locus-tag	class	description
UM93_00020	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
UM93_00025	COG4585	Histidine kinase
UM93_00030	COG2197	response regulator
UM93_00035	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UM93_00085	COG1309	transcriptional regulator
UM93_00090	COG2409	Drug exporters of the RND superfamily
UM93_00120	COG1131	(ABC) transporter
UM93_00150	COG1181	Belongs to the D-alanine--D-alanine ligase family
UM93_00165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UM93_00185	COG0372	Belongs to the citrate synthase family
UM93_00205	COG2197	response regulator
UM93_00235	COG0180	Tryptophanyl-tRNA synthetase
UM93_00260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
UM93_00275	COG2009	succinate dehydrogenase
UM93_00285	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
UM93_00285	COG1473	amidohydrolase
UM93_00290	COG1846	Transcriptional regulator
UM93_00295	COG1764	response to oxidative stress
UM93_00300	COG2130	NADP-dependent
UM93_00305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UM93_00355	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
UM93_00375	COG0148	phosphopyruvate hydratase activity
UM93_00415	COG0789	Transcriptional regulator
UM93_00420	COG1028	Short-chain dehydrogenase reductase Sdr
UM93_00430	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
UM93_00445	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UM93_00450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
UM93_00460	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UM93_00475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
UM93_00480	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
UM93_00510	COG0114	fumarate hydratase activity
UM93_00525	COG1494	fructose-1,6-bisphosphatase
UM93_00545	COG1482	cell wall glycoprotein biosynthetic process
UM93_00550	COG1316	TRANSCRIPTIONal
UM93_00555	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
UM93_00605	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
UM93_00660	COG0714	Associated with various cellular activities
UM93_00665	COG0084	hydrolase, TatD family'
UM93_00670	COG3583	domain protein
UM93_00675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
UM93_00680	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
UM93_00685	COG0488	(ABC) transporter
UM93_00695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
UM93_00700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
UM93_00705	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
UM93_00710	COG0193	aminoacyl-tRNA hydrolase activity
UM93_00725	COG0822	iron-sulfur transferase activity
UM93_00740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UM93_00775	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
UM93_00815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
UM93_00820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UM93_00835	COG0477	Major facilitator Superfamily
UM93_00840	COG4770	biotin carboxylase activity
UM93_00860	COG0424	maF-like protein
UM93_00880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UM93_00885	COG1028	Short-chain dehydrogenase reductase Sdr
UM93_00890	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
UM93_00890	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
UM93_00910	COG0714	Associated with various cellular activities
UM93_00960	COG1674	ftsk spoiiie
UM93_00980	COG0483	inositol monophosphate 1-phosphatase activity
UM93_01010	COG0367	asparagine synthase
UM93_01020	COG0423	glycine-tRNA ligase activity
UM93_01035	COG0583	DNA-binding transcription factor activity
UM93_01100	COG1131	(ABC) transporter
UM93_01115	COG2197	response regulator
UM93_01135	COG0358	DNA primase activity
UM93_01145	COG0596	Alpha beta hydrolase
UM93_01150	COG3591	Belongs to the peptidase S1B family
UM93_01170	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
UM93_01190	COG0438	transferase activity, transferring glycosyl groups
UM93_01255	COG0052	Belongs to the universal ribosomal protein uS2 family
UM93_01260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
UM93_01265	COG0384	phenazine biosynthesis protein PhzF
UM93_01290	COG0528	UMP kinase activity
UM93_01295	COG0233	cytoplasmic translational termination
UM93_01310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UM93_01320	COG3279	Response regulator of the LytR AlgR family
UM93_01325	COG3275	phosphorelay sensor kinase activity
UM93_01335	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UM93_01360	COG0022	dehydrogenase e1 component
UM93_01365	COG0508	dehydrogenase complex catalyzes the overall conversion of
UM93_01370	COG1309	transcriptional regulator
UM93_01375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UM93_01385	COG1960	acyl-CoA dehydrogenase activity
UM93_01410	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
UM93_01415	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
UM93_01420	COG0750	zinc metalloprotease
UM93_01440	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
UM93_01450	COG0596	Alpha beta hydrolase
UM93_01485	COG0442	prolyl-tRNA aminoacylation
UM93_01520	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
UM93_01525	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
UM93_01535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
UM93_01555	COG0039	L-malate dehydrogenase activity
UM93_01570	COG0604	alcohol dehydrogenase
UM93_01575	COG4977	sequence-specific DNA binding
UM93_01580	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
UM93_01585	COG1185	polyribonucleotide nucleotidyltransferase activity
UM93_01590	COG0612	Peptidase, M16
UM93_01660	COG5002	protein histidine kinase activity
UM93_01665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
UM93_01675	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
UM93_01690	COG0521	Mo-molybdopterin cofactor biosynthetic process
UM93_01705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
UM93_01715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UM93_01720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UM93_01725	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
UM93_01730	COG0596	Alpha beta hydrolase
UM93_01750	COG0395	ABC-type sugar transport system, permease component
UM93_01760	COG1609	Transcriptional regulator
UM93_01775	COG1175	transmembrane transport
UM93_01780	COG0395	ABC-type sugar transport system, permease component
UM93_01795	COG1674	ftsk spoiiie
UM93_01805	COG1546	Belongs to the CinA family
UM93_01805	COG1058	Belongs to the CinA family
UM93_01825	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
UM93_01830	COG2137	regulation of response to DNA damage stimulus
UM93_01840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UM93_01845	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
UM93_01850	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
UM93_01860	COG2813	Specifically methylates the guanine in position
UM93_01875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
UM93_01885	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
UM93_01895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
UM93_01900	COG0131	Imidazoleglycerol-phosphate dehydratase
UM93_01910	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
UM93_01940	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
UM93_01945	COG0291	Belongs to the bacterial ribosomal protein bL35 family
UM93_01950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
UM93_01955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UM93_01970	COG2814	Major facilitator Superfamily
UM93_01975	COG0494	nUDIX hydrolase
UM93_01995	COG0318	PFAM AMP-dependent synthetase and ligase
UM93_02010	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
UM93_02015	COG0072	phenylalanine-tRNA ligase activity
UM93_02015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UM93_02020	COG2326	polyphosphate kinase activity
UM93_02050	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
UM93_02055	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
UM93_02060	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
UM93_02065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
UM93_02070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
UM93_02075	COG1438	arginine binding
UM93_02080	COG0137	argininosuccinate synthase activity
UM93_02085	COG0165	Argininosuccinate lyase
UM93_02135	COG2169	Transcriptional regulator
UM93_02135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
UM93_02160	COG2094	Belongs to the DNA glycosylase MPG family
UM93_02180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UM93_02190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
UM93_02220	COG0745	RESPONSE REGULATOR receiver
UM93_02225	COG2205	protein histidine kinase activity
UM93_02235	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
UM93_02255	COG0647	UMP catabolic process
UM93_02275	COG0497	DNA recombination
UM93_02285	COG0504	CTP synthase activity
UM93_02310	COG2197	response regulator
UM93_02330	COG1595	DNA-templated transcription, initiation
UM93_02345	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
UM93_02350	COG2079	MmgE PrpD family protein
UM93_02365	COG3654	unkown
UM93_02370	COG1834	amidinotransferase
UM93_02375	COG1120	ATPase activity
UM93_02400	COG2382	esterase
UM93_02405	COG3486	L-lysine 6-monooxygenase (NADPH) activity
UM93_02415	COG4565	transcriptional regulatory protein
UM93_02425	COG1301	dicarboxylic acid transport
UM93_02450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
UM93_02465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
UM93_02475	COG1160	GTP binding
UM93_02500	COG4221	oxidoreductase activity
UM93_02525	COG0395	ABC-type sugar transport system, permease component
UM93_02530	COG1175	transmembrane transport
UM93_02540	COG1609	Transcriptional regulator
UM93_02545	COG0747	negative chemotaxis
UM93_02550	COG0601	transmembrane transport
UM93_02570	COG4941	Belongs to the sigma-70 factor family
UM93_02575	COG3795	YCII-related domain
UM93_02600	COG0346	lactoylglutathione lyase activity
UM93_02605	COG0789	Transcriptional regulator
UM93_02655	COG1846	Transcriptional regulator
UM93_02680	COG2267	carboxylic ester hydrolase activity
UM93_02690	COG1609	Transcriptional regulator
UM93_02715	COG0509	glycine decarboxylation via glycine cleavage system
UM93_02745	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
UM93_02760	COG1940	carbohydrate kinase activity
UM93_02780	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
UM93_02785	COG0515	serine threonine protein kinase
UM93_02785	COG2815	serine threonine protein kinase
UM93_02790	COG0791	NLP P60 protein
UM93_02790	COG1388	LysM domain
UM93_02800	COG0142	geranyltranstransferase activity
UM93_02810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UM93_02820	COG2001	Belongs to the MraZ family
UM93_02825	COG0275	rRNA processing
UM93_02835	COG0768	penicillin binding
UM93_02840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
UM93_02845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UM93_02850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UM93_02855	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
UM93_02865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
UM93_02880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
UM93_02895	COG1799	cell septum assembly
UM93_02905	COG3599	regulation of cell shape
UM93_02910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
UM93_02925	COG0587	DNA-directed DNA polymerase activity
UM93_02935	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
UM93_02940	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
UM93_02945	COG1028	Short-chain dehydrogenase reductase Sdr
UM93_02965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
UM93_02970	COG0174	glutamine synthetase
UM93_02975	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
UM93_03000	COG2011	ABC-type metal ion transport system permease component
UM93_03005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UM93_03010	COG1464	Belongs to the NlpA lipoprotein family
UM93_03035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
UM93_03040	COG0321	lipoyl(octanoyl) transferase activity
UM93_03050	COG1090	epimerase
UM93_03055	COG4946	Tricorn protease homolog
UM93_03055	COG0793	Belongs to the peptidase S41A family
UM93_03060	COG1764	response to oxidative stress
UM93_03080	COG0508	dehydrogenase complex catalyzes the overall conversion of
UM93_03085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UM93_03090	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
UM93_03105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UM93_03115	COG0187	DNA topoisomerase II activity
UM93_03135	COG1271	oxidase subunit
UM93_03140	COG1294	oxidase, subunit
UM93_03160	COG2076	Multidrug Resistance protein
UM93_03165	COG2720	vancomycin resistance protein
UM93_03175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UM93_03175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UM93_03235	COG0569	domain protein
UM93_03240	COG0531	amino acid
UM93_03245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UM93_03320	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
UM93_03325	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
UM93_03335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
UM93_03350	COG0667	Aldo Keto reductase
UM93_03355	COG3290	protein histidine kinase activity
UM93_03360	COG4565	transcriptional regulatory protein
UM93_03365	COG1250	3-hydroxyacyl-CoA dehydrogenase
UM93_03365	COG1024	Enoyl-CoA hydratase
UM93_03370	COG0183	Belongs to the thiolase family
UM93_03375	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
UM93_03400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UM93_03415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
UM93_03435	COG3135	benzoate transporter
UM93_03445	COG2076	Multidrug Resistance protein
UM93_03480	COG0242	peptide deformylase activity
UM93_03485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
UM93_03495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
UM93_03515	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UM93_03515	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UM93_03520	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UM93_03520	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UM93_03525	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
UM93_03530	COG0140	phosphoribosyl-ATP diphosphatase activity
UM93_03535	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
UM93_03540	COG0107	imidazoleglycerol-phosphate synthase activity
UM93_03550	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
UM93_03570	COG0134	indole-3-glycerol-phosphate synthase activity
UM93_03580	COG0159	tryptophan synthase activity
UM93_03590	COG0070	glutamate synthase
UM93_03590	COG0069	glutamate synthase activity
UM93_03590	COG0067	glutamate synthase
UM93_03635	COG0438	transferase activity, transferring glycosyl groups
UM93_03635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
UM93_03640	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
UM93_03655	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
UM93_03665	COG2050	protein possibly involved in aromatic compounds catabolism
UM93_03695	COG4552	Acetyltransferase involved in intracellular survival and related
UM93_03700	COG4552	Acetyltransferase involved in intracellular survival and related
UM93_03705	COG0539	negative regulation of cytoplasmic translation
UM93_03715	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
UM93_03715	COG0237	dephospho-CoA kinase activity
UM93_03730	COG0556	nucleotide-excision repair
UM93_03735	COG0861	Integral membrane protein TerC family
UM93_03770	COG0640	Transcriptional regulator
UM93_03780	COG4106	trans-aconitate 2-methyltransferase activity
UM93_03815	COG0322	excinuclease ABC activity
UM93_03820	COG1660	Displays ATPase and GTPase activities
UM93_03825	COG0391	Required for morphogenesis under gluconeogenic growth conditions
UM93_03830	COG1481	regulation of sporulation
UM93_03835	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
UM93_03840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UM93_03845	COG0126	phosphoglycerate kinase activity
UM93_03865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UM93_03885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UM93_03905	COG0149	triose-phosphate isomerase activity
UM93_03910	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
UM93_03920	COG0363	glucosamine-6-phosphate deaminase activity
UM93_03940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
UM93_03950	COG0109	protoheme IX farnesyltransferase activity
UM93_03970	COG0768	penicillin binding
UM93_03985	COG0719	Fe-S assembly protein
UM93_03995	COG0396	ATPase activity
UM93_04000	COG2151	metal-sulfur cluster biosynthetic enzyme
UM93_04010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
UM93_04025	COG1268	BioY protein
UM93_04030	COG0488	(ABC) transporter
UM93_04055	COG1028	Short-chain dehydrogenase reductase Sdr
UM93_04060	COG1028	Short-chain dehydrogenase reductase Sdr
UM93_04070	COG1119	ATPase activity
UM93_04090	COG0254	rRNA binding
UM93_04120	COG2855	membrane
UM93_04135	COG1305	Transglutaminase-like
UM93_04220	COG0297	glycogen (starch) synthase activity
UM93_04230	COG1309	transcriptional regulator
UM93_04235	COG0183	Belongs to the thiolase family
UM93_04240	COG1028	Short-chain dehydrogenase reductase Sdr
UM93_04270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UM93_04290	COG0667	Aldo Keto reductase
UM93_04295	COG1968	undecaprenyl-diphosphatase activity
UM93_04300	COG0215	cysteine-tRNA ligase activity
UM93_04310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UM93_04325	COG1222	aaa ATPase
UM93_04330	COG4122	O-methyltransferase activity
UM93_04345	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
UM93_04350	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
UM93_04355	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
UM93_04375	COG1113	amino acid transport
UM93_04385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UM93_04390	COG0805	protein transport
UM93_04395	COG4581	dead DEAH box helicase
UM93_04400	COG1574	metal-dependent hydrolase with the TIM-barrel fold
UM93_04405	COG1216	Glycosyl transferase, family 2
UM93_04410	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
UM93_04430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UM93_04440	COG0500	methyltransferase
UM93_04445	COG1506	peptidase
UM93_04445	COG4946	Tricorn protease homolog
UM93_04445	COG0823	Involved in the tonB-independent uptake of proteins
UM93_04450	COG0242	peptide deformylase activity
UM93_04460	COG3265	gluconokinase activity
UM93_04475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
UM93_04490	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
UM93_04500	COG0456	acetyltransferase
UM93_04505	COG0339	signal peptide processing
UM93_04510	COG3422	double-strand break repair
UM93_04515	COG0367	asparagine synthase
UM93_04520	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
UM93_04525	COG0217	transcriptional regulatory protein
UM93_04530	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
UM93_04535	COG0632	four-way junction helicase activity
UM93_04540	COG2255	four-way junction helicase activity
UM93_04555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UM93_04560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
UM93_04570	COG1196	nuclear chromosome segregation
UM93_04580	COG0124	histidyl-tRNA synthetase
UM93_04590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
UM93_04600	COG0456	acetyltransferase
UM93_04625	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
UM93_04640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
UM93_04655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
UM93_04660	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
UM93_04665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
UM93_04670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
UM93_04680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
UM93_04685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UM93_04695	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
UM93_04700	COG0540	Belongs to the ATCase OTCase family
UM93_04705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
UM93_04715	COG0505	Belongs to the CarA family
UM93_04720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
UM93_04725	COG0284	orotidine-5'-phosphate decarboxylase activity
UM93_04730	COG2814	Major facilitator Superfamily
UM93_04740	COG0194	GDP metabolic process
UM93_04745	COG0194	GDP metabolic process
UM93_04750	COG1758	RNA polymerase activity
UM93_04760	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
UM93_04775	COG0596	Alpha beta hydrolase
UM93_04785	COG2390	Transcriptional regulator
UM93_04790	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
UM93_04795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
UM93_04800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
UM93_04810	COG1012	belongs to the aldehyde dehydrogenase family
UM93_04815	COG0495	leucyl-tRNA aminoacylation
UM93_04820	COG1307	EDD domain protein, DegV family
UM93_04840	COG0268	Binds directly to 16S ribosomal RNA
UM93_04850	COG0481	GTPase activity
UM93_04870	COG1420	regulation of RNA biosynthetic process
UM93_04875	COG0484	heat shock protein binding
UM93_04890	COG0583	DNA-binding transcription factor activity
UM93_04905	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
UM93_04915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
UM93_04925	COG3590	peptidase
UM93_04930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UM93_04940	COG1381	Involved in DNA repair and RecF pathway recombination
UM93_04945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
UM93_04950	COG2267	carboxylic ester hydrolase activity
UM93_04965	COG0167	dihydroorotate dehydrogenase activity
UM93_04975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UM93_04985	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
UM93_04990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
UM93_05020	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
UM93_05025	COG0723	plastoquinol--plastocyanin reductase activity
UM93_05030	COG2010	Cytochrome c
UM93_05035	COG1845	cytochrome c oxidase, subunit III
UM93_05040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UM93_05095	COG0028	Belongs to the TPP enzyme family
UM93_05110	COG0583	DNA-binding transcription factor activity
UM93_05140	COG0395	ABC-type sugar transport system, permease component
UM93_05155	COG1309	transcriptional regulator
UM93_05185	COG0640	Transcriptional regulator
UM93_05190	COG0346	lactoylglutathione lyase activity
UM93_05200	COG1073	alpha beta
UM93_05205	COG1595	DNA-templated transcription, initiation
UM93_05235	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
UM93_05305	COG1733	regulation of RNA biosynthetic process
UM93_05360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
UM93_05365	COG4941	Belongs to the sigma-70 factor family
UM93_05370	COG3795	YCII-related domain
UM93_05405	COG0456	acetyltransferase
UM93_05435	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UM93_05445	COG1780	Probably involved in ribonucleotide reductase function
UM93_05455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
UM93_05460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
UM93_05470	COG1231	oxidoreductase activity
UM93_05480	COG1012	belongs to the aldehyde dehydrogenase family
UM93_05485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
UM93_05525	COG0714	Associated with various cellular activities
UM93_05530	COG0318	PFAM AMP-dependent synthetase and ligase
UM93_05545	COG2813	Specifically methylates the guanine in position
UM93_05575	COG1196	nuclear chromosome segregation
UM93_05615	COG0799	negative regulation of ribosome biogenesis
UM93_05625	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
UM93_05635	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
UM93_05640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
UM93_05645	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
UM93_05650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
UM93_05655	COG0261	This protein binds to 23S rRNA in the presence of protein L20
UM93_05665	COG1530	ribonuclease E activity
UM93_05675	COG0180	Tryptophanyl-tRNA synthetase
UM93_05695	COG0105	UTP biosynthetic process
UM93_05705	COG0285	dihydrofolate synthase activity
UM93_05730	COG0525	valine-tRNA ligase activity
UM93_05735	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
UM93_05745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
UM93_05750	COG0740	serine-type endopeptidase activity
UM93_05755	COG0740	serine-type endopeptidase activity
UM93_05765	COG0544	peptidyl-prolyl cis-trans isomerase activity
UM93_05795	COG0698	ribose 5-phosphate isomerase
UM93_05805	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
UM93_05835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UM93_05865	COG1946	Acyl-CoA thioesterase
UM93_06050	COG1902	pentaerythritol trinitrate reductase activity
UM93_06055	COG3022	response to hydroperoxide
UM93_06065	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
UM93_06070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UM93_06080	COG1045	serine acetyltransferase
UM93_06085	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
UM93_06095	COG0583	DNA-binding transcription factor activity
UM93_06115	COG0477	Major facilitator Superfamily
UM93_06125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UM93_06150	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
UM93_06160	COG3340	Belongs to the peptidase S51 family
UM93_06175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UM93_06180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UM93_06185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UM93_06195	COG4974	Belongs to the 'phage' integrase family
UM93_06200	COG0758	DNA mediated transformation
UM93_06205	COG0606	chelatase, subunit chli
UM93_06210	COG0792	nuclease activity
UM93_06220	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
UM93_06230	COG0681	Belongs to the peptidase S26 family
UM93_06235	COG0335	large ribosomal subunit rRNA binding
UM93_06240	COG0336	Belongs to the RNA methyltransferase TrmD family
UM93_06245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
UM93_06250	COG1837	Belongs to the UPF0109 family
UM93_06255	COG0228	four-way junction DNA binding
UM93_06265	COG2514	catechol 2,3-dioxygenase activity
UM93_06290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UM93_06295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
UM93_06310	COG2318	DinB family
UM93_06335	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
UM93_06340	COG0571	ribonuclease III activity
UM93_06345	COG0333	Belongs to the bacterial ribosomal protein bL32 family
UM93_06355	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
UM93_06370	COG0742	ribosomal rna small subunit methyltransferase
UM93_06380	COG1461	Dihydroxyacetone kinase
UM93_06395	COG1181	Belongs to the D-alanine--D-alanine ligase family
UM93_06400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
UM93_06410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
UM93_06415	COG0066	3-isopropylmalate dehydratase activity
UM93_06420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
UM93_06425	COG1414	Transcriptional regulator
UM93_06460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UM93_06465	COG0179	Fumarylacetoacetate (FAA) hydrolase
UM93_06470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UM93_06475	COG0473	3-isopropylmalate dehydrogenase activity
UM93_06480	COG4585	Histidine kinase
UM93_06485	COG2197	response regulator
UM93_06490	COG1136	(ABC) transporter
UM93_06490	COG0577	efflux transmembrane transporter activity
UM93_06495	COG4591	ABC-type transport system involved in lipoprotein release permease component
UM93_06505	COG0640	Transcriptional regulator
UM93_06520	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UM93_06525	COG0440	acetolactate synthase activity
UM93_06535	COG0129	dihydroxy-acid dehydratase activity
UM93_06560	COG2084	Dehydrogenase
UM93_06580	COG0667	Aldo Keto reductase
UM93_06585	COG1902	pentaerythritol trinitrate reductase activity
UM93_06600	COG1309	transcriptional regulator
UM93_06630	COG0747	negative chemotaxis
UM93_06635	COG0579	oxidoreductase
UM93_06640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UM93_06655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UM93_06670	COG1305	Transglutaminase-like
UM93_06675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UM93_06695	COG0442	prolyl-tRNA aminoacylation
UM93_06700	COG1104	cysteine desulfurase activity
UM93_06715	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
UM93_06730	COG1113	amino acid transport
UM93_06740	COG0022	dehydrogenase e1 component
UM93_06745	COG0508	dehydrogenase complex catalyzes the overall conversion of
UM93_06750	COG2267	carboxylic ester hydrolase activity
UM93_06765	COG0515	serine threonine protein kinase
UM93_06770	COG0473	3-isopropylmalate dehydrogenase activity
UM93_06770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
UM93_06780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UM93_06785	COG1012	belongs to the aldehyde dehydrogenase family
UM93_06805	COG1028	Short-chain dehydrogenase reductase Sdr
UM93_06860	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
UM93_06885	COG1012	belongs to the aldehyde dehydrogenase family
UM93_06900	COG0673	inositol 2-dehydrogenase activity
UM93_06925	COG0419	ATPase involved in DNA repair
UM93_06930	COG0420	3'-5' exonuclease activity
UM93_06965	COG1011	Hydrolase
UM93_06975	COG1131	(ABC) transporter
UM93_06985	COG0494	nUDIX hydrolase
UM93_06995	COG0025	NhaP-type Na H and K H
UM93_07005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
UM93_07010	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
UM93_07020	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
UM93_07040	COG1335	isochorismatase
UM93_07060	COG0363	glucosamine-6-phosphate deaminase activity
UM93_07100	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
UM93_07105	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
UM93_07115	COG0789	Transcriptional regulator
UM93_07130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
UM93_07135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
UM93_07140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
UM93_07145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
UM93_07150	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UM93_07155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
UM93_07160	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UM93_07165	COG0356	it plays a direct role in the translocation of protons across the membrane
UM93_07185	COG1216	Glycosyl transferase, family 2
UM93_07195	COG2890	protein-(glutamine-N5) methyltransferase activity
UM93_07200	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
UM93_07210	COG0083	homoserine kinase activity
UM93_07215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
UM93_07220	COG0460	homoserine dehydrogenase
UM93_07225	COG0019	diaminopimelate decarboxylase activity
UM93_07230	COG0018	arginyl-trna synthetase
UM93_07240	COG2807	transmembrane transport
UM93_07255	COG0633	Ferredoxin
UM93_07255	COG0543	2 iron, 2 sulfur cluster binding
UM93_07280	COG1643	Atp-dependent helicase
UM93_07290	COG1064	alcohol dehydrogenase
UM93_07305	COG0454	-acetyltransferase
UM93_07325	COG1121	(ABC) transporter
UM93_07340	COG1253	flavin adenine dinucleotide binding
UM93_07350	COG0508	dehydrogenase complex catalyzes the overall conversion of
UM93_07350	COG0567	Dehydrogenase, E1 component
UM93_07390	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
UM93_07395	COG1162	GTPase activity
UM93_07400	COG0483	inositol monophosphate 1-phosphatase activity
UM93_07405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
UM93_07420	COG1321	iron dependent repressor
UM93_07425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
UM93_07430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
UM93_07450	COG1073	alpha beta
UM93_07475	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
UM93_07480	COG0739	heme binding
UM93_07485	COG2177	Part of the ABC transporter FtsEX involved in
UM93_07490	COG2884	Cell division ATP-binding protein ftsE
UM93_07495	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
UM93_07585	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UM93_07590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UM93_07595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
UM93_07605	COG2089	acid synthase
UM93_07615	COG1083	cytidylyl-transferase
UM93_07640	COG0463	Glycosyl transferase, family 2
UM93_07655	COG2755	lipolytic protein G-D-S-L family
UM93_07655	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
UM93_07680	COG1216	Glycosyl transferase, family 2
UM93_07705	COG2902	Dehydrogenase
UM93_07745	COG0653	protein targeting
UM93_07750	COG3214	Protein conserved in bacteria
UM93_07755	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
UM93_07765	COG5401	PFAM Sporulation and spore germination
UM93_07775	COG0745	RESPONSE REGULATOR receiver
UM93_07800	COG0714	Associated with various cellular activities
UM93_07815	COG0740	serine-type endopeptidase activity
UM93_07820	COG0740	serine-type endopeptidase activity
UM93_07855	COG4172	Belongs to the ABC transporter superfamily
UM93_07860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UM93_07875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
UM93_07875	COG0519	Catalyzes the synthesis of GMP from XMP
UM93_07885	COG0482	sulfurtransferase activity
UM93_07895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UM93_07900	COG2271	Major facilitator Superfamily
UM93_07940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UM93_07945	COG2873	o-acetylhomoserine
UM93_07975	COG2837	iron assimilation
UM93_08005	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
UM93_08010	COG0366	Alpha amylase catalytic
UM93_08010	COG1470	cell adhesion involved in biofilm formation
UM93_08040	COG1228	amidohydrolase
UM93_08050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UM93_08055	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
UM93_08065	COG2986	histidine ammonia-lyase
UM93_08070	COG1280	lysine exporter protein (LysE YggA)
UM93_08095	COG0156	8-amino-7-oxononanoate synthase activity
UM93_08100	COG1063	alcohol dehydrogenase
UM93_08115	COG1028	Short-chain dehydrogenase reductase Sdr
UM93_08140	COG0395	ABC-type sugar transport system, permease component
UM93_08155	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UM93_08160	COG0154	amidase activity
UM93_08165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UM93_08180	COG0484	heat shock protein binding
UM93_08185	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
UM93_08195	COG4106	trans-aconitate 2-methyltransferase activity
UM93_08200	COG1595	DNA-templated transcription, initiation
UM93_08205	COG5343	regulation of RNA biosynthetic process
UM93_08210	COG0789	Transcriptional regulator
UM93_08215	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
UM93_08220	COG2086	electron transfer activity
UM93_08235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UM93_08250	COG1842	Phage shock protein A
UM93_08275	COG0415	Belongs to the DNA photolyase family
UM93_08315	COG3480	Lon protease (S16) C-terminal proteolytic domain
UM93_08365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UM93_08370	COG0765	amino acid transport
UM93_08380	COG0596	Alpha beta hydrolase
UM93_08395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UM93_08405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
UM93_08415	COG0113	porphobilinogen synthase activity
UM93_08425	COG0181	hydroxymethylbilane synthase activity
UM93_08460	COG1309	transcriptional regulator
UM93_08475	COG2022	thiamine diphosphate biosynthetic process
UM93_08510	COG0513	Belongs to the DEAD box helicase family
UM93_08525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UM93_08530	COG4558	Periplasmic binding protein
UM93_08545	COG0613	PHP domain protein
UM93_08550	COG0006	proline dipeptidase activity
UM93_08570	COG2239	Acts as a magnesium transporter
UM93_08585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UM93_08595	COG1595	DNA-templated transcription, initiation
UM93_08615	COG0519	Catalyzes the synthesis of GMP from XMP
UM93_08630	COG1126	abc transporter atp-binding protein
UM93_08635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UM93_08640	COG0765	amino acid transport
UM93_08645	COG0765	amino acid transport
UM93_08660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UM93_08665	COG2171	N-acyltransferase activity
UM93_08700	COG0351	phosphomethylpyrimidine kinase
UM93_08705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UM93_08725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UM93_08730	COG0601	transmembrane transport
UM93_08755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UM93_08765	COG0012	GTP binding
UM93_08770	COG1322	Protein conserved in bacteria
UM93_08775	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
UM93_08785	COG1570	exodeoxyribonuclease VII activity
UM93_08790	COG1722	exodeoxyribonuclease VII activity
UM93_08795	COG2326	polyphosphate kinase activity
UM93_08815	COG1174	glycine betaine transport
UM93_08840	COG0531	amino acid
UM93_08860	COG2971	BadF BadG BcrA BcrD
UM93_08870	COG1522	sequence-specific DNA binding
UM93_08885	COG0598	Magnesium transport protein CorA
UM93_08900	COG0667	Aldo Keto reductase
UM93_08905	COG1309	transcriptional regulator
UM93_08910	COG4221	oxidoreductase activity
UM93_08955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UM93_08980	COG2149	membrane
UM93_09015	COG0583	DNA-binding transcription factor activity
UM93_09100	COG2084	Dehydrogenase
UM93_09105	COG1733	regulation of RNA biosynthetic process
UM93_09130	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UM93_09155	COG0519	Catalyzes the synthesis of GMP from XMP
UM93_09155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
UM93_09170	COG1132	(ABC) transporter
UM93_09175	COG1132	(ABC) transporter
UM93_09225	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
UM93_09225	COG2755	lipolytic protein G-D-S-L family
UM93_09230	COG0459	protein refolding
UM93_09235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
UM93_09245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
UM93_09250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
UM93_09260	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
UM93_09265	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
UM93_09285	COG0604	alcohol dehydrogenase
UM93_09290	COG0802	atpase or kinase
UM93_09295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
UM93_09305	COG1486	melibiose metabolic process
UM93_09320	COG1175	transmembrane transport
UM93_09325	COG0438	transferase activity, transferring glycosyl groups
UM93_09330	COG2759	Belongs to the formate--tetrahydrofolate ligase family
UM93_09335	COG1260	myo-inositol-1-phosphate synthase
UM93_09340	COG0667	Aldo Keto reductase
UM93_09345	COG1609	Transcriptional regulator
UM93_09370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
UM93_09375	COG0509	glycine decarboxylation via glycine cleavage system
UM93_09380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
UM93_09405	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
UM93_09405	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
UM93_09410	COG0736	holo-[acyl-carrier-protein] synthase activity
UM93_09430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
UM93_09435	COG1072	(Pantothenic acid kinase))
UM93_09445	COG1970	mechanosensitive ion channel activity
UM93_09450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UM93_09455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
UM93_09460	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
UM93_09465	COG0101	tRNA pseudouridine synthase activity
UM93_09470	COG0203	ribosomal protein L17
UM93_09475	COG0202	RNA polymerase activity
UM93_09480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
UM93_09485	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
UM93_09490	COG0257	Belongs to the bacterial ribosomal protein bL36 family
UM93_09495	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
UM93_09500	COG3191	aminopeptidase activity
UM93_09505	COG1175	transmembrane transport
UM93_09525	COG1960	acyl-CoA dehydrogenase activity
UM93_09530	COG1028	Short-chain dehydrogenase reductase Sdr
UM93_09540	COG2030	dehydratase
UM93_09545	COG0183	Belongs to the thiolase family
UM93_09555	COG0318	PFAM AMP-dependent synthetase and ligase
UM93_09580	COG0563	adenylate kinase activity
UM93_09590	COG0200	Binds to the 23S rRNA
UM93_09595	COG1841	ribosomal large subunit assembly
UM93_09600	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
UM93_09610	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
UM93_09615	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
UM93_09620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
UM93_09625	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
UM93_09630	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
UM93_09650	COG3268	Saccharopine dehydrogenase
UM93_09655	COG0318	PFAM AMP-dependent synthetase and ligase
UM93_09665	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
UM93_09670	COG0255	Belongs to the universal ribosomal protein uL29 family
UM93_09675	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
UM93_09680	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
UM93_09685	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
UM93_09690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
UM93_09695	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
UM93_09700	COG0089	rRNA binding
UM93_09705	COG0088	Forms part of the polypeptide exit tunnel
UM93_09710	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
UM93_09715	COG0051	transcription antitermination factor activity, RNA binding
UM93_09725	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
UM93_09745	COG2814	Major facilitator Superfamily
UM93_09750	COG0583	DNA-binding transcription factor activity
UM93_09755	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
UM93_09760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
UM93_09765	COG0049	tRNA binding
UM93_09770	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
UM93_09775	COG2356	endonuclease I
UM93_09820	COG0477	Major facilitator Superfamily
UM93_09835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
UM93_09840	COG0085	RNA polymerase activity
UM93_09865	COG0183	Belongs to the thiolase family
UM93_09870	COG0442	prolyl-tRNA aminoacylation
UM93_09885	COG1609	Transcriptional regulator
UM93_09895	COG1175	transmembrane transport
UM93_09910	COG0222	ribosome binding
UM93_09915	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
UM93_09950	COG0081	regulation of translation
UM93_09955	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
UM93_09965	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
UM93_09975	COG0436	Aminotransferase
UM93_09980	COG2197	response regulator
UM93_10015	COG0354	folic acid binding
UM93_10020	COG3485	protocatechuate 3,4-dioxygenase
UM93_10030	COG0745	RESPONSE REGULATOR receiver
UM93_10035	COG0456	acetyltransferase
UM93_10040	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
UM93_10060	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
UM93_10070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
UM93_10100	COG3634	alkyl hydroperoxide reductase activity
UM93_10125	COG1131	(ABC) transporter
UM93_10135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
UM93_10140	COG0738	Major facilitator superfamily
UM93_10150	COG2030	dehydratase
UM93_10160	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
UM93_10175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UM93_10180	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
UM93_10190	COG0583	DNA-binding transcription factor activity
UM93_10210	COG0477	Major facilitator Superfamily
UM93_10225	COG2378	regulation of single-species biofilm formation
UM93_10235	COG2301	Belongs to the HpcH HpaI aldolase family
UM93_10285	COG1733	regulation of RNA biosynthetic process
UM93_10325	COG2258	MOSC domain
UM93_10350	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
UM93_10370	COG0531	amino acid
UM93_10380	COG1228	amidohydrolase
UM93_10385	COG1960	acyl-CoA dehydrogenase activity
UM93_10395	COG1476	TRANSCRIPTIONal
UM93_10420	COG1733	regulation of RNA biosynthetic process
UM93_10435	COG1473	amidohydrolase
UM93_10445	COG1690	Belongs to the RtcB family
UM93_10450	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
UM93_10465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UM93_10475	COG0346	lactoylglutathione lyase activity
UM93_10485	COG1309	transcriptional regulator
UM93_10490	COG1131	(ABC) transporter
UM93_10500	COG2814	Major facilitator Superfamily
UM93_10510	COG0477	Major facilitator Superfamily
UM93_10540	COG1666	GTP binding
UM93_10555	COG2197	response regulator
UM93_10570	COG0477	Major facilitator Superfamily
UM93_10615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
UM93_10630	COG1012	belongs to the aldehyde dehydrogenase family
UM93_10645	COG5002	protein histidine kinase activity
UM93_10650	COG0745	RESPONSE REGULATOR receiver
UM93_10655	COG0671	phosphoesterase, PA-phosphatase related
UM93_10665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
UM93_10665	COG1648	precorrin-2 dehydrogenase activity
UM93_10680	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
UM93_10725	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UM93_10740	COG2860	membrane
UM93_10765	COG2226	methyltransferase
UM93_10795	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
UM93_10800	COG4948	Mandelate Racemase Muconate Lactonizing
UM93_10840	COG0508	dehydrogenase complex catalyzes the overall conversion of
UM93_10845	COG0022	dehydrogenase e1 component
UM93_10870	COG1024	Enoyl-CoA hydratase
UM93_10875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
UM93_10880	COG2151	metal-sulfur cluster biosynthetic enzyme
UM93_10885	COG3396	Phenylacetate-CoA oxygenase
UM93_10890	COG3460	Phenylacetate-CoA oxygenase
UM93_10895	COG3396	Phenylacetate-CoA oxygenase
UM93_10910	COG3591	Belongs to the peptidase S1B family
UM93_10915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UM93_10920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
UM93_10925	COG0857	belongs to the CobB CobQ family
UM93_10925	COG0280	phosphate acetyltransferase
UM93_10960	COG1063	alcohol dehydrogenase
UM93_10965	COG1733	regulation of RNA biosynthetic process
UM93_10970	COG0477	Major facilitator Superfamily
UM93_10985	COG2030	dehydratase
UM93_10985	COG1012	belongs to the aldehyde dehydrogenase family
UM93_10990	COG2226	methyltransferase
UM93_10995	COG2050	protein possibly involved in aromatic compounds catabolism
UM93_11020	COG1250	3-hydroxyacyl-CoA dehydrogenase
UM93_11025	COG1024	Enoyl-CoA hydratase
UM93_11035	COG0488	(ABC) transporter
UM93_11050	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
UM93_11095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UM93_11105	COG0785	Cytochrome C biogenesis protein
UM93_11115	COG0406	alpha-ribazole phosphatase activity
UM93_11120	COG2353	YceI-like domain
UM93_11135	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
UM93_11145	COG0560	Phosphoserine phosphatase
UM93_11155	COG2186	Transcriptional regulator
UM93_11165	COG0640	Transcriptional regulator
UM93_11170	COG0123	including yeast histone deacetylase and acetoin utilization protein
UM93_11175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UM93_11180	COG0569	domain protein
UM93_11185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UM93_11190	COG1082	Xylose isomerase domain protein TIM barrel
UM93_11195	COG0248	Ppx GppA phosphatase
UM93_11200	COG3579	cysteine-type endopeptidase activity
UM93_11205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UM93_11205	COG1754	DNA topoisomerase type I activity
UM93_11210	COG2197	response regulator
UM93_11220	COG2890	protein-(glutamine-N5) methyltransferase activity
UM93_11235	COG1205	dead DEAH box helicase
UM93_11235	COG1111	helicase
UM93_11285	COG0596	Alpha beta hydrolase
UM93_11310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UM93_11320	COG1175	transmembrane transport
UM93_11330	COG1349	DNA-binding transcription factor activity
UM93_11345	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
UM93_11370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UM93_11375	COG1408	metallophosphoesterase
UM93_11380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UM93_11390	COG1132	(ABC) transporter
UM93_11395	COG1132	(ABC) transporter
UM93_11410	COG0765	amino acid transport
UM93_11415	COG0765	amino acid transport
UM93_11430	COG1802	Transcriptional regulator
UM93_11435	COG1960	acyl-CoA dehydrogenase activity
UM93_11440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UM93_11470	COG0477	Major facilitator Superfamily
UM93_11485	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
UM93_11520	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
UM93_11540	COG0542	response to heat
UM93_11560	COG0813	purine-nucleoside phosphorylase activity
UM93_11575	COG0667	Aldo Keto reductase
UM93_11580	COG0531	amino acid
UM93_11600	COG0626	cystathionine gamma-synthase activity
UM93_11605	COG2814	Major facilitator Superfamily
UM93_11610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
UM93_11620	COG0789	Transcriptional regulator
UM93_11625	COG0484	heat shock protein binding
UM93_11630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
UM93_11635	COG0443	Heat shock 70 kDa protein
UM93_11650	COG3896	Chloramphenicol phosphotransferase-like protein
UM93_11660	COG1280	lysine exporter protein (LysE YggA)
UM93_11670	COG1063	alcohol dehydrogenase
UM93_11675	COG1028	Short-chain dehydrogenase reductase Sdr
UM93_11705	COG1609	Transcriptional regulator
UM93_11725	COG4166	transmembrane transport
UM93_11730	COG0601	transmembrane transport
UM93_11740	COG4172	Belongs to the ABC transporter superfamily
UM93_11745	COG0596	Alpha beta hydrolase
UM93_11760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UM93_11785	COG1132	(ABC) transporter
UM93_11830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
UM93_11840	COG1122	ATPase activity
UM93_11845	COG4721	ABC-type cobalt transport system, permease component
UM93_11905	COG0717	Belongs to the dCTP deaminase family
UM93_11910	COG3483	tryptophan 2,3-dioxygenase activity
UM93_11955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
UM93_11960	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
UM93_11970	COG0433	COG0433 Predicted ATPase
UM93_11980	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
UM93_11990	COG1528	Iron-storage protein
UM93_12010	COG0776	regulation of translation
UM93_12015	COG0667	Aldo Keto reductase
UM93_12025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
UM93_12030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
UM93_12035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
UM93_12040	COG2851	Citrate transporter
UM93_12080	COG1028	Short-chain dehydrogenase reductase Sdr
UM93_12080	COG0604	alcohol dehydrogenase
UM93_12080	COG3321	synthase
UM93_12085	COG0604	alcohol dehydrogenase
UM93_12085	COG3321	synthase
UM93_12100	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UM93_12105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UM93_12120	COG0435	Glutathione S-transferase
UM93_12125	COG2814	Major facilitator Superfamily
UM93_12135	COG0702	epimerase
UM93_12150	COG2816	NAD+ diphosphatase activity
UM93_12215	COG0673	inositol 2-dehydrogenase activity
UM93_12225	COG0686	Belongs to the AlaDH PNT family
UM93_12260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UM93_12265	COG0508	dehydrogenase complex catalyzes the overall conversion of
UM93_12270	COG0022	dehydrogenase e1 component
UM93_12280	COG1181	Belongs to the D-alanine--D-alanine ligase family
UM93_12285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
UM93_12290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
UM93_12300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
UM93_12340	COG1505	serine-type exopeptidase activity
UM93_12345	COG0456	acetyltransferase
UM93_12345	COG0454	-acetyltransferase
UM93_12350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UM93_12390	COG1832	CoA-binding protein
UM93_12405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UM93_12420	COG2186	Transcriptional regulator
UM93_12435	COG3254	rhamnose metabolic process
UM93_12450	COG1172	Belongs to the binding-protein-dependent transport system permease family
UM93_12460	COG4948	Mandelate Racemase Muconate Lactonizing
UM93_12475	COG0514	ATP-dependent DNA helicase (RecQ)
UM93_12490	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
UM93_12515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UM93_12535	COG2837	iron assimilation
UM93_12550	COG1511	domain protein
UM93_12555	COG1309	transcriptional regulator
UM93_12580	COG0745	RESPONSE REGULATOR receiver
UM93_12585	COG2205	protein histidine kinase activity
UM93_12610	COG2205	protein histidine kinase activity
UM93_12615	COG0745	RESPONSE REGULATOR receiver
UM93_12630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
UM93_12630	COG2755	lipolytic protein G-D-S-L family
UM93_12640	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
UM93_12685	COG1024	Enoyl-CoA hydratase
UM93_12695	COG1414	Transcriptional regulator
UM93_12720	COG1201	RNA secondary structure unwinding
UM93_12725	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
UM93_12820	COG0343	queuine tRNA-ribosyltransferase activity
UM93_12825	COG0405	Gamma-glutamyltransferase
UM93_12865	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
UM93_12870	COG0352	thiamine-phosphate diphosphorylase activity
UM93_12875	COG0351	phosphomethylpyrimidine kinase
UM93_12875	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
UM93_12875	COG0352	thiamine-phosphate diphosphorylase activity
UM93_12890	COG1733	regulation of RNA biosynthetic process
UM93_12915	COG1716	ATPase activity
UM93_12935	COG0515	serine threonine protein kinase
UM93_12955	COG3764	Sortase (surface protein transpeptidase)
UM93_12965	COG0372	Belongs to the citrate synthase family
UM93_12970	COG0372	Belongs to the citrate synthase family
UM93_12975	COG3511	phospholipase C
UM93_13015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
UM93_13065	COG2261	transglycosylase associated protein
UM93_13070	COG1028	Short-chain dehydrogenase reductase Sdr
UM93_13100	COG2375	cellular response to nickel ion
UM93_13105	COG4592	Periplasmic binding protein
UM93_13110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UM93_13115	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UM93_13120	COG1120	ATPase activity
UM93_13150	COG4585	Histidine kinase
UM93_13155	COG2197	response regulator
UM93_13175	COG4106	trans-aconitate 2-methyltransferase activity
UM93_13185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UM93_13210	COG1132	(ABC) transporter
UM93_13235	COG2076	Multidrug Resistance protein
UM93_13275	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
UM93_13335	COG0745	RESPONSE REGULATOR receiver
UM93_13340	COG1937	Protein conserved in bacteria
UM93_13345	COG2608	mercury ion transmembrane transporter activity
UM93_13355	COG2217	Heavy metal translocating P-type atpase
UM93_13375	COG1609	Transcriptional regulator
UM93_13385	COG4209	transmembrane transport
UM93_13390	COG0395	ABC-type sugar transport system, permease component
UM93_13415	COG0673	inositol 2-dehydrogenase activity
UM93_13430	COG1672	PFAM Archaeal ATPase
UM93_13430	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
UM93_13445	COG0705	Rhomboid family
UM93_13460	COG1215	transferase activity, transferring glycosyl groups
UM93_13480	COG3266	domain, Protein
UM93_13485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
UM93_13490	COG0187	DNA topoisomerase II activity
UM93_13500	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
UM93_13505	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
UM93_13515	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UM93_13520	COG0594	ribonuclease P activity
UM93_13525	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
UM93_13530	COG0706	membrane insertase activity
UM93_13535	COG1847	R3H domain protein
UM93_13540	COG0357	Ribosomal RNA small subunit methyltransferase G
UM93_13545	COG1192	Involved in chromosome partitioning
UM93_13555	COG3118	belongs to the thioredoxin family
UM93_13560	COG0492	ferredoxin-NADP+ reductase activity
UM93_13605	COG2910	NAD(P)H-binding
UM93_13610	COG1733	regulation of RNA biosynthetic process
UM93_13620	COG1609	Transcriptional regulator
UM93_13635	COG1349	DNA-binding transcription factor activity
UM93_13640	COG0738	Major facilitator superfamily
UM93_13665	COG2197	response regulator
UM93_13670	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
UM93_13680	COG1362	aminopeptidase activity
UM93_13690	COG0477	Major facilitator Superfamily
UM93_13700	COG0360	Binds together with S18 to 16S ribosomal RNA
UM93_13710	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
UM93_13715	COG0359	binds to the 23S rRNA
UM93_13730	COG0305	Participates in initiation and elongation during chromosome replication
UM93_13755	COG3938	Belongs to the proline racemase family
UM93_13760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UM93_13780	COG1802	Transcriptional regulator
UM93_13790	COG0006	proline dipeptidase activity
UM93_13820	COG0640	Transcriptional regulator
UM93_13825	COG0534	Mate efflux family protein
UM93_13850	COG4821	SIS domain
UM93_13860	COG1175	transmembrane transport
UM93_13865	COG0395	ABC-type sugar transport system, permease component
UM93_13895	COG0395	ABC-type sugar transport system, permease component
UM93_13915	COG1070	Carbohydrate kinase
UM93_13935	COG0587	DNA-directed DNA polymerase activity
UM93_13960	COG2409	Drug exporters of the RND superfamily
UM93_13965	COG0783	Belongs to the Dps family
UM93_13970	COG0385	Bile acid
UM93_14000	COG2267	carboxylic ester hydrolase activity
UM93_14040	COG1929	Belongs to the glycerate kinase type-1 family
UM93_14085	COG0018	arginyl-trna synthetase
UM93_14100	COG3104	oligopeptide transport
UM93_14105	COG3340	Belongs to the peptidase S51 family
UM93_14110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UM93_14110	COG0425	Belongs to the sulfur carrier protein TusA family
UM93_14120	COG0110	maltose O-acetyltransferase activity
UM93_14125	COG1597	lipid kinase activity
UM93_14130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
UM93_14135	COG0561	phosphatase activity
UM93_14160	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
UM93_14165	COG2027	D-alanyl-D-alanine carboxypeptidase
UM93_14175	COG0037	tRNA processing
UM93_14185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UM93_14190	COG0302	gtp cyclohydrolase
UM93_14200	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
UM93_14205	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
UM93_14230	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
UM93_14235	COG1846	Transcriptional regulator
UM93_14240	COG2814	Major facilitator Superfamily
UM93_14245	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
UM93_14255	COG0542	response to heat
UM93_14260	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
UM93_14270	COG0823	Involved in the tonB-independent uptake of proteins
UM93_14270	COG1506	peptidase
UM93_14270	COG4946	Tricorn protease homolog
UM93_14275	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
UM93_14285	COG2376	Dihydroxyacetone kinase
UM93_14290	COG1461	Dihydroxyacetone kinase
UM93_14295	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
UM93_14295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UM93_14295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM93_14330	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
UM93_14350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
UM93_14365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UM93_14370	COG0306	phosphate transporter
UM93_14710	COG1733	regulation of RNA biosynthetic process
UM93_14750	COG2814	Major facilitator Superfamily
UM93_14825	COG0183	Belongs to the thiolase family
UM93_14835	COG2086	electron transfer activity
UM93_14840	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
UM93_14865	COG0318	PFAM AMP-dependent synthetase and ligase
UM93_14915	COG0300	oxidoreductase activity
UM93_14930	COG0477	Major facilitator Superfamily
UM93_14935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UM93_14960	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
UM93_14965	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
UM93_14970	COG1984	allophanate hydrolase subunit 2
UM93_14975	COG2733	membrane
UM93_14980	COG0584	glycerophosphoryl diester phosphodiesterase
UM93_14985	COG3387	PFAM Glycoside hydrolase 15-related
UM93_15005	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
UM93_15010	COG1028	Short-chain dehydrogenase reductase Sdr
UM93_15025	COG2252	PERMEase
UM93_15030	COG2372	response to copper ion
UM93_15060	COG3883	PFAM NLP P60 protein
UM93_15060	COG0791	NLP P60 protein
UM93_15170	COG1609	Transcriptional regulator
UM93_15175	COG2259	Doxx family
UM93_15195	COG1131	(ABC) transporter
UM93_15210	COG1609	Transcriptional regulator
UM93_15225	COG0395	ABC-type sugar transport system, permease component
UM93_15235	COG0673	inositol 2-dehydrogenase activity
UM93_15245	COG1904	glucuronate isomerase
UM93_15255	COG4948	Mandelate Racemase Muconate Lactonizing
UM93_15275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
UM93_15280	COG0456	acetyltransferase
UM93_15390	COG0191	fructose-bisphosphate aldolase activity
UM93_15415	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
UM93_15420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UM93_15430	COG1832	CoA-binding protein
UM93_15440	COG2315	Protein conserved in bacteria
UM93_15450	COG0010	Belongs to the arginase family
UM93_15460	COG3568	Endonuclease Exonuclease Phosphatase
UM93_15470	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
UM93_15475	COG0047	phosphoribosylformylglycinamidine synthase activity
UM93_15525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UM93_15555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
UM93_15565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UM93_15590	COG2161	toxin-antitoxin pair type II binding
UM93_15600	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
UM93_15605	COG1028	Short-chain dehydrogenase reductase Sdr
UM93_15635	COG0386	Belongs to the glutathione peroxidase family
UM93_15655	COG0438	transferase activity, transferring glycosyl groups
UM93_15660	COG1215	transferase activity, transferring glycosyl groups
UM93_15690	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
UM93_15695	COG1960	acyl-CoA dehydrogenase activity
UM93_15700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UM93_15730	COG1309	transcriptional regulator
UM93_15740	COG0673	inositol 2-dehydrogenase activity
UM93_15750	COG1940	carbohydrate kinase activity
UM93_15790	COG1960	acyl-CoA dehydrogenase activity
UM93_15795	COG1250	3-hydroxyacyl-CoA dehydrogenase
UM93_15805	COG1024	Enoyl-CoA hydratase
UM93_15810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UM93_15815	COG0583	DNA-binding transcription factor activity
UM93_15825	COG0477	Major facilitator Superfamily
UM93_15845	COG0662	Cupin 2, conserved barrel domain protein
UM93_15850	COG1966	Carbon starvation protein
UM93_15875	COG4585	Histidine kinase
UM93_15880	COG2197	response regulator
UM93_15925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
UM93_15930	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
UM93_15950	COG0588	phosphoglycerate mutase activity
UM93_15955	COG0704	Plays a role in the regulation of phosphate uptake
UM93_15980	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
UM93_15985	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
UM93_16035	COG0395	ABC-type sugar transport system, permease component
UM93_16040	COG0366	Alpha amylase catalytic
UM93_16050	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
UM93_16060	COG2986	histidine ammonia-lyase
UM93_16095	COG0277	FAD linked oxidase domain protein
UM93_16110	COG3842	ATPase activity
UM93_16120	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
UM93_16195	COG1302	Protein conserved in bacteria
UM93_16210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
UM93_16230	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
UM93_16265	COG0459	protein refolding
UM93_16270	COG1609	Transcriptional regulator
UM93_16275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
UM93_16285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
UM93_16295	COG2205	protein histidine kinase activity
UM93_16300	COG0745	RESPONSE REGULATOR receiver
UM93_16320	COG1278	Cold shock
UM93_16330	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
UM93_16340	COG0739	heme binding
UM93_16345	COG0791	NLP P60 protein
UM93_16345	COG0741	lytic transglycosylase activity
UM93_16350	COG3103	Sh3 type 3 domain protein
UM93_16350	COG0791	NLP P60 protein
UM93_16350	COG1388	LysM domain
UM93_16370	COG0303	'Molybdopterin
UM93_16380	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
UM93_16390	COG3973	AAA domain
UM93_16395	COG1126	abc transporter atp-binding protein
UM93_16400	COG0765	amino acid transport
UM93_16405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UM93_16410	COG1132	(ABC) transporter
UM93_16435	COG1063	alcohol dehydrogenase
UM93_16465	COG0483	inositol monophosphate 1-phosphatase activity
UM93_16480	COG0045	succinate-CoA ligase (ADP-forming) activity
UM93_16520	COG1082	Xylose isomerase domain protein TIM barrel
UM93_16525	COG0673	inositol 2-dehydrogenase activity
UM93_16535	COG2318	DinB family
UM93_16545	COG3718	enzyme involved in inositol metabolism
UM93_16555	COG0673	inositol 2-dehydrogenase activity
UM93_16565	COG1172	Belongs to the binding-protein-dependent transport system permease family
UM93_16605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UM93_16610	COG1396	sequence-specific DNA binding
UM93_16615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
UM93_16625	COG0028	Belongs to the TPP enzyme family
UM93_16640	COG2261	transglycosylase associated protein
UM93_16665	COG1737	Transcriptional regulator
UM93_16675	COG4948	Mandelate Racemase Muconate Lactonizing
UM93_16690	COG1619	proteins homologs of microcin C7 resistance protein MccF
UM93_16695	COG4172	Belongs to the ABC transporter superfamily
UM93_16700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UM93_16710	COG0747	negative chemotaxis
UM93_16725	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
UM93_16730	COG1737	Transcriptional regulator
UM93_16775	COG0411	ABC transporter
UM93_16800	COG4214	carbohydrate transport
UM93_16850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
UM93_16855	COG4585	Histidine kinase
UM93_16860	COG2197	response regulator