locus-tag	class	description
AFL94_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFL94_00010	COG0592	DNA-directed DNA polymerase activity
AFL94_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AFL94_00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AFL94_00025	COG0187	DNA topoisomerase II activity
AFL94_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AFL94_00035	COG3266	domain, Protein
AFL94_00060	COG0385	Bile acid
AFL94_00075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AFL94_00090	COG0583	DNA-binding transcription factor activity
AFL94_00095	COG2076	Multidrug Resistance protein
AFL94_00105	COG3764	Sortase (surface protein transpeptidase)
AFL94_00120	COG0515	serine threonine protein kinase
AFL94_00120	COG2815	serine threonine protein kinase
AFL94_00125	COG0515	serine threonine protein kinase
AFL94_00145	COG1716	ATPase activity
AFL94_00170	COG1609	Transcriptional regulator
AFL94_00175	COG1957	nucleoside hydrolase
AFL94_00180	COG0412	Dienelactone hydrolase
AFL94_00195	COG1024	Enoyl-CoA hydratase
AFL94_00205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFL94_00210	COG0561	phosphatase activity
AFL94_00230	COG0477	Major facilitator Superfamily
AFL94_00235	COG2233	PERMEase
AFL94_00240	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AFL94_00240	COG0351	phosphomethylpyrimidine kinase
AFL94_00240	COG0352	thiamine-phosphate diphosphorylase activity
AFL94_00245	COG0352	thiamine-phosphate diphosphorylase activity
AFL94_00250	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AFL94_00265	COG1012	belongs to the aldehyde dehydrogenase family
AFL94_00270	COG0833	amino acid
AFL94_00275	COG0033	Phosphoglucomutase
AFL94_00290	COG3655	Transcriptional regulator
AFL94_00295	COG3104	oligopeptide transport
AFL94_00300	COG0154	amidase activity
AFL94_00320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AFL94_00325	COG0561	phosphatase activity
AFL94_00355	COG1322	Protein conserved in bacteria
AFL94_00365	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AFL94_00370	COG2027	D-alanyl-D-alanine carboxypeptidase
AFL94_00380	COG0037	tRNA processing
AFL94_00390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFL94_00395	COG0302	gtp cyclohydrolase
AFL94_00405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AFL94_00430	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AFL94_00455	COG1476	TRANSCRIPTIONal
AFL94_00485	COG3590	peptidase
AFL94_00490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AFL94_00500	COG0542	response to heat
AFL94_00520	COG4977	sequence-specific DNA binding
AFL94_00530	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AFL94_00540	COG1194	a g-specific adenine glycosylase
AFL94_00550	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AFL94_00555	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AFL94_00565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AFL94_00580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AFL94_00595	COG0306	phosphate transporter
AFL94_00645	COG0488	(ABC) transporter
AFL94_00650	COG2226	methyltransferase
AFL94_00685	COG0596	Alpha beta hydrolase
AFL94_00695	COG0824	Thioesterase
AFL94_00710	COG1937	Protein conserved in bacteria
AFL94_00715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFL94_00730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFL94_00750	COG0277	FAD linked oxidase domain protein
AFL94_00875	COG2252	PERMEase
AFL94_00925	COG1024	Enoyl-CoA hydratase
AFL94_00940	COG1960	acyl-CoA dehydrogenase activity
AFL94_00965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AFL94_00975	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AFL94_00990	COG1129	ABC transporter
AFL94_00990	COG0842	Transport permease protein
AFL94_01005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFL94_01005	COG0357	Ribosomal RNA small subunit methyltransferase G
AFL94_01025	COG0515	serine threonine protein kinase
AFL94_01080	COG0745	RESPONSE REGULATOR receiver
AFL94_01085	COG5002	protein histidine kinase activity
AFL94_01095	COG1522	sequence-specific DNA binding
AFL94_01105	COG1113	amino acid transport
AFL94_01130	COG0004	ammonium transporteR
AFL94_01135	COG0347	Belongs to the P(II) protein family
AFL94_01150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFL94_01160	COG0583	DNA-binding transcription factor activity
AFL94_01170	COG0697	spore germination
AFL94_01185	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AFL94_01195	COG0028	Belongs to the TPP enzyme family
AFL94_01200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFL94_01220	COG0726	polysaccharide deacetylase
AFL94_01235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFL94_01240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFL94_01240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AFL94_01240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AFL94_01245	COG1105	Belongs to the carbohydrate kinase PfkB family
AFL94_01250	COG1349	DNA-binding transcription factor activity
AFL94_01260	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFL94_01265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFL94_01270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFL94_01275	COG1832	CoA-binding protein
AFL94_01285	COG0406	alpha-ribazole phosphatase activity
AFL94_01295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFL94_01295	COG2169	Transcriptional regulator
AFL94_01300	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AFL94_01310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AFL94_01315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFL94_01320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFL94_01350	COG0405	Gamma-glutamyltransferase
AFL94_01370	COG0702	epimerase
AFL94_01380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFL94_01385	COG2011	ABC-type metal ion transport system permease component
AFL94_01390	COG1464	Belongs to the NlpA lipoprotein family
AFL94_01395	COG1960	acyl-CoA dehydrogenase activity
AFL94_01405	COG1832	CoA-binding protein
AFL94_01410	COG2315	Protein conserved in bacteria
AFL94_01425	COG0737	Belongs to the 5'-nucleotidase family
AFL94_01450	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_01465	COG2824	Alkylphosphonate utilization operon protein PhnA
AFL94_01480	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFL94_01485	COG0047	phosphoribosylformylglycinamidine synthase activity
AFL94_01490	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFL94_01495	COG3012	SEC-C Motif Domain Protein
AFL94_01505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AFL94_01525	COG2318	DinB family
AFL94_01530	COG2851	Citrate transporter
AFL94_01535	COG3290	protein histidine kinase activity
AFL94_01540	COG4565	transcriptional regulatory protein
AFL94_01585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFL94_01640	COG0406	alpha-ribazole phosphatase activity
AFL94_01660	COG2814	Major facilitator Superfamily
AFL94_01675	COG1476	TRANSCRIPTIONal
AFL94_01685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFL94_01690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AFL94_01695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFL94_01705	COG0531	amino acid
AFL94_01720	COG1414	Transcriptional regulator
AFL94_01755	COG0542	response to heat
AFL94_01760	COG2197	response regulator
AFL94_01765	COG4585	Histidine kinase
AFL94_01770	COG0778	Nitroreductase
AFL94_01800	COG1472	Belongs to the glycosyl hydrolase 3 family
AFL94_01815	COG0351	phosphomethylpyrimidine kinase
AFL94_01835	COG4133	protoheme IX ABC transporter activity
AFL94_01845	COG0343	queuine tRNA-ribosyltransferase activity
AFL94_01860	COG2814	Major facilitator Superfamily
AFL94_01875	COG0564	pseudouridine synthase activity
AFL94_01880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFL94_01885	COG1201	RNA secondary structure unwinding
AFL94_01890	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AFL94_01910	COG0786	glutamate:sodium symporter activity
AFL94_01915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFL94_01955	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFL94_01970	COG3485	protocatechuate 3,4-dioxygenase
AFL94_01975	COG3485	protocatechuate 3,4-dioxygenase
AFL94_01985	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AFL94_01995	COG2814	Major facilitator Superfamily
AFL94_02000	COG0183	Belongs to the thiolase family
AFL94_02010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AFL94_02015	COG1414	Transcriptional regulator
AFL94_02040	COG0584	glycerophosphoryl diester phosphodiesterase
AFL94_02045	COG0521	Mo-molybdopterin cofactor biosynthetic process
AFL94_02045	COG0315	cyclic pyranopterin monophosphate synthase activity
AFL94_02050	COG0315	cyclic pyranopterin monophosphate synthase activity
AFL94_02080	COG2318	DinB family
AFL94_02090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AFL94_02115	COG0746	molybdenum cofactor guanylyltransferase activity
AFL94_02140	COG1140	nitrate reductase beta subunit
AFL94_02180	COG0590	tRNA wobble adenosine to inosine editing
AFL94_02185	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AFL94_02190	COG2205	protein histidine kinase activity
AFL94_02195	COG0745	RESPONSE REGULATOR receiver
AFL94_02225	COG1511	domain protein
AFL94_02280	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AFL94_02285	COG2814	Major facilitator Superfamily
AFL94_02300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFL94_02300	COG1017	nitric oxide dioxygenase activity
AFL94_02305	COG1959	2 iron, 2 sulfur cluster binding
AFL94_02320	COG0514	ATP-dependent DNA helicase (RecQ)
AFL94_02335	COG1505	serine-type exopeptidase activity
AFL94_02350	COG0604	alcohol dehydrogenase
AFL94_02355	COG1966	Carbon starvation protein
AFL94_02370	COG0656	L-ascorbic acid biosynthetic process
AFL94_02400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AFL94_02415	COG0588	phosphoglycerate mutase activity
AFL94_02430	COG5002	protein histidine kinase activity
AFL94_02445	COG1329	Transcriptional regulator
AFL94_02450	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AFL94_02450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AFL94_02455	COG0215	cysteine-tRNA ligase activity
AFL94_02460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFL94_02480	COG0277	FAD linked oxidase domain protein
AFL94_02520	COG3842	ATPase activity
AFL94_02550	COG2801	Transposase and inactivated derivatives
AFL94_02570	COG2354	Protein conserved in bacteria
AFL94_02605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AFL94_02620	COG0459	protein refolding
AFL94_02640	COG2205	protein histidine kinase activity
AFL94_02645	COG0745	RESPONSE REGULATOR receiver
AFL94_02655	COG1278	Cold shock
AFL94_02670	COG1321	iron dependent repressor
AFL94_02675	COG0739	heme binding
AFL94_02715	COG0045	succinate-CoA ligase (ADP-forming) activity
AFL94_02755	COG1396	sequence-specific DNA binding
AFL94_02785	COG0028	Belongs to the TPP enzyme family
AFL94_02805	COG2814	Major facilitator Superfamily
AFL94_02820	COG2508	Transcriptional regulator
AFL94_02825	COG1960	acyl-CoA dehydrogenase activity
AFL94_02830	COG1012	belongs to the aldehyde dehydrogenase family
AFL94_02835	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFL94_02860	COG0519	Catalyzes the synthesis of GMP from XMP
AFL94_02875	COG0577	efflux transmembrane transporter activity
AFL94_02875	COG1136	(ABC) transporter
AFL94_02880	COG0577	efflux transmembrane transporter activity
AFL94_02925	COG1295	ribonuclease BN
AFL94_02930	COG3583	domain protein
AFL94_02935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFL94_02945	COG3483	tryptophan 2,3-dioxygenase activity
AFL94_02955	COG3971	2-oxopent-4-enoate hydratase activity
AFL94_03010	COG0477	Major facilitator Superfamily
AFL94_03020	COG0138	bifunctional purine biosynthesis protein purh
AFL94_03025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AFL94_03045	COG1914	H( )-stimulated, divalent metal cation uptake system
AFL94_03050	COG4336	lyase activity
AFL94_03080	COG4770	biotin carboxylase activity
AFL94_03085	COG1984	allophanate hydrolase subunit 2
AFL94_03090	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AFL94_03100	COG2814	Major facilitator Superfamily
AFL94_03110	COG2838	Isocitrate dehydrogenase
AFL94_03120	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AFL94_03125	COG1802	Transcriptional regulator
AFL94_03135	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_03170	COG1136	(ABC) transporter
AFL94_03245	COG3708	Transcriptional regulator
AFL94_03245	COG2207	Transcriptional regulator
AFL94_03250	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AFL94_03265	COG2072	flavoprotein involved in K transport
AFL94_03270	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AFL94_03300	COG2261	transglycosylase associated protein
AFL94_03305	COG0477	Major facilitator Superfamily
AFL94_03310	COG0583	DNA-binding transcription factor activity
AFL94_03320	COG2197	response regulator
AFL94_03345	COG0708	Exodeoxyribonuclease III
AFL94_03350	COG0180	Tryptophanyl-tRNA synthetase
AFL94_03355	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AFL94_03370	COG0659	secondary active sulfate transmembrane transporter activity
AFL94_03380	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AFL94_03385	COG2197	response regulator
AFL94_03410	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AFL94_03415	COG1053	succinate dehydrogenase
AFL94_03425	COG2009	succinate dehydrogenase
AFL94_03430	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AFL94_03430	COG0662	Cupin 2, conserved barrel domain protein
AFL94_03435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AFL94_03440	COG1473	amidohydrolase
AFL94_03440	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AFL94_03445	COG1744	ABC transporter substrate-binding protein PnrA-like
AFL94_03480	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AFL94_03495	COG0148	phosphopyruvate hydratase activity
AFL94_03545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AFL94_03550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AFL94_03560	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AFL94_03575	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AFL94_03580	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AFL94_03600	COG0477	Major facilitator Superfamily
AFL94_03625	COG0114	fumarate hydratase activity
AFL94_03640	COG1494	fructose-1,6-bisphosphatase
AFL94_03650	COG1316	TRANSCRIPTIONal
AFL94_03655	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AFL94_03715	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
AFL94_03740	COG0714	Associated with various cellular activities
AFL94_03745	COG0084	hydrolase, TatD family'
AFL94_03750	COG3583	domain protein
AFL94_03755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFL94_03760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AFL94_03790	COG0488	(ABC) transporter
AFL94_03800	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AFL94_03815	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AFL94_03820	COG0193	aminoacyl-tRNA hydrolase activity
AFL94_03835	COG0822	iron-sulfur transferase activity
AFL94_03840	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AFL94_03875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFL94_03890	COG0477	Major facilitator Superfamily
AFL94_03910	COG4770	biotin carboxylase activity
AFL94_03920	COG0754	glutathionylspermidine amidase activity
AFL94_03930	COG0424	maF-like protein
AFL94_03935	COG2409	Drug exporters of the RND superfamily
AFL94_03955	COG0640	Transcriptional regulator
AFL94_03960	COG0346	lactoylglutathione lyase activity
AFL94_03970	COG2814	Major facilitator Superfamily
AFL94_03985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFL94_03990	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_03990	COG3347	Dehydrogenase
AFL94_04015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AFL94_04040	COG0363	glucosamine-6-phosphate deaminase activity
AFL94_04045	COG1472	Belongs to the glycosyl hydrolase 3 family
AFL94_04075	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFL94_04080	COG0154	amidase activity
AFL94_04085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFL94_04105	COG0747	negative chemotaxis
AFL94_04110	COG0601	transmembrane transport
AFL94_04120	COG0444	Belongs to the ABC transporter superfamily
AFL94_04125	COG4608	Belongs to the ABC transporter superfamily
AFL94_04135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFL94_04145	COG0477	Major facilitator Superfamily
AFL94_04155	COG1063	alcohol dehydrogenase
AFL94_04165	COG1609	Transcriptional regulator
AFL94_04170	COG1653	transport
AFL94_04175	COG1175	transmembrane transport
AFL94_04180	COG0395	ABC-type sugar transport system, permease component
AFL94_04195	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AFL94_04205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFL94_04210	COG1228	amidohydrolase
AFL94_04215	COG1228	amidohydrolase
AFL94_04220	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AFL94_04230	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AFL94_04235	COG1105	Belongs to the carbohydrate kinase PfkB family
AFL94_04265	COG1349	DNA-binding transcription factor activity
AFL94_04295	COG2873	o-acetylhomoserine
AFL94_04300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFL94_04305	COG2755	lipolytic protein G-D-S-L family
AFL94_04320	COG2501	S4 domain
AFL94_04325	COG0423	glycine-tRNA ligase activity
AFL94_04370	COG0358	DNA primase activity
AFL94_04405	COG1695	Transcriptional regulator
AFL94_04420	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AFL94_04435	COG0438	transferase activity, transferring glycosyl groups
AFL94_04455	COG0438	transferase activity, transferring glycosyl groups
AFL94_04470	COG0052	Belongs to the universal ribosomal protein uS2 family
AFL94_04475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AFL94_04480	COG0528	UMP kinase activity
AFL94_04485	COG0233	cytoplasmic translational termination
AFL94_04490	COG0575	Belongs to the CDS family
AFL94_04500	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFL94_04510	COG3279	Response regulator of the LytR AlgR family
AFL94_04515	COG3275	phosphorelay sensor kinase activity
AFL94_04525	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFL94_04530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AFL94_04535	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFL94_04540	COG1215	transferase activity, transferring glycosyl groups
AFL94_04555	COG0022	dehydrogenase e1 component
AFL94_04560	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFL94_04565	COG0747	negative chemotaxis
AFL94_04570	COG0601	transmembrane transport
AFL94_04575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFL94_04595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFL94_04615	COG1960	acyl-CoA dehydrogenase activity
AFL94_04620	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AFL94_04625	COG0750	zinc metalloprotease
AFL94_04645	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AFL94_04675	COG0442	prolyl-tRNA aminoacylation
AFL94_04685	COG2197	response regulator
AFL94_04690	COG4585	Histidine kinase
AFL94_04715	COG0779	Required for maturation of 30S ribosomal subunits
AFL94_04725	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AFL94_04725	COG0481	GTPase activity
AFL94_04730	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AFL94_04760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFL94_04770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFL94_04785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AFL94_04800	COG0196	riboflavin kinase activity
AFL94_04810	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AFL94_04830	COG1619	proteins homologs of microcin C7 resistance protein MccF
AFL94_04860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFL94_04865	COG0318	PFAM AMP-dependent synthetase and ligase
AFL94_04870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFL94_04880	COG0589	response to stress
AFL94_04900	COG3290	protein histidine kinase activity
AFL94_04905	COG4565	transcriptional regulatory protein
AFL94_04915	COG2807	transmembrane transport
AFL94_04920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFL94_04925	COG1185	polyribonucleotide nucleotidyltransferase activity
AFL94_04955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AFL94_04985	COG0028	Belongs to the TPP enzyme family
AFL94_05025	COG0251	oxidation-reduction process
AFL94_05035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFL94_05040	COG1854	S-ribosylhomocysteine lyase activity
AFL94_05055	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AFL94_05060	COG1053	succinate dehydrogenase
AFL94_05065	COG0583	DNA-binding transcription factor activity
AFL94_05070	COG0477	Major facilitator Superfamily
AFL94_05075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFL94_05100	COG1063	alcohol dehydrogenase
AFL94_05120	COG0612	Peptidase, M16
AFL94_05135	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AFL94_05150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFL94_05155	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AFL94_05170	COG2314	TM2 domain
AFL94_05180	COG1174	glycine betaine transport
AFL94_05195	COG1674	ftsk spoiiie
AFL94_05205	COG1058	Belongs to the CinA family
AFL94_05205	COG1546	Belongs to the CinA family
AFL94_05220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AFL94_05230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFL94_05235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AFL94_05240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AFL94_05245	COG2813	Specifically methylates the guanine in position
AFL94_05260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AFL94_05270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFL94_05275	COG0131	Imidazoleglycerol-phosphate dehydratase
AFL94_05280	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AFL94_05285	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AFL94_05305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AFL94_05310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AFL94_05315	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AFL94_05320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFL94_05325	COG0494	nUDIX hydrolase
AFL94_05335	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AFL94_05340	COG0072	phenylalanine-tRNA ligase activity
AFL94_05340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFL94_05345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFL94_05360	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AFL94_05395	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AFL94_05400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AFL94_05405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFL94_05410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFL94_05415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AFL94_05420	COG1438	arginine binding
AFL94_05430	COG0165	Argininosuccinate lyase
AFL94_05440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AFL94_05450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AFL94_05480	COG0647	UMP catabolic process
AFL94_05495	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFL94_05500	COG0497	DNA recombination
AFL94_05505	COG0504	CTP synthase activity
AFL94_05510	COG0494	nUDIX hydrolase
AFL94_05515	COG4974	Belongs to the 'phage' integrase family
AFL94_05520	COG0494	nUDIX hydrolase
AFL94_05525	COG3655	Transcriptional regulator
AFL94_05540	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AFL94_05545	COG2079	MmgE PrpD family protein
AFL94_05570	COG3290	protein histidine kinase activity
AFL94_05575	COG1301	dicarboxylic acid transport
AFL94_05595	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AFL94_05610	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AFL94_05615	COG1160	GTP binding
AFL94_05625	COG0384	phenazine biosynthesis protein PhzF
AFL94_05635	COG0488	(ABC) transporter
AFL94_05645	COG3189	MarR family transcriptional regulator
AFL94_05650	COG1716	ATPase activity
AFL94_05670	COG1192	Involved in chromosome partitioning
AFL94_05675	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AFL94_05685	COG1022	Amp-dependent synthetase and ligase
AFL94_05705	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AFL94_05765	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AFL94_05770	COG2884	Cell division ATP-binding protein ftsE
AFL94_05775	COG2177	Part of the ABC transporter FtsEX involved in
AFL94_05780	COG0741	lytic transglycosylase activity
AFL94_05780	COG1196	nuclear chromosome segregation
AFL94_05780	COG0739	heme binding
AFL94_05785	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AFL94_05795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFL94_05800	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFL94_05805	COG0589	response to stress
AFL94_05810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFL94_05810	COG1321	iron dependent repressor
AFL94_05815	COG0483	inositol monophosphate 1-phosphatase activity
AFL94_05825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AFL94_05830	COG1595	DNA-templated transcription, initiation
AFL94_05845	COG0567	Dehydrogenase, E1 component
AFL94_05845	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFL94_05850	COG1253	flavin adenine dinucleotide binding
AFL94_05855	COG1253	flavin adenine dinucleotide binding
AFL94_05860	COG1121	(ABC) transporter
AFL94_05885	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AFL94_05895	COG0537	adenosine 5'-monophosphoramidase activity
AFL94_05900	COG1643	Atp-dependent helicase
AFL94_05915	COG1116	anion transmembrane transporter activity
AFL94_05915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFL94_05925	COG0018	arginyl-trna synthetase
AFL94_05930	COG0019	diaminopimelate decarboxylase activity
AFL94_05935	COG0460	homoserine dehydrogenase
AFL94_05940	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFL94_05945	COG0083	homoserine kinase activity
AFL94_05955	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AFL94_05965	COG0009	L-threonylcarbamoyladenylate synthase
AFL94_05970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFL94_05980	COG0356	it plays a direct role in the translocation of protons across the membrane
AFL94_05985	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFL94_05990	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AFL94_05995	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFL94_06000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AFL94_06005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AFL94_06010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AFL94_06015	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AFL94_06030	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AFL94_06080	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AFL94_06080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AFL94_06095	COG1335	isochorismatase
AFL94_06100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AFL94_06105	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AFL94_06115	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AFL94_06120	COG1234	tRNA 3'-trailer cleavage
AFL94_06135	COG0302	gtp cyclohydrolase
AFL94_06150	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AFL94_06155	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AFL94_06165	COG1131	(ABC) transporter
AFL94_06175	COG2176	DNA-directed DNA polymerase activity
AFL94_06190	COG0420	3'-5' exonuclease activity
AFL94_06195	COG0419	ATPase involved in DNA repair
AFL94_06215	COG1609	Transcriptional regulator
AFL94_06220	COG0366	Alpha amylase catalytic
AFL94_06230	COG1175	transmembrane transport
AFL94_06235	COG3833	ABC-type maltose transport systems, permease component
AFL94_06250	COG0477	Major facilitator Superfamily
AFL94_06275	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AFL94_06275	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AFL94_06290	COG1335	isochorismatase
AFL94_06295	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AFL94_06300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AFL94_06310	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AFL94_06315	COG1234	tRNA 3'-trailer cleavage
AFL94_06330	COG0302	gtp cyclohydrolase
AFL94_06345	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AFL94_06350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AFL94_06360	COG1131	(ABC) transporter
AFL94_06370	COG2176	DNA-directed DNA polymerase activity
AFL94_06385	COG0420	3'-5' exonuclease activity
AFL94_06390	COG0419	ATPase involved in DNA repair
AFL94_06410	COG1609	Transcriptional regulator
AFL94_06415	COG0366	Alpha amylase catalytic
AFL94_06425	COG1175	transmembrane transport
AFL94_06430	COG3833	ABC-type maltose transport systems, permease component
AFL94_06445	COG0477	Major facilitator Superfamily
AFL94_06460	COG0488	(ABC) transporter
AFL94_06470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFL94_06485	COG1012	belongs to the aldehyde dehydrogenase family
AFL94_06490	COG1802	Transcriptional regulator
AFL94_06510	COG0129	dihydroxy-acid dehydratase activity
AFL94_06535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AFL94_06585	COG1846	Transcriptional regulator
AFL94_06595	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AFL94_06600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFL94_06605	COG1256	bacterial-type flagellum assembly
AFL94_06615	COG1191	sigma factor activity
AFL94_06620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFL94_06625	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AFL94_06640	COG1815	bacterial-type flagellum-dependent cell motility
AFL94_06645	COG1558	bacterial-type flagellum-dependent cell motility
AFL94_06655	COG1766	The M ring may be actively involved in energy transduction
AFL94_06670	COG1157	protein secretion by the type III secretion system
AFL94_06680	COG0791	NLP P60 protein
AFL94_06705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AFL94_06730	COG1338	Plays a role in the flagellum-specific transport system
AFL94_06735	COG1987	bacterial-type flagellum assembly
AFL94_06745	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFL94_06750	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFL94_06760	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AFL94_06780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFL94_06795	COG0579	oxidoreductase
AFL94_06805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFL94_06840	COG1846	Transcriptional regulator
AFL94_06845	COG0702	epimerase
AFL94_06890	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AFL94_06915	COG1215	transferase activity, transferring glycosyl groups
AFL94_06925	COG0129	dihydroxy-acid dehydratase activity
AFL94_06930	COG0028	Belongs to the TPP enzyme family
AFL94_06935	COG0440	acetolactate synthase activity
AFL94_06940	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AFL94_06955	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AFL94_06960	COG1088	dTDP-glucose 4,6-dehydratase activity
AFL94_06975	COG2197	response regulator
AFL94_06985	COG0673	inositol 2-dehydrogenase activity
AFL94_06990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFL94_06995	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AFL94_07190	COG1432	Conserved Protein
AFL94_07200	COG2197	response regulator
AFL94_07205	COG4585	Histidine kinase
AFL94_07210	COG0473	3-isopropylmalate dehydrogenase activity
AFL94_07215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AFL94_07220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AFL94_07225	COG0179	Fumarylacetoacetate (FAA) hydrolase
AFL94_07230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFL94_07235	COG0546	phosphoglycolate phosphatase activity
AFL94_07255	COG1162	GTPase activity
AFL94_07265	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AFL94_07275	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AFL94_07280	COG0066	3-isopropylmalate dehydratase activity
AFL94_07285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AFL94_07295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AFL94_07300	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFL94_07310	COG1316	TRANSCRIPTIONal
AFL94_07315	COG1461	Dihydroxyacetone kinase
AFL94_07325	COG0742	ribosomal rna small subunit methyltransferase
AFL94_07340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AFL94_07345	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AFL94_07350	COG1316	TRANSCRIPTIONal
AFL94_07365	COG1215	transferase activity, transferring glycosyl groups
AFL94_07375	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AFL94_07385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AFL94_07385	COG1215	transferase activity, transferring glycosyl groups
AFL94_07395	COG2801	Transposase and inactivated derivatives
AFL94_07405	COG0438	transferase activity, transferring glycosyl groups
AFL94_07425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFL94_07435	COG1196	nuclear chromosome segregation
AFL94_07450	COG2755	lipolytic protein G-D-S-L family
AFL94_07450	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AFL94_07480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFL94_07485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFL94_07490	COG2514	catechol 2,3-dioxygenase activity
AFL94_07525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFL94_07530	COG0183	Belongs to the thiolase family
AFL94_07535	COG2837	iron assimilation
AFL94_07585	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AFL94_07615	COG1960	acyl-CoA dehydrogenase activity
AFL94_07620	COG0242	peptide deformylase activity
AFL94_07665	COG3022	response to hydroperoxide
AFL94_07670	COG0346	lactoylglutathione lyase activity
AFL94_07675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AFL94_07680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFL94_07690	COG1045	serine acetyltransferase
AFL94_07700	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AFL94_07715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AFL94_07720	COG2130	NADP-dependent
AFL94_07740	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AFL94_07750	COG2610	gluconate transmembrane transporter activity
AFL94_07755	COG3265	gluconokinase activity
AFL94_07760	COG2261	transglycosylase associated protein
AFL94_07770	COG1272	protein, Hemolysin III
AFL94_07775	COG3237	CsbD-like
AFL94_07810	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AFL94_07825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFL94_07850	COG4974	Belongs to the 'phage' integrase family
AFL94_07860	COG0606	chelatase, subunit chli
AFL94_07865	COG0792	nuclease activity
AFL94_07875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AFL94_07880	COG0681	Belongs to the peptidase S26 family
AFL94_07890	COG0681	Belongs to the peptidase S26 family
AFL94_07895	COG0335	large ribosomal subunit rRNA binding
AFL94_07900	COG0336	Belongs to the RNA methyltransferase TrmD family
AFL94_07905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AFL94_07910	COG1837	Belongs to the UPF0109 family
AFL94_07915	COG0228	four-way junction DNA binding
AFL94_07920	COG1280	lysine exporter protein (LysE YggA)
AFL94_07960	COG0488	(ABC) transporter
AFL94_07985	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_07990	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_08020	COG1119	ATPase activity
AFL94_08035	COG0254	rRNA binding
AFL94_08040	COG0604	alcohol dehydrogenase
AFL94_08045	COG0095	Lipoate-protein ligase
AFL94_08110	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_08120	COG0438	transferase activity, transferring glycosyl groups
AFL94_08135	COG1053	succinate dehydrogenase
AFL94_08135	COG3976	FMN-binding domain protein
AFL94_08145	COG1914	H( )-stimulated, divalent metal cation uptake system
AFL94_08150	COG0745	RESPONSE REGULATOR receiver
AFL94_08155	COG2205	protein histidine kinase activity
AFL94_08165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFL94_08185	COG1968	undecaprenyl-diphosphatase activity
AFL94_08190	COG0215	cysteine-tRNA ligase activity
AFL94_08200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFL94_08205	COG0517	IMP dehydrogenase activity
AFL94_08205	COG1994	Peptidase M50
AFL94_08215	COG1222	aaa ATPase
AFL94_08220	COG4122	O-methyltransferase activity
AFL94_08230	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AFL94_08235	COG0545	Peptidyl-prolyl cis-trans isomerase
AFL94_08255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFL94_08260	COG0805	protein transport
AFL94_08275	COG1216	Glycosyl transferase, family 2
AFL94_08295	COG2226	methyltransferase
AFL94_08300	COG0242	peptide deformylase activity
AFL94_08320	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AFL94_08350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFL94_08355	COG1845	cytochrome c oxidase, subunit III
AFL94_08360	COG2010	Cytochrome c
AFL94_08365	COG0723	plastoquinol--plastocyanin reductase activity
AFL94_08370	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AFL94_08390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AFL94_08395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AFL94_08415	COG0167	dihydroorotate dehydrogenase activity
AFL94_08420	COG2267	carboxylic ester hydrolase activity
AFL94_08425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AFL94_08430	COG1381	Involved in DNA repair and RecF pathway recombination
AFL94_08435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFL94_08445	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AFL94_08455	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AFL94_08470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AFL94_08475	COG0484	heat shock protein binding
AFL94_08480	COG1420	regulation of RNA biosynthetic process
AFL94_08500	COG0481	GTPase activity
AFL94_08510	COG0268	Binds directly to 16S ribosomal RNA
AFL94_08520	COG2333	competence protein COMEC
AFL94_08520	COG0658	competence protein
AFL94_08530	COG1307	EDD domain protein, DegV family
AFL94_08535	COG0495	leucyl-tRNA aminoacylation
AFL94_08550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AFL94_08555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AFL94_08565	COG2390	Transcriptional regulator
AFL94_08585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AFL94_08595	COG1758	RNA polymerase activity
AFL94_08600	COG0194	GDP metabolic process
AFL94_08610	COG0284	orotidine-5'-phosphate decarboxylase activity
AFL94_08615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AFL94_08620	COG0505	Belongs to the CarA family
AFL94_08630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AFL94_08635	COG0540	Belongs to the ATCase OTCase family
AFL94_08640	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AFL94_08645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AFL94_08650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AFL94_08660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AFL94_08665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AFL94_08670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AFL94_08675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFL94_08685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AFL94_08690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AFL94_08985	COG4974	Belongs to the 'phage' integrase family
AFL94_08990	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AFL94_09000	COG1490	D-aminoacyl-tRNA deacylase activity
AFL94_09015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AFL94_09020	COG0124	histidyl-tRNA synthetase
AFL94_09025	COG1196	nuclear chromosome segregation
AFL94_09035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFL94_09040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFL94_09050	COG1862	Preprotein translocase
AFL94_09055	COG2255	four-way junction helicase activity
AFL94_09060	COG0632	four-way junction helicase activity
AFL94_09065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AFL94_09070	COG0217	transcriptional regulatory protein
AFL94_09075	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AFL94_09085	COG0339	signal peptide processing
AFL94_09090	COG0456	acetyltransferase
AFL94_09105	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AFL94_09110	COG0584	glycerophosphoryl diester phosphodiesterase
AFL94_09115	COG1653	transport
AFL94_09120	COG0395	ABC-type sugar transport system, permease component
AFL94_09130	COG1349	DNA-binding transcription factor activity
AFL94_09135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFL94_09145	COG1131	(ABC) transporter
AFL94_09160	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AFL94_09170	COG0156	8-amino-7-oxononanoate synthase activity
AFL94_09175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFL94_09180	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AFL94_09190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AFL94_09220	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AFL94_09225	COG0587	DNA-directed DNA polymerase activity
AFL94_09240	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_09245	COG0477	Major facilitator Superfamily
AFL94_09250	COG0656	L-ascorbic acid biosynthetic process
AFL94_09260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFL94_09270	COG2135	peptidase activity
AFL94_09310	COG2814	Major facilitator Superfamily
AFL94_09320	COG3848	Pyruvate phosphate dikinase
AFL94_09320	COG0574	Belongs to the PEP-utilizing enzyme family
AFL94_09325	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFL94_09330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFL94_09335	COG1780	Probably involved in ribonucleotide reductase function
AFL94_09345	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AFL94_09350	COG0028	Belongs to the TPP enzyme family
AFL94_09355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AFL94_09365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AFL94_09380	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFL94_09410	COG0488	(ABC) transporter
AFL94_09420	COG1053	succinate dehydrogenase
AFL94_09425	COG0583	DNA-binding transcription factor activity
AFL94_09440	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_09450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFL94_09455	COG1113	amino acid transport
AFL94_09475	COG0598	Magnesium transport protein CorA
AFL94_09520	COG0799	negative regulation of ribosome biogenesis
AFL94_09530	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AFL94_09540	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AFL94_09545	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFL94_09550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFL94_09555	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AFL94_09560	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AFL94_09565	COG1530	ribonuclease E activity
AFL94_09600	COG0105	UTP biosynthetic process
AFL94_09610	COG0285	dihydrofolate synthase activity
AFL94_09615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AFL94_09630	COG4585	Histidine kinase
AFL94_09635	COG2197	response regulator
AFL94_09640	COG2409	Drug exporters of the RND superfamily
AFL94_09650	COG1846	Transcriptional regulator
AFL94_09655	COG1764	response to oxidative stress
AFL94_09715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFL94_09740	COG0525	valine-tRNA ligase activity
AFL94_09750	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AFL94_09755	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AFL94_09760	COG0740	serine-type endopeptidase activity
AFL94_09770	COG0544	peptidyl-prolyl cis-trans isomerase activity
AFL94_09795	COG0698	ribose 5-phosphate isomerase
AFL94_09820	COG1946	Acyl-CoA thioesterase
AFL94_09865	COG1522	sequence-specific DNA binding
AFL94_09870	COG1280	lysine exporter protein (LysE YggA)
AFL94_09875	COG1122	ATPase activity
AFL94_09880	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AFL94_09885	COG1268	BioY protein
AFL94_09890	COG0318	PFAM AMP-dependent synthetase and ligase
AFL94_09900	COG2151	metal-sulfur cluster biosynthetic enzyme
AFL94_09905	COG2151	metal-sulfur cluster biosynthetic enzyme
AFL94_09910	COG0396	ATPase activity
AFL94_09930	COG1131	(ABC) transporter
AFL94_09955	COG0109	protoheme IX farnesyltransferase activity
AFL94_09965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AFL94_09985	COG0363	glucosamine-6-phosphate deaminase activity
AFL94_10005	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFL94_10010	COG0149	triose-phosphate isomerase activity
AFL94_10015	COG0126	phosphoglycerate kinase activity
AFL94_10030	COG1481	regulation of sporulation
AFL94_10035	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AFL94_10040	COG1660	Displays ATPase and GTPase activities
AFL94_10045	COG0322	excinuclease ABC activity
AFL94_10055	COG0546	phosphoglycolate phosphatase activity
AFL94_10090	COG4106	trans-aconitate 2-methyltransferase activity
AFL94_10150	COG1846	Transcriptional regulator
AFL94_10155	COG0861	Integral membrane protein TerC family
AFL94_10160	COG0556	nucleotide-excision repair
AFL94_10185	COG0237	dephospho-CoA kinase activity
AFL94_10195	COG1739	Uncharacterized protein family UPF0029
AFL94_10220	COG0539	negative regulation of cytoplasmic translation
AFL94_10240	COG2050	protein possibly involved in aromatic compounds catabolism
AFL94_10270	COG0469	pyruvate kinase activity
AFL94_10280	COG0070	glutamate synthase
AFL94_10280	COG0069	glutamate synthase activity
AFL94_10280	COG0067	glutamate synthase
AFL94_10285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AFL94_10290	COG0159	tryptophan synthase activity
AFL94_10295	COG0133	tryptophan synthase activity
AFL94_10300	COG0134	indole-3-glycerol-phosphate synthase activity
AFL94_10320	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AFL94_10330	COG0107	imidazoleglycerol-phosphate synthase activity
AFL94_10335	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AFL94_10340	COG0140	phosphoribosyl-ATP diphosphatase activity
AFL94_10345	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AFL94_10350	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFL94_10350	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFL94_10370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AFL94_10380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AFL94_10385	COG0242	peptide deformylase activity
AFL94_10440	COG3135	benzoate transporter
AFL94_10445	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFL94_10460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AFL94_10470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFL94_10500	COG0183	Belongs to the thiolase family
AFL94_10505	COG1024	Enoyl-CoA hydratase
AFL94_10505	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFL94_10520	COG0667	Aldo Keto reductase
AFL94_10525	COG0137	argininosuccinate synthase activity
AFL94_10550	COG3557	Belongs to the UPF0374 family
AFL94_10555	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AFL94_10600	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AFL94_10610	COG0531	amino acid
AFL94_10615	COG0569	domain protein
AFL94_10640	COG0756	dUTP diphosphatase activity
AFL94_10670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFL94_10670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFL94_10675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AFL94_10680	COG4988	ABC transporter
AFL94_10685	COG1294	oxidase, subunit
AFL94_10690	COG1271	oxidase subunit
AFL94_10705	COG0187	DNA topoisomerase II activity
AFL94_10715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AFL94_10735	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AFL94_10740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFL94_10745	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFL94_10760	COG0321	lipoyl(octanoyl) transferase activity
AFL94_10765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AFL94_10780	COG0174	glutamine synthetase
AFL94_10790	COG0590	tRNA wobble adenosine to inosine editing
AFL94_10800	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AFL94_10805	COG0174	glutamine synthetase
AFL94_10810	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AFL94_10825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AFL94_10830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AFL94_10835	COG0587	DNA-directed DNA polymerase activity
AFL94_10845	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AFL94_10860	COG1799	cell septum assembly
AFL94_10870	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AFL94_10875	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AFL94_10880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFL94_10885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFL94_10890	COG0772	Belongs to the SEDS family
AFL94_10895	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AFL94_10900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFL94_10925	COG0275	rRNA processing
AFL94_10930	COG2001	Belongs to the MraZ family
AFL94_10965	COG2902	Dehydrogenase
AFL94_10995	COG0653	protein targeting
AFL94_11000	COG3214	Protein conserved in bacteria
AFL94_11005	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AFL94_11010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AFL94_11015	COG5401	PFAM Sporulation and spore germination
AFL94_11020	COG5002	protein histidine kinase activity
AFL94_11025	COG0745	RESPONSE REGULATOR receiver
AFL94_11040	COG4172	Belongs to the ABC transporter superfamily
AFL94_11045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFL94_11050	COG0601	transmembrane transport
AFL94_11055	COG4533	DNA binding
AFL94_11075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFL94_11105	COG0482	sulfurtransferase activity
AFL94_11120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AFL94_11135	COG0484	heat shock protein binding
AFL94_11140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AFL94_11155	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFL94_11165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFL94_11175	COG1842	Phage shock protein A
AFL94_11195	COG1615	UPF0182 protein
AFL94_11200	COG3480	Lon protease (S16) C-terminal proteolytic domain
AFL94_11250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFL94_11255	COG2011	ABC-type metal ion transport system permease component
AFL94_11260	COG1464	Belongs to the NlpA lipoprotein family
AFL94_11265	COG0531	amino acid
AFL94_11270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFL94_11275	COG0113	porphobilinogen synthase activity
AFL94_11285	COG0181	hydroxymethylbilane synthase activity
AFL94_11305	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AFL94_11310	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AFL94_11315	COG1309	transcriptional regulator
AFL94_11335	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AFL94_11345	COG0006	proline dipeptidase activity
AFL94_11355	COG2239	Acts as a magnesium transporter
AFL94_11365	COG0489	protein tyrosine kinase activity
AFL94_11365	COG2151	metal-sulfur cluster biosynthetic enzyme
AFL94_11375	COG1595	DNA-templated transcription, initiation
AFL94_11390	COG1611	Belongs to the LOG family
AFL94_11395	COG1126	abc transporter atp-binding protein
AFL94_11400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFL94_11405	COG0765	amino acid transport
AFL94_11410	COG0765	amino acid transport
AFL94_11415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFL94_11420	COG2171	N-acyltransferase activity
AFL94_11450	COG1819	glycosyl
AFL94_11480	COG2022	thiamine diphosphate biosynthetic process
AFL94_11510	COG0596	Alpha beta hydrolase
AFL94_11560	COG0798	PFAM Bile acid sodium symporter
AFL94_11620	COG4044	May play a role in the intracellular transport of hydrophobic ligands
AFL94_11680	COG0012	GTP binding
AFL94_11685	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AFL94_11690	COG1570	exodeoxyribonuclease VII activity
AFL94_11695	COG1722	exodeoxyribonuclease VII activity
AFL94_11705	COG2326	polyphosphate kinase activity
AFL94_11730	COG1522	sequence-specific DNA binding
AFL94_11740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFL94_11745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AFL94_11765	COG0519	Catalyzes the synthesis of GMP from XMP
AFL94_11765	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFL94_11780	COG0516	GMP reductase activity
AFL94_11810	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AFL94_11810	COG2755	lipolytic protein G-D-S-L family
AFL94_11825	COG0459	protein refolding
AFL94_11830	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AFL94_11835	COG0833	amino acid
AFL94_11850	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AFL94_11855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AFL94_11860	COG0456	acetyltransferase
AFL94_11865	COG0456	acetyltransferase
AFL94_11865	COG1214	PFAM Peptidase M22, glycoprotease
AFL94_11870	COG0802	atpase or kinase
AFL94_11875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AFL94_11880	COG1970	mechanosensitive ion channel activity
AFL94_11885	COG1072	(Pantothenic acid kinase))
AFL94_11890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AFL94_11895	COG0736	holo-[acyl-carrier-protein] synthase activity
AFL94_11900	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AFL94_11900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AFL94_11925	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFL94_11930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFL94_11935	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AFL94_11940	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AFL94_11945	COG0101	tRNA pseudouridine synthase activity
AFL94_11955	COG0203	ribosomal protein L17
AFL94_11960	COG0202	RNA polymerase activity
AFL94_11965	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AFL94_11970	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFL94_11975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AFL94_11985	COG0563	adenylate kinase activity
AFL94_11995	COG0200	Binds to the 23S rRNA
AFL94_12000	COG1841	ribosomal large subunit assembly
AFL94_12005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AFL94_12010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AFL94_12015	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AFL94_12020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AFL94_12025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AFL94_12030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AFL94_12035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AFL94_12060	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AFL94_12070	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AFL94_12075	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AFL94_12080	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AFL94_12085	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AFL94_12090	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AFL94_12095	COG0089	rRNA binding
AFL94_12100	COG0088	Forms part of the polypeptide exit tunnel
AFL94_12105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AFL94_12110	COG0051	transcription antitermination factor activity, RNA binding
AFL94_12120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFL94_12125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AFL94_12130	COG0049	tRNA binding
AFL94_12135	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AFL94_12145	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AFL94_12150	COG0085	RNA polymerase activity
AFL94_12160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AFL94_12165	COG0222	ribosome binding
AFL94_12170	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AFL94_12175	COG0081	regulation of translation
AFL94_12180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AFL94_12185	COG0250	Participates in transcription elongation, termination and antitermination
AFL94_12190	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFL94_12200	COG0436	Aminotransferase
AFL94_12240	COG3485	protocatechuate 3,4-dioxygenase
AFL94_12250	COG0745	RESPONSE REGULATOR receiver
AFL94_12255	COG0456	acetyltransferase
AFL94_12260	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AFL94_12275	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AFL94_12290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AFL94_12295	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AFL94_12300	COG0738	Major facilitator superfamily
AFL94_12310	COG2030	dehydratase
AFL94_12335	COG2357	RelA SpoT domain protein
AFL94_12380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFL94_12390	COG1666	GTP binding
AFL94_12395	COG0501	Belongs to the peptidase M48B family
AFL94_12410	COG0733	neurotransmitter:sodium symporter activity
AFL94_12445	COG0765	amino acid transport
AFL94_12450	COG1126	abc transporter atp-binding protein
AFL94_12455	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AFL94_12465	COG4948	Mandelate Racemase Muconate Lactonizing
AFL94_12480	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFL94_12485	COG0022	dehydrogenase e1 component
AFL94_12495	COG1522	sequence-specific DNA binding
AFL94_12500	COG1024	Enoyl-CoA hydratase
AFL94_12505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFL94_12510	COG2151	metal-sulfur cluster biosynthetic enzyme
AFL94_12515	COG3396	Phenylacetate-CoA oxygenase
AFL94_12520	COG3460	Phenylacetate-CoA oxygenase
AFL94_12525	COG3396	Phenylacetate-CoA oxygenase
AFL94_12530	COG2259	Doxx family
AFL94_12535	COG1126	abc transporter atp-binding protein
AFL94_12540	COG0765	amino acid transport
AFL94_12550	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AFL94_12555	COG2050	protein possibly involved in aromatic compounds catabolism
AFL94_12575	COG2030	dehydratase
AFL94_12575	COG1012	belongs to the aldehyde dehydrogenase family
AFL94_12580	COG2050	protein possibly involved in aromatic compounds catabolism
AFL94_12610	COG1584	GPR1 FUN34 yaaH family protein
AFL94_12620	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFL94_12625	COG1024	Enoyl-CoA hydratase
AFL94_12635	COG0477	Major facilitator Superfamily
AFL94_12640	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AFL94_12665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFL94_12675	COG0785	Cytochrome C biogenesis protein
AFL94_12680	COG3118	belongs to the thioredoxin family
AFL94_12685	COG0406	alpha-ribazole phosphatase activity
AFL94_12695	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AFL94_12705	COG0560	Phosphoserine phosphatase
AFL94_12715	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AFL94_12720	COG0640	Transcriptional regulator
AFL94_12725	COG0123	including yeast histone deacetylase and acetoin utilization protein
AFL94_12730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AFL94_12735	COG0569	domain protein
AFL94_12750	COG1082	Xylose isomerase domain protein TIM barrel
AFL94_12755	COG0248	Ppx GppA phosphatase
AFL94_12760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFL94_12760	COG1754	DNA topoisomerase type I activity
AFL94_12790	COG1205	dead DEAH box helicase
AFL94_12790	COG1111	helicase
AFL94_12835	COG0494	nUDIX hydrolase
AFL94_12845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFL94_12855	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AFL94_12860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFL94_12875	COG0251	oxidation-reduction process
AFL94_12880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AFL94_12890	COG1132	(ABC) transporter
AFL94_12895	COG1132	(ABC) transporter
AFL94_12900	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AFL94_12905	COG0151	Belongs to the GarS family
AFL94_12930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AFL94_12945	COG3547	Transposase (IS116 IS110 IS902 family)
AFL94_12955	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AFL94_12975	COG0861	Integral membrane protein TerC family
AFL94_12980	COG3304	Inner membrane component domain
AFL94_12985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AFL94_12995	COG0789	Transcriptional regulator
AFL94_13000	COG0484	heat shock protein binding
AFL94_13005	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AFL94_13010	COG0443	Heat shock 70 kDa protein
AFL94_13030	COG2409	Drug exporters of the RND superfamily
AFL94_13035	COG1846	Transcriptional regulator
AFL94_13040	COG1280	lysine exporter protein (LysE YggA)
AFL94_13060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFL94_13070	COG1122	ATPase activity
AFL94_13075	COG4721	ABC-type cobalt transport system, permease component
AFL94_13085	COG1320	monovalent cation:proton antiporter activity
AFL94_13095	COG1863	multisubunit Na H antiporter MnhE subunit
AFL94_13110	COG2111	Na H antiporter
AFL94_13110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFL94_13120	COG0717	Belongs to the dCTP deaminase family
AFL94_13135	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AFL94_13135	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AFL94_13155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFL94_13160	COG0765	amino acid transport
AFL94_13165	COG1126	abc transporter atp-binding protein
AFL94_13170	COG0433	COG0433 Predicted ATPase
AFL94_13180	COG2814	Major facilitator Superfamily
AFL94_13205	COG2847	Copper chaperone PCu(A)C
AFL94_13220	COG0776	regulation of translation
AFL94_13225	COG0776	regulation of translation
AFL94_13230	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_13240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AFL94_13245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFL94_13250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AFL94_13265	COG1176	ABC-type spermidine putrescine transport system, permease component I
AFL94_13270	COG3842	ATPase activity
AFL94_13285	COG1522	sequence-specific DNA binding
AFL94_13290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFL94_13340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFL94_13405	COG3226	Transcriptional regulator
AFL94_13420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFL94_13460	COG2239	Acts as a magnesium transporter
AFL94_13470	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFL94_13475	COG0509	glycine decarboxylation via glycine cleavage system
AFL94_13480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AFL94_13485	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFL94_13485	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFL94_13500	COG0531	amino acid
AFL94_13515	COG0435	Glutathione S-transferase
AFL94_13530	COG1132	(ABC) transporter
AFL94_13540	COG1120	ATPase activity
AFL94_13545	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFL94_13550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFL94_13555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFL94_13570	COG1136	(ABC) transporter
AFL94_13615	COG1309	transcriptional regulator
AFL94_13620	COG1960	acyl-CoA dehydrogenase activity
AFL94_13625	COG1643	Atp-dependent helicase
AFL94_13630	COG2267	carboxylic ester hydrolase activity
AFL94_13635	COG0667	Aldo Keto reductase
AFL94_13640	COG1012	belongs to the aldehyde dehydrogenase family
AFL94_13660	COG2197	response regulator
AFL94_13670	COG1528	Iron-storage protein
AFL94_13690	COG4946	Tricorn protease homolog
AFL94_13690	COG0823	Involved in the tonB-independent uptake of proteins
AFL94_13690	COG1506	peptidase
AFL94_13700	COG2860	membrane
AFL94_13715	COG0477	Major facilitator Superfamily
AFL94_13720	COG1278	Cold shock
AFL94_13725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFL94_13750	COG0583	DNA-binding transcription factor activity
AFL94_13760	COG0069	glutamate synthase activity
AFL94_13765	COG1132	(ABC) transporter
AFL94_13770	COG4988	ABC transporter
AFL94_13780	COG0135	phosphoribosylanthranilate isomerase activity
AFL94_13790	COG4585	Histidine kinase
AFL94_13795	COG2197	response regulator
AFL94_13800	COG4152	abc transporter atp-binding protein
AFL94_13820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFL94_13830	COG0789	Transcriptional regulator
AFL94_13855	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFL94_13885	COG1473	amidohydrolase
AFL94_13890	COG0561	phosphatase activity
AFL94_13930	COG3191	aminopeptidase activity
AFL94_13945	COG1404	Belongs to the peptidase S8 family
AFL94_13955	COG1063	alcohol dehydrogenase
AFL94_13960	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_13980	COG2814	Major facilitator Superfamily
AFL94_13990	COG3145	DNA-N1-methyladenine dioxygenase activity
AFL94_13995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFL94_14010	COG0783	Belongs to the Dps family
AFL94_14025	COG2986	histidine ammonia-lyase
AFL94_14030	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AFL94_14050	COG1869	D-ribose catabolic process
AFL94_14055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFL94_14060	COG1879	ABC-type sugar transport system periplasmic component
AFL94_14065	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFL94_14070	COG1129	ABC transporter
AFL94_14080	COG1321	iron dependent repressor
AFL94_14085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFL94_14090	COG2188	Transcriptional regulator
AFL94_14110	COG3639	organic phosphonate transmembrane transporter activity
AFL94_14115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFL94_14120	COG1121	(ABC) transporter
AFL94_14150	COG0789	Transcriptional regulator
AFL94_14210	COG0569	domain protein
AFL94_14215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AFL94_14225	COG1522	sequence-specific DNA binding
AFL94_14235	COG2211	Major facilitator Superfamily
AFL94_14245	COG2146	nitrite reductase [NAD(P)H] activity
AFL94_14280	COG2188	Transcriptional regulator
AFL94_14285	COG1620	l-lactate permease
AFL94_14290	COG0247	lactate metabolic process
AFL94_14295	COG1139	Iron-sulfur cluster binding protein
AFL94_14300	COG1556	Lactate utilization protein
AFL94_14325	COG1174	glycine betaine transport
AFL94_14335	COG1174	glycine betaine transport
AFL94_14340	COG0179	Fumarylacetoacetate (FAA) hydrolase
AFL94_14345	COG1115	amino acid carrier protein
AFL94_14350	COG2301	Belongs to the HpcH HpaI aldolase family
AFL94_14355	COG1113	amino acid transport
AFL94_14380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFL94_14390	COG2050	protein possibly involved in aromatic compounds catabolism
AFL94_14395	COG1414	Transcriptional regulator
AFL94_14400	COG1082	Xylose isomerase domain protein TIM barrel
AFL94_14405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFL94_14410	COG0477	Major facilitator Superfamily
AFL94_14415	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_14425	COG0583	DNA-binding transcription factor activity
AFL94_14435	COG0583	DNA-binding transcription factor activity
AFL94_14440	COG2855	membrane
AFL94_14455	COG1960	acyl-CoA dehydrogenase activity
AFL94_14460	COG2149	membrane
AFL94_14475	COG0477	Major facilitator Superfamily
AFL94_14485	COG1733	regulation of RNA biosynthetic process
AFL94_14525	COG0318	PFAM AMP-dependent synthetase and ligase
AFL94_14540	COG2814	Major facilitator Superfamily
AFL94_14595	COG1414	Transcriptional regulator
AFL94_14615	COG0183	Belongs to the thiolase family
AFL94_14620	COG0588	phosphoglycerate mutase activity
AFL94_14625	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AFL94_14630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFL94_14635	COG0028	Belongs to the TPP enzyme family
AFL94_14650	COG2186	Transcriptional regulator
AFL94_14660	COG1027	Aspartate ammonia-lyase
AFL94_14670	COG0823	Involved in the tonB-independent uptake of proteins
AFL94_14670	COG1506	peptidase
AFL94_14695	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFL94_14700	COG0022	dehydrogenase e1 component
AFL94_14710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFL94_14715	COG1950	PFAM Membrane protein of
AFL94_14730	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFL94_14735	COG2223	nitrite transmembrane transporter activity
AFL94_14740	COG0243	molybdopterin cofactor binding
AFL94_14745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFL94_14755	COG2146	nitrite reductase [NAD(P)H] activity
AFL94_14755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFL94_14760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AFL94_14760	COG1648	precorrin-2 dehydrogenase activity
AFL94_14770	COG0667	Aldo Keto reductase
AFL94_14780	COG0277	FAD linked oxidase domain protein
AFL94_14800	COG2233	PERMEase
AFL94_14810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AFL94_14825	COG0318	PFAM AMP-dependent synthetase and ligase
AFL94_14840	COG2197	response regulator
AFL94_14845	COG4585	Histidine kinase
AFL94_14855	COG1131	(ABC) transporter
AFL94_14875	COG0006	proline dipeptidase activity
AFL94_14880	COG1228	amidohydrolase
AFL94_14900	COG0436	Aminotransferase
AFL94_14905	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFL94_14920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AFL94_14925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFL94_14930	COG2226	methyltransferase
AFL94_14970	COG2957	Belongs to the agmatine deiminase family
AFL94_14975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFL94_15015	COG2066	Belongs to the glutaminase family
AFL94_15020	COG1607	acyl-coa hydrolase
AFL94_15045	COG3850	Histidine kinase
AFL94_15065	COG1842	Phage shock protein A
AFL94_15110	COG2807	transmembrane transport
AFL94_15135	COG1937	Protein conserved in bacteria
AFL94_15150	COG1289	transmembrane transporter activity
AFL94_15160	COG1113	amino acid transport
AFL94_15170	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AFL94_15175	COG0531	amino acid
AFL94_15180	COG2154	pterin-4-alpha-carbinolamine dehydratase
AFL94_15200	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AFL94_15205	COG0531	amino acid
AFL94_15225	COG0477	Major facilitator Superfamily
AFL94_15235	COG0534	Mate efflux family protein
AFL94_15245	COG2814	Major facilitator Superfamily
AFL94_15250	COG1266	CAAX protease self-immunity
AFL94_15260	COG0747	negative chemotaxis
AFL94_15265	COG0601	transmembrane transport
AFL94_15270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFL94_15280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AFL94_15295	COG0583	DNA-binding transcription factor activity
AFL94_15305	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFL94_15345	COG1960	acyl-CoA dehydrogenase activity
AFL94_15350	COG1960	acyl-CoA dehydrogenase activity
AFL94_15395	COG1012	belongs to the aldehyde dehydrogenase family
AFL94_15415	COG1309	transcriptional regulator
AFL94_15420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFL94_15420	COG1042	CoA-binding domain protein
AFL94_15420	COG0045	succinate-CoA ligase (ADP-forming) activity
AFL94_15425	COG1960	acyl-CoA dehydrogenase activity
AFL94_15455	COG0501	Belongs to the peptidase M48B family
AFL94_15465	COG0583	DNA-binding transcription factor activity
AFL94_15470	COG0477	Major facilitator Superfamily
AFL94_15475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFL94_15480	COG0154	amidase activity
AFL94_15495	COG2154	pterin-4-alpha-carbinolamine dehydratase
AFL94_15505	COG2323	membrane
AFL94_15510	COG0531	amino acid
AFL94_15520	COG1335	isochorismatase
AFL94_15540	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_15555	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AFL94_15560	COG3285	dna ligase
AFL94_15560	COG1793	dna ligase
AFL94_15570	COG1012	belongs to the aldehyde dehydrogenase family
AFL94_15580	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AFL94_15595	COG0415	Belongs to the DNA photolyase family
AFL94_15620	COG1012	belongs to the aldehyde dehydrogenase family
AFL94_15625	COG0028	Belongs to the TPP enzyme family
AFL94_15640	COG0477	Major facilitator Superfamily
AFL94_15650	COG2508	Transcriptional regulator
AFL94_15740	COG1122	ATPase activity
AFL94_15770	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AFL94_15790	COG1414	Transcriptional regulator
AFL94_15800	COG0574	Belongs to the PEP-utilizing enzyme family
AFL94_15800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFL94_15805	COG3848	Pyruvate phosphate dikinase
AFL94_15805	COG0574	Belongs to the PEP-utilizing enzyme family
AFL94_15810	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_15835	COG2066	Belongs to the glutaminase family
AFL94_15875	COG2755	lipolytic protein G-D-S-L family
AFL94_15875	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AFL94_15885	COG0745	RESPONSE REGULATOR receiver
AFL94_15890	COG2205	protein histidine kinase activity
AFL94_15905	COG2855	membrane
AFL94_15925	COG1295	ribonuclease BN
AFL94_15935	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AFL94_15940	COG3960	tartronate-semialdehyde synthase activity
AFL94_15945	COG2084	Dehydrogenase
AFL94_15950	COG3622	Belongs to the hyi family
AFL94_15955	COG1953	Uracil, thiamine, allantoin
AFL94_15980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFL94_15985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFL94_16020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFL94_16035	COG0738	Major facilitator superfamily
AFL94_16045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFL94_16095	COG2267	carboxylic ester hydrolase activity
AFL94_16100	COG1929	Belongs to the glycerate kinase type-1 family
AFL94_16115	COG0659	secondary active sulfate transmembrane transporter activity
AFL94_16125	COG2199	diguanylate cyclase activity
AFL94_16125	COG2200	EAL domain
AFL94_16125	COG2203	Gaf domain
AFL94_16140	COG0318	PFAM AMP-dependent synthetase and ligase
AFL94_16210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AFL94_16220	COG0477	Major facilitator Superfamily
AFL94_16230	COG1414	Transcriptional regulator
AFL94_16240	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AFL94_16245	COG1940	carbohydrate kinase activity
AFL94_16250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFL94_16255	COG4608	Belongs to the ABC transporter superfamily
AFL94_16260	COG0444	Belongs to the ABC transporter superfamily
AFL94_16265	COG0601	transmembrane transport
AFL94_16270	COG0747	negative chemotaxis
AFL94_16275	COG2186	Transcriptional regulator
AFL94_16285	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFL94_16305	COG1414	Transcriptional regulator
AFL94_16320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFL94_16350	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFL94_16365	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_16370	COG1024	Enoyl-CoA hydratase
AFL94_16405	COG0477	Major facilitator Superfamily
AFL94_16410	COG0183	Belongs to the thiolase family
AFL94_16420	COG1960	acyl-CoA dehydrogenase activity
AFL94_16425	COG1024	Enoyl-CoA hydratase
AFL94_16430	COG1960	acyl-CoA dehydrogenase activity
AFL94_16435	COG1960	acyl-CoA dehydrogenase activity
AFL94_16440	COG1960	acyl-CoA dehydrogenase activity
AFL94_16465	COG0183	Belongs to the thiolase family
AFL94_16485	COG1902	pentaerythritol trinitrate reductase activity
AFL94_16530	COG1733	regulation of RNA biosynthetic process
AFL94_16570	COG1196	nuclear chromosome segregation
AFL94_16570	COG0741	lytic transglycosylase activity
AFL94_16570	COG0739	heme binding
AFL94_16585	COG1476	TRANSCRIPTIONal
AFL94_16590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AFL94_16595	COG0305	Participates in initiation and elongation during chromosome replication
AFL94_16605	COG0477	Major facilitator Superfamily
AFL94_16625	COG1846	Transcriptional regulator
AFL94_16640	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_16675	COG2351	hydroxyisourate hydrolase activity
AFL94_16685	COG2233	PERMEase
AFL94_16705	COG0531	amino acid
AFL94_16710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFL94_16730	COG4221	oxidoreductase activity
AFL94_16745	COG2814	Major facilitator Superfamily
AFL94_16750	COG1113	amino acid transport
AFL94_16760	COG1940	carbohydrate kinase activity
AFL94_16770	COG0673	inositol 2-dehydrogenase activity
AFL94_16780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFL94_16790	COG3962	Belongs to the TPP enzyme family
AFL94_16805	COG0673	inositol 2-dehydrogenase activity
AFL94_16810	COG1082	Xylose isomerase domain protein TIM barrel
AFL94_16815	COG2814	Major facilitator Superfamily
AFL94_16820	COG0589	response to stress
AFL94_16830	COG1609	Transcriptional regulator
AFL94_16835	COG0673	inositol 2-dehydrogenase activity
AFL94_16840	COG1082	Xylose isomerase domain protein TIM barrel
AFL94_16845	COG3718	enzyme involved in inositol metabolism
AFL94_16860	COG1609	Transcriptional regulator
AFL94_16870	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFL94_16885	COG1082	Xylose isomerase domain protein TIM barrel
AFL94_16890	COG0673	inositol 2-dehydrogenase activity
AFL94_16900	COG0673	inositol 2-dehydrogenase activity
AFL94_16915	COG2217	Heavy metal translocating P-type atpase
AFL94_16920	COG1132	(ABC) transporter
AFL94_16925	COG1053	succinate dehydrogenase
AFL94_16955	COG3257	ureidoglycine aminohydrolase activity
AFL94_16970	COG0346	lactoylglutathione lyase activity
AFL94_16985	COG2267	carboxylic ester hydrolase activity
AFL94_16990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFL94_17015	COG0318	PFAM AMP-dependent synthetase and ligase
AFL94_17025	COG1136	(ABC) transporter
AFL94_17055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AFL94_17060	COG0477	Major facilitator Superfamily
AFL94_17100	COG0798	PFAM Bile acid sodium symporter
AFL94_17115	COG1309	transcriptional regulator
AFL94_17120	COG2267	carboxylic ester hydrolase activity
AFL94_17130	COG1902	pentaerythritol trinitrate reductase activity
AFL94_17130	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFL94_17145	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_17150	COG0477	Major facilitator Superfamily
AFL94_17155	COG0477	Major facilitator Superfamily
AFL94_17160	COG0183	Belongs to the thiolase family
AFL94_17185	COG3547	Transposase (IS116 IS110 IS902 family)
AFL94_17190	COG3547	Transposase (IS116 IS110 IS902 family)
AFL94_17290	COG2161	toxin-antitoxin pair type II binding
AFL94_17330	COG1597	lipid kinase activity
AFL94_17355	COG0318	PFAM AMP-dependent synthetase and ligase
AFL94_17365	COG2133	pyrroloquinoline quinone binding
AFL94_17400	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AFL94_17405	COG0359	binds to the 23S rRNA
AFL94_17410	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AFL94_17420	COG0360	Binds together with S18 to 16S ribosomal RNA
AFL94_17425	COG2755	lipolytic protein G-D-S-L family
AFL94_17425	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AFL94_17430	COG0579	oxidoreductase
AFL94_17445	COG1362	aminopeptidase activity
AFL94_17455	COG2197	response regulator
AFL94_17460	COG4585	Histidine kinase
AFL94_17495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFL94_17555	COG1129	ABC transporter
AFL94_17560	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFL94_17570	COG1902	pentaerythritol trinitrate reductase activity
AFL94_17570	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFL94_17575	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AFL94_17575	COG2050	protein possibly involved in aromatic compounds catabolism
AFL94_17580	COG0183	Belongs to the thiolase family
AFL94_17585	COG1309	transcriptional regulator
AFL94_17600	COG2207	Transcriptional regulator
AFL94_17625	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_17655	COG2089	acid synthase
AFL94_17660	COG1442	glycosyl transferase family 8
AFL94_17660	COG1216	Glycosyl transferase, family 2
AFL94_17680	COG1260	myo-inositol-1-phosphate synthase
AFL94_17705	COG0492	ferredoxin-NADP+ reductase activity
AFL94_17710	COG3118	belongs to the thioredoxin family
AFL94_17720	COG1475	DNA binding
AFL94_17725	COG1192	Involved in chromosome partitioning
AFL94_17730	COG0357	Ribosomal RNA small subunit methyltransferase G
AFL94_17740	COG0706	membrane insertase activity
AFL94_17745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane