locus-tag	class	description
MN0502_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MN0502_00020	COG0592	DNA-directed DNA polymerase activity
MN0502_00030	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MN0502_00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MN0502_00050	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
MN0502_00060	COG0187	DNA topoisomerase II activity
MN0502_00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MN0502_00080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MN0502_00090	COG3266	domain, Protein
MN0502_00130	COG0705	Rhomboid family
MN0502_00140	COG1482	cell wall glycoprotein biosynthetic process
MN0502_00170	COG2815	serine threonine protein kinase
MN0502_00170	COG0515	serine threonine protein kinase
MN0502_00180	COG0515	serine threonine protein kinase
MN0502_00190	COG0768	penicillin binding
MN0502_00220	COG1716	ATPase activity
MN0502_00230	COG1716	ATPase activity
MN0502_00240	COG0587	DNA-directed DNA polymerase activity
MN0502_00290	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_00320	COG0783	Belongs to the Dps family
MN0502_00360	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_00370	COG0071	Belongs to the small heat shock protein (HSP20) family
MN0502_00410	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MN0502_00450	COG2186	Transcriptional regulator
MN0502_00470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MN0502_00510	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MN0502_00520	COG0400	carboxylic ester hydrolase activity
MN0502_00530	COG0346	lactoylglutathione lyase activity
MN0502_00570	COG0561	phosphatase activity
MN0502_00610	COG2233	PERMEase
MN0502_00630	COG1012	belongs to the aldehyde dehydrogenase family
MN0502_00660	COG1929	Belongs to the glycerate kinase type-1 family
MN0502_00670	COG0318	PFAM AMP-dependent synthetase and ligase
MN0502_00680	COG3104	oligopeptide transport
MN0502_00690	COG3104	oligopeptide transport
MN0502_00740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MN0502_00750	COG0077	Prephenate dehydratase
MN0502_00790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MN0502_00800	COG0561	phosphatase activity
MN0502_00820	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MN0502_00850	COG0037	tRNA processing
MN0502_00870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MN0502_00880	COG0302	gtp cyclohydrolase
MN0502_00900	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MN0502_00970	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MN0502_00980	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MN0502_00990	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MN0502_01010	COG0542	response to heat
MN0502_01030	COG0823	Involved in the tonB-independent uptake of proteins
MN0502_01030	COG1506	peptidase
MN0502_01040	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MN0502_01050	COG3237	CsbD-like
MN0502_01060	COG2376	Dihydroxyacetone kinase
MN0502_01070	COG1461	Dihydroxyacetone kinase
MN0502_01110	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MN0502_01180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MN0502_01190	COG0306	phosphate transporter
MN0502_01280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MN0502_01290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MN0502_01290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MN0502_01290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MN0502_01310	COG1349	DNA-binding transcription factor activity
MN0502_01320	COG2261	transglycosylase associated protein
MN0502_01340	COG2733	membrane
MN0502_01360	COG3387	PFAM Glycoside hydrolase 15-related
MN0502_01410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MN0502_01420	COG0280	phosphate acetyltransferase
MN0502_01420	COG0857	belongs to the CobB CobQ family
MN0502_01490	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_01580	COG1120	ATPase activity
MN0502_01660	COG1309	transcriptional regulator
MN0502_01700	COG0833	amino acid
MN0502_01720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MN0502_01790	COG0395	ABC-type sugar transport system, permease component
MN0502_02070	COG2135	peptidase activity
MN0502_02200	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MN0502_02210	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MN0502_02220	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MN0502_02250	COG3546	catalase activity
MN0502_02340	COG2409	Drug exporters of the RND superfamily
MN0502_02360	COG1609	Transcriptional regulator
MN0502_02370	COG1063	alcohol dehydrogenase
MN0502_02400	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MN0502_02460	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MN0502_02540	COG0702	epimerase
MN0502_02650	COG2197	response regulator
MN0502_02660	COG4585	Histidine kinase
MN0502_02670	COG2409	Drug exporters of the RND superfamily
MN0502_02690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MN0502_02750	COG0861	Integral membrane protein TerC family
MN0502_02790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MN0502_02800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MN0502_02810	COG1414	Transcriptional regulator
MN0502_02840	COG3979	chitinase
MN0502_02880	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MN0502_02900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MN0502_02940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MN0502_02960	COG3291	Pkd domain containing protein
MN0502_02960	COG4412	M6 family metalloprotease domain protein
MN0502_02990	COG1063	alcohol dehydrogenase
MN0502_03020	COG0702	epimerase
MN0502_03040	COG0673	inositol 2-dehydrogenase activity
MN0502_03060	COG1072	(Pantothenic acid kinase))
MN0502_03090	COG1473	amidohydrolase
MN0502_03130	COG0438	transferase activity, transferring glycosyl groups
MN0502_03160	COG1607	acyl-coa hydrolase
MN0502_03180	COG1063	alcohol dehydrogenase
MN0502_03190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MN0502_03200	COG2814	Major facilitator Superfamily
MN0502_03240	COG3401	FG-GAP repeat protein
MN0502_03310	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_03320	COG2252	PERMEase
MN0502_03430	COG1653	transport
MN0502_03440	COG1175	transmembrane transport
MN0502_03450	COG0395	ABC-type sugar transport system, permease component
MN0502_03460	COG1609	Transcriptional regulator
MN0502_03530	COG0395	ABC-type sugar transport system, permease component
MN0502_03570	COG0673	inositol 2-dehydrogenase activity
MN0502_03610	COG1172	Belongs to the binding-protein-dependent transport system permease family
MN0502_03620	COG1129	ABC transporter
MN0502_03640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MN0502_03680	COG0191	fructose-bisphosphate aldolase activity
MN0502_03720	COG3655	Transcriptional regulator
MN0502_03750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MN0502_03780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MN0502_03790	COG1609	Transcriptional regulator
MN0502_03820	COG2160	L-arabinose isomerase activity
MN0502_03830	COG4213	ABC transporter substrate-binding protein
MN0502_03850	COG4214	carbohydrate transport
MN0502_03870	COG1832	CoA-binding protein
MN0502_03920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MN0502_03930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MN0502_03950	COG1116	anion transmembrane transporter activity
MN0502_03960	COG1832	CoA-binding protein
MN0502_04020	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MN0502_04030	COG0047	phosphoribosylformylglycinamidine synthase activity
MN0502_04080	COG1404	Belongs to the peptidase S8 family
MN0502_04100	COG4555	ABC transporter
MN0502_04120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MN0502_04140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MN0502_04160	COG0386	Belongs to the glutathione peroxidase family
MN0502_04180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MN0502_04220	COG0351	phosphomethylpyrimidine kinase
MN0502_04240	COG1309	transcriptional regulator
MN0502_04250	COG0343	queuine tRNA-ribosyltransferase activity
MN0502_04320	COG1960	acyl-CoA dehydrogenase activity
MN0502_04330	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MN0502_04370	COG0564	pseudouridine synthase activity
MN0502_04380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MN0502_04390	COG1201	RNA secondary structure unwinding
MN0502_04410	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MN0502_04430	COG2226	methyltransferase
MN0502_04480	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MN0502_04530	COG0590	tRNA wobble adenosine to inosine editing
MN0502_04540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MN0502_04550	COG0531	amino acid
MN0502_04590	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MN0502_04620	COG1505	serine-type exopeptidase activity
MN0502_04700	COG1966	Carbon starvation protein
MN0502_04740	COG4585	Histidine kinase
MN0502_04750	COG2197	response regulator
MN0502_04800	COG0656	L-ascorbic acid biosynthetic process
MN0502_04830	COG1256	bacterial-type flagellum assembly
MN0502_04830	COG4786	Flagellar basal body rod
MN0502_04840	COG1256	bacterial-type flagellum assembly
MN0502_04840	COG4786	Flagellar basal body rod
MN0502_04860	COG5001	Diguanylate cyclase
MN0502_04860	COG3300	MHYT domain
MN0502_04870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MN0502_04910	COG1815	bacterial-type flagellum-dependent cell motility
MN0502_04920	COG1558	bacterial-type flagellum-dependent cell motility
MN0502_04930	COG1677	Flagellar hook-basal body complex protein FliE
MN0502_04950	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MN0502_04970	COG1157	protein secretion by the type III secretion system
MN0502_04990	COG0791	NLP P60 protein
MN0502_04990	COG3883	PFAM NLP P60 protein
MN0502_05010	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MN0502_05070	COG1360	Flagellar Motor Protein
MN0502_05090	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MN0502_05090	COG1776	CheC inhibitor of MCP methylation
MN0502_05110	COG1338	Plays a role in the flagellum-specific transport system
MN0502_05120	COG1987	bacterial-type flagellum assembly
MN0502_05140	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MN0502_05150	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MN0502_05190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MN0502_05200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MN0502_05240	COG0588	phosphoglycerate mutase activity
MN0502_05250	COG0704	Plays a role in the regulation of phosphate uptake
MN0502_05260	COG5002	protein histidine kinase activity
MN0502_05300	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MN0502_05310	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MN0502_05320	COG0215	cysteine-tRNA ligase activity
MN0502_05370	COG0366	Alpha amylase catalytic
MN0502_05380	COG0366	Alpha amylase catalytic
MN0502_05390	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MN0502_05410	COG0277	FAD linked oxidase domain protein
MN0502_05440	COG3842	ATPase activity
MN0502_05450	COG1877	trehalose-phosphatase activity
MN0502_05480	COG1162	GTPase activity
MN0502_05490	COG1162	GTPase activity
MN0502_05510	COG2814	Major facilitator Superfamily
MN0502_05550	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_05570	COG0753	catalase activity
MN0502_05580	COG0028	Belongs to the TPP enzyme family
MN0502_05630	COG1902	pentaerythritol trinitrate reductase activity
MN0502_05640	COG0477	Major facilitator Superfamily
MN0502_05660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MN0502_05670	COG0667	Aldo Keto reductase
MN0502_05720	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MN0502_05760	COG0459	protein refolding
MN0502_05780	COG2205	protein histidine kinase activity
MN0502_05790	COG0745	RESPONSE REGULATOR receiver
MN0502_05800	COG1061	Type III restriction enzyme res subunit
MN0502_05870	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MN0502_05960	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MN0502_05970	COG1126	abc transporter atp-binding protein
MN0502_05980	COG0765	amino acid transport
MN0502_05990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MN0502_06000	COG1132	(ABC) transporter
MN0502_06040	COG0045	succinate-CoA ligase (ADP-forming) activity
MN0502_06060	COG2814	Major facilitator Superfamily
MN0502_06100	COG0318	PFAM AMP-dependent synthetase and ligase
MN0502_06130	COG1396	sequence-specific DNA binding
MN0502_06160	COG0028	Belongs to the TPP enzyme family
MN0502_06190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MN0502_06210	COG3424	synthase
MN0502_06220	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_06240	COG1652	LysM domain
MN0502_06250	COG1063	alcohol dehydrogenase
MN0502_06260	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_06290	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MN0502_06300	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MN0502_06310	COG1802	Transcriptional regulator
MN0502_06350	COG1122	ATPase activity
MN0502_06370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MN0502_06390	COG3135	benzoate transporter
MN0502_06420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MN0502_06430	COG1278	Cold shock
MN0502_06480	COG0395	ABC-type sugar transport system, permease component
MN0502_06490	COG1175	transmembrane transport
MN0502_06500	COG1653	transport
MN0502_06510	COG1609	Transcriptional regulator
MN0502_06530	COG3250	beta-galactosidase activity
MN0502_06610	COG0737	Belongs to the 5'-nucleotidase family
MN0502_06630	COG5416	Lipopolysaccharide assembly protein A domain
MN0502_06650	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MN0502_06660	COG0596	Alpha beta hydrolase
MN0502_06660	COG0508	dehydrogenase complex catalyzes the overall conversion of
MN0502_06680	COG2072	flavoprotein involved in K transport
MN0502_06700	COG1609	Transcriptional regulator
MN0502_06730	COG2814	Major facilitator Superfamily
MN0502_06760	COG0477	Major facilitator Superfamily
MN0502_06810	COG1501	Belongs to the glycosyl hydrolase 31 family
MN0502_06820	COG1501	Belongs to the glycosyl hydrolase 31 family
MN0502_06860	COG1595	DNA-templated transcription, initiation
MN0502_06900	COG2267	carboxylic ester hydrolase activity
MN0502_06940	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_06960	COG0702	epimerase
MN0502_07010	COG1802	Transcriptional regulator
MN0502_07100	COG4702	Belongs to the UPF0303 family
MN0502_07110	COG2610	gluconate transmembrane transporter activity
MN0502_07120	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MN0502_07190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MN0502_07250	COG1368	sulfuric ester hydrolase activity
MN0502_07560	COG2226	methyltransferase
MN0502_07560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MN0502_07560	COG0596	Alpha beta hydrolase
MN0502_07600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MN0502_07620	COG2376	Dihydroxyacetone kinase
MN0502_07680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MN0502_07690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MN0502_07700	COG0477	Major facilitator Superfamily
MN0502_07710	COG0477	Major facilitator Superfamily
MN0502_07750	COG0662	Cupin 2, conserved barrel domain protein
MN0502_07770	COG1609	Transcriptional regulator
MN0502_07810	COG1473	amidohydrolase
MN0502_07820	COG0154	amidase activity
MN0502_07860	COG3842	ATPase activity
MN0502_07930	COG2801	Transposase and inactivated derivatives
MN0502_08000	COG0738	Major facilitator superfamily
MN0502_08010	COG3226	Transcriptional regulator
MN0502_08090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MN0502_08100	COG2222	sugar isomerase
MN0502_08110	COG1653	transport
MN0502_08120	COG1175	transmembrane transport
MN0502_08130	COG0395	ABC-type sugar transport system, permease component
MN0502_08150	COG1940	carbohydrate kinase activity
MN0502_08150	COG1846	Transcriptional regulator
MN0502_08190	COG0366	Alpha amylase catalytic
MN0502_08240	COG1215	transferase activity, transferring glycosyl groups
MN0502_08260	COG4565	transcriptional regulatory protein
MN0502_08270	COG3290	protein histidine kinase activity
MN0502_08280	COG3181	Tripartite tricarboxylate transporter family receptor
MN0502_08310	COG0589	response to stress
MN0502_08320	COG0390	transport system, permease component
MN0502_08330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MN0502_08430	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_08440	COG0395	ABC-type sugar transport system, permease component
MN0502_08450	COG1175	transmembrane transport
MN0502_08480	COG0667	Aldo Keto reductase
MN0502_08520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MN0502_08530	COG2066	Belongs to the glutaminase family
MN0502_08530	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MN0502_08540	COG0531	amino acid
MN0502_08570	COG3619	membrane
MN0502_08580	COG0747	negative chemotaxis
MN0502_08610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MN0502_08620	COG0405	Gamma-glutamyltransferase
MN0502_08640	COG1802	Transcriptional regulator
MN0502_08660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MN0502_08680	COG2135	peptidase activity
MN0502_08700	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MN0502_08790	COG0598	Magnesium transport protein CorA
MN0502_08820	COG0477	Major facilitator Superfamily
MN0502_08830	COG0138	bifunctional purine biosynthesis protein purh
MN0502_08840	COG2838	Isocitrate dehydrogenase
MN0502_08860	COG4213	ABC transporter substrate-binding protein
MN0502_08870	COG1172	Belongs to the binding-protein-dependent transport system permease family
MN0502_08930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MN0502_08940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MN0502_08950	COG1131	(ABC) transporter
MN0502_09010	COG0708	Exodeoxyribonuclease III
MN0502_09020	COG0180	Tryptophanyl-tRNA synthetase
MN0502_09050	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MN0502_09080	COG2009	succinate dehydrogenase
MN0502_09100	COG1473	amidohydrolase
MN0502_09100	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MN0502_09190	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MN0502_09200	COG3956	TIGRFAM MazG family protein
MN0502_09210	COG0148	phosphopyruvate hydratase activity
MN0502_09260	COG1252	NADH dehydrogenase
MN0502_09270	COG0683	leucine binding
MN0502_09320	COG0559	Belongs to the binding-protein-dependent transport system permease family
MN0502_09350	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MN0502_09360	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MN0502_09380	COG1349	DNA-binding transcription factor activity
MN0502_09390	COG2017	converts alpha-aldose to the beta-anomer
MN0502_09410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MN0502_09430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MN0502_09450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MN0502_09480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MN0502_09490	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MN0502_09530	COG0477	Major facilitator Superfamily
MN0502_09540	COG1309	transcriptional regulator
MN0502_09560	COG2801	Transposase and inactivated derivatives
MN0502_09570	COG0114	fumarate hydratase activity
MN0502_09620	COG1482	cell wall glycoprotein biosynthetic process
MN0502_09760	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MN0502_09880	COG0714	Associated with various cellular activities
MN0502_09890	COG0084	hydrolase, TatD family'
MN0502_09900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MN0502_09910	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MN0502_09920	COG0488	(ABC) transporter
MN0502_09970	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MN0502_10000	COG0443	Heat shock 70 kDa protein
MN0502_10060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MN0502_10070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MN0502_10090	COG2197	response regulator
MN0502_10120	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MN0502_10130	COG0193	aminoacyl-tRNA hydrolase activity
MN0502_10190	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MN0502_10240	COG4412	M6 family metalloprotease domain protein
MN0502_10240	COG3291	Pkd domain containing protein
MN0502_10340	COG0822	iron-sulfur transferase activity
MN0502_10350	COG5002	protein histidine kinase activity
MN0502_10360	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MN0502_10420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MN0502_10430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MN0502_10470	COG0477	Major facilitator Superfamily
MN0502_10480	COG2815	serine threonine protein kinase
MN0502_10480	COG0515	serine threonine protein kinase
MN0502_10500	COG4770	biotin carboxylase activity
MN0502_10510	COG0424	maF-like protein
MN0502_10570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MN0502_10580	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_10610	COG0631	protein serine/threonine phosphatase activity
MN0502_10630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MN0502_10650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MN0502_10700	COG0789	Transcriptional regulator
MN0502_10710	COG3708	Transcriptional regulator
MN0502_10710	COG2207	Transcriptional regulator
MN0502_10930	COG4221	oxidoreductase activity
MN0502_11090	COG0456	acetyltransferase
MN0502_11100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MN0502_11110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MN0502_11130	COG1063	alcohol dehydrogenase
MN0502_11140	COG0156	8-amino-7-oxononanoate synthase activity
MN0502_11150	COG3012	SEC-C Motif Domain Protein
MN0502_11160	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_11160	COG3321	synthase
MN0502_11160	COG0604	alcohol dehydrogenase
MN0502_11170	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MN0502_11230	COG2986	histidine ammonia-lyase
MN0502_11260	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MN0502_11270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MN0502_11280	COG1228	amidohydrolase
MN0502_11320	COG2873	o-acetylhomoserine
MN0502_11330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MN0502_11390	COG0423	glycine-tRNA ligase activity
MN0502_11460	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MN0502_11480	COG0358	DNA primase activity
MN0502_11490	COG0702	epimerase
MN0502_11500	COG2814	Major facilitator Superfamily
MN0502_11510	COG0477	Major facilitator Superfamily
MN0502_11530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MN0502_11550	COG0297	glycogen (starch) synthase activity
MN0502_11580	COG0052	Belongs to the universal ribosomal protein uS2 family
MN0502_11590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MN0502_11610	COG0528	UMP kinase activity
MN0502_11620	COG0233	cytoplasmic translational termination
MN0502_11650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MN0502_11680	COG3275	phosphorelay sensor kinase activity
MN0502_11700	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MN0502_11710	COG1309	transcriptional regulator
MN0502_11750	COG0022	dehydrogenase e1 component
MN0502_11760	COG0508	dehydrogenase complex catalyzes the overall conversion of
MN0502_11780	COG1309	transcriptional regulator
MN0502_11790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MN0502_11830	COG1960	acyl-CoA dehydrogenase activity
MN0502_11890	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MN0502_11910	COG0750	zinc metalloprotease
MN0502_11950	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MN0502_11960	COG0454	-acetyltransferase
MN0502_11960	COG0456	acetyltransferase
MN0502_11970	COG0442	prolyl-tRNA aminoacylation
MN0502_12010	COG0779	Required for maturation of 30S ribosomal subunits
MN0502_12040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MN0502_12050	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MN0502_12060	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MN0502_12080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MN0502_12130	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MN0502_12140	COG1185	polyribonucleotide nucleotidyltransferase activity
MN0502_12150	COG0612	Peptidase, M16
MN0502_12200	COG0315	cyclic pyranopterin monophosphate synthase activity
MN0502_12230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MN0502_12240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MN0502_12280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MN0502_12290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MN0502_12300	COG1674	ftsk spoiiie
MN0502_12320	COG1546	Belongs to the CinA family
MN0502_12320	COG1058	Belongs to the CinA family
MN0502_12340	COG1396	sequence-specific DNA binding
MN0502_12350	COG1846	Transcriptional regulator
MN0502_12370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MN0502_12380	COG2137	regulation of response to DNA damage stimulus
MN0502_12390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MN0502_12400	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MN0502_12410	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MN0502_12420	COG2813	Specifically methylates the guanine in position
MN0502_12430	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MN0502_12450	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MN0502_12480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MN0502_12490	COG0131	Imidazoleglycerol-phosphate dehydratase
MN0502_12500	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MN0502_12520	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MN0502_12560	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MN0502_12570	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MN0502_12580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MN0502_12590	COG2814	Major facilitator Superfamily
MN0502_12650	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MN0502_12670	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MN0502_12680	COG0072	phenylalanine-tRNA ligase activity
MN0502_12680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MN0502_12700	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MN0502_12710	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MN0502_12720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MN0502_12730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MN0502_12740	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MN0502_12750	COG1438	arginine binding
MN0502_12760	COG0137	argininosuccinate synthase activity
MN0502_12770	COG0165	Argininosuccinate lyase
MN0502_12780	COG1132	(ABC) transporter
MN0502_12790	COG1132	(ABC) transporter
MN0502_12800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MN0502_12800	COG2169	Transcriptional regulator
MN0502_12830	COG2094	Belongs to the DNA glycosylase MPG family
MN0502_12840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MN0502_12860	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MN0502_12880	COG2070	2-Nitropropane dioxygenase
MN0502_12900	COG0647	UMP catabolic process
MN0502_12930	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MN0502_12940	COG0497	DNA recombination
MN0502_12950	COG0504	CTP synthase activity
MN0502_12960	COG0494	nUDIX hydrolase
MN0502_13000	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MN0502_13040	COG4565	transcriptional regulatory protein
MN0502_13060	COG1301	dicarboxylic acid transport
MN0502_13090	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MN0502_13110	COG0287	Prephenate dehydrogenase
MN0502_13120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MN0502_13130	COG1160	GTP binding
MN0502_13140	COG0509	glycine decarboxylation via glycine cleavage system
MN0502_13200	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MN0502_13210	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MN0502_13250	COG1940	carbohydrate kinase activity
MN0502_13270	COG0204	Acyl-transferase
MN0502_13280	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MN0502_13290	COG2815	serine threonine protein kinase
MN0502_13290	COG0515	serine threonine protein kinase
MN0502_13380	COG2001	Belongs to the MraZ family
MN0502_13390	COG0275	rRNA processing
MN0502_13410	COG0768	penicillin binding
MN0502_13420	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MN0502_13440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MN0502_13450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MN0502_13470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MN0502_13500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MN0502_13510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MN0502_13530	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MN0502_13550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MN0502_13560	COG1799	cell septum assembly
MN0502_13580	COG3599	regulation of cell shape
MN0502_13590	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MN0502_13610	COG0587	DNA-directed DNA polymerase activity
MN0502_13640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MN0502_13650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MN0502_13690	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MN0502_13700	COG0174	glutamine synthetase
MN0502_13710	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MN0502_13750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MN0502_13760	COG0321	lipoyl(octanoyl) transferase activity
MN0502_13800	COG0793	Belongs to the peptidase S41A family
MN0502_13800	COG4946	Tricorn protease homolog
MN0502_13810	COG1764	response to oxidative stress
MN0502_13820	COG0508	dehydrogenase complex catalyzes the overall conversion of
MN0502_13830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MN0502_13840	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MN0502_13850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MN0502_13890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MN0502_13930	COG1271	oxidase subunit
MN0502_13940	COG1294	oxidase, subunit
MN0502_13950	COG4988	ABC transporter
MN0502_13980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MN0502_14050	COG1435	thymidine kinase activity
MN0502_14090	COG0756	dUTP diphosphatase activity
MN0502_14140	COG0569	domain protein
MN0502_14150	COG0531	amino acid
MN0502_14170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MN0502_14180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MN0502_14190	COG1530	ribonuclease E activity
MN0502_14200	COG0352	thiamine-phosphate diphosphorylase activity
MN0502_14200	COG0351	phosphomethylpyrimidine kinase
MN0502_14200	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MN0502_14210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MN0502_14220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MN0502_14230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MN0502_14240	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MN0502_14250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MN0502_14270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MN0502_14300	COG0406	alpha-ribazole phosphatase activity
MN0502_14340	COG3420	alginic acid biosynthetic process
MN0502_14450	COG4221	oxidoreductase activity
MN0502_14470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MN0502_14480	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MN0502_14490	COG1780	Probably involved in ribonucleotide reductase function
MN0502_14510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MN0502_14550	COG0667	Aldo Keto reductase
MN0502_14620	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_14630	COG2133	pyrroloquinoline quinone binding
MN0502_14640	COG2814	Major facilitator Superfamily
MN0502_14670	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_14730	COG0246	Mannitol dehydrogenase
MN0502_14750	COG1063	alcohol dehydrogenase
MN0502_14760	COG0395	ABC-type sugar transport system, permease component
MN0502_14850	COG0464	growth
MN0502_14900	COG3268	Saccharopine dehydrogenase
MN0502_14970	COG1234	tRNA 3'-trailer cleavage
MN0502_15040	COG2814	Major facilitator Superfamily
MN0502_15070	COG0667	Aldo Keto reductase
MN0502_15080	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MN0502_15090	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MN0502_15100	COG0352	thiamine-phosphate diphosphorylase activity
MN0502_15140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MN0502_15180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MN0502_15250	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MN0502_15270	COG0339	signal peptide processing
MN0502_15280	COG1929	Belongs to the glycerate kinase type-1 family
MN0502_15300	COG0745	RESPONSE REGULATOR receiver
MN0502_15310	COG5002	protein histidine kinase activity
MN0502_15330	COG2354	Protein conserved in bacteria
MN0502_15370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MN0502_15380	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MN0502_15390	COG0217	transcriptional regulatory protein
MN0502_15400	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MN0502_15410	COG0632	four-way junction helicase activity
MN0502_15420	COG2255	four-way junction helicase activity
MN0502_15440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MN0502_15450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MN0502_15460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MN0502_15480	COG1196	nuclear chromosome segregation
MN0502_15490	COG0124	histidyl-tRNA synthetase
MN0502_15510	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MN0502_15550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MN0502_15550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MN0502_15560	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MN0502_15570	COG0140	phosphoribosyl-ATP diphosphatase activity
MN0502_15580	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MN0502_15590	COG0107	imidazoleglycerol-phosphate synthase activity
MN0502_15610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MN0502_15660	COG0134	indole-3-glycerol-phosphate synthase activity
MN0502_15670	COG0133	tryptophan synthase activity
MN0502_15680	COG0159	tryptophan synthase activity
MN0502_15690	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MN0502_15700	COG0067	glutamate synthase
MN0502_15700	COG0069	glutamate synthase activity
MN0502_15700	COG0070	glutamate synthase
MN0502_15790	COG0745	RESPONSE REGULATOR receiver
MN0502_15820	COG2050	protein possibly involved in aromatic compounds catabolism
MN0502_15870	COG2813	Specifically methylates the guanine in position
MN0502_15920	COG0514	ATP-dependent DNA helicase (RecQ)
MN0502_15950	COG0556	nucleotide-excision repair
MN0502_15960	COG0861	Integral membrane protein TerC family
MN0502_16000	COG4106	trans-aconitate 2-methyltransferase activity
MN0502_16060	COG0322	excinuclease ABC activity
MN0502_16070	COG1660	Displays ATPase and GTPase activities
MN0502_16090	COG1481	regulation of sporulation
MN0502_16120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MN0502_16130	COG0126	phosphoglycerate kinase activity
MN0502_16150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MN0502_16160	COG0363	glucosamine-6-phosphate deaminase activity
MN0502_16220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MN0502_16260	COG0109	protoheme IX farnesyltransferase activity
MN0502_16270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MN0502_16280	COG1612	heme a metabolic process
MN0502_16300	COG1131	(ABC) transporter
MN0502_16350	COG0396	ATPase activity
MN0502_16360	COG2151	metal-sulfur cluster biosynthetic enzyme
MN0502_16380	COG1122	ATPase activity
MN0502_16390	COG1268	BioY protein
MN0502_16400	COG0488	(ABC) transporter
MN0502_16440	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_16450	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_16460	COG0560	Phosphoserine phosphatase
MN0502_16460	COG3830	Belongs to the UPF0237 family
MN0502_16470	COG1119	ATPase activity
MN0502_16490	COG0254	rRNA binding
MN0502_16500	COG0095	Lipoate-protein ligase
MN0502_16540	COG1305	Transglutaminase-like
MN0502_16550	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MN0502_16560	COG0297	glycogen (starch) synthase activity
MN0502_16680	COG1533	DNA photolyase activity
MN0502_16700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MN0502_16740	COG0667	Aldo Keto reductase
MN0502_16750	COG1968	undecaprenyl-diphosphatase activity
MN0502_16760	COG0215	cysteine-tRNA ligase activity
MN0502_16780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MN0502_16810	COG1222	aaa ATPase
MN0502_16820	COG4122	O-methyltransferase activity
MN0502_16840	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MN0502_16850	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MN0502_16860	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MN0502_16870	COG0545	Peptidyl-prolyl cis-trans isomerase
MN0502_16890	COG2378	regulation of single-species biofilm formation
MN0502_16910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MN0502_16920	COG0805	protein transport
MN0502_16930	COG4581	dead DEAH box helicase
MN0502_16940	COG1228	amidohydrolase
MN0502_16950	COG1216	Glycosyl transferase, family 2
MN0502_17000	COG0823	Involved in the tonB-independent uptake of proteins
MN0502_17000	COG1506	peptidase
MN0502_17000	COG4946	Tricorn protease homolog
MN0502_17010	COG0242	peptide deformylase activity
MN0502_17020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MN0502_17030	COG2197	response regulator
MN0502_17080	COG0681	Belongs to the peptidase S26 family
MN0502_17090	COG0110	maltose O-acetyltransferase activity
MN0502_17150	COG1064	alcohol dehydrogenase
MN0502_17160	COG0110	maltose O-acetyltransferase activity
MN0502_17250	COG4221	oxidoreductase activity
MN0502_17260	COG2197	response regulator
MN0502_17320	COG0747	negative chemotaxis
MN0502_17340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MN0502_17460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MN0502_17470	COG1845	cytochrome c oxidase, subunit III
MN0502_17480	COG2010	Cytochrome c
MN0502_17490	COG0723	plastoquinol--plastocyanin reductase activity
MN0502_17500	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MN0502_17520	COG2188	Transcriptional regulator
MN0502_17540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MN0502_17550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MN0502_17570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MN0502_17590	COG0167	dihydroorotate dehydrogenase activity
MN0502_17610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MN0502_17620	COG1381	Involved in DNA repair and RecF pathway recombination
MN0502_17630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MN0502_17640	COG3590	peptidase
MN0502_17650	COG1316	TRANSCRIPTIONal
MN0502_17660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MN0502_17680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MN0502_17720	COG0484	heat shock protein binding
MN0502_17730	COG1420	regulation of RNA biosynthetic process
MN0502_17780	COG0481	GTPase activity
MN0502_17800	COG0268	Binds directly to 16S ribosomal RNA
MN0502_17840	COG1596	polysaccharide export
MN0502_17840	COG1555	photosystem II stabilization
MN0502_17860	COG1307	EDD domain protein, DegV family
MN0502_17870	COG0495	leucyl-tRNA aminoacylation
MN0502_17880	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MN0502_17890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MN0502_17900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MN0502_17920	COG0604	alcohol dehydrogenase
MN0502_17940	COG0656	L-ascorbic acid biosynthetic process
MN0502_18000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MN0502_18020	COG1758	RNA polymerase activity
MN0502_18030	COG0194	GDP metabolic process
MN0502_18040	COG0194	GDP metabolic process
MN0502_18050	COG0284	orotidine-5'-phosphate decarboxylase activity
MN0502_18060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MN0502_18070	COG0505	Belongs to the CarA family
MN0502_18090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MN0502_18100	COG0540	Belongs to the ATCase OTCase family
MN0502_18110	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MN0502_18130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MN0502_18140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MN0502_18150	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MN0502_18160	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MN0502_18170	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MN0502_18190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MN0502_18210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MN0502_18220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MN0502_18250	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MN0502_18280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MN0502_18310	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MN0502_18410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MN0502_18470	COG0183	Belongs to the thiolase family
MN0502_18480	COG1024	Enoyl-CoA hydratase
MN0502_18480	COG1250	3-hydroxyacyl-CoA dehydrogenase
MN0502_18490	COG0667	Aldo Keto reductase
MN0502_18500	COG0105	UTP biosynthetic process
MN0502_18520	COG0285	dihydrofolate synthase activity
MN0502_18530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MN0502_18570	COG0525	valine-tRNA ligase activity
MN0502_18580	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MN0502_18600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MN0502_18610	COG0740	serine-type endopeptidase activity
MN0502_18620	COG0740	serine-type endopeptidase activity
MN0502_18630	COG0544	peptidyl-prolyl cis-trans isomerase activity
MN0502_18650	COG0698	ribose 5-phosphate isomerase
MN0502_18730	COG1946	Acyl-CoA thioesterase
MN0502_18790	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MN0502_18820	COG0242	peptide deformylase activity
MN0502_18850	COG0406	alpha-ribazole phosphatase activity
MN0502_18850	COG0328	RNA-DNA hybrid ribonuclease activity
MN0502_18870	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MN0502_18880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MN0502_18900	COG1045	serine acetyltransferase
MN0502_18910	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MN0502_18920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MN0502_18980	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MN0502_19010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MN0502_19020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MN0502_19030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MN0502_19060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MN0502_19080	COG0606	chelatase, subunit chli
MN0502_19090	COG0792	nuclease activity
MN0502_19120	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MN0502_19140	COG0681	Belongs to the peptidase S26 family
MN0502_19150	COG0335	large ribosomal subunit rRNA binding
MN0502_19160	COG0336	Belongs to the RNA methyltransferase TrmD family
MN0502_19170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MN0502_19180	COG1837	Belongs to the UPF0109 family
MN0502_19190	COG0228	four-way junction DNA binding
MN0502_19200	COG2514	catechol 2,3-dioxygenase activity
MN0502_19250	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MN0502_19290	COG0477	Major facilitator Superfamily
MN0502_19300	COG1196	nuclear chromosome segregation
MN0502_19320	COG1196	nuclear chromosome segregation
MN0502_19330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MN0502_19340	COG0318	PFAM AMP-dependent synthetase and ligase
MN0502_19350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MN0502_19360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MN0502_19370	COG1388	LysM domain
MN0502_19370	COG0791	NLP P60 protein
MN0502_19370	COG3103	Sh3 type 3 domain protein
MN0502_19390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MN0502_19400	COG0571	ribonuclease III activity
MN0502_19410	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MN0502_19440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MN0502_19480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MN0502_19530	COG0742	ribosomal rna small subunit methyltransferase
MN0502_19570	COG3585	molybdate ion transport
MN0502_19590	COG1461	Dihydroxyacetone kinase
MN0502_19610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MN0502_19630	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MN0502_19640	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MN0502_19650	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MN0502_19690	COG0438	transferase activity, transferring glycosyl groups
MN0502_19710	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MN0502_19730	COG1134	teichoic acid transport
MN0502_19750	COG0297	glycogen (starch) synthase activity
MN0502_19780	COG1316	TRANSCRIPTIONal
MN0502_19800	COG1088	dTDP-glucose 4,6-dehydratase activity
MN0502_19830	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_19860	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MN0502_19860	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MN0502_19890	COG2855	membrane
MN0502_19900	COG1181	Belongs to the D-alanine--D-alanine ligase family
MN0502_19910	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MN0502_19930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MN0502_19940	COG0066	3-isopropylmalate dehydratase activity
MN0502_19950	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MN0502_20000	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MN0502_20010	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MN0502_20040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MN0502_20050	COG0179	Fumarylacetoacetate (FAA) hydrolase
MN0502_20090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MN0502_20100	COG0473	3-isopropylmalate dehydrogenase activity
MN0502_20110	COG4585	Histidine kinase
MN0502_20120	COG2197	response regulator
MN0502_20130	COG0577	efflux transmembrane transporter activity
MN0502_20130	COG1136	(ABC) transporter
MN0502_20140	COG1136	(ABC) transporter
MN0502_20140	COG0577	efflux transmembrane transporter activity
MN0502_20150	COG5002	protein histidine kinase activity
MN0502_20190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MN0502_20200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MN0502_20210	COG0440	acetolactate synthase activity
MN0502_20230	COG0129	dihydroxy-acid dehydratase activity
MN0502_20250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MN0502_20350	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MN0502_20350	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MN0502_20390	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MN0502_20390	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MN0502_20400	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MN0502_20410	COG0438	transferase activity, transferring glycosyl groups
MN0502_20460	COG1191	sigma factor activity
MN0502_20500	COG0747	negative chemotaxis
MN0502_20510	COG0579	oxidoreductase
MN0502_20530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MN0502_20550	COG1305	Transglutaminase-like
MN0502_20600	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MN0502_20610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MN0502_20650	COG2815	serine threonine protein kinase
MN0502_20650	COG0515	serine threonine protein kinase
MN0502_20680	COG0419	ATPase involved in DNA repair
MN0502_20690	COG0420	3'-5' exonuclease activity
MN0502_20700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MN0502_20760	COG0586	Pfam SNARE associated Golgi protein
MN0502_20770	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MN0502_20780	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MN0502_20790	COG1234	tRNA 3'-trailer cleavage
MN0502_20800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MN0502_20820	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MN0502_20850	COG1335	isochorismatase
MN0502_20950	COG1902	pentaerythritol trinitrate reductase activity
MN0502_20960	COG1902	pentaerythritol trinitrate reductase activity
MN0502_21040	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MN0502_21070	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MN0502_21080	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MN0502_21090	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MN0502_21100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MN0502_21110	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MN0502_21120	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MN0502_21130	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MN0502_21140	COG0356	it plays a direct role in the translocation of protons across the membrane
MN0502_21180	COG1086	Polysaccharide biosynthesis protein
MN0502_21190	COG1216	Glycosyl transferase, family 2
MN0502_21220	COG1216	Glycosyl transferase, family 2
MN0502_21230	COG2890	protein-(glutamine-N5) methyltransferase activity
MN0502_21240	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MN0502_21270	COG0083	homoserine kinase activity
MN0502_21280	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MN0502_21290	COG0460	homoserine dehydrogenase
MN0502_21300	COG0019	diaminopimelate decarboxylase activity
MN0502_21310	COG0018	arginyl-trna synthetase
MN0502_21340	COG0543	2 iron, 2 sulfur cluster binding
MN0502_21340	COG0633	Ferredoxin
MN0502_21370	COG0714	Associated with various cellular activities
MN0502_21420	COG1643	Atp-dependent helicase
MN0502_21510	COG1121	(ABC) transporter
MN0502_21570	COG0508	dehydrogenase complex catalyzes the overall conversion of
MN0502_21570	COG0567	Dehydrogenase, E1 component
MN0502_21610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MN0502_21620	COG4172	Belongs to the ABC transporter superfamily
MN0502_21630	COG0604	alcohol dehydrogenase
MN0502_21650	COG1595	DNA-templated transcription, initiation
MN0502_21670	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MN0502_21690	COG1278	Cold shock
MN0502_21700	COG0483	inositol monophosphate 1-phosphatase activity
MN0502_21710	COG2226	methyltransferase
MN0502_21730	COG1121	(ABC) transporter
MN0502_21740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MN0502_21750	COG1321	iron dependent repressor
MN0502_21760	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MN0502_21790	COG1876	peptidase activity
MN0502_21810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MN0502_21830	COG2177	Part of the ABC transporter FtsEX involved in
MN0502_21840	COG2884	Cell division ATP-binding protein ftsE
MN0502_21850	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MN0502_21860	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MN0502_21960	COG5479	isomerase activity
MN0502_21960	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MN0502_21970	COG5479	isomerase activity
MN0502_21970	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MN0502_22020	COG0463	Glycosyl transferase, family 2
MN0502_22080	COG1216	Glycosyl transferase, family 2
MN0502_22110	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MN0502_22110	COG2755	lipolytic protein G-D-S-L family
MN0502_22180	COG2902	Dehydrogenase
MN0502_22260	COG0653	protein targeting
MN0502_22270	COG3214	Protein conserved in bacteria
MN0502_22280	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MN0502_22300	COG5401	PFAM Sporulation and spore germination
MN0502_22310	COG5000	phosphorelay sensor kinase activity
MN0502_22310	COG5002	protein histidine kinase activity
MN0502_22320	COG0745	RESPONSE REGULATOR receiver
MN0502_22360	COG0714	Associated with various cellular activities
MN0502_22410	COG0482	sulfurtransferase activity
MN0502_22420	COG0482	sulfurtransferase activity
MN0502_22450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MN0502_22470	COG0484	heat shock protein binding
MN0502_22490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MN0502_22510	COG1595	DNA-templated transcription, initiation
MN0502_22540	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MN0502_22550	COG2086	electron transfer activity
MN0502_22600	COG1842	Phage shock protein A
MN0502_22610	COG0415	Belongs to the DNA photolyase family
MN0502_22620	COG1615	UPF0182 protein
MN0502_22630	COG1615	UPF0182 protein
MN0502_22640	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MN0502_22700	COG0210	DNA helicase
MN0502_22740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MN0502_22750	COG0113	porphobilinogen synthase activity
MN0502_22770	COG0181	hydroxymethylbilane synthase activity
MN0502_22810	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MN0502_22820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MN0502_22890	COG0513	Belongs to the DEAD box helicase family
MN0502_22910	COG2189	Belongs to the N(4) N(6)-methyltransferase family
MN0502_22920	COG0613	PHP domain protein
MN0502_22930	COG0006	proline dipeptidase activity
MN0502_22950	COG2239	Acts as a magnesium transporter
MN0502_22970	COG0489	protein tyrosine kinase activity
MN0502_22970	COG2151	metal-sulfur cluster biosynthetic enzyme
MN0502_22990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MN0502_23040	COG0519	Catalyzes the synthesis of GMP from XMP
MN0502_23070	COG1126	abc transporter atp-binding protein
MN0502_23080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MN0502_23090	COG0765	amino acid transport
MN0502_23100	COG0765	amino acid transport
MN0502_23150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MN0502_23280	COG0601	transmembrane transport
MN0502_23290	COG4166	transmembrane transport
MN0502_23320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MN0502_23440	COG0656	L-ascorbic acid biosynthetic process
MN0502_23470	COG0012	GTP binding
MN0502_23490	COG1322	Protein conserved in bacteria
MN0502_23520	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MN0502_23540	COG1570	exodeoxyribonuclease VII activity
MN0502_23550	COG1722	exodeoxyribonuclease VII activity
MN0502_23560	COG2326	polyphosphate kinase activity
MN0502_23570	COG0436	Aminotransferase
MN0502_23600	COG1174	glycine betaine transport
MN0502_23620	COG2971	BadF BadG BcrA BcrD
MN0502_23730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MN0502_23780	COG0519	Catalyzes the synthesis of GMP from XMP
MN0502_23780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MN0502_23810	COG1132	(ABC) transporter
MN0502_23820	COG1132	(ABC) transporter
MN0502_23830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MN0502_23830	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MN0502_23840	COG0516	GMP reductase activity
MN0502_23860	COG4412	M6 family metalloprotease domain protein
MN0502_23860	COG3291	Pkd domain containing protein
MN0502_23920	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MN0502_23920	COG2755	lipolytic protein G-D-S-L family
MN0502_23930	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MN0502_23940	COG0459	protein refolding
MN0502_23950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MN0502_23980	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MN0502_23990	COG4605	iron ion homeostasis
MN0502_24000	COG4604	ABC transporter, ATP-binding protein
MN0502_24070	COG0384	phenazine biosynthesis protein PhzF
MN0502_24110	COG5640	endopeptidase activity
MN0502_24150	COG1175	transmembrane transport
MN0502_24160	COG0395	ABC-type sugar transport system, permease component
MN0502_24190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MN0502_24200	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MN0502_24210	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_24240	COG3401	FG-GAP repeat protein
MN0502_24300	COG0395	ABC-type sugar transport system, permease component
MN0502_24310	COG1175	transmembrane transport
MN0502_24330	COG3458	cephalosporin-C deacetylase activity
MN0502_24340	COG3401	FG-GAP repeat protein
MN0502_24350	COG0246	Mannitol dehydrogenase
MN0502_24360	COG2213	PTS system mannitol-specific
MN0502_24360	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MN0502_24380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MN0502_24390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MN0502_24480	COG0673	inositol 2-dehydrogenase activity
MN0502_24530	COG3321	synthase
MN0502_24530	COG0604	alcohol dehydrogenase
MN0502_24570	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MN0502_24580	COG0456	acetyltransferase
MN0502_24610	COG0802	atpase or kinase
MN0502_24620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MN0502_24630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MN0502_24640	COG1309	transcriptional regulator
MN0502_24660	COG3422	double-strand break repair
MN0502_24680	COG1486	melibiose metabolic process
MN0502_24700	COG0667	Aldo Keto reductase
MN0502_24710	COG0745	RESPONSE REGULATOR receiver
MN0502_24710	COG3706	GGDEF domain
MN0502_24770	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MN0502_24770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MN0502_24780	COG0736	holo-[acyl-carrier-protein] synthase activity
MN0502_24790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MN0502_24800	COG1072	(Pantothenic acid kinase))
MN0502_24850	COG2223	nitrite transmembrane transporter activity
MN0502_24860	COG0243	molybdopterin cofactor binding
MN0502_24890	COG1648	precorrin-2 dehydrogenase activity
MN0502_24890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MN0502_24900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MN0502_24910	COG2146	nitrite reductase [NAD(P)H] activity
MN0502_24930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MN0502_24940	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MN0502_24950	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MN0502_25000	COG1192	Involved in chromosome partitioning
MN0502_25070	COG5002	protein histidine kinase activity
MN0502_25090	COG0101	tRNA pseudouridine synthase activity
MN0502_25100	COG0203	ribosomal protein L17
MN0502_25110	COG0202	RNA polymerase activity
MN0502_25120	COG0202	RNA polymerase activity
MN0502_25130	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MN0502_25140	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MN0502_25150	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MN0502_25170	COG0563	adenylate kinase activity
MN0502_25190	COG0200	Binds to the 23S rRNA
MN0502_25200	COG1841	ribosomal large subunit assembly
MN0502_25210	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MN0502_25220	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MN0502_25230	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MN0502_25240	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MN0502_25250	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MN0502_25260	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MN0502_25270	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MN0502_25280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MN0502_25290	COG0255	Belongs to the universal ribosomal protein uL29 family
MN0502_25300	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MN0502_25310	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MN0502_25320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MN0502_25330	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MN0502_25340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MN0502_25350	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MN0502_25360	COG0089	rRNA binding
MN0502_25370	COG0088	Forms part of the polypeptide exit tunnel
MN0502_25380	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MN0502_25390	COG0051	transcription antitermination factor activity, RNA binding
MN0502_25400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MN0502_25410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MN0502_25420	COG0049	tRNA binding
MN0502_25430	COG0049	tRNA binding
MN0502_25440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MN0502_25450	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MN0502_25460	COG0085	RNA polymerase activity
MN0502_25500	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MN0502_25510	COG0183	Belongs to the thiolase family
MN0502_25520	COG0222	ribosome binding
MN0502_25530	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MN0502_25550	COG0081	regulation of translation
MN0502_25560	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MN0502_25580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MN0502_25590	COG0436	Aminotransferase
MN0502_25600	COG2197	response regulator
MN0502_25660	COG1233	COG1233 Phytoene dehydrogenase and related
MN0502_25710	COG0354	folic acid binding
MN0502_25720	COG3485	protocatechuate 3,4-dioxygenase
MN0502_25740	COG0745	RESPONSE REGULATOR receiver
MN0502_25750	COG0456	acetyltransferase
MN0502_25760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MN0502_25830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MN0502_25840	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MN0502_25850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MN0502_25880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MN0502_25900	COG2030	dehydratase
MN0502_25930	COG1793	dna ligase
MN0502_25940	COG0693	protein deglycase activity
MN0502_25950	COG1396	sequence-specific DNA binding
MN0502_25980	COG1690	Belongs to the RtcB family
MN0502_26010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MN0502_26020	COG1120	ATPase activity
MN0502_26030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MN0502_26110	COG1794	racemase activity, acting on amino acids and derivatives
MN0502_26170	COG1051	belongs to the nudix hydrolase family
MN0502_26270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MN0502_26290	COG2814	Major facilitator Superfamily
MN0502_26340	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MN0502_26340	COG2755	lipolytic protein G-D-S-L family
MN0502_26370	COG1666	GTP binding
MN0502_26380	COG0501	Belongs to the peptidase M48B family
MN0502_26440	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MN0502_26470	COG2409	Drug exporters of the RND superfamily
MN0502_26490	COG0667	Aldo Keto reductase
MN0502_26530	COG0739	heme binding
MN0502_26530	COG0741	lytic transglycosylase activity
MN0502_26530	COG1196	nuclear chromosome segregation
MN0502_26660	COG1012	belongs to the aldehyde dehydrogenase family
MN0502_26680	COG2508	Transcriptional regulator
MN0502_26680	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MN0502_26700	COG5002	protein histidine kinase activity
MN0502_26730	COG1366	Belongs to the anti-sigma-factor antagonist family
MN0502_26760	COG2860	membrane
MN0502_26790	COG0537	adenosine 5'-monophosphoramidase activity
MN0502_26830	COG2226	methyltransferase
MN0502_26840	COG1169	isochorismate synthase
MN0502_26870	COG0765	amino acid transport
MN0502_26890	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MN0502_26910	COG4948	Mandelate Racemase Muconate Lactonizing
MN0502_26930	COG1063	alcohol dehydrogenase
MN0502_26990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MN0502_27020	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MN0502_27030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MN0502_27100	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MN0502_27110	COG2017	converts alpha-aldose to the beta-anomer
MN0502_27120	COG3534	alpha-L-arabinofuranosidase
MN0502_27130	COG0395	ABC-type sugar transport system, permease component
MN0502_27170	COG0277	FAD linked oxidase domain protein
MN0502_27190	COG2364	Membrane
MN0502_27210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MN0502_27220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MN0502_27250	COG0508	dehydrogenase complex catalyzes the overall conversion of
MN0502_27260	COG0022	dehydrogenase e1 component
MN0502_27330	COG1024	Enoyl-CoA hydratase
MN0502_27340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MN0502_27350	COG2151	metal-sulfur cluster biosynthetic enzyme
MN0502_27360	COG3396	Phenylacetate-CoA oxygenase
MN0502_27370	COG3460	Phenylacetate-CoA oxygenase
MN0502_27380	COG3396	Phenylacetate-CoA oxygenase
MN0502_27440	COG2030	dehydratase
MN0502_27440	COG1012	belongs to the aldehyde dehydrogenase family
MN0502_27480	COG1250	3-hydroxyacyl-CoA dehydrogenase
MN0502_27500	COG1024	Enoyl-CoA hydratase
MN0502_27550	COG0395	ABC-type sugar transport system, permease component
MN0502_27560	COG1175	transmembrane transport
MN0502_27590	COG2050	protein possibly involved in aromatic compounds catabolism
MN0502_27600	COG2755	lipolytic protein G-D-S-L family
MN0502_27610	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MN0502_27660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MN0502_27680	COG0785	Cytochrome C biogenesis protein
MN0502_27700	COG0406	alpha-ribazole phosphatase activity
MN0502_27710	COG2353	YceI-like domain
MN0502_27730	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MN0502_27750	COG0560	Phosphoserine phosphatase
MN0502_27770	COG0640	Transcriptional regulator
MN0502_27780	COG0123	including yeast histone deacetylase and acetoin utilization protein
MN0502_27790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MN0502_27810	COG1051	belongs to the nudix hydrolase family
MN0502_27830	COG1082	Xylose isomerase domain protein TIM barrel
MN0502_27840	COG0248	Ppx GppA phosphatase
MN0502_27850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MN0502_27850	COG1754	DNA topoisomerase type I activity
MN0502_27860	COG2890	protein-(glutamine-N5) methyltransferase activity
MN0502_27890	COG1205	dead DEAH box helicase
MN0502_27890	COG1111	helicase
MN0502_27990	COG0494	nUDIX hydrolase
MN0502_28020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MN0502_28030	COG1764	response to oxidative stress
MN0502_28050	COG0477	Major facilitator Superfamily
MN0502_28120	COG0747	negative chemotaxis
MN0502_28200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MN0502_28210	COG1408	metallophosphoesterase
MN0502_28230	COG1132	(ABC) transporter
MN0502_28250	COG0697	spore germination
MN0502_28260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MN0502_28270	COG0151	Belongs to the GarS family
MN0502_28370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MN0502_28380	COG3693	PFAM glycoside hydrolase, family 10
MN0502_28410	COG1609	Transcriptional regulator
MN0502_28420	COG2115	Belongs to the xylose isomerase family
MN0502_28430	COG1070	Carbohydrate kinase
MN0502_28440	COG1070	Carbohydrate kinase
MN0502_28450	COG1070	Carbohydrate kinase
MN0502_28500	COG1175	transmembrane transport
MN0502_28510	COG1653	transport
MN0502_28540	COG1940	carbohydrate kinase activity
MN0502_28540	COG1846	Transcriptional regulator
MN0502_28570	COG0542	response to heat
MN0502_28600	COG2268	Band 7 protein
MN0502_28610	COG3304	Inner membrane component domain
MN0502_28630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MN0502_28640	COG2814	Major facilitator Superfamily
MN0502_28660	COG1309	transcriptional regulator
MN0502_28680	COG4221	oxidoreductase activity
MN0502_28720	COG0366	Alpha amylase catalytic
MN0502_28740	COG0789	Transcriptional regulator
MN0502_28750	COG0484	heat shock protein binding
MN0502_28760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MN0502_28770	COG0443	Heat shock 70 kDa protein
MN0502_28850	COG3706	GGDEF domain
MN0502_28890	COG0583	DNA-binding transcription factor activity
MN0502_28910	COG0745	RESPONSE REGULATOR receiver
MN0502_28930	COG3422	double-strand break repair
MN0502_28950	COG2205	protein histidine kinase activity
MN0502_28960	COG0745	RESPONSE REGULATOR receiver
MN0502_28980	COG2409	Drug exporters of the RND superfamily
MN0502_28990	COG1846	Transcriptional regulator
MN0502_29010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MN0502_29020	COG1280	lysine exporter protein (LysE YggA)
MN0502_29060	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MN0502_29100	COG0765	amino acid transport
MN0502_29110	COG1126	abc transporter atp-binding protein
MN0502_29130	COG1122	ATPase activity
MN0502_29170	COG1113	amino acid transport
MN0502_29200	COG2154	pterin-4-alpha-carbinolamine dehydratase
MN0502_29230	COG0745	RESPONSE REGULATOR receiver
MN0502_29250	COG2212	antiporter activity
MN0502_29290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MN0502_29290	COG2111	Na H antiporter
MN0502_29310	COG0717	Belongs to the dCTP deaminase family
MN0502_29320	COG3483	tryptophan 2,3-dioxygenase activity
MN0502_29350	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MN0502_29420	COG0433	COG0433 Predicted ATPase
MN0502_29480	COG3336	cytochrome c oxidase
MN0502_29490	COG0776	regulation of translation
MN0502_29500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MN0502_29510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MN0502_29520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MN0502_29570	COG1597	lipid kinase activity
MN0502_29580	COG0739	heme binding
MN0502_29600	COG1120	ATPase activity
MN0502_29610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MN0502_29630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MN0502_29650	COG0435	Glutathione S-transferase
MN0502_29660	COG1295	ribonuclease BN
MN0502_29690	COG5002	protein histidine kinase activity
MN0502_29690	COG0784	Response regulator, receiver
MN0502_29690	COG2198	Histidine kinase
MN0502_29700	COG1064	alcohol dehydrogenase
MN0502_29710	COG1064	alcohol dehydrogenase
MN0502_29730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MN0502_29770	COG0385	Bile acid
MN0502_29860	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MN0502_29870	COG1473	amidohydrolase
MN0502_29890	COG0488	(ABC) transporter
MN0502_29900	COG0488	(ABC) transporter
MN0502_29910	COG2076	Multidrug Resistance protein
MN0502_29930	COG0861	Integral membrane protein TerC family
MN0502_29940	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MN0502_29950	COG0667	Aldo Keto reductase
MN0502_29960	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MN0502_29990	COG4221	oxidoreductase activity
MN0502_30030	COG1846	Transcriptional regulator
MN0502_30080	COG0673	inositol 2-dehydrogenase activity
MN0502_30110	COG1609	Transcriptional regulator
MN0502_30160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MN0502_30190	COG2814	Major facilitator Superfamily
MN0502_30250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MN0502_30330	COG0395	ABC-type sugar transport system, permease component
MN0502_30350	COG0457	Tetratricopeptide repeat
MN0502_30400	COG1316	TRANSCRIPTIONal
MN0502_30450	COG1115	amino acid carrier protein
MN0502_30460	COG1131	(ABC) transporter
MN0502_30470	COG1131	(ABC) transporter
MN0502_30510	COG2130	NADP-dependent
MN0502_30530	COG0656	L-ascorbic acid biosynthetic process
MN0502_30580	COG0671	phosphoesterase, PA-phosphatase related
MN0502_30600	COG0531	amino acid
MN0502_30610	COG0531	amino acid
MN0502_30710	COG2186	Transcriptional regulator
MN0502_30830	COG3387	PFAM Glycoside hydrolase 15-related
MN0502_30860	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_30870	COG0406	alpha-ribazole phosphatase activity
MN0502_30880	COG2807	transmembrane transport
MN0502_31090	COG1802	Transcriptional regulator
MN0502_31120	COG3971	2-oxopent-4-enoate hydratase activity
MN0502_31210	COG2199	diguanylate cyclase activity
MN0502_31210	COG2200	EAL domain
MN0502_31210	COG2203	Gaf domain
MN0502_31250	COG1846	Transcriptional regulator
MN0502_31270	COG1063	alcohol dehydrogenase
MN0502_31280	COG2315	Protein conserved in bacteria
MN0502_31290	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MN0502_31350	COG1172	Belongs to the binding-protein-dependent transport system permease family
MN0502_31360	COG1172	Belongs to the binding-protein-dependent transport system permease family
MN0502_31370	COG1172	Belongs to the binding-protein-dependent transport system permease family
MN0502_31380	COG1129	ABC transporter
MN0502_31410	COG3347	Dehydrogenase
MN0502_31410	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_31440	COG3706	GGDEF domain
MN0502_31450	COG0789	Transcriptional regulator
MN0502_31490	COG0686	Belongs to the AlaDH PNT family
MN0502_31500	COG0673	inositol 2-dehydrogenase activity
MN0502_31510	COG1309	transcriptional regulator
MN0502_31570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MN0502_31590	COG0508	dehydrogenase complex catalyzes the overall conversion of
MN0502_31600	COG0022	dehydrogenase e1 component
MN0502_31620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MN0502_31650	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MN0502_31710	COG0667	Aldo Keto reductase
MN0502_31720	COG3046	protein related to deoxyribodipyrimidine photolyase
MN0502_31760	COG1172	Belongs to the binding-protein-dependent transport system permease family
MN0502_31780	COG1082	Xylose isomerase domain protein TIM barrel
MN0502_31790	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MN0502_31810	COG0154	amidase activity
MN0502_31820	COG2957	Belongs to the agmatine deiminase family
MN0502_31880	COG3250	beta-galactosidase activity
MN0502_31890	COG3265	gluconokinase activity
MN0502_31900	COG4948	Mandelate Racemase Muconate Lactonizing
MN0502_31930	COG1904	glucuronate isomerase
MN0502_31950	COG0444	Belongs to the ABC transporter superfamily
MN0502_31970	COG0747	negative chemotaxis
MN0502_31980	COG1609	Transcriptional regulator
MN0502_32000	COG1172	Belongs to the binding-protein-dependent transport system permease family
MN0502_32010	COG1129	ABC transporter
MN0502_32020	COG1879	ABC-type sugar transport system periplasmic component
MN0502_32030	COG0457	Tetratricopeptide repeat
MN0502_32040	COG4977	sequence-specific DNA binding
MN0502_32050	COG2017	converts alpha-aldose to the beta-anomer
MN0502_32150	COG1970	mechanosensitive ion channel activity
MN0502_32170	COG0477	Major facilitator Superfamily
MN0502_32190	COG2205	protein histidine kinase activity
MN0502_32200	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MN0502_32260	COG1937	Protein conserved in bacteria
MN0502_32290	COG0673	inositol 2-dehydrogenase activity
MN0502_32340	COG1175	transmembrane transport
MN0502_32370	COG2376	Dihydroxyacetone kinase
MN0502_32380	COG0698	ribose 5-phosphate isomerase
MN0502_32390	COG0149	triose-phosphate isomerase activity
MN0502_32430	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_32440	COG2271	Major facilitator Superfamily
MN0502_32460	COG2084	Dehydrogenase
MN0502_32500	COG0659	secondary active sulfate transmembrane transporter activity
MN0502_32580	COG0071	Belongs to the small heat shock protein (HSP20) family
MN0502_32610	COG4213	ABC transporter substrate-binding protein
MN0502_32620	COG1129	ABC transporter
MN0502_32630	COG4214	carbohydrate transport
MN0502_32730	COG1070	Carbohydrate kinase
MN0502_32740	COG1063	alcohol dehydrogenase
MN0502_32750	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_32760	COG2610	gluconate transmembrane transporter activity
MN0502_32770	COG2186	Transcriptional regulator
MN0502_32800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MN0502_32950	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MN0502_32980	COG1984	allophanate hydrolase subunit 2
MN0502_32990	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MN0502_33030	COG3546	catalase activity
MN0502_33110	COG0305	Participates in initiation and elongation during chromosome replication
MN0502_33120	COG0359	binds to the 23S rRNA
MN0502_33130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MN0502_33150	COG0360	Binds together with S18 to 16S ribosomal RNA
MN0502_33160	COG1362	aminopeptidase activity
MN0502_33170	COG2197	response regulator
MN0502_33180	COG4585	Histidine kinase
MN0502_33230	COG0738	Major facilitator superfamily
MN0502_33250	COG0488	(ABC) transporter
MN0502_33260	COG0488	(ABC) transporter
MN0502_33270	COG0745	RESPONSE REGULATOR receiver
MN0502_33280	COG2267	carboxylic ester hydrolase activity
MN0502_33290	COG1846	Transcriptional regulator
MN0502_33320	COG1760	l-serine dehydratase
MN0502_33330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MN0502_33340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MN0502_33340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MN0502_33350	COG2755	lipolytic protein G-D-S-L family
MN0502_33370	COG0243	molybdopterin cofactor binding
MN0502_33410	COG0745	RESPONSE REGULATOR receiver
MN0502_33490	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MN0502_33510	COG0438	transferase activity, transferring glycosyl groups
MN0502_33530	COG0406	alpha-ribazole phosphatase activity
MN0502_33540	COG0617	tRNA 3'-terminal CCA addition
MN0502_33590	COG3118	belongs to the thioredoxin family
MN0502_33610	COG1192	Involved in chromosome partitioning
MN0502_33620	COG0357	Ribosomal RNA small subunit methyltransferase G
MN0502_33640	COG0706	membrane insertase activity
MN0502_33650	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MN0502_33660	COG0594	ribonuclease P activity
MN0502_33730	COG3546	catalase activity
MN0502_33890	COG0596	Alpha beta hydrolase
MN0502_33920	COG2249	NAD(P)H dehydrogenase (quinone) activity
MN0502_33970	COG3591	Belongs to the peptidase S1B family
MN0502_33970	COG1864	DNA RNA non-specific endonuclease
MN0502_34090	COG2135	peptidase activity
MN0502_34250	COG0741	lytic transglycosylase activity
MN0502_34410	COG0363	glucosamine-6-phosphate deaminase activity
MN0502_34420	COG1940	carbohydrate kinase activity
MN0502_34440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MN0502_34450	COG0395	ABC-type sugar transport system, permease component
MN0502_34460	COG1175	transmembrane transport
MN0502_34490	COG1609	Transcriptional regulator
MN0502_34530	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MN0502_34630	COG1475	DNA binding
MN0502_34680	COG0697	spore germination
MN0502_34880	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_34890	COG0477	Major facilitator Superfamily
MN0502_34900	COG3959	Transketolase, thiamine diphosphate binding domain
MN0502_34910	COG3958	Transketolase
MN0502_34970	COG0511	ligase activity, forming carbon-carbon bonds
MN0502_34970	COG5016	pyruvate
MN0502_34980	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MN0502_34990	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MN0502_35000	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MN0502_35030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MN0502_35050	COG0640	Transcriptional regulator
MN0502_35080	COG1028	Short-chain dehydrogenase reductase Sdr
MN0502_35260	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MN0502_35270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs