiyo4_24930	COG1316	TRANSCRIPTIONal
AHiyo4_24940	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AHiyo4_24950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AHiyo4_24970	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AHiyo4_24980	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AHiyo4_25030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AHiyo4_25040	COG0484	heat shock protein binding
AHiyo4_25060	COG1420	regulation of RNA biosynthetic process
AHiyo4_25070	COG1420	regulation of RNA biosynthetic process
AHiyo4_25130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AHiyo4_25150	COG0481	GTPase activity
AHiyo4_25160	COG0481	GTPase activity
AHiyo4_25170	COG0481	GTPase activity
AHiyo4_25190	COG0268	Binds directly to 16S ribosomal RNA
AHiyo4_25280	COG1307	EDD domain protein, DegV family
AHiyo4_25290	COG1307	EDD domain protein, DegV family
AHiyo4_25300	COG0495	leucyl-tRNA aminoacylation
AHiyo4_25350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AHiyo4_25370	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AHiyo4_25380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AHiyo4_25390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AHiyo4_25410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AHiyo4_25440	COG0656	L-ascorbic acid biosynthetic process
AHiyo4_25460	COG0438	transferase activity, transferring glycosyl groups
AHiyo4_25490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AHiyo4_25510	COG1758	RNA polymerase activity
AHiyo4_25520	COG0194	GDP metabolic process
AHiyo4_25530	COG0194	GDP metabolic process
AHiyo4_25540	COG0284	orotidine-5'-phosphate decarboxylase activity
AHiyo4_25560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AHiyo4_25570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AHiyo4_25590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AHiyo4_25600	COG0505	Belongs to the CarA family
AHiyo4_25620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AHiyo4_25630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AHiyo4_25640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AHiyo4_25650	COG0540	Belongs to the ATCase OTCase family
AHiyo4_25660	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AHiyo4_25720	COG1484	DNA-dependent DNA replication
AHiyo4_25760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AHiyo4_25770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AHiyo4_25780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AHiyo4_25790	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AHiyo4_25810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AHiyo4_25820	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AHiyo4_25830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AHiyo4_25850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AHiyo4_25880	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AHiyo4_25900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AHiyo4_25910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AHiyo4_25920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AHiyo4_25930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AHiyo4_25970	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AHiyo4_26010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AHiyo4_26020	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AHiyo4_26030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AHiyo4_26070	COG0124	histidyl-tRNA synthetase
AHiyo4_26110	COG1196	nuclear chromosome segregation
AHiyo4_26130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AHiyo4_26150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AHiyo4_26160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AHiyo4_26170	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AHiyo4_26180	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AHiyo4_26200	COG2255	four-way junction helicase activity
AHiyo4_26210	COG0632	four-way junction helicase activity
AHiyo4_26220	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AHiyo4_26230	COG0217	transcriptional regulatory protein
AHiyo4_26240	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AHiyo4_26250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AHiyo4_26290	COG0339	signal peptide processing
AHiyo4_26300	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AHiyo4_26310	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AHiyo4_26340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AHiyo4_26350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AHiyo4_26370	COG0587	DNA-directed DNA polymerase activity
AHiyo4_26380	COG0587	DNA-directed DNA polymerase activity
AHiyo4_26390	COG0587	DNA-directed DNA polymerase activity
AHiyo4_26470	COG2135	peptidase activity
AHiyo4_26510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AHiyo4_26690	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AHiyo4_26730	COG1960	acyl-CoA dehydrogenase activity
AHiyo4_26750	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AHiyo4_26820	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo4_26860	COG0723	plastoquinol--plastocyanin reductase activity
AHiyo4_26960	COG1819	glycosyl
AHiyo4_27000	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AHiyo4_27020	COG1131	(ABC) transporter
AHiyo4_27100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AHiyo4_27130	COG4106	trans-aconitate 2-methyltransferase activity
AHiyo4_27160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AHiyo4_27190	COG0640	Transcriptional regulator
AHiyo4_27310	COG1136	(ABC) transporter
AHiyo4_27310	COG0577	efflux transmembrane transporter activity
AHiyo4_27420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AHiyo4_27520	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AHiyo4_27530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AHiyo4_27540	COG1780	Probably involved in ribonucleotide reductase function
AHiyo4_27590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AHiyo4_27600	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AHiyo4_27630	COG0493	'glutamate synthase
AHiyo4_27640	COG0583	DNA-binding transcription factor activity
AHiyo4_27680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AHiyo4_27770	COG0714	Associated with various cellular activities
AHiyo4_27800	COG0395	ABC-type sugar transport system, permease component
AHiyo4_27880	COG2824	Alkylphosphonate utilization operon protein PhnA
AHiyo4_27890	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AHiyo4_27900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AHiyo4_27910	COG0799	negative regulation of ribosome biogenesis
AHiyo4_27950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AHiyo4_27970	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AHiyo4_27980	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AHiyo4_27990	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AHiyo4_28000	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AHiyo4_28010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AHiyo4_28020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AHiyo4_28040	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AHiyo4_28050	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AHiyo4_28060	COG0351	phosphomethylpyrimidine kinase
AHiyo4_28060	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AHiyo4_28060	COG0352	thiamine-phosphate diphosphorylase activity
AHiyo4_28080	COG1530	ribonuclease E activity
AHiyo4_28090	COG1530	ribonuclease E activity
AHiyo4_28140	COG0285	dihydrofolate synthase activity
AHiyo4_28150	COG0285	dihydrofolate synthase activity
AHiyo4_28160	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AHiyo4_28170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AHiyo4_28180	COG0584	glycerophosphoryl diester phosphodiesterase
AHiyo4_28210	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo4_28230	COG0525	valine-tRNA ligase activity
AHiyo4_28240	COG0525	valine-tRNA ligase activity
AHiyo4_28250	COG0525	valine-tRNA ligase activity
AHiyo4_28260	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AHiyo4_28270	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AHiyo4_28280	COG0740	serine-type endopeptidase activity
AHiyo4_28290	COG0740	serine-type endopeptidase activity
AHiyo4_28300	COG0740	serine-type endopeptidase activity
AHiyo4_28310	COG0544	peptidyl-prolyl cis-trans isomerase activity
AHiyo4_28430	COG0668	transmembrane transport
AHiyo4_28450	COG1946	Acyl-CoA thioesterase
AHiyo4_28520	COG0673	inositol 2-dehydrogenase activity
AHiyo4_28530	COG0673	inositol 2-dehydrogenase activity
AHiyo4_28540	COG1609	Transcriptional regulator
AHiyo4_28600	COG0242	peptide deformylase activity
AHiyo4_28670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AHiyo4_28680	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AHiyo4_28690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AHiyo4_28710	COG1045	serine acetyltransferase
AHiyo4_28720	COG0300	oxidoreductase activity
AHiyo4_28730	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AHiyo4_28770	COG1063	alcohol dehydrogenase
AHiyo4_28790	COG1063	alcohol dehydrogenase
AHiyo4_28800	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo4_28840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AHiyo4_28850	COG0477	Major facilitator Superfamily
AHiyo4_28920	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AHiyo4_28930	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AHiyo4_28940	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AHiyo4_28980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AHiyo4_28990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AHiyo4_29000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AHiyo4_29010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AHiyo4_29030	COG4974	Belongs to the 'phage' integrase family
AHiyo4_29070	COG0792	nuclease activity
AHiyo4_29090	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AHiyo4_29110	COG0681	Belongs to the peptidase S26 family
AHiyo4_29130	COG0335	large ribosomal subunit rRNA binding
AHiyo4_29140	COG0336	Belongs to the RNA methyltransferase TrmD family
AHiyo4_29150	COG0336	Belongs to the RNA methyltransferase TrmD family
AHiyo4_29160	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AHiyo4_29170	COG0228	four-way junction DNA binding
AHiyo4_29190	COG2514	catechol 2,3-dioxygenase activity
AHiyo4_29200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AHiyo4_29220	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AHiyo4_29290	COG0004	ammonium transporteR
AHiyo4_29330	COG0477	Major facilitator Superfamily
AHiyo4_29350	COG1196	nuclear chromosome segregation
AHiyo4_29380	COG1196	nuclear chromosome segregation
AHiyo4_29400	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AHiyo4_29410	COG0571	ribonuclease III activity
AHiyo4_29420	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AHiyo4_29450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AHiyo4_29460	COG0436	Aminotransferase
AHiyo4_29480	COG0742	ribosomal rna small subunit methyltransferase
AHiyo4_29580	COG1181	Belongs to the D-alanine--D-alanine ligase family
AHiyo4_29590	COG1181	Belongs to the D-alanine--D-alanine ligase family
AHiyo4_29610	COG1181	Belongs to the D-alanine--D-alanine ligase family
AHiyo4_29620	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AHiyo4_29630	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AHiyo4_29640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AHiyo4_29660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AHiyo4_29670	COG0066	3-isopropylmalate dehydratase activity
AHiyo4_29680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AHiyo4_29700	COG1414	Transcriptional regulator
AHiyo4_29810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AHiyo4_29820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AHiyo4_29890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AHiyo4_29900	COG0473	3-isopropylmalate dehydrogenase activity
AHiyo4_29950	COG1136	(ABC) transporter
AHiyo4_29950	COG0577	efflux transmembrane transporter activity
AHiyo4_30000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AHiyo4_30010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AHiyo4_30020	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AHiyo4_30030	COG0440	acetolactate synthase activity
AHiyo4_30070	COG0129	dihydroxy-acid dehydratase activity
AHiyo4_30090	COG0088	Forms part of the polypeptide exit tunnel
AHiyo4_30160	COG0747	negative chemotaxis
AHiyo4_30170	COG0579	oxidoreductase
AHiyo4_30180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AHiyo4_30190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AHiyo4_30200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AHiyo4_30230	COG1305	Transglutaminase-like
AHiyo4_30250	COG0179	Fumarylacetoacetate (FAA) hydrolase
AHiyo4_30280	COG1104	cysteine desulfurase activity
AHiyo4_30290	COG1104	cysteine desulfurase activity
AHiyo4_30330	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AHiyo4_30340	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AHiyo4_30350	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AHiyo4_30360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AHiyo4_30380	COG1113	amino acid transport
AHiyo4_30390	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHiyo4_30440	COG1414	Transcriptional regulator
AHiyo4_30490	COG0419	ATPase involved in DNA repair
AHiyo4_30510	COG0419	ATPase involved in DNA repair
AHiyo4_30540	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AHiyo4_30580	COG0586	Pfam SNARE associated Golgi protein
AHiyo4_30600	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AHiyo4_30610	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AHiyo4_30620	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AHiyo4_30640	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AHiyo4_30660	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AHiyo4_30690	COG1335	isochorismatase
AHiyo4_30710	COG1061	Type III restriction enzyme res subunit
AHiyo4_30740	COG0363	glucosamine-6-phosphate deaminase activity
AHiyo4_30900	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AHiyo4_30920	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AHiyo4_30930	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AHiyo4_30950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AHiyo4_30960	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AHiyo4_30970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AHiyo4_30980	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AHiyo4_30990	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AHiyo4_31010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AHiyo4_31020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AHiyo4_31030	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AHiyo4_31040	COG0356	it plays a direct role in the translocation of protons across the membrane
AHiyo4_31080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AHiyo4_31090	COG1216	Glycosyl transferase, family 2
AHiyo4_31160	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AHiyo4_31190	COG0083	homoserine kinase activity
AHiyo4_31200	COG0083	homoserine kinase activity
AHiyo4_31210	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AHiyo4_31220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AHiyo4_31230	COG0460	homoserine dehydrogenase
AHiyo4_31240	COG0460	homoserine dehydrogenase
AHiyo4_31250	COG0460	homoserine dehydrogenase
AHiyo4_31260	COG0019	diaminopimelate decarboxylase activity
AHiyo4_31280	COG0019	diaminopimelate decarboxylase activity
AHiyo4_31290	COG0018	arginyl-trna synthetase
AHiyo4_31400	COG1643	Atp-dependent helicase
AHiyo4_31410	COG1643	Atp-dependent helicase
AHiyo4_31420	COG1643	Atp-dependent helicase
AHiyo4_31430	COG1643	Atp-dependent helicase
AHiyo4_31440	COG1643	Atp-dependent helicase
AHiyo4_31450	COG1643	Atp-dependent helicase
AHiyo4_31470	COG1064	alcohol dehydrogenase
AHiyo4_31480	COG1064	alcohol dehydrogenase
AHiyo4_31550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AHiyo4_31570	COG3842	ATPase activity
AHiyo4_31600	COG0803	Belongs to the bacterial solute-binding protein 9 family
AHiyo4_31640	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHiyo4_31640	COG0567	Dehydrogenase, E1 component
AHiyo4_31660	COG0567	Dehydrogenase, E1 component
AHiyo4_31660	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHiyo4_31710	COG1595	DNA-templated transcription, initiation
AHiyo4_31720	COG1595	DNA-templated transcription, initiation
AHiyo4_31760	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AHiyo4_31770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AHiyo4_31800	COG0483	inositol monophosphate 1-phosphatase activity
AHiyo4_31810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AHiyo4_31820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AHiyo4_31870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AHiyo4_31900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AHiyo4_31920	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AHiyo4_31950	COG2884	Cell division ATP-binding protein ftsE
AHiyo4_31960	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AHiyo4_32090	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AHiyo4_32120	COG1086	Polysaccharide biosynthesis protein
AHiyo4_32130	COG1216	Glycosyl transferase, family 2
AHiyo4_32180	COG1088	dTDP-glucose 4,6-dehydratase activity
AHiyo4_32200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AHiyo4_32260	COG0463	Glycosyl transferase, family 2
AHiyo4_32270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AHiyo4_32290	COG1215	transferase activity, transferring glycosyl groups
AHiyo4_32360	COG1216	Glycosyl transferase, family 2
AHiyo4_32390	COG1674	ftsk spoiiie
AHiyo4_32460	COG2902	Dehydrogenase
AHiyo4_32470	COG2902	Dehydrogenase
AHiyo4_32480	COG2902	Dehydrogenase
AHiyo4_32490	COG2902	Dehydrogenase
AHiyo4_32580	COG0653	protein targeting
AHiyo4_32590	COG3214	Protein conserved in bacteria
AHiyo4_32600	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AHiyo4_32620	COG5401	PFAM Sporulation and spore germination
AHiyo4_32630	COG5002	protein histidine kinase activity
AHiyo4_32640	COG5002	protein histidine kinase activity
AHiyo4_32680	COG0745	RESPONSE REGULATOR receiver
AHiyo4_32740	COG0714	Associated with various cellular activities
AHiyo4_32800	COG4172	Belongs to the ABC transporter superfamily
AHiyo4_32820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AHiyo4_32830	COG0601	transmembrane transport
AHiyo4_32870	COG0482	sulfurtransferase activity
AHiyo4_32880	COG0482	sulfurtransferase activity
AHiyo4_32970	COG0484	heat shock protein binding
AHiyo4_32980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AHiyo4_32990	COG1595	DNA-templated transcription, initiation
AHiyo4_33020	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AHiyo4_33060	COG1842	Phage shock protein A
AHiyo4_33070	COG0415	Belongs to the DNA photolyase family
AHiyo4_33080	COG0415	Belongs to the DNA photolyase family
AHiyo4_33100	COG1615	UPF0182 protein
AHiyo4_33110	COG1615	UPF0182 protein
AHiyo4_33120	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AHiyo4_33160	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AHiyo4_33220	COG2816	NAD+ diphosphatase activity
AHiyo4_33360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AHiyo4_33380	COG0765	amino acid transport
AHiyo4_33390	COG1126	abc transporter atp-binding protein
AHiyo4_33400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AHiyo4_33420	COG0113	porphobilinogen synthase activity
AHiyo4_33450	COG0181	hydroxymethylbilane synthase activity
AHiyo4_33460	COG0181	hydroxymethylbilane synthase activity
AHiyo4_33540	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AHiyo4_33560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AHiyo4_33610	COG2154	pterin-4-alpha-carbinolamine dehydratase
AHiyo4_33620	COG2022	thiamine diphosphate biosynthetic process
AHiyo4_33630	COG2022	thiamine diphosphate biosynthetic process
AHiyo4_33660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AHiyo4_33670	COG0352	thiamine-phosphate diphosphorylase activity
AHiyo4_33700	COG0513	Belongs to the DEAD box helicase family
AHiyo4_33770	COG0006	proline dipeptidase activity
AHiyo4_33820	COG0395	ABC-type sugar transport system, permease component
AHiyo4_33870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AHiyo4_33890	COG1595	DNA-templated transcription, initiation
AHiyo4_33900	COG4122	O-methyltransferase activity
AHiyo4_33950	COG1126	abc transporter atp-binding protein
AHiyo4_33960	COG1126	abc transporter atp-binding protein
AHiyo4_33970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AHiyo4_34000	COG0765	amino acid transport
AHiyo4_34020	COG0765	amino acid transport
AHiyo4_34030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AHiyo4_34040	COG2171	N-acyltransferase activity
AHiyo4_34050	COG2171	N-acyltransferase activity
AHiyo4_34100	COG3226	Transcriptional regulator
AHiyo4_34120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AHiyo4_34220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AHiyo4_34300	COG0012	GTP binding
AHiyo4_34310	COG0012	GTP binding
AHiyo4_34320	COG1322	Protein conserved in bacteria
AHiyo4_34330	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AHiyo4_34350	COG1570	exodeoxyribonuclease VII activity
AHiyo4_34360	COG1570	exodeoxyribonuclease VII activity
AHiyo4_34370	COG1722	exodeoxyribonuclease VII activity
AHiyo4_34380	COG2326	polyphosphate kinase activity
AHiyo4_34440	COG1174	glycine betaine transport
AHiyo4_34490	COG2971	BadF BadG BcrA BcrD
AHiyo4_34520	COG0583	DNA-binding transcription factor activity
AHiyo4_34530	COG2814	Major facilitator Superfamily
AHiyo4_34590	COG0598	Magnesium transport protein CorA
AHiyo4_34600	COG0488	(ABC) transporter
AHiyo4_34610	COG0366	Alpha amylase catalytic
AHiyo4_34620	COG1070	Carbohydrate kinase
AHiyo4_34660	COG1172	Belongs to the binding-protein-dependent transport system permease family
AHiyo4_34680	COG1609	Transcriptional regulator
AHiyo4_34690	COG1609	Transcriptional regulator
AHiyo4_34720	COG0667	Aldo Keto reductase
AHiyo4_34780	COG0395	ABC-type sugar transport system, permease component
AHiyo4_34820	COG1940	carbohydrate kinase activity
AHiyo4_34830	COG0363	glucosamine-6-phosphate deaminase activity
AHiyo4_34860	COG2801	Transposase and inactivated derivatives
AHiyo4_34880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AHiyo4_34940	COG2826	transposase and inactivated derivatives, IS30 family
AHiyo4_34990	COG3328	transposase activity
AHiyo4_35000	COG3328	transposase activity
AHiyo4_35040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AHiyo4_35110	COG0519	Catalyzes the synthesis of GMP from XMP
AHiyo4_35110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AHiyo4_35170	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AHiyo4_35180	COG0516	GMP reductase activity
AHiyo4_35210	COG1404	Belongs to the peptidase S8 family
AHiyo4_35220	COG1404	Belongs to the peptidase S8 family
AHiyo4_35240	COG0516	GMP reductase activity
AHiyo4_35240	COG0517	IMP dehydrogenase activity
AHiyo4_35320	COG2072	flavoprotein involved in K transport
AHiyo4_35330	COG2197	response regulator
AHiyo4_35350	COG1793	dna ligase
AHiyo4_35360	COG1793	dna ligase
AHiyo4_35370	COG1793	dna ligase
AHiyo4_35380	COG0459	protein refolding
AHiyo4_35390	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AHiyo4_35430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AHiyo4_35450	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AHiyo4_35460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AHiyo4_35470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AHiyo4_35480	COG0456	acetyltransferase
AHiyo4_35500	COG0802	atpase or kinase
AHiyo4_35510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AHiyo4_35520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AHiyo4_35530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AHiyo4_35610	COG0438	transferase activity, transferring glycosyl groups
AHiyo4_35620	COG0438	transferase activity, transferring glycosyl groups
AHiyo4_35630	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AHiyo4_35640	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AHiyo4_35650	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AHiyo4_35670	COG1260	myo-inositol-1-phosphate synthase
AHiyo4_35680	COG0667	Aldo Keto reductase
AHiyo4_35800	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AHiyo4_35800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AHiyo4_35820	COG0736	holo-[acyl-carrier-protein] synthase activity
AHiyo4_35870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AHiyo4_35880	COG1072	(Pantothenic acid kinase))
AHiyo4_35900	COG1876	peptidase activity
AHiyo4_35930	COG1970	mechanosensitive ion channel activity
AHiyo4_35940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AHiyo4_35960	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AHiyo4_35970	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AHiyo4_35980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AHiyo4_36060	COG2894	cell division
AHiyo4_36160	COG1192	Involved in chromosome partitioning
AHiyo4_36210	COG0745	RESPONSE REGULATOR receiver
AHiyo4_36230	COG5002	protein histidine kinase activity
AHiyo4_36240	COG0101	tRNA pseudouridine synthase activity
AHiyo4_36250	COG0101	tRNA pseudouridine synthase activity
AHiyo4_36260	COG0203	ribosomal protein L17
AHiyo4_36270	COG0202	RNA polymerase activity
AHiyo4_36280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AHiyo4_36290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AHiyo4_36300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AHiyo4_36310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AHiyo4_36320	COG3191	aminopeptidase activity
AHiyo4_36370	COG0563	adenylate kinase activity
AHiyo4_36390	COG0200	Binds to the 23S rRNA
AHiyo4_36400	COG1841	ribosomal large subunit assembly
AHiyo4_36410	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AHiyo4_36430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AHiyo4_36440	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AHiyo4_36450	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AHiyo4_36460	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AHiyo4_36470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AHiyo4_36480	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AHiyo4_36490	COG0255	Belongs to the universal ribosomal protein uL29 family
AHiyo4_36500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AHiyo4_36510	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AHiyo4_36520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AHiyo4_36530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AHiyo4_36540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AHiyo4_36550	COG0089	rRNA binding
AHiyo4_36560	COG0088	Forms part of the polypeptide exit tunnel
AHiyo4_36570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AHiyo4_36580	COG0051	transcription antitermination factor activity, RNA binding
AHiyo4_36590	COG2723	6-phospho-beta-galactosidase activity
AHiyo4_36650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AHiyo4_36670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AHiyo4_36680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AHiyo4_36690	COG0049	tRNA binding
AHiyo4_36700	COG0049	tRNA binding
AHiyo4_36710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AHiyo4_36720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AHiyo4_36730	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AHiyo4_36740	COG0085	RNA polymerase activity
AHiyo4_36750	COG0085	RNA polymerase activity
AHiyo4_36770	COG0183	Belongs to the thiolase family
AHiyo4_36780	COG0442	prolyl-tRNA aminoacylation
AHiyo4_36790	COG0222	ribosome binding
AHiyo4_36800	COG0222	ribosome binding
AHiyo4_36810	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AHiyo4_36850	COG0081	regulation of translation
AHiyo4_36860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AHiyo4_36900	COG0436	Aminotransferase
AHiyo4_36920	COG2197	response regulator
AHiyo4_37070	COG0354	folic acid binding
AHiyo4_37100	COG3485	protocatechuate 3,4-dioxygenase
AHiyo4_37150	COG0745	RESPONSE REGULATOR receiver
AHiyo4_37160	COG0456	acetyltransferase
AHiyo4_37170	COG0456	acetyltransferase
AHiyo4_37190	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AHiyo4_37210	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AHiyo4_37220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AHiyo4_37250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AHiyo4_37300	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AHiyo4_37310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AHiyo4_37320	COG0738	Major facilitator superfamily
AHiyo4_37330	COG0738	Major facilitator superfamily
AHiyo4_37350	COG2030	dehydratase
AHiyo4_37390	COG0659	secondary active sulfate transmembrane transporter activity
AHiyo4_37450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AHiyo4_37540	COG4989	oxidoreductase activity
AHiyo4_37620	COG1940	carbohydrate kinase activity
AHiyo4_37670	COG0706	membrane insertase activity
AHiyo4_37740	COG0754	glutathionylspermidine amidase activity
AHiyo4_37780	COG1960	acyl-CoA dehydrogenase activity
AHiyo4_38000	COG0318	PFAM AMP-dependent synthetase and ligase
AHiyo4_38010	COG0318	PFAM AMP-dependent synthetase and ligase
AHiyo4_38030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AHiyo4_38040	COG1131	(ABC) transporter
AHiyo4_38080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AHiyo4_38130	COG2801	Transposase and inactivated derivatives
AHiyo4_38160	COG4974	Belongs to the 'phage' integrase family
AHiyo4_38310	COG0582	viral genome integration into host DNA
AHiyo4_38330	COG1666	GTP binding
AHiyo4_38340	COG0501	Belongs to the peptidase M48B family
AHiyo4_38390	COG0753	catalase activity
AHiyo4_38420	COG0531	amino acid
AHiyo4_38430	COG0531	amino acid
AHiyo4_38440	COG3344	reverse transcriptase
AHiyo4_38580	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo4_38590	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo4_38650	COG2186	Transcriptional regulator
AHiyo4_38680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AHiyo4_38680	COG1648	precorrin-2 dehydrogenase activity
AHiyo4_38690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AHiyo4_38690	COG1648	precorrin-2 dehydrogenase activity
AHiyo4_38760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AHiyo4_38770	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AHiyo4_38790	COG1690	Belongs to the RtcB family
AHiyo4_38820	COG0175	sulfate reduction
AHiyo4_38840	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AHiyo4_38850	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AHiyo4_38890	COG2860	membrane
AHiyo4_38970	COG2226	methyltransferase
AHiyo4_39000	COG1169	isochorismate synthase
AHiyo4_39010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AHiyo4_39040	COG0765	amino acid transport
AHiyo4_39070	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AHiyo4_39080	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AHiyo4_39090	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AHiyo4_39100	COG1609	Transcriptional regulator
AHiyo4_39150	COG0395	ABC-type sugar transport system, permease component
AHiyo4_39220	COG4948	Mandelate Racemase Muconate Lactonizing
AHiyo4_39310	COG1609	Transcriptional regulator
AHiyo4_39320	COG1609	Transcriptional regulator
AHiyo4_39360	COG0395	ABC-type sugar transport system, permease component
AHiyo4_39370	COG1175	transmembrane transport
AHiyo4_39420	COG2801	Transposase and inactivated derivatives
AHiyo4_39540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AHiyo4_39550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AHiyo4_39680	COG3300	MHYT domain
AHiyo4_39680	COG5001	Diguanylate cyclase
AHiyo4_39700	COG3422	double-strand break repair
AHiyo4_39720	COG2329	Antibiotic biosynthesis monooxygenase
AHiyo4_39760	COG2205	protein histidine kinase activity
AHiyo4_39760	COG2202	Pas domain
AHiyo4_39770	COG0745	RESPONSE REGULATOR receiver
AHiyo4_39790	COG0745	RESPONSE REGULATOR receiver
AHiyo4_39800	COG0745	RESPONSE REGULATOR receiver
AHiyo4_39820	COG1215	transferase activity, transferring glycosyl groups
AHiyo4_39940	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHiyo4_39950	COG0022	dehydrogenase e1 component
AHiyo4_40070	COG3206	protein involved in exopolysaccharide biosynthesis
AHiyo4_40070	COG0489	protein tyrosine kinase activity
AHiyo4_40100	COG2801	Transposase and inactivated derivatives
AHiyo4_40170	COG0438	transferase activity, transferring glycosyl groups
AHiyo4_40180	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AHiyo4_40210	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AHiyo4_40250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AHiyo4_40260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AHiyo4_40300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AHiyo4_40310	COG2151	metal-sulfur cluster biosynthetic enzyme
AHiyo4_40320	COG3396	Phenylacetate-CoA oxygenase
AHiyo4_40330	COG3460	Phenylacetate-CoA oxygenase
AHiyo4_40340	COG3396	Phenylacetate-CoA oxygenase
AHiyo4_40400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AHiyo4_40410	COG0318	PFAM AMP-dependent synthetase and ligase
AHiyo4_40480	COG0574	Belongs to the PEP-utilizing enzyme family
AHiyo4_40480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AHiyo4_40520	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AHiyo4_40570	COG2026	Addiction module toxin, RelE StbE family
AHiyo4_40610	COG1113	amino acid transport
AHiyo4_40630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AHiyo4_40640	COG1760	l-serine dehydratase
AHiyo4_40670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AHiyo4_40680	COG0509	glycine decarboxylation via glycine cleavage system
AHiyo4_40690	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AHiyo4_40700	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AHiyo4_40710	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_40710	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_40720	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_40720	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_40730	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_40730	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_40740	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_40740	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_40750	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_40750	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo4_40850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AHiyo4_40930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AHiyo4_40940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AHiyo4_40980	COG0857	belongs to the CobB CobQ family
AHiyo4_40980	COG0280	phosphate acetyltransferase
AHiyo4_41000	COG2050	protein possibly involved in aromatic compounds catabolism
AHiyo4_41020	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AHiyo4_41030	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AHiyo4_41060	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo4_41060	COG2030	dehydratase
AHiyo4_41070	COG2030	dehydratase
AHiyo4_41070	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo4_41080	COG2050	protein possibly involved in aromatic compounds catabolism
AHiyo4_41130	COG2755	lipolytic protein G-D-S-L family
AHiyo4_41140	COG1250	3-hydroxyacyl-CoA dehydrogenase
AHiyo4_41160	COG1024	Enoyl-CoA hydratase
AHiyo4_41170	COG0183	Belongs to the thiolase family
AHiyo4_41180	COG0183	Belongs to the thiolase family
AHiyo4_41260	COG2146	nitrite reductase [NAD(P)H] activity
AHiyo4_41270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AHiyo4_41280	COG0488	(ABC) transporter
AHiyo4_41290	COG0488	(ABC) transporter
AHiyo4_41300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AHiyo4_41320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AHiyo4_41330	COG1121	(ABC) transporter
AHiyo4_41350	COG1266	CAAX protease self-immunity
AHiyo4_41360	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AHiyo4_41490	COG0443	Heat shock 70 kDa protein
AHiyo4_41500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AHiyo4_41520	COG0785	Cytochrome C biogenesis protein
AHiyo4_41550	COG3118	belongs to the thioredoxin family
AHiyo4_41560	COG0406	alpha-ribazole phosphatase activity
AHiyo4_41600	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AHiyo4_41620	COG0560	Phosphoserine phosphatase
AHiyo4_41640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AHiyo4_41660	COG3458	cephalosporin-C deacetylase activity
AHiyo4_41910	COG1609	Transcriptional regulator
AHiyo4_41930	COG2188	Transcriptional regulator
AHiyo4_42000	COG0640	Transcriptional regulator
AHiyo4_42030	COG0123	including yeast histone deacetylase and acetoin utilization protein
AHiyo4_42040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AHiyo4_42050	COG0569	domain protein
AHiyo4_42060	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AHiyo4_42070	COG0248	Ppx GppA phosphatase
AHiyo4_42080	COG0248	Ppx GppA phosphatase
AHiyo4_42110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AHiyo4_42110	COG1754	DNA topoisomerase type I activity
AHiyo4_42120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AHiyo4_42120	COG1754	DNA topoisomerase type I activity
AHiyo4_42130	COG1754	DNA topoisomerase type I activity
AHiyo4_42130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AHiyo4_42140	COG1754	DNA topoisomerase type I activity
AHiyo4_42140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AHiyo4_42150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AHiyo4_42150	COG1754	DNA topoisomerase type I activity
AHiyo4_42180	COG2890	protein-(glutamine-N5) methyltransferase activity
AHiyo4_42250	COG1205	dead DEAH box helicase
AHiyo4_42250	COG1111	helicase
AHiyo4_42460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AHiyo4_42470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AHiyo4_42520	COG1349	DNA-binding transcription factor activity
AHiyo4_42540	COG1609	Transcriptional regulator
AHiyo4_42560	COG4209	transmembrane transport
AHiyo4_42570	COG0395	ABC-type sugar transport system, permease component
AHiyo4_42630	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AHiyo4_42710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AHiyo4_42750	COG1132	(ABC) transporter
AHiyo4_42760	COG1132	(ABC) transporter
AHiyo4_42770	COG1132	(ABC) transporter
AHiyo4_42820	COG2801	Transposase and inactivated derivatives
AHiyo4_42840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AHiyo4_42850	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AHiyo4_42860	COG0151	Belongs to the GarS family
AHiyo4_42870	COG0151	Belongs to the GarS family
AHiyo4_42940	COG3387	PFAM Glycoside hydrolase 15-related
AHiyo4_42950	COG3387	PFAM Glycoside hydrolase 15-related
AHiyo4_42960	COG3387	PFAM Glycoside hydrolase 15-related
AHiyo4_43030	COG0484	heat shock protein binding
AHiyo4_43040	COG0071	Belongs to the small heat shock protein (HSP20) family
AHiyo4_43090	COG4335	DNA alkylation repair
AHiyo4_43130	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo4_43240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AHiyo4_43250	COG0563	adenylate kinase activity
AHiyo4_43280	COG0745	RESPONSE REGULATOR receiver
AHiyo4_43310	COG2267	carboxylic ester hydrolase activity
AHiyo4_43320	COG2267	carboxylic ester hydrolase activity
AHiyo4_43400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AHiyo4_43560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AHiyo4_43610	COG1473	amidohydrolase
AHiyo4_43630	COG0477	Major facilitator Superfamily
AHiyo4_43750	COG1597	lipid kinase activity
AHiyo4_43760	COG3639	organic phosphonate transmembrane transporter activity
AHiyo4_43810	COG2271	Major facilitator Superfamily
AHiyo4_43820	COG1802	Transcriptional regulator
AHiyo4_43870	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AHiyo4_43880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AHiyo4_43890	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AHiyo4_43940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AHiyo4_43940	COG2010	Cytochrome c
AHiyo4_43950	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AHiyo4_43970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AHiyo4_43980	COG2080	2 iron, 2 sulfur cluster binding
AHiyo4_43980	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AHiyo4_43990	COG2080	2 iron, 2 sulfur cluster binding
AHiyo4_44020	COG3608	succinylglutamate desuccinylase aspartoacylase
AHiyo4_44020	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AHiyo4_44030	COG2252	PERMEase
AHiyo4_44040	COG2252	PERMEase
AHiyo4_44050	COG0590	tRNA wobble adenosine to inosine editing
AHiyo4_44100	COG2233	PERMEase
AHiyo4_44110	COG1414	Transcriptional regulator
AHiyo4_44150	COG3257	ureidoglycine aminohydrolase activity
AHiyo4_44190	COG0656	L-ascorbic acid biosynthetic process
AHiyo4_44200	COG0656	L-ascorbic acid biosynthetic process
AHiyo4_44220	COG3338	carbonate dehydratase activity
AHiyo4_44300	COG3622	Belongs to the hyi family
AHiyo4_44310	COG2084	Dehydrogenase
AHiyo4_44320	COG3960	tartronate-semialdehyde synthase activity
AHiyo4_44330	COG3960	tartronate-semialdehyde synthase activity
AHiyo4_44340	COG3960	tartronate-semialdehyde synthase activity
AHiyo4_44350	COG1929	Belongs to the glycerate kinase type-1 family
AHiyo4_44360	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AHiyo4_44390	COG1620	l-lactate permease
AHiyo4_44400	COG0277	FAD linked oxidase domain protein
AHiyo4_44410	COG0277	FAD linked oxidase domain protein
AHiyo4_44420	COG2188	Transcriptional regulator
AHiyo4_44440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AHiyo4_44450	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AHiyo4_44510	COG1063	alcohol dehydrogenase
AHiyo4_44520	COG0395	ABC-type sugar transport system, permease component
AHiyo4_44700	COG2130	NADP-dependent
AHiyo4_44780	COG1126	abc transporter atp-binding protein
AHiyo4_44820	COG1172	Belongs to the binding-protein-dependent transport system permease family
AHiyo4_44850	COG1609	Transcriptional regulator
AHiyo4_44870	COG2124	cytochrome p450
AHiyo4_44900	COG2801	Transposase and inactivated derivatives
AHiyo4_44950	COG2267	carboxylic ester hydrolase activity
AHiyo4_45020	COG1358	cellular component organization or biogenesis
AHiyo4_45160	COG0531	amino acid
AHiyo4_45200	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AHiyo4_45220	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo4_45230	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo4_45260	COG4336	lyase activity
AHiyo4_45300	COG0745	RESPONSE REGULATOR receiver
AHiyo4_45340	COG0583	DNA-binding transcription factor activity
AHiyo4_45370	COG1250	3-hydroxyacyl-CoA dehydrogenase
AHiyo4_45370	COG1024	Enoyl-CoA hydratase
AHiyo4_45380	COG1250	3-hydroxyacyl-CoA dehydrogenase
AHiyo4_45380	COG1024	Enoyl-CoA hydratase
AHiyo4_45400	COG1024	Enoyl-CoA hydratase
AHiyo4_45400	COG1250	3-hydroxyacyl-CoA dehydrogenase
AHiyo4_45410	COG0183	Belongs to the thiolase family
AHiyo4_45420	COG0183	Belongs to the thiolase family
AHiyo4_45430	COG0183	Belongs to the thiolase family
AHiyo4_45450	COG1960	acyl-CoA dehydrogenase activity
AHiyo4_45510	COG0066	3-isopropylmalate dehydratase activity
AHiyo4_45520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AHiyo4_45530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AHiyo4_45540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AHiyo4_45550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AHiyo4_45570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AHiyo4_45600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AHiyo4_45660	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
AHiyo4_45690	COG1335	isochorismatase
AHiyo4_45780	COG3845	ABC transporter
AHiyo4_45790	COG0596	Alpha beta hydrolase
AHiyo4_45820	COG0646	methionine synthase
AHiyo4_45820	COG1410	methionine synthase
AHiyo4_45830	COG1410	methionine synthase
AHiyo4_45830	COG0646	methionine synthase
AHiyo4_45840	COG1410	methionine synthase
AHiyo4_45840	COG0646	methionine synthase
AHiyo4_45970	COG2801	Transposase and inactivated derivatives
AHiyo4_45990	COG3118	belongs to the thioredoxin family
AHiyo4_46060	COG2801	Transposase and inactivated derivatives
AHiyo4_46080	COG2205	protein histidine kinase activity
AHiyo4_46210	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AHiyo4_46220	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AHiyo4_46230	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AHiyo4_46350	COG1595	DNA-templated transcription, initiation
AHiyo4_46400	COG3384	dioxygenase
AHiyo4_46420	COG0028	Belongs to the TPP enzyme family
AHiyo4_46460	COG2066	Belongs to the glutaminase family
AHiyo4_46490	COG1309	transcriptional regulator
AHiyo4_46680	COG1228	amidohydrolase
AHiyo4_46760	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AHiyo4_46780	COG2986	histidine ammonia-lyase
AHiyo4_46790	COG5002	protein histidine kinase activity
AHiyo4_46850	COG1280	lysine exporter protein (LysE YggA)
AHiyo4_46920	COG0745	RESPONSE REGULATOR receiver
AHiyo4_46930	COG1215	transferase activity, transferring glycosyl groups
AHiyo4_46950	COG1366	Belongs to the anti-sigma-factor antagonist family
AHiyo4_47000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AHiyo4_47070	COG2318	DinB family
AHiyo4_47120	COG1116	anion transmembrane transporter activity
AHiyo4_47180	COG3585	molybdate ion transport
AHiyo4_47250	COG0135	phosphoribosylanthranilate isomerase activity
AHiyo4_47280	COG1528	Iron-storage protein
AHiyo4_47320	COG0572	uridine kinase
AHiyo4_47350	COG0513	Belongs to the DEAD box helicase family
AHiyo4_47360	COG0513	Belongs to the DEAD box helicase family
AHiyo4_47410	COG2807	transmembrane transport
AHiyo4_47430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AHiyo4_47600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AHiyo4_47680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AHiyo4_47700	COG0363	glucosamine-6-phosphate deaminase activity
AHiyo4_47720	COG1263	PTS System
AHiyo4_47720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AHiyo4_47740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AHiyo4_47740	COG2190	(PTS) system
AHiyo4_47740	COG1263	PTS System
AHiyo4_47750	COG2188	Transcriptional regulator
AHiyo4_47790	COG0410	ABC transporter
AHiyo4_47800	COG1137	ATPase activity
AHiyo4_47810	COG0411	ABC transporter
AHiyo4_47830	COG0559	Belongs to the binding-protein-dependent transport system permease family
AHiyo4_47850	COG0789	Transcriptional regulator
AHiyo4_47860	COG0484	heat shock protein binding
AHiyo4_47870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AHiyo4_47890	COG0443	Heat shock 70 kDa protein
AHiyo4_47940	COG2409	Drug exporters of the RND superfamily
AHiyo4_47950	COG2409	Drug exporters of the RND superfamily
AHiyo4_48010	COG1280	lysine exporter protein (LysE YggA)
AHiyo4_48040	COG0512	Glutamine amidotransferase of anthranilate synthase
AHiyo4_48040	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AHiyo4_48050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AHiyo4_48100	COG0183	Belongs to the thiolase family
AHiyo4_48110	COG0183	Belongs to the thiolase family
AHiyo4_48220	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AHiyo4_48230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AHiyo4_48260	COG1122	ATPase activity
AHiyo4_48270	COG4721	ABC-type cobalt transport system, permease component
AHiyo4_48280	COG4702	Belongs to the UPF0303 family
AHiyo4_48290	COG1320	monovalent cation:proton antiporter activity
AHiyo4_48300	COG2212	antiporter activity
AHiyo4_48330	COG1006	Multisubunit Na H antiporter MnhC subunit
AHiyo4_48340	COG2111	Na H antiporter
AHiyo4_48340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AHiyo4_48350	COG2111	Na H antiporter
AHiyo4_48350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AHiyo4_48380	COG0569	domain protein
AHiyo4_48380	COG2985	domain, Protein
AHiyo4_48390	COG0475	glutathione-regulated potassium exporter activity
AHiyo4_48410	COG0717	Belongs to the dCTP deaminase family
AHiyo4_48480	COG0583	DNA-binding transcription factor activity
AHiyo4_48530	COG0531	amino acid
AHiyo4_48540	COG0531	amino acid
AHiyo4_48550	COG0531	amino acid
AHiyo4_48560	COG0583	DNA-binding transcription factor activity
AHiyo4_48570	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AHiyo4_48610	COG3387	PFAM Glycoside hydrolase 15-related
AHiyo4_48660	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AHiyo4_48690	COG1175	transmembrane transport
AHiyo4_48720	COG1653	transport
AHiyo4_48730	COG1609	Transcriptional regulator
AHiyo4_48740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AHiyo4_48840	COG0433	COG0433 Predicted ATPase
AHiyo4_48850	COG0433	COG0433 Predicted ATPase
AHiyo4_48930	COG0776	regulation of translation
AHiyo4_48980	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AHiyo4_48990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AHiyo4_49000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AHiyo4_49040	COG3842	ATPase activity
AHiyo4_49110	COG1120	ATPase activity
AHiyo4_49120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AHiyo4_49130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AHiyo4_49140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AHiyo4_49150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AHiyo4_49330	COG0667	Aldo Keto reductase
AHiyo4_49340	COG0667	Aldo Keto reductase
AHiyo4_49350	COG0698	ribose 5-phosphate isomerase
AHiyo4_49370	COG2376	Dihydroxyacetone kinase
AHiyo4_49380	COG3958	Transketolase
AHiyo4_49400	COG0671	phosphoesterase, PA-phosphatase related
AHiyo4_49410	COG0586	Pfam SNARE associated Golgi protein
AHiyo4_49420	COG0745	RESPONSE REGULATOR receiver
AHiyo4_49440	COG5002	protein histidine kinase activity
AHiyo4_49450	COG2205	protein histidine kinase activity
AHiyo4_49530	COG3387	PFAM Glycoside hydrolase 15-related
AHiyo4_49540	COG2186	Transcriptional regulator
AHiyo4_49560	COG1027	Aspartate ammonia-lyase
AHiyo4_49570	COG0039	L-malate dehydrogenase activity
AHiyo4_49590	COG0784	Response regulator, receiver
AHiyo4_49590	COG5002	protein histidine kinase activity
AHiyo4_49590	COG2205	protein histidine kinase activity
AHiyo4_49650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AHiyo4_49720	COG1522	sequence-specific DNA binding
AHiyo4_49730	COG1280	lysine exporter protein (LysE YggA)
AHiyo4_49770	COG0281	malic enzyme
AHiyo4_49780	COG1309	transcriptional regulator
AHiyo4_49820	COG0477	Major facilitator Superfamily
AHiyo4_49850	COG0477	Major facilitator Superfamily
AHiyo4_49860	COG0477	Major facilitator Superfamily
AHiyo4_49880	COG0246	Mannitol dehydrogenase
AHiyo4_49890	COG0246	Mannitol dehydrogenase
AHiyo4_49900	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AHiyo4_49900	COG2213	PTS system mannitol-specific
AHiyo4_49920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AHiyo4_49930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AHiyo4_49970	COG0686	Belongs to the AlaDH PNT family
AHiyo4_49980	COG0686	Belongs to the AlaDH PNT family
AHiyo4_49990	COG0686	Belongs to the AlaDH PNT family
AHiyo4_50020	COG0673	inositol 2-dehydrogenase activity
AHiyo4_50050	COG4608	Belongs to the ABC transporter superfamily
AHiyo4_50110	COG1309	transcriptional regulator
AHiyo4_50120	COG0431	NADPH-dependent FMN reductase
AHiyo4_50150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AHiyo4_50200	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHiyo4_50210	COG0022	dehydrogenase e1 component
AHiyo4_50230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AHiyo4_50250	COG1950	PFAM Membrane protein of
AHiyo4_50280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AHiyo4_50290	COG0406	alpha-ribazole phosphatase activity
AHiyo4_50300	COG2902	Dehydrogenase
AHiyo4_50320	COG1607	acyl-coa hydrolase
AHiyo4_50340	COG1435	thymidine kinase activity
AHiyo4_50360	COG1597	lipid kinase activity
AHiyo4_50370	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AHiyo4_50380	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AHiyo4_50390	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AHiyo4_50400	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AHiyo4_50410	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AHiyo4_50420	COG1414	Transcriptional regulator
AHiyo4_50430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AHiyo4_50440	COG0477	Major facilitator Superfamily
AHiyo4_50450	COG1414	Transcriptional regulator
AHiyo4_50460	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AHiyo4_50470	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AHiyo4_50490	COG0183	Belongs to the thiolase family
AHiyo4_50500	COG0183	Belongs to the thiolase family
AHiyo4_50510	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AHiyo4_50550	COG3485	protocatechuate 3,4-dioxygenase
AHiyo4_50570	COG3485	protocatechuate 3,4-dioxygenase
AHiyo4_50600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AHiyo4_50610	COG1414	Transcriptional regulator
AHiyo4_50630	COG1793	dna ligase
AHiyo4_50640	COG1793	dna ligase
AHiyo4_50740	COG1937	Protein conserved in bacteria
AHiyo4_50860	COG0534	Mate efflux family protein
AHiyo4_50900	COG0305	Participates in initiation and elongation during chromosome replication
AHiyo4_50910	COG0305	Participates in initiation and elongation during chromosome replication
AHiyo4_51110	COG0359	binds to the 23S rRNA
AHiyo4_51120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AHiyo4_51140	COG0360	Binds together with S18 to 16S ribosomal RNA
AHiyo4_51160	COG2197	response regulator
AHiyo4_51170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase