locus-tag	class	description
FFF93_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FFF93_000010	COG0592	DNA-directed DNA polymerase activity
FFF93_000015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FFF93_000020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FFF93_000025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FFF93_000030	COG0187	DNA topoisomerase II activity
FFF93_000035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FFF93_000040	COG3266	domain, Protein
FFF93_000060	COG1215	transferase activity, transferring glycosyl groups
FFF93_000075	COG0705	Rhomboid family
FFF93_000080	COG2818	Glycosylase
FFF93_000095	COG2815	serine threonine protein kinase
FFF93_000095	COG0515	serine threonine protein kinase
FFF93_000100	COG0515	serine threonine protein kinase
FFF93_000105	COG0768	penicillin binding
FFF93_000120	COG1716	ATPase activity
FFF93_000125	COG1716	ATPase activity
FFF93_000205	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FFF93_000210	COG0477	Major facilitator Superfamily
FFF93_000215	COG1984	allophanate hydrolase subunit 2
FFF93_000220	COG4770	biotin carboxylase activity
FFF93_000240	COG0385	Bile acid
FFF93_000250	COG0659	secondary active sulfate transmembrane transporter activity
FFF93_000275	COG3340	Belongs to the peptidase S51 family
FFF93_000290	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FFF93_000310	COG0561	phosphatase activity
FFF93_000320	COG0584	glycerophosphoryl diester phosphodiesterase
FFF93_000325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FFF93_000330	COG0328	RNA-DNA hybrid ribonuclease activity
FFF93_000330	COG0406	alpha-ribazole phosphatase activity
FFF93_000335	COG1929	Belongs to the glycerate kinase type-1 family
FFF93_000340	COG0477	Major facilitator Superfamily
FFF93_000355	COG1028	Short-chain dehydrogenase reductase Sdr
FFF93_000365	COG2233	PERMEase
FFF93_000415	COG0778	Nitroreductase
FFF93_000425	COG3706	GGDEF domain
FFF93_000440	COG0246	Mannitol dehydrogenase
FFF93_000445	COG0395	ABC-type sugar transport system, permease component
FFF93_000455	COG3842	ATPase activity
FFF93_000465	COG1609	Transcriptional regulator
FFF93_000470	COG1904	glucuronate isomerase
FFF93_000475	COG4948	Mandelate Racemase Muconate Lactonizing
FFF93_000480	COG2721	sulfolactate sulfo-lyase activity
FFF93_000485	COG0800	Aldolase
FFF93_000500	COG3104	oligopeptide transport
FFF93_000510	COG0154	amidase activity
FFF93_000515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FFF93_000515	COG0425	Belongs to the sulfur carrier protein TusA family
FFF93_000530	COG1597	lipid kinase activity
FFF93_000535	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FFF93_000540	COG0561	phosphatase activity
FFF93_000560	COG2272	Belongs to the type-B carboxylesterase lipase family
FFF93_000580	COG0037	tRNA processing
FFF93_000590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FFF93_000595	COG0302	gtp cyclohydrolase
FFF93_000635	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FFF93_000640	COG2814	Major facilitator Superfamily
FFF93_000650	COG1435	thymidine kinase activity
FFF93_000660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FFF93_000675	COG0542	response to heat
FFF93_000685	COG1506	peptidase
FFF93_000685	COG0823	Involved in the tonB-independent uptake of proteins
FFF93_000690	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FFF93_000695	COG2376	Dihydroxyacetone kinase
FFF93_000700	COG1461	Dihydroxyacetone kinase
FFF93_000705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FFF93_000705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FFF93_000705	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FFF93_000710	COG1194	a g-specific adenine glycosylase
FFF93_000720	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
FFF93_000725	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FFF93_000730	COG0515	serine threonine protein kinase
FFF93_000755	COG2217	Heavy metal translocating P-type atpase
FFF93_000800	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FFF93_000805	COG0306	phosphate transporter
FFF93_000860	COG2890	protein-(glutamine-N5) methyltransferase activity
FFF93_000870	COG2261	transglycosylase associated protein
FFF93_000875	COG0667	Aldo Keto reductase
FFF93_000880	COG3360	Dodecin
FFF93_000890	COG1937	Protein conserved in bacteria
FFF93_000905	COG2084	Dehydrogenase
FFF93_000910	COG2610	gluconate transmembrane transporter activity
FFF93_000935	COG0300	oxidoreductase activity
FFF93_000945	COG0477	Major facilitator Superfamily
FFF93_000965	COG3285	dna ligase
FFF93_000965	COG1793	dna ligase
FFF93_000970	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FFF93_000990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FFF93_000990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FFF93_000990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FFF93_001000	COG1349	DNA-binding transcription factor activity
FFF93_001030	COG1012	belongs to the aldehyde dehydrogenase family
FFF93_001045	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FFF93_001060	COG1140	nitrate reductase beta subunit
FFF93_001080	COG2733	membrane
FFF93_001110	COG3559	Exporter of polyketide antibiotics
FFF93_001170	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FFF93_001185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FFF93_001185	COG0574	Belongs to the PEP-utilizing enzyme family
FFF93_001190	COG2217	Heavy metal translocating P-type atpase
FFF93_001215	COG1295	ribonuclease BN
FFF93_001250	COG1028	Short-chain dehydrogenase reductase Sdr
FFF93_001255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FFF93_001260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FFF93_001265	COG1116	anion transmembrane transporter activity
FFF93_001265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FFF93_001270	COG1414	Transcriptional regulator
FFF93_001275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FFF93_001305	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FFF93_001330	COG0010	Belongs to the arginase family
FFF93_001335	COG2252	PERMEase
FFF93_001355	COG0574	Belongs to the PEP-utilizing enzyme family
FFF93_001355	COG3848	Pyruvate phosphate dikinase
FFF93_001390	COG0697	spore germination
FFF93_001395	COG0583	DNA-binding transcription factor activity
FFF93_001405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FFF93_001405	COG1796	DNA polymerase
FFF93_001425	COG4974	Belongs to the 'phage' integrase family
FFF93_001590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FFF93_001645	COG1609	Transcriptional regulator
FFF93_001665	COG1024	Enoyl-CoA hydratase
FFF93_001700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FFF93_001705	COG1960	acyl-CoA dehydrogenase activity
FFF93_001710	COG0745	RESPONSE REGULATOR receiver
FFF93_001710	COG3706	GGDEF domain
FFF93_001715	COG2318	DinB family
FFF93_001720	COG1960	acyl-CoA dehydrogenase activity
FFF93_001725	COG0583	DNA-binding transcription factor activity
FFF93_001745	COG1028	Short-chain dehydrogenase reductase Sdr
FFF93_001750	COG0183	Belongs to the thiolase family
FFF93_001760	COG0477	Major facilitator Superfamily
FFF93_001780	COG1280	lysine exporter protein (LysE YggA)
FFF93_001785	COG1278	Cold shock
FFF93_001790	COG0463	Glycosyl transferase, family 2
FFF93_001805	COG0574	Belongs to the PEP-utilizing enzyme family
FFF93_001805	COG3848	Pyruvate phosphate dikinase
FFF93_001830	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FFF93_001845	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FFF93_001860	COG0508	dehydrogenase complex catalyzes the overall conversion of
FFF93_001865	COG0508	dehydrogenase complex catalyzes the overall conversion of
FFF93_001865	COG0022	dehydrogenase e1 component
FFF93_001870	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FFF93_001875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FFF93_001880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FFF93_001905	COG0357	Ribosomal RNA small subunit methyltransferase G
FFF93_001905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FFF93_001915	COG0191	fructose-bisphosphate aldolase activity
FFF93_001935	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FFF93_001960	COG0494	nUDIX hydrolase
FFF93_001965	COG1832	CoA-binding protein
FFF93_001980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FFF93_001985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FFF93_001995	COG1116	anion transmembrane transporter activity
FFF93_002000	COG1832	CoA-binding protein
FFF93_002010	COG2315	Protein conserved in bacteria
FFF93_002015	COG4762	Protein conserved in bacteria
FFF93_002035	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FFF93_002040	COG0047	phosphoribosylformylglycinamidine synthase activity
FFF93_002075	COG1846	Transcriptional regulator
FFF93_002100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FFF93_002125	COG0739	heme binding
FFF93_002125	COG1196	nuclear chromosome segregation
FFF93_002125	COG0741	lytic transglycosylase activity
FFF93_002130	COG0386	Belongs to the glutathione peroxidase family
FFF93_002135	COG1063	alcohol dehydrogenase
FFF93_002140	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FFF93_002145	COG0438	transferase activity, transferring glycosyl groups
FFF93_002210	COG1396	sequence-specific DNA binding
FFF93_002215	COG0028	Belongs to the TPP enzyme family
FFF93_002225	COG0351	phosphomethylpyrimidine kinase
FFF93_002230	COG0477	Major facilitator Superfamily
FFF93_002250	COG0343	queuine tRNA-ribosyltransferase activity
FFF93_002275	COG0477	Major facilitator Superfamily
FFF93_002280	COG0028	Belongs to the TPP enzyme family
FFF93_002285	COG1012	belongs to the aldehyde dehydrogenase family
FFF93_002290	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FFF93_002295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FFF93_002310	COG0671	phosphoesterase, PA-phosphatase related
FFF93_002320	COG3842	ATPase activity
FFF93_002345	COG1960	acyl-CoA dehydrogenase activity
FFF93_002360	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FFF93_002365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FFF93_002380	COG0564	pseudouridine synthase activity
FFF93_002400	COG2364	Membrane
FFF93_002405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FFF93_002410	COG1201	RNA secondary structure unwinding
FFF93_002435	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FFF93_002445	COG0688	phosphatidylethanolamine metabolic process
FFF93_002490	COG2199	diguanylate cyclase activity
FFF93_002490	COG3287	FIST C domain
FFF93_002490	COG2200	EAL domain
FFF93_002510	COG0438	transferase activity, transferring glycosyl groups
FFF93_002520	COG0590	tRNA wobble adenosine to inosine editing
FFF93_002525	COG0671	phosphoesterase, PA-phosphatase related
FFF93_002530	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FFF93_002545	COG2205	protein histidine kinase activity
FFF93_002550	COG0745	RESPONSE REGULATOR receiver
FFF93_002565	COG2062	phosphohistidine phosphatase, SixA
FFF93_002580	COG1309	transcriptional regulator
FFF93_002585	COG1511	domain protein
FFF93_002610	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FFF93_002615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FFF93_002615	COG1017	nitric oxide dioxygenase activity
FFF93_002630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FFF93_002635	COG0514	ATP-dependent DNA helicase (RecQ)
FFF93_002650	COG1505	serine-type exopeptidase activity
FFF93_002665	COG1215	transferase activity, transferring glycosyl groups
FFF93_002675	COG0346	lactoylglutathione lyase activity
FFF93_002710	COG0604	alcohol dehydrogenase
FFF93_002720	COG1966	Carbon starvation protein
FFF93_002740	COG0656	L-ascorbic acid biosynthetic process
FFF93_002780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FFF93_002785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FFF93_002805	COG0588	phosphoglycerate mutase activity
FFF93_002815	COG5002	protein histidine kinase activity
FFF93_002835	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FFF93_002840	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FFF93_002850	COG0215	cysteine-tRNA ligase activity
FFF93_002885	COG0366	Alpha amylase catalytic
FFF93_002895	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FFF93_002920	COG1609	Transcriptional regulator
FFF93_002925	COG0366	Alpha amylase catalytic
FFF93_002935	COG1175	transmembrane transport
FFF93_002940	COG3833	ABC-type maltose transport systems, permease component
FFF93_002945	COG0366	Alpha amylase catalytic
FFF93_002950	COG0277	FAD linked oxidase domain protein
FFF93_002960	COG3842	ATPase activity
FFF93_002980	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FFF93_003000	COG0277	FAD linked oxidase domain protein
FFF93_003005	COG2188	Transcriptional regulator
FFF93_003010	COG1620	l-lactate permease
FFF93_003015	COG0247	lactate metabolic process
FFF93_003025	COG1556	Lactate utilization protein
FFF93_003050	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
FFF93_003060	COG1256	bacterial-type flagellum assembly
FFF93_003060	COG4786	Flagellar basal body rod
FFF93_003070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FFF93_003075	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FFF93_003090	COG1815	bacterial-type flagellum-dependent cell motility
FFF93_003095	COG1558	bacterial-type flagellum-dependent cell motility
FFF93_003100	COG1677	Flagellar hook-basal body complex protein FliE
FFF93_003105	COG1766	The M ring may be actively involved in energy transduction
FFF93_003110	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FFF93_003120	COG1157	protein secretion by the type III secretion system
FFF93_003130	COG0791	NLP P60 protein
FFF93_003140	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FFF93_003150	COG2124	cytochrome p450
FFF93_003165	COG1360	Flagellar Motor Protein
FFF93_003175	COG1776	CheC inhibitor of MCP methylation
FFF93_003175	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FFF93_003185	COG1338	Plays a role in the flagellum-specific transport system
FFF93_003190	COG1987	bacterial-type flagellum assembly
FFF93_003200	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FFF93_003205	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FFF93_003215	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FFF93_003230	COG0783	Belongs to the Dps family
FFF93_003235	COG0477	Major facilitator Superfamily
FFF93_003245	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FFF93_003245	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FFF93_003250	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FFF93_003255	COG0509	glycine decarboxylation via glycine cleavage system
FFF93_003260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FFF93_003270	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FFF93_003290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FFF93_003305	COG1278	Cold shock
FFF93_003315	COG0459	protein refolding
FFF93_003330	COG2205	protein histidine kinase activity
FFF93_003335	COG0745	RESPONSE REGULATOR receiver
FFF93_003355	COG1278	Cold shock
FFF93_003365	COG2814	Major facilitator Superfamily
FFF93_003380	COG0739	heme binding
FFF93_003400	COG0303	'Molybdopterin
FFF93_003405	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FFF93_003430	COG0488	(ABC) transporter
FFF93_003435	COG1132	(ABC) transporter
FFF93_003440	COG0494	nUDIX hydrolase
FFF93_003480	COG0483	inositol monophosphate 1-phosphatase activity
FFF93_003495	COG0045	succinate-CoA ligase (ADP-forming) activity
FFF93_003510	COG0640	Transcriptional regulator
FFF93_003515	COG1846	Transcriptional regulator
FFF93_003520	COG2814	Major facilitator Superfamily
FFF93_003525	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FFF93_003575	COG0028	Belongs to the TPP enzyme family
FFF93_003610	COG1401	restriction endodeoxyribonuclease activity
FFF93_003650	COG1902	pentaerythritol trinitrate reductase activity
FFF93_003665	COG2183	response to ionizing radiation
FFF93_003695	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FFF93_003705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FFF93_003730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FFF93_003735	COG0667	Aldo Keto reductase
FFF93_003785	COG1254	Belongs to the acylphosphatase family
FFF93_003800	COG0477	Major facilitator Superfamily
FFF93_003845	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FFF93_003865	COG0366	Alpha amylase catalytic
FFF93_003920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FFF93_003930	COG2072	flavoprotein involved in K transport
FFF93_003970	COG3619	membrane
FFF93_003975	COG0747	negative chemotaxis
FFF93_003980	COG0601	transmembrane transport
FFF93_003995	COG4172	Belongs to the ABC transporter superfamily
FFF93_004000	COG1802	Transcriptional regulator
FFF93_004005	COG1278	Cold shock
FFF93_004030	COG1929	Belongs to the glycerate kinase type-1 family
FFF93_004035	COG1301	dicarboxylic acid transport
FFF93_004070	COG5001	Diguanylate cyclase
FFF93_004075	COG5001	Diguanylate cyclase
FFF93_004085	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FFF93_004100	COG2268	Band 7 protein
FFF93_004130	COG0477	Major facilitator Superfamily
FFF93_004135	COG0138	bifunctional purine biosynthesis protein purh
FFF93_004145	COG2838	Isocitrate dehydrogenase
FFF93_004160	COG2815	serine threonine protein kinase
FFF93_004160	COG0515	serine threonine protein kinase
FFF93_004180	COG4213	ABC transporter substrate-binding protein
FFF93_004190	COG1129	ABC transporter
FFF93_004225	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FFF93_004230	COG1131	(ABC) transporter
FFF93_004260	COG0180	Tryptophanyl-tRNA synthetase
FFF93_004280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FFF93_004295	COG2009	succinate dehydrogenase
FFF93_004305	COG1473	amidohydrolase
FFF93_004305	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FFF93_004310	COG1846	Transcriptional regulator
FFF93_004315	COG1764	response to oxidative stress
FFF93_004320	COG2130	NADP-dependent
FFF93_004325	COG1744	ABC transporter substrate-binding protein PnrA-like
FFF93_004360	COG0586	Pfam SNARE associated Golgi protein
FFF93_004365	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FFF93_004370	COG3956	TIGRFAM MazG family protein
FFF93_004375	COG0148	phosphopyruvate hydratase activity
FFF93_004400	COG1252	NADH dehydrogenase
FFF93_004450	COG0183	Belongs to the thiolase family
FFF93_004455	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FFF93_004465	COG2017	converts alpha-aldose to the beta-anomer
FFF93_004475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FFF93_004485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FFF93_004495	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FFF93_004505	COG1331	Highly conserved protein containing a thioredoxin domain
FFF93_004510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FFF93_004520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FFF93_004525	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FFF93_004545	COG0114	fumarate hydratase activity
FFF93_004550	COG0288	reversible hydration of carbon dioxide
FFF93_004560	COG1494	fructose-1,6-bisphosphatase
FFF93_004575	COG1482	cell wall glycoprotein biosynthetic process
FFF93_004635	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FFF93_004695	COG0714	Associated with various cellular activities
FFF93_004700	COG0084	hydrolase, TatD family'
FFF93_004705	COG3583	domain protein
FFF93_004710	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FFF93_004715	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FFF93_004720	COG0488	(ABC) transporter
FFF93_004725	COG1309	transcriptional regulator
FFF93_004735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FFF93_004745	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FFF93_004750	COG0193	aminoacyl-tRNA hydrolase activity
FFF93_004755	COG4566	intracellular signal transduction
FFF93_004760	COG2197	response regulator
FFF93_004805	COG4412	M6 family metalloprotease domain protein
FFF93_004805	COG3291	Pkd domain containing protein
FFF93_004850	COG0822	iron-sulfur transferase activity
FFF93_004855	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FFF93_004875	COG0702	epimerase
FFF93_004885	COG1988	membrane-bound metal-dependent
FFF93_004895	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FFF93_004925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FFF93_004930	COG1959	2 iron, 2 sulfur cluster binding
FFF93_004945	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FFF93_004980	COG0300	oxidoreductase activity
FFF93_005015	COG0243	molybdopterin cofactor binding
FFF93_005020	COG2223	nitrite transmembrane transporter activity
FFF93_005040	COG0477	Major facilitator Superfamily
FFF93_005050	COG4770	biotin carboxylase activity
FFF93_005055	COG0424	maF-like protein
FFF93_005080	COG2409	Drug exporters of the RND superfamily
FFF93_005115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FFF93_005120	COG1028	Short-chain dehydrogenase reductase Sdr
FFF93_005125	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FFF93_005125	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FFF93_005140	COG0631	protein serine/threonine phosphatase activity
FFF93_005145	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FFF93_005150	COG0483	inositol monophosphate 1-phosphatase activity
FFF93_005165	COG4565	transcriptional regulatory protein
FFF93_005175	COG2851	Citrate transporter
FFF93_005180	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FFF93_005185	COG0154	amidase activity
FFF93_005190	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FFF93_005195	COG0583	DNA-binding transcription factor activity
FFF93_005200	COG1063	alcohol dehydrogenase
FFF93_005205	COG0156	8-amino-7-oxononanoate synthase activity
FFF93_005215	COG1228	amidohydrolase
FFF93_005245	COG2873	o-acetylhomoserine
FFF93_005250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FFF93_005290	COG0400	carboxylic ester hydrolase activity
FFF93_005305	COG0423	glycine-tRNA ligase activity
FFF93_005315	COG2031	fatty acid transporter
FFF93_005320	COG0204	Acyl-transferase
FFF93_005350	COG0358	DNA primase activity
FFF93_005370	COG2814	Major facilitator Superfamily
FFF93_005380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FFF93_005390	COG0297	glycogen (starch) synthase activity
FFF93_005415	COG0052	Belongs to the universal ribosomal protein uS2 family
FFF93_005420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FFF93_005425	COG0528	UMP kinase activity
FFF93_005430	COG0233	cytoplasmic translational termination
FFF93_005435	COG0575	Belongs to the CDS family
FFF93_005445	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FFF93_005460	COG3275	phosphorelay sensor kinase activity
FFF93_005470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FFF93_005485	COG0022	dehydrogenase e1 component
FFF93_005490	COG0508	dehydrogenase complex catalyzes the overall conversion of
FFF93_005500	COG1733	regulation of RNA biosynthetic process
FFF93_005510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FFF93_005520	COG1960	acyl-CoA dehydrogenase activity
FFF93_005545	COG4565	transcriptional regulatory protein
FFF93_005550	COG3290	protein histidine kinase activity
FFF93_005570	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FFF93_005575	COG0750	zinc metalloprotease
FFF93_005595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FFF93_005605	COG0442	prolyl-tRNA aminoacylation
FFF93_005635	COG0779	Required for maturation of 30S ribosomal subunits
FFF93_005650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FFF93_005655	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FFF93_005660	COG3118	belongs to the thioredoxin family
FFF93_005680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FFF93_005740	COG3483	tryptophan 2,3-dioxygenase activity
FFF93_005750	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FFF93_005755	COG1185	polyribonucleotide nucleotidyltransferase activity
FFF93_005760	COG0612	Peptidase, M16
FFF93_005775	COG0411	ABC transporter
FFF93_005780	COG0410	ABC transporter
FFF93_005785	COG0559	Belongs to the binding-protein-dependent transport system permease family
FFF93_005795	COG0318	PFAM AMP-dependent synthetase and ligase
FFF93_005835	COG0521	Mo-molybdopterin cofactor biosynthetic process
FFF93_005845	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FFF93_005860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FFF93_005870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FFF93_005875	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FFF93_005880	COG1674	ftsk spoiiie
FFF93_005890	COG1546	Belongs to the CinA family
FFF93_005890	COG1058	Belongs to the CinA family
FFF93_005895	COG1396	sequence-specific DNA binding
FFF93_005910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FFF93_005915	COG2137	regulation of response to DNA damage stimulus
FFF93_005920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FFF93_005925	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FFF93_005930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FFF93_005935	COG2813	Specifically methylates the guanine in position
FFF93_005940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FFF93_005950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FFF93_005960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FFF93_005965	COG0131	Imidazoleglycerol-phosphate dehydratase
FFF93_005970	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FFF93_005975	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FFF93_005995	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FFF93_006000	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FFF93_006005	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FFF93_006010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FFF93_006015	COG2261	transglycosylase associated protein
FFF93_006025	COG2814	Major facilitator Superfamily
FFF93_006035	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FFF93_006040	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FFF93_006045	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FFF93_006060	COG2197	response regulator
FFF93_006070	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FFF93_006085	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FFF93_006090	COG0072	phenylalanine-tRNA ligase activity
FFF93_006090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FFF93_006120	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FFF93_006125	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FFF93_006130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FFF93_006135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FFF93_006140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FFF93_006145	COG1438	arginine binding
FFF93_006150	COG0137	argininosuccinate synthase activity
FFF93_006155	COG0165	Argininosuccinate lyase
FFF93_006160	COG0259	pyridoxamine-phosphate oxidase activity
FFF93_006170	COG2169	Transcriptional regulator
FFF93_006170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FFF93_006180	COG2094	Belongs to the DNA glycosylase MPG family
FFF93_006190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FFF93_006200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FFF93_006235	COG0647	UMP catabolic process
FFF93_006250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FFF93_006255	COG0497	DNA recombination
FFF93_006260	COG0504	CTP synthase activity
FFF93_006285	COG1595	DNA-templated transcription, initiation
FFF93_006305	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FFF93_006310	COG2079	MmgE PrpD family protein
FFF93_006330	COG3290	protein histidine kinase activity
FFF93_006345	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FFF93_006350	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FFF93_006365	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FFF93_006375	COG1160	GTP binding
FFF93_006385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FFF93_006390	COG0509	glycine decarboxylation via glycine cleavage system
FFF93_006420	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FFF93_006430	COG1940	carbohydrate kinase activity
FFF93_006455	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FFF93_006460	COG0515	serine threonine protein kinase
FFF93_006460	COG2815	serine threonine protein kinase
FFF93_006465	COG1388	LysM domain
FFF93_006465	COG3942	CHAP domain
FFF93_006475	COG0142	geranyltranstransferase activity
FFF93_006495	COG2001	Belongs to the MraZ family
FFF93_006500	COG0275	rRNA processing
FFF93_006510	COG0768	penicillin binding
FFF93_006525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FFF93_006530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FFF93_006540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FFF93_006545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FFF93_006555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FFF93_006570	COG1799	cell septum assembly
FFF93_006580	COG3599	regulation of cell shape
FFF93_006585	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FFF93_006610	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FFF93_006615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FFF93_006620	COG1028	Short-chain dehydrogenase reductase Sdr
FFF93_006640	COG2353	YceI-like domain
FFF93_006645	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FFF93_006650	COG0174	glutamine synthetase
FFF93_006655	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FFF93_006695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FFF93_006700	COG0321	lipoyl(octanoyl) transferase activity
FFF93_006710	COG1090	epimerase
FFF93_006715	COG4946	Tricorn protease homolog
FFF93_006715	COG0793	Belongs to the peptidase S41A family
FFF93_006720	COG1764	response to oxidative stress
FFF93_006730	COG0508	dehydrogenase complex catalyzes the overall conversion of
FFF93_006735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FFF93_006740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FFF93_006760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FFF93_006785	COG1271	oxidase subunit
FFF93_006790	COG1294	oxidase, subunit
FFF93_006795	COG4988	ABC transporter
FFF93_006815	COG1131	(ABC) transporter
FFF93_006825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FFF93_006830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FFF93_006830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FFF93_006860	COG0756	dUTP diphosphatase activity
FFF93_006885	COG0569	domain protein
FFF93_006890	COG0531	amino acid
FFF93_006895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FFF93_006900	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FFF93_006905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FFF93_006920	COG0667	Aldo Keto reductase
FFF93_006940	COG1122	ATPase activity
FFF93_006950	COG1136	(ABC) transporter
FFF93_006950	COG0577	efflux transmembrane transporter activity
FFF93_006955	COG0577	efflux transmembrane transporter activity
FFF93_006955	COG1136	(ABC) transporter
FFF93_006970	COG1250	3-hydroxyacyl-CoA dehydrogenase
FFF93_006970	COG1024	Enoyl-CoA hydratase
FFF93_006975	COG0183	Belongs to the thiolase family
FFF93_006980	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FFF93_007005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FFF93_007020	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FFF93_007080	COG0242	peptide deformylase activity
FFF93_007085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FFF93_007095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FFF93_007110	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FFF93_007110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FFF93_007120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FFF93_007125	COG0140	phosphoribosyl-ATP diphosphatase activity
FFF93_007130	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FFF93_007135	COG0107	imidazoleglycerol-phosphate synthase activity
FFF93_007145	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FFF93_007165	COG0134	indole-3-glycerol-phosphate synthase activity
FFF93_007170	COG0133	tryptophan synthase activity
FFF93_007175	COG0159	tryptophan synthase activity
FFF93_007180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FFF93_007185	COG0069	glutamate synthase activity
FFF93_007185	COG0067	glutamate synthase
FFF93_007185	COG0070	glutamate synthase
FFF93_007195	COG0469	pyruvate kinase activity
FFF93_007220	COG4829	muconolactone delta-isomerase
FFF93_007240	COG0501	Belongs to the peptidase M48B family
FFF93_007280	COG2084	Dehydrogenase
FFF93_007285	COG0667	Aldo Keto reductase
FFF93_007295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FFF93_007305	COG1846	Transcriptional regulator
FFF93_007330	COG0640	Transcriptional regulator
FFF93_007360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FFF93_007390	COG0693	protein deglycase activity
FFF93_007400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FFF93_007405	COG1695	Transcriptional regulator
FFF93_007425	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FFF93_007430	COG1620	l-lactate permease
FFF93_007435	COG0277	FAD linked oxidase domain protein
FFF93_007440	COG1414	Transcriptional regulator
FFF93_007445	COG0477	Major facilitator Superfamily
FFF93_007450	COG0583	DNA-binding transcription factor activity
FFF93_007455	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FFF93_007460	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FFF93_007465	COG1028	Short-chain dehydrogenase reductase Sdr
FFF93_007470	COG0824	Thioesterase
FFF93_007480	COG1024	Enoyl-CoA hydratase
FFF93_007490	COG1960	acyl-CoA dehydrogenase activity
FFF93_007495	COG1250	3-hydroxyacyl-CoA dehydrogenase
FFF93_007500	COG1024	Enoyl-CoA hydratase
FFF93_007510	COG0318	PFAM AMP-dependent synthetase and ligase
FFF93_007515	COG0183	Belongs to the thiolase family
FFF93_007520	COG1960	acyl-CoA dehydrogenase activity
FFF93_007540	COG0405	Gamma-glutamyltransferase
FFF93_007565	COG1064	alcohol dehydrogenase
FFF93_007580	COG1643	Atp-dependent helicase
FFF93_007610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FFF93_007615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FFF93_007625	COG0745	RESPONSE REGULATOR receiver
FFF93_007630	COG2205	protein histidine kinase activity
FFF93_007650	COG0586	Pfam SNARE associated Golgi protein
FFF93_007675	COG2226	methyltransferase
FFF93_007695	COG0009	L-threonylcarbamoyladenylate synthase
FFF93_007700	COG1028	Short-chain dehydrogenase reductase Sdr
FFF93_007705	COG2249	NAD(P)H dehydrogenase (quinone) activity
FFF93_007725	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FFF93_007735	COG3608	succinylglutamate desuccinylase aspartoacylase
FFF93_007735	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FFF93_007755	COG0583	DNA-binding transcription factor activity
FFF93_007770	COG0318	PFAM AMP-dependent synthetase and ligase
FFF93_007775	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FFF93_007785	COG0589	response to stress
FFF93_007805	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FFF93_007810	COG2050	protein possibly involved in aromatic compounds catabolism
FFF93_007820	COG4552	Acetyltransferase involved in intracellular survival and related
FFF93_007830	COG0539	negative regulation of cytoplasmic translation
FFF93_007845	COG1739	Uncharacterized protein family UPF0029
FFF93_007850	COG0237	dephospho-CoA kinase activity
FFF93_007850	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FFF93_007855	COG0556	nucleotide-excision repair
FFF93_007860	COG0861	Integral membrane protein TerC family
FFF93_007895	COG4106	trans-aconitate 2-methyltransferase activity
FFF93_007900	COG1132	(ABC) transporter
FFF93_007920	COG0546	phosphoglycolate phosphatase activity
FFF93_007930	COG0322	excinuclease ABC activity
FFF93_007935	COG1660	Displays ATPase and GTPase activities
FFF93_007940	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FFF93_007945	COG1481	regulation of sporulation
FFF93_007950	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FFF93_007960	COG0126	phosphoglycerate kinase activity
FFF93_007965	COG0149	triose-phosphate isomerase activity
FFF93_007970	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FFF93_007980	COG0363	glucosamine-6-phosphate deaminase activity
FFF93_007995	COG0166	Belongs to the GPI family
FFF93_008000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FFF93_008010	COG0109	protoheme IX farnesyltransferase activity
FFF93_008015	COG0586	Pfam SNARE associated Golgi protein
FFF93_008020	COG1612	heme a metabolic process
FFF93_008030	COG1131	(ABC) transporter
FFF93_008055	COG0396	ATPase activity
FFF93_008060	COG2151	metal-sulfur cluster biosynthetic enzyme
FFF93_008070	COG0318	PFAM AMP-dependent synthetase and ligase
FFF93_008075	COG0183	Belongs to the thiolase family
FFF93_008085	COG1122	ATPase activity
FFF93_008090	COG1268	BioY protein
FFF93_008095	COG0488	(ABC) transporter
FFF93_008120	COG1028	Short-chain dehydrogenase reductase Sdr
FFF93_008135	COG1028	Short-chain dehydrogenase reductase Sdr
FFF93_008140	COG3830	Belongs to the UPF0237 family
FFF93_008140	COG0560	Phosphoserine phosphatase
FFF93_008145	COG1119	ATPase activity
FFF93_008160	COG0254	rRNA binding
FFF93_008175	COG2855	membrane
FFF93_008180	COG2308	Evidence 4 Homologs of previously reported genes of
FFF93_008225	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FFF93_008230	COG0297	glycogen (starch) synthase activity
FFF93_008245	COG0183	Belongs to the thiolase family
FFF93_008250	COG1028	Short-chain dehydrogenase reductase Sdr
FFF93_008270	COG0435	Glutathione S-transferase
FFF93_008315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FFF93_008350	COG0656	L-ascorbic acid biosynthetic process
FFF93_008355	COG1968	undecaprenyl-diphosphatase activity
FFF93_008360	COG0215	cysteine-tRNA ligase activity
FFF93_008375	COG1994	Peptidase M50
FFF93_008375	COG0517	IMP dehydrogenase activity
FFF93_008385	COG1222	aaa ATPase
FFF93_008390	COG4122	O-methyltransferase activity
FFF93_008400	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FFF93_008405	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FFF93_008410	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FFF93_008415	COG0545	Peptidyl-prolyl cis-trans isomerase
FFF93_008435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FFF93_008440	COG0805	protein transport
FFF93_008445	COG4581	dead DEAH box helicase
FFF93_008450	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FFF93_008455	COG1216	Glycosyl transferase, family 2
FFF93_008480	COG1506	peptidase
FFF93_008480	COG4946	Tricorn protease homolog
FFF93_008480	COG0823	Involved in the tonB-independent uptake of proteins
FFF93_008485	COG0242	peptide deformylase activity
FFF93_008505	COG3424	synthase
FFF93_008510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FFF93_008535	COG1335	isochorismatase
FFF93_008550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FFF93_008555	COG1845	cytochrome c oxidase, subunit III
FFF93_008560	COG2010	Cytochrome c
FFF93_008565	COG0723	plastoquinol--plastocyanin reductase activity
FFF93_008570	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FFF93_008575	COG2188	Transcriptional regulator
FFF93_008580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FFF93_008590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FFF93_008595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FFF93_008605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FFF93_008615	COG0167	dihydroorotate dehydrogenase activity
FFF93_008640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FFF93_008645	COG1381	Involved in DNA repair and RecF pathway recombination
FFF93_008650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FFF93_008655	COG3590	peptidase
FFF93_008660	COG1316	TRANSCRIPTIONal
FFF93_008665	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FFF93_008675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FFF93_008690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FFF93_008695	COG0484	heat shock protein binding
FFF93_008700	COG1420	regulation of RNA biosynthetic process
FFF93_008715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FFF93_008720	COG0481	GTPase activity
FFF93_008730	COG0268	Binds directly to 16S ribosomal RNA
FFF93_008745	COG2183	response to ionizing radiation
FFF93_008750	COG1307	EDD domain protein, DegV family
FFF93_008755	COG0495	leucyl-tRNA aminoacylation
FFF93_008780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FFF93_008785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FFF93_008790	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FFF93_008800	COG0656	L-ascorbic acid biosynthetic process
FFF93_008810	COG0438	transferase activity, transferring glycosyl groups
FFF93_008820	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FFF93_008830	COG1758	RNA polymerase activity
FFF93_008835	COG0194	GDP metabolic process
FFF93_008840	COG0194	GDP metabolic process
FFF93_008845	COG0284	orotidine-5'-phosphate decarboxylase activity
FFF93_008850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FFF93_008855	COG0505	Belongs to the CarA family
FFF93_008865	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FFF93_008870	COG0540	Belongs to the ATCase OTCase family
FFF93_008875	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FFF93_008885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FFF93_008890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FFF93_008900	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FFF93_008905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FFF93_008910	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FFF93_008915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FFF93_008930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FFF93_008945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FFF93_008960	COG0456	acetyltransferase
FFF93_008965	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FFF93_008975	COG0124	histidyl-tRNA synthetase
FFF93_008985	COG1196	nuclear chromosome segregation
FFF93_008995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FFF93_009000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FFF93_009005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FFF93_009015	COG2255	four-way junction helicase activity
FFF93_009020	COG0632	four-way junction helicase activity
FFF93_009025	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FFF93_009030	COG0217	transcriptional regulatory protein
FFF93_009035	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FFF93_009040	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FFF93_009070	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FFF93_009085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FFF93_009090	COG0587	DNA-directed DNA polymerase activity
FFF93_009105	COG1605	Chorismate mutase
FFF93_009105	COG0077	Prephenate dehydratase
FFF93_009115	COG2135	peptidase activity
FFF93_009180	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FFF93_009185	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FFF93_009190	COG0671	phosphoesterase, PA-phosphatase related
FFF93_009195	COG0586	Pfam SNARE associated Golgi protein
FFF93_009200	COG0745	RESPONSE REGULATOR receiver
FFF93_009205	COG2205	protein histidine kinase activity
FFF93_009215	COG0569	domain protein
FFF93_009215	COG0475	glutathione-regulated potassium exporter activity
FFF93_009265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FFF93_009325	COG0730	response to heat
FFF93_009335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FFF93_009345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FFF93_009365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FFF93_009370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FFF93_009380	COG0412	Dienelactone hydrolase
FFF93_009385	COG1473	amidohydrolase
FFF93_009390	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FFF93_009395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FFF93_009415	COG1250	3-hydroxyacyl-CoA dehydrogenase
FFF93_009420	COG1309	transcriptional regulator
FFF93_009430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FFF93_009435	COG1028	Short-chain dehydrogenase reductase Sdr
FFF93_009450	COG3384	dioxygenase
FFF93_009530	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FFF93_009540	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FFF93_009550	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FFF93_009555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FFF93_009560	COG1780	Probably involved in ribonucleotide reductase function
FFF93_009570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FFF93_009575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FFF93_009585	COG0493	'glutamate synthase
FFF93_009595	COG1012	belongs to the aldehyde dehydrogenase family
FFF93_009605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FFF93_009630	COG0492	ferredoxin-NADP+ reductase activity
FFF93_009655	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FFF93_009665	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FFF93_009670	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FFF93_009675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FFF93_009680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FFF93_009685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FFF93_009690	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FFF93_009690	COG0352	thiamine-phosphate diphosphorylase activity
FFF93_009690	COG0351	phosphomethylpyrimidine kinase
FFF93_009695	COG1530	ribonuclease E activity
FFF93_009705	COG0105	UTP biosynthetic process
FFF93_009715	COG0285	dihydrofolate synthase activity
FFF93_009720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FFF93_009725	COG0584	glycerophosphoryl diester phosphodiesterase
FFF93_009735	COG3189	MarR family transcriptional regulator
FFF93_009740	COG0525	valine-tRNA ligase activity
FFF93_009750	COG3387	PFAM Glycoside hydrolase 15-related
FFF93_009755	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FFF93_009760	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FFF93_009765	COG0740	serine-type endopeptidase activity
FFF93_009770	COG0740	serine-type endopeptidase activity
FFF93_009775	COG0544	peptidyl-prolyl cis-trans isomerase activity
FFF93_009820	COG0668	transmembrane transport
FFF93_009835	COG0456	acetyltransferase
FFF93_009845	COG1946	Acyl-CoA thioesterase
FFF93_009865	COG0598	Magnesium transport protein CorA
FFF93_009870	COG5416	Lipopolysaccharide assembly protein A domain
FFF93_009905	COG0242	peptide deformylase activity
FFF93_009910	COG2326	polyphosphate kinase activity
FFF93_009975	COG3022	response to hydroperoxide
FFF93_009985	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FFF93_009990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FFF93_010000	COG1045	serine acetyltransferase
FFF93_010010	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FFF93_010050	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FFF93_010065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FFF93_010070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FFF93_010085	COG4974	Belongs to the 'phage' integrase family
FFF93_010095	COG0606	chelatase, subunit chli
FFF93_010100	COG0792	nuclease activity
FFF93_010110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FFF93_010120	COG0681	Belongs to the peptidase S26 family
FFF93_010125	COG0335	large ribosomal subunit rRNA binding
FFF93_010130	COG0336	Belongs to the RNA methyltransferase TrmD family
FFF93_010135	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FFF93_010140	COG1837	Belongs to the UPF0109 family
FFF93_010145	COG0228	four-way junction DNA binding
FFF93_010155	COG2514	catechol 2,3-dioxygenase activity
FFF93_010185	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FFF93_010200	COG2814	Major facilitator Superfamily
FFF93_010215	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FFF93_010220	COG0571	ribonuclease III activity
FFF93_010225	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FFF93_010235	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FFF93_010240	COG0300	oxidoreductase activity
FFF93_010255	COG0742	ribosomal rna small subunit methyltransferase
FFF93_010265	COG1461	Dihydroxyacetone kinase
FFF93_010280	COG1088	dTDP-glucose 4,6-dehydratase activity
FFF93_010285	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FFF93_010295	COG1181	Belongs to the D-alanine--D-alanine ligase family
FFF93_010300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FFF93_010310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FFF93_010325	COG0066	3-isopropylmalate dehydratase activity
FFF93_010330	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FFF93_010335	COG1414	Transcriptional regulator
FFF93_010375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FFF93_010380	COG0179	Fumarylacetoacetate (FAA) hydrolase
FFF93_010390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FFF93_010395	COG0473	3-isopropylmalate dehydrogenase activity
FFF93_010415	COG0577	efflux transmembrane transporter activity
FFF93_010415	COG1136	(ABC) transporter
FFF93_010425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FFF93_010430	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FFF93_010435	COG0440	acetolactate synthase activity
FFF93_010445	COG0129	dihydroxy-acid dehydratase activity
FFF93_010455	COG0228	four-way junction DNA binding
FFF93_010510	COG0798	PFAM Bile acid sodium symporter
FFF93_010535	COG0747	negative chemotaxis
FFF93_010540	COG0579	oxidoreductase
FFF93_010545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FFF93_010550	COG2814	Major facilitator Superfamily
FFF93_010555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FFF93_010565	COG1305	Transglutaminase-like
FFF93_010590	COG1104	cysteine desulfurase activity
FFF93_010600	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FFF93_010605	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FFF93_010620	COG1113	amino acid transport
FFF93_010630	COG0022	dehydrogenase e1 component
FFF93_010635	COG0508	dehydrogenase complex catalyzes the overall conversion of
FFF93_010645	COG0477	Major facilitator Superfamily
FFF93_010660	COG1802	Transcriptional regulator
FFF93_010665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FFF93_010685	COG0419	ATPase involved in DNA repair
FFF93_010690	COG0420	3'-5' exonuclease activity
FFF93_010695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FFF93_010705	COG2149	membrane
FFF93_010725	COG0586	Pfam SNARE associated Golgi protein
FFF93_010730	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FFF93_010735	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FFF93_010740	COG1234	tRNA 3'-trailer cleavage
FFF93_010745	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FFF93_010750	COG2199	diguanylate cyclase activity
FFF93_010750	COG2203	Gaf domain
FFF93_010750	COG2200	EAL domain
FFF93_010760	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FFF93_010770	COG1335	isochorismatase
FFF93_010790	COG0363	glucosamine-6-phosphate deaminase activity
FFF93_010805	COG1902	pentaerythritol trinitrate reductase activity
FFF93_010835	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
FFF93_010840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FFF93_010850	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FFF93_010855	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FFF93_010865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FFF93_010870	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FFF93_010875	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FFF93_010880	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FFF93_010885	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FFF93_010890	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FFF93_010895	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FFF93_010900	COG0356	it plays a direct role in the translocation of protons across the membrane
FFF93_010920	COG1086	Polysaccharide biosynthesis protein
FFF93_010940	COG2890	protein-(glutamine-N5) methyltransferase activity
FFF93_010945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FFF93_010955	COG0083	homoserine kinase activity
FFF93_010960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FFF93_010965	COG0460	homoserine dehydrogenase
FFF93_010970	COG0019	diaminopimelate decarboxylase activity
FFF93_010975	COG0018	arginyl-trna synthetase
FFF93_010985	COG1335	isochorismatase
FFF93_011010	COG1643	Atp-dependent helicase
FFF93_011015	COG0537	adenosine 5'-monophosphoramidase activity
FFF93_011020	COG1064	alcohol dehydrogenase
FFF93_011055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FFF93_011060	COG1121	(ABC) transporter
FFF93_011085	COG0508	dehydrogenase complex catalyzes the overall conversion of
FFF93_011085	COG0567	Dehydrogenase, E1 component
FFF93_011110	COG1595	DNA-templated transcription, initiation
FFF93_011120	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FFF93_011130	COG0483	inositol monophosphate 1-phosphatase activity
FFF93_011135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FFF93_011155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FFF93_011160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FFF93_011180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FFF93_011185	COG0739	heme binding
FFF93_011195	COG2884	Cell division ATP-binding protein ftsE
FFF93_011200	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FFF93_011240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FFF93_011250	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FFF93_011250	COG5479	isomerase activity
FFF93_011265	COG0438	transferase activity, transferring glycosyl groups
FFF93_011295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FFF93_011295	COG2755	lipolytic protein G-D-S-L family
FFF93_011310	COG1216	Glycosyl transferase, family 2
FFF93_011320	COG1674	ftsk spoiiie
FFF93_011340	COG2902	Dehydrogenase
FFF93_011375	COG0653	protein targeting
FFF93_011380	COG3214	Protein conserved in bacteria
FFF93_011385	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FFF93_011395	COG5401	PFAM Sporulation and spore germination
FFF93_011425	COG0714	Associated with various cellular activities
FFF93_011450	COG4172	Belongs to the ABC transporter superfamily
FFF93_011455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FFF93_011460	COG0601	transmembrane transport
FFF93_011470	COG0482	sulfurtransferase activity
FFF93_011485	COG0697	spore germination
FFF93_011505	COG1597	lipid kinase activity
FFF93_011515	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FFF93_011520	COG1595	DNA-templated transcription, initiation
FFF93_011535	COG3265	gluconokinase activity
FFF93_011545	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FFF93_011555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FFF93_011565	COG1842	Phage shock protein A
FFF93_011570	COG0415	Belongs to the DNA photolyase family
FFF93_011595	COG1615	UPF0182 protein
FFF93_011600	COG0750	zinc metalloprotease
FFF93_011620	COG2816	NAD+ diphosphatase activity
FFF93_011660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FFF93_011665	COG2011	ABC-type metal ion transport system permease component
FFF93_011675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FFF93_011685	COG0113	porphobilinogen synthase activity
FFF93_011695	COG0181	hydroxymethylbilane synthase activity
FFF93_011720	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FFF93_011725	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FFF93_011760	COG4941	Belongs to the sigma-70 factor family
FFF93_011765	COG3795	YCII-related domain
FFF93_011780	COG2022	thiamine diphosphate biosynthetic process
FFF93_011790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FFF93_011795	COG0352	thiamine-phosphate diphosphorylase activity
FFF93_011805	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FFF93_011810	COG0513	Belongs to the DEAD box helicase family
FFF93_011815	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FFF93_011820	COG2095	MarC family integral membrane protein
FFF93_011830	COG0006	proline dipeptidase activity
FFF93_011840	COG2239	Acts as a magnesium transporter
FFF93_011855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FFF93_011865	COG1595	DNA-templated transcription, initiation
FFF93_011895	COG1126	abc transporter atp-binding protein
FFF93_011900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FFF93_011905	COG0765	amino acid transport
FFF93_011910	COG0765	amino acid transport
FFF93_011915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FFF93_011920	COG2171	N-acyltransferase activity
FFF93_011935	COG3226	Transcriptional regulator
FFF93_011995	COG4166	transmembrane transport
FFF93_012000	COG4172	Belongs to the ABC transporter superfamily
FFF93_012020	COG4166	transmembrane transport
FFF93_012105	COG1028	Short-chain dehydrogenase reductase Sdr
FFF93_012120	COG0028	Belongs to the TPP enzyme family
FFF93_012125	COG3387	PFAM Glycoside hydrolase 15-related
FFF93_012170	COG0583	DNA-binding transcription factor activity
FFF93_012180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FFF93_012190	COG0012	GTP binding
FFF93_012195	COG1322	Protein conserved in bacteria
FFF93_012200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FFF93_012210	COG1570	exodeoxyribonuclease VII activity
FFF93_012215	COG1722	exodeoxyribonuclease VII activity
FFF93_012220	COG2326	polyphosphate kinase activity
FFF93_012235	COG1174	glycine betaine transport
FFF93_012240	COG1174	glycine betaine transport
FFF93_012250	COG1162	GTPase activity
FFF93_012265	COG2971	BadF BadG BcrA BcrD
FFF93_012270	COG2070	2-Nitropropane dioxygenase
FFF93_012275	COG0583	DNA-binding transcription factor activity
FFF93_012280	COG2814	Major facilitator Superfamily
FFF93_012285	COG0626	cystathionine gamma-synthase activity
FFF93_012305	COG0598	Magnesium transport protein CorA
FFF93_012310	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FFF93_012320	COG0488	(ABC) transporter
FFF93_012330	COG3237	CsbD-like
FFF93_012335	COG1316	TRANSCRIPTIONal
FFF93_012365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FFF93_012370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FFF93_012390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FFF93_012390	COG0519	Catalyzes the synthesis of GMP from XMP
FFF93_012410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FFF93_012415	COG0516	GMP reductase activity
FFF93_012420	COG1404	Belongs to the peptidase S8 family
FFF93_012430	COG1132	(ABC) transporter
FFF93_012440	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FFF93_012440	COG2755	lipolytic protein G-D-S-L family
FFF93_012450	COG0459	protein refolding
FFF93_012455	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FFF93_012470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FFF93_012475	COG1472	Belongs to the glycosyl hydrolase 3 family
FFF93_012480	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FFF93_012485	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FFF93_012500	COG0802	atpase or kinase
FFF93_012505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FFF93_012515	COG1486	melibiose metabolic process
FFF93_012525	COG0438	transferase activity, transferring glycosyl groups
FFF93_012530	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FFF93_012545	COG0667	Aldo Keto reductase
FFF93_012570	COG0736	holo-[acyl-carrier-protein] synthase activity
FFF93_012575	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FFF93_012580	COG1072	(Pantothenic acid kinase))
FFF93_012585	COG1876	peptidase activity
FFF93_012600	COG1970	mechanosensitive ion channel activity
FFF93_012605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FFF93_012610	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FFF93_012615	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FFF93_012645	COG0455	bacterial-type flagellum organization
FFF93_012690	COG1192	Involved in chromosome partitioning
FFF93_012720	COG5002	protein histidine kinase activity
FFF93_012725	COG0101	tRNA pseudouridine synthase activity
FFF93_012730	COG0203	ribosomal protein L17
FFF93_012735	COG0202	RNA polymerase activity
FFF93_012740	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FFF93_012745	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FFF93_012750	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FFF93_012755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FFF93_012760	COG3191	aminopeptidase activity
FFF93_012765	COG1175	transmembrane transport
FFF93_012785	COG0563	adenylate kinase activity
FFF93_012795	COG0200	Binds to the 23S rRNA
FFF93_012800	COG1841	ribosomal large subunit assembly
FFF93_012805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FFF93_012815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FFF93_012820	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FFF93_012825	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FFF93_012830	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FFF93_012835	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FFF93_012850	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FFF93_012855	COG0255	Belongs to the universal ribosomal protein uL29 family
FFF93_012860	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FFF93_012865	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FFF93_012870	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FFF93_012875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FFF93_012880	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FFF93_012885	COG0089	rRNA binding
FFF93_012890	COG0088	Forms part of the polypeptide exit tunnel
FFF93_012895	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FFF93_012900	COG0051	transcription antitermination factor activity, RNA binding
FFF93_012910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FFF93_012915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FFF93_012920	COG0049	tRNA binding
FFF93_012925	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FFF93_012930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FFF93_012935	COG0085	RNA polymerase activity
FFF93_012940	COG0183	Belongs to the thiolase family
FFF93_012945	COG0442	prolyl-tRNA aminoacylation
FFF93_012950	COG0737	Belongs to the 5'-nucleotidase family
FFF93_012955	COG0222	ribosome binding
FFF93_012960	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FFF93_012975	COG0081	regulation of translation
FFF93_012980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FFF93_013000	COG0436	Aminotransferase
FFF93_013005	COG2197	response regulator
FFF93_013050	COG0354	folic acid binding
FFF93_013060	COG3485	protocatechuate 3,4-dioxygenase
FFF93_013070	COG0745	RESPONSE REGULATOR receiver
FFF93_013075	COG0456	acetyltransferase
FFF93_013080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FFF93_013090	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FFF93_013120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FFF93_013135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FFF93_013140	COG0738	Major facilitator superfamily
FFF93_013145	COG2030	dehydratase
FFF93_013150	COG2030	dehydratase
FFF93_013160	COG0659	secondary active sulfate transmembrane transporter activity
FFF93_013180	COG4989	oxidoreductase activity
FFF93_013185	COG0366	Alpha amylase catalytic
FFF93_013190	COG1940	carbohydrate kinase activity
FFF93_013195	COG0702	epimerase
FFF93_013200	COG2124	cytochrome p450
FFF93_013215	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FFF93_013230	COG0251	oxidation-reduction process
FFF93_013235	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FFF93_013240	COG0179	Fumarylacetoacetate (FAA) hydrolase
FFF93_013245	COG4608	Belongs to the ABC transporter superfamily
FFF93_013265	COG4166	transmembrane transport
FFF93_013270	COG1414	Transcriptional regulator
FFF93_013275	COG0673	inositol 2-dehydrogenase activity
FFF93_013315	COG5650	phosphatidylinositol metabolic process
FFF93_013325	COG1733	regulation of RNA biosynthetic process
FFF93_013330	COG1051	belongs to the nudix hydrolase family
FFF93_013345	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FFF93_013360	COG0318	PFAM AMP-dependent synthetase and ligase
FFF93_013370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FFF93_013385	COG0346	lactoylglutathione lyase activity
FFF93_013425	COG1666	GTP binding
FFF93_013430	COG0501	Belongs to the peptidase M48B family
FFF93_013455	COG1116	anion transmembrane transporter activity
FFF93_013460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FFF93_013465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FFF93_013470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FFF93_013500	COG0154	amidase activity
FFF93_013525	COG1012	belongs to the aldehyde dehydrogenase family
FFF93_013530	COG3835	regulator
FFF93_013560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FFF93_013560	COG1648	precorrin-2 dehydrogenase activity
FFF93_013580	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FFF93_013590	COG1690	Belongs to the RtcB family
FFF93_013605	COG0175	sulfate reduction
FFF93_013610	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FFF93_013620	COG2860	membrane
FFF93_013640	COG0644	oxidoreductase
FFF93_013645	COG2226	methyltransferase
FFF93_013650	COG1169	isochorismate synthase
FFF93_013660	COG0765	amino acid transport
FFF93_013675	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FFF93_013680	COG0018	arginyl-trna synthetase
FFF93_013690	COG4948	Mandelate Racemase Muconate Lactonizing
FFF93_013695	COG1621	beta-fructofuranosidase activity
FFF93_013725	COG0508	dehydrogenase complex catalyzes the overall conversion of
FFF93_013730	COG0022	dehydrogenase e1 component
FFF93_013745	COG4763	Acyl-transferase
FFF93_013750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FFF93_013755	COG1024	Enoyl-CoA hydratase
FFF93_013760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FFF93_013765	COG2151	metal-sulfur cluster biosynthetic enzyme
FFF93_013770	COG3396	Phenylacetate-CoA oxygenase
FFF93_013775	COG3460	Phenylacetate-CoA oxygenase
FFF93_013780	COG3396	Phenylacetate-CoA oxygenase
FFF93_013790	COG1316	TRANSCRIPTIONal
FFF93_013815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FFF93_013820	COG0280	phosphate acetyltransferase
FFF93_013820	COG0857	belongs to the CobB CobQ family
FFF93_013825	COG2050	protein possibly involved in aromatic compounds catabolism
FFF93_013855	COG1012	belongs to the aldehyde dehydrogenase family
FFF93_013855	COG2030	dehydratase
FFF93_013860	COG2050	protein possibly involved in aromatic compounds catabolism
FFF93_013875	COG1250	3-hydroxyacyl-CoA dehydrogenase
FFF93_013880	COG1024	Enoyl-CoA hydratase
FFF93_013885	COG0183	Belongs to the thiolase family
FFF93_013895	COG3237	CsbD-like
FFF93_013900	COG0412	Dienelactone hydrolase
FFF93_013910	COG1266	CAAX protease self-immunity
FFF93_013920	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FFF93_013950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FFF93_013960	COG0785	Cytochrome C biogenesis protein
FFF93_013965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FFF93_013970	COG0406	alpha-ribazole phosphatase activity
FFF93_013975	COG2353	YceI-like domain
FFF93_013990	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FFF93_014000	COG0560	Phosphoserine phosphatase
FFF93_014015	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FFF93_014025	COG0640	Transcriptional regulator
FFF93_014030	COG0123	including yeast histone deacetylase and acetoin utilization protein
FFF93_014035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FFF93_014040	COG0569	domain protein
FFF93_014045	COG0723	plastoquinol--plastocyanin reductase activity
FFF93_014045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FFF93_014060	COG3795	YCII-related domain
FFF93_014065	COG0248	Ppx GppA phosphatase
FFF93_014080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FFF93_014080	COG1754	DNA topoisomerase type I activity
FFF93_014085	COG0243	molybdopterin cofactor binding
FFF93_014110	COG2890	protein-(glutamine-N5) methyltransferase activity
FFF93_014115	COG0789	Transcriptional regulator
FFF93_014145	COG1205	dead DEAH box helicase
FFF93_014145	COG1111	helicase
FFF93_014195	COG0494	nUDIX hydrolase
FFF93_014200	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FFF93_014220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FFF93_014265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FFF93_014270	COG1408	metallophosphoesterase
FFF93_014275	COG1132	(ABC) transporter
FFF93_014280	COG1132	(ABC) transporter
FFF93_014300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FFF93_014305	COG0151	Belongs to the GarS family
FFF93_014325	COG1028	Short-chain dehydrogenase reductase Sdr
FFF93_014340	COG1921	L-seryl-tRNASec selenium transferase activity
FFF93_014350	COG0709	Synthesizes selenophosphate from selenide and ATP
FFF93_014360	COG0437	4 iron, 4 sulfur cluster binding
FFF93_014375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FFF93_014385	COG3387	PFAM Glycoside hydrolase 15-related
FFF93_014410	COG0484	heat shock protein binding
FFF93_014420	COG0789	Transcriptional regulator
FFF93_014440	COG4948	Mandelate Racemase Muconate Lactonizing
FFF93_014450	COG0800	Aldolase
FFF93_014455	COG4948	Mandelate Racemase Muconate Lactonizing
FFF93_014460	COG0395	ABC-type sugar transport system, permease component
FFF93_014465	COG1175	transmembrane transport
FFF93_014480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FFF93_014485	COG0589	response to stress
FFF93_014510	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FFF93_014540	COG0693	protein deglycase activity
FFF93_014550	COG1024	Enoyl-CoA hydratase
FFF93_014555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FFF93_014560	COG0477	Major facilitator Superfamily
FFF93_014565	COG3473	Maleate cis-trans isomerase
FFF93_014635	COG0318	PFAM AMP-dependent synthetase and ligase
FFF93_014640	COG1028	Short-chain dehydrogenase reductase Sdr
FFF93_014715	COG0363	glucosamine-6-phosphate deaminase activity
FFF93_014730	COG0165	Argininosuccinate lyase
FFF93_014735	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FFF93_014770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FFF93_014775	COG0800	Aldolase
FFF93_014780	COG1028	Short-chain dehydrogenase reductase Sdr
FFF93_014785	COG1063	alcohol dehydrogenase
FFF93_014790	COG1126	abc transporter atp-binding protein
FFF93_014795	COG0765	amino acid transport
FFF93_014815	COG1028	Short-chain dehydrogenase reductase Sdr
FFF93_014820	COG0179	Fumarylacetoacetate (FAA) hydrolase
FFF93_014835	COG4948	Mandelate Racemase Muconate Lactonizing
FFF93_014845	COG2271	Major facilitator Superfamily
FFF93_014865	COG0390	transport system, permease component
FFF93_014875	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FFF93_014885	COG1113	amino acid transport
FFF93_014890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FFF93_014895	COG1396	sequence-specific DNA binding
FFF93_014905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FFF93_014935	COG2271	Major facilitator Superfamily
FFF93_014940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FFF93_014945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FFF93_014960	COG2301	Belongs to the HpcH HpaI aldolase family
FFF93_014980	COG4867	von Willebrand factor, type A
FFF93_014985	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
FFF93_015015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FFF93_015020	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FFF93_015025	COG0277	FAD linked oxidase domain protein
FFF93_015040	COG0363	glucosamine-6-phosphate deaminase activity
FFF93_015045	COG1737	Transcriptional regulator
FFF93_015055	COG0601	transmembrane transport
FFF93_015065	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FFF93_015070	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FFF93_015095	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FFF93_015110	COG1840	ABC-type Fe3 transport system, periplasmic component
FFF93_015120	COG3842	ATPase activity
FFF93_015130	COG1802	Transcriptional regulator
FFF93_015140	COG0431	NADPH-dependent FMN reductase
FFF93_015140	COG1053	succinate dehydrogenase
FFF93_015140	COG3976	FMN-binding domain protein
FFF93_015185	COG2267	carboxylic ester hydrolase activity
FFF93_015210	COG3622	Belongs to the hyi family
FFF93_015225	COG2226	methyltransferase
FFF93_015240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FFF93_015270	COG0542	response to heat
FFF93_015290	COG3246	L-lysine catabolic process to acetate
FFF93_015295	COG1929	Belongs to the glycerate kinase type-1 family
FFF93_015300	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FFF93_015325	COG3585	molybdate ion transport
FFF93_015360	COG2353	YceI-like domain
FFF93_015375	COG0463	Glycosyl transferase, family 2
FFF93_015410	COG0135	phosphoribosylanthranilate isomerase activity
FFF93_015420	COG2076	Multidrug Resistance protein
FFF93_015430	COG0667	Aldo Keto reductase
FFF93_015455	COG1473	amidohydrolase
FFF93_015460	COG0477	Major facilitator Superfamily
FFF93_015465	COG2807	transmembrane transport
FFF93_015470	COG4106	trans-aconitate 2-methyltransferase activity
FFF93_015475	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FFF93_015510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FFF93_015520	COG0789	Transcriptional regulator
FFF93_015525	COG0484	heat shock protein binding
FFF93_015530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FFF93_015535	COG0443	Heat shock 70 kDa protein
FFF93_015555	COG2409	Drug exporters of the RND superfamily
FFF93_015585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FFF93_015590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FFF93_015600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FFF93_015620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FFF93_015650	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FFF93_015655	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FFF93_015665	COG1122	ATPase activity
FFF93_015670	COG4721	ABC-type cobalt transport system, permease component
FFF93_015675	COG4702	Belongs to the UPF0303 family
FFF93_015685	COG1320	monovalent cation:proton antiporter activity
FFF93_015690	COG2212	antiporter activity
FFF93_015695	COG1863	multisubunit Na H antiporter MnhE subunit
FFF93_015710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FFF93_015710	COG2111	Na H antiporter
FFF93_015725	COG0475	glutathione-regulated potassium exporter activity
FFF93_015730	COG0717	Belongs to the dCTP deaminase family
FFF93_015740	COG2814	Major facilitator Superfamily
FFF93_015765	COG1946	Acyl-CoA thioesterase
FFF93_015775	COG0179	Fumarylacetoacetate (FAA) hydrolase
FFF93_015780	COG0251	oxidation-reduction process
FFF93_015805	COG2814	Major facilitator Superfamily
FFF93_015820	COG0583	DNA-binding transcription factor activity
FFF93_015830	COG1012	belongs to the aldehyde dehydrogenase family
FFF93_015835	COG0531	amino acid
FFF93_015845	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FFF93_015865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FFF93_015870	COG0667	Aldo Keto reductase
FFF93_015880	COG0433	COG0433 Predicted ATPase
FFF93_015900	COG3336	cytochrome c oxidase
FFF93_015905	COG0776	regulation of translation
FFF93_015925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FFF93_015945	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FFF93_015950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FFF93_015955	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FFF93_015960	COG1017	nitric oxide dioxygenase activity
FFF93_015960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FFF93_016040	COG3012	SEC-C Motif Domain Protein
FFF93_016050	COG0667	Aldo Keto reductase
FFF93_016075	COG1028	Short-chain dehydrogenase reductase Sdr
FFF93_016100	COG1228	amidohydrolase
FFF93_016110	COG3395	kinase activity
FFF93_016115	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FFF93_016120	COG1349	DNA-binding transcription factor activity
FFF93_016150	COG0039	L-malate dehydrogenase activity
FFF93_016160	COG0640	Transcriptional regulator
FFF93_016175	COG2186	Transcriptional regulator
FFF93_016185	COG1027	Aspartate ammonia-lyase
FFF93_016205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FFF93_016215	COG1522	sequence-specific DNA binding
FFF93_016220	COG1280	lysine exporter protein (LysE YggA)
FFF93_016240	COG1309	transcriptional regulator
FFF93_016250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FFF93_016255	COG0477	Major facilitator Superfamily
FFF93_016260	COG0477	Major facilitator Superfamily
FFF93_016265	COG2814	Major facilitator Superfamily
FFF93_016280	COG1113	amino acid transport
FFF93_016285	COG0246	Mannitol dehydrogenase
FFF93_016290	COG2213	PTS system mannitol-specific
FFF93_016290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FFF93_016300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FFF93_016320	COG0686	Belongs to the AlaDH PNT family
FFF93_016325	COG0673	inositol 2-dehydrogenase activity
FFF93_016360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FFF93_016370	COG0318	PFAM AMP-dependent synthetase and ligase
FFF93_016380	COG0508	dehydrogenase complex catalyzes the overall conversion of
FFF93_016385	COG0022	dehydrogenase e1 component
FFF93_016395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FFF93_016400	COG1950	PFAM Membrane protein of
FFF93_016415	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FFF93_016440	COG1840	ABC-type Fe3 transport system, periplasmic component
FFF93_016445	COG3842	ATPase activity
FFF93_016450	COG1178	ABC-type Fe3 transport system permease component
FFF93_016465	COG1414	Transcriptional regulator
FFF93_016475	COG1970	mechanosensitive ion channel activity
FFF93_016485	COG1597	lipid kinase activity
FFF93_016500	COG1414	Transcriptional regulator
FFF93_016505	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FFF93_016515	COG0183	Belongs to the thiolase family
FFF93_016520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FFF93_016530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FFF93_016535	COG3485	protocatechuate 3,4-dioxygenase
FFF93_016540	COG3485	protocatechuate 3,4-dioxygenase
FFF93_016545	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FFF93_016550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FFF93_016555	COG1414	Transcriptional regulator
FFF93_016565	COG1793	dna ligase
FFF93_016600	COG1937	Protein conserved in bacteria
FFF93_016645	COG2259	Doxx family
FFF93_016650	COG1607	acyl-coa hydrolase
FFF93_016655	COG0305	Participates in initiation and elongation during chromosome replication
FFF93_016680	COG0359	binds to the 23S rRNA
FFF93_016685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FFF93_016695	COG0360	Binds together with S18 to 16S ribosomal RNA
FFF93_016705	COG1362	aminopeptidase activity
FFF93_016740	COG0738	Major facilitator superfamily
FFF93_016745	COG0488	(ABC) transporter
FFF93_016755	COG2197	response regulator
FFF93_016770	COG1136	(ABC) transporter
FFF93_016785	COG0406	alpha-ribazole phosphatase activity
FFF93_016790	COG0617	tRNA 3'-terminal CCA addition
FFF93_016820	COG0492	ferredoxin-NADP+ reductase activity
FFF93_016825	COG3118	belongs to the thioredoxin family
FFF93_016835	COG1192	Involved in chromosome partitioning
FFF93_016840	COG0357	Ribosomal RNA small subunit methyltransferase G
FFF93_016850	COG0706	membrane insertase activity
FFF93_016855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FFF93_016860	COG0594	ribonuclease P activity
FFF93_016865	COG0230	Belongs to the bacterial ribosomal protein bL34 family