locus-tag	class	description
OW521_00025	COG3119	arylsulfatase activity
OW521_00035	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OW521_00070	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
OW521_00075	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
OW521_00085	COG2124	cytochrome p450
OW521_00115	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
OW521_00120	COG0439	Biotin carboxylase
OW521_00140	COG0583	DNA-binding transcription factor activity
OW521_00145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OW521_00160	COG0596	Alpha beta hydrolase
OW521_00190	COG1024	Enoyl-CoA hydratase
OW521_00195	COG1250	3-hydroxyacyl-CoA dehydrogenase
OW521_00210	COG2271	Major facilitator Superfamily
OW521_00240	COG2855	membrane
OW521_00270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OW521_00310	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OW521_00315	COG0121	glutamine amidotransferase
OW521_00320	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
OW521_00325	COG1104	cysteine desulfurase activity
OW521_00365	COG3654	unkown
OW521_00380	COG0747	negative chemotaxis
OW521_00395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OW521_00425	COG0183	Belongs to the thiolase family
OW521_00435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OW521_00475	COG0477	Major facilitator Superfamily
OW521_00480	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_00520	COG1414	Transcriptional regulator
OW521_00545	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_00560	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_00585	COG0477	Major facilitator Superfamily
OW521_00645	COG0747	negative chemotaxis
OW521_00675	COG2186	Transcriptional regulator
OW521_00735	COG1355	regulation of microtubule-based process
OW521_00745	COG2188	Transcriptional regulator
OW521_00785	COG3387	PFAM Glycoside hydrolase 15-related
OW521_00800	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OW521_00820	COG0145	ligase activity
OW521_00825	COG4647	ligase activity
OW521_00830	COG0145	ligase activity
OW521_00840	COG0667	Aldo Keto reductase
OW521_00860	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_00865	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_00915	COG3619	membrane
OW521_00920	COG1012	belongs to the aldehyde dehydrogenase family
OW521_00940	COG0395	ABC-type sugar transport system, permease component
OW521_00955	COG2186	Transcriptional regulator
OW521_00960	COG4948	Mandelate Racemase Muconate Lactonizing
OW521_00985	COG0179	Fumarylacetoacetate (FAA) hydrolase
OW521_00990	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_01000	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_01010	COG1937	Protein conserved in bacteria
OW521_01015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OW521_01030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OW521_01040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OW521_01130	COG1396	sequence-specific DNA binding
OW521_01135	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
OW521_01155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OW521_01175	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OW521_01190	COG2186	Transcriptional regulator
OW521_01195	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_01200	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OW521_01205	COG1609	Transcriptional regulator
OW521_01215	COG0427	acetyl-CoA hydrolase
OW521_01220	COG1960	acyl-CoA dehydrogenase activity
OW521_01230	COG1064	alcohol dehydrogenase
OW521_01260	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_01270	COG1172	Belongs to the binding-protein-dependent transport system permease family
OW521_01275	COG1129	ABC transporter
OW521_01285	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_01315	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_01320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_01325	COG2030	dehydratase
OW521_01350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OW521_01365	COG4569	acetaldehyde dehydrogenase (acetylating) activity
OW521_01380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OW521_01440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OW521_01450	COG2151	metal-sulfur cluster biosynthetic enzyme
OW521_01485	COG3350	monooxygenase activity
OW521_01610	COG1053	succinate dehydrogenase
OW521_01615	COG1414	Transcriptional regulator
OW521_01625	COG1053	succinate dehydrogenase
OW521_01640	COG0154	amidase activity
OW521_01645	COG0477	Major facilitator Superfamily
OW521_01655	COG2902	Dehydrogenase
OW521_01710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OW521_01715	COG1414	Transcriptional regulator
OW521_01740	COG2267	carboxylic ester hydrolase activity
OW521_01755	COG4638	Rieske (2fe-2S)
OW521_01765	COG0318	PFAM AMP-dependent synthetase and ligase
OW521_01770	COG3971	2-oxopent-4-enoate hydratase activity
OW521_01785	COG0559	Belongs to the binding-protein-dependent transport system permease family
OW521_01805	COG4569	acetaldehyde dehydrogenase (acetylating) activity
OW521_01825	COG1024	Enoyl-CoA hydratase
OW521_01845	COG2086	electron transfer activity
OW521_01850	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OW521_01865	COG3347	Dehydrogenase
OW521_01865	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_01870	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_01870	COG3321	synthase
OW521_01870	COG0604	alcohol dehydrogenase
OW521_01875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_01880	COG2814	Major facilitator Superfamily
OW521_01905	COG2365	Tyrosine phosphatase family
OW521_01920	COG0302	gtp cyclohydrolase
OW521_01930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OW521_01935	COG1215	transferase activity, transferring glycosyl groups
OW521_01950	COG2814	Major facilitator Superfamily
OW521_01955	COG0604	alcohol dehydrogenase
OW521_01975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
OW521_01975	COG0825	malonyl-CoA metabolic process
OW521_02015	COG1960	acyl-CoA dehydrogenase activity
OW521_02020	COG1960	acyl-CoA dehydrogenase activity
OW521_02040	COG1960	acyl-CoA dehydrogenase activity
OW521_02045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_02055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OW521_02060	COG1024	Enoyl-CoA hydratase
OW521_02080	COG0406	alpha-ribazole phosphatase activity
OW521_02105	COG2079	MmgE PrpD family protein
OW521_02110	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
OW521_02120	COG0563	adenylate kinase activity
OW521_02145	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
OW521_02150	COG0667	Aldo Keto reductase
OW521_02155	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OW521_02165	COG0183	Belongs to the thiolase family
OW521_02180	COG2124	cytochrome p450
OW521_02195	COG1024	Enoyl-CoA hydratase
OW521_02205	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
OW521_02210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_02245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_02250	COG2130	NADP-dependent
OW521_02275	COG2124	cytochrome p450
OW521_02295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OW521_02305	COG2814	Major facilitator Superfamily
OW521_02310	COG2814	Major facilitator Superfamily
OW521_02315	COG2814	Major facilitator Superfamily
OW521_02380	COG1473	amidohydrolase
OW521_02415	COG3547	Transposase (IS116 IS110 IS902 family)
OW521_02420	COG4974	Belongs to the 'phage' integrase family
OW521_02435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OW521_02590	COG0067	glutamate synthase
OW521_02590	COG0069	glutamate synthase activity
OW521_02590	COG0070	glutamate synthase
OW521_02595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
OW521_02600	COG0159	tryptophan synthase activity
OW521_02605	COG0133	tryptophan synthase activity
OW521_02610	COG0134	indole-3-glycerol-phosphate synthase activity
OW521_02630	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OW521_02640	COG0107	imidazoleglycerol-phosphate synthase activity
OW521_02645	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OW521_02650	COG0140	phosphoribosyl-ATP diphosphatase activity
OW521_02655	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
OW521_02660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OW521_02660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OW521_02685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OW521_02695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OW521_02700	COG0242	peptide deformylase activity
OW521_02710	COG3706	GGDEF domain
OW521_02775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OW521_02790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OW521_02820	COG0183	Belongs to the thiolase family
OW521_02825	COG1024	Enoyl-CoA hydratase
OW521_02825	COG1250	3-hydroxyacyl-CoA dehydrogenase
OW521_02835	COG0667	Aldo Keto reductase
OW521_02850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
OW521_02855	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OW521_02860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OW521_02865	COG0531	amino acid
OW521_02870	COG0569	domain protein
OW521_02895	COG0756	dUTP diphosphatase activity
OW521_02915	COG1435	thymidine kinase activity
OW521_02930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OW521_02930	COG1042	CoA-binding domain protein
OW521_02930	COG0045	succinate-CoA ligase (ADP-forming) activity
OW521_02935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OW521_02955	COG4988	ABC transporter
OW521_02960	COG1294	oxidase, subunit
OW521_02965	COG1271	oxidase subunit
OW521_03000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OW521_03005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OW521_03025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OW521_03030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OW521_03035	COG0508	dehydrogenase complex catalyzes the overall conversion of
OW521_03045	COG1764	response to oxidative stress
OW521_03050	COG0793	Belongs to the peptidase S41A family
OW521_03050	COG4946	Tricorn protease homolog
OW521_03055	COG1090	epimerase
OW521_03065	COG0321	lipoyl(octanoyl) transferase activity
OW521_03070	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OW521_03100	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
OW521_03105	COG0174	glutamine synthetase
OW521_03110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
OW521_03130	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OW521_03135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OW521_03150	COG0587	DNA-directed DNA polymerase activity
OW521_03160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OW521_03165	COG3599	regulation of cell shape
OW521_03175	COG1799	cell septum assembly
OW521_03180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OW521_03185	COG1496	oxidoreductase activity
OW521_03190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OW521_03200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OW521_03205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OW521_03215	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OW521_03220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OW521_03230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OW521_03235	COG0768	penicillin binding
OW521_03245	COG0275	rRNA processing
OW521_03250	COG2001	Belongs to the MraZ family
OW521_03260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OW521_03270	COG0142	geranyltranstransferase activity
OW521_03285	COG0515	serine threonine protein kinase
OW521_03285	COG2815	serine threonine protein kinase
OW521_03290	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
OW521_03310	COG1940	carbohydrate kinase activity
OW521_03320	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
OW521_03325	COG1192	Involved in chromosome partitioning
OW521_03345	COG1716	ATPase activity
OW521_03350	COG0509	glycine decarboxylation via glycine cleavage system
OW521_03355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OW521_03360	COG2814	Major facilitator Superfamily
OW521_03370	COG2824	Alkylphosphonate utilization operon protein PhnA
OW521_03380	COG1160	GTP binding
OW521_03390	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
OW521_03395	COG0287	Prephenate dehydrogenase
OW521_03410	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
OW521_03420	COG1301	dicarboxylic acid transport
OW521_03425	COG3290	protein histidine kinase activity
OW521_03430	COG4565	transcriptional regulatory protein
OW521_03440	COG2079	MmgE PrpD family protein
OW521_03445	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
OW521_03475	COG1595	DNA-templated transcription, initiation
OW521_03485	COG0494	nUDIX hydrolase
OW521_03490	COG0504	CTP synthase activity
OW521_03495	COG0497	DNA recombination
OW521_03500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OW521_03515	COG0647	UMP catabolic process
OW521_03555	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OW521_03570	COG2094	Belongs to the DNA glycosylase MPG family
OW521_03585	COG0165	Argininosuccinate lyase
OW521_03590	COG0137	argininosuccinate synthase activity
OW521_03595	COG1438	arginine binding
OW521_03600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
OW521_03605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OW521_03610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OW521_03615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
OW521_03620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
OW521_03650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OW521_03650	COG0072	phenylalanine-tRNA ligase activity
OW521_03655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
OW521_03660	COG2968	Membrane
OW521_03680	COG2814	Major facilitator Superfamily
OW521_03690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OW521_03695	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
OW521_03700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
OW521_03705	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
OW521_03725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
OW521_03735	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OW521_03740	COG0131	Imidazoleglycerol-phosphate dehydratase
OW521_03745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OW521_03755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OW521_03765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OW521_03775	COG2813	Specifically methylates the guanine in position
OW521_03780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
OW521_03785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OW521_03790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OW521_03800	COG2137	regulation of response to DNA damage stimulus
OW521_03805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
OW521_03820	COG1396	sequence-specific DNA binding
OW521_03825	COG1058	Belongs to the CinA family
OW521_03825	COG1546	Belongs to the CinA family
OW521_03835	COG1674	ftsk spoiiie
OW521_03840	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
OW521_03860	COG2801	Transposase and inactivated derivatives
OW521_03870	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
OW521_03880	COG0521	Mo-molybdopterin cofactor biosynthetic process
OW521_03900	COG5002	protein histidine kinase activity
OW521_03905	COG0745	RESPONSE REGULATOR receiver
OW521_03930	COG0612	Peptidase, M16
OW521_03935	COG1185	polyribonucleotide nucleotidyltransferase activity
OW521_03940	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
OW521_03945	COG3483	tryptophan 2,3-dioxygenase activity
OW521_03965	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OW521_03970	COG0436	Aminotransferase
OW521_03975	COG0590	tRNA wobble adenosine to inosine editing
OW521_03980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OW521_03985	COG0481	GTPase activity
OW521_03985	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
OW521_04000	COG0779	Required for maturation of 30S ribosomal subunits
OW521_04020	COG0076	glutamate decarboxylase activity
OW521_04030	COG0442	prolyl-tRNA aminoacylation
OW521_04035	COG1131	(ABC) transporter
OW521_04045	COG1309	transcriptional regulator
OW521_04055	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
OW521_04065	COG0750	zinc metalloprotease
OW521_04070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
OW521_04100	COG1960	acyl-CoA dehydrogenase activity
OW521_04110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OW521_04120	COG2801	Transposase and inactivated derivatives
OW521_04120	COG3415	Transposase
OW521_04125	COG0508	dehydrogenase complex catalyzes the overall conversion of
OW521_04130	COG0022	dehydrogenase e1 component
OW521_04140	COG1522	sequence-specific DNA binding
OW521_04155	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OW521_04165	COG3275	phosphorelay sensor kinase activity
OW521_04180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OW521_04190	COG0575	Belongs to the CDS family
OW521_04195	COG0233	cytoplasmic translational termination
OW521_04200	COG0528	UMP kinase activity
OW521_04205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OW521_04210	COG0052	Belongs to the universal ribosomal protein uS2 family
OW521_04220	COG1960	acyl-CoA dehydrogenase activity
OW521_04240	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OW521_04245	COG0667	Aldo Keto reductase
OW521_04260	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_04265	COG2326	polyphosphate kinase activity
OW521_04315	COG0297	glycogen (starch) synthase activity
OW521_04320	COG3300	MHYT domain
OW521_04320	COG5001	Diguanylate cyclase
OW521_04340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OW521_04355	COG0688	phosphatidylethanolamine metabolic process
OW521_04445	COG0784	Response regulator, receiver
OW521_04445	COG5002	protein histidine kinase activity
OW521_04445	COG2198	Histidine kinase
OW521_04450	COG5002	protein histidine kinase activity
OW521_04450	COG2205	protein histidine kinase activity
OW521_04450	COG0784	Response regulator, receiver
OW521_04460	COG2732	(Barnase) inhibitor
OW521_04495	COG3300	MHYT domain
OW521_04495	COG5001	Diguanylate cyclase
OW521_04550	COG2226	methyltransferase
OW521_04555	COG0789	Transcriptional regulator
OW521_04580	COG3118	belongs to the thioredoxin family
OW521_04615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OW521_04625	COG0701	Predicted permease
OW521_04645	COG0789	Transcriptional regulator
OW521_04655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OW521_04690	COG1475	DNA binding
OW521_04715	COG0577	efflux transmembrane transporter activity
OW521_04720	COG1136	(ABC) transporter
OW521_04735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OW521_04810	COG0789	Transcriptional regulator
OW521_04815	COG0071	Belongs to the small heat shock protein (HSP20) family
OW521_04820	COG0484	heat shock protein binding
OW521_04850	COG3237	CsbD-like
OW521_04920	COG5416	Lipopolysaccharide assembly protein A domain
OW521_04930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OW521_04975	COG0667	Aldo Keto reductase
OW521_04995	COG1309	transcriptional regulator
OW521_05015	COG0277	FAD linked oxidase domain protein
OW521_05020	COG0277	FAD linked oxidase domain protein
OW521_05060	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_05070	COG4974	Belongs to the 'phage' integrase family
OW521_05085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OW521_05100	COG0297	glycogen (starch) synthase activity
OW521_05110	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OW521_05140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OW521_05155	COG0358	DNA primase activity
OW521_05170	COG2197	response regulator
OW521_05175	COG4585	Histidine kinase
OW521_05180	COG0842	Transport permease protein
OW521_05185	COG1131	(ABC) transporter
OW521_05195	COG2801	Transposase and inactivated derivatives
OW521_05195	COG3415	Transposase
OW521_05200	COG0277	FAD linked oxidase domain protein
OW521_05210	COG0423	glycine-tRNA ligase activity
OW521_05240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OW521_05280	COG1940	carbohydrate kinase activity
OW521_05290	COG1228	amidohydrolase
OW521_05305	COG1486	melibiose metabolic process
OW521_05315	COG1063	alcohol dehydrogenase
OW521_05325	COG0673	inositol 2-dehydrogenase activity
OW521_05340	COG0395	ABC-type sugar transport system, permease component
OW521_05345	COG4209	transmembrane transport
OW521_05355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OW521_05360	COG0154	amidase activity
OW521_05365	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OW521_05375	COG0251	oxidation-reduction process
OW521_05380	COG0456	acetyltransferase
OW521_05385	COG0483	inositol monophosphate 1-phosphatase activity
OW521_05390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OW521_05420	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_05425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OW521_05435	COG2801	Transposase and inactivated derivatives
OW521_05435	COG3415	Transposase
OW521_05445	COG0393	Putative heavy-metal-binding
OW521_05450	COG1309	transcriptional regulator
OW521_05455	COG2409	Drug exporters of the RND superfamily
OW521_05460	COG0424	maF-like protein
OW521_05465	COG4770	biotin carboxylase activity
OW521_05470	COG0477	Major facilitator Superfamily
OW521_05475	COG2223	nitrite transmembrane transporter activity
OW521_05480	COG0243	molybdopterin cofactor binding
OW521_05550	COG1621	beta-fructofuranosidase activity
OW521_05555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OW521_05565	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OW521_05565	COG2146	nitrite reductase [NAD(P)H] activity
OW521_05615	COG0446	pyridine nucleotide-disulphide oxidoreductase
OW521_05620	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
OW521_05655	COG1988	membrane-bound metal-dependent
OW521_05675	COG3415	Transposase
OW521_05675	COG2801	Transposase and inactivated derivatives
OW521_05680	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OW521_05710	COG1215	transferase activity, transferring glycosyl groups
OW521_05720	COG3979	chitinase
OW521_05730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OW521_05745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OW521_05765	COG0193	aminoacyl-tRNA hydrolase activity
OW521_05770	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
OW521_05780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
OW521_05790	COG1309	transcriptional regulator
OW521_05800	COG0488	(ABC) transporter
OW521_05805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
OW521_05810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OW521_05815	COG3583	domain protein
OW521_05820	COG0084	hydrolase, TatD family'
OW521_05825	COG0714	Associated with various cellular activities
OW521_05875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
OW521_05930	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
OW521_05935	COG1482	cell wall glycoprotein biosynthetic process
OW521_05950	COG1494	fructose-1,6-bisphosphatase
OW521_05960	COG0288	reversible hydration of carbon dioxide
OW521_05965	COG0114	fumarate hydratase activity
OW521_06000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
OW521_06005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OW521_06020	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OW521_06035	COG3547	Transposase (IS116 IS110 IS902 family)
OW521_06050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OW521_06050	COG0357	Ribosomal RNA small subunit methyltransferase G
OW521_06070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OW521_06085	COG0673	inositol 2-dehydrogenase activity
OW521_06100	COG1653	transport
OW521_06105	COG1609	Transcriptional regulator
OW521_06110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OW521_06120	COG0673	inositol 2-dehydrogenase activity
OW521_06130	COG0395	ABC-type sugar transport system, permease component
OW521_06135	COG1175	transmembrane transport
OW521_06145	COG1609	Transcriptional regulator
OW521_06155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OW521_06170	COG1024	Enoyl-CoA hydratase
OW521_06180	COG1024	Enoyl-CoA hydratase
OW521_06190	COG0415	Belongs to the DNA photolyase family
OW521_06205	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OW521_06215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OW521_06235	COG1609	Transcriptional regulator
OW521_06260	COG0366	Alpha amylase catalytic
OW521_06290	COG1302	Protein conserved in bacteria
OW521_06320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OW521_06325	COG1609	Transcriptional regulator
OW521_06340	COG3848	Pyruvate phosphate dikinase
OW521_06340	COG0574	Belongs to the PEP-utilizing enzyme family
OW521_06360	COG2252	PERMEase
OW521_06365	COG0010	Belongs to the arginase family
OW521_06385	COG1472	Belongs to the glycosyl hydrolase 3 family
OW521_06400	COG0444	Belongs to the ABC transporter superfamily
OW521_06420	COG2801	Transposase and inactivated derivatives
OW521_06420	COG3415	Transposase
OW521_06425	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_06435	COG2186	Transcriptional regulator
OW521_06445	COG2376	Dihydroxyacetone kinase
OW521_06450	COG0698	ribose 5-phosphate isomerase
OW521_06455	COG0149	triose-phosphate isomerase activity
OW521_06460	COG1082	Xylose isomerase domain protein TIM barrel
OW521_06465	COG2084	Dehydrogenase
OW521_06470	COG2902	Dehydrogenase
OW521_06490	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
OW521_06505	COG1476	TRANSCRIPTIONal
OW521_06520	COG1280	lysine exporter protein (LysE YggA)
OW521_06535	COG1609	Transcriptional regulator
OW521_06540	COG0395	ABC-type sugar transport system, permease component
OW521_06545	COG1175	transmembrane transport
OW521_06550	COG1653	transport
OW521_06560	COG3706	GGDEF domain
OW521_06565	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_06590	COG4122	O-methyltransferase activity
OW521_06630	COG2733	membrane
OW521_06635	COG1984	allophanate hydrolase subunit 2
OW521_06640	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
OW521_06645	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OW521_06665	COG1819	glycosyl
OW521_06690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OW521_06710	COG0395	ABC-type sugar transport system, permease component
OW521_06715	COG1175	transmembrane transport
OW521_06725	COG1609	Transcriptional regulator
OW521_06750	COG1349	DNA-binding transcription factor activity
OW521_06760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OW521_06760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OW521_06760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OW521_06765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OW521_06785	COG3237	CsbD-like
OW521_06800	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
OW521_06820	COG2890	protein-(glutamine-N5) methyltransferase activity
OW521_06825	COG0477	Major facilitator Superfamily
OW521_06835	COG0745	RESPONSE REGULATOR receiver
OW521_06840	COG5002	protein histidine kinase activity
OW521_06845	COG0346	lactoylglutathione lyase activity
OW521_06855	COG0542	response to heat
OW521_06895	COG0673	inositol 2-dehydrogenase activity
OW521_06900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OW521_06905	COG1609	Transcriptional regulator
OW521_06910	COG0673	inositol 2-dehydrogenase activity
OW521_06920	COG3962	Belongs to the TPP enzyme family
OW521_06925	COG1012	belongs to the aldehyde dehydrogenase family
OW521_06935	COG1172	Belongs to the binding-protein-dependent transport system permease family
OW521_07015	COG2610	gluconate transmembrane transporter activity
OW521_07020	COG2084	Dehydrogenase
OW521_07030	COG2267	carboxylic ester hydrolase activity
OW521_07035	COG2186	Transcriptional regulator
OW521_07040	COG3360	Dodecin
OW521_07065	COG0667	Aldo Keto reductase
OW521_07075	COG0656	L-ascorbic acid biosynthetic process
OW521_07090	COG1796	DNA polymerase
OW521_07090	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
OW521_07095	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
OW521_07100	COG0829	nickel cation binding
OW521_07105	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
OW521_07110	COG0830	nickel cation binding
OW521_07115	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
OW521_07120	COG0804	urea catabolic process
OW521_07125	COG0832	Belongs to the urease beta subunit family
OW521_07130	COG0831	urea catabolic process
OW521_07140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_07160	COG0306	phosphate transporter
OW521_07165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OW521_07200	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OW521_07205	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
OW521_07220	COG2226	methyltransferase
OW521_07255	COG1461	Dihydroxyacetone kinase
OW521_07260	COG2376	Dihydroxyacetone kinase
OW521_07265	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
OW521_07270	COG1506	peptidase
OW521_07270	COG0823	Involved in the tonB-independent uptake of proteins
OW521_07290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
OW521_07295	COG0596	Alpha beta hydrolase
OW521_07350	COG2814	Major facilitator Superfamily
OW521_07355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
OW521_07385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OW521_07390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OW521_07395	COG0302	gtp cyclohydrolase
OW521_07400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OW521_07410	COG0037	tRNA processing
OW521_07420	COG2027	D-alanyl-D-alanine carboxypeptidase
OW521_07440	COG0561	phosphatase activity
OW521_07450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
OW521_07455	COG1597	lipid kinase activity
OW521_07465	COG0077	Prephenate dehydratase
OW521_07470	COG0425	Belongs to the sulfur carrier protein TusA family
OW521_07470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OW521_07475	COG3340	Belongs to the peptidase S51 family
OW521_07480	COG0154	amidase activity
OW521_07485	COG3104	oligopeptide transport
OW521_07505	COG0778	Nitroreductase
OW521_07510	COG2233	PERMEase
OW521_07515	COG1610	YqeY-like protein
OW521_07525	COG1929	Belongs to the glycerate kinase type-1 family
OW521_07535	COG4941	Belongs to the sigma-70 factor family
OW521_07540	COG0584	glycerophosphoryl diester phosphodiesterase
OW521_07565	COG0561	phosphatase activity
OW521_07605	COG1609	Transcriptional regulator
OW521_07630	COG3585	molybdate ion transport
OW521_07650	COG4770	biotin carboxylase activity
OW521_07655	COG1984	allophanate hydrolase subunit 2
OW521_07660	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OW521_07685	COG1716	ATPase activity
OW521_07700	COG0768	penicillin binding
OW521_07705	COG0515	serine threonine protein kinase
OW521_07710	COG0515	serine threonine protein kinase
OW521_07710	COG2815	serine threonine protein kinase
OW521_07720	COG3764	Sortase (surface protein transpeptidase)
OW521_07735	COG1595	DNA-templated transcription, initiation
OW521_07740	COG2169	Transcriptional regulator
OW521_07740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OW521_07750	COG2818	Glycosylase
OW521_07755	COG0640	Transcriptional regulator
OW521_07790	COG1331	Highly conserved protein containing a thioredoxin domain
OW521_07800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
OW521_07810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OW521_07815	COG2801	Transposase and inactivated derivatives
OW521_07815	COG3415	Transposase
OW521_07825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OW521_07835	COG2017	converts alpha-aldose to the beta-anomer
OW521_07845	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
OW521_07850	COG0183	Belongs to the thiolase family
OW521_07860	COG0559	Belongs to the binding-protein-dependent transport system permease family
OW521_07895	COG1252	NADH dehydrogenase
OW521_07920	COG0148	phosphopyruvate hydratase activity
OW521_07925	COG3956	TIGRFAM MazG family protein
OW521_07930	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OW521_07955	COG1079	Belongs to the binding-protein-dependent transport system permease family
OW521_07960	COG4603	Belongs to the binding-protein-dependent transport system permease family
OW521_07965	COG3845	ABC transporter
OW521_07970	COG1744	ABC transporter substrate-binding protein PnrA-like
OW521_07975	COG2130	NADP-dependent
OW521_07980	COG1764	response to oxidative stress
OW521_07985	COG1846	Transcriptional regulator
OW521_07990	COG1473	amidohydrolase
OW521_07990	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
OW521_08000	COG2009	succinate dehydrogenase
OW521_08015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OW521_08035	COG0180	Tryptophanyl-tRNA synthetase
OW521_08060	COG1131	(ABC) transporter
OW521_08070	COG2197	response regulator
OW521_08075	COG4585	Histidine kinase
OW521_08080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OW521_08085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OW521_08110	COG0531	amino acid
OW521_08115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OW521_08135	COG1122	ATPase activity
OW521_08180	COG4213	ABC transporter substrate-binding protein
OW521_08185	COG3639	organic phosphonate transmembrane transporter activity
OW521_08190	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
OW521_08195	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
OW521_08200	COG0673	inositol 2-dehydrogenase activity
OW521_08225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OW521_08240	COG2838	Isocitrate dehydrogenase
OW521_08250	COG0138	bifunctional purine biosynthesis protein purh
OW521_08260	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
OW521_08265	COG2271	Major facilitator Superfamily
OW521_08295	COG0179	Fumarylacetoacetate (FAA) hydrolase
OW521_08310	COG2814	Major facilitator Superfamily
OW521_08315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OW521_08320	COG2268	Band 7 protein
OW521_08340	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
OW521_08370	COG1116	anion transmembrane transporter activity
OW521_08445	COG0492	ferredoxin-NADP+ reductase activity
OW521_08560	COG0531	amino acid
OW521_08575	COG0477	Major facilitator Superfamily
OW521_08585	COG0667	Aldo Keto reductase
OW521_08590	COG1501	Belongs to the glycosyl hydrolase 31 family
OW521_08595	COG3387	PFAM Glycoside hydrolase 15-related
OW521_08605	COG0395	ABC-type sugar transport system, permease component
OW521_08610	COG1175	transmembrane transport
OW521_08615	COG1846	Transcriptional regulator
OW521_08615	COG1940	carbohydrate kinase activity
OW521_08620	COG1309	transcriptional regulator
OW521_08655	COG0640	Transcriptional regulator
OW521_08670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OW521_08705	COG2188	Transcriptional regulator
OW521_08725	COG0149	triose-phosphate isomerase activity
OW521_08730	COG2271	Major facilitator Superfamily
OW521_08735	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_08740	COG1250	3-hydroxyacyl-CoA dehydrogenase
OW521_08745	COG0698	ribose 5-phosphate isomerase
OW521_08750	COG2376	Dihydroxyacetone kinase
OW521_08765	COG1902	pentaerythritol trinitrate reductase activity
OW521_08780	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
OW521_08785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OW521_08795	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
OW521_08830	COG1401	restriction endodeoxyribonuclease activity
OW521_08845	COG3142	Participates in the control of copper homeostasis
OW521_08865	COG0477	Major facilitator Superfamily
OW521_08875	COG0028	Belongs to the TPP enzyme family
OW521_08900	COG1396	sequence-specific DNA binding
OW521_08955	COG1760	l-serine dehydratase
OW521_08980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OW521_09005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OW521_09030	COG0517	IMP dehydrogenase activity
OW521_09030	COG4175	Glycine betaine
OW521_09035	COG4176	ABC-type proline glycine betaine transport system permease component
OW521_09045	COG0477	Major facilitator Superfamily
OW521_09065	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
OW521_09080	COG2188	Transcriptional regulator
OW521_09085	COG3718	enzyme involved in inositol metabolism
OW521_09090	COG0673	inositol 2-dehydrogenase activity
OW521_09100	COG0673	inositol 2-dehydrogenase activity
OW521_09105	COG0673	inositol 2-dehydrogenase activity
OW521_09110	COG0673	inositol 2-dehydrogenase activity
OW521_09130	COG1609	Transcriptional regulator
OW521_09150	COG0659	secondary active sulfate transmembrane transporter activity
OW521_09155	COG1082	Xylose isomerase domain protein TIM barrel
OW521_09160	COG0673	inositol 2-dehydrogenase activity
OW521_09175	COG3962	Belongs to the TPP enzyme family
OW521_09190	COG1942	4-Oxalocrotonate Tautomerase
OW521_09200	COG0045	succinate-CoA ligase (ADP-forming) activity
OW521_09210	COG0483	inositol monophosphate 1-phosphatase activity
OW521_09260	COG0494	nUDIX hydrolase
OW521_09280	COG1132	(ABC) transporter
OW521_09285	COG0488	(ABC) transporter
OW521_09300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OW521_09305	COG0765	amino acid transport
OW521_09310	COG1126	abc transporter atp-binding protein
OW521_09320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OW521_09340	COG0746	molybdenum cofactor guanylyltransferase activity
OW521_09355	COG0739	heme binding
OW521_09370	COG2814	Major facilitator Superfamily
OW521_09380	COG1278	Cold shock
OW521_09405	COG0583	DNA-binding transcription factor activity
OW521_09415	COG0745	RESPONSE REGULATOR receiver
OW521_09430	COG0328	RNA-DNA hybrid ribonuclease activity
OW521_09435	COG0459	protein refolding
OW521_09480	COG3591	Belongs to the peptidase S1B family
OW521_09480	COG1864	DNA RNA non-specific endonuclease
OW521_09490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OW521_09495	COG0509	glycine decarboxylation via glycine cleavage system
OW521_09500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OW521_09505	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OW521_09505	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OW521_09515	COG0477	Major facilitator Superfamily
OW521_09545	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
OW521_09555	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OW521_09560	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OW521_09570	COG1987	bacterial-type flagellum assembly
OW521_09575	COG1338	Plays a role in the flagellum-specific transport system
OW521_09625	COG1360	Flagellar Motor Protein
OW521_09630	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
OW521_09640	COG0390	transport system, permease component
OW521_09665	COG3842	ATPase activity
OW521_09690	COG2205	protein histidine kinase activity
OW521_09705	COG0671	phosphoesterase, PA-phosphatase related
OW521_09725	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OW521_09730	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OW521_09745	COG0477	Major facilitator Superfamily
OW521_09765	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
OW521_09785	COG1157	protein secretion by the type III secretion system
OW521_09795	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OW521_09800	COG1766	The M ring may be actively involved in energy transduction
OW521_09805	COG1677	Flagellar hook-basal body complex protein FliE
OW521_09815	COG1815	bacterial-type flagellum-dependent cell motility
OW521_09835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OW521_09845	COG1256	bacterial-type flagellum assembly
OW521_09845	COG4786	Flagellar basal body rod
OW521_09850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OW521_09855	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
OW521_09895	COG0483	inositol monophosphate 1-phosphatase activity
OW521_09900	COG3842	ATPase activity
OW521_09905	COG1177	transmembrane transport
OW521_09935	COG0640	Transcriptional regulator
OW521_09945	COG4565	transcriptional regulatory protein
OW521_09950	COG3290	protein histidine kinase activity
OW521_09955	COG1116	anion transmembrane transporter activity
OW521_09970	COG0154	amidase activity
OW521_09980	COG0402	S-adenosylhomocysteine deaminase activity
OW521_10025	COG1335	isochorismatase
OW521_10030	COG0747	negative chemotaxis
OW521_10055	COG0444	Belongs to the ABC transporter superfamily
OW521_10065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OW521_10075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OW521_10080	COG0667	Aldo Keto reductase
OW521_10100	COG0395	ABC-type sugar transport system, permease component
OW521_10105	COG1175	transmembrane transport
OW521_10115	COG0366	Alpha amylase catalytic
OW521_10120	COG1846	Transcriptional regulator
OW521_10120	COG1940	carbohydrate kinase activity
OW521_10130	COG2203	Gaf domain
OW521_10130	COG3706	GGDEF domain
OW521_10130	COG4251	negative regulation of phosphorylation
OW521_10130	COG5001	Diguanylate cyclase
OW521_10135	COG2199	diguanylate cyclase activity
OW521_10155	COG3239	Fatty acid desaturase
OW521_10165	COG2160	L-arabinose isomerase activity
OW521_10180	COG1609	Transcriptional regulator
OW521_10215	COG0673	inositol 2-dehydrogenase activity
OW521_10220	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_10235	COG1175	transmembrane transport
OW521_10240	COG3386	PFAM SMP-30 Gluconolaconase
OW521_10245	COG4948	Mandelate Racemase Muconate Lactonizing
OW521_10285	COG0667	Aldo Keto reductase
OW521_10290	COG1621	beta-fructofuranosidase activity
OW521_10305	COG0395	ABC-type sugar transport system, permease component
OW521_10310	COG4209	transmembrane transport
OW521_10335	COG0395	ABC-type sugar transport system, permease component
OW521_10350	COG1609	Transcriptional regulator
OW521_10355	COG1621	beta-fructofuranosidase activity
OW521_10390	COG3842	ATPase activity
OW521_10430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OW521_10435	COG0366	Alpha amylase catalytic
OW521_10440	COG0366	Alpha amylase catalytic
OW521_10470	COG0215	cysteine-tRNA ligase activity
OW521_10475	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
OW521_10480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
OW521_10500	COG5002	protein histidine kinase activity
OW521_10510	COG0588	phosphoglycerate mutase activity
OW521_10530	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
OW521_10535	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OW521_10600	COG0656	L-ascorbic acid biosynthetic process
OW521_10615	COG2153	protein acetylation
OW521_10625	COG0604	alcohol dehydrogenase
OW521_10640	COG2146	nitrite reductase [NAD(P)H] activity
OW521_10640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OW521_10650	COG1968	undecaprenyl-diphosphatase activity
OW521_10665	COG1505	serine-type exopeptidase activity
OW521_10675	COG2814	Major facilitator Superfamily
OW521_10680	COG0514	ATP-dependent DNA helicase (RecQ)
OW521_10700	COG1017	nitric oxide dioxygenase activity
OW521_10700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OW521_10710	COG0574	Belongs to the PEP-utilizing enzyme family
OW521_10710	COG3848	Pyruvate phosphate dikinase
OW521_10715	COG2814	Major facilitator Superfamily
OW521_10720	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
OW521_10730	COG2188	Transcriptional regulator
OW521_10740	COG0601	transmembrane transport
OW521_10745	COG0444	Belongs to the ABC transporter superfamily
OW521_10750	COG4608	Belongs to the ABC transporter superfamily
OW521_10760	COG1940	carbohydrate kinase activity
OW521_10765	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
OW521_10780	COG1511	domain protein
OW521_10785	COG1309	transcriptional regulator
OW521_10795	COG0697	spore germination
OW521_10800	COG0583	DNA-binding transcription factor activity
OW521_10820	COG0745	RESPONSE REGULATOR receiver
OW521_10825	COG2205	protein histidine kinase activity
OW521_10840	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OW521_10840	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OW521_10845	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OW521_10880	COG0363	glucosamine-6-phosphate deaminase activity
OW521_10885	COG4821	SIS domain
OW521_10890	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OW521_10900	COG1609	Transcriptional regulator
OW521_10905	COG0477	Major facilitator Superfamily
OW521_10910	COG1309	transcriptional regulator
OW521_10915	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
OW521_10930	COG1254	Belongs to the acylphosphatase family
OW521_10955	COG4974	Belongs to the 'phage' integrase family
OW521_10975	COG1621	beta-fructofuranosidase activity
OW521_10985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OW521_10990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
OW521_11030	COG1070	Carbohydrate kinase
OW521_11035	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_11035	COG3347	Dehydrogenase
OW521_11070	COG0475	glutathione-regulated potassium exporter activity
OW521_11070	COG0569	domain protein
OW521_11090	COG1201	RNA secondary structure unwinding
OW521_11095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OW521_11100	COG2364	Membrane
OW521_11130	COG0564	pseudouridine synthase activity
OW521_11160	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
OW521_11170	COG1215	transferase activity, transferring glycosyl groups
OW521_11180	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
OW521_11200	COG0673	inositol 2-dehydrogenase activity
OW521_11215	COG0673	inositol 2-dehydrogenase activity
OW521_11220	COG1609	Transcriptional regulator
OW521_11225	COG0477	Major facilitator Superfamily
OW521_11230	COG3254	rhamnose metabolic process
OW521_11235	COG1960	acyl-CoA dehydrogenase activity
OW521_11280	COG0343	queuine tRNA-ribosyltransferase activity
OW521_11300	COG0477	Major facilitator Superfamily
OW521_11320	COG1476	TRANSCRIPTIONal
OW521_11330	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OW521_11365	COG0395	ABC-type sugar transport system, permease component
OW521_11380	COG0673	inositol 2-dehydrogenase activity
OW521_11390	COG0477	Major facilitator Superfamily
OW521_11405	COG1309	transcriptional regulator
OW521_11430	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OW521_11435	COG0386	Belongs to the glutathione peroxidase family
OW521_11450	COG1846	Transcriptional regulator
OW521_11465	COG1012	belongs to the aldehyde dehydrogenase family
OW521_11480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OW521_11480	COG3323	Protein of unknown function (DUF1653)
OW521_11495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OW521_11505	COG1131	(ABC) transporter
OW521_11525	COG1846	Transcriptional regulator
OW521_11580	COG0047	phosphoribosylformylglycinamidine synthase activity
OW521_11585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OW521_11610	COG0395	ABC-type sugar transport system, permease component
OW521_11615	COG1175	transmembrane transport
OW521_11620	COG1653	transport
OW521_11630	COG2315	Protein conserved in bacteria
OW521_11640	COG1832	CoA-binding protein
OW521_11675	COG1215	transferase activity, transferring glycosyl groups
OW521_11700	COG3266	domain, Protein
OW521_11705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OW521_11710	COG0187	DNA topoisomerase II activity
OW521_11715	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
OW521_11720	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OW521_11725	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
OW521_11730	COG0592	DNA-directed DNA polymerase activity
OW521_11735	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
OW521_11740	COG0230	Belongs to the bacterial ribosomal protein bL34 family
OW521_11745	COG0594	ribonuclease P activity
OW521_11750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
OW521_11755	COG0706	membrane insertase activity
OW521_11765	COG0357	Ribosomal RNA small subunit methyltransferase G
OW521_11770	COG1192	Involved in chromosome partitioning
OW521_11795	COG3118	belongs to the thioredoxin family
OW521_11800	COG0492	ferredoxin-NADP+ reductase activity
OW521_11820	COG0617	tRNA 3'-terminal CCA addition
OW521_11825	COG0406	alpha-ribazole phosphatase activity
OW521_11845	COG2910	NAD(P)H-binding
OW521_11850	COG1733	regulation of RNA biosynthetic process
OW521_11865	COG4585	Histidine kinase
OW521_11870	COG2197	response regulator
OW521_11875	COG0768	penicillin binding
OW521_11885	COG1309	transcriptional regulator
OW521_11890	COG0488	(ABC) transporter
OW521_11900	COG3226	Transcriptional regulator
OW521_11905	COG0738	Major facilitator superfamily
OW521_11915	COG1136	(ABC) transporter
OW521_11915	COG0577	efflux transmembrane transporter activity
OW521_11920	COG1136	(ABC) transporter
OW521_11935	COG1131	(ABC) transporter
OW521_11945	COG4585	Histidine kinase
OW521_11950	COG2197	response regulator
OW521_11955	COG1362	aminopeptidase activity
OW521_11965	COG1742	UPF0060 membrane protein
OW521_11970	COG0360	Binds together with S18 to 16S ribosomal RNA
OW521_11980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OW521_11985	COG0359	binds to the 23S rRNA
OW521_12010	COG0305	Participates in initiation and elongation during chromosome replication
OW521_12015	COG1607	acyl-coa hydrolase
OW521_12020	COG2259	Doxx family
OW521_12065	COG1937	Protein conserved in bacteria
OW521_12080	COG0395	ABC-type sugar transport system, permease component
OW521_12085	COG3525	Glycosyl hydrolase, family 20, catalytic domain
OW521_12090	COG1414	Transcriptional regulator
OW521_12105	COG1414	Transcriptional regulator
OW521_12120	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
OW521_12130	COG2610	gluconate transmembrane transporter activity
OW521_12145	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
OW521_12155	COG0477	Major facilitator Superfamily
OW521_12160	COG1414	Transcriptional regulator
OW521_12165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OW521_12170	COG1082	Xylose isomerase domain protein TIM barrel
OW521_12170	COG3185	4-Hydroxyphenylpyruvate dioxygenase
OW521_12175	COG3485	protocatechuate 3,4-dioxygenase
OW521_12195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OW521_12200	COG0183	Belongs to the thiolase family
OW521_12210	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OW521_12235	COG1011	Hydrolase
OW521_12355	COG1278	Cold shock
OW521_12380	COG2271	Major facilitator Superfamily
OW521_12385	COG0506	proline dehydrogenase activity
OW521_12395	COG1970	mechanosensitive ion channel activity
OW521_12425	COG2017	converts alpha-aldose to the beta-anomer
OW521_12430	COG1940	carbohydrate kinase activity
OW521_12435	COG0277	FAD linked oxidase domain protein
OW521_12440	COG2115	Belongs to the xylose isomerase family
OW521_12445	COG1070	Carbohydrate kinase
OW521_12490	COG0673	inositol 2-dehydrogenase activity
OW521_12500	COG1175	transmembrane transport
OW521_12505	COG1653	transport
OW521_12515	COG2059	Chromate
OW521_12550	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
OW521_12555	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
OW521_12560	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
OW521_12585	COG4221	oxidoreductase activity
OW521_12615	COG0596	Alpha beta hydrolase
OW521_12630	COG1802	Transcriptional regulator
OW521_12645	COG3971	2-oxopent-4-enoate hydratase activity
OW521_12660	COG0436	Aminotransferase
OW521_12665	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OW521_12675	COG0583	DNA-binding transcription factor activity
OW521_12680	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OW521_12685	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
OW521_12690	COG1984	allophanate hydrolase subunit 2
OW521_12695	COG0477	Major facilitator Superfamily
OW521_12700	COG4221	oxidoreductase activity
OW521_12705	COG1607	acyl-coa hydrolase
OW521_12725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OW521_12740	COG1950	PFAM Membrane protein of
OW521_12745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OW521_12755	COG0022	dehydrogenase e1 component
OW521_12760	COG0508	dehydrogenase complex catalyzes the overall conversion of
OW521_12780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OW521_12805	COG1309	transcriptional regulator
OW521_12810	COG0673	inositol 2-dehydrogenase activity
OW521_12830	COG0686	Belongs to the AlaDH PNT family
OW521_12845	COG2072	flavoprotein involved in K transport
OW521_12860	COG1309	transcriptional regulator
OW521_12865	COG1960	acyl-CoA dehydrogenase activity
OW521_12875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OW521_12880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OW521_12890	COG2213	PTS system mannitol-specific
OW521_12890	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OW521_12895	COG0246	Mannitol dehydrogenase
OW521_12900	COG1846	Transcriptional regulator
OW521_12915	COG1846	Transcriptional regulator
OW521_12920	COG2814	Major facilitator Superfamily
OW521_12925	COG0477	Major facilitator Superfamily
OW521_12930	COG0477	Major facilitator Superfamily
OW521_12935	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OW521_12945	COG1309	transcriptional regulator
OW521_12950	COG0281	malic enzyme
OW521_12970	COG2197	response regulator
OW521_12990	COG1280	lysine exporter protein (LysE YggA)
OW521_12995	COG1522	sequence-specific DNA binding
OW521_13020	COG0477	Major facilitator Superfamily
OW521_13050	COG0436	Aminotransferase
OW521_13060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OW521_13070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OW521_13100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OW521_13105	COG0179	Fumarylacetoacetate (FAA) hydrolase
OW521_13115	COG1027	Aspartate ammonia-lyase
OW521_13125	COG2186	Transcriptional regulator
OW521_13160	COG4154	Belongs to the RbsD FucU family
OW521_13165	COG1414	Transcriptional regulator
OW521_13175	COG3012	SEC-C Motif Domain Protein
OW521_13245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OW521_13250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
OW521_13255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OW521_13260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OW521_13280	COG0776	regulation of translation
OW521_13305	COG2318	DinB family
OW521_13330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OW521_13335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OW521_13345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OW521_13350	COG3387	PFAM Glycoside hydrolase 15-related
OW521_13360	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
OW521_13370	COG1309	transcriptional regulator
OW521_13375	COG0583	DNA-binding transcription factor activity
OW521_13405	COG0717	Belongs to the dCTP deaminase family
OW521_13410	COG0475	glutathione-regulated potassium exporter activity
OW521_13420	COG0363	glucosamine-6-phosphate deaminase activity
OW521_13425	COG1472	Belongs to the glycosyl hydrolase 3 family
OW521_13440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OW521_13440	COG2111	Na H antiporter
OW521_13445	COG1006	Multisubunit Na H antiporter MnhC subunit
OW521_13450	COG0651	ATP synthesis coupled electron transport
OW521_13460	COG2212	antiporter activity
OW521_13465	COG1320	monovalent cation:proton antiporter activity
OW521_13480	COG4721	ABC-type cobalt transport system, permease component
OW521_13490	COG1122	ATPase activity
OW521_13500	COG2801	Transposase and inactivated derivatives
OW521_13500	COG3415	Transposase
OW521_13510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OW521_13520	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
OW521_13555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OW521_13575	COG1953	Uracil, thiamine, allantoin
OW521_13585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OW521_13590	COG3559	Exporter of polyketide antibiotics
OW521_13595	COG1131	(ABC) transporter
OW521_13600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OW521_13605	COG0477	Major facilitator Superfamily
OW521_13610	COG1957	nucleoside hydrolase
OW521_13615	COG1609	Transcriptional regulator
OW521_13620	COG1280	lysine exporter protein (LysE YggA)
OW521_13640	COG4941	Belongs to the sigma-70 factor family
OW521_13645	COG3795	YCII-related domain
OW521_13650	COG2226	methyltransferase
OW521_13735	COG3739	integral membrane protein
OW521_13740	COG0443	Heat shock 70 kDa protein
OW521_13745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OW521_13750	COG0484	heat shock protein binding
OW521_13755	COG0789	Transcriptional regulator
OW521_13790	COG0251	oxidation-reduction process
OW521_13795	COG1113	amino acid transport
OW521_13805	COG3177	Filamentation induced by cAMP protein fic
OW521_13810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
OW521_13840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OW521_13850	COG1846	Transcriptional regulator
OW521_13855	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
OW521_13880	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_13890	COG2267	carboxylic ester hydrolase activity
OW521_13910	COG1012	belongs to the aldehyde dehydrogenase family
OW521_13915	COG2271	Major facilitator Superfamily
OW521_13920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OW521_13925	COG2807	transmembrane transport
OW521_13930	COG0477	Major facilitator Superfamily
OW521_13935	COG1473	amidohydrolase
OW521_13975	COG0667	Aldo Keto reductase
OW521_13995	COG0135	phosphoribosylanthranilate isomerase activity
OW521_14020	COG3304	Inner membrane component domain
OW521_14025	COG0028	Belongs to the TPP enzyme family
OW521_14060	COG0542	response to heat
OW521_14075	COG0640	Transcriptional regulator
OW521_14090	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
OW521_14125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OW521_14130	COG0765	amino acid transport
OW521_14140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OW521_14175	COG0765	amino acid transport
OW521_14205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OW521_14210	COG1929	Belongs to the glycerate kinase type-1 family
OW521_14215	COG3960	tartronate-semialdehyde synthase activity
OW521_14220	COG2084	Dehydrogenase
OW521_14225	COG3622	Belongs to the hyi family
OW521_14240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OW521_14245	COG1454	alcohol dehydrogenase
OW521_14315	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
OW521_14360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OW521_14365	COG1228	amidohydrolase
OW521_14370	COG1609	Transcriptional regulator
OW521_14380	COG1178	ABC-type Fe3 transport system permease component
OW521_14385	COG3842	ATPase activity
OW521_14435	COG0395	ABC-type sugar transport system, permease component
OW521_14440	COG1175	transmembrane transport
OW521_14445	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OW521_14460	COG3842	ATPase activity
OW521_14465	COG1737	Transcriptional regulator
OW521_14475	COG2267	carboxylic ester hydrolase activity
OW521_14520	COG0698	ribose 5-phosphate isomerase
OW521_14525	COG2376	Dihydroxyacetone kinase
OW521_14530	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_14535	COG1082	Xylose isomerase domain protein TIM barrel
OW521_14540	COG0477	Major facilitator Superfamily
OW521_14545	COG3959	Transketolase, thiamine diphosphate binding domain
OW521_14550	COG3958	Transketolase
OW521_14610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OW521_14645	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_14660	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_14705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OW521_14705	COG4499	WXG100 protein secretion system (Wss), protein YukC
OW521_14715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OW521_14720	COG0563	adenylate kinase activity
OW521_14725	COG3387	PFAM Glycoside hydrolase 15-related
OW521_14730	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
OW521_14740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OW521_14765	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OW521_14770	COG3257	ureidoglycine aminohydrolase activity
OW521_14780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OW521_14790	COG1414	Transcriptional regulator
OW521_14795	COG2233	PERMEase
OW521_14820	COG0590	tRNA wobble adenosine to inosine editing
OW521_14825	COG2252	PERMEase
OW521_14830	COG3608	succinylglutamate desuccinylase aspartoacylase
OW521_14830	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
OW521_14850	COG0741	lytic transglycosylase activity
OW521_14850	COG1196	nuclear chromosome segregation
OW521_14850	COG0739	heme binding
OW521_14865	COG2271	Major facilitator Superfamily
OW521_14875	COG3340	Belongs to the peptidase S51 family
OW521_14885	COG4126	flavin adenine dinucleotide binding
OW521_14985	COG1953	Uracil, thiamine, allantoin
OW521_15000	COG2066	Belongs to the glutaminase family
OW521_15005	COG1301	dicarboxylic acid transport
OW521_15035	COG0151	Belongs to the GarS family
OW521_15040	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
OW521_15060	COG1132	(ABC) transporter
OW521_15065	COG1132	(ABC) transporter
OW521_15070	COG1408	metallophosphoesterase
OW521_15075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OW521_15110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
OW521_15125	COG0395	ABC-type sugar transport system, permease component
OW521_15130	COG1175	transmembrane transport
OW521_15140	COG1609	Transcriptional regulator
OW521_15145	COG1349	DNA-binding transcription factor activity
OW521_15155	COG0395	ABC-type sugar transport system, permease component
OW521_15160	COG1175	transmembrane transport
OW521_15170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OW521_15200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OW521_15200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OW521_15240	COG1111	helicase
OW521_15240	COG1205	dead DEAH box helicase
OW521_15250	COG1054	Belongs to the UPF0176 family
OW521_15275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OW521_15275	COG1754	DNA topoisomerase type I activity
OW521_15290	COG0248	Ppx GppA phosphatase
OW521_15295	COG1082	Xylose isomerase domain protein TIM barrel
OW521_15300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OW521_15305	COG0598	Magnesium transport protein CorA
OW521_15310	COG0569	domain protein
OW521_15315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OW521_15320	COG0123	including yeast histone deacetylase and acetoin utilization protein
OW521_15325	COG0640	Transcriptional regulator
OW521_15340	COG1609	Transcriptional regulator
OW521_15345	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OW521_15370	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
OW521_15390	COG0406	alpha-ribazole phosphatase activity
OW521_15400	COG0785	Cytochrome C biogenesis protein
OW521_15410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OW521_15435	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
OW521_15470	COG0183	Belongs to the thiolase family
OW521_15475	COG1024	Enoyl-CoA hydratase
OW521_15480	COG1250	3-hydroxyacyl-CoA dehydrogenase
OW521_15495	COG0673	inositol 2-dehydrogenase activity
OW521_15505	COG0395	ABC-type sugar transport system, permease component
OW521_15515	COG2182	Extracellular solute-binding protein
OW521_15520	COG1609	Transcriptional regulator
OW521_15540	COG1012	belongs to the aldehyde dehydrogenase family
OW521_15540	COG2030	dehydratase
OW521_15565	COG2050	protein possibly involved in aromatic compounds catabolism
OW521_15585	COG0747	negative chemotaxis
OW521_15595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OW521_15615	COG0745	RESPONSE REGULATOR receiver
OW521_15625	COG5002	protein histidine kinase activity
OW521_15635	COG1316	TRANSCRIPTIONal
OW521_15695	COG2894	cell division
OW521_15720	COG0745	RESPONSE REGULATOR receiver
OW521_15735	COG3396	Phenylacetate-CoA oxygenase
OW521_15740	COG3460	Phenylacetate-CoA oxygenase
OW521_15745	COG3396	Phenylacetate-CoA oxygenase
OW521_15750	COG2151	metal-sulfur cluster biosynthetic enzyme
OW521_15755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OW521_15775	COG5001	Diguanylate cyclase
OW521_15785	COG1316	TRANSCRIPTIONal
OW521_15810	COG0640	Transcriptional regulator
OW521_15815	COG1316	TRANSCRIPTIONal
OW521_15820	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OW521_15825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OW521_15830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OW521_15850	COG0489	protein tyrosine kinase activity
OW521_15855	COG0438	transferase activity, transferring glycosyl groups
OW521_15925	COG0022	dehydrogenase e1 component
OW521_15930	COG0508	dehydrogenase complex catalyzes the overall conversion of
OW521_15940	COG3344	reverse transcriptase
OW521_15995	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
OW521_16000	COG0562	UDP-galactopyranose mutase
OW521_16005	COG1716	ATPase activity
OW521_16005	COG5001	Diguanylate cyclase
OW521_16020	COG1349	DNA-binding transcription factor activity
OW521_16025	COG0640	Transcriptional regulator
OW521_16035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OW521_16045	COG0800	Aldolase
OW521_16050	COG2271	Major facilitator Superfamily
OW521_16085	COG0596	Alpha beta hydrolase
OW521_16090	COG0701	Predicted permease
OW521_16110	COG0438	transferase activity, transferring glycosyl groups
OW521_16125	COG1175	transmembrane transport
OW521_16130	COG0395	ABC-type sugar transport system, permease component
OW521_16140	COG1609	Transcriptional regulator
OW521_16145	COG4948	Mandelate Racemase Muconate Lactonizing
OW521_16150	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
OW521_16155	COG1126	abc transporter atp-binding protein
OW521_16160	COG0765	amino acid transport
OW521_16170	COG1169	isochorismate synthase
OW521_16175	COG2226	methyltransferase
OW521_16185	COG0142	geranyltranstransferase activity
OW521_16200	COG2860	membrane
OW521_16210	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OW521_16215	COG0175	sulfate reduction
OW521_16235	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
OW521_16245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OW521_16250	COG1648	precorrin-2 dehydrogenase activity
OW521_16250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OW521_16260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OW521_16260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OW521_16265	COG2186	Transcriptional regulator
OW521_16275	COG2508	Transcriptional regulator
OW521_16275	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
OW521_16280	COG1012	belongs to the aldehyde dehydrogenase family
OW521_16330	COG0531	amino acid
OW521_16350	COG0531	amino acid
OW521_16355	COG0501	Belongs to the peptidase M48B family
OW521_16365	COG2837	iron assimilation
OW521_16375	COG0672	)-iron permease
OW521_16380	COG1666	GTP binding
OW521_16410	COG1131	(ABC) transporter
OW521_16415	COG1309	transcriptional regulator
OW521_16420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OW521_16430	COG0318	PFAM AMP-dependent synthetase and ligase
OW521_16450	COG0346	lactoylglutathione lyase activity
OW521_16520	COG1388	LysM domain
OW521_16520	COG3942	CHAP domain
OW521_16535	COG1940	carbohydrate kinase activity
OW521_16540	COG0366	Alpha amylase catalytic
OW521_16545	COG4989	oxidoreductase activity
OW521_16555	COG2182	Extracellular solute-binding protein
OW521_16560	COG1175	transmembrane transport
OW521_16565	COG0395	ABC-type sugar transport system, permease component
OW521_16570	COG4948	Mandelate Racemase Muconate Lactonizing
OW521_16580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OW521_16610	COG2030	dehydratase
OW521_16615	COG2030	dehydratase
OW521_16620	COG0738	Major facilitator superfamily
OW521_16625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
OW521_16640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OW521_16655	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
OW521_16665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
OW521_16670	COG0456	acetyltransferase
OW521_16675	COG0745	RESPONSE REGULATOR receiver
OW521_16685	COG3485	protocatechuate 3,4-dioxygenase
OW521_16695	COG0354	folic acid binding
OW521_16745	COG2197	response regulator
OW521_16750	COG0436	Aminotransferase
OW521_16770	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
OW521_16775	COG0081	regulation of translation
OW521_16790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
OW521_16795	COG0222	ribosome binding
OW521_16800	COG0442	prolyl-tRNA aminoacylation
OW521_16805	COG0183	Belongs to the thiolase family
OW521_16810	COG0085	RNA polymerase activity
OW521_16815	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OW521_16820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
OW521_16825	COG0049	tRNA binding
OW521_16830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OW521_16835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OW521_16840	COG2723	6-phospho-beta-galactosidase activity
OW521_16845	COG0051	transcription antitermination factor activity, RNA binding
OW521_16850	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
OW521_16855	COG0088	Forms part of the polypeptide exit tunnel
OW521_16860	COG0089	rRNA binding
OW521_16865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
OW521_16870	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OW521_16875	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
OW521_16880	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OW521_16885	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
OW521_16895	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OW521_16900	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
OW521_16905	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
OW521_16910	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
OW521_16915	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
OW521_16920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OW521_16930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
OW521_16935	COG1841	ribosomal large subunit assembly
OW521_16940	COG0200	Binds to the 23S rRNA
OW521_16950	COG0563	adenylate kinase activity
OW521_16970	COG1175	transmembrane transport
OW521_16975	COG3191	aminopeptidase activity
OW521_16980	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
OW521_16985	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OW521_16990	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OW521_16995	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
OW521_17000	COG0202	RNA polymerase activity
OW521_17005	COG0203	ribosomal protein L17
OW521_17010	COG0101	tRNA pseudouridine synthase activity
OW521_17030	COG2894	cell division
OW521_17065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OW521_17070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OW521_17075	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OW521_17090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OW521_17095	COG1876	peptidase activity
OW521_17100	COG1072	(Pantothenic acid kinase))
OW521_17110	COG0736	holo-[acyl-carrier-protein] synthase activity
OW521_17135	COG0667	Aldo Keto reductase
OW521_17150	COG2759	Belongs to the formate--tetrahydrofolate ligase family
OW521_17155	COG0438	transferase activity, transferring glycosyl groups
OW521_17170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OW521_17175	COG0802	atpase or kinase
OW521_17190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OW521_17195	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
OW521_17200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OW521_17215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
OW521_17220	COG0459	protein refolding
OW521_17225	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
OW521_17225	COG2755	lipolytic protein G-D-S-L family
OW521_17235	COG0516	GMP reductase activity
OW521_17240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
OW521_17260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OW521_17260	COG0519	Catalyzes the synthesis of GMP from XMP
OW521_17285	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OW521_17290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OW521_17330	COG0582	viral genome integration into host DNA
OW521_17450	COG1484	DNA-dependent DNA replication
OW521_17470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OW521_17490	COG4974	Belongs to the 'phage' integrase family
OW521_17510	COG1942	4-Oxalocrotonate Tautomerase
OW521_17515	COG0673	inositol 2-dehydrogenase activity
OW521_17540	COG1172	Belongs to the binding-protein-dependent transport system permease family
OW521_17545	COG1172	Belongs to the binding-protein-dependent transport system permease family
OW521_17555	COG1609	Transcriptional regulator
OW521_17575	COG0667	Aldo Keto reductase
OW521_17605	COG3962	Belongs to the TPP enzyme family
OW521_17620	COG0673	inositol 2-dehydrogenase activity
OW521_17625	COG1082	Xylose isomerase domain protein TIM barrel
OW521_17630	COG2188	Transcriptional regulator
OW521_17635	COG2814	Major facilitator Superfamily
OW521_17645	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
OW521_17660	COG0667	Aldo Keto reductase
OW521_17685	COG2159	amidohydrolase
OW521_17715	COG0477	Major facilitator Superfamily
OW521_17720	COG1053	succinate dehydrogenase
OW521_17725	COG1063	alcohol dehydrogenase
OW521_17735	COG0583	DNA-binding transcription factor activity
OW521_17740	COG1053	succinate dehydrogenase
OW521_17745	COG0583	DNA-binding transcription factor activity
OW521_17750	COG0477	Major facilitator Superfamily
OW521_17755	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OW521_17760	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_17775	COG0656	L-ascorbic acid biosynthetic process
OW521_17780	COG1053	succinate dehydrogenase
OW521_17785	COG2807	transmembrane transport
OW521_17790	COG0477	Major facilitator Superfamily
OW521_17800	COG1414	Transcriptional regulator
OW521_17810	COG0583	DNA-binding transcription factor activity
OW521_17830	COG4172	Belongs to the ABC transporter superfamily
OW521_17860	COG2814	Major facilitator Superfamily
OW521_17895	COG1473	amidohydrolase
OW521_17915	COG0154	amidase activity
OW521_17990	COG1484	DNA-dependent DNA replication
OW521_18000	COG2086	electron transfer activity
OW521_18005	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OW521_18010	COG2186	Transcriptional regulator
OW521_18015	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_18055	COG0318	PFAM AMP-dependent synthetase and ligase
OW521_18060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_18065	COG1960	acyl-CoA dehydrogenase activity
OW521_18070	COG2267	carboxylic ester hydrolase activity
OW521_18080	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
OW521_18095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OW521_18100	COG1960	acyl-CoA dehydrogenase activity
OW521_18125	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_18130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_18140	COG1024	Enoyl-CoA hydratase
OW521_18165	COG0477	Major facilitator Superfamily
OW521_18180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OW521_18190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OW521_18200	COG1869	D-ribose catabolic process
OW521_18210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OW521_18225	COG1129	ABC transporter
OW521_18230	COG1172	Belongs to the binding-protein-dependent transport system permease family
OW521_18240	COG2376	Dihydroxyacetone kinase
OW521_18245	COG0698	ribose 5-phosphate isomerase
OW521_18250	COG0149	triose-phosphate isomerase activity
OW521_18255	COG1349	DNA-binding transcription factor activity
OW521_18260	COG1063	alcohol dehydrogenase
OW521_18285	COG1609	Transcriptional regulator
OW521_18295	COG1175	transmembrane transport
OW521_18300	COG0395	ABC-type sugar transport system, permease component
OW521_18310	COG0673	inositol 2-dehydrogenase activity
OW521_18335	COG0673	inositol 2-dehydrogenase activity
OW521_18340	COG1609	Transcriptional regulator
OW521_18345	COG1904	glucuronate isomerase
OW521_18350	COG0246	Mannitol dehydrogenase
OW521_18355	COG4948	Mandelate Racemase Muconate Lactonizing
OW521_18380	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OW521_18385	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OW521_18395	COG5006	permease, DMT superfamily
OW521_18445	COG0626	cystathionine gamma-synthase activity
OW521_18450	COG2814	Major facilitator Superfamily
OW521_18455	COG0583	DNA-binding transcription factor activity
OW521_18460	COG2971	BadF BadG BcrA BcrD
OW521_18485	COG1174	glycine betaine transport
OW521_18490	COG1174	glycine betaine transport
OW521_18505	COG2326	polyphosphate kinase activity
OW521_18510	COG1722	exodeoxyribonuclease VII activity
OW521_18515	COG1570	exodeoxyribonuclease VII activity
OW521_18525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
OW521_18535	COG0012	GTP binding
OW521_18540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OW521_18550	COG4166	transmembrane transport
OW521_18555	COG0601	transmembrane transport
OW521_18580	COG0601	transmembrane transport
OW521_18585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OW521_18595	COG1217	gtp-binding protein TYPA
OW521_18635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OW521_18640	COG3226	Transcriptional regulator
OW521_18655	COG2171	N-acyltransferase activity
OW521_18660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OW521_18665	COG0765	amino acid transport
OW521_18670	COG0765	amino acid transport
OW521_18675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OW521_18680	COG1126	abc transporter atp-binding protein
OW521_18710	COG1595	DNA-templated transcription, initiation
OW521_18720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OW521_18735	COG2239	Acts as a magnesium transporter
OW521_18745	COG0006	proline dipeptidase activity
OW521_18750	COG0613	PHP domain protein
OW521_18755	COG2189	Belongs to the N(4) N(6)-methyltransferase family
OW521_18760	COG0513	Belongs to the DEAD box helicase family
OW521_18765	COG0557	exoribonuclease II activity
OW521_18770	COG0352	thiamine-phosphate diphosphorylase activity
OW521_18775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OW521_18775	COG2022	thiamine diphosphate biosynthetic process
OW521_18785	COG2022	thiamine diphosphate biosynthetic process
OW521_18790	COG2154	pterin-4-alpha-carbinolamine dehydratase
OW521_18805	COG1309	transcriptional regulator
OW521_18820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
OW521_18825	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
OW521_18835	COG3253	May function as heme-dependent peroxidase
OW521_18840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OW521_18845	COG0181	hydroxymethylbilane synthase activity
OW521_18855	COG0113	porphobilinogen synthase activity
OW521_18865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OW521_18870	COG1472	Belongs to the glycosyl hydrolase 3 family
OW521_18875	COG1126	abc transporter atp-binding protein
OW521_18880	COG0765	amino acid transport
OW521_18885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OW521_18905	COG0210	DNA helicase
OW521_18915	COG2816	NAD+ diphosphatase activity
OW521_18935	COG3480	Lon protease (S16) C-terminal proteolytic domain
OW521_18940	COG1615	UPF0182 protein
OW521_18965	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OW521_18975	COG1960	acyl-CoA dehydrogenase activity
OW521_18980	COG1842	Phage shock protein A
OW521_18990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OW521_18995	COG2086	electron transfer activity
OW521_19000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OW521_19010	COG3265	gluconokinase activity
OW521_19035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OW521_19040	COG0484	heat shock protein binding
OW521_19070	COG0482	sulfurtransferase activity
OW521_19090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OW521_19125	COG0714	Associated with various cellular activities
OW521_19150	COG5000	phosphorelay sensor kinase activity
OW521_19150	COG5002	protein histidine kinase activity
OW521_19155	COG5401	PFAM Sporulation and spore germination
OW521_19165	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
OW521_19170	COG3214	Protein conserved in bacteria
OW521_19175	COG0653	protein targeting
OW521_19210	COG2902	Dehydrogenase
OW521_19235	COG1674	ftsk spoiiie
OW521_19235	COG0433	COG0433 Predicted ATPase
OW521_19245	COG1216	Glycosyl transferase, family 2
OW521_19275	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
OW521_19335	COG1088	dTDP-glucose 4,6-dehydratase activity
OW521_19350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OW521_19395	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
OW521_19400	COG2884	Cell division ATP-binding protein ftsE
OW521_19405	COG2177	Part of the ABC transporter FtsEX involved in
OW521_19415	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OW521_19460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OW521_19465	COG0483	inositol monophosphate 1-phosphatase activity
OW521_19475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OW521_19485	COG1595	DNA-templated transcription, initiation
OW521_19515	COG1253	flavin adenine dinucleotide binding
OW521_19530	COG1121	(ABC) transporter
OW521_19535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OW521_19560	COG1064	alcohol dehydrogenase
OW521_19570	COG1643	Atp-dependent helicase
OW521_19630	COG0018	arginyl-trna synthetase
OW521_19635	COG0019	diaminopimelate decarboxylase activity
OW521_19640	COG0460	homoserine dehydrogenase
OW521_19645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OW521_19650	COG0083	homoserine kinase activity
OW521_19660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
OW521_19665	COG2890	protein-(glutamine-N5) methyltransferase activity
OW521_19680	COG1216	Glycosyl transferase, family 2
OW521_19700	COG0356	it plays a direct role in the translocation of protons across the membrane
OW521_19705	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OW521_19710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OW521_19715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OW521_19720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OW521_19725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
OW521_19730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OW521_19735	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OW521_19745	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
OW521_19750	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
OW521_19760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OW521_19765	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
OW521_19780	COG0628	permease
OW521_19795	COG1902	pentaerythritol trinitrate reductase activity
OW521_19810	COG0363	glucosamine-6-phosphate deaminase activity
OW521_19825	COG1335	isochorismatase
OW521_19835	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
OW521_19845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OW521_19850	COG1234	tRNA 3'-trailer cleavage
OW521_19855	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
OW521_19860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OW521_19895	COG2149	membrane
OW521_19905	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OW521_19915	COG0419	ATPase involved in DNA repair
OW521_19925	COG1414	Transcriptional regulator
OW521_19955	COG0508	dehydrogenase complex catalyzes the overall conversion of
OW521_19960	COG0022	dehydrogenase e1 component
OW521_19970	COG1113	amino acid transport
OW521_19985	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
OW521_19990	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
OW521_20000	COG1104	cysteine desulfurase activity
OW521_20010	COG0179	Fumarylacetoacetate (FAA) hydrolase
OW521_20025	COG1305	Transglutaminase-like
OW521_20035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OW521_20040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OW521_20045	COG0579	oxidoreductase
OW521_20050	COG0747	negative chemotaxis
OW521_20080	COG2133	pyrroloquinoline quinone binding
OW521_20105	COG0440	acetolactate synthase activity
OW521_20110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
OW521_20115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OW521_20125	COG0577	efflux transmembrane transporter activity
OW521_20125	COG1136	(ABC) transporter
OW521_20145	COG0473	3-isopropylmalate dehydrogenase activity
OW521_20150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OW521_20160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OW521_20165	COG0179	Fumarylacetoacetate (FAA) hydrolase
OW521_20170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OW521_20175	COG0546	phosphoglycolate phosphatase activity
OW521_20200	COG1414	Transcriptional regulator
OW521_20205	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
OW521_20210	COG0066	3-isopropylmalate dehydratase activity
OW521_20215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OW521_20225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
OW521_20230	COG1181	Belongs to the D-alanine--D-alanine ligase family
OW521_20260	COG0742	ribosomal rna small subunit methyltransferase
OW521_20275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
OW521_20285	COG0333	Belongs to the bacterial ribosomal protein bL32 family
OW521_20290	COG0571	ribonuclease III activity
OW521_20295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OW521_20315	COG2814	Major facilitator Superfamily
OW521_20330	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OW521_20355	COG2514	catechol 2,3-dioxygenase activity
OW521_20365	COG0228	four-way junction DNA binding
OW521_20370	COG1837	Belongs to the UPF0109 family
OW521_20375	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OW521_20380	COG0336	Belongs to the RNA methyltransferase TrmD family
OW521_20385	COG0335	large ribosomal subunit rRNA binding
OW521_20390	COG0681	Belongs to the peptidase S26 family
OW521_20400	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OW521_20410	COG0792	nuclease activity
OW521_20425	COG4974	Belongs to the 'phage' integrase family
OW521_20440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OW521_20445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OW521_20460	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
OW521_20495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OW521_20500	COG3842	ATPase activity
OW521_20520	COG2188	Transcriptional regulator
OW521_20530	COG1414	Transcriptional regulator
OW521_20535	COG0477	Major facilitator Superfamily
OW521_20545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OW521_20550	COG2084	Dehydrogenase
OW521_20555	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_20560	COG1063	alcohol dehydrogenase
OW521_20570	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
OW521_20575	COG0300	oxidoreductase activity
OW521_20580	COG1045	serine acetyltransferase
OW521_20590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OW521_20595	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OW521_20605	COG3022	response to hydroperoxide
OW521_20635	COG0242	peptide deformylase activity
OW521_20675	COG0024	Methionine aminopeptidase
OW521_20690	COG0629	single-stranded DNA binding
OW521_20705	COG1946	Acyl-CoA thioesterase
OW521_20720	COG0668	transmembrane transport
OW521_20760	COG0544	peptidyl-prolyl cis-trans isomerase activity
OW521_20765	COG0740	serine-type endopeptidase activity
OW521_20770	COG0740	serine-type endopeptidase activity
OW521_20775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
OW521_20780	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OW521_20785	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OW521_20790	COG0525	valine-tRNA ligase activity
OW521_20795	COG3189	MarR family transcriptional regulator
OW521_20810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OW521_20815	COG0285	dihydrofolate synthase activity
OW521_20825	COG0105	UTP biosynthetic process
OW521_20835	COG1530	ribonuclease E activity
OW521_20840	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OW521_20840	COG0351	phosphomethylpyrimidine kinase
OW521_20840	COG0352	thiamine-phosphate diphosphorylase activity
OW521_20845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
OW521_20850	COG0211	Belongs to the bacterial ribosomal protein bL27 family
OW521_20855	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OW521_20860	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OW521_20865	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OW521_20875	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OW521_20885	COG0799	negative regulation of ribosome biogenesis
OW521_20895	COG1609	Transcriptional regulator
OW521_20905	COG0587	DNA-directed DNA polymerase activity
OW521_20940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OW521_20945	COG0154	amidase activity
OW521_20950	COG2957	Belongs to the agmatine deiminase family
OW521_20960	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_20965	COG1309	transcriptional regulator
OW521_21000	COG2813	Specifically methylates the guanine in position
OW521_21015	COG2182	Extracellular solute-binding protein
OW521_21020	COG1175	transmembrane transport
OW521_21035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OW521_21040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OW521_21050	COG0583	DNA-binding transcription factor activity
OW521_21060	COG1780	Probably involved in ribonucleotide reductase function
OW521_21065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OW521_21070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OW521_21085	COG1234	tRNA 3'-trailer cleavage
OW521_21090	COG0412	Dienelactone hydrolase
OW521_21135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OW521_21160	COG2814	Major facilitator Superfamily
OW521_21175	COG3415	Transposase
OW521_21175	COG2801	Transposase and inactivated derivatives
OW521_21180	COG0492	ferredoxin-NADP+ reductase activity
OW521_21185	COG0456	acetyltransferase
OW521_21190	COG0494	nUDIX hydrolase
OW521_21195	COG1349	DNA-binding transcription factor activity
OW521_21205	COG1064	alcohol dehydrogenase
OW521_21240	COG1643	Atp-dependent helicase
OW521_21260	COG0009	L-threonylcarbamoyladenylate synthase
OW521_21290	COG3483	tryptophan 2,3-dioxygenase activity
OW521_21320	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
OW521_21325	COG2050	protein possibly involved in aromatic compounds catabolism
OW521_21335	COG4552	Acetyltransferase involved in intracellular survival and related
OW521_21345	COG0539	negative regulation of cytoplasmic translation
OW521_21350	COG1739	Uncharacterized protein family UPF0029
OW521_21355	COG0237	dephospho-CoA kinase activity
OW521_21355	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
OW521_21360	COG0556	nucleotide-excision repair
OW521_21390	COG4106	trans-aconitate 2-methyltransferase activity
OW521_21415	COG0546	phosphoglycolate phosphatase activity
OW521_21425	COG0322	excinuclease ABC activity
OW521_21435	COG0391	Required for morphogenesis under gluconeogenic growth conditions
OW521_21440	COG1481	regulation of sporulation
OW521_21445	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OW521_21450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OW521_21455	COG0126	phosphoglycerate kinase activity
OW521_21460	COG0149	triose-phosphate isomerase activity
OW521_21465	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OW521_21475	COG0363	glucosamine-6-phosphate deaminase activity
OW521_21490	COG0166	Belongs to the GPI family
OW521_21495	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OW521_21505	COG0109	protoheme IX farnesyltransferase activity
OW521_21510	COG1612	heme a metabolic process
OW521_21520	COG1131	(ABC) transporter
OW521_21545	COG0396	ATPase activity
OW521_21550	COG2151	metal-sulfur cluster biosynthetic enzyme
OW521_21570	COG1122	ATPase activity
OW521_21575	COG1268	BioY protein
OW521_21585	COG0488	(ABC) transporter
OW521_21615	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_21620	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_21625	COG0560	Phosphoserine phosphatase
OW521_21625	COG3830	Belongs to the UPF0237 family
OW521_21630	COG1119	ATPase activity
OW521_21645	COG0254	rRNA binding
OW521_21670	COG2855	membrane
OW521_21695	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
OW521_21700	COG0297	glycogen (starch) synthase activity
OW521_21720	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_21740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OW521_21760	COG0656	L-ascorbic acid biosynthetic process
OW521_21765	COG1968	undecaprenyl-diphosphatase activity
OW521_21770	COG0215	cysteine-tRNA ligase activity
OW521_21780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OW521_21785	COG1994	Peptidase M50
OW521_21785	COG0517	IMP dehydrogenase activity
OW521_21795	COG1222	aaa ATPase
OW521_21800	COG4122	O-methyltransferase activity
OW521_21810	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
OW521_21815	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
OW521_21820	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
OW521_21825	COG0545	Peptidyl-prolyl cis-trans isomerase
OW521_21845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OW521_21850	COG0805	protein transport
OW521_21855	COG4581	dead DEAH box helicase
OW521_21860	COG1574	metal-dependent hydrolase with the TIM-barrel fold
OW521_21865	COG1216	Glycosyl transferase, family 2
OW521_21895	COG0242	peptide deformylase activity
OW521_21910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OW521_21915	COG3424	synthase
OW521_21925	COG4974	Belongs to the 'phage' integrase family
OW521_21975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OW521_21990	COG1280	lysine exporter protein (LysE YggA)
OW521_21995	COG1316	TRANSCRIPTIONal
OW521_22000	COG2755	lipolytic protein G-D-S-L family
OW521_22010	COG1280	lysine exporter protein (LysE YggA)
OW521_22030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OW521_22035	COG1845	cytochrome c oxidase, subunit III
OW521_22040	COG2010	Cytochrome c
OW521_22045	COG0723	plastoquinol--plastocyanin reductase activity
OW521_22050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
OW521_22055	COG2188	Transcriptional regulator
OW521_22060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OW521_22070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OW521_22075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OW521_22095	COG0167	dihydroorotate dehydrogenase activity
OW521_22110	COG2267	carboxylic ester hydrolase activity
OW521_22115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OW521_22120	COG1381	Involved in DNA repair and RecF pathway recombination
OW521_22125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OW521_22130	COG3590	peptidase
OW521_22135	COG1316	TRANSCRIPTIONal
OW521_22140	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OW521_22150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
OW521_22170	COG0484	heat shock protein binding
OW521_22175	COG1420	regulation of RNA biosynthetic process
OW521_22195	COG0481	GTPase activity
OW521_22205	COG0268	Binds directly to 16S ribosomal RNA
OW521_22240	COG1307	EDD domain protein, DegV family
OW521_22245	COG0495	leucyl-tRNA aminoacylation
OW521_22250	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OW521_22255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OW521_22260	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
OW521_22265	COG2390	Transcriptional regulator
OW521_22270	COG0656	L-ascorbic acid biosynthetic process
OW521_22280	COG0438	transferase activity, transferring glycosyl groups
OW521_22290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OW521_22300	COG1758	RNA polymerase activity
OW521_22305	COG0194	GDP metabolic process
OW521_22310	COG0194	GDP metabolic process
OW521_22315	COG0284	orotidine-5'-phosphate decarboxylase activity
OW521_22320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OW521_22325	COG0505	Belongs to the CarA family
OW521_22335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OW521_22340	COG0540	Belongs to the ATCase OTCase family
OW521_22345	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
OW521_22350	COG0745	RESPONSE REGULATOR receiver
OW521_22355	COG5002	protein histidine kinase activity
OW521_22365	COG0438	transferase activity, transferring glycosyl groups
OW521_22370	COG0438	transferase activity, transferring glycosyl groups
OW521_22375	COG1132	(ABC) transporter
OW521_22395	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
OW521_22410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OW521_22415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OW521_22425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
OW521_22430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OW521_22435	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
OW521_22440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OW521_22455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OW521_22470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
OW521_22495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OW521_22500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OW521_22525	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
OW521_22540	COG1196	nuclear chromosome segregation
OW521_22550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OW521_22555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OW521_22560	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OW521_22570	COG2255	four-way junction helicase activity
OW521_22575	COG0632	four-way junction helicase activity
OW521_22580	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
OW521_22585	COG0217	transcriptional regulatory protein
OW521_22590	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
OW521_22615	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
OW521_22625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OW521_22635	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
OW521_22660	COG0076	glutamate decarboxylase activity
OW521_22725	COG0405	Gamma-glutamyltransferase
OW521_22730	COG1609	Transcriptional regulator
OW521_22735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OW521_22740	COG4948	Mandelate Racemase Muconate Lactonizing
OW521_22745	COG0246	Mannitol dehydrogenase
OW521_22750	COG1063	alcohol dehydrogenase
OW521_22755	COG0477	Major facilitator Superfamily
OW521_22760	COG0800	Aldolase
OW521_22780	COG0515	serine threonine protein kinase
OW521_22790	COG3422	double-strand break repair
OW521_22800	COG0477	Major facilitator Superfamily
OW521_22805	COG1396	sequence-specific DNA binding
OW521_22815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_22820	COG1024	Enoyl-CoA hydratase
OW521_22825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OW521_22835	COG1012	belongs to the aldehyde dehydrogenase family
OW521_22885	COG2814	Major facilitator Superfamily
OW521_22910	COG3226	Transcriptional regulator
OW521_22930	COG1012	belongs to the aldehyde dehydrogenase family
OW521_22950	COG3387	PFAM Glycoside hydrolase 15-related
OW521_22975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OW521_23015	COG5434	Belongs to the glycosyl hydrolase 28 family
OW521_23015	COG4632	Exopolysaccharide biosynthesis protein
OW521_23030	COG0318	PFAM AMP-dependent synthetase and ligase
OW521_23035	COG0438	transferase activity, transferring glycosyl groups
OW521_23080	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
OW521_23140	COG0789	Transcriptional regulator
OW521_23145	COG3118	belongs to the thioredoxin family
OW521_23155	COG0667	Aldo Keto reductase
OW521_23160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OW521_23170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
OW521_23175	COG0633	Ferredoxin
OW521_23175	COG0543	2 iron, 2 sulfur cluster binding
OW521_23190	COG0667	Aldo Keto reductase
OW521_23195	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
OW521_23250	COG0477	Major facilitator Superfamily
OW521_23260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OW521_23270	COG0154	amidase activity
OW521_23275	COG0154	amidase activity
OW521_23280	COG1802	Transcriptional regulator
OW521_23285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_23290	COG1024	Enoyl-CoA hydratase
OW521_23300	COG1129	ABC transporter
OW521_23305	COG1879	ABC-type sugar transport system periplasmic component
OW521_23315	COG0450	alkyl hydroperoxide reductase
OW521_23355	COG3511	phospholipase C
OW521_23410	COG0667	Aldo Keto reductase
OW521_23435	COG0667	Aldo Keto reductase
OW521_23470	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
OW521_23495	COG0473	3-isopropylmalate dehydrogenase activity
OW521_23505	COG1802	Transcriptional regulator
OW521_23515	COG4152	abc transporter atp-binding protein
OW521_23540	COG1609	Transcriptional regulator
OW521_23555	COG0640	Transcriptional regulator
OW521_23560	COG0477	Major facilitator Superfamily
OW521_23575	COG2902	Dehydrogenase
OW521_23600	COG1175	transmembrane transport
OW521_23640	COG1073	alpha beta
OW521_23645	COG0747	negative chemotaxis
OW521_23670	COG1940	carbohydrate kinase activity
OW521_23675	COG1082	Xylose isomerase domain protein TIM barrel
OW521_23680	COG0673	inositol 2-dehydrogenase activity
OW521_23685	COG1609	Transcriptional regulator
OW521_23690	COG1940	carbohydrate kinase activity
OW521_23695	COG0673	inositol 2-dehydrogenase activity
OW521_23715	COG0444	Belongs to the ABC transporter superfamily
OW521_23750	COG4638	Rieske (2fe-2S)
OW521_23760	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_23765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OW521_23770	COG3250	beta-galactosidase activity
OW521_23785	COG0154	amidase activity
OW521_23815	COG4948	Mandelate Racemase Muconate Lactonizing
OW521_23820	COG4829	muconolactone delta-isomerase
OW521_23825	COG3485	protocatechuate 3,4-dioxygenase
OW521_23835	COG3250	beta-galactosidase activity
OW521_23845	COG1846	Transcriptional regulator
OW521_23860	COG3119	arylsulfatase activity
OW521_23865	COG3119	arylsulfatase activity
OW521_24025	COG1793	dna ligase
OW521_24035	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs