locus-tag class description AHiyo8_00010 ENOG4105BZ4 penicillin-binding protein AHiyo8_00040 ENOG4105C0R drug resistance transporter emrb qaca subfamily AHiyo8_00060 ENOG4105C0R drug resistance transporter emrb qaca subfamily AHiyo8_00070 ENOG4108ZT1 Transcriptional regulator AHiyo8_00540 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AHiyo8_00770 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 AHiyo8_00880 ENOG41088T4 Helicase IV AHiyo8_00900 ENOG41088T4 Helicase IV AHiyo8_00910 ENOG41088T4 Helicase IV AHiyo8_01230 ENOG4105MZU cell filamentation protein AHiyo8_01460 ENOG4108TYN CAAX amino terminal protease family protein AHiyo8_01620 ENOG4105C0D helicase AHiyo8_01820 ENOG4105C4R Atp-dependent dna helicase AHiyo8_01970 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AHiyo8_02340 ENOG4105D85 methylase AHiyo8_02350 ENOG4105F6A helicase AHiyo8_02440 ENOG4105CSH Transporter AHiyo8_02450 ENOG4105CSH Transporter AHiyo8_02460 ENOG4105CSH Transporter AHiyo8_02510 ENOG4107RN6 Monooxygenase AHiyo8_02550 ENOG4105J4Q Transcriptional regulator AHiyo8_02590 ENOG4108KEZ Dehydrogenase AHiyo8_02620 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) AHiyo8_02650 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) AHiyo8_02690 ENOG4105E8R UPF0173 metal-dependent hydrolase AHiyo8_02760 ENOG4107RSM transcriptional regulator AHiyo8_02880 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AHiyo8_02910 ENOG4108KU9 integrase family AHiyo8_02990 ENOG4108QMY dioxygenase AHiyo8_03020 ENOG41069M3 Transcriptional regulator AHiyo8_03110 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AHiyo8_03150 ENOG4107RGD Major Facilitator superfamily AHiyo8_03170 ENOG4105C5I Dehydrogenase AHiyo8_03210 ENOG4106P37 HTH-type transcriptional regulator YjhI AHiyo8_03220 ENOG4105C2J ABC transporter AHiyo8_03240 ENOG4105C2J ABC transporter AHiyo8_03310 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AHiyo8_03330 ENOG4105CHR reductase AHiyo8_03340 ENOG4105CHR reductase AHiyo8_03350 ENOG4105CPQ Dehydrogenase AHiyo8_03360 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AHiyo8_03370 ENOG4107RHR regulatoR AHiyo8_03400 ENOG4105C54 Major Facilitator superfamily AHiyo8_03480 ENOG4108MRH transcriptional regulatory protein AHiyo8_03510 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AHiyo8_03600 ENOG4105F9F transposase AHiyo8_03840 ENOG4108IUX (ABC) transporter AHiyo8_03950 ENOG4105I1K ABC transporter AHiyo8_03960 ENOG4105CG3 alpha amylase, catalytic region AHiyo8_04050 ENOG4105I6B RNA polymerase AHiyo8_04090 ENOG4105CJN penicillin-binding protein AHiyo8_04100 ENOG4105CJN penicillin-binding protein AHiyo8_04110 ENOG4105CJN penicillin-binding protein AHiyo8_04130 ENOG4105NAF rna polymerase sigma factor AHiyo8_04220 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) AHiyo8_04240 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AHiyo8_04290 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) AHiyo8_04300 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) AHiyo8_04310 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AHiyo8_04320 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AHiyo8_04330 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AHiyo8_04340 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AHiyo8_04390 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AHiyo8_04430 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AHiyo8_04460 ENOG4107TB5 TRANSCRIPTIONal AHiyo8_04480 ENOG4105C9K Endothelin-converting enzyme 1 AHiyo8_04490 ENOG4105C9K Endothelin-converting enzyme 1 AHiyo8_04520 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AHiyo8_04530 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) AHiyo8_04540 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AHiyo8_04550 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AHiyo8_04560 ENOG4108EUD Lysophospholipase AHiyo8_04600 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein AHiyo8_04610 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AHiyo8_04620 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AHiyo8_04640 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AHiyo8_04660 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) AHiyo8_04670 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) AHiyo8_04680 ENOG4105BZ9 Cytochrome C oxidase, subunit I AHiyo8_04690 ENOG4105BZ9 Cytochrome C oxidase, subunit I AHiyo8_04700 ENOG4108ZRS Part of cytochrome c oxidase, its function is AHiyo8_04710 ENOG410849S phosphocarrier protein (HPr) AHiyo8_04720 ENOG4105FDP GntR family transcriptional regulator AHiyo8_04740 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AHiyo8_04750 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AHiyo8_04760 ENOG4107EUI c reductase, iron-sulfur AHiyo8_04770 ENOG4107UDY cytochrome C AHiyo8_04780 ENOG4105CCU oxidase (Subunit III) AHiyo8_04790 ENOG4108I0Q anthranilate phosphoribosyltransferase AHiyo8_04800 ENOG4108I0Q anthranilate phosphoribosyltransferase AHiyo8_04860 ENOG4107TB5 TRANSCRIPTIONal AHiyo8_04870 ENOG410829K Lysine exporter protein (Lyse ygga) AHiyo8_04920 ENOG4105D3W isochorismatase AHiyo8_04950 ENOG4105JAB phenazine biosynthesis protein, phzf family AHiyo8_05020 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AHiyo8_05030 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AHiyo8_05150 ENOG4105CSH Transporter AHiyo8_05160 ENOG4108JCI Transcriptional regulator AHiyo8_05190 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AHiyo8_05210 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AHiyo8_05230 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AHiyo8_05250 ENOG4105C26 Dehydrogenase AHiyo8_05270 ENOG4108Z4U Ferredoxin AHiyo8_05440 ENOG4105C9F isomerase AHiyo8_05460 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_05470 ENOG4105W1N transcriptional regulator AHiyo8_05520 ENOG4105C26 Dehydrogenase AHiyo8_05530 ENOG4105C26 Dehydrogenase AHiyo8_05590 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_05600 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_05610 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_05670 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AHiyo8_05680 ENOG4105DRS transport system, permease AHiyo8_05690 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) AHiyo8_05720 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) AHiyo8_05730 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) AHiyo8_05750 ENOG4105EF1 ribulokinase AHiyo8_05770 ENOG4105EF1 ribulokinase AHiyo8_05800 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_05820 ENOG4105CPQ Dehydrogenase AHiyo8_05850 ENOG4105BZP glycoside hydrolase 15-related AHiyo8_05900 ENOG4105C2J ABC transporter AHiyo8_05910 ENOG4105C2J ABC transporter AHiyo8_05920 ENOG4107RNG ABC transporter AHiyo8_06020 ENOG4105CEY Amp-dependent synthetase and ligase AHiyo8_06030 ENOG4105CEY Amp-dependent synthetase and ligase AHiyo8_06040 ENOG4108SHN Glycosyl transferase, family 2 AHiyo8_06120 ENOG4105C7I Dehydrogenase AHiyo8_06130 ENOG4105C7I Dehydrogenase AHiyo8_06140 ENOG4105C7I Dehydrogenase AHiyo8_06150 ENOG4105C7I Dehydrogenase AHiyo8_06180 ENOG4105D7N magnesium and cobalt transport protein CorA AHiyo8_06190 ENOG4108HQ0 Exopolysaccharide biosynthesis protein AHiyo8_06200 ENOG4105CVJ phosphoglycerate mutase AHiyo8_06250 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) AHiyo8_06270 ENOG4108IG5 Transcriptional regulator AHiyo8_06280 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase AHiyo8_06410 ENOG4105Q2H domain protein AHiyo8_06460 ENOG4105CHP RNA polymerase AHiyo8_06470 ENOG4105CHP RNA polymerase AHiyo8_06490 ENOG4105GRZ Ycii-related protein AHiyo8_06580 ENOG4105CJ1 ABC, transporter AHiyo8_06590 ENOG4105CJ1 ABC, transporter AHiyo8_06700 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase AHiyo8_06720 ENOG4105CPC Aldo Keto reductase AHiyo8_06730 ENOG4105E9Z Nad-dependent epimerase dehydratase AHiyo8_06760 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AHiyo8_06780 ENOG4108Z6Z Transcriptional regulator AHiyo8_06790 ENOG4105K63 Thioredoxin AHiyo8_06900 ENOG4107TVJ ,Oxidoreductase FAD NAD(P)-binding AHiyo8_06920 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) AHiyo8_06930 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) AHiyo8_07170 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AHiyo8_07280 ENOG4105HFS 5'-3' exonuclease AHiyo8_07340 ENOG4105C3M thioredoxin reductase AHiyo8_07390 ENOG41061ZR Transcriptional regulator AHiyo8_07470 ENOG4105D56 permease protein AHiyo8_07490 ENOG4105WEM extracellular solute-binding protein AHiyo8_07500 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_07510 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_07540 ENOG4105CHM Aminotransferase AHiyo8_07640 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AHiyo8_07680 ENOG4105EUJ GTP cyclohydrolase i AHiyo8_07690 ENOG4105EUJ GTP cyclohydrolase i AHiyo8_07700 ENOG4105E2A Dehydrogenase AHiyo8_07710 ENOG4105E2A Dehydrogenase AHiyo8_07760 ENOG4108IJ7 Glycine betaine AHiyo8_07770 ENOG4108IJ7 Glycine betaine AHiyo8_07790 ENOG4108HQS Glycine betaine AHiyo8_07830 ENOG4105CSH Transporter AHiyo8_07840 ENOG4105CSH Transporter AHiyo8_07860 ENOG4107RSM transcriptional regulator AHiyo8_07930 ENOG4107SET aldo keto reductase AHiyo8_07950 ENOG4106AM8 polysaccharide lyase family 8 AHiyo8_07980 ENOG4105DRS transport system, permease AHiyo8_08010 ENOG4105E98 transcriptional regulator DeoR family AHiyo8_08130 ENOG4105CY0 Metallo-Beta-Lactamase AHiyo8_08150 ENOG4105BZU Histidine kinase AHiyo8_08230 ENOG4105C59 p-type ATPase AHiyo8_08280 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AHiyo8_08300 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AHiyo8_08330 ENOG4107QRI Phosphoketolase AHiyo8_08350 ENOG4107QRI Phosphoketolase AHiyo8_08360 ENOG4107QRI Phosphoketolase AHiyo8_08480 ENOG4105CIG ABC transporter AHiyo8_08530 ENOG4105KAF membrAne AHiyo8_08560 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AHiyo8_08590 ENOG4105CK2 sodium dicarboxylate symporter AHiyo8_08600 ENOG4107QJT sodium dicarboxylate symporter AHiyo8_08700 ENOG41087EV Hsp20/alpha crystallin family AHiyo8_08710 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AHiyo8_08790 ENOG4105C2J ABC transporter AHiyo8_08810 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_08820 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AHiyo8_08870 ENOG4108JQ7 (ABC) transporter AHiyo8_08880 ENOG4108JQ7 (ABC) transporter AHiyo8_08910 ENOG4108HKT sucrose-6-phosphate hydrolase AHiyo8_08920 ENOG4108HKT sucrose-6-phosphate hydrolase AHiyo8_09010 ENOG4107QK4 glycoside hydrolase, family 3 domain protein AHiyo8_09050 ENOG41060H3 Protein of unknown function (DUF1049) AHiyo8_09130 ENOG41082JN Transcriptional regulator AHiyo8_09240 ENOG4107KJX Transcriptional regulator AHiyo8_09270 ENOG4105EDK PfkB domain protein AHiyo8_09280 ENOG4108HKT sucrose-6-phosphate hydrolase AHiyo8_09290 ENOG4108HKT sucrose-6-phosphate hydrolase AHiyo8_09390 ENOG4105DRS transport system, permease AHiyo8_09440 ENOG4107YY3 extracellular solute-binding protein family 1 AHiyo8_09500 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_09530 ENOG4108UHU Aldolase AHiyo8_09550 ENOG4105CSH Transporter AHiyo8_09560 ENOG4105CSH Transporter AHiyo8_09580 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AHiyo8_09600 ENOG4105CPC Aldo Keto reductase AHiyo8_09610 ENOG410630P Transcriptional regulator AHiyo8_09640 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AHiyo8_09710 ENOG4105CNT hydrolase family 2 AHiyo8_09780 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AHiyo8_09870 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AHiyo8_09880 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AHiyo8_09910 ENOG4105CS2 ec 3.2.1.21 AHiyo8_09930 ENOG4105CS2 ec 3.2.1.21 AHiyo8_09940 ENOG4105CI1 PTS System AHiyo8_09950 ENOG4105C5Y PTS System AHiyo8_09970 ENOG4105C5Y PTS System AHiyo8_10020 ENOG4107SET aldo keto reductase AHiyo8_10110 ENOG4105CBC glutamate synthase AHiyo8_10130 ENOG4105CBC glutamate synthase AHiyo8_10140 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AHiyo8_10170 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AHiyo8_10180 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AHiyo8_10190 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AHiyo8_10200 ENOG4105DK0 Indole-3-glycerol phosphate synthase AHiyo8_10240 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AHiyo8_10260 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AHiyo8_10270 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AHiyo8_10280 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase AHiyo8_10290 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AHiyo8_10300 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AHiyo8_10370 ENOG4105DJV ribulose-phosphate 3-epimerase AHiyo8_10400 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AHiyo8_10410 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AHiyo8_10440 ENOG4105BZU Histidine kinase AHiyo8_10460 ENOG4105CUB amino acid AHiyo8_10470 ENOG4105DKK Benzoate AHiyo8_10560 ENOG4105E0X reductase AHiyo8_10640 ENOG4105CHU acetyl-coa acetyltransferase AHiyo8_10660 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AHiyo8_10680 ENOG4105CPC Aldo Keto reductase AHiyo8_10710 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AHiyo8_10720 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AHiyo8_10730 ENOG4107QM5 aconitate hydratase AHiyo8_10740 ENOG4107QM5 aconitate hydratase AHiyo8_10750 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AHiyo8_10760 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AHiyo8_10770 ENOG4105C0X amino acid AHiyo8_10780 ENOG4107VEG TrkA-N domain protein AHiyo8_10840 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AHiyo8_10890 ENOG4107W53 thymidine kinase AHiyo8_10940 ENOG4105CD5 CoA-binding domain protein AHiyo8_10950 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AHiyo8_10990 ENOG4107QWG 2-Nitropropane dioxygenase AHiyo8_11000 ENOG4108JJ9 ABC, transporter AHiyo8_11030 ENOG4108JJ9 ABC, transporter AHiyo8_11040 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AHiyo8_11050 ENOG4105C4M (Ubiquinol oxidase) subunit I AHiyo8_11060 ENOG4105C4M (Ubiquinol oxidase) subunit I AHiyo8_11090 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AHiyo8_11110 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AHiyo8_11180 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AHiyo8_11260 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AHiyo8_11270 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AHiyo8_11330 ENOG4108Z9K Osmotically inducible protein AHiyo8_11340 ENOG4107RE3 peptidase, S41 AHiyo8_11350 ENOG4107RE3 peptidase, S41 AHiyo8_11370 ENOG4107RE3 peptidase, S41 AHiyo8_11380 ENOG4107RE3 peptidase, S41 AHiyo8_11400 ENOG4105ECP epimerase AHiyo8_11430 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AHiyo8_11440 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AHiyo8_11470 ENOG4105C5F glutamine synthetase AHiyo8_11510 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AHiyo8_11520 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AHiyo8_11540 ENOG4105C5F glutamine synthetase AHiyo8_11550 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AHiyo8_11580 ENOG4105DFK Polyphosphate glucokinase AHiyo8_11590 ENOG4105DFK Polyphosphate glucokinase AHiyo8_11600 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AHiyo8_11610 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AHiyo8_11620 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AHiyo8_11630 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AHiyo8_11660 ENOG4105C0B DNA polymerase III (alpha subunit) AHiyo8_11670 ENOG4105C0B DNA polymerase III (alpha subunit) AHiyo8_11680 ENOG4105C0B DNA polymerase III (alpha subunit) AHiyo8_11710 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AHiyo8_11760 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) AHiyo8_11770 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) AHiyo8_11780 ENOG4105DFA alanine racemase domain protein AHiyo8_11800 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AHiyo8_11810 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AHiyo8_11840 ENOG4105DFU Cell wall formation (By similarity) AHiyo8_11850 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AHiyo8_11860 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AHiyo8_11870 ENOG4105CNI cell division protein FtsW AHiyo8_11890 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AHiyo8_11900 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AHiyo8_11910 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AHiyo8_11920 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AHiyo8_11940 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AHiyo8_11970 ENOG4105CJN penicillin-binding protein AHiyo8_12000 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AHiyo8_12010 ENOG4108V6E Cell division protein mraZ AHiyo8_12030 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AHiyo8_12060 ENOG4105EAH synthase AHiyo8_12090 ENOG41068JE domain protein AHiyo8_12100 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division AHiyo8_12130 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase AHiyo8_12200 ENOG4105DKQ ROK family AHiyo8_12230 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AHiyo8_12240 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AHiyo8_12310 ENOG4108UW8 fha domain-containing protein AHiyo8_12330 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AHiyo8_12340 ENOG4105F27 Major Facilitator AHiyo8_12360 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) AHiyo8_12370 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AHiyo8_12380 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AHiyo8_12390 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AHiyo8_12420 ENOG4105CAT Cytidine monophosphate kinase AHiyo8_12470 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AHiyo8_12490 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AHiyo8_12510 ENOG4105CK2 sodium dicarboxylate symporter AHiyo8_12530 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AHiyo8_12540 ENOG4108MRH transcriptional regulatory protein AHiyo8_12570 ENOG4105DXD 2-methylcitrate dehydratase AHiyo8_12580 ENOG4105DXD 2-methylcitrate dehydratase AHiyo8_12680 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AHiyo8_12690 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AHiyo8_12720 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AHiyo8_12800 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AHiyo8_12810 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AHiyo8_12870 ENOG4108VX5 3-methyladenine DNA glycosylase AHiyo8_12900 ENOG4105CH7 arginosuccinase AHiyo8_12920 ENOG4105CDH Citrulline--aspartate ligase AHiyo8_12930 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) AHiyo8_12940 ENOG4105DBV ornithine carbamoyltransferase AHiyo8_12950 ENOG4105C8Y Acetylornithine aminotransferase AHiyo8_12960 ENOG4105C8Y Acetylornithine aminotransferase AHiyo8_12980 ENOG4105CAS nag kinase AHiyo8_12990 ENOG4105CAS nag kinase AHiyo8_13000 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AHiyo8_13020 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AHiyo8_13040 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AHiyo8_13140 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AHiyo8_13150 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AHiyo8_13160 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AHiyo8_13170 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AHiyo8_13190 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) AHiyo8_13230 ENOG4105F27 Major Facilitator AHiyo8_13240 ENOG4105F27 Major Facilitator AHiyo8_13260 ENOG4108RWN rrna methyltransferase AHiyo8_13270 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AHiyo8_13280 ENOG41084BS 50S ribosomal protein L35 AHiyo8_13290 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AHiyo8_13350 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AHiyo8_13370 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AHiyo8_13380 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AHiyo8_13390 ENOG4105CIH Imidazole acetol-phosphate transaminase AHiyo8_13410 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AHiyo8_13420 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AHiyo8_13450 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AHiyo8_13460 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AHiyo8_13470 ENOG4107Y49 methyltransferase AHiyo8_13480 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AHiyo8_13490 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AHiyo8_13500 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AHiyo8_13510 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AHiyo8_13530 ENOG4105KC9 Modulates RecA activity (By similarity) AHiyo8_13540 ENOG4105KC9 Modulates RecA activity (By similarity) AHiyo8_13550 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AHiyo8_13560 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AHiyo8_13590 ENOG4105WBV Transcriptional regulator AHiyo8_13600 ENOG4105CEV competence damage-inducible protein AHiyo8_13620 ENOG4107QZI cell division protein FtsK AHiyo8_13650 ENOG4105CN5 Metallo-Beta-Lactamase AHiyo8_13670 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AHiyo8_13710 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AHiyo8_13720 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AHiyo8_13730 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AHiyo8_13740 ENOG4108RIR Molybdenum cofactor biosynthesis protein AHiyo8_13750 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AHiyo8_13810 ENOG4105BZU Histidine kinase AHiyo8_13820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AHiyo8_13880 ENOG4105C1V Peptidase, M16 AHiyo8_13890 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AHiyo8_13900 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AHiyo8_13910 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AHiyo8_13920 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AHiyo8_13930 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AHiyo8_13970 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AHiyo8_13980 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AHiyo8_14010 ENOG4105CHM Aminotransferase AHiyo8_14020 ENOG4107Y2X deaminase AHiyo8_14030 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AHiyo8_14040 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AHiyo8_14050 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AHiyo8_14070 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AHiyo8_14100 ENOG4105CHV Transcription elongation factor NusA AHiyo8_14110 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) AHiyo8_14140 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase AHiyo8_14170 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AHiyo8_14180 ENOG4105CJ1 ABC, transporter AHiyo8_14230 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AHiyo8_14240 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AHiyo8_14250 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AHiyo8_14270 ENOG4105DZP Membrane-associated zinc metalloprotease AHiyo8_14280 ENOG4105DZP Membrane-associated zinc metalloprotease AHiyo8_14290 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AHiyo8_14300 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AHiyo8_14390 ENOG4105C1G acyl-Coa dehydrogenase AHiyo8_14400 ENOG4105C1G acyl-Coa dehydrogenase AHiyo8_14450 ENOG4107QX3 carboxylase AHiyo8_14480 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 AHiyo8_14490 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 AHiyo8_14500 ENOG4105CPP Dehydrogenase, E1 component AHiyo8_14520 ENOG4108YXU transcriptional regulator AsnC family AHiyo8_14560 ENOG4107QN1 sodium solute AHiyo8_14570 ENOG4107QN1 sodium solute AHiyo8_14580 ENOG4108HRK Histidine kinase AHiyo8_14590 ENOG4108NEV two component transcriptional regulator, LytTR family AHiyo8_14650 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AHiyo8_14660 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AHiyo8_14670 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AHiyo8_14680 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AHiyo8_14690 ENOG4105CE9 30S ribosomal protein S2 AHiyo8_14710 ENOG4105C1G acyl-Coa dehydrogenase AHiyo8_14780 ENOG4105F9F transposase AHiyo8_14790 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_14800 ENOG4105C2D reductase AHiyo8_14860 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AHiyo8_14940 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AHiyo8_14980 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AHiyo8_14990 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AHiyo8_15000 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AHiyo8_15010 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AHiyo8_15030 ENOG4108S01 response regulator AHiyo8_15040 ENOG4105KCT ABC transporter AHiyo8_15050 ENOG4108M15 ABC transporter AHiyo8_15110 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AHiyo8_15190 ENOG4105DWV Homoserine O-trans-acetylase AHiyo8_15200 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin AHiyo8_15270 ENOG4108IQK o-acetylhomoserine AHiyo8_15340 ENOG4105D2N Aldolase AHiyo8_15370 ENOG4105DKQ ROK family AHiyo8_15400 ENOG4105CI2 imidazolone-5-propionate hydrolase AHiyo8_15410 ENOG4105CI2 imidazolone-5-propionate hydrolase AHiyo8_15450 ENOG4105F8D glycoside hydrolase family 4 AHiyo8_15460 ENOG4105F8D glycoside hydrolase family 4 AHiyo8_15480 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AHiyo8_15490 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AHiyo8_15500 ENOG4105CPQ Dehydrogenase AHiyo8_15510 ENOG4105CPQ Dehydrogenase AHiyo8_15590 ENOG4105DRS transport system, permease AHiyo8_15600 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AHiyo8_15670 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AHiyo8_15680 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AHiyo8_15690 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AHiyo8_15710 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AHiyo8_15720 ENOG4105D4T Citrate transporter AHiyo8_15760 ENOG4105ES5 Histidine kinase AHiyo8_15780 ENOG4106YYS transcriptional regulatory protein AHiyo8_15800 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AHiyo8_15810 ENOG4105CPU Monooxygenase AHiyo8_15840 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AHiyo8_15850 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AHiyo8_15880 ENOG4108ZF3 Phosphatase AHiyo8_15910 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AHiyo8_15930 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AHiyo8_15950 ENOG4105D8K carboxyl transferase AHiyo8_15970 ENOG4108ETY sodium dicarboxylate symporter AHiyo8_15980 ENOG41082VC UPF0145 protein AHiyo8_16010 ENOG4105EYF MMPL domain protein AHiyo8_16020 ENOG4105EYF MMPL domain protein AHiyo8_16030 ENOG4107WR6 Maf-like protein AHiyo8_16040 ENOG4108JIK carboxylase AHiyo8_16050 ENOG4108JIK carboxylase AHiyo8_16060 ENOG4105CSH Transporter AHiyo8_16080 ENOG4107QND Nitrite extrusion protein AHiyo8_16120 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AHiyo8_16260 ENOG4105EDQ levansucrase EC 2.4.1.10 AHiyo8_16270 ENOG4108HKT sucrose-6-phosphate hydrolase AHiyo8_16300 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain AHiyo8_16310 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain AHiyo8_16370 ENOG4107QZF nitrite reductase NADPH large subunit AHiyo8_16380 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AHiyo8_16410 ENOG4107QNK )-transporter AHiyo8_16420 ENOG4107QNK )-transporter AHiyo8_16430 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_16450 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AHiyo8_16600 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AHiyo8_16630 ENOG4108UNV SUF system FeS assembly protein, NifU family AHiyo8_16660 ENOG4105C9B Cysteine desulfurase AHiyo8_16730 ENOG4107R8N Glycosyl transferase, family 2 AHiyo8_16780 ENOG4108NNZ chitinase AHiyo8_16800 ENOG4108IAJ Nad-dependent epimerase dehydratase AHiyo8_16810 ENOG4107QQG Dehydrogenase AHiyo8_16850 ENOG41086KC Transcriptional regulator AHiyo8_16950 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AHiyo8_16960 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AHiyo8_16970 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AHiyo8_16980 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AHiyo8_16990 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AHiyo8_17000 ENOG4108RZE Tetr family transcriptional regulator AHiyo8_17020 ENOG4105C5H ABC transporter AHiyo8_17030 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AHiyo8_17040 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AHiyo8_17050 ENOG4106839 domain protein AHiyo8_17060 ENOG4105F8V Hydrolase, tatD family AHiyo8_17070 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AHiyo8_17100 ENOG4105F8C transglutaminase domain-containing protein AHiyo8_17250 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) AHiyo8_17340 ENOG4107RGC Glycosyl transferase, family 2 AHiyo8_17350 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) AHiyo8_17420 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AHiyo8_17430 ENOG4105EIP mannose-6-phosphate isomerase AHiyo8_17450 ENOG4105F9F transposase AHiyo8_17470 ENOG4105F9F transposase AHiyo8_17510 ENOG4108V9Q carbonic anhydrase AHiyo8_17520 ENOG4105C9Q fumarate hydratase class II AHiyo8_17530 ENOG4105C9Q fumarate hydratase class II AHiyo8_17550 ENOG4105C0R drug resistance transporter emrb qaca subfamily AHiyo8_17650 ENOG4108IAB Phoh family AHiyo8_17660 ENOG4108IAB Phoh family AHiyo8_17670 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AHiyo8_17720 ENOG4105C7Z Conserved Protein AHiyo8_17740 ENOG4105T1M mycothiol conjugate amidase mca AHiyo8_17750 ENOG4105T1M mycothiol conjugate amidase mca AHiyo8_17770 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AHiyo8_17780 ENOG4105C7B Threonine dehydratase AHiyo8_17790 ENOG4105C7B Threonine dehydratase AHiyo8_17820 ENOG4107WI4 Aldose-1-epimerase AHiyo8_17840 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AHiyo8_17850 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AHiyo8_17870 ENOG4105CHU acetyl-coa acetyltransferase AHiyo8_17880 ENOG4105CHU acetyl-coa acetyltransferase AHiyo8_17890 ENOG4105CHU acetyl-coa acetyltransferase AHiyo8_17920 ENOG4108IV0 ABC, transporter AHiyo8_17930 ENOG4108IV0 ABC, transporter AHiyo8_17940 ENOG4105C0Z ABC transporter AHiyo8_17950 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AHiyo8_17960 ENOG4105C32 Amino acid ABC transporter (Permease) AHiyo8_17970 ENOG4105CP9 extracellular ligand-binding receptor AHiyo8_18050 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AHiyo8_18060 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AHiyo8_18080 ENOG4108IY2 MazG family AHiyo8_18090 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AHiyo8_18100 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN AHiyo8_18110 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN AHiyo8_18160 ENOG4105UIB (ABC) transporter AHiyo8_18200 ENOG4108JQ9 ABC transporter AHiyo8_18210 ENOG4108JQ9 ABC transporter AHiyo8_18230 ENOG4105DIH basic membrane AHiyo8_18240 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AHiyo8_18250 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AHiyo8_18260 ENOG4108ZHJ Organic hydroperoxide resistance protein AHiyo8_18270 ENOG4105K56 Transcriptional regulator AHiyo8_18280 ENOG4107RM1 amidohydrolase AHiyo8_18290 ENOG4107RM1 amidohydrolase AHiyo8_18300 ENOG4105CJT Mannose-1-phosphate guanylyltransferase AHiyo8_18340 ENOG4105E33 succinate dehydrogenase AHiyo8_18400 ENOG4105C31 Tryptophanyl-tRNA synthetase AHiyo8_18450 ENOG4105CJ1 ABC, transporter AHiyo8_18470 ENOG4105WH1 Two component transcriptional regulator luxr family AHiyo8_18480 ENOG4105BZU Histidine kinase AHiyo8_18490 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AHiyo8_18500 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AHiyo8_18510 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AHiyo8_18560 ENOG4108Z0R Transferase AHiyo8_18590 ENOG4105CUB amino acid AHiyo8_18600 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AHiyo8_18640 ENOG4105CJ1 ABC, transporter AHiyo8_18700 ENOG4105E2R ROK family AHiyo8_18740 ENOG4105C2J ABC transporter AHiyo8_18750 ENOG4105C2J ABC transporter AHiyo8_18760 ENOG4107RNG ABC transporter AHiyo8_18770 ENOG4105CNN ABC, transporter AHiyo8_18780 ENOG4105DFW ABC transporter AHiyo8_18790 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AHiyo8_18800 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AHiyo8_18810 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AHiyo8_18870 ENOG4107Y3Y amidohydrolase AHiyo8_18940 ENOG4105E9K Isocitrate dehydrogenase AHiyo8_18980 ENOG4105DC1 bifunctional purine biosynthesis protein purh AHiyo8_19010 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AHiyo8_19100 ENOG4105ERH Fumarylacetoacetate hydrolase AHiyo8_19120 ENOG4105ERH Fumarylacetoacetate hydrolase AHiyo8_19180 ENOG4105D2S major facilitator superfamily AHiyo8_19210 ENOG4105DZ6 Band 7 protein AHiyo8_19260 ENOG4105C6Y Udp-glucose 6-dehydrogenase AHiyo8_19270 ENOG4105C6Y Udp-glucose 6-dehydrogenase AHiyo8_19350 ENOG4105D7T ABC transporter AHiyo8_19410 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AHiyo8_19460 ENOG4105DDN Pentapeptide repeat-containing protein AHiyo8_19620 ENOG4105C54 Major Facilitator superfamily AHiyo8_19640 ENOG4105C54 Major Facilitator superfamily AHiyo8_19650 ENOG4105GRZ Ycii-related protein AHiyo8_19670 ENOG4105CHP RNA polymerase AHiyo8_19700 ENOG41061CK Antibiotic biosynthesis monooxygenase AHiyo8_19770 ENOG4105C2C drug resistance transporter, Bcr CflA AHiyo8_20000 ENOG4105CPC Aldo Keto reductase AHiyo8_20060 ENOG4108MRH transcriptional regulatory protein AHiyo8_20080 ENOG4108RR8 protoporphyrinogen oxidase AHiyo8_20110 ENOG4105C0X amino acid AHiyo8_20220 ENOG41080V3 Major Facilitator superfamily AHiyo8_20240 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AHiyo8_20300 ENOG4105NPE arsR family transcriptional regulator AHiyo8_20460 ENOG4105D2S major facilitator superfamily AHiyo8_20480 ENOG4105BZM domain protein AHiyo8_20490 ENOG4105BZM domain protein AHiyo8_20550 ENOG4105CNN ABC, transporter AHiyo8_20560 ENOG4107RNG ABC transporter AHiyo8_20580 ENOG4105DFW ABC transporter AHiyo8_20590 ENOG4105DFW ABC transporter AHiyo8_20660 ENOG4105CP7 Triose-phosphate isomerase AHiyo8_20730 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AHiyo8_20750 ENOG4107YVI ribose 5-phosphate isomerase AHiyo8_20760 ENOG4105CMT Dihydroxyacetone kinase AHiyo8_20810 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AHiyo8_20870 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AHiyo8_20890 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AHiyo8_20910 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AHiyo8_20920 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AHiyo8_21010 ENOG41076QQ Glycosyl transferase, family 2 AHiyo8_21050 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 AHiyo8_21090 ENOG4107HQ7 repeat protein AHiyo8_21100 ENOG4106N3A copper homeostasis protein cutc AHiyo8_21170 ENOG4105C0R drug resistance transporter emrb qaca subfamily AHiyo8_21180 ENOG4107UWP Major facilitator superfamily MFS_1 AHiyo8_21200 ENOG4105C7K acetolactate synthase AHiyo8_21290 ENOG4108JCI Transcriptional regulator AHiyo8_21460 ENOG4105EJQ L-serine dehydratase AHiyo8_21470 ENOG4105EJQ L-serine dehydratase AHiyo8_21530 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AHiyo8_21540 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AHiyo8_21660 ENOG4105DVW rieske (2Fe-2S) AHiyo8_21680 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase AHiyo8_21730 ENOG4105C26 Dehydrogenase AHiyo8_21740 ENOG4105C26 Dehydrogenase AHiyo8_21750 ENOG4108IJ7 Glycine betaine AHiyo8_21760 ENOG4107SQ8 Glycine betaine AHiyo8_21770 ENOG4108HQS Glycine betaine AHiyo8_21800 ENOG4105CSH Transporter AHiyo8_21810 ENOG4105CSH Transporter AHiyo8_21870 ENOG4108Z86 Glutamine amidotransferase AHiyo8_21900 ENOG4108X79 transcriptional regulator AHiyo8_21920 ENOG4105DH8 myo-inositol catabolism AHiyo8_21930 ENOG4105CK5 oxidoreductase AHiyo8_21940 ENOG4107TTA Xylose isomerase domain protein TIM barrel AHiyo8_21960 ENOG4105CK5 oxidoreductase AHiyo8_21980 ENOG4105CK5 oxidoreductase AHiyo8_21990 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AHiyo8_22000 ENOG4105C2J ABC transporter AHiyo8_22010 ENOG41062B0 ABC transporter, permease AHiyo8_22040 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_22110 ENOG4105CHH sulfate transporter AHiyo8_22120 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AHiyo8_22130 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AHiyo8_22150 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AHiyo8_22160 ENOG4105C26 Dehydrogenase AHiyo8_22170 ENOG4105C26 Dehydrogenase AHiyo8_22200 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) AHiyo8_22260 ENOG4105CMV Succinyl-CoA synthetase subunit beta AHiyo8_22320 ENOG4107TK4 histidinol-phosphate phosphatase AHiyo8_22370 ENOG4105BZU Histidine kinase AHiyo8_22490 ENOG4105BZU Histidine kinase AHiyo8_22500 ENOG4105BZU Histidine kinase AHiyo8_22510 ENOG4105BZU Histidine kinase AHiyo8_22520 ENOG4105BZU Histidine kinase AHiyo8_22530 ENOG4105BZ1 (ABC) transporter AHiyo8_22590 ENOG4105DRP amino acid AbC transporter AHiyo8_22600 ENOG4105CDA abc transporter atp-binding protein AHiyo8_22640 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AHiyo8_22730 ENOG41080QG Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AHiyo8_22790 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AHiyo8_22820 ENOG4107SFI Major Facilitator superfamily AHiyo8_22850 ENOG4105VEQ Cold shock protein AHiyo8_22920 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) AHiyo8_22940 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AHiyo8_22950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AHiyo8_22960 ENOG4105BZU Histidine kinase AHiyo8_22990 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AHiyo8_23040 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AHiyo8_23050 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AHiyo8_23130 ENOG4105EJQ L-serine dehydratase AHiyo8_23140 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AHiyo8_23160 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AHiyo8_23180 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AHiyo8_23190 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AHiyo8_23200 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AHiyo8_23230 ENOG4105C57 major facilitator superfamily AHiyo8_23250 ENOG4105C57 major facilitator superfamily AHiyo8_23280 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AHiyo8_23310 ENOG4105D7B Flagellar biosynthesis protein flha AHiyo8_23330 ENOG4105D00 flagellar biosynthetic protein flhB AHiyo8_23360 ENOG4105VS8 Flagellar biosynthetic protein fliq AHiyo8_23370 ENOG4105CN7 Flagellar biosynthetic protein FliP AHiyo8_23390 ENOG4105DD5 Flagellar motor switch protein AHiyo8_23470 ENOG4105X1Q TOBE domain protein AHiyo8_23500 ENOG4105ER2 Ompa motb domain protein AHiyo8_23510 ENOG4105E14 MotA TolQ exbB proton channel AHiyo8_23600 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AHiyo8_23700 ENOG4105US7 Histidine kinase AHiyo8_23710 ENOG4105XJC Two component transcriptional regulator (Winged helix family AHiyo8_23740 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AHiyo8_23820 ENOG4105ETS cytosine purines uracil thiamine allantoin AHiyo8_23830 ENOG4105ETS cytosine purines uracil thiamine allantoin AHiyo8_23850 ENOG4105CUB amino acid AHiyo8_23870 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AHiyo8_23890 ENOG4105ETS cytosine purines uracil thiamine allantoin AHiyo8_23900 ENOG4105ETS cytosine purines uracil thiamine allantoin AHiyo8_24010 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase AHiyo8_24060 ENOG4108JQA flagellar AHiyo8_24100 ENOG4105BZE flagellar hook protein, FlgE AHiyo8_24110 ENOG4105W00 Flagellar hook capping protein AHiyo8_24210 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AHiyo8_24220 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AHiyo8_24230 ENOG41084Q6 flagellar hook-basal body complex protein fliE AHiyo8_24240 ENOG4108ZC9 flagellar basal-body rod protein flgc AHiyo8_24250 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AHiyo8_24300 ENOG4105I03 Flagellin AHiyo8_24350 ENOG4105I03 Flagellin AHiyo8_24360 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) AHiyo8_24370 ENOG4105D5Q Arginine ornithine antiporter AHiyo8_24450 ENOG4105ECY inositol monophosphatase AHiyo8_24460 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AHiyo8_24470 ENOG4105E2Y ABC, transporter AHiyo8_24480 ENOG4105D38 putrescine abc transporter AHiyo8_24540 ENOG4105NPE arsR family transcriptional regulator AHiyo8_24580 ENOG4108MRH transcriptional regulatory protein AHiyo8_24590 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AHiyo8_24600 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AHiyo8_24610 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AHiyo8_24630 ENOG4105CD3 dihydroorotase AHiyo8_24750 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AHiyo8_24770 ENOG4107QSI ABC, transporter AHiyo8_24820 ENOG4108JQ7 (ABC) transporter AHiyo8_24850 ENOG4105CM2 brancheD-chain amino acid aminotransferase AHiyo8_24880 ENOG4105CD3 dihydroorotase AHiyo8_24890 ENOG4105CD3 dihydroorotase AHiyo8_24900 ENOG4105CPC Aldo Keto reductase AHiyo8_24910 ENOG4105CPC Aldo Keto reductase AHiyo8_24990 ENOG4105CH2 amidohydrolase AHiyo8_25030 ENOG410841Q phosphoesterase PA-phosphatase related protein AHiyo8_25080 ENOG41068WN AHiyo8_25120 ENOG410836F Transposase AHiyo8_25160 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AHiyo8_25230 ENOG410834F Transcriptional regulator AHiyo8_25260 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AHiyo8_25270 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AHiyo8_25280 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AHiyo8_25390 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) AHiyo8_25430 ENOG4105BZ4 penicillin-binding protein AHiyo8_25440 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AHiyo8_25470 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AHiyo8_25550 ENOG4107R08 Integrase AHiyo8_25590 ENOG4108IJ9 (ABC) transporter AHiyo8_25600 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AHiyo8_25640 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AHiyo8_25680 ENOG4105C3U ABC transporter AHiyo8_25690 ENOG4108JQ7 (ABC) transporter AHiyo8_25700 ENOG4105DZC cytosine deaminase AHiyo8_25740 ENOG4105CQB FAD linked oxidase domain protein AHiyo8_25750 ENOG4105CQB FAD linked oxidase domain protein AHiyo8_25790 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AHiyo8_25800 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AHiyo8_25810 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) AHiyo8_25850 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) AHiyo8_25860 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) AHiyo8_25870 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) AHiyo8_25960 ENOG4105C2N RNA methyltransferase TrmH family group 3 AHiyo8_25970 ENOG4105C8N cysteinyl-tRNA synthetase AHiyo8_25980 ENOG4105C8N cysteinyl-tRNA synthetase AHiyo8_25990 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AHiyo8_26000 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AHiyo8_26050 ENOG4105DQ6 Transposase AHiyo8_26080 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AHiyo8_26130 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AHiyo8_26140 ENOG4105C6E dna polymerase iii AHiyo8_26170 ENOG4106JDR secreted AHiyo8_26180 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AHiyo8_26340 ENOG4108J08 Csbd family AHiyo8_26370 ENOG4105CV8 reductase AHiyo8_26430 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AHiyo8_26490 ENOG4107QZF nitrite reductase NADPH large subunit AHiyo8_26500 ENOG4107QZF nitrite reductase NADPH large subunit AHiyo8_26510 ENOG4105EYW Ion transport protein AHiyo8_26520 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AHiyo8_26530 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AHiyo8_26580 ENOG4108IE3 prolyl oligopeptidase AHiyo8_26630 ENOG4105C0R drug resistance transporter emrb qaca subfamily AHiyo8_26640 ENOG4105C0R drug resistance transporter emrb qaca subfamily AHiyo8_26660 ENOG4105C9U ATP-dependent DNA helicase RecQ AHiyo8_26680 ENOG4107QKV phosphomannomutase AHiyo8_26760 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AHiyo8_26770 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) AHiyo8_26780 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) AHiyo8_26810 ENOG4105FDP GntR family transcriptional regulator AHiyo8_26840 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AHiyo8_26850 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AHiyo8_26870 ENOG4108JQ7 (ABC) transporter AHiyo8_26920 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) AHiyo8_26970 ENOG4105ECB domain protein AHiyo8_26980 ENOG4108IG5 Transcriptional regulator AHiyo8_27020 ENOG4108594 Permease of the drug metabolite transporter AHiyo8_27030 ENOG4105DUM transcriptional regulator, lysR family AHiyo8_27100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AHiyo8_27110 ENOG4105BZU Histidine kinase AHiyo8_27120 ENOG4105BZU Histidine kinase AHiyo8_27180 ENOG4105EDW glycosyl transferase, family 39 AHiyo8_27220 ENOG4105EDW glycosyl transferase, family 39 AHiyo8_27240 ENOG4105EDW glycosyl transferase, family 39 AHiyo8_27300 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AHiyo8_27310 ENOG4108SU4 UPF0309 protein AHiyo8_27320 ENOG4105CE4 GlcNAc 6-P deacetylase AHiyo8_27340 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_27380 ENOG4105C0R drug resistance transporter emrb qaca subfamily AHiyo8_27390 ENOG4105C57 major facilitator superfamily AHiyo8_27410 ENOG4108IG5 Transcriptional regulator AHiyo8_27430 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AHiyo8_27440 ENOG4108Z6B deaminase AHiyo8_27460 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 AHiyo8_27550 ENOG4108HKT sucrose-6-phosphate hydrolase AHiyo8_27560 ENOG4108HKT sucrose-6-phosphate hydrolase AHiyo8_27630 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AHiyo8_27650 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AHiyo8_27780 ENOG4105K56 Transcriptional regulator AHiyo8_27790 ENOG410836F Transposase AHiyo8_27880 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AHiyo8_27940 ENOG4108QMY dioxygenase AHiyo8_27950 ENOG4105NN7 muconolactone delta-isomerase AHiyo8_27970 ENOG4107S8C mandelate racemase muconate lactonizing AHiyo8_27990 ENOG4107RSM transcriptional regulator AHiyo8_28170 ENOG4107QRT dEAD DEAH box helicase AHiyo8_28180 ENOG4107QRT dEAD DEAH box helicase AHiyo8_28190 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) AHiyo8_28200 ENOG4108VW9 Membrane AHiyo8_28280 ENOG4108W1A pseudouridine synthase AHiyo8_28310 ENOG4108UVJ appr-1-p processing domain protein AHiyo8_28320 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN AHiyo8_28340 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AHiyo8_28350 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AHiyo8_28360 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AHiyo8_28370 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AHiyo8_28460 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_28470 ENOG4105CSH Transporter AHiyo8_28480 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) AHiyo8_28490 ENOG4105C1G acyl-Coa dehydrogenase AHiyo8_28590 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AHiyo8_28630 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AHiyo8_28720 ENOG4107R9S Malate synthase AHiyo8_28730 ENOG4107R9S Malate synthase AHiyo8_28740 ENOG4107R9S Malate synthase AHiyo8_28750 ENOG4107R9S Malate synthase AHiyo8_28870 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AHiyo8_28950 ENOG4108MR6 WD40-like Beta Propeller Repeat AHiyo8_28960 ENOG41090KN UPF0303 protein AHiyo8_28970 ENOG4105CSH Transporter AHiyo8_29000 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) AHiyo8_29140 ENOG4108V06 Glutathione peroxidase AHiyo8_29150 ENOG4105E4C Lytic transglycosylase catalytic AHiyo8_29210 ENOG4105C26 Dehydrogenase AHiyo8_29220 ENOG4105C26 Dehydrogenase AHiyo8_29260 ENOG4105EGD dinuclear metal center protein, YbgI family AHiyo8_29300 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AHiyo8_29340 ENOG4105CJ1 ABC, transporter AHiyo8_29350 ENOG4105CFH Aspartokinase AHiyo8_29390 ENOG4105K56 Transcriptional regulator AHiyo8_29460 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin AHiyo8_29500 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I AHiyo8_29510 ENOG4107QIK phosphoribosylformylglycinamidine synthase AHiyo8_29520 ENOG4107QIK phosphoribosylformylglycinamidine synthase AHiyo8_29630 ENOG4105MSB protein, conserved in bacteria AHiyo8_29660 ENOG4105K4P CoA-binding domain protein AHiyo8_29700 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AHiyo8_29730 ENOG4105HSS phospholipase C AHiyo8_29770 ENOG4108JEZ rRNA small subunit methyltransferase G AHiyo8_29810 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AHiyo8_29850 ENOG4105CK5 oxidoreductase AHiyo8_29860 ENOG4105D9R oxidoreductase AHiyo8_29880 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component AHiyo8_29920 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_29930 ENOG4107RA1 nh(3)-dependent nad( ) synthetase AHiyo8_29940 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AHiyo8_29960 ENOG4105KHC sulfurtransferase AHiyo8_29970 ENOG4105E39 Enoyl-CoA hydratase AHiyo8_30010 ENOG4105E39 Enoyl-CoA hydratase AHiyo8_30020 ENOG4105C26 Dehydrogenase AHiyo8_30030 ENOG4105C26 Dehydrogenase AHiyo8_30040 ENOG4105CVP deoxyribo-dipyrimidine photolyase AHiyo8_30050 ENOG4105CVP deoxyribo-dipyrimidine photolyase AHiyo8_30080 ENOG4105D6N CoA-transferase, subunit a AHiyo8_30150 ENOG4105WH1 Two component transcriptional regulator luxr family AHiyo8_30220 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_30280 ENOG4105CG3 alpha amylase, catalytic region AHiyo8_30290 ENOG4105CG3 alpha amylase, catalytic region AHiyo8_30300 ENOG4105CG3 alpha amylase, catalytic region AHiyo8_30370 ENOG4105VBF alkaline shock protein AHiyo8_30410 ENOG4105D7K pfkb domain protein AHiyo8_30420 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_30480 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AHiyo8_30540 ENOG4105C7N Xanthine uracil vitamin C permease AHiyo8_30550 ENOG4105C7N Xanthine uracil vitamin C permease AHiyo8_30560 ENOG4105C7N Xanthine uracil vitamin C permease AHiyo8_30570 ENOG41088SP formiminoglutamate hydrolase AHiyo8_30580 ENOG41088SP formiminoglutamate hydrolase AHiyo8_30590 ENOG41088SP formiminoglutamate hydrolase AHiyo8_30680 ENOG4105DSG hydrolase family 43 AHiyo8_30710 ENOG4107QK4 glycoside hydrolase, family 3 domain protein AHiyo8_30720 ENOG4107QK4 glycoside hydrolase, family 3 domain protein AHiyo8_30820 ENOG4105DEF Extracellular solute-binding protein, family 5 AHiyo8_30860 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AHiyo8_30900 ENOG4108NQD AHiyo8_30910 ENOG4105JXH GntR family transcriptional regulator AHiyo8_30930 ENOG4105CMT Dihydroxyacetone kinase AHiyo8_30940 ENOG4105CMT Dihydroxyacetone kinase AHiyo8_30950 ENOG4107YVI ribose 5-phosphate isomerase AHiyo8_30960 ENOG4105CP7 Triose-phosphate isomerase AHiyo8_30990 ENOG4108KFM Xylose Isomerase Domain-Containing protein AHiyo8_31000 ENOG4106J7G oxidoreductase AHiyo8_31010 ENOG4105C7I Dehydrogenase AHiyo8_31020 ENOG4105C7I Dehydrogenase AHiyo8_31030 ENOG4105C7I Dehydrogenase AHiyo8_31060 ENOG4105C84 Histidine ammonia-lyase AHiyo8_31070 ENOG4105C84 Histidine ammonia-lyase AHiyo8_31080 ENOG4105C84 Histidine ammonia-lyase AHiyo8_31090 ENOG4105CGP Urocanate hydratase AHiyo8_31120 ENOG4105CGP Urocanate hydratase AHiyo8_31140 ENOG4105C85 amino acid AHiyo8_31150 ENOG4105C85 amino acid AHiyo8_31160 ENOG4105C85 amino acid AHiyo8_31170 ENOG4105C85 amino acid AHiyo8_31180 ENOG410829K Lysine exporter protein (Lyse ygga) AHiyo8_31220 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_31230 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component AHiyo8_31260 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component AHiyo8_31310 ENOG4105BZU Histidine kinase AHiyo8_31390 ENOG4107ZBN O-methyltransferase AHiyo8_31480 ENOG4106BRA Membrane AHiyo8_31500 ENOG4105P4J Allophanate hydrolase, subunit 1 AHiyo8_31560 ENOG41087PP glycosyltransferase MGT family AHiyo8_31630 ENOG4107UVD Beta-phosphoglucomutase family hydrolase AHiyo8_31670 ENOG4105CPN adenine deaminase AHiyo8_31740 ENOG4105CNN ABC, transporter AHiyo8_31750 ENOG4105C2J ABC transporter AHiyo8_31850 ENOG4105E98 transcriptional regulator DeoR family AHiyo8_31860 ENOG4105E98 transcriptional regulator DeoR family AHiyo8_31910 ENOG4105DM4 PTS System AHiyo8_31920 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AHiyo8_31930 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AHiyo8_31940 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AHiyo8_31950 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AHiyo8_32000 ENOG41067RQ csbd family AHiyo8_32020 ENOG4105FDF Could be involved in DNA repair (By similarity) AHiyo8_32080 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AHiyo8_32090 ENOG4105CSH Transporter AHiyo8_32100 ENOG4105CSH Transporter AHiyo8_32110 ENOG4105CSH Transporter AHiyo8_32130 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AHiyo8_32140 ENOG4105BZU Histidine kinase AHiyo8_32150 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase AHiyo8_32220 ENOG4105EXC Acyl-transferase AHiyo8_32230 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AHiyo8_32240 ENOG4105XYF acetyltransferase AHiyo8_32300 ENOG4105EMU Dehydrogenase AHiyo8_32440 ENOG4105CXN decarboxylase AHiyo8_32470 ENOG4105C6Z Gluconate AHiyo8_32480 ENOG4105ZXK Dehydrogenase AHiyo8_32490 ENOG4105ZXK Dehydrogenase AHiyo8_32520 ENOG4107EJG GntR family transcriptional regulator AHiyo8_32540 ENOG4107QK5 Homocysteine s-methyltransferase AHiyo8_32620 ENOG4108IQI permease AHiyo8_32630 ENOG4108IQI permease AHiyo8_32660 ENOG4108IJ0 Aspartate ammonia-lyase AHiyo8_32670 ENOG4105EW9 transcriptional regulator AsnC family AHiyo8_32690 ENOG4105WKW Pfam:DUF1458 AHiyo8_32730 ENOG4105CV8 reductase AHiyo8_32740 ENOG4105CPC Aldo Keto reductase AHiyo8_32760 ENOG4105CV8 reductase AHiyo8_32820 ENOG4105DCG PHP domain protein AHiyo8_32830 ENOG4105D9G High-affinity AHiyo8_32840 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AHiyo8_32850 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) AHiyo8_32860 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AHiyo8_32870 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) AHiyo8_32880 ENOG4105CQM Urea amidohydrolase subunit alpha AHiyo8_32890 ENOG4105CQM Urea amidohydrolase subunit alpha AHiyo8_32900 ENOG4105CQM Urea amidohydrolase subunit alpha AHiyo8_32910 ENOG4105CQM Urea amidohydrolase subunit alpha AHiyo8_32920 ENOG4105KI2 Urea amidohydrolase subunit beta AHiyo8_32930 ENOG4108YZ9 Urea amidohydrolase subunit gamma AHiyo8_32940 ENOG4106W5V Membrane AHiyo8_32950 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F AHiyo8_32990 ENOG4107QXV Phosphate transporter AHiyo8_33000 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AHiyo8_33010 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AHiyo8_33040 ENOG4105C8U phosphate abc transporter AHiyo8_33100 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AHiyo8_33110 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) AHiyo8_33150 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AHiyo8_33190 ENOG4108UTZ Dihydroxyacetone kinase AHiyo8_33210 ENOG4105CMT Dihydroxyacetone kinase AHiyo8_33220 ENOG4105CMT Dihydroxyacetone kinase AHiyo8_33250 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AHiyo8_33260 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AHiyo8_33270 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AHiyo8_33290 ENOG4105CRK lysyL-tRNA synthetase AHiyo8_33300 ENOG4108YIQ Alpha beta hydrolase AHiyo8_33330 ENOG4105C1G acyl-Coa dehydrogenase AHiyo8_33370 ENOG4105C0R drug resistance transporter emrb qaca subfamily AHiyo8_33380 ENOG4105C0R drug resistance transporter emrb qaca subfamily AHiyo8_33390 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AHiyo8_33400 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AHiyo8_33450 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AHiyo8_33480 ENOG4105EUJ GTP cyclohydrolase i AHiyo8_33490 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AHiyo8_33510 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AHiyo8_33590 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AHiyo8_33710 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AHiyo8_33720 ENOG4107TE5 Lipid kinase AHiyo8_33750 ENOG4105VFE sira family AHiyo8_33760 ENOG4105EC3 peptidase S51, dipeptidase E AHiyo8_33770 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AHiyo8_33810 ENOG4105DUX Transporter AHiyo8_33860 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) AHiyo8_33870 ENOG4105C2W permease AHiyo8_33890 ENOG4105BZW Glycerate kinase AHiyo8_33910 ENOG4105CHP RNA polymerase AHiyo8_33970 ENOG41086KC Transcriptional regulator AHiyo8_33980 ENOG4108K4B hydrolase AHiyo8_34050 ENOG4105CHH sulfate transporter AHiyo8_34060 ENOG4105CHH sulfate transporter AHiyo8_34070 ENOG4105C09 Bile acid AHiyo8_34090 ENOG4105C09 Bile acid AHiyo8_34100 ENOG4107P2S Transcriptional regulator AHiyo8_34300 ENOG4105CH7 arginosuccinase AHiyo8_34320 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_34330 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_34350 ENOG4108JIK carboxylase AHiyo8_34360 ENOG4108JIK carboxylase AHiyo8_34370 ENOG4107R7A Allophanate hydrolase subunit 2 AHiyo8_34380 ENOG4107R7A Allophanate hydrolase subunit 2 AHiyo8_34400 ENOG4105E7W lamb ycsf family protein AHiyo8_34490 ENOG4105HZM Fha domain containing protein AHiyo8_34510 ENOG4108ZF3 Phosphatase AHiyo8_34530 ENOG4107QHZ cell cycle protein AHiyo8_34560 ENOG4105CJN penicillin-binding protein AHiyo8_34580 ENOG4107TPY serine threonine protein kinase AHiyo8_34610 ENOG4105D9P serine threonine protein kinase AHiyo8_34660 ENOG4105ZJT Cell division protein CrgA AHiyo8_34670 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AHiyo8_34680 ENOG4105K6V RNA polymerase AHiyo8_34690 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AHiyo8_34700 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AHiyo8_34710 ENOG4105CF1 Alkylated DNA repair protein AHiyo8_34720 ENOG4108R3E Dna-3-methyladenine glycosylase i AHiyo8_34830 ENOG4105CND Glycosyl transferase, family 2 AHiyo8_34860 ENOG4108ZED Transmembrane domain of unknown function (DUF3566) AHiyo8_34870 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AHiyo8_34880 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AHiyo8_34890 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AHiyo8_34900 ENOG4105K7N UPF0232 protein AHiyo8_34920 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AHiyo8_34930 ENOG4108J5G 6-phosphogluconate dehydrogenase AHiyo8_34950 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AHiyo8_34960 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AHiyo8_34970 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AHiyo8_34990 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AHiyo8_35000 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AHiyo8_35020 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AHiyo8_35030 ENOG4107QJE Chromosome Partitioning Protein AHiyo8_35050 ENOG4105K63 Thioredoxin AHiyo8_35060 ENOG4105C3M thioredoxin reductase AHiyo8_35120 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AHiyo8_35130 ENOG4108ZM9 phosphoglycerate mutase AHiyo8_35190 ENOG4108RYK Nad-dependent epimerase dehydratase AHiyo8_35200 ENOG4105KVH Transcriptional regulator AHiyo8_35220 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AHiyo8_35240 ENOG4108ZGX Histidine kinase AHiyo8_35250 ENOG4105WH1 Two component transcriptional regulator luxr family AHiyo8_35270 ENOG4105CJN penicillin-binding protein AHiyo8_35310 ENOG4108IG5 Transcriptional regulator AHiyo8_35320 ENOG4105C5H ABC transporter AHiyo8_35350 ENOG4106UW1 Major Facilitator superfamily AHiyo8_35380 ENOG4107RBB ABC transporter, permease AHiyo8_35390 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AHiyo8_35470 ENOG4105CJ1 ABC, transporter AHiyo8_35480 ENOG4105CJ1 ABC, transporter AHiyo8_35520 ENOG4105BZU Histidine kinase AHiyo8_35530 ENOG4105WH1 Two component transcriptional regulator luxr family AHiyo8_35540 ENOG4105DFM M18 family aminopeptidase AHiyo8_35570 ENOG4105KK4 UPF0060 membrane protein AHiyo8_35580 ENOG4105KK4 UPF0060 membrane protein AHiyo8_35590 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) AHiyo8_35620 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AHiyo8_35630 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AHiyo8_35660 ENOG4108UZX fmn reductase AHiyo8_35690 ENOG4105CDU Replicative dna helicase AHiyo8_35700 ENOG4105CDU Replicative dna helicase AHiyo8_35740 ENOG4105NQG DoxX AHiyo8_35830 ENOG4105C59 p-type ATPase AHiyo8_35890 ENOG4105VPX protein, conserved in bacteria AHiyo8_35940 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component AHiyo8_35960 ENOG4105E2D ec 3.2.1.52 AHiyo8_35970 ENOG4107HP6 Transcriptional regulator AHiyo8_35980 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AHiyo8_36010 ENOG4105KME endoribonuclease L-psp AHiyo8_36030 ENOG4105J4Q Transcriptional regulator AHiyo8_36080 ENOG4105C6Z Gluconate AHiyo8_36090 ENOG4105C6Z Gluconate AHiyo8_36150 ENOG4105CSH Transporter AHiyo8_36160 ENOG4105J4Q Transcriptional regulator AHiyo8_36170 ENOG4107S9B Shikimate dehydrogenase AHiyo8_36180 ENOG4107S9B Shikimate dehydrogenase AHiyo8_36230 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase AHiyo8_36250 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase AHiyo8_36260 ENOG4105CHU acetyl-coa acetyltransferase AHiyo8_36270 ENOG4107QP7 CoA-transferase subunit A AHiyo8_36280 ENOG4107QNJ CoA-transferase subunit B AHiyo8_36310 ENOG4107HP6 Transcriptional regulator AHiyo8_36370 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AHiyo8_36390 ENOG4105W8H transhydrogenase (subunit alpha AHiyo8_36400 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AHiyo8_36500 ENOG4105VEQ Cold shock protein AHiyo8_36620 ENOG4105C3J Cysteine desulfurase AHiyo8_36630 ENOG41062BK proline dehydrogenase AHiyo8_36660 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AHiyo8_36710 ENOG41069M3 Transcriptional regulator AHiyo8_36740 ENOG4107WI4 Aldose-1-epimerase AHiyo8_36750 ENOG4105DKQ ROK family AHiyo8_36760 ENOG4105QE3 oxidoreductase AHiyo8_36770 ENOG4105QE3 oxidoreductase AHiyo8_36780 ENOG4105C93 Xylose Isomerase AHiyo8_36840 ENOG4105DKQ ROK family AHiyo8_36940 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component AHiyo8_36960 ENOG4105XN3 extracellular solute-binding protein family 1 AHiyo8_36970 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_37060 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AHiyo8_37070 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AHiyo8_37080 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AHiyo8_37090 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AHiyo8_37100 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AHiyo8_37110 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) AHiyo8_37200 ENOG4105BZ1 (ABC) transporter AHiyo8_37210 ENOG4105BZ1 (ABC) transporter AHiyo8_37220 ENOG4105BZ1 (ABC) transporter AHiyo8_37330 ENOG4105QPS Monooxygenase AHiyo8_37370 ENOG4108WYP Transcriptional regulator AHiyo8_37450 ENOG4105CHM Aminotransferase AHiyo8_37460 ENOG4105JSC dimethylmenaquinone methyltransferase AHiyo8_37480 ENOG4106P55 Transcriptional regulator AHiyo8_37490 ENOG4105E7W lamb ycsf family protein AHiyo8_37500 ENOG4105P4J Allophanate hydrolase, subunit 1 AHiyo8_37550 ENOG4105CSH Transporter AHiyo8_37580 ENOG4105NAU thioesterase Superfamily protein AHiyo8_37630 ENOG4107QTF adenylosuccinate lyase AHiyo8_37660 ENOG4105CIH Imidazole acetol-phosphate transaminase AHiyo8_37690 ENOG4105CPP Dehydrogenase, E1 component AHiyo8_37700 ENOG4105CPP Dehydrogenase, E1 component AHiyo8_37710 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 AHiyo8_37760 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AHiyo8_37810 ENOG41082JN Transcriptional regulator AHiyo8_37820 ENOG4105D9R oxidoreductase AHiyo8_37830 ENOG4105D9R oxidoreductase AHiyo8_37880 ENOG4105DCF alanine dehydrogenase AHiyo8_37890 ENOG4105DCF alanine dehydrogenase AHiyo8_37930 ENOG4105H3G oxidoreductase AHiyo8_37980 ENOG4108IG5 Transcriptional regulator AHiyo8_38020 ENOG4105KRI phosphocarrier protein (HPr AHiyo8_38040 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AHiyo8_38060 ENOG4105CTS PTS system mannitol-specific AHiyo8_38070 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase AHiyo8_38080 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase AHiyo8_38120 ENOG4105C85 amino acid AHiyo8_38150 ENOG4105DXB Major Facilitator superfamily AHiyo8_38160 ENOG4105DXB Major Facilitator superfamily AHiyo8_38200 ENOG4105C0R drug resistance transporter emrb qaca subfamily AHiyo8_38220 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AHiyo8_38250 ENOG4108SGK Tetr family transcriptional regulator AHiyo8_38270 ENOG4105C6K Malic enzyme AHiyo8_38280 ENOG4108XG2 Histidine kinase AHiyo8_38290 ENOG4105WH1 Two component transcriptional regulator luxr family AHiyo8_38320 ENOG4105N14 lysine exporter protein LysE YggA AHiyo8_38330 ENOG4108XM1 transcriptional regulator AsnC family AHiyo8_38390 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) AHiyo8_38510 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AHiyo8_38520 ENOG4105CHR reductase AHiyo8_38540 ENOG4105DIA mandelate racemase muconate lactonizing AHiyo8_38550 ENOG4105DIA mandelate racemase muconate lactonizing AHiyo8_38570 ENOG4105CNN ABC, transporter AHiyo8_38600 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) AHiyo8_38630 ENOG4107YCY Transcriptional regulator AHiyo8_38650 ENOG4108IJ0 Aspartate ammonia-lyase AHiyo8_38690 ENOG4105KRQ Addiction module toxin, Txe YoeB family AHiyo8_38700 ENOG4105VTW prevent-host-death family AHiyo8_38780 ENOG4105CPC Aldo Keto reductase AHiyo8_38810 ENOG4105K5B UPF0225 protein AHiyo8_38930 ENOG4105DQ5 transport system permease protein AHiyo8_38940 ENOG4105E0A ABC, transporter AHiyo8_39040 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AHiyo8_39050 ENOG4105KDC 50s ribosomal protein l28 AHiyo8_39060 ENOG4105W0E 50S ribosomal protein L33 AHiyo8_39070 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AHiyo8_39080 ENOG4108426 dNA-binding protein AHiyo8_39150 ENOG4105D7A ATP-binding protein AHiyo8_39190 ENOG4105E5Q amino acid AbC transporter AHiyo8_39200 ENOG4105CDA abc transporter atp-binding protein AHiyo8_39290 ENOG4105C5H ABC transporter AHiyo8_39370 ENOG41068WN AHiyo8_39390 ENOG4105C5I Dehydrogenase AHiyo8_39430 ENOG4105DEN Luciferase family AHiyo8_39460 ENOG4105BZP glycoside hydrolase 15-related AHiyo8_39480 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AHiyo8_39490 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AHiyo8_39530 ENOG4106NZI LysR family Transcriptional regulator AHiyo8_39610 ENOG4105DHP deoxycytidine triphosphate deaminase AHiyo8_39620 ENOG4105DHP deoxycytidine triphosphate deaminase AHiyo8_39630 ENOG4107S91 Sodium hydrogen exchanger AHiyo8_39640 ENOG4107W2M Sodium hydrogen exchanger AHiyo8_39650 ENOG4105D0C transport protein AHiyo8_39660 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AHiyo8_39670 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) AHiyo8_39710 ENOG4105D65 subunit l AHiyo8_39720 ENOG4105D65 subunit l AHiyo8_39730 ENOG4108JPZ Monovalent cation H antiporter subunit D AHiyo8_39760 ENOG41080TA Multiple resistance and ph regulation protein f AHiyo8_39770 ENOG4105KJM monovalent cation h antiporter subunit g AHiyo8_39800 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein AHiyo8_39810 ENOG4108JJB ABC transporter AHiyo8_39820 ENOG4108JJB ABC transporter AHiyo8_39840 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AHiyo8_39870 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) AHiyo8_39880 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) AHiyo8_39890 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) AHiyo8_40090 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AHiyo8_40100 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AHiyo8_40120 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase AHiyo8_40160 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AHiyo8_40210 ENOG4105KJF protein tyrosine phosphatase AHiyo8_40220 ENOG4108RVA ribokinase AHiyo8_40240 ENOG4105DU0 nucleoside hydrolase AHiyo8_40250 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_40280 ENOG410829K Lysine exporter protein (Lyse ygga) AHiyo8_40320 ENOG4105CHP RNA polymerase AHiyo8_40330 ENOG4105GRZ Ycii-related protein AHiyo8_40340 ENOG41089UC methyltransferase, type 11 AHiyo8_40640 ENOG4105NX3 Membrane AHiyo8_40650 ENOG4105CFG Acts as a chaperone (By similarity) AHiyo8_40660 ENOG4105CFG Acts as a chaperone (By similarity) AHiyo8_40670 ENOG4105CFG Acts as a chaperone (By similarity) AHiyo8_40680 ENOG4105CFG Acts as a chaperone (By similarity) AHiyo8_40690 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AHiyo8_40700 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AHiyo8_40710 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AHiyo8_40720 ENOG4105KNI merR family transcriptional Regulator AHiyo8_40800 ENOG4105ERH Fumarylacetoacetate hydrolase AHiyo8_40810 ENOG4105KME endoribonuclease L-psp AHiyo8_40840 ENOG4105E5Q amino acid AbC transporter AHiyo8_40940 ENOG4108HW4 amino acid AbC transporter AHiyo8_40960 ENOG4105EAB amino acid AbC transporter AHiyo8_40980 ENOG4105C0D helicase AHiyo8_41080 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AHiyo8_41090 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AHiyo8_41100 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AHiyo8_41110 ENOG4105DJ2 Major Facilitator Superfamily AHiyo8_41150 ENOG4105CH2 amidohydrolase AHiyo8_41240 ENOG4105C1J atp-dependent rna helicase AHiyo8_41270 ENOG4108FN7 Aldo keto reductase AHiyo8_41280 ENOG4105CPC Aldo Keto reductase AHiyo8_41290 ENOG4105KPY Small multidrug resistance protein AHiyo8_41300 ENOG4105KPY Small multidrug resistance protein AHiyo8_41330 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase AHiyo8_41340 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase AHiyo8_41390 ENOG410901E Membrane AHiyo8_41410 ENOG4105C7K acetolactate synthase AHiyo8_41420 ENOG4105C7K acetolactate synthase AHiyo8_41570 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AHiyo8_41580 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AHiyo8_41650 ENOG4105DRP amino acid AbC transporter AHiyo8_41660 ENOG4105EAD ABC transporter AHiyo8_41670 ENOG4105E2Y ABC, transporter AHiyo8_41690 ENOG4107YCR Transcriptional regulator, ARSR family AHiyo8_41720 ENOG4105CXB phosphoribosylaminoimidazole synthetase AHiyo8_41780 ENOG4105C6F GntR Family Transcriptional Regulator AHiyo8_41790 ENOG4105C5F glutamine synthetase AHiyo8_41810 ENOG4108Z86 Glutamine amidotransferase AHiyo8_41840 ENOG4105C26 Dehydrogenase AHiyo8_41850 ENOG4105C26 Dehydrogenase AHiyo8_41880 ENOG4105VT2 5-hydroxyisourate hydrolase AHiyo8_41920 ENOG4105C5R Aminotransferase AHiyo8_41980 ENOG4105BZW Glycerate kinase AHiyo8_42000 ENOG41060W2 glyoxylate carboligase AHiyo8_42010 ENOG41060W2 glyoxylate carboligase AHiyo8_42030 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AHiyo8_42040 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AHiyo8_42120 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AHiyo8_42180 ENOG4107QJT sodium dicarboxylate symporter AHiyo8_42190 ENOG4105CK2 sodium dicarboxylate symporter AHiyo8_42210 ENOG4106P55 Transcriptional regulator AHiyo8_42230 ENOG4107QK5 Homocysteine s-methyltransferase AHiyo8_42390 ENOG4105C84 Histidine ammonia-lyase AHiyo8_42400 ENOG4105CGP Urocanate hydratase AHiyo8_42410 ENOG4105CGP Urocanate hydratase AHiyo8_42420 ENOG4105CGP Urocanate hydratase AHiyo8_42440 ENOG4105E90 ABC transporter AHiyo8_42470 ENOG4108IJ8 ABC transporter AHiyo8_42530 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AHiyo8_42670 ENOG4105RD7 BadF BadG BcrA BcrD AHiyo8_42770 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component AHiyo8_42800 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_42820 ENOG4105WBN Transcriptional regulator (LacI family AHiyo8_42840 ENOG4107YVI ribose 5-phosphate isomerase AHiyo8_42850 ENOG4105CMT Dihydroxyacetone kinase AHiyo8_42860 ENOG4105CMT Dihydroxyacetone kinase AHiyo8_42890 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AHiyo8_42900 ENOG4105CSH Transporter AHiyo8_42910 ENOG4105CSH Transporter AHiyo8_42960 ENOG4105NFY transcriptional modulator of maze toxin, mazf AHiyo8_43000 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AHiyo8_43080 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AHiyo8_43110 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AHiyo8_43120 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AHiyo8_43130 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AHiyo8_43160 ENOG4105CHR reductase AHiyo8_43400 ENOG4105BZ4 penicillin-binding protein AHiyo8_43420 ENOG4105C7B Threonine dehydratase AHiyo8_43430 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AHiyo8_43440 ENOG4105BZP glycoside hydrolase 15-related AHiyo8_43450 ENOG4105BZP glycoside hydrolase 15-related AHiyo8_43460 ENOG4105FF5 Membrane AHiyo8_43470 ENOG4105FF5 Membrane AHiyo8_43540 ENOG4105FQP Beta-lactamase AHiyo8_43550 ENOG4105S0E allantoin catabolism protein AHiyo8_43580 ENOG4107R9S Malate synthase AHiyo8_43610 ENOG41069M3 Transcriptional regulator AHiyo8_43620 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AHiyo8_43630 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AHiyo8_43660 ENOG4105C2W permease AHiyo8_43730 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AHiyo8_43740 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AHiyo8_43760 ENOG4105C7N Xanthine uracil vitamin C permease AHiyo8_43770 ENOG4105C7N Xanthine uracil vitamin C permease AHiyo8_43820 ENOG4108UTP (2Fe-2S)-binding domain protein AHiyo8_43840 ENOG4105C7W Xanthine dehydrogenase AHiyo8_43880 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AHiyo8_43890 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AHiyo8_43900 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AHiyo8_43930 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AHiyo8_43950 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AHiyo8_43980 ENOG4105CSV Glutaminase AHiyo8_44040 ENOG4105CXN decarboxylase AHiyo8_44050 ENOG4105CK2 sodium dicarboxylate symporter AHiyo8_44060 ENOG4105CK2 sodium dicarboxylate symporter AHiyo8_44130 ENOG4105C12 Phosphoribosylglycinamide synthetase AHiyo8_44140 ENOG4105C12 Phosphoribosylglycinamide synthetase AHiyo8_44150 ENOG4105C8V SAICAR synthetase AHiyo8_44180 ENOG4105BZ1 (ABC) transporter AHiyo8_44200 ENOG4105BZ1 (ABC) transporter AHiyo8_44210 ENOG4107RGJ metallophosphoesterase AHiyo8_44240 ENOG4105BZ4 penicillin-binding protein AHiyo8_44290 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AHiyo8_44330 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AHiyo8_44390 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_44400 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_44410 ENOG4105E98 transcriptional regulator DeoR family AHiyo8_44500 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AHiyo8_44510 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AHiyo8_44530 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AHiyo8_44710 ENOG4108I5C dEAD DEAH box helicase AHiyo8_44730 ENOG4105C72 UPF0176 protein AHiyo8_44760 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AHiyo8_44790 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AHiyo8_44800 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AHiyo8_44830 ENOG4107R33 ppx gppa phosphatase AHiyo8_44840 ENOG4105EY0 Xylose isomerase domain protein TIM barrel AHiyo8_44850 ENOG4105II7 pyrroline-5-carboxylate reductase AHiyo8_44860 ENOG4107ZYR domain protein AHiyo8_44890 ENOG4105DGU Histone deacetylase AHiyo8_44910 ENOG41082BM Transcriptional regulator, arsr family AHiyo8_44960 ENOG41060NJ transcriptional regulator AHiyo8_44970 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AHiyo8_45000 ENOG4108RXW HAD-superfamily subfamily IB hydrolase AHiyo8_45030 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) AHiyo8_45080 ENOG4108RH7 phosphoglycerate mutase AHiyo8_45090 ENOG4108RH7 phosphoglycerate mutase AHiyo8_45110 ENOG4107QIV Cytochrome c biogenesis protein AHiyo8_45150 ENOG4105CRE cytochrome C AHiyo8_45210 ENOG4107SIQ Naphthoate synthase AHiyo8_45250 ENOG4108TYN CAAX amino terminal protease family protein AHiyo8_45290 ENOG4105C85 amino acid AHiyo8_45340 ENOG4105CHU acetyl-coa acetyltransferase AHiyo8_45350 ENOG4105CHU acetyl-coa acetyltransferase AHiyo8_45360 ENOG4105E39 Enoyl-CoA hydratase AHiyo8_45370 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AHiyo8_45390 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AHiyo8_45470 ENOG4105I1K ABC transporter AHiyo8_45500 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_45520 ENOG4105DXM phenylacetic acid degradation protein AHiyo8_45570 ENOG4105DZS Phenylacetate-CoA ligase AHiyo8_45580 ENOG4108ZJI phenylacetic acid degradation protein AHiyo8_45630 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AHiyo8_45720 ENOG4108KGH TRANSCRIPTIONal AHiyo8_45780 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AHiyo8_45850 ENOG4107QMS site-determining protein AHiyo8_45940 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AHiyo8_45950 ENOG4108KXV response regulator AHiyo8_46020 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit AHiyo8_46030 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit AHiyo8_46040 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit AHiyo8_46050 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit AHiyo8_46060 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit AHiyo8_46070 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AHiyo8_46190 ENOG41082SX arsR family transcriptional regulator AHiyo8_46270 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AHiyo8_46340 ENOG4105F9F transposase AHiyo8_46350 ENOG4105F9F transposase AHiyo8_46420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AHiyo8_46480 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AHiyo8_46490 ENOG4107ZF2 Phosphatase AHiyo8_46640 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AHiyo8_46650 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AHiyo8_46660 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AHiyo8_46690 ENOG4105F9F transposase AHiyo8_46700 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AHiyo8_46710 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AHiyo8_46730 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AHiyo8_46780 ENOG4107YJ4 chain length determinant protein AHiyo8_46800 ENOG4105EW9 transcriptional regulator AsnC family AHiyo8_46830 ENOG4105CPP Dehydrogenase, E1 component AHiyo8_46840 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 AHiyo8_46850 ENOG4105C7S Dehydrogenase AHiyo8_46860 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 AHiyo8_46970 ENOG4105WH1 Two component transcriptional regulator luxr family AHiyo8_47020 ENOG4105R8C Transcriptional regulator AHiyo8_47030 ENOG4105BZU Histidine kinase AHiyo8_47070 ENOG4105BZU Histidine kinase AHiyo8_47080 ENOG4105BZU Histidine kinase AHiyo8_47180 ENOG4105PGM cation diffusion facilitator family transporter AHiyo8_47200 ENOG4105F9F transposase AHiyo8_47210 ENOG4105F9F transposase AHiyo8_47230 ENOG4108NNZ chitinase AHiyo8_47280 ENOG4105CGD Nad-dependent epimerase dehydratase AHiyo8_47290 ENOG4105CGD Nad-dependent epimerase dehydratase AHiyo8_47300 ENOG4105MVE transcriptional regulator AHiyo8_47310 ENOG41082BM Transcriptional regulator, arsr family AHiyo8_47390 ENOG4108UHU Aldolase AHiyo8_47400 ENOG4105DJB Major Facilitator Superfamily AHiyo8_47410 ENOG4105CAT Cytidine monophosphate kinase AHiyo8_47590 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component AHiyo8_47600 ENOG4105DRS transport system, permease AHiyo8_47660 ENOG4107TCW O-succinylbenzoate synthase AHiyo8_47670 ENOG4107TCW O-succinylbenzoate synthase AHiyo8_47700 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AHiyo8_47710 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AHiyo8_47720 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AHiyo8_47730 ENOG4105CDA abc transporter atp-binding protein AHiyo8_47750 ENOG4108HW4 amino acid AbC transporter AHiyo8_47770 ENOG4105E4F Isochorismate synthase AHiyo8_47780 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AHiyo8_47790 ENOG4105P52 geranylgeranyl reductase AHiyo8_47850 ENOG4105EN6 Membrane AHiyo8_47870 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AHiyo8_47880 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AHiyo8_47950 ENOG4108IY8 ABC, transporter AHiyo8_47970 ENOG4108M8W Monooxygenase AHiyo8_47980 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AHiyo8_47990 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AHiyo8_48010 ENOG4107TPS domain protein AHiyo8_48020 ENOG4105JXH GntR family transcriptional regulator AHiyo8_48050 ENOG4108K8K Transcriptional regulator AHiyo8_48090 ENOG4105C26 Dehydrogenase AHiyo8_48100 ENOG4105C26 Dehydrogenase AHiyo8_48140 ENOG4105EQH reductase AHiyo8_48150 ENOG4105EQH reductase AHiyo8_48200 ENOG4107RR1 TRANSCRIPTIONal AHiyo8_48230 ENOG4105C26 Dehydrogenase AHiyo8_48240 ENOG4105C26 Dehydrogenase AHiyo8_48250 ENOG4105C26 Dehydrogenase AHiyo8_48280 ENOG4105CUB amino acid AHiyo8_48290 ENOG4105CUB amino acid AHiyo8_48310 ENOG4105CH6 catalase AHiyo8_48350 ENOG4105D0M Protease HtpX homolog AHiyo8_48370 ENOG4105DBE peroxidase AHiyo8_48380 ENOG410650H (LipO)protein AHiyo8_48400 ENOG4105EKT )-iron permease AHiyo8_48420 ENOG4108VPT UPF0234 protein AHiyo8_48440 ENOG4105VTR Integrase AHiyo8_48640 ENOG4105DDI hemolysin-type calcium-binding region AHiyo8_48710 ENOG41080RH Thioredoxin AHiyo8_48730 ENOG4105CEY Amp-dependent synthetase and ligase AHiyo8_48740 ENOG4105CEY Amp-dependent synthetase and ligase AHiyo8_48870 ENOG4107YPT transcriptional regulator AHiyo8_49200 ENOG4105FBN Acid phosphatase AHiyo8_49360 ENOG4108SHN Glycosyl transferase, family 2 AHiyo8_49440 ENOG4105FF5 Membrane AHiyo8_49480 ENOG4108STX response regulator AHiyo8_49500 ENOG4106F60 Histidine kinase AHiyo8_49520 ENOG4107UVD Beta-phosphoglucomutase family hydrolase AHiyo8_49560 ENOG410836F Transposase AHiyo8_49570 ENOG410836F Transposase AHiyo8_49640 ENOG4105BZ4 penicillin-binding protein AHiyo8_49700 ENOG4108ZT1 Transcriptional regulator AHiyo8_49810 ENOG41068JE domain protein AHiyo8_49850 ENOG4105DKQ ROK family AHiyo8_49870 ENOG4105CG3 alpha amylase, catalytic region AHiyo8_49910 ENOG4107QM2 Aldo Keto reductase AHiyo8_50020 ENOG410900P UPF0336 protein AHiyo8_50040 ENOG4106UW1 Major Facilitator superfamily AHiyo8_50050 ENOG4106UW1 Major Facilitator superfamily AHiyo8_50060 ENOG4107R4N Cell wall formation (By similarity) AHiyo8_50100 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AHiyo8_50130 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AHiyo8_50160 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AHiyo8_50170 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AHiyo8_50180 ENOG4107NHD transcriptional regulator AHiyo8_50220 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands AHiyo8_50230 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands AHiyo8_50250 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) AHiyo8_50400 ENOG4105WH1 Two component transcriptional regulator luxr family AHiyo8_50420 ENOG4105CHM Aminotransferase AHiyo8_50450 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AHiyo8_50460 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AHiyo8_50510 ENOG4108VZM 50s ribosomal protein L10 AHiyo8_50520 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AHiyo8_50530 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AHiyo8_50540 ENOG4105CHU acetyl-coa acetyltransferase AHiyo8_50550 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AHiyo8_50560 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AHiyo8_50570 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AHiyo8_50580 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AHiyo8_50590 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AHiyo8_50600 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AHiyo8_50610 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AHiyo8_50620 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AHiyo8_50720 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AHiyo8_50730 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AHiyo8_50740 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AHiyo8_50750 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AHiyo8_50770 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AHiyo8_50780 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AHiyo8_50790 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AHiyo8_50800 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AHiyo8_50810 ENOG41082SA 50s ribosomal protein l29 AHiyo8_50820 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AHiyo8_50830 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AHiyo8_50840 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AHiyo8_50850 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AHiyo8_50860 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AHiyo8_50870 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AHiyo8_50880 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AHiyo8_50890 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AHiyo8_50900 ENOG410849U 50S ribosomal protein L30 AHiyo8_50910 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AHiyo8_50920 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AHiyo8_50930 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AHiyo8_50940 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AHiyo8_50990 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component AHiyo8_51000 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AHiyo8_51040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AHiyo8_51150 ENOG4105KXX peptidase s58 dmpa AHiyo8_51160 ENOG4105KXX peptidase s58 dmpa AHiyo8_51170 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AHiyo8_51190 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AHiyo8_51200 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AHiyo8_51210 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AHiyo8_51220 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AHiyo8_51230 ENOG4108ZT0 50S ribosomal protein l17 AHiyo8_51240 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AHiyo8_51290 ENOG4107QMS site-determining protein AHiyo8_51380 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AHiyo8_51390 ENOG4108UJD 30S ribosomal protein S9 AHiyo8_51410 ENOG4105EDW glycosyl transferase, family 39 AHiyo8_51430 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AHiyo8_51440 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AHiyo8_51450 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AHiyo8_51460 ENOG4108VXD carboxy-peptidase AHiyo8_51480 ENOG4105CS9 pantothenic acid kinase AHiyo8_51490 ENOG4105CS9 pantothenic acid kinase AHiyo8_51500 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AHiyo8_51510 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AHiyo8_51520 ENOG4107QTJ carbohydrate kinase, YjeF related protein AHiyo8_51640 ENOG4105CPC Aldo Keto reductase AHiyo8_51680 ENOG4105CKU formyltetrahydrofolate synthetase AHiyo8_51690 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AHiyo8_51730 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AHiyo8_51740 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AHiyo8_51750 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AHiyo8_51790 ENOG4105M4B Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) AHiyo8_51810 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AHiyo8_51820 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) AHiyo8_51850 ENOG4108BRZ 50S ribosomal protein L36 AHiyo8_51860 ENOG4105F9E Shikimate 5-dehydrogenase AHiyo8_51900 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AHiyo8_51910 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AHiyo8_51920 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AHiyo8_51930 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AHiyo8_51940 ENOG4105EXC Acyl-transferase AHiyo8_51960 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AHiyo8_51970 ENOG4107QVP Dehydrogenase AHiyo8_51990 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AHiyo8_52040 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AHiyo8_52050 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AHiyo8_52130 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AHiyo8_52150 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AHiyo8_52260 ENOG4105C6Z Gluconate AHiyo8_52270 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AHiyo8_52320 ENOG4105CK5 oxidoreductase AHiyo8_52330 ENOG4105ETE Transcriptional regulator (LacI family AHiyo8_52340 ENOG4107KJX Transcriptional regulator AHiyo8_52350 ENOG4105D2H Uronic isomerase AHiyo8_52360 ENOG4105D2H Uronic isomerase AHiyo8_52370 ENOG4105DEI Mannitol dehydrogenase AHiyo8_52380 ENOG4105DEI Mannitol dehydrogenase AHiyo8_52390 ENOG4105CT4 transporter AHiyo8_52400 ENOG4105CT4 transporter AHiyo8_52420 ENOG4105CXK mandelate racemase muconate lactonizing AHiyo8_52430 ENOG4105CXK mandelate racemase muconate lactonizing AHiyo8_52440 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AHiyo8_52450 ENOG4105D17 glycoside hydrolase, family 3 domain protein AHiyo8_52460 ENOG4105D17 glycoside hydrolase, family 3 domain protein AHiyo8_52520 ENOG41083TI Protein CrcB homolog AHiyo8_52580 ENOG4105D7N magnesium and cobalt transport protein CorA AHiyo8_52660 ENOG4105C28 cystathionine AHiyo8_52670 ENOG4105D94 Major Facilitator Superfamily AHiyo8_52690 ENOG4105C5Q Transcriptional regulator AHiyo8_52730 ENOG4105EUB pirin domain protein AHiyo8_52770 ENOG4105E90 ABC transporter AHiyo8_52830 ENOG4105CSR polyphosphate kinase 2 AHiyo8_52840 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AHiyo8_52850 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AHiyo8_52860 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AHiyo8_52890 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AHiyo8_52910 ENOG4105C3G gtp-binding protein AHiyo8_52990 ENOG4108J59 Extracellular solute-binding protein, family 5 AHiyo8_53080 ENOG4108JQ7 (ABC) transporter AHiyo8_53100 ENOG4108J59 Extracellular solute-binding protein, family 5 AHiyo8_53110 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AHiyo8_53130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AHiyo8_53140 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AHiyo8_53190 ENOG4105CI3 gtp-binding protein typa AHiyo8_53240 ENOG4108Z4U Ferredoxin AHiyo8_53270 ENOG4105CMR udp-glucose 4-epimerase AHiyo8_53280 ENOG4105CMR udp-glucose 4-epimerase AHiyo8_53290 ENOG4105W1N transcriptional regulator AHiyo8_53350 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) AHiyo8_53360 ENOG4107R4C succinyl-diaminopimelate desuccinylase AHiyo8_53370 ENOG4107R4C succinyl-diaminopimelate desuccinylase AHiyo8_53380 ENOG4105DRP amino acid AbC transporter AHiyo8_53390 ENOG4108Q1T ABC transporter AHiyo8_53410 ENOG4106PMH Extracellular solute-binding protein family 3 AHiyo8_53420 ENOG4105CDA abc transporter atp-binding protein AHiyo8_53430 ENOG4108URH decarboxylase AHiyo8_53480 ENOG4107ZBN O-methyltransferase AHiyo8_53490 ENOG4105DU6 RNA polymerase AHiyo8_53500 ENOG4105DU6 RNA polymerase AHiyo8_53520 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) AHiyo8_53610 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AHiyo8_53640 ENOG4107T6F Xaa-Pro aminopeptidase AHiyo8_53650 ENOG4105DB7 PHP domain protein AHiyo8_53760 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AHiyo8_53770 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AHiyo8_53790 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AHiyo8_53880 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AHiyo8_53890 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AHiyo8_53900 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AHiyo8_53910 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AHiyo8_53920 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AHiyo8_53970 ENOG4107JTW chlorite dismutase AHiyo8_53980 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AHiyo8_53990 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AHiyo8_54010 ENOG4105D52 delta-aminolevulinic acid dehydratase AHiyo8_54030 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AHiyo8_54040 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AHiyo8_54060 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) AHiyo8_54070 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) AHiyo8_54080 ENOG4105CDA abc transporter atp-binding protein AHiyo8_54090 ENOG4105EAD ABC transporter AHiyo8_54100 ENOG4106TNF Periplasmic binding protein AHiyo8_54170 ENOG4105C4R Atp-dependent dna helicase AHiyo8_54230 ENOG4105E09 nadh pyrophosphatase AHiyo8_54270 ENOG41063PX domain protein AHiyo8_54280 ENOG4105DJZ UPF0182 protein AHiyo8_54300 ENOG4105DJZ UPF0182 protein AHiyo8_54310 ENOG4105DJZ UPF0182 protein AHiyo8_54360 ENOG4105C10 Electron transfer flavoprotein AHiyo8_54390 ENOG4105C1G acyl-Coa dehydrogenase AHiyo8_54400 ENOG41087YS Phage shock protein A AHiyo8_54430 ENOG4105C0H protease AHiyo8_54440 ENOG4105C0H protease AHiyo8_54450 ENOG4105BZJ Electron transfer flavoprotein AHiyo8_54460 ENOG4105C10 Electron transfer flavoprotein AHiyo8_54490 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AHiyo8_54500 ENOG4105C6Z Gluconate AHiyo8_54510 ENOG4105C6Z Gluconate AHiyo8_54520 ENOG4105C6Z Gluconate AHiyo8_54530 ENOG4108Z6Z Transcriptional regulator AHiyo8_54560 ENOG4105K6V RNA polymerase AHiyo8_54570 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AHiyo8_54590 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AHiyo8_54690 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AHiyo8_54700 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AHiyo8_54720 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AHiyo8_54730 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AHiyo8_54830 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AHiyo8_54850 ENOG4108WQ6 secreted protein AHiyo8_54910 ENOG4105BZU Histidine kinase AHiyo8_54930 ENOG4108T3R lipoprotein lpqB AHiyo8_54950 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AHiyo8_54970 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea AHiyo8_55000 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AHiyo8_55010 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AHiyo8_55130 ENOG4105C7I Dehydrogenase AHiyo8_55210 ENOG4105EC2 ftsk spoIIIe AHiyo8_55260 ENOG410602S Transferase AHiyo8_55290 ENOG4105EY8 ABC transporter AHiyo8_55320 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AHiyo8_55350 ENOG4105K64 Glycosyl transferase, family 2 AHiyo8_55430 ENOG4107QJZ Glycosyl transferase, family 2 AHiyo8_55440 ENOG4105C1B dTDP-glucose 4-6-dehydratase AHiyo8_55480 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) AHiyo8_55680 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AHiyo8_55690 ENOG4105CAK Cell division ATP-binding protein ftsE AHiyo8_55700 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) AHiyo8_55720 ENOG41061JJ Peptidase family M23 AHiyo8_55730 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AHiyo8_55770 ENOG4108PJD permease AHiyo8_55830 ENOG4105DQ6 Transposase AHiyo8_55890 ENOG4105C9B Cysteine desulfurase AHiyo8_55900 ENOG4105C9B Cysteine desulfurase AHiyo8_55910 ENOG4107TK4 histidinol-phosphate phosphatase AHiyo8_55930 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AHiyo8_55950 ENOG4105EMN RNA polymerase sigma factor AHiyo8_56000 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AHiyo8_56010 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AHiyo8_56100 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) AHiyo8_56120 ENOG4105CC5 ABC transporter AHiyo8_56160 ENOG4105KHC sulfurtransferase AHiyo8_56170 ENOG4105DQ4 alcohol dehydrogenase AHiyo8_56180 ENOG4105DQ4 alcohol dehydrogenase AHiyo8_56200 ENOG4105CQ7 ATP-dependent helicase AHiyo8_56220 ENOG4105CQ7 ATP-dependent helicase AHiyo8_56230 ENOG4105CQ7 ATP-dependent helicase AHiyo8_56240 ENOG4105CQ7 ATP-dependent helicase AHiyo8_56250 ENOG4105CQ7 ATP-dependent helicase AHiyo8_56310 ENOG4105D4Y metalloprotease AHiyo8_56380 ENOG4105C75 arginyL-tRNA synthetase AHiyo8_56390 ENOG4105C75 arginyL-tRNA synthetase AHiyo8_56400 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AHiyo8_56410 ENOG4105D6E homoserine dehydrogenase AHiyo8_56420 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) AHiyo8_56430 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AHiyo8_56460 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AHiyo8_56470 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AHiyo8_56530 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) AHiyo8_56540 ENOG4106DE0 ATP synthase AHiyo8_56550 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) AHiyo8_56560 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AHiyo8_56570 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AHiyo8_56580 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AHiyo8_56590 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AHiyo8_56600 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AHiyo8_56610 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AHiyo8_56640 ENOG4108SEA Esterase AHiyo8_56690 ENOG4105FF5 Membrane AHiyo8_56730 ENOG4105CI2 imidazolone-5-propionate hydrolase AHiyo8_56740 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) AHiyo8_56860 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AHiyo8_56890 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AHiyo8_56910 ENOG4105F8X type iii restriction AHiyo8_56920 ENOG4108RWI nicotinamidase AHiyo8_56960 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AHiyo8_57030 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AHiyo8_57040 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AHiyo8_57050 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AHiyo8_57060 ENOG4105DQR SNARE associated Golgi AHiyo8_57160 ENOG4105VG5 Membrane AHiyo8_57180 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AHiyo8_57190 ENOG4107RFY SbcCD D subunit AHiyo8_57210 ENOG4105EYH Exonuclease AHiyo8_57220 ENOG4105EYH Exonuclease AHiyo8_57240 ENOG4105EYH Exonuclease AHiyo8_57340 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 AHiyo8_57350 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 AHiyo8_57360 ENOG4105CPP Dehydrogenase, E1 component AHiyo8_57380 ENOG4105C85 amino acid AHiyo8_57390 ENOG4105C85 amino acid AHiyo8_57400 ENOG4105C85 amino acid AHiyo8_57430 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AHiyo8_57440 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AHiyo8_57460 ENOG4108IYU L-aspartate oxidase AHiyo8_57480 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AHiyo8_57490 ENOG4107QI6 Cysteine desulfurase AHiyo8_57510 ENOG4105C3J Cysteine desulfurase AHiyo8_57530 ENOG4105ERH Fumarylacetoacetate hydrolase AHiyo8_57620 ENOG4105DWT malate dehydrogenase (quinone) AHiyo8_57630 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AHiyo8_57690 ENOG4105C01 Dihydroxy-acid dehydratase AHiyo8_57700 ENOG4105C01 Dihydroxy-acid dehydratase AHiyo8_57710 ENOG4105C01 Dihydroxy-acid dehydratase AHiyo8_57720 ENOG4105C7K acetolactate synthase AHiyo8_57740 ENOG4108ZP8 Acetolactate synthase small subunit AHiyo8_57760 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AHiyo8_57780 ENOG4108JQ1 Dehydrogenase AHiyo8_57830 ENOG4105C19 ABC transporter AHiyo8_57840 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AHiyo8_57900 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AHiyo8_57910 ENOG4105CM2 brancheD-chain amino acid aminotransferase AHiyo8_57920 ENOG4105CM2 brancheD-chain amino acid aminotransferase AHiyo8_57950 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AHiyo8_57960 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase AHiyo8_57970 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AHiyo8_57980 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AHiyo8_58050 ENOG41069M3 Transcriptional regulator AHiyo8_58060 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AHiyo8_58070 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AHiyo8_58080 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AHiyo8_58090 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AHiyo8_58110 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AHiyo8_58140 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AHiyo8_58150 ENOG4105CPF Cell wall formation (By similarity) AHiyo8_58160 ENOG4105CPF Cell wall formation (By similarity) AHiyo8_58210 ENOG4105DP4 dak2 domain fusion protein ylov AHiyo8_58260 ENOG4106H78 methyltransferase AHiyo8_58280 ENOG4105CHM Aminotransferase AHiyo8_58300 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AHiyo8_58320 ENOG41062IY 50S ribosomal protein L32 AHiyo8_58330 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AHiyo8_58340 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AHiyo8_58350 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AHiyo8_58380 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AHiyo8_58390 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AHiyo8_58400 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AHiyo8_58500 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AHiyo8_58520 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AHiyo8_58560 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AHiyo8_58610 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AHiyo8_58630 ENOG4105K5M 30s ribosomal protein S16 AHiyo8_58640 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AHiyo8_58650 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AHiyo8_58660 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AHiyo8_58670 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AHiyo8_58680 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AHiyo8_58690 ENOG4107QYR Signal peptidase i AHiyo8_58710 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AHiyo8_58730 ENOG41080R2 UPF0102 protein AHiyo8_59150 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase AHiyo8_59180 ENOG4105CEC DNA methylase N-4 N-6 AHiyo8_59600 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AHiyo8_59630 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AHiyo8_59640 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AHiyo8_59650 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AHiyo8_59680 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AHiyo8_59690 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AHiyo8_59700 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AHiyo8_59770 ENOG4105CSH Transporter AHiyo8_59790 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase AHiyo8_59820 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AHiyo8_59830 ENOG4105CHR reductase AHiyo8_59840 ENOG4105CHR reductase AHiyo8_59850 ENOG4105CPQ Dehydrogenase AHiyo8_59880 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AHiyo8_59890 ENOG4105E1F short-chain dehydrogenase reductase AHiyo8_59920 ENOG4105C6T cysteine synthase AHiyo8_59940 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AHiyo8_59950 ENOG4105EGD dinuclear metal center protein, YbgI family AHiyo8_59960 ENOG4105EGD dinuclear metal center protein, YbgI family AHiyo8_60040 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AHiyo8_60050 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AHiyo8_60060 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AHiyo8_60080 ENOG4107JC6 Membrane AHiyo8_60120 ENOG41090CE integral membrane protein AHiyo8_60160 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AHiyo8_60230 ENOG4105C29 acyl-CoA thioesterase AHiyo8_60270 ENOG4105D8X mechanosensitive ion channel AHiyo8_60350 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AHiyo8_60360 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AHiyo8_60370 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AHiyo8_60380 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AHiyo8_60390 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AHiyo8_60400 ENOG4105MC2 DSBA oxidoreductase AHiyo8_60420 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AHiyo8_60430 ENOG4105K78 MarR family Transcriptional regulator AHiyo8_60470 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AHiyo8_60480 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AHiyo8_60490 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AHiyo8_60500 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AHiyo8_60510 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AHiyo8_60530 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AHiyo8_60570 ENOG4105C03 ribonuclease AHiyo8_60580 ENOG4105DWF phosphomethylpyrimidine kinase AHiyo8_60590 ENOG4105DWF phosphomethylpyrimidine kinase AHiyo8_60600 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AHiyo8_60610 ENOG4105K46 50S ribosomal protein l27 AHiyo8_60620 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AHiyo8_60630 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AHiyo8_60640 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AHiyo8_60670 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AHiyo8_60770 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AHiyo8_60780 ENOG4105C0B DNA polymerase III (alpha subunit) AHiyo8_60790 ENOG4105C0B DNA polymerase III (alpha subunit) AHiyo8_60800 ENOG4105C0B DNA polymerase III (alpha subunit) AHiyo8_60810 ENOG4105C0B DNA polymerase III (alpha subunit) AHiyo8_60820 ENOG4105C0B DNA polymerase III (alpha subunit) AHiyo8_60830 ENOG4105C0B DNA polymerase III (alpha subunit) AHiyo8_60880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AHiyo8_60960 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AHiyo8_60980 ENOG4108JQ5 ABC transporter AHiyo8_61030 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) AHiyo8_61040 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AHiyo8_61060 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AHiyo8_61070 ENOG4105DWY Agmatine deiminase AHiyo8_61100 ENOG4108RVA ribokinase AHiyo8_61140 ENOG4107UWP Major facilitator superfamily MFS_1 AHiyo8_61160 ENOG4105DTD Dehydrogenase AHiyo8_61180 ENOG4108RZE Tetr family transcriptional regulator AHiyo8_61210 ENOG41064MX Tetr family transcriptional regulator AHiyo8_61220 ENOG4105CMR udp-glucose 4-epimerase AHiyo8_61240 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AHiyo8_61270 ENOG4105E2R ROK family AHiyo8_61330 ENOG4105SYT Methylenetetrahydrofolate reductase AHiyo8_61350 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AHiyo8_61390 ENOG4107NQ8 LysR family Transcriptional regulator AHiyo8_61410 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AHiyo8_61420 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AHiyo8_61430 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AHiyo8_61570 ENOG4105BZU Histidine kinase AHiyo8_61580 ENOG4105BZU Histidine kinase AHiyo8_61600 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AHiyo8_61610 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AHiyo8_61620 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) AHiyo8_61640 ENOG4105DFS Conserved Protein AHiyo8_61850 ENOG4105C3M thioredoxin reductase AHiyo8_61870 ENOG4107VIJ nudix hydrolase AHiyo8_61880 ENOG4105MVE transcriptional regulator AHiyo8_61900 ENOG4105DQ4 alcohol dehydrogenase AHiyo8_61980 ENOG4105CQ7 ATP-dependent helicase AHiyo8_61990 ENOG4105CQ7 ATP-dependent helicase AHiyo8_62100 ENOG4107RTD sua5 ycio yrdc ywlc family protein AHiyo8_62190 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) AHiyo8_62210 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AHiyo8_62250 ENOG4105NAE bifunctional deaminase-reductase domain protein AHiyo8_62260 ENOG4105KA0 thioesterase Superfamily protein AHiyo8_62310 ENOG4105C2M dna polymerase I AHiyo8_62350 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AHiyo8_62360 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AHiyo8_62370 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AHiyo8_62380 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AHiyo8_62390 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AHiyo8_62400 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AHiyo8_62430 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AHiyo8_62440 ENOG4105DU1 integral membrane protein, terc AHiyo8_62570 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) AHiyo8_62630 ENOG4105BZ1 (ABC) transporter AHiyo8_62650 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AHiyo8_62660 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AHiyo8_62690 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AHiyo8_62700 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AHiyo8_62710 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AHiyo8_62720 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AHiyo8_62730 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AHiyo8_62740 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AHiyo8_62750 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AHiyo8_62760 ENOG4105CHW UPF0052 protein AHiyo8_62780 ENOG4105CIE May be required for sporulation (By similarity) AHiyo8_62800 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AHiyo8_62810 ENOG4105BZA Phosphoglycerate kinase AHiyo8_62820 ENOG4105CP7 Triose-phosphate isomerase AHiyo8_62850 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) AHiyo8_62900 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AHiyo8_62920 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AHiyo8_62930 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AHiyo8_62940 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) AHiyo8_62970 ENOG4105CJ1 ABC, transporter AHiyo8_63010 ENOG4105DIW FeS assembly protein SUFB AHiyo8_63040 ENOG4105C3K feS assembly ATPase SufC AHiyo8_63050 ENOG4105C3K feS assembly ATPase SufC AHiyo8_63060 ENOG4105VG1 fes assembly suf system protein AHiyo8_63130 ENOG4108JJB ABC transporter AHiyo8_63140 ENOG4107ZYJ bioY protein AHiyo8_63170 ENOG4105C5H ABC transporter AHiyo8_63250 ENOG4105CHR reductase AHiyo8_63260 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AHiyo8_63270 ENOG4105EAC phosphoserine phosphatase AHiyo8_63280 ENOG4105EAC phosphoserine phosphatase AHiyo8_63310 ENOG4105FCS tRNA rRNA methyltransferase AHiyo8_63350 ENOG4108KPJ rna polymerase sigma factor AHiyo8_63380 ENOG4105NRA 50s ribosomal protein l31 type b AHiyo8_63430 ENOG4107ZR7 Membrane AHiyo8_63570 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AHiyo8_63580 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AHiyo8_63590 ENOG4107QPH glycogen) synthase AHiyo8_63660 ENOG4105CHU acetyl-coa acetyltransferase AHiyo8_63670 ENOG4105CHU acetyl-coa acetyltransferase AHiyo8_63710 ENOG4105CHR reductase AHiyo8_63720 ENOG4105CHR reductase AHiyo8_63740 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AHiyo8_63810 ENOG4105CV8 reductase AHiyo8_63820 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AHiyo8_63840 ENOG4105C8N cysteinyl-tRNA synthetase AHiyo8_63860 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 AHiyo8_63890 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) AHiyo8_63900 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) AHiyo8_63910 ENOG4105E5F proteasome AHiyo8_63920 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) AHiyo8_63930 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) AHiyo8_63940 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) AHiyo8_63950 ENOG4108V1T peptidylprolyl cis-trans isomerase AHiyo8_64050 ENOG4105CQR helicase AHiyo8_64070 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AHiyo8_64080 ENOG4106178 UPF0339 protein AHiyo8_64100 ENOG4107TPY serine threonine protein kinase AHiyo8_64130 ENOG4108RTU Aldolase AHiyo8_64170 ENOG4105CSH Transporter AHiyo8_64180 ENOG4105CSH Transporter AHiyo8_64190 ENOG4105CPQ Dehydrogenase AHiyo8_64200 ENOG4105DEI Mannitol dehydrogenase AHiyo8_64210 ENOG4105DEI Mannitol dehydrogenase AHiyo8_64230 ENOG4105C5I Dehydrogenase AHiyo8_64280 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AHiyo8_64300 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AHiyo8_64350 ENOG4108IUS Transketolase AHiyo8_64360 ENOG4108HHA Transketolase AHiyo8_64480 ENOG4105CVK Glutamate decarboxylase AHiyo8_64530 ENOG4105C22 threonyL-tRNA synthetase AHiyo8_64540 ENOG4105C22 threonyL-tRNA synthetase AHiyo8_64570 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) AHiyo8_64590 ENOG4105DGW oligopeptidase A AHiyo8_64600 ENOG4105DGW oligopeptidase A AHiyo8_64650 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AHiyo8_64660 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) AHiyo8_64670 ENOG4105CDY transcriptional regulatory protein AHiyo8_64680 ENOG4105CDY transcriptional regulatory protein AHiyo8_64690 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) AHiyo8_64700 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AHiyo8_64710 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AHiyo8_64730 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AHiyo8_64740 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AHiyo8_64750 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AHiyo8_64760 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AHiyo8_64770 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AHiyo8_64800 ENOG4105C99 atpase involved in dna repair AHiyo8_64840 ENOG4105CUT histidyl-tRNA synthetase AHiyo8_64850 ENOG4105C9M aspartyl-trna synthetase AHiyo8_64860 ENOG4105C9M aspartyl-trna synthetase AHiyo8_64930 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AHiyo8_64960 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AHiyo8_64970 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AHiyo8_64980 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AHiyo8_64990 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AHiyo8_65000 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AHiyo8_65010 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AHiyo8_65050 ENOG4105E2X shikimate dehydrogenase AHiyo8_65060 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AHiyo8_65070 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AHiyo8_65080 ENOG4105D49 3-dehydroquinate synthase AHiyo8_65100 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AHiyo8_65110 ENOG410803B Involved in the transcription termination process (By similarity) AHiyo8_65120 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) AHiyo8_65140 ENOG4105CXT aspartate transcarbamylase AHiyo8_65150 ENOG4105CXT aspartate transcarbamylase AHiyo8_65160 ENOG4105CD3 dihydroorotase AHiyo8_65170 ENOG4105CD3 dihydroorotase AHiyo8_65180 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AHiyo8_65190 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AHiyo8_65200 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AHiyo8_65210 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AHiyo8_65220 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AHiyo8_65230 ENOG4105SKN orotidine 5''-phosphate decarboxylase AHiyo8_65240 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AHiyo8_65250 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AHiyo8_65260 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AHiyo8_65290 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AHiyo8_65300 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AHiyo8_65390 ENOG4105CV8 reductase AHiyo8_65400 ENOG4105DKT Transcriptional regulator AHiyo8_65420 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AHiyo8_65430 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AHiyo8_65440 ENOG4105C8T Leucyl-tRNA synthetase AHiyo8_65460 ENOG4105C8T Leucyl-tRNA synthetase AHiyo8_65470 ENOG4105C8T Leucyl-tRNA synthetase AHiyo8_65480 ENOG4105EPR degv family AHiyo8_65700 ENOG4105XTG Pfam:DUF156 AHiyo8_65750 ENOG41085GJ domain protein AHiyo8_65760 ENOG4105K63 Thioredoxin AHiyo8_pI65920 ENOG4108JQC penicillin-binding protein 1A AHiyo8_pI65930 ENOG4105BZ4 penicillin-binding protein AHiyo8_pI65990 ENOG4105C0R drug resistance transporter emrb qaca subfamily AHiyo8_pI66170 ENOG4105CVR type I restriction-modification system AHiyo8_pI66180 ENOG4105CVR type I restriction-modification system AHiyo8_pI66220 ENOG4105DZR Type I site-specific deoxyribonuclease AHiyo8_pI66230 ENOG4105DZR Type I site-specific deoxyribonuclease AHiyo8_pI66240 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 AHiyo8_pI66280 ENOG4105C2J ABC transporter AHiyo8_pI66300 ENOG4105CNN ABC, transporter AHiyo8_pI66360 ENOG4107WTH Galactitol-1-phosphate dehydrogenase AHiyo8_pI66380 ENOG4105C26 Dehydrogenase AHiyo8_pI66390 ENOG4105C26 Dehydrogenase AHiyo8_pI66400 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AHiyo8_pI66410 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AHiyo8_pI66450 ENOG4108C33 Resolvase AHiyo8_pI66460 ENOG4105PAD Hydrolase AHiyo8_pI66500 ENOG4107QJE Chromosome Partitioning Protein AHiyo8_pI66990 ENOG4105C19 ABC transporter AHiyo8_pI67000 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AHiyo8_pI67010 ENOG4108C33 Resolvase AHiyo8_pI67050 ENOG4105D13 transposase AHiyo8_pI67290 ENOG4105BZU Histidine kinase AHiyo8_pI67310 ENOG4105F9F transposase AHiyo8_pI67320 ENOG4108MRH transcriptional regulatory protein AHiyo8_pI67330 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AHiyo8_pI67360 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AHiyo8_pI67370 ENOG4105E2Y ABC, transporter AHiyo8_pI67380 ENOG4105D7T ABC transporter AHiyo8_pI67430 ENOG4107QNK )-transporter AHiyo8_pI67470 ENOG4108ZT1 Transcriptional regulator AHiyo8_pI67510 ENOG4105BZ4 penicillin-binding protein AHiyo8_pI67620 ENOG4108C33 Resolvase AHiyo8_pI67760 ENOG4105CJP fad dependent oxidoreductase AHiyo8_pI67880 ENOG4105CDA abc transporter atp-binding protein AHiyo8_pI67890 ENOG4105E5Q amino acid AbC transporter AHiyo8_pI67930 ENOG4105CJP fad dependent oxidoreductase AHiyo8_pI67940 ENOG4105CJP fad dependent oxidoreductase AHiyo8_pI67960 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AHiyo8_pI67970 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AHiyo8_pI67980 ENOG4108IJ0 Aspartate ammonia-lyase AHiyo8_pI67990 ENOG4108IJ0 Aspartate ammonia-lyase AHiyo8_pI68050 ENOG4108JPW Aminotransferase AHiyo8_pI68120 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AHiyo8_pI68170 ENOG41073TP transcriptional regulator AHiyo8_pI68190 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase AHiyo8_pI68260 ENOG4105C8Y Acetylornithine aminotransferase AHiyo8_pI68420 ENOG4105VPX protein, conserved in bacteria AHiyo8_pI68430 ENOG4108M4U conserved membrane protein AHiyo8_pI68440 ENOG4108M4U conserved membrane protein AHiyo8_pI68500 ENOG4105DRR Transcriptional regulator, GntR family AHiyo8_pI68580 ENOG4108KQ5 Integrase catalytic subunit AHiyo8_pI68610 ENOG4105BZW Glycerate kinase AHiyo8_pI68620 ENOG4105BZW Glycerate kinase AHiyo8_pI68660 ENOG4105E8G Major facilitator Superfamily AHiyo8_pI68690 ENOG4108JQ7 (ABC) transporter AHiyo8_pI68710 ENOG4105C3U ABC transporter AHiyo8_pI68740 ENOG4108RJS alcohol dehydrogenase AHiyo8_pI68880 ENOG4107Y80 Major Facilitator superfamily AHiyo8_pI69030 ENOG410836F Transposase AHiyo8_pI69320 ENOG4107QUV Domain protein AHiyo8_pI69370 ENOG4108IUX (ABC) transporter AHiyo8_pI69430 ENOG4105EKQ RNA-directed DNA polymerase AHiyo8_pI69710 ENOG4108C33 Resolvase AHiyo8_pI69870 ENOG410836F Transposase AHiyo8_pI69930 ENOG4105F9F transposase AHiyo8_pI70050 ENOG4105XTG Pfam:DUF156 AHiyo8_pI70090 ENOG41085GJ domain protein AHiyo8_pI70100 ENOG4105K63 Thioredoxin AHiyo8_pI70110 ENOG4105C5X domain protein AHiyo8_pII70170 ENOG4108C33 Resolvase AHiyo8_pII70280 ENOG4108C33 Resolvase AHiyo8_pII70370 ENOG4108C33 Resolvase