locus-tag	class	description
AHiyo8_00010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AHiyo8_00060	COG0477	Major facilitator Superfamily
AHiyo8_00070	COG1846	Transcriptional regulator
AHiyo8_00540	COG1074	ATP-dependent DNA helicase activity
AHiyo8_00620	COG1432	Conserved Protein
AHiyo8_00650	COG1793	dna ligase
AHiyo8_00770	COG1401	restriction endodeoxyribonuclease activity
AHiyo8_00880	COG0210	DNA helicase
AHiyo8_00900	COG0210	DNA helicase
AHiyo8_00910	COG0210	DNA helicase
AHiyo8_01230	COG2184	nucleotidyltransferase activity
AHiyo8_01460	COG1266	CAAX protease self-immunity
AHiyo8_01620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AHiyo8_01670	COG0657	acetylesterase activity
AHiyo8_01800	COG0542	response to heat
AHiyo8_01820	COG0210	DNA helicase
AHiyo8_01970	COG0085	RNA polymerase activity
AHiyo8_02340	COG1002	Type II restriction enzyme, methylase subunits
AHiyo8_02350	COG1061	Type III restriction enzyme res subunit
AHiyo8_02450	COG0477	Major facilitator Superfamily
AHiyo8_02460	COG0477	Major facilitator Superfamily
AHiyo8_02520	COG2072	flavoprotein involved in K transport
AHiyo8_02550	COG1414	Transcriptional regulator
AHiyo8_02590	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_02620	COG0145	ligase activity
AHiyo8_02650	COG0145	ligase activity
AHiyo8_02690	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AHiyo8_02760	COG0583	DNA-binding transcription factor activity
AHiyo8_02880	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AHiyo8_02990	COG3485	protocatechuate 3,4-dioxygenase
AHiyo8_03020	COG1414	Transcriptional regulator
AHiyo8_03110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AHiyo8_03170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AHiyo8_03210	COG1414	Transcriptional regulator
AHiyo8_03220	COG1129	ABC transporter
AHiyo8_03240	COG1129	ABC transporter
AHiyo8_03330	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_03340	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_03350	COG1063	alcohol dehydrogenase
AHiyo8_03360	COG3265	gluconokinase activity
AHiyo8_03370	COG2390	Transcriptional regulator
AHiyo8_03400	COG2814	Major facilitator Superfamily
AHiyo8_03440	COG0346	lactoylglutathione lyase activity
AHiyo8_03490	COG3290	protein histidine kinase activity
AHiyo8_03500	COG3290	protein histidine kinase activity
AHiyo8_03510	COG3290	protein histidine kinase activity
AHiyo8_03520	COG1116	anion transmembrane transporter activity
AHiyo8_03600	COG2826	transposase and inactivated derivatives, IS30 family
AHiyo8_03840	COG4152	abc transporter atp-binding protein
AHiyo8_03920	COG1175	transmembrane transport
AHiyo8_03960	COG0366	Alpha amylase catalytic
AHiyo8_04100	COG0768	penicillin binding
AHiyo8_04110	COG0768	penicillin binding
AHiyo8_04130	COG1595	DNA-templated transcription, initiation
AHiyo8_04220	COG0268	Binds directly to 16S ribosomal RNA
AHiyo8_04240	COG0481	GTPase activity
AHiyo8_04290	COG1420	regulation of RNA biosynthetic process
AHiyo8_04300	COG1420	regulation of RNA biosynthetic process
AHiyo8_04310	COG0484	heat shock protein binding
AHiyo8_04320	COG0484	heat shock protein binding
AHiyo8_04330	COG0484	heat shock protein binding
AHiyo8_04340	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AHiyo8_04390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AHiyo8_04430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AHiyo8_04460	COG1316	TRANSCRIPTIONal
AHiyo8_04480	COG3590	peptidase
AHiyo8_04490	COG3590	peptidase
AHiyo8_04520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AHiyo8_04530	COG1381	Involved in DNA repair and RecF pathway recombination
AHiyo8_04540	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AHiyo8_04550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AHiyo8_04560	COG2267	carboxylic ester hydrolase activity
AHiyo8_04600	COG3573	Dehydrogenase
AHiyo8_04610	COG0167	dihydroorotate dehydrogenase activity
AHiyo8_04620	COG0167	dihydroorotate dehydrogenase activity
AHiyo8_04640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AHiyo8_04660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AHiyo8_04670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AHiyo8_04680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AHiyo8_04690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AHiyo8_04710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AHiyo8_04720	COG2188	Transcriptional regulator
AHiyo8_04740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AHiyo8_04750	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AHiyo8_04760	COG0723	plastoquinol--plastocyanin reductase activity
AHiyo8_04770	COG2010	Cytochrome c
AHiyo8_04780	COG1845	cytochrome c oxidase, subunit III
AHiyo8_04790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AHiyo8_04800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AHiyo8_04860	COG1316	TRANSCRIPTIONal
AHiyo8_04870	COG1280	lysine exporter protein (LysE YggA)
AHiyo8_04920	COG1335	isochorismatase
AHiyo8_04950	COG0384	phenazine biosynthesis protein PhzF
AHiyo8_05020	COG0242	peptide deformylase activity
AHiyo8_05030	COG1506	peptidase
AHiyo8_05030	COG0823	Involved in the tonB-independent uptake of proteins
AHiyo8_05030	COG4946	Tricorn protease homolog
AHiyo8_05150	COG0477	Major facilitator Superfamily
AHiyo8_05160	COG1396	sequence-specific DNA binding
AHiyo8_05190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AHiyo8_05200	COG1024	Enoyl-CoA hydratase
AHiyo8_05210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AHiyo8_05230	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_05250	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo8_05380	COG2814	Major facilitator Superfamily
AHiyo8_05420	COG3347	Dehydrogenase
AHiyo8_05420	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_05430	COG3347	Dehydrogenase
AHiyo8_05430	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_05440	COG4952	isomerase
AHiyo8_05470	COG3226	Transcriptional regulator
AHiyo8_05520	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo8_05530	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo8_05540	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo8_05590	COG1609	Transcriptional regulator
AHiyo8_05610	COG1609	Transcriptional regulator
AHiyo8_05670	COG0395	ABC-type sugar transport system, permease component
AHiyo8_05680	COG0395	ABC-type sugar transport system, permease component
AHiyo8_05690	COG3534	alpha-L-arabinofuranosidase
AHiyo8_05720	COG2160	L-arabinose isomerase activity
AHiyo8_05730	COG2160	L-arabinose isomerase activity
AHiyo8_05800	COG1609	Transcriptional regulator
AHiyo8_05820	COG1063	alcohol dehydrogenase
AHiyo8_05850	COG3387	PFAM Glycoside hydrolase 15-related
AHiyo8_05900	COG1129	ABC transporter
AHiyo8_05920	COG4214	carbohydrate transport
AHiyo8_06020	COG0318	PFAM AMP-dependent synthetase and ligase
AHiyo8_06030	COG0318	PFAM AMP-dependent synthetase and ligase
AHiyo8_06040	COG1215	transferase activity, transferring glycosyl groups
AHiyo8_06120	COG2902	Dehydrogenase
AHiyo8_06130	COG2902	Dehydrogenase
AHiyo8_06140	COG2902	Dehydrogenase
AHiyo8_06150	COG2902	Dehydrogenase
AHiyo8_06180	COG0598	Magnesium transport protein CorA
AHiyo8_06190	COG5434	Belongs to the glycosyl hydrolase 28 family
AHiyo8_06190	COG4632	Exopolysaccharide biosynthesis protein
AHiyo8_06200	COG0406	alpha-ribazole phosphatase activity
AHiyo8_06250	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AHiyo8_06270	COG1309	transcriptional regulator
AHiyo8_06280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AHiyo8_06310	COG2124	cytochrome p450
AHiyo8_06410	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AHiyo8_06460	COG4941	Belongs to the sigma-70 factor family
AHiyo8_06470	COG4941	Belongs to the sigma-70 factor family
AHiyo8_06490	COG3795	YCII-related domain
AHiyo8_06580	COG1131	(ABC) transporter
AHiyo8_06590	COG1131	(ABC) transporter
AHiyo8_06700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AHiyo8_06720	COG0667	Aldo Keto reductase
AHiyo8_06730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AHiyo8_06760	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AHiyo8_06780	COG0789	Transcriptional regulator
AHiyo8_06790	COG3118	belongs to the thioredoxin family
AHiyo8_06890	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AHiyo8_06900	COG0633	Ferredoxin
AHiyo8_06900	COG0543	2 iron, 2 sulfur cluster binding
AHiyo8_06920	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AHiyo8_06930	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AHiyo8_07170	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_07280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AHiyo8_07340	COG0492	ferredoxin-NADP+ reductase activity
AHiyo8_07340	COG3118	belongs to the thioredoxin family
AHiyo8_07390	COG2909	trisaccharide binding
AHiyo8_07470	COG1175	transmembrane transport
AHiyo8_07490	COG1653	transport
AHiyo8_07500	COG1609	Transcriptional regulator
AHiyo8_07510	COG1609	Transcriptional regulator
AHiyo8_07540	COG0436	Aminotransferase
AHiyo8_07640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AHiyo8_07680	COG0302	gtp cyclohydrolase
AHiyo8_07690	COG0302	gtp cyclohydrolase
AHiyo8_07700	COG1063	alcohol dehydrogenase
AHiyo8_07710	COG1063	alcohol dehydrogenase
AHiyo8_07760	COG0517	IMP dehydrogenase activity
AHiyo8_07760	COG4175	Glycine betaine
AHiyo8_07770	COG0517	IMP dehydrogenase activity
AHiyo8_07770	COG4175	Glycine betaine
AHiyo8_07790	COG4176	ABC-type proline glycine betaine transport system permease component
AHiyo8_07830	COG0477	Major facilitator Superfamily
AHiyo8_07840	COG0477	Major facilitator Superfamily
AHiyo8_07860	COG0583	DNA-binding transcription factor activity
AHiyo8_07930	COG0667	Aldo Keto reductase
AHiyo8_07950	COG5492	domain, Protein
AHiyo8_07980	COG0395	ABC-type sugar transport system, permease component
AHiyo8_08000	COG1653	transport
AHiyo8_08010	COG1349	DNA-binding transcription factor activity
AHiyo8_08130	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AHiyo8_08150	COG4585	Histidine kinase
AHiyo8_08230	COG2217	Heavy metal translocating P-type atpase
AHiyo8_08280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AHiyo8_08300	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AHiyo8_08330	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AHiyo8_08350	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AHiyo8_08360	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AHiyo8_08480	COG1131	(ABC) transporter
AHiyo8_08530	COG3152	Membrane
AHiyo8_08560	COG2249	NAD(P)H dehydrogenase (quinone) activity
AHiyo8_08590	COG1301	dicarboxylic acid transport
AHiyo8_08600	COG1301	dicarboxylic acid transport
AHiyo8_08620	COG2828	Protein conserved in bacteria
AHiyo8_08700	COG0071	Belongs to the small heat shock protein (HSP20) family
AHiyo8_08710	COG0484	heat shock protein binding
AHiyo8_08820	COG0747	negative chemotaxis
AHiyo8_08860	COG0444	Belongs to the ABC transporter superfamily
AHiyo8_08870	COG4608	Belongs to the ABC transporter superfamily
AHiyo8_08880	COG4608	Belongs to the ABC transporter superfamily
AHiyo8_08910	COG1621	beta-fructofuranosidase activity
AHiyo8_08920	COG1621	beta-fructofuranosidase activity
AHiyo8_09020	COG1472	Belongs to the glycosyl hydrolase 3 family
AHiyo8_09050	COG5416	Lipopolysaccharide assembly protein A domain
AHiyo8_09130	COG1309	transcriptional regulator
AHiyo8_09210	COG0395	ABC-type sugar transport system, permease component
AHiyo8_09240	COG1609	Transcriptional regulator
AHiyo8_09280	COG1621	beta-fructofuranosidase activity
AHiyo8_09290	COG1621	beta-fructofuranosidase activity
AHiyo8_09360	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_09390	COG0395	ABC-type sugar transport system, permease component
AHiyo8_09440	COG1653	transport
AHiyo8_09500	COG1609	Transcriptional regulator
AHiyo8_09530	COG0800	Aldolase
AHiyo8_09550	COG0477	Major facilitator Superfamily
AHiyo8_09560	COG0477	Major facilitator Superfamily
AHiyo8_09600	COG0667	Aldo Keto reductase
AHiyo8_09640	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_09710	COG3250	beta-galactosidase activity
AHiyo8_09720	COG2211	Major facilitator Superfamily
AHiyo8_09780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AHiyo8_09870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AHiyo8_09880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AHiyo8_09910	COG2723	6-phospho-beta-galactosidase activity
AHiyo8_09930	COG2723	6-phospho-beta-galactosidase activity
AHiyo8_09940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AHiyo8_09940	COG2190	(PTS) system
AHiyo8_09940	COG1263	PTS System
AHiyo8_09970	COG2190	(PTS) system
AHiyo8_09970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AHiyo8_09970	COG1263	PTS System
AHiyo8_10000	COG0656	L-ascorbic acid biosynthetic process
AHiyo8_10020	COG0667	Aldo Keto reductase
AHiyo8_10110	COG0067	glutamate synthase
AHiyo8_10110	COG0069	glutamate synthase activity
AHiyo8_10110	COG0070	glutamate synthase
AHiyo8_10130	COG0069	glutamate synthase activity
AHiyo8_10130	COG0070	glutamate synthase
AHiyo8_10130	COG0067	glutamate synthase
AHiyo8_10140	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AHiyo8_10170	COG0159	tryptophan synthase activity
AHiyo8_10180	COG0133	tryptophan synthase activity
AHiyo8_10190	COG0133	tryptophan synthase activity
AHiyo8_10200	COG0134	indole-3-glycerol-phosphate synthase activity
AHiyo8_10240	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AHiyo8_10260	COG0107	imidazoleglycerol-phosphate synthase activity
AHiyo8_10270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AHiyo8_10280	COG0140	phosphoribosyl-ATP diphosphatase activity
AHiyo8_10290	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AHiyo8_10300	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AHiyo8_10300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AHiyo8_10370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AHiyo8_10400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AHiyo8_10410	COG0242	peptide deformylase activity
AHiyo8_10440	COG3706	GGDEF domain
AHiyo8_10460	COG0531	amino acid
AHiyo8_10470	COG3135	benzoate transporter
AHiyo8_10560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AHiyo8_10640	COG0183	Belongs to the thiolase family
AHiyo8_10660	COG1024	Enoyl-CoA hydratase
AHiyo8_10660	COG1250	3-hydroxyacyl-CoA dehydrogenase
AHiyo8_10680	COG0667	Aldo Keto reductase
AHiyo8_10710	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AHiyo8_10720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AHiyo8_10730	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AHiyo8_10740	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AHiyo8_10750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AHiyo8_10760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AHiyo8_10770	COG0531	amino acid
AHiyo8_10780	COG0569	domain protein
AHiyo8_10840	COG0756	dUTP diphosphatase activity
AHiyo8_10890	COG1435	thymidine kinase activity
AHiyo8_10950	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AHiyo8_11000	COG4988	ABC transporter
AHiyo8_11030	COG4988	ABC transporter
AHiyo8_11040	COG1294	oxidase, subunit
AHiyo8_11050	COG1271	oxidase subunit
AHiyo8_11060	COG1271	oxidase subunit
AHiyo8_11090	COG0187	DNA topoisomerase II activity
AHiyo8_11170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AHiyo8_11180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AHiyo8_11260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AHiyo8_11270	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AHiyo8_11290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AHiyo8_11300	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHiyo8_11330	COG1764	response to oxidative stress
AHiyo8_11340	COG0793	Belongs to the peptidase S41A family
AHiyo8_11340	COG4946	Tricorn protease homolog
AHiyo8_11350	COG4946	Tricorn protease homolog
AHiyo8_11350	COG0793	Belongs to the peptidase S41A family
AHiyo8_11370	COG4946	Tricorn protease homolog
AHiyo8_11370	COG0793	Belongs to the peptidase S41A family
AHiyo8_11380	COG0793	Belongs to the peptidase S41A family
AHiyo8_11380	COG4946	Tricorn protease homolog
AHiyo8_11400	COG1090	epimerase
AHiyo8_11430	COG0321	lipoyl(octanoyl) transferase activity
AHiyo8_11440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AHiyo8_11470	COG0174	glutamine synthetase
AHiyo8_11510	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AHiyo8_11520	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AHiyo8_11540	COG0174	glutamine synthetase
AHiyo8_11550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AHiyo8_11580	COG1940	carbohydrate kinase activity
AHiyo8_11590	COG1940	carbohydrate kinase activity
AHiyo8_11600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AHiyo8_11610	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AHiyo8_11620	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AHiyo8_11630	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AHiyo8_11660	COG0587	DNA-directed DNA polymerase activity
AHiyo8_11670	COG0587	DNA-directed DNA polymerase activity
AHiyo8_11680	COG0587	DNA-directed DNA polymerase activity
AHiyo8_11710	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AHiyo8_11760	COG1799	cell septum assembly
AHiyo8_11770	COG1799	cell septum assembly
AHiyo8_11780	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AHiyo8_11800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AHiyo8_11810	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AHiyo8_11840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AHiyo8_11850	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AHiyo8_11860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AHiyo8_11870	COG0772	Belongs to the SEDS family
AHiyo8_11890	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AHiyo8_11900	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AHiyo8_11910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AHiyo8_11920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AHiyo8_11940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AHiyo8_11970	COG0768	penicillin binding
AHiyo8_12000	COG0275	rRNA processing
AHiyo8_12010	COG2001	Belongs to the MraZ family
AHiyo8_12060	COG0142	geranyltranstransferase activity
AHiyo8_12090	COG3942	CHAP domain
AHiyo8_12090	COG1388	LysM domain
AHiyo8_12100	COG0741	lytic transglycosylase activity
AHiyo8_12110	COG0515	serine threonine protein kinase
AHiyo8_12110	COG2815	serine threonine protein kinase
AHiyo8_12120	COG2815	serine threonine protein kinase
AHiyo8_12120	COG0515	serine threonine protein kinase
AHiyo8_12130	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AHiyo8_12200	COG1940	carbohydrate kinase activity
AHiyo8_12230	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AHiyo8_12240	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AHiyo8_12310	COG1716	ATPase activity
AHiyo8_12320	COG0509	glycine decarboxylation via glycine cleavage system
AHiyo8_12330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AHiyo8_12340	COG2814	Major facilitator Superfamily
AHiyo8_12360	COG1846	Transcriptional regulator
AHiyo8_12370	COG2824	Alkylphosphonate utilization operon protein PhnA
AHiyo8_12380	COG1160	GTP binding
AHiyo8_12390	COG1160	GTP binding
AHiyo8_12420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AHiyo8_12430	COG0287	Prephenate dehydrogenase
AHiyo8_12470	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AHiyo8_12490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AHiyo8_12510	COG1301	dicarboxylic acid transport
AHiyo8_12530	COG3290	protein histidine kinase activity
AHiyo8_12540	COG4565	transcriptional regulatory protein
AHiyo8_12550	COG2079	MmgE PrpD family protein
AHiyo8_12570	COG2079	MmgE PrpD family protein
AHiyo8_12580	COG2079	MmgE PrpD family protein
AHiyo8_12680	COG0504	CTP synthase activity
AHiyo8_12690	COG0497	DNA recombination
AHiyo8_12720	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AHiyo8_12800	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AHiyo8_12810	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AHiyo8_12870	COG2094	Belongs to the DNA glycosylase MPG family
AHiyo8_12900	COG0165	Argininosuccinate lyase
AHiyo8_12920	COG0137	argininosuccinate synthase activity
AHiyo8_12930	COG1438	arginine binding
AHiyo8_12940	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AHiyo8_12950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AHiyo8_12960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AHiyo8_12980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AHiyo8_12990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AHiyo8_13000	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AHiyo8_13020	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AHiyo8_13140	COG0072	phenylalanine-tRNA ligase activity
AHiyo8_13140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AHiyo8_13150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AHiyo8_13150	COG0072	phenylalanine-tRNA ligase activity
AHiyo8_13160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AHiyo8_13170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AHiyo8_13190	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AHiyo8_13230	COG2814	Major facilitator Superfamily
AHiyo8_13240	COG2814	Major facilitator Superfamily
AHiyo8_13260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AHiyo8_13270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AHiyo8_13280	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AHiyo8_13290	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AHiyo8_13350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AHiyo8_13370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AHiyo8_13380	COG0131	Imidazoleglycerol-phosphate dehydratase
AHiyo8_13390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AHiyo8_13410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AHiyo8_13420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AHiyo8_13450	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AHiyo8_13470	COG2813	Specifically methylates the guanine in position
AHiyo8_13480	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AHiyo8_13490	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AHiyo8_13500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AHiyo8_13510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AHiyo8_13530	COG2137	regulation of response to DNA damage stimulus
AHiyo8_13540	COG2137	regulation of response to DNA damage stimulus
AHiyo8_13550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AHiyo8_13560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AHiyo8_13590	COG1396	sequence-specific DNA binding
AHiyo8_13600	COG1546	Belongs to the CinA family
AHiyo8_13600	COG1058	Belongs to the CinA family
AHiyo8_13620	COG1674	ftsk spoiiie
AHiyo8_13650	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AHiyo8_13670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AHiyo8_13710	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AHiyo8_13720	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AHiyo8_13730	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AHiyo8_13740	COG0521	Mo-molybdopterin cofactor biosynthetic process
AHiyo8_13750	COG0315	cyclic pyranopterin monophosphate synthase activity
AHiyo8_13810	COG2202	Pas domain
AHiyo8_13810	COG2205	protein histidine kinase activity
AHiyo8_13820	COG0745	RESPONSE REGULATOR receiver
AHiyo8_13880	COG0612	Peptidase, M16
AHiyo8_13890	COG1185	polyribonucleotide nucleotidyltransferase activity
AHiyo8_13900	COG1185	polyribonucleotide nucleotidyltransferase activity
AHiyo8_13910	COG1185	polyribonucleotide nucleotidyltransferase activity
AHiyo8_13920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AHiyo8_13930	COG3483	tryptophan 2,3-dioxygenase activity
AHiyo8_13970	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AHiyo8_13980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AHiyo8_14010	COG0436	Aminotransferase
AHiyo8_14020	COG0590	tRNA wobble adenosine to inosine editing
AHiyo8_14030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AHiyo8_14040	COG0481	GTPase activity
AHiyo8_14040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AHiyo8_14050	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AHiyo8_14050	COG0481	GTPase activity
AHiyo8_14070	COG0481	GTPase activity
AHiyo8_14070	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AHiyo8_14100	COG0195	Participates in both transcription termination and antitermination
AHiyo8_14110	COG0779	Required for maturation of 30S ribosomal subunits
AHiyo8_14170	COG0442	prolyl-tRNA aminoacylation
AHiyo8_14180	COG1131	(ABC) transporter
AHiyo8_14230	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AHiyo8_14240	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AHiyo8_14250	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AHiyo8_14270	COG0750	zinc metalloprotease
AHiyo8_14280	COG0750	zinc metalloprotease
AHiyo8_14290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AHiyo8_14300	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AHiyo8_14400	COG1960	acyl-CoA dehydrogenase activity
AHiyo8_14450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AHiyo8_14480	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHiyo8_14490	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHiyo8_14500	COG0022	dehydrogenase e1 component
AHiyo8_14520	COG1522	sequence-specific DNA binding
AHiyo8_14560	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AHiyo8_14570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AHiyo8_14580	COG3275	phosphorelay sensor kinase activity
AHiyo8_14610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AHiyo8_14650	COG0233	cytoplasmic translational termination
AHiyo8_14660	COG0528	UMP kinase activity
AHiyo8_14670	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AHiyo8_14680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AHiyo8_14690	COG0052	Belongs to the universal ribosomal protein uS2 family
AHiyo8_14710	COG1960	acyl-CoA dehydrogenase activity
AHiyo8_14780	COG2826	transposase and inactivated derivatives, IS30 family
AHiyo8_14800	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_14860	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AHiyo8_14940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AHiyo8_14980	COG0358	DNA primase activity
AHiyo8_14990	COG0358	DNA primase activity
AHiyo8_15030	COG2197	response regulator
AHiyo8_15040	COG0842	Transport permease protein
AHiyo8_15050	COG1131	(ABC) transporter
AHiyo8_15110	COG0423	glycine-tRNA ligase activity
AHiyo8_15190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AHiyo8_15270	COG2873	o-acetylhomoserine
AHiyo8_15340	COG0191	fructose-bisphosphate aldolase activity
AHiyo8_15370	COG1940	carbohydrate kinase activity
AHiyo8_15400	COG1228	amidohydrolase
AHiyo8_15410	COG1228	amidohydrolase
AHiyo8_15450	COG1486	melibiose metabolic process
AHiyo8_15460	COG1486	melibiose metabolic process
AHiyo8_15480	COG0156	8-amino-7-oxononanoate synthase activity
AHiyo8_15490	COG0156	8-amino-7-oxononanoate synthase activity
AHiyo8_15500	COG1063	alcohol dehydrogenase
AHiyo8_15510	COG1063	alcohol dehydrogenase
AHiyo8_15590	COG0395	ABC-type sugar transport system, permease component
AHiyo8_15600	COG1175	transmembrane transport
AHiyo8_15670	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AHiyo8_15680	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AHiyo8_15690	COG0154	amidase activity
AHiyo8_15710	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AHiyo8_15720	COG2851	Citrate transporter
AHiyo8_15760	COG5000	phosphorelay sensor kinase activity
AHiyo8_15780	COG4565	transcriptional regulatory protein
AHiyo8_15800	COG0456	acetyltransferase
AHiyo8_15820	COG0483	inositol monophosphate 1-phosphatase activity
AHiyo8_15830	COG0483	inositol monophosphate 1-phosphatase activity
AHiyo8_15840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AHiyo8_15850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AHiyo8_15880	COG0631	protein serine/threonine phosphatase activity
AHiyo8_15910	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AHiyo8_15910	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AHiyo8_15950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AHiyo8_15980	COG0393	Putative heavy-metal-binding
AHiyo8_16010	COG2409	Drug exporters of the RND superfamily
AHiyo8_16020	COG2409	Drug exporters of the RND superfamily
AHiyo8_16030	COG0424	maF-like protein
AHiyo8_16040	COG4770	biotin carboxylase activity
AHiyo8_16050	COG4770	biotin carboxylase activity
AHiyo8_16060	COG0477	Major facilitator Superfamily
AHiyo8_16120	COG0243	molybdopterin cofactor binding
AHiyo8_16270	COG1621	beta-fructofuranosidase activity
AHiyo8_16300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AHiyo8_16310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AHiyo8_16370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AHiyo8_16370	COG2146	nitrite reductase [NAD(P)H] activity
AHiyo8_16380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AHiyo8_16380	COG1648	precorrin-2 dehydrogenase activity
AHiyo8_16410	COG2814	Major facilitator Superfamily
AHiyo8_16420	COG2814	Major facilitator Superfamily
AHiyo8_16450	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AHiyo8_16600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AHiyo8_16630	COG0822	iron-sulfur transferase activity
AHiyo8_16660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AHiyo8_16730	COG1215	transferase activity, transferring glycosyl groups
AHiyo8_16780	COG3979	chitinase
AHiyo8_16800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AHiyo8_16850	COG2197	response regulator
AHiyo8_16950	COG0193	aminoacyl-tRNA hydrolase activity
AHiyo8_16960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AHiyo8_16970	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AHiyo8_16980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AHiyo8_16990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AHiyo8_17000	COG1309	transcriptional regulator
AHiyo8_17020	COG0488	(ABC) transporter
AHiyo8_17030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AHiyo8_17040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AHiyo8_17050	COG3583	domain protein
AHiyo8_17060	COG0084	hydrolase, TatD family'
AHiyo8_17070	COG0714	Associated with various cellular activities
AHiyo8_17250	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AHiyo8_17420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AHiyo8_17430	COG1482	cell wall glycoprotein biosynthetic process
AHiyo8_17450	COG2826	transposase and inactivated derivatives, IS30 family
AHiyo8_17470	COG2826	transposase and inactivated derivatives, IS30 family
AHiyo8_17510	COG0288	reversible hydration of carbon dioxide
AHiyo8_17520	COG0114	fumarate hydratase activity
AHiyo8_17530	COG0114	fumarate hydratase activity
AHiyo8_17550	COG0477	Major facilitator Superfamily
AHiyo8_17560	COG2814	Major facilitator Superfamily
AHiyo8_17650	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AHiyo8_17660	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AHiyo8_17670	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AHiyo8_17720	COG1331	Highly conserved protein containing a thioredoxin domain
AHiyo8_17740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AHiyo8_17750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AHiyo8_17770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AHiyo8_17780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AHiyo8_17790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AHiyo8_17820	COG2017	converts alpha-aldose to the beta-anomer
AHiyo8_17840	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AHiyo8_17850	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AHiyo8_17870	COG0183	Belongs to the thiolase family
AHiyo8_17880	COG0183	Belongs to the thiolase family
AHiyo8_17890	COG0183	Belongs to the thiolase family
AHiyo8_17930	COG0410	ABC transporter
AHiyo8_17960	COG0559	Belongs to the binding-protein-dependent transport system permease family
AHiyo8_17990	COG1252	NADH dehydrogenase
AHiyo8_18000	COG1404	Belongs to the peptidase S8 family
AHiyo8_18050	COG0148	phosphopyruvate hydratase activity
AHiyo8_18060	COG0148	phosphopyruvate hydratase activity
AHiyo8_18080	COG3956	TIGRFAM MazG family protein
AHiyo8_18090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AHiyo8_18100	COG0586	Pfam SNARE associated Golgi protein
AHiyo8_18110	COG0586	Pfam SNARE associated Golgi protein
AHiyo8_18240	COG2130	NADP-dependent
AHiyo8_18250	COG2130	NADP-dependent
AHiyo8_18260	COG1764	response to oxidative stress
AHiyo8_18270	COG1846	Transcriptional regulator
AHiyo8_18280	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AHiyo8_18280	COG1473	amidohydrolase
AHiyo8_18290	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AHiyo8_18290	COG1473	amidohydrolase
AHiyo8_18310	COG2009	succinate dehydrogenase
AHiyo8_18340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AHiyo8_18400	COG0180	Tryptophanyl-tRNA synthetase
AHiyo8_18450	COG1131	(ABC) transporter
AHiyo8_18470	COG2197	response regulator
AHiyo8_18480	COG4585	Histidine kinase
AHiyo8_18490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AHiyo8_18500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AHiyo8_18510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AHiyo8_18590	COG0531	amino acid
AHiyo8_18600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AHiyo8_18640	COG1131	(ABC) transporter
AHiyo8_18700	COG1940	carbohydrate kinase activity
AHiyo8_18740	COG1129	ABC transporter
AHiyo8_18750	COG1129	ABC transporter
AHiyo8_18760	COG4214	carbohydrate transport
AHiyo8_18770	COG1172	Belongs to the binding-protein-dependent transport system permease family
AHiyo8_18790	COG0577	efflux transmembrane transporter activity
AHiyo8_18790	COG1136	(ABC) transporter
AHiyo8_18800	COG0577	efflux transmembrane transporter activity
AHiyo8_18800	COG1136	(ABC) transporter
AHiyo8_18810	COG1136	(ABC) transporter
AHiyo8_18870	COG0402	S-adenosylhomocysteine deaminase activity
AHiyo8_18940	COG2838	Isocitrate dehydrogenase
AHiyo8_18980	COG0138	bifunctional purine biosynthesis protein purh
AHiyo8_19010	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AHiyo8_19030	COG2814	Major facilitator Superfamily
AHiyo8_19030	COG0477	Major facilitator Superfamily
AHiyo8_19100	COG0179	Fumarylacetoacetate (FAA) hydrolase
AHiyo8_19120	COG0179	Fumarylacetoacetate (FAA) hydrolase
AHiyo8_19180	COG2814	Major facilitator Superfamily
AHiyo8_19200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AHiyo8_19210	COG2268	Band 7 protein
AHiyo8_19260	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AHiyo8_19270	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AHiyo8_19350	COG1116	anion transmembrane transporter activity
AHiyo8_19410	COG0577	efflux transmembrane transporter activity
AHiyo8_19410	COG1136	(ABC) transporter
AHiyo8_19460	COG1357	PFAM Pentapeptide repeats (8 copies)
AHiyo8_19620	COG2271	Major facilitator Superfamily
AHiyo8_19640	COG0477	Major facilitator Superfamily
AHiyo8_19650	COG3795	YCII-related domain
AHiyo8_19670	COG4941	Belongs to the sigma-70 factor family
AHiyo8_19700	COG2329	Antibiotic biosynthesis monooxygenase
AHiyo8_19770	COG2814	Major facilitator Superfamily
AHiyo8_20000	COG0667	Aldo Keto reductase
AHiyo8_20050	COG1116	anion transmembrane transporter activity
AHiyo8_20080	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AHiyo8_20110	COG0531	amino acid
AHiyo8_20220	COG0477	Major facilitator Superfamily
AHiyo8_20240	COG1309	transcriptional regulator
AHiyo8_20300	COG0640	Transcriptional regulator
AHiyo8_20350	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AHiyo8_20470	COG2271	Major facilitator Superfamily
AHiyo8_20480	COG2183	response to ionizing radiation
AHiyo8_20490	COG2183	response to ionizing radiation
AHiyo8_20550	COG1172	Belongs to the binding-protein-dependent transport system permease family
AHiyo8_20560	COG4214	carbohydrate transport
AHiyo8_20580	COG4213	ABC transporter substrate-binding protein
AHiyo8_20660	COG0149	triose-phosphate isomerase activity
AHiyo8_20720	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_20730	COG1250	3-hydroxyacyl-CoA dehydrogenase
AHiyo8_20730	COG1024	Enoyl-CoA hydratase
AHiyo8_20750	COG0698	ribose 5-phosphate isomerase
AHiyo8_20760	COG2376	Dihydroxyacetone kinase
AHiyo8_20810	COG1902	pentaerythritol trinitrate reductase activity
AHiyo8_20870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AHiyo8_20890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AHiyo8_20920	COG0156	8-amino-7-oxononanoate synthase activity
AHiyo8_20930	COG0156	8-amino-7-oxononanoate synthase activity
AHiyo8_21010	COG0463	Glycosyl transferase, family 2
AHiyo8_21050	COG1401	restriction endodeoxyribonuclease activity
AHiyo8_21090	COG0457	Tetratricopeptide repeat
AHiyo8_21170	COG0477	Major facilitator Superfamily
AHiyo8_21180	COG0477	Major facilitator Superfamily
AHiyo8_21200	COG0028	Belongs to the TPP enzyme family
AHiyo8_21290	COG1396	sequence-specific DNA binding
AHiyo8_21460	COG1760	l-serine dehydratase
AHiyo8_21470	COG1760	l-serine dehydratase
AHiyo8_21530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AHiyo8_21540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AHiyo8_21680	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AHiyo8_21750	COG4175	Glycine betaine
AHiyo8_21750	COG0517	IMP dehydrogenase activity
AHiyo8_21760	COG4176	ABC-type proline glycine betaine transport system permease component
AHiyo8_21770	COG4176	ABC-type proline glycine betaine transport system permease component
AHiyo8_21800	COG0477	Major facilitator Superfamily
AHiyo8_21810	COG0477	Major facilitator Superfamily
AHiyo8_21870	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AHiyo8_21920	COG3718	enzyme involved in inositol metabolism
AHiyo8_21930	COG0673	inositol 2-dehydrogenase activity
AHiyo8_21960	COG0673	inositol 2-dehydrogenase activity
AHiyo8_21980	COG0673	inositol 2-dehydrogenase activity
AHiyo8_21990	COG0673	inositol 2-dehydrogenase activity
AHiyo8_22040	COG1609	Transcriptional regulator
AHiyo8_22110	COG0659	secondary active sulfate transmembrane transporter activity
AHiyo8_22120	COG0673	inositol 2-dehydrogenase activity
AHiyo8_22130	COG0673	inositol 2-dehydrogenase activity
AHiyo8_22180	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo8_22200	COG3962	Belongs to the TPP enzyme family
AHiyo8_22260	COG0045	succinate-CoA ligase (ADP-forming) activity
AHiyo8_22320	COG0483	inositol monophosphate 1-phosphatase activity
AHiyo8_22380	COG2203	Gaf domain
AHiyo8_22380	COG5001	Diguanylate cyclase
AHiyo8_22380	COG4251	negative regulation of phosphorylation
AHiyo8_22380	COG3706	GGDEF domain
AHiyo8_22490	COG2205	protein histidine kinase activity
AHiyo8_22490	COG5002	protein histidine kinase activity
AHiyo8_22490	COG0784	Response regulator, receiver
AHiyo8_22510	COG3706	GGDEF domain
AHiyo8_22510	COG0745	RESPONSE REGULATOR receiver
AHiyo8_22520	COG3706	GGDEF domain
AHiyo8_22530	COG1132	(ABC) transporter
AHiyo8_22580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AHiyo8_22590	COG0765	amino acid transport
AHiyo8_22600	COG1126	abc transporter atp-binding protein
AHiyo8_22640	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AHiyo8_22730	COG0746	molybdenum cofactor guanylyltransferase activity
AHiyo8_22820	COG2814	Major facilitator Superfamily
AHiyo8_22850	COG1278	Cold shock
AHiyo8_22920	COG0583	DNA-binding transcription factor activity
AHiyo8_22950	COG0745	RESPONSE REGULATOR receiver
AHiyo8_22960	COG2205	protein histidine kinase activity
AHiyo8_22990	COG0459	protein refolding
AHiyo8_23050	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AHiyo8_23130	COG1760	l-serine dehydratase
AHiyo8_23140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AHiyo8_23150	COG0509	glycine decarboxylation via glycine cleavage system
AHiyo8_23160	COG0509	glycine decarboxylation via glycine cleavage system
AHiyo8_23180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AHiyo8_23190	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo8_23190	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo8_23200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo8_23200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHiyo8_23230	COG0477	Major facilitator Superfamily
AHiyo8_23250	COG0477	Major facilitator Superfamily
AHiyo8_23280	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AHiyo8_23310	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AHiyo8_23330	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AHiyo8_23360	COG1987	bacterial-type flagellum assembly
AHiyo8_23370	COG1338	Plays a role in the flagellum-specific transport system
AHiyo8_23470	COG3585	molybdate ion transport
AHiyo8_23500	COG1360	Flagellar Motor Protein
AHiyo8_23510	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AHiyo8_23530	COG0390	transport system, permease component
AHiyo8_23600	COG3842	ATPase activity
AHiyo8_23700	COG5002	protein histidine kinase activity
AHiyo8_23710	COG0745	RESPONSE REGULATOR receiver
AHiyo8_23740	COG0671	phosphoesterase, PA-phosphatase related
AHiyo8_23820	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AHiyo8_23830	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AHiyo8_23850	COG0531	amino acid
AHiyo8_23870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AHiyo8_23890	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AHiyo8_23900	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AHiyo8_23920	COG0656	L-ascorbic acid biosynthetic process
AHiyo8_24010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AHiyo8_24060	COG4786	Flagellar basal body rod
AHiyo8_24110	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AHiyo8_24170	COG1157	protein secretion by the type III secretion system
AHiyo8_24180	COG1157	protein secretion by the type III secretion system
AHiyo8_24210	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AHiyo8_24220	COG1766	The M ring may be actively involved in energy transduction
AHiyo8_24230	COG1677	Flagellar hook-basal body complex protein FliE
AHiyo8_24240	COG1558	bacterial-type flagellum-dependent cell motility
AHiyo8_24250	COG1815	bacterial-type flagellum-dependent cell motility
AHiyo8_24300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AHiyo8_24350	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AHiyo8_24360	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AHiyo8_24450	COG0483	inositol monophosphate 1-phosphatase activity
AHiyo8_24460	COG3842	ATPase activity
AHiyo8_24470	COG1116	anion transmembrane transporter activity
AHiyo8_24480	COG1177	transmembrane transport
AHiyo8_24540	COG0640	Transcriptional regulator
AHiyo8_24550	COG3832	glyoxalase III activity
AHiyo8_24580	COG4565	transcriptional regulatory protein
AHiyo8_24590	COG3290	protein histidine kinase activity
AHiyo8_24600	COG0154	amidase activity
AHiyo8_24610	COG0154	amidase activity
AHiyo8_24630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AHiyo8_24750	COG1335	isochorismatase
AHiyo8_24770	COG4166	transmembrane transport
AHiyo8_24820	COG4608	Belongs to the ABC transporter superfamily
AHiyo8_24830	COG0444	Belongs to the ABC transporter superfamily
AHiyo8_24850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AHiyo8_24880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AHiyo8_24890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AHiyo8_24900	COG0667	Aldo Keto reductase
AHiyo8_24910	COG0667	Aldo Keto reductase
AHiyo8_24990	COG1473	amidohydrolase
AHiyo8_25030	COG0671	phosphoesterase, PA-phosphatase related
AHiyo8_25040	COG3511	phospholipase C
AHiyo8_25080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AHiyo8_25120	COG3547	Transposase (IS116 IS110 IS902 family)
AHiyo8_25160	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AHiyo8_25230	COG1846	Transcriptional regulator
AHiyo8_25260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AHiyo8_25270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AHiyo8_25280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AHiyo8_25390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AHiyo8_25430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AHiyo8_25440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AHiyo8_25470	COG4974	Belongs to the 'phage' integrase family
AHiyo8_25520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AHiyo8_25550	COG0582	viral genome integration into host DNA
AHiyo8_25590	COG3842	ATPase activity
AHiyo8_25600	COG3842	ATPase activity
AHiyo8_25640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AHiyo8_25670	COG0601	transmembrane transport
AHiyo8_25680	COG0444	Belongs to the ABC transporter superfamily
AHiyo8_25690	COG4608	Belongs to the ABC transporter superfamily
AHiyo8_25700	COG0402	S-adenosylhomocysteine deaminase activity
AHiyo8_25740	COG0277	FAD linked oxidase domain protein
AHiyo8_25750	COG0277	FAD linked oxidase domain protein
AHiyo8_25790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AHiyo8_25810	COG3281	Trehalose synthase
AHiyo8_25850	COG0366	Alpha amylase catalytic
AHiyo8_25860	COG0366	Alpha amylase catalytic
AHiyo8_25870	COG0366	Alpha amylase catalytic
AHiyo8_25960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AHiyo8_25970	COG0215	cysteine-tRNA ligase activity
AHiyo8_25980	COG0215	cysteine-tRNA ligase activity
AHiyo8_25990	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AHiyo8_26000	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AHiyo8_26000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AHiyo8_26050	COG2801	Transposase and inactivated derivatives
AHiyo8_26080	COG0588	phosphoglycerate mutase activity
AHiyo8_26130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AHiyo8_26140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AHiyo8_26170	COG0596	Alpha beta hydrolase
AHiyo8_26340	COG3237	CsbD-like
AHiyo8_26370	COG0656	L-ascorbic acid biosynthetic process
AHiyo8_26430	COG0604	alcohol dehydrogenase
AHiyo8_26490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AHiyo8_26500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AHiyo8_26500	COG2146	nitrite reductase [NAD(P)H] activity
AHiyo8_26510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AHiyo8_26520	COG1968	undecaprenyl-diphosphatase activity
AHiyo8_26530	COG1968	undecaprenyl-diphosphatase activity
AHiyo8_26580	COG1505	serine-type exopeptidase activity
AHiyo8_26590	COG1505	serine-type exopeptidase activity
AHiyo8_26630	COG2814	Major facilitator Superfamily
AHiyo8_26640	COG0477	Major facilitator Superfamily
AHiyo8_26660	COG0514	ATP-dependent DNA helicase (RecQ)
AHiyo8_26680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AHiyo8_26720	COG3848	Pyruvate phosphate dikinase
AHiyo8_26720	COG0574	Belongs to the PEP-utilizing enzyme family
AHiyo8_26760	COG3848	Pyruvate phosphate dikinase
AHiyo8_26760	COG0574	Belongs to the PEP-utilizing enzyme family
AHiyo8_26770	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AHiyo8_26780	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AHiyo8_26810	COG2188	Transcriptional regulator
AHiyo8_26840	COG0601	transmembrane transport
AHiyo8_26850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AHiyo8_26860	COG0444	Belongs to the ABC transporter superfamily
AHiyo8_26870	COG4608	Belongs to the ABC transporter superfamily
AHiyo8_26920	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AHiyo8_26970	COG1511	domain protein
AHiyo8_26980	COG1309	transcriptional regulator
AHiyo8_27100	COG0745	RESPONSE REGULATOR receiver
AHiyo8_27110	COG2205	protein histidine kinase activity
AHiyo8_27120	COG2205	protein histidine kinase activity
AHiyo8_27180	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AHiyo8_27220	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AHiyo8_27240	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AHiyo8_27300	COG0363	glucosamine-6-phosphate deaminase activity
AHiyo8_27310	COG4821	SIS domain
AHiyo8_27320	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AHiyo8_27340	COG1609	Transcriptional regulator
AHiyo8_27380	COG0477	Major facilitator Superfamily
AHiyo8_27390	COG0477	Major facilitator Superfamily
AHiyo8_27410	COG1309	transcriptional regulator
AHiyo8_27430	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AHiyo8_27440	COG0590	tRNA wobble adenosine to inosine editing
AHiyo8_27550	COG1621	beta-fructofuranosidase activity
AHiyo8_27560	COG1621	beta-fructofuranosidase activity
AHiyo8_27630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AHiyo8_27650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AHiyo8_27780	COG1846	Transcriptional regulator
AHiyo8_27790	COG3547	Transposase (IS116 IS110 IS902 family)
AHiyo8_27860	COG0582	viral genome integration into host DNA
AHiyo8_27880	COG4974	Belongs to the 'phage' integrase family
AHiyo8_27940	COG3485	protocatechuate 3,4-dioxygenase
AHiyo8_27970	COG4948	Mandelate Racemase Muconate Lactonizing
AHiyo8_27990	COG0583	DNA-binding transcription factor activity
AHiyo8_28090	COG0569	domain protein
AHiyo8_28090	COG0475	glutathione-regulated potassium exporter activity
AHiyo8_28170	COG1201	RNA secondary structure unwinding
AHiyo8_28180	COG1201	RNA secondary structure unwinding
AHiyo8_28190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AHiyo8_28200	COG2364	Membrane
AHiyo8_28280	COG0564	pseudouridine synthase activity
AHiyo8_28320	COG0586	Pfam SNARE associated Golgi protein
AHiyo8_28340	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AHiyo8_28350	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AHiyo8_28360	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AHiyo8_28370	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AHiyo8_28390	COG0673	inositol 2-dehydrogenase activity
AHiyo8_28450	COG0673	inositol 2-dehydrogenase activity
AHiyo8_28460	COG1609	Transcriptional regulator
AHiyo8_28470	COG0477	Major facilitator Superfamily
AHiyo8_28480	COG3254	rhamnose metabolic process
AHiyo8_28490	COG1960	acyl-CoA dehydrogenase activity
AHiyo8_28590	COG0343	queuine tRNA-ribosyltransferase activity
AHiyo8_28630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AHiyo8_28700	COG1476	TRANSCRIPTIONal
AHiyo8_28870	COG0395	ABC-type sugar transport system, permease component
AHiyo8_28910	COG0673	inositol 2-dehydrogenase activity
AHiyo8_28950	COG0823	Involved in the tonB-independent uptake of proteins
AHiyo8_28960	COG4702	Belongs to the UPF0303 family
AHiyo8_28970	COG0477	Major facilitator Superfamily
AHiyo8_29000	COG1309	transcriptional regulator
AHiyo8_29130	COG0386	Belongs to the glutathione peroxidase family
AHiyo8_29140	COG0386	Belongs to the glutathione peroxidase family
AHiyo8_29150	COG0741	lytic transglycosylase activity
AHiyo8_29150	COG1196	nuclear chromosome segregation
AHiyo8_29150	COG0739	heme binding
AHiyo8_29210	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo8_29220	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo8_29260	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AHiyo8_29300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AHiyo8_29340	COG1131	(ABC) transporter
AHiyo8_29390	COG1846	Transcriptional regulator
AHiyo8_29460	COG1404	Belongs to the peptidase S8 family
AHiyo8_29500	COG0047	phosphoribosylformylglycinamidine synthase activity
AHiyo8_29510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AHiyo8_29520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AHiyo8_29630	COG2315	Protein conserved in bacteria
AHiyo8_29660	COG1832	CoA-binding protein
AHiyo8_29700	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AHiyo8_29770	COG0357	Ribosomal RNA small subunit methyltransferase G
AHiyo8_29770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AHiyo8_29810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AHiyo8_29850	COG0673	inositol 2-dehydrogenase activity
AHiyo8_29860	COG0673	inositol 2-dehydrogenase activity
AHiyo8_29880	COG0395	ABC-type sugar transport system, permease component
AHiyo8_29920	COG1609	Transcriptional regulator
AHiyo8_29940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AHiyo8_29970	COG1024	Enoyl-CoA hydratase
AHiyo8_30010	COG1024	Enoyl-CoA hydratase
AHiyo8_30040	COG0415	Belongs to the DNA photolyase family
AHiyo8_30050	COG0415	Belongs to the DNA photolyase family
AHiyo8_30080	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AHiyo8_30150	COG2197	response regulator
AHiyo8_30300	COG0366	Alpha amylase catalytic
AHiyo8_30370	COG1302	Protein conserved in bacteria
AHiyo8_30410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AHiyo8_30420	COG1609	Transcriptional regulator
AHiyo8_30480	COG3848	Pyruvate phosphate dikinase
AHiyo8_30480	COG0574	Belongs to the PEP-utilizing enzyme family
AHiyo8_30540	COG2252	PERMEase
AHiyo8_30550	COG2252	PERMEase
AHiyo8_30560	COG2252	PERMEase
AHiyo8_30570	COG0010	Belongs to the arginase family
AHiyo8_30590	COG0010	Belongs to the arginase family
AHiyo8_30680	COG3507	Belongs to the glycosyl hydrolase 43 family
AHiyo8_30730	COG2723	6-phospho-beta-galactosidase activity
AHiyo8_30790	COG0601	transmembrane transport
AHiyo8_30820	COG0747	negative chemotaxis
AHiyo8_30860	COG1309	transcriptional regulator
AHiyo8_30880	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_30890	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_30910	COG2186	Transcriptional regulator
AHiyo8_30930	COG2376	Dihydroxyacetone kinase
AHiyo8_30940	COG2376	Dihydroxyacetone kinase
AHiyo8_30950	COG0698	ribose 5-phosphate isomerase
AHiyo8_30960	COG0149	triose-phosphate isomerase activity
AHiyo8_30990	COG1082	Xylose isomerase domain protein TIM barrel
AHiyo8_31000	COG2084	Dehydrogenase
AHiyo8_31010	COG2902	Dehydrogenase
AHiyo8_31020	COG2902	Dehydrogenase
AHiyo8_31030	COG2902	Dehydrogenase
AHiyo8_31060	COG2986	histidine ammonia-lyase
AHiyo8_31070	COG2986	histidine ammonia-lyase
AHiyo8_31090	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AHiyo8_31120	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AHiyo8_31140	COG1113	amino acid transport
AHiyo8_31160	COG1113	amino acid transport
AHiyo8_31180	COG1280	lysine exporter protein (LysE YggA)
AHiyo8_31220	COG1609	Transcriptional regulator
AHiyo8_31230	COG0395	ABC-type sugar transport system, permease component
AHiyo8_31260	COG1175	transmembrane transport
AHiyo8_31310	COG3706	GGDEF domain
AHiyo8_31320	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_31480	COG2733	membrane
AHiyo8_31490	COG1984	allophanate hydrolase subunit 2
AHiyo8_31500	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AHiyo8_31560	COG1819	glycosyl
AHiyo8_31630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AHiyo8_31670	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AHiyo8_31740	COG1172	Belongs to the binding-protein-dependent transport system permease family
AHiyo8_31750	COG1129	ABC transporter
AHiyo8_31850	COG1349	DNA-binding transcription factor activity
AHiyo8_31860	COG1349	DNA-binding transcription factor activity
AHiyo8_31910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AHiyo8_31910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AHiyo8_31920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AHiyo8_31930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AHiyo8_31940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AHiyo8_31950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AHiyo8_32000	COG3237	CsbD-like
AHiyo8_32020	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AHiyo8_32080	COG2890	protein-(glutamine-N5) methyltransferase activity
AHiyo8_32090	COG0477	Major facilitator Superfamily
AHiyo8_32100	COG0477	Major facilitator Superfamily
AHiyo8_32110	COG0477	Major facilitator Superfamily
AHiyo8_32130	COG0745	RESPONSE REGULATOR receiver
AHiyo8_32140	COG5002	protein histidine kinase activity
AHiyo8_32150	COG0346	lactoylglutathione lyase activity
AHiyo8_32230	COG0542	response to heat
AHiyo8_32290	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_32300	COG4221	oxidoreductase activity
AHiyo8_32440	COG1982	Orn Lys Arg decarboxylase major
AHiyo8_32470	COG2610	gluconate transmembrane transporter activity
AHiyo8_32480	COG2084	Dehydrogenase
AHiyo8_32490	COG2084	Dehydrogenase
AHiyo8_32520	COG2186	Transcriptional regulator
AHiyo8_32540	COG2040	homocysteine
AHiyo8_32620	COG0833	amino acid
AHiyo8_32630	COG0833	amino acid
AHiyo8_32640	COG0460	homoserine dehydrogenase
AHiyo8_32650	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo8_32690	COG3360	Dodecin
AHiyo8_32730	COG0656	L-ascorbic acid biosynthetic process
AHiyo8_32740	COG0667	Aldo Keto reductase
AHiyo8_32760	COG0656	L-ascorbic acid biosynthetic process
AHiyo8_32820	COG1796	DNA polymerase
AHiyo8_32820	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AHiyo8_32830	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AHiyo8_32840	COG0829	nickel cation binding
AHiyo8_32850	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AHiyo8_32860	COG0830	nickel cation binding
AHiyo8_32870	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AHiyo8_32880	COG0804	urea catabolic process
AHiyo8_32890	COG0804	urea catabolic process
AHiyo8_32900	COG0804	urea catabolic process
AHiyo8_32910	COG0804	urea catabolic process
AHiyo8_32920	COG0832	Belongs to the urease beta subunit family
AHiyo8_32930	COG0831	urea catabolic process
AHiyo8_32940	COG0586	Pfam SNARE associated Golgi protein
AHiyo8_32950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AHiyo8_32990	COG0306	phosphate transporter
AHiyo8_33000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AHiyo8_33010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AHiyo8_33040	COG0573	inorganic phosphate transmembrane transporter activity
AHiyo8_33100	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AHiyo8_33110	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AHiyo8_33150	COG2226	methyltransferase
AHiyo8_33190	COG1461	Dihydroxyacetone kinase
AHiyo8_33210	COG2376	Dihydroxyacetone kinase
AHiyo8_33220	COG2376	Dihydroxyacetone kinase
AHiyo8_33240	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AHiyo8_33250	COG0823	Involved in the tonB-independent uptake of proteins
AHiyo8_33250	COG1506	peptidase
AHiyo8_33260	COG0542	response to heat
AHiyo8_33270	COG0542	response to heat
AHiyo8_33290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AHiyo8_33300	COG0596	Alpha beta hydrolase
AHiyo8_33370	COG0477	Major facilitator Superfamily
AHiyo8_33380	COG0477	Major facilitator Superfamily
AHiyo8_33390	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AHiyo8_33400	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AHiyo8_33460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AHiyo8_33480	COG0302	gtp cyclohydrolase
AHiyo8_33490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AHiyo8_33510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AHiyo8_33590	COG0037	tRNA processing
AHiyo8_33710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AHiyo8_33720	COG1597	lipid kinase activity
AHiyo8_33750	COG0425	Belongs to the sulfur carrier protein TusA family
AHiyo8_33750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AHiyo8_33760	COG3340	Belongs to the peptidase S51 family
AHiyo8_33770	COG0154	amidase activity
AHiyo8_33800	COG0154	amidase activity
AHiyo8_33810	COG3104	oligopeptide transport
AHiyo8_33860	COG0778	Nitroreductase
AHiyo8_33870	COG2233	PERMEase
AHiyo8_33890	COG1929	Belongs to the glycerate kinase type-1 family
AHiyo8_33910	COG4941	Belongs to the sigma-70 factor family
AHiyo8_33970	COG2197	response regulator
AHiyo8_33980	COG0561	phosphatase activity
AHiyo8_34050	COG0659	secondary active sulfate transmembrane transporter activity
AHiyo8_34060	COG0659	secondary active sulfate transmembrane transporter activity
AHiyo8_34070	COG0385	Bile acid
AHiyo8_34090	COG0385	Bile acid
AHiyo8_34100	COG1609	Transcriptional regulator
AHiyo8_34300	COG0165	Argininosuccinate lyase
AHiyo8_34350	COG4770	biotin carboxylase activity
AHiyo8_34360	COG4770	biotin carboxylase activity
AHiyo8_34370	COG1984	allophanate hydrolase subunit 2
AHiyo8_34380	COG1984	allophanate hydrolase subunit 2
AHiyo8_34400	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AHiyo8_34490	COG1716	ATPase activity
AHiyo8_34510	COG0631	protein serine/threonine phosphatase activity
AHiyo8_34530	COG0772	Belongs to the SEDS family
AHiyo8_34560	COG0768	penicillin binding
AHiyo8_34580	COG0515	serine threonine protein kinase
AHiyo8_34600	COG0515	serine threonine protein kinase
AHiyo8_34610	COG2815	serine threonine protein kinase
AHiyo8_34610	COG0515	serine threonine protein kinase
AHiyo8_34670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AHiyo8_34690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AHiyo8_34700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AHiyo8_34700	COG2169	Transcriptional regulator
AHiyo8_34710	COG3145	DNA-N1-methyladenine dioxygenase activity
AHiyo8_34720	COG2818	Glycosylase
AHiyo8_34830	COG1215	transferase activity, transferring glycosyl groups
AHiyo8_34860	COG3266	domain, Protein
AHiyo8_34870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AHiyo8_34880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AHiyo8_34890	COG0187	DNA topoisomerase II activity
AHiyo8_34900	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AHiyo8_34920	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AHiyo8_34930	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AHiyo8_34950	COG0592	DNA-directed DNA polymerase activity
AHiyo8_34970	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AHiyo8_34980	COG0594	ribonuclease P activity
AHiyo8_34990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AHiyo8_35000	COG0706	membrane insertase activity
AHiyo8_35020	COG0357	Ribosomal RNA small subunit methyltransferase G
AHiyo8_35030	COG1192	Involved in chromosome partitioning
AHiyo8_35050	COG3118	belongs to the thioredoxin family
AHiyo8_35060	COG0492	ferredoxin-NADP+ reductase activity
AHiyo8_35120	COG0617	tRNA 3'-terminal CCA addition
AHiyo8_35130	COG0406	alpha-ribazole phosphatase activity
AHiyo8_35190	COG2910	NAD(P)H-binding
AHiyo8_35200	COG1733	regulation of RNA biosynthetic process
AHiyo8_35220	COG1136	(ABC) transporter
AHiyo8_35220	COG0577	efflux transmembrane transporter activity
AHiyo8_35240	COG4585	Histidine kinase
AHiyo8_35250	COG2197	response regulator
AHiyo8_35270	COG0768	penicillin binding
AHiyo8_35310	COG1309	transcriptional regulator
AHiyo8_35320	COG0488	(ABC) transporter
AHiyo8_35350	COG0738	Major facilitator superfamily
AHiyo8_35380	COG0577	efflux transmembrane transporter activity
AHiyo8_35390	COG0577	efflux transmembrane transporter activity
AHiyo8_35390	COG1136	(ABC) transporter
AHiyo8_35470	COG1131	(ABC) transporter
AHiyo8_35480	COG1131	(ABC) transporter
AHiyo8_35520	COG4585	Histidine kinase
AHiyo8_35530	COG2197	response regulator
AHiyo8_35540	COG1362	aminopeptidase activity
AHiyo8_35570	COG1742	UPF0060 membrane protein
AHiyo8_35580	COG1742	UPF0060 membrane protein
AHiyo8_35590	COG0360	Binds together with S18 to 16S ribosomal RNA
AHiyo8_35620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AHiyo8_35630	COG0359	binds to the 23S rRNA
AHiyo8_35690	COG0305	Participates in initiation and elongation during chromosome replication
AHiyo8_35700	COG0305	Participates in initiation and elongation during chromosome replication
AHiyo8_35730	COG1607	acyl-coa hydrolase
AHiyo8_35740	COG2259	Doxx family
AHiyo8_35830	COG2217	Heavy metal translocating P-type atpase
AHiyo8_35890	COG1937	Protein conserved in bacteria
AHiyo8_35940	COG0395	ABC-type sugar transport system, permease component
AHiyo8_35960	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AHiyo8_35970	COG1414	Transcriptional regulator
AHiyo8_35990	COG4251	negative regulation of phosphorylation
AHiyo8_35990	COG5001	Diguanylate cyclase
AHiyo8_35990	COG2203	Gaf domain
AHiyo8_35990	COG3706	GGDEF domain
AHiyo8_36010	COG0251	oxidation-reduction process
AHiyo8_36030	COG1414	Transcriptional regulator
AHiyo8_36060	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AHiyo8_36080	COG2610	gluconate transmembrane transporter activity
AHiyo8_36130	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AHiyo8_36150	COG0477	Major facilitator Superfamily
AHiyo8_36160	COG1414	Transcriptional regulator
AHiyo8_36170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AHiyo8_36180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AHiyo8_36210	COG3485	protocatechuate 3,4-dioxygenase
AHiyo8_36250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AHiyo8_36260	COG0183	Belongs to the thiolase family
AHiyo8_36270	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AHiyo8_36280	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AHiyo8_36310	COG1414	Transcriptional regulator
AHiyo8_36370	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AHiyo8_36390	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AHiyo8_36400	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AHiyo8_36500	COG1278	Cold shock
AHiyo8_36580	COG2271	Major facilitator Superfamily
AHiyo8_36620	COG1104	cysteine desulfurase activity
AHiyo8_36630	COG0506	proline dehydrogenase activity
AHiyo8_36660	COG1970	mechanosensitive ion channel activity
AHiyo8_36710	COG1414	Transcriptional regulator
AHiyo8_36740	COG2017	converts alpha-aldose to the beta-anomer
AHiyo8_36750	COG1940	carbohydrate kinase activity
AHiyo8_36760	COG0277	FAD linked oxidase domain protein
AHiyo8_36770	COG0277	FAD linked oxidase domain protein
AHiyo8_36780	COG2115	Belongs to the xylose isomerase family
AHiyo8_36790	COG2115	Belongs to the xylose isomerase family
AHiyo8_36800	COG1070	Carbohydrate kinase
AHiyo8_36810	COG1070	Carbohydrate kinase
AHiyo8_36840	COG1940	carbohydrate kinase activity
AHiyo8_36900	COG0673	inositol 2-dehydrogenase activity
AHiyo8_36940	COG1175	transmembrane transport
AHiyo8_36960	COG1653	transport
AHiyo8_37060	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AHiyo8_37080	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AHiyo8_37090	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AHiyo8_37100	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AHiyo8_37110	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AHiyo8_37200	COG1132	(ABC) transporter
AHiyo8_37210	COG1132	(ABC) transporter
AHiyo8_37220	COG1132	(ABC) transporter
AHiyo8_37370	COG1802	Transcriptional regulator
AHiyo8_37400	COG3971	2-oxopent-4-enoate hydratase activity
AHiyo8_37460	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AHiyo8_37480	COG0583	DNA-binding transcription factor activity
AHiyo8_37490	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AHiyo8_37500	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AHiyo8_37550	COG0477	Major facilitator Superfamily
AHiyo8_37570	COG4221	oxidoreductase activity
AHiyo8_37580	COG1607	acyl-coa hydrolase
AHiyo8_37630	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AHiyo8_37660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AHiyo8_37690	COG0022	dehydrogenase e1 component
AHiyo8_37700	COG0022	dehydrogenase e1 component
AHiyo8_37710	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHiyo8_37760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AHiyo8_37810	COG1309	transcriptional regulator
AHiyo8_37820	COG0673	inositol 2-dehydrogenase activity
AHiyo8_37830	COG0673	inositol 2-dehydrogenase activity
AHiyo8_37880	COG0686	Belongs to the AlaDH PNT family
AHiyo8_37890	COG0686	Belongs to the AlaDH PNT family
AHiyo8_38020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AHiyo8_38040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AHiyo8_38060	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AHiyo8_38060	COG2213	PTS system mannitol-specific
AHiyo8_38070	COG0246	Mannitol dehydrogenase
AHiyo8_38080	COG0246	Mannitol dehydrogenase
AHiyo8_38090	COG1846	Transcriptional regulator
AHiyo8_38120	COG1113	amino acid transport
AHiyo8_38150	COG2814	Major facilitator Superfamily
AHiyo8_38160	COG2814	Major facilitator Superfamily
AHiyo8_38170	COG0477	Major facilitator Superfamily
AHiyo8_38180	COG0477	Major facilitator Superfamily
AHiyo8_38200	COG0477	Major facilitator Superfamily
AHiyo8_38220	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AHiyo8_38230	COG2211	Major facilitator Superfamily
AHiyo8_38250	COG1309	transcriptional regulator
AHiyo8_38270	COG0281	malic enzyme
AHiyo8_38280	COG4585	Histidine kinase
AHiyo8_38290	COG2197	response regulator
AHiyo8_38320	COG1280	lysine exporter protein (LysE YggA)
AHiyo8_38330	COG1522	sequence-specific DNA binding
AHiyo8_38390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AHiyo8_38510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AHiyo8_38520	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_38540	COG4948	Mandelate Racemase Muconate Lactonizing
AHiyo8_38550	COG4948	Mandelate Racemase Muconate Lactonizing
AHiyo8_38570	COG1172	Belongs to the binding-protein-dependent transport system permease family
AHiyo8_38600	COG3254	rhamnose metabolic process
AHiyo8_38630	COG2186	Transcriptional regulator
AHiyo8_38650	COG1027	Aspartate ammonia-lyase
AHiyo8_38690	COG4115	mRNA cleavage
AHiyo8_38700	COG2161	toxin-antitoxin pair type II binding
AHiyo8_38780	COG0667	Aldo Keto reductase
AHiyo8_38810	COG3012	SEC-C Motif Domain Protein
AHiyo8_38930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AHiyo8_38940	COG1120	ATPase activity
AHiyo8_39040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AHiyo8_39040	COG1017	nitric oxide dioxygenase activity
AHiyo8_39050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AHiyo8_39060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AHiyo8_39070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AHiyo8_39080	COG0776	regulation of translation
AHiyo8_39150	COG0433	COG0433 Predicted ATPase
AHiyo8_39160	COG2318	DinB family
AHiyo8_39200	COG1126	abc transporter atp-binding protein
AHiyo8_39280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AHiyo8_39290	COG0488	(ABC) transporter
AHiyo8_39370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AHiyo8_39390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AHiyo8_39400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AHiyo8_39430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AHiyo8_39460	COG3387	PFAM Glycoside hydrolase 15-related
AHiyo8_39480	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AHiyo8_39490	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AHiyo8_39510	COG1309	transcriptional regulator
AHiyo8_39530	COG0583	DNA-binding transcription factor activity
AHiyo8_39610	COG0717	Belongs to the dCTP deaminase family
AHiyo8_39620	COG0717	Belongs to the dCTP deaminase family
AHiyo8_39630	COG0475	glutathione-regulated potassium exporter activity
AHiyo8_39650	COG0490	domain, Protein
AHiyo8_39650	COG2985	domain, Protein
AHiyo8_39660	COG0363	glucosamine-6-phosphate deaminase activity
AHiyo8_39670	COG1472	Belongs to the glycosyl hydrolase 3 family
AHiyo8_39710	COG2111	Na H antiporter
AHiyo8_39710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AHiyo8_39720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AHiyo8_39720	COG2111	Na H antiporter
AHiyo8_39760	COG2212	antiporter activity
AHiyo8_39770	COG1320	monovalent cation:proton antiporter activity
AHiyo8_39800	COG4721	ABC-type cobalt transport system, permease component
AHiyo8_39810	COG4172	Belongs to the ABC transporter superfamily
AHiyo8_39820	COG1122	ATPase activity
AHiyo8_39840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AHiyo8_39870	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AHiyo8_39880	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AHiyo8_39890	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AHiyo8_40090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AHiyo8_40100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AHiyo8_40160	COG1953	Uracil, thiamine, allantoin
AHiyo8_40190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AHiyo8_40190	COG0512	Glutamine amidotransferase of anthranilate synthase
AHiyo8_40210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AHiyo8_40220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AHiyo8_40230	COG2814	Major facilitator Superfamily
AHiyo8_40240	COG1957	nucleoside hydrolase
AHiyo8_40250	COG1609	Transcriptional regulator
AHiyo8_40270	COG1280	lysine exporter protein (LysE YggA)
AHiyo8_40320	COG4941	Belongs to the sigma-70 factor family
AHiyo8_40330	COG3795	YCII-related domain
AHiyo8_40340	COG2226	methyltransferase
AHiyo8_40580	COG1846	Transcriptional regulator
AHiyo8_40590	COG2409	Drug exporters of the RND superfamily
AHiyo8_40600	COG2409	Drug exporters of the RND superfamily
AHiyo8_40640	COG3739	integral membrane protein
AHiyo8_40650	COG0443	Heat shock 70 kDa protein
AHiyo8_40660	COG0443	Heat shock 70 kDa protein
AHiyo8_40670	COG0443	Heat shock 70 kDa protein
AHiyo8_40680	COG0443	Heat shock 70 kDa protein
AHiyo8_40690	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AHiyo8_40700	COG0484	heat shock protein binding
AHiyo8_40710	COG0484	heat shock protein binding
AHiyo8_40720	COG0789	Transcriptional regulator
AHiyo8_40790	COG0179	Fumarylacetoacetate (FAA) hydrolase
AHiyo8_40800	COG0179	Fumarylacetoacetate (FAA) hydrolase
AHiyo8_40810	COG0251	oxidation-reduction process
AHiyo8_40840	COG0765	amino acid transport
AHiyo8_40940	COG0765	amino acid transport
AHiyo8_40960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AHiyo8_40980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AHiyo8_41080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AHiyo8_41090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AHiyo8_41100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AHiyo8_41110	COG2807	transmembrane transport
AHiyo8_41130	COG0477	Major facilitator Superfamily
AHiyo8_41270	COG0667	Aldo Keto reductase
AHiyo8_41280	COG0667	Aldo Keto reductase
AHiyo8_41290	COG2076	Multidrug Resistance protein
AHiyo8_41300	COG2076	Multidrug Resistance protein
AHiyo8_41330	COG0135	phosphoribosylanthranilate isomerase activity
AHiyo8_41340	COG0135	phosphoribosylanthranilate isomerase activity
AHiyo8_41380	COG1793	dna ligase
AHiyo8_41390	COG3304	Inner membrane component domain
AHiyo8_41410	COG0028	Belongs to the TPP enzyme family
AHiyo8_41420	COG0028	Belongs to the TPP enzyme family
AHiyo8_41580	COG0542	response to heat
AHiyo8_41650	COG0765	amino acid transport
AHiyo8_41660	COG0765	amino acid transport
AHiyo8_41670	COG1116	anion transmembrane transporter activity
AHiyo8_41690	COG0640	Transcriptional regulator
AHiyo8_41720	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AHiyo8_41780	COG2186	Transcriptional regulator
AHiyo8_41790	COG0174	glutamine synthetase
AHiyo8_41810	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AHiyo8_41840	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo8_41850	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo8_41880	COG2351	hydroxyisourate hydrolase activity
AHiyo8_41920	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AHiyo8_41950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AHiyo8_41960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AHiyo8_41980	COG1929	Belongs to the glycerate kinase type-1 family
AHiyo8_42000	COG3960	tartronate-semialdehyde synthase activity
AHiyo8_42010	COG3960	tartronate-semialdehyde synthase activity
AHiyo8_42040	COG3622	Belongs to the hyi family
AHiyo8_42090	COG1116	anion transmembrane transporter activity
AHiyo8_42120	COG1136	(ABC) transporter
AHiyo8_42180	COG1301	dicarboxylic acid transport
AHiyo8_42190	COG1301	dicarboxylic acid transport
AHiyo8_42210	COG0583	DNA-binding transcription factor activity
AHiyo8_42230	COG2040	homocysteine
AHiyo8_42390	COG2986	histidine ammonia-lyase
AHiyo8_42400	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AHiyo8_42410	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AHiyo8_42420	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AHiyo8_42570	COG2267	carboxylic ester hydrolase activity
AHiyo8_42670	COG2971	BadF BadG BcrA BcrD
AHiyo8_42770	COG1175	transmembrane transport
AHiyo8_42800	COG1609	Transcriptional regulator
AHiyo8_42840	COG0698	ribose 5-phosphate isomerase
AHiyo8_42850	COG2376	Dihydroxyacetone kinase
AHiyo8_42860	COG2376	Dihydroxyacetone kinase
AHiyo8_42870	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_42890	COG1082	Xylose isomerase domain protein TIM barrel
AHiyo8_42900	COG0477	Major facilitator Superfamily
AHiyo8_42910	COG0477	Major facilitator Superfamily
AHiyo8_42920	COG3959	Transketolase, thiamine diphosphate binding domain
AHiyo8_42930	COG3958	Transketolase
AHiyo8_42940	COG3958	Transketolase
AHiyo8_42960	COG2337	Toxic component of a toxin-antitoxin (TA) module
AHiyo8_43000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AHiyo8_43080	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_43110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AHiyo8_43120	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AHiyo8_43130	COG2084	Dehydrogenase
AHiyo8_43160	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_43400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AHiyo8_43400	COG4499	WXG100 protein secretion system (Wss), protein YukC
AHiyo8_43420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AHiyo8_43430	COG0563	adenylate kinase activity
AHiyo8_43440	COG3387	PFAM Glycoside hydrolase 15-related
AHiyo8_43450	COG3387	PFAM Glycoside hydrolase 15-related
AHiyo8_43460	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AHiyo8_43470	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AHiyo8_43510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AHiyo8_43540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AHiyo8_43550	COG3257	ureidoglycine aminohydrolase activity
AHiyo8_43610	COG1414	Transcriptional regulator
AHiyo8_43620	COG1953	Uracil, thiamine, allantoin
AHiyo8_43630	COG1953	Uracil, thiamine, allantoin
AHiyo8_43660	COG2233	PERMEase
AHiyo8_43760	COG2252	PERMEase
AHiyo8_43770	COG2252	PERMEase
AHiyo8_43820	COG2080	2 iron, 2 sulfur cluster binding
AHiyo8_43840	COG2080	2 iron, 2 sulfur cluster binding
AHiyo8_43840	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AHiyo8_43880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AHiyo8_43890	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AHiyo8_43900	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AHiyo8_43930	COG1953	Uracil, thiamine, allantoin
AHiyo8_43950	COG1953	Uracil, thiamine, allantoin
AHiyo8_43980	COG2066	Belongs to the glutaminase family
AHiyo8_44040	COG1982	Orn Lys Arg decarboxylase major
AHiyo8_44050	COG1301	dicarboxylic acid transport
AHiyo8_44060	COG1301	dicarboxylic acid transport
AHiyo8_44130	COG0151	Belongs to the GarS family
AHiyo8_44140	COG0151	Belongs to the GarS family
AHiyo8_44150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AHiyo8_44180	COG1132	(ABC) transporter
AHiyo8_44200	COG1132	(ABC) transporter
AHiyo8_44210	COG1408	metallophosphoesterase
AHiyo8_44240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AHiyo8_44290	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AHiyo8_44330	COG0395	ABC-type sugar transport system, permease component
AHiyo8_44390	COG1609	Transcriptional regulator
AHiyo8_44400	COG1609	Transcriptional regulator
AHiyo8_44410	COG1349	DNA-binding transcription factor activity
AHiyo8_44500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AHiyo8_44510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AHiyo8_44530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AHiyo8_44710	COG1111	helicase
AHiyo8_44710	COG1205	dead DEAH box helicase
AHiyo8_44760	COG2890	protein-(glutamine-N5) methyltransferase activity
AHiyo8_44790	COG1754	DNA topoisomerase type I activity
AHiyo8_44790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AHiyo8_44800	COG1754	DNA topoisomerase type I activity
AHiyo8_44800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AHiyo8_44830	COG0248	Ppx GppA phosphatase
AHiyo8_44840	COG1082	Xylose isomerase domain protein TIM barrel
AHiyo8_44850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AHiyo8_44860	COG0569	domain protein
AHiyo8_44870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AHiyo8_44880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AHiyo8_44890	COG0123	including yeast histone deacetylase and acetoin utilization protein
AHiyo8_44910	COG0640	Transcriptional regulator
AHiyo8_44960	COG1609	Transcriptional regulator
AHiyo8_44970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AHiyo8_45000	COG0560	Phosphoserine phosphatase
AHiyo8_45030	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AHiyo8_45080	COG0406	alpha-ribazole phosphatase activity
AHiyo8_45090	COG0406	alpha-ribazole phosphatase activity
AHiyo8_45110	COG0785	Cytochrome C biogenesis protein
AHiyo8_45150	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AHiyo8_45210	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AHiyo8_45250	COG1266	CAAX protease self-immunity
AHiyo8_45270	COG1113	amino acid transport
AHiyo8_45280	COG1113	amino acid transport
AHiyo8_45290	COG1113	amino acid transport
AHiyo8_45310	COG0412	Dienelactone hydrolase
AHiyo8_45340	COG0183	Belongs to the thiolase family
AHiyo8_45360	COG1024	Enoyl-CoA hydratase
AHiyo8_45370	COG1024	Enoyl-CoA hydratase
AHiyo8_45370	COG1250	3-hydroxyacyl-CoA dehydrogenase
AHiyo8_45390	COG1250	3-hydroxyacyl-CoA dehydrogenase
AHiyo8_45440	COG0673	inositol 2-dehydrogenase activity
AHiyo8_45500	COG1609	Transcriptional regulator
AHiyo8_45520	COG2030	dehydratase
AHiyo8_45520	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo8_45570	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AHiyo8_45580	COG2050	protein possibly involved in aromatic compounds catabolism
AHiyo8_45630	COG0745	RESPONSE REGULATOR receiver
AHiyo8_45650	COG5002	protein histidine kinase activity
AHiyo8_45720	COG1316	TRANSCRIPTIONal
AHiyo8_45780	COG3848	Pyruvate phosphate dikinase
AHiyo8_45780	COG0574	Belongs to the PEP-utilizing enzyme family
AHiyo8_45800	COG0574	Belongs to the PEP-utilizing enzyme family
AHiyo8_45800	COG3848	Pyruvate phosphate dikinase
AHiyo8_45850	COG2894	cell division
AHiyo8_45870	COG4962	Type ii secretion system protein e
AHiyo8_45940	COG0745	RESPONSE REGULATOR receiver
AHiyo8_45950	COG0745	RESPONSE REGULATOR receiver
AHiyo8_45980	COG5002	protein histidine kinase activity
AHiyo8_46020	COG3396	Phenylacetate-CoA oxygenase
AHiyo8_46030	COG3396	Phenylacetate-CoA oxygenase
AHiyo8_46040	COG3460	Phenylacetate-CoA oxygenase
AHiyo8_46050	COG3396	Phenylacetate-CoA oxygenase
AHiyo8_46060	COG2151	metal-sulfur cluster biosynthetic enzyme
AHiyo8_46070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AHiyo8_46190	COG0640	Transcriptional regulator
AHiyo8_46270	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AHiyo8_46310	COG3706	GGDEF domain
AHiyo8_46310	COG2203	Gaf domain
AHiyo8_46310	COG4251	negative regulation of phosphorylation
AHiyo8_46310	COG5001	Diguanylate cyclase
AHiyo8_46340	COG2826	transposase and inactivated derivatives, IS30 family
AHiyo8_46350	COG2826	transposase and inactivated derivatives, IS30 family
AHiyo8_46420	COG0745	RESPONSE REGULATOR receiver
AHiyo8_46480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AHiyo8_46490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AHiyo8_46540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AHiyo8_46640	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AHiyo8_46650	COG4974	Belongs to the 'phage' integrase family
AHiyo8_46690	COG2826	transposase and inactivated derivatives, IS30 family
AHiyo8_46700	COG4974	Belongs to the 'phage' integrase family
AHiyo8_46710	COG4974	Belongs to the 'phage' integrase family
AHiyo8_46730	COG4974	Belongs to the 'phage' integrase family
AHiyo8_46770	COG0489	protein tyrosine kinase activity
AHiyo8_46770	COG3206	protein involved in exopolysaccharide biosynthesis
AHiyo8_46780	COG0489	protein tyrosine kinase activity
AHiyo8_46830	COG0022	dehydrogenase e1 component
AHiyo8_46840	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHiyo8_46850	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHiyo8_46860	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHiyo8_46970	COG2197	response regulator
AHiyo8_47020	COG1309	transcriptional regulator
AHiyo8_47030	COG2200	EAL domain
AHiyo8_47030	COG2199	diguanylate cyclase activity
AHiyo8_47030	COG3287	FIST C domain
AHiyo8_47190	COG0640	Transcriptional regulator
AHiyo8_47200	COG2826	transposase and inactivated derivatives, IS30 family
AHiyo8_47210	COG2826	transposase and inactivated derivatives, IS30 family
AHiyo8_47230	COG3979	chitinase
AHiyo8_47280	COG0702	epimerase
AHiyo8_47290	COG0702	epimerase
AHiyo8_47300	COG1349	DNA-binding transcription factor activity
AHiyo8_47310	COG0640	Transcriptional regulator
AHiyo8_47390	COG0800	Aldolase
AHiyo8_47400	COG2271	Major facilitator Superfamily
AHiyo8_47410	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AHiyo8_47590	COG1175	transmembrane transport
AHiyo8_47600	COG0395	ABC-type sugar transport system, permease component
AHiyo8_47660	COG4948	Mandelate Racemase Muconate Lactonizing
AHiyo8_47670	COG4948	Mandelate Racemase Muconate Lactonizing
AHiyo8_47700	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AHiyo8_47710	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AHiyo8_47720	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AHiyo8_47730	COG1126	abc transporter atp-binding protein
AHiyo8_47750	COG0765	amino acid transport
AHiyo8_47770	COG1169	isochorismate synthase
AHiyo8_47780	COG2226	methyltransferase
AHiyo8_47790	COG0644	oxidoreductase
AHiyo8_47850	COG2860	membrane
AHiyo8_47870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AHiyo8_47880	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AHiyo8_47950	COG1116	anion transmembrane transporter activity
AHiyo8_47970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AHiyo8_47980	COG1648	precorrin-2 dehydrogenase activity
AHiyo8_47980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AHiyo8_47990	COG1648	precorrin-2 dehydrogenase activity
AHiyo8_47990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AHiyo8_48010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AHiyo8_48010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AHiyo8_48020	COG2186	Transcriptional regulator
AHiyo8_48050	COG2508	Transcriptional regulator
AHiyo8_48050	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AHiyo8_48090	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo8_48100	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo8_48140	COG0493	'glutamate synthase
AHiyo8_48150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AHiyo8_48150	COG0493	'glutamate synthase
AHiyo8_48250	COG1012	belongs to the aldehyde dehydrogenase family
AHiyo8_48280	COG0531	amino acid
AHiyo8_48290	COG0531	amino acid
AHiyo8_48320	COG0753	catalase activity
AHiyo8_48340	COG0531	amino acid
AHiyo8_48350	COG0501	Belongs to the peptidase M48B family
AHiyo8_48370	COG2837	iron assimilation
AHiyo8_48400	COG0672	)-iron permease
AHiyo8_48420	COG1666	GTP binding
AHiyo8_48440	COG0582	viral genome integration into host DNA
AHiyo8_48710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AHiyo8_48730	COG0318	PFAM AMP-dependent synthetase and ligase
AHiyo8_48740	COG0318	PFAM AMP-dependent synthetase and ligase
AHiyo8_48870	COG1733	regulation of RNA biosynthetic process
AHiyo8_49200	COG3511	phospholipase C
AHiyo8_49360	COG1215	transferase activity, transferring glycosyl groups
AHiyo8_49440	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AHiyo8_49470	COG0745	RESPONSE REGULATOR receiver
AHiyo8_49480	COG0745	RESPONSE REGULATOR receiver
AHiyo8_49500	COG2205	protein histidine kinase activity
AHiyo8_49520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AHiyo8_49560	COG3547	Transposase (IS116 IS110 IS902 family)
AHiyo8_49570	COG3547	Transposase (IS116 IS110 IS902 family)
AHiyo8_49640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AHiyo8_49700	COG1846	Transcriptional regulator
AHiyo8_49810	COG3942	CHAP domain
AHiyo8_49810	COG1388	LysM domain
AHiyo8_49850	COG1940	carbohydrate kinase activity
AHiyo8_49910	COG4989	oxidoreductase activity
AHiyo8_49950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AHiyo8_50020	COG2030	dehydratase
AHiyo8_50040	COG0738	Major facilitator superfamily
AHiyo8_50050	COG0738	Major facilitator superfamily
AHiyo8_50060	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AHiyo8_50100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AHiyo8_50130	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AHiyo8_50160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AHiyo8_50170	COG0456	acetyltransferase
AHiyo8_50180	COG0745	RESPONSE REGULATOR receiver
AHiyo8_50220	COG3485	protocatechuate 3,4-dioxygenase
AHiyo8_50230	COG3485	protocatechuate 3,4-dioxygenase
AHiyo8_50250	COG0354	folic acid binding
AHiyo8_50400	COG2197	response regulator
AHiyo8_50410	COG0436	Aminotransferase
AHiyo8_50450	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AHiyo8_50460	COG0081	regulation of translation
AHiyo8_50510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AHiyo8_50520	COG0222	ribosome binding
AHiyo8_50530	COG0442	prolyl-tRNA aminoacylation
AHiyo8_50540	COG0183	Belongs to the thiolase family
AHiyo8_50550	COG0085	RNA polymerase activity
AHiyo8_50560	COG0085	RNA polymerase activity
AHiyo8_50570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AHiyo8_50580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AHiyo8_50590	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AHiyo8_50600	COG0049	tRNA binding
AHiyo8_50610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AHiyo8_50620	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AHiyo8_50720	COG0051	transcription antitermination factor activity, RNA binding
AHiyo8_50730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AHiyo8_50740	COG0088	Forms part of the polypeptide exit tunnel
AHiyo8_50750	COG0089	rRNA binding
AHiyo8_50770	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AHiyo8_50780	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AHiyo8_50790	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AHiyo8_50800	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AHiyo8_50810	COG0255	Belongs to the universal ribosomal protein uL29 family
AHiyo8_50820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AHiyo8_50830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AHiyo8_50840	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AHiyo8_50850	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AHiyo8_50860	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AHiyo8_50870	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AHiyo8_50890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AHiyo8_50900	COG1841	ribosomal large subunit assembly
AHiyo8_50910	COG0200	Binds to the 23S rRNA
AHiyo8_50930	COG0201	protein transport
AHiyo8_50940	COG0563	adenylate kinase activity
AHiyo8_50990	COG1175	transmembrane transport
AHiyo8_51040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AHiyo8_51150	COG3191	aminopeptidase activity
AHiyo8_51160	COG3191	aminopeptidase activity
AHiyo8_51170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AHiyo8_51180	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AHiyo8_51190	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AHiyo8_51200	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AHiyo8_51210	COG0202	RNA polymerase activity
AHiyo8_51220	COG0202	RNA polymerase activity
AHiyo8_51230	COG0203	ribosomal protein L17
AHiyo8_51240	COG0101	tRNA pseudouridine synthase activity
AHiyo8_51290	COG2894	cell division
AHiyo8_51380	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AHiyo8_51390	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AHiyo8_51410	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AHiyo8_51430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AHiyo8_51440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AHiyo8_51450	COG1970	mechanosensitive ion channel activity
AHiyo8_51460	COG1876	peptidase activity
AHiyo8_51480	COG1072	(Pantothenic acid kinase))
AHiyo8_51490	COG1072	(Pantothenic acid kinase))
AHiyo8_51500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AHiyo8_51510	COG0736	holo-[acyl-carrier-protein] synthase activity
AHiyo8_51520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AHiyo8_51520	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AHiyo8_51640	COG0667	Aldo Keto reductase
AHiyo8_51680	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AHiyo8_51690	COG0438	transferase activity, transferring glycosyl groups
AHiyo8_51730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AHiyo8_51740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AHiyo8_51750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AHiyo8_51810	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AHiyo8_51820	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AHiyo8_51850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AHiyo8_51860	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AHiyo8_51900	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AHiyo8_51910	COG0459	protein refolding
AHiyo8_51920	COG0459	protein refolding
AHiyo8_51930	COG0459	protein refolding
AHiyo8_51940	COG2755	lipolytic protein G-D-S-L family
AHiyo8_51940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AHiyo8_51970	COG0516	GMP reductase activity
AHiyo8_51980	COG0516	GMP reductase activity
AHiyo8_51990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AHiyo8_52040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AHiyo8_52040	COG0519	Catalyzes the synthesis of GMP from XMP
AHiyo8_52050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AHiyo8_52050	COG0519	Catalyzes the synthesis of GMP from XMP
AHiyo8_52130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AHiyo8_52150	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AHiyo8_52270	COG3265	gluconokinase activity
AHiyo8_52320	COG0673	inositol 2-dehydrogenase activity
AHiyo8_52340	COG1609	Transcriptional regulator
AHiyo8_52350	COG1904	glucuronate isomerase
AHiyo8_52360	COG1904	glucuronate isomerase
AHiyo8_52380	COG0246	Mannitol dehydrogenase
AHiyo8_52420	COG4948	Mandelate Racemase Muconate Lactonizing
AHiyo8_52430	COG4948	Mandelate Racemase Muconate Lactonizing
AHiyo8_52440	COG3265	gluconokinase activity
AHiyo8_52520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AHiyo8_52580	COG0598	Magnesium transport protein CorA
AHiyo8_52650	COG0626	cystathionine gamma-synthase activity
AHiyo8_52660	COG0626	cystathionine gamma-synthase activity
AHiyo8_52670	COG2814	Major facilitator Superfamily
AHiyo8_52690	COG0583	DNA-binding transcription factor activity
AHiyo8_52770	COG1174	glycine betaine transport
AHiyo8_52830	COG2326	polyphosphate kinase activity
AHiyo8_52840	COG1722	exodeoxyribonuclease VII activity
AHiyo8_52850	COG1570	exodeoxyribonuclease VII activity
AHiyo8_52860	COG1570	exodeoxyribonuclease VII activity
AHiyo8_52890	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AHiyo8_52910	COG0012	GTP binding
AHiyo8_52990	COG4166	transmembrane transport
AHiyo8_53020	COG0601	transmembrane transport
AHiyo8_53080	COG4608	Belongs to the ABC transporter superfamily
AHiyo8_53100	COG4166	transmembrane transport
AHiyo8_53110	COG0601	transmembrane transport
AHiyo8_53130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AHiyo8_53140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AHiyo8_53150	COG0444	Belongs to the ABC transporter superfamily
AHiyo8_53270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AHiyo8_53290	COG3226	Transcriptional regulator
AHiyo8_53350	COG2171	N-acyltransferase activity
AHiyo8_53360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AHiyo8_53370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AHiyo8_53380	COG0765	amino acid transport
AHiyo8_53390	COG0765	amino acid transport
AHiyo8_53420	COG1126	abc transporter atp-binding protein
AHiyo8_53430	COG1611	Belongs to the LOG family
AHiyo8_53470	COG4122	O-methyltransferase activity
AHiyo8_53490	COG1595	DNA-templated transcription, initiation
AHiyo8_53500	COG1595	DNA-templated transcription, initiation
AHiyo8_53520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AHiyo8_53610	COG1136	(ABC) transporter
AHiyo8_53610	COG0577	efflux transmembrane transporter activity
AHiyo8_53640	COG0006	proline dipeptidase activity
AHiyo8_53650	COG0613	PHP domain protein
AHiyo8_53760	COG0352	thiamine-phosphate diphosphorylase activity
AHiyo8_53790	COG2022	thiamine diphosphate biosynthetic process
AHiyo8_53800	COG2154	pterin-4-alpha-carbinolamine dehydratase
AHiyo8_53880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AHiyo8_53890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AHiyo8_53900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AHiyo8_53910	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AHiyo8_53920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AHiyo8_53990	COG0181	hydroxymethylbilane synthase activity
AHiyo8_54010	COG0113	porphobilinogen synthase activity
AHiyo8_54030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AHiyo8_54040	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AHiyo8_54060	COG1472	Belongs to the glycosyl hydrolase 3 family
AHiyo8_54070	COG1472	Belongs to the glycosyl hydrolase 3 family
AHiyo8_54080	COG1126	abc transporter atp-binding protein
AHiyo8_54090	COG0765	amino acid transport
AHiyo8_54100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AHiyo8_54170	COG0210	DNA helicase
AHiyo8_54230	COG2816	NAD+ diphosphatase activity
AHiyo8_54270	COG3480	Lon protease (S16) C-terminal proteolytic domain
AHiyo8_54280	COG1615	UPF0182 protein
AHiyo8_54300	COG1615	UPF0182 protein
AHiyo8_54310	COG1615	UPF0182 protein
AHiyo8_54360	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AHiyo8_54390	COG1960	acyl-CoA dehydrogenase activity
AHiyo8_54400	COG1842	Phage shock protein A
AHiyo8_54430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AHiyo8_54440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AHiyo8_54450	COG2086	electron transfer activity
AHiyo8_54460	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AHiyo8_54490	COG3265	gluconokinase activity
AHiyo8_54530	COG0789	Transcriptional regulator
AHiyo8_54540	COG5343	regulation of RNA biosynthetic process
AHiyo8_54560	COG1595	DNA-templated transcription, initiation
AHiyo8_54570	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AHiyo8_54590	COG0484	heat shock protein binding
AHiyo8_54690	COG0482	sulfurtransferase activity
AHiyo8_54700	COG0482	sulfurtransferase activity
AHiyo8_54720	COG0601	transmembrane transport
AHiyo8_54730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AHiyo8_54830	COG0714	Associated with various cellular activities
AHiyo8_54910	COG5002	protein histidine kinase activity
AHiyo8_54910	COG5000	phosphorelay sensor kinase activity
AHiyo8_54930	COG5401	PFAM Sporulation and spore germination
AHiyo8_54950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AHiyo8_54970	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AHiyo8_55000	COG0653	protein targeting
AHiyo8_55010	COG0653	protein targeting
AHiyo8_55130	COG2902	Dehydrogenase
AHiyo8_55260	COG1216	Glycosyl transferase, family 2
AHiyo8_55320	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AHiyo8_55350	COG1216	Glycosyl transferase, family 2
AHiyo8_55350	COG0463	Glycosyl transferase, family 2
AHiyo8_55430	COG1215	transferase activity, transferring glycosyl groups
AHiyo8_55440	COG1088	dTDP-glucose 4,6-dehydratase activity
AHiyo8_55480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AHiyo8_55680	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AHiyo8_55690	COG2884	Cell division ATP-binding protein ftsE
AHiyo8_55700	COG2177	Part of the ABC transporter FtsEX involved in
AHiyo8_55720	COG0739	heme binding
AHiyo8_55730	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AHiyo8_55770	COG0701	Predicted permease
AHiyo8_55830	COG2801	Transposase and inactivated derivatives
AHiyo8_55890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AHiyo8_55910	COG0483	inositol monophosphate 1-phosphatase activity
AHiyo8_55930	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AHiyo8_55950	COG1595	DNA-templated transcription, initiation
AHiyo8_56000	COG0567	Dehydrogenase, E1 component
AHiyo8_56010	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHiyo8_56010	COG0567	Dehydrogenase, E1 component
AHiyo8_56100	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AHiyo8_56170	COG1064	alcohol dehydrogenase
AHiyo8_56180	COG1064	alcohol dehydrogenase
AHiyo8_56200	COG1643	Atp-dependent helicase
AHiyo8_56220	COG1643	Atp-dependent helicase
AHiyo8_56230	COG1643	Atp-dependent helicase
AHiyo8_56240	COG1643	Atp-dependent helicase
AHiyo8_56250	COG1643	Atp-dependent helicase
AHiyo8_56380	COG0018	arginyl-trna synthetase
AHiyo8_56390	COG0018	arginyl-trna synthetase
AHiyo8_56400	COG0019	diaminopimelate decarboxylase activity
AHiyo8_56410	COG0460	homoserine dehydrogenase
AHiyo8_56420	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AHiyo8_56430	COG0083	homoserine kinase activity
AHiyo8_56460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AHiyo8_56470	COG2890	protein-(glutamine-N5) methyltransferase activity
AHiyo8_56530	COG0356	it plays a direct role in the translocation of protons across the membrane
AHiyo8_56540	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AHiyo8_56550	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AHiyo8_56560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AHiyo8_56570	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AHiyo8_56580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AHiyo8_56590	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AHiyo8_56600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AHiyo8_56610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AHiyo8_56640	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AHiyo8_56690	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AHiyo8_56730	COG1228	amidohydrolase
AHiyo8_56740	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AHiyo8_56860	COG1902	pentaerythritol trinitrate reductase activity
AHiyo8_56890	COG0363	glucosamine-6-phosphate deaminase activity
AHiyo8_56910	COG1061	Type III restriction enzyme res subunit
AHiyo8_56920	COG1335	isochorismatase
AHiyo8_56960	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AHiyo8_57030	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AHiyo8_57040	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AHiyo8_57050	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AHiyo8_57060	COG0586	Pfam SNARE associated Golgi protein
AHiyo8_57160	COG2149	membrane
AHiyo8_57180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AHiyo8_57210	COG0419	ATPase involved in DNA repair
AHiyo8_57220	COG0419	ATPase involved in DNA repair
AHiyo8_57240	COG0419	ATPase involved in DNA repair
AHiyo8_57350	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHiyo8_57360	COG0022	dehydrogenase e1 component
AHiyo8_57380	COG1113	amino acid transport
AHiyo8_57390	COG1113	amino acid transport
AHiyo8_57400	COG1113	amino acid transport
AHiyo8_57430	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AHiyo8_57440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AHiyo8_57460	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AHiyo8_57490	COG1104	cysteine desulfurase activity
AHiyo8_57530	COG0179	Fumarylacetoacetate (FAA) hydrolase
AHiyo8_57560	COG1305	Transglutaminase-like
AHiyo8_57600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AHiyo8_57610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AHiyo8_57620	COG0579	oxidoreductase
AHiyo8_57630	COG0747	negative chemotaxis
AHiyo8_57690	COG0129	dihydroxy-acid dehydratase activity
AHiyo8_57700	COG0129	dihydroxy-acid dehydratase activity
AHiyo8_57710	COG0129	dihydroxy-acid dehydratase activity
AHiyo8_57720	COG0028	Belongs to the TPP enzyme family
AHiyo8_57740	COG0440	acetolactate synthase activity
AHiyo8_57760	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AHiyo8_57780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AHiyo8_57830	COG1136	(ABC) transporter
AHiyo8_57840	COG1136	(ABC) transporter
AHiyo8_57900	COG0473	3-isopropylmalate dehydrogenase activity
AHiyo8_57910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AHiyo8_57920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AHiyo8_57950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AHiyo8_57960	COG0179	Fumarylacetoacetate (FAA) hydrolase
AHiyo8_57970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AHiyo8_57980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AHiyo8_58050	COG1414	Transcriptional regulator
AHiyo8_58060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AHiyo8_58070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AHiyo8_58080	COG0066	3-isopropylmalate dehydratase activity
AHiyo8_58090	COG0066	3-isopropylmalate dehydratase activity
AHiyo8_58110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AHiyo8_58140	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AHiyo8_58150	COG1181	Belongs to the D-alanine--D-alanine ligase family
AHiyo8_58160	COG1181	Belongs to the D-alanine--D-alanine ligase family
AHiyo8_58210	COG1461	Dihydroxyacetone kinase
AHiyo8_58260	COG0742	ribosomal rna small subunit methyltransferase
AHiyo8_58280	COG0436	Aminotransferase
AHiyo8_58300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AHiyo8_58320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AHiyo8_58330	COG0571	ribonuclease III activity
AHiyo8_58340	COG0571	ribonuclease III activity
AHiyo8_58350	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AHiyo8_58380	COG1196	nuclear chromosome segregation
AHiyo8_58390	COG1196	nuclear chromosome segregation
AHiyo8_58400	COG1196	nuclear chromosome segregation
AHiyo8_58420	COG2814	Major facilitator Superfamily
AHiyo8_58500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AHiyo8_58520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AHiyo8_58560	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AHiyo8_58610	COG2514	catechol 2,3-dioxygenase activity
AHiyo8_58630	COG0228	four-way junction DNA binding
AHiyo8_58640	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AHiyo8_58650	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AHiyo8_58660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AHiyo8_58670	COG0336	Belongs to the RNA methyltransferase TrmD family
AHiyo8_58680	COG0335	large ribosomal subunit rRNA binding
AHiyo8_58690	COG0681	Belongs to the peptidase S26 family
AHiyo8_58710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AHiyo8_58730	COG0792	nuclease activity
AHiyo8_58910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AHiyo8_59150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AHiyo8_59180	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AHiyo8_59600	COG4974	Belongs to the 'phage' integrase family
AHiyo8_59620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AHiyo8_59640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AHiyo8_59650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AHiyo8_59680	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AHiyo8_59690	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AHiyo8_59700	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AHiyo8_59780	COG0477	Major facilitator Superfamily
AHiyo8_59790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AHiyo8_59820	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_59830	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_59840	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_59880	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AHiyo8_59890	COG0300	oxidoreductase activity
AHiyo8_59940	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AHiyo8_59950	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AHiyo8_59960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AHiyo8_60040	COG0242	peptide deformylase activity
AHiyo8_60060	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AHiyo8_60160	COG0024	Methionine aminopeptidase
AHiyo8_60230	COG1946	Acyl-CoA thioesterase
AHiyo8_60270	COG0668	transmembrane transport
AHiyo8_60350	COG0544	peptidyl-prolyl cis-trans isomerase activity
AHiyo8_60360	COG0544	peptidyl-prolyl cis-trans isomerase activity
AHiyo8_60370	COG0740	serine-type endopeptidase activity
AHiyo8_60380	COG0740	serine-type endopeptidase activity
AHiyo8_60390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AHiyo8_60400	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AHiyo8_60410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AHiyo8_60420	COG0525	valine-tRNA ligase activity
AHiyo8_60430	COG3189	MarR family transcriptional regulator
AHiyo8_60480	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AHiyo8_60490	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AHiyo8_60500	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AHiyo8_60510	COG0285	dihydrofolate synthase activity
AHiyo8_60530	COG0105	UTP biosynthetic process
AHiyo8_60570	COG1530	ribonuclease E activity
AHiyo8_60580	COG0351	phosphomethylpyrimidine kinase
AHiyo8_60580	COG0352	thiamine-phosphate diphosphorylase activity
AHiyo8_60580	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AHiyo8_60590	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AHiyo8_60590	COG0352	thiamine-phosphate diphosphorylase activity
AHiyo8_60590	COG0351	phosphomethylpyrimidine kinase
AHiyo8_60600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AHiyo8_60610	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AHiyo8_60620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AHiyo8_60630	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AHiyo8_60640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AHiyo8_60670	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AHiyo8_60770	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AHiyo8_60780	COG0587	DNA-directed DNA polymerase activity
AHiyo8_60790	COG0587	DNA-directed DNA polymerase activity
AHiyo8_60800	COG0587	DNA-directed DNA polymerase activity
AHiyo8_60810	COG0587	DNA-directed DNA polymerase activity
AHiyo8_60820	COG0587	DNA-directed DNA polymerase activity
AHiyo8_60830	COG0587	DNA-directed DNA polymerase activity
AHiyo8_60880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AHiyo8_60960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AHiyo8_60980	COG4172	Belongs to the ABC transporter superfamily
AHiyo8_60990	COG0444	Belongs to the ABC transporter superfamily
AHiyo8_61030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AHiyo8_61040	COG0154	amidase activity
AHiyo8_61060	COG0154	amidase activity
AHiyo8_61070	COG2957	Belongs to the agmatine deiminase family
AHiyo8_61100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AHiyo8_61140	COG0477	Major facilitator Superfamily
AHiyo8_61160	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_61180	COG1309	transcriptional regulator
AHiyo8_61240	COG2813	Specifically methylates the guanine in position
AHiyo8_61270	COG1940	carbohydrate kinase activity
AHiyo8_61270	COG1846	Transcriptional regulator
AHiyo8_61330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AHiyo8_61350	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AHiyo8_61360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AHiyo8_61390	COG0583	DNA-binding transcription factor activity
AHiyo8_61410	COG1780	Probably involved in ribonucleotide reductase function
AHiyo8_61420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AHiyo8_61430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AHiyo8_61570	COG2205	protein histidine kinase activity
AHiyo8_61570	COG2198	Histidine kinase
AHiyo8_61570	COG0784	Response regulator, receiver
AHiyo8_61600	COG1234	tRNA 3'-trailer cleavage
AHiyo8_61610	COG1234	tRNA 3'-trailer cleavage
AHiyo8_61620	COG0412	Dienelactone hydrolase
AHiyo8_61640	COG4804	nuclease activity
AHiyo8_61870	COG0494	nUDIX hydrolase
AHiyo8_61880	COG1349	DNA-binding transcription factor activity
AHiyo8_61900	COG1064	alcohol dehydrogenase
AHiyo8_61980	COG1643	Atp-dependent helicase
AHiyo8_61990	COG1643	Atp-dependent helicase
AHiyo8_62100	COG0009	L-threonylcarbamoyladenylate synthase
AHiyo8_62190	COG3844	kynureninase activity
AHiyo8_62210	COG3483	tryptophan 2,3-dioxygenase activity
AHiyo8_62250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AHiyo8_62260	COG2050	protein possibly involved in aromatic compounds catabolism
AHiyo8_62310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AHiyo8_62310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AHiyo8_62320	COG4552	Acetyltransferase involved in intracellular survival and related
AHiyo8_62330	COG4552	Acetyltransferase involved in intracellular survival and related
AHiyo8_62350	COG0539	negative regulation of cytoplasmic translation
AHiyo8_62360	COG0539	negative regulation of cytoplasmic translation
AHiyo8_62370	COG1739	Uncharacterized protein family UPF0029
AHiyo8_62380	COG0237	dephospho-CoA kinase activity
AHiyo8_62390	COG0237	dephospho-CoA kinase activity
AHiyo8_62390	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AHiyo8_62400	COG0556	nucleotide-excision repair
AHiyo8_62430	COG0556	nucleotide-excision repair
AHiyo8_62450	COG0861	Integral membrane protein TerC family
AHiyo8_62570	COG4106	trans-aconitate 2-methyltransferase activity
AHiyo8_62630	COG1132	(ABC) transporter
AHiyo8_62660	COG0546	phosphoglycolate phosphatase activity
AHiyo8_62690	COG0322	excinuclease ABC activity
AHiyo8_62700	COG0322	excinuclease ABC activity
AHiyo8_62710	COG0322	excinuclease ABC activity
AHiyo8_62720	COG0322	excinuclease ABC activity
AHiyo8_62730	COG1660	Displays ATPase and GTPase activities
AHiyo8_62740	COG1660	Displays ATPase and GTPase activities
AHiyo8_62750	COG1660	Displays ATPase and GTPase activities
AHiyo8_62760	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AHiyo8_62780	COG1481	regulation of sporulation
AHiyo8_62800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AHiyo8_62810	COG0126	phosphoglycerate kinase activity
AHiyo8_62820	COG0149	triose-phosphate isomerase activity
AHiyo8_62830	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AHiyo8_62850	COG0363	glucosamine-6-phosphate deaminase activity
AHiyo8_62900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AHiyo8_62920	COG0109	protoheme IX farnesyltransferase activity
AHiyo8_62930	COG0109	protoheme IX farnesyltransferase activity
AHiyo8_62940	COG1612	heme a metabolic process
AHiyo8_63010	COG0719	Fe-S assembly protein
AHiyo8_63040	COG0396	ATPase activity
AHiyo8_63050	COG0396	ATPase activity
AHiyo8_63060	COG2151	metal-sulfur cluster biosynthetic enzyme
AHiyo8_63110	COG0183	Belongs to the thiolase family
AHiyo8_63130	COG1122	ATPase activity
AHiyo8_63140	COG1268	BioY protein
AHiyo8_63170	COG0488	(ABC) transporter
AHiyo8_63250	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_63260	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_63270	COG3830	Belongs to the UPF0237 family
AHiyo8_63270	COG0560	Phosphoserine phosphatase
AHiyo8_63280	COG3830	Belongs to the UPF0237 family
AHiyo8_63280	COG0560	Phosphoserine phosphatase
AHiyo8_63310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AHiyo8_63350	COG1595	DNA-templated transcription, initiation
AHiyo8_63380	COG0254	rRNA binding
AHiyo8_63430	COG2855	membrane
AHiyo8_63480	COG2308	Evidence 4 Homologs of previously reported genes of
AHiyo8_63570	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AHiyo8_63580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AHiyo8_63590	COG0297	glycogen (starch) synthase activity
AHiyo8_63670	COG0183	Belongs to the thiolase family
AHiyo8_63720	COG1028	Short-chain dehydrogenase reductase Sdr
AHiyo8_63740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AHiyo8_63810	COG0656	L-ascorbic acid biosynthetic process
AHiyo8_63820	COG1968	undecaprenyl-diphosphatase activity
AHiyo8_63840	COG0215	cysteine-tRNA ligase activity
AHiyo8_63860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AHiyo8_63870	COG0517	IMP dehydrogenase activity
AHiyo8_63870	COG1994	Peptidase M50
AHiyo8_63890	COG1222	aaa ATPase
AHiyo8_63900	COG1222	aaa ATPase
AHiyo8_63910	COG4122	O-methyltransferase activity
AHiyo8_63920	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AHiyo8_63930	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AHiyo8_63940	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AHiyo8_63950	COG0545	Peptidyl-prolyl cis-trans isomerase
AHiyo8_63990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AHiyo8_64000	COG0805	protein transport
AHiyo8_64050	COG4581	dead DEAH box helicase
AHiyo8_64070	COG1216	Glycosyl transferase, family 2
AHiyo8_64080	COG3422	double-strand break repair
AHiyo8_64100	COG0515	serine threonine protein kinase
AHiyo8_64130	COG0800	Aldolase
AHiyo8_64170	COG0477	Major facilitator Superfamily
AHiyo8_64180	COG0477	Major facilitator Superfamily
AHiyo8_64190	COG1063	alcohol dehydrogenase
AHiyo8_64200	COG0246	Mannitol dehydrogenase
AHiyo8_64220	COG4948	Mandelate Racemase Muconate Lactonizing
AHiyo8_64230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AHiyo8_64280	COG0405	Gamma-glutamyltransferase
AHiyo8_64300	COG0405	Gamma-glutamyltransferase
AHiyo8_64350	COG3958	Transketolase
AHiyo8_64360	COG3959	Transketolase, thiamine diphosphate binding domain
AHiyo8_64480	COG0076	glutamate decarboxylase activity
AHiyo8_64530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AHiyo8_64540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AHiyo8_64570	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AHiyo8_64590	COG0339	signal peptide processing
AHiyo8_64650	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AHiyo8_64660	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AHiyo8_64670	COG0217	transcriptional regulatory protein
AHiyo8_64680	COG0217	transcriptional regulatory protein
AHiyo8_64690	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AHiyo8_64700	COG0632	four-way junction helicase activity
AHiyo8_64710	COG2255	four-way junction helicase activity
AHiyo8_64730	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AHiyo8_64740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AHiyo8_64750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AHiyo8_64760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AHiyo8_64770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AHiyo8_64800	COG1196	nuclear chromosome segregation
AHiyo8_64840	COG0124	histidyl-tRNA synthetase
AHiyo8_64850	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AHiyo8_64860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AHiyo8_64930	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AHiyo8_64960	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AHiyo8_64970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AHiyo8_64980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AHiyo8_64990	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AHiyo8_65000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AHiyo8_65010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AHiyo8_65050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AHiyo8_65060	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AHiyo8_65070	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AHiyo8_65080	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AHiyo8_65100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AHiyo8_65110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AHiyo8_65120	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AHiyo8_65140	COG0540	Belongs to the ATCase OTCase family
AHiyo8_65150	COG0540	Belongs to the ATCase OTCase family
AHiyo8_65160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AHiyo8_65170	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AHiyo8_65180	COG0505	Belongs to the CarA family
AHiyo8_65190	COG0505	Belongs to the CarA family
AHiyo8_65200	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AHiyo8_65210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AHiyo8_65220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AHiyo8_65230	COG0284	orotidine-5'-phosphate decarboxylase activity
AHiyo8_65240	COG0194	GDP metabolic process
AHiyo8_65250	COG0194	GDP metabolic process
AHiyo8_65260	COG1758	RNA polymerase activity
AHiyo8_65290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AHiyo8_65300	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AHiyo8_65390	COG0656	L-ascorbic acid biosynthetic process
AHiyo8_65400	COG2390	Transcriptional regulator
AHiyo8_65410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AHiyo8_65420	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AHiyo8_65430	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AHiyo8_65440	COG0495	leucyl-tRNA aminoacylation
AHiyo8_65460	COG0495	leucyl-tRNA aminoacylation
AHiyo8_65470	COG0495	leucyl-tRNA aminoacylation
AHiyo8_65480	COG1307	EDD domain protein, DegV family
AHiyo8_65700	COG1937	Protein conserved in bacteria
AHiyo8_65750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AHiyo8_pI65930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AHiyo8_pI65990	COG0477	Major facilitator Superfamily
AHiyo8_pI66170	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AHiyo8_pI66180	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AHiyo8_pI66220	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AHiyo8_pI66230	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AHiyo8_pI66240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AHiyo8_pI66280	COG1129	ABC transporter
AHiyo8_pI66300	COG1172	Belongs to the binding-protein-dependent transport system permease family
AHiyo8_pI66360	COG1063	alcohol dehydrogenase
AHiyo8_pI66400	COG0673	inositol 2-dehydrogenase activity
AHiyo8_pI66410	COG0673	inositol 2-dehydrogenase activity
AHiyo8_pI66450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AHiyo8_pI66460	COG1011	Hydrolase
AHiyo8_pI66500	COG1192	Involved in chromosome partitioning
AHiyo8_pI66990	COG1136	(ABC) transporter
AHiyo8_pI67000	COG1136	(ABC) transporter
AHiyo8_pI67000	COG0577	efflux transmembrane transporter activity
AHiyo8_pI67010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AHiyo8_pI67090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AHiyo8_pI67290	COG3706	GGDEF domain
AHiyo8_pI67310	COG2826	transposase and inactivated derivatives, IS30 family
AHiyo8_pI67320	COG4565	transcriptional regulatory protein
AHiyo8_pI67330	COG3290	protein histidine kinase activity
AHiyo8_pI67350	COG3290	protein histidine kinase activity
AHiyo8_pI67360	COG3290	protein histidine kinase activity
AHiyo8_pI67370	COG1116	anion transmembrane transporter activity
AHiyo8_pI67380	COG1116	anion transmembrane transporter activity
AHiyo8_pI67470	COG1846	Transcriptional regulator
AHiyo8_pI67490	COG2814	Major facilitator Superfamily
AHiyo8_pI67510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AHiyo8_pI67540	COG3511	phospholipase C
AHiyo8_pI67600	COG2963	transposase activity
AHiyo8_pI67620	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AHiyo8_pI67720	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AHiyo8_pI67760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AHiyo8_pI67930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AHiyo8_pI67940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AHiyo8_pI67960	COG0473	3-isopropylmalate dehydrogenase activity
AHiyo8_pI67970	COG0473	3-isopropylmalate dehydrogenase activity
AHiyo8_pI67980	COG1027	Aspartate ammonia-lyase
AHiyo8_pI67990	COG1027	Aspartate ammonia-lyase
AHiyo8_pI68120	COG0601	transmembrane transport
AHiyo8_pI68150	COG1914	H( )-stimulated, divalent metal cation uptake system
AHiyo8_pI68170	COG2186	Transcriptional regulator
AHiyo8_pI68260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AHiyo8_pI68420	COG1937	Protein conserved in bacteria
AHiyo8_pI68430	COG0701	Predicted permease
AHiyo8_pI68440	COG0701	Predicted permease
AHiyo8_pI68500	COG1802	Transcriptional regulator
AHiyo8_pI68580	COG2801	Transposase and inactivated derivatives
AHiyo8_pI68580	COG3415	Transposase
AHiyo8_pI68610	COG1929	Belongs to the glycerate kinase type-1 family
AHiyo8_pI68620	COG1929	Belongs to the glycerate kinase type-1 family
AHiyo8_pI68690	COG4608	Belongs to the ABC transporter superfamily
AHiyo8_pI68710	COG0444	Belongs to the ABC transporter superfamily
AHiyo8_pI68720	COG0601	transmembrane transport
AHiyo8_pI68740	COG1454	alcohol dehydrogenase
AHiyo8_pI68840	COG2175	clavaminate synthase activity
AHiyo8_pI68880	COG2814	Major facilitator Superfamily
AHiyo8_pI69030	COG3547	Transposase (IS116 IS110 IS902 family)
AHiyo8_pI69320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AHiyo8_pI69870	COG3547	Transposase (IS116 IS110 IS902 family)
AHiyo8_pI69930	COG2826	transposase and inactivated derivatives, IS30 family
AHiyo8_pI70050	COG1937	Protein conserved in bacteria
AHiyo8_pI70090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AHiyo8_pI70110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid