locus-tag	class	description
HL663_00025	COG4106	trans-aconitate 2-methyltransferase activity
HL663_00035	COG0488	(ABC) transporter
HL663_00040	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HL663_00045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HL663_00050	COG3583	domain protein
HL663_00055	COG0084	hydrolase, TatD family'
HL663_00060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HL663_00070	COG1690	Belongs to the RtcB family
HL663_00120	COG1053	succinate dehydrogenase
HL663_00145	COG2318	DinB family
HL663_00170	COG0521	Mo-molybdopterin cofactor biosynthetic process
HL663_00175	COG0315	cyclic pyranopterin monophosphate synthase activity
HL663_00200	COG3263	regulation of cellular component size
HL663_00205	COG1131	(ABC) transporter
HL663_00225	COG1970	mechanosensitive ion channel activity
HL663_00235	COG2814	Major facilitator Superfamily
HL663_00245	COG5002	protein histidine kinase activity
HL663_00245	COG3447	MASE1 domain protein
HL663_00245	COG5001	Diguanylate cyclase
HL663_00250	COG5001	Diguanylate cyclase
HL663_00250	COG5002	protein histidine kinase activity
HL663_00255	COG5001	Diguanylate cyclase
HL663_00255	COG3300	MHYT domain
HL663_00260	COG0297	glycogen (starch) synthase activity
HL663_00305	COG0745	RESPONSE REGULATOR receiver
HL663_00310	COG2186	Transcriptional regulator
HL663_00315	COG1620	l-lactate permease
HL663_00320	COG0247	lactate metabolic process
HL663_00325	COG1139	Iron-sulfur cluster binding protein
HL663_00330	COG1556	Lactate utilization protein
HL663_00350	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_00375	COG1132	(ABC) transporter
HL663_00385	COG0791	NLP P60 protein
HL663_00385	COG1388	LysM domain
HL663_00385	COG3103	Sh3 type 3 domain protein
HL663_00420	COG0259	pyridoxamine-phosphate oxidase activity
HL663_00455	COG2252	PERMEase
HL663_00490	COG0745	RESPONSE REGULATOR receiver
HL663_00500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL663_00530	COG1136	(ABC) transporter
HL663_00530	COG0577	efflux transmembrane transporter activity
HL663_00545	COG0459	protein refolding
HL663_00575	COG1104	cysteine desulfurase activity
HL663_00580	COG0546	phosphoglycolate phosphatase activity
HL663_00585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HL663_00590	COG0798	PFAM Bile acid sodium symporter
HL663_00600	COG0640	Transcriptional regulator
HL663_00605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HL663_00615	COG1960	acyl-CoA dehydrogenase activity
HL663_00655	COG0745	RESPONSE REGULATOR receiver
HL663_00660	COG2205	protein histidine kinase activity
HL663_00665	COG2017	converts alpha-aldose to the beta-anomer
HL663_00675	COG1063	alcohol dehydrogenase
HL663_00690	COG0633	Ferredoxin
HL663_00690	COG0543	2 iron, 2 sulfur cluster binding
HL663_00695	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HL663_00705	COG1131	(ABC) transporter
HL663_00715	COG1131	(ABC) transporter
HL663_00770	COG1063	alcohol dehydrogenase
HL663_00775	COG4214	carbohydrate transport
HL663_00785	COG4213	ABC transporter substrate-binding protein
HL663_00790	COG1609	Transcriptional regulator
HL663_00805	COG2197	response regulator
HL663_00835	COG2267	carboxylic ester hydrolase activity
HL663_00840	COG0300	oxidoreductase activity
HL663_00860	COG1733	regulation of RNA biosynthetic process
HL663_00875	COG2205	protein histidine kinase activity
HL663_00890	COG4702	Belongs to the UPF0303 family
HL663_00910	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HL663_00915	COG1216	Glycosyl transferase, family 2
HL663_00930	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HL663_00935	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HL663_00950	COG1338	Plays a role in the flagellum-specific transport system
HL663_00965	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HL663_00975	COG1360	Flagellar Motor Protein
HL663_00980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HL663_01005	COG0741	lytic transglycosylase activity
HL663_01015	COG1157	protein secretion by the type III secretion system
HL663_01025	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HL663_01030	COG1766	The M ring may be actively involved in energy transduction
HL663_01035	COG1677	Flagellar hook-basal body complex protein FliE
HL663_01040	COG1558	bacterial-type flagellum-dependent cell motility
HL663_01065	COG1516	flagellar protein fliS
HL663_01075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HL663_01080	COG1191	sigma factor activity
HL663_01090	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HL663_01095	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HL663_01100	COG1316	TRANSCRIPTIONal
HL663_01120	COG3842	ATPase activity
HL663_01150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL663_01155	COG0215	cysteine-tRNA ligase activity
HL663_01160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL663_01225	COG0588	phosphoglycerate mutase activity
HL663_01235	COG0438	transferase activity, transferring glycosyl groups
HL663_01255	COG1490	D-aminoacyl-tRNA deacylase activity
HL663_01280	COG3246	L-lysine catabolic process to acetate
HL663_01295	COG1316	TRANSCRIPTIONal
HL663_01300	COG3485	protocatechuate 3,4-dioxygenase
HL663_01320	COG0745	RESPONSE REGULATOR receiver
HL663_01325	COG0456	acetyltransferase
HL663_01335	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HL663_01400	COG0515	serine threonine protein kinase
HL663_01440	COG1335	isochorismatase
HL663_01455	COG2814	Major facilitator Superfamily
HL663_01460	COG1846	Transcriptional regulator
HL663_01480	COG0582	viral genome integration into host DNA
HL663_01525	COG1051	belongs to the nudix hydrolase family
HL663_01590	COG0366	Alpha amylase catalytic
HL663_01595	COG0395	ABC-type sugar transport system, permease component
HL663_01610	COG1609	Transcriptional regulator
HL663_01635	COG2130	NADP-dependent
HL663_01645	COG2119	membrane
HL663_01650	COG1305	Transglutaminase-like
HL663_01670	COG0415	Belongs to the DNA photolyase family
HL663_01680	COG0702	epimerase
HL663_01690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HL663_01710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HL663_01725	COG2733	membrane
HL663_01740	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HL663_01740	COG1796	DNA polymerase
HL663_01795	COG0667	Aldo Keto reductase
HL663_01810	COG0598	Magnesium transport protein CorA
HL663_01820	COG1793	dna ligase
HL663_01830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HL663_01845	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HL663_01850	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HL663_01855	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HL663_01865	COG1024	Enoyl-CoA hydratase
HL663_01875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HL663_01880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_01910	COG2356	endonuclease I
HL663_01915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HL663_01920	COG1695	Transcriptional regulator
HL663_01930	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HL663_01935	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HL663_01945	COG0318	PFAM AMP-dependent synthetase and ligase
HL663_01960	COG2211	Major facilitator Superfamily
HL663_01975	COG2133	pyrroloquinoline quinone binding
HL663_01990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HL663_01995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HL663_02030	COG1609	Transcriptional regulator
HL663_02050	COG0463	Glycosyl transferase, family 2
HL663_02065	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HL663_02090	COG1063	alcohol dehydrogenase
HL663_02105	COG3284	Transcriptional regulator
HL663_02300	COG2910	NAD(P)H-binding
HL663_02325	COG1802	Transcriptional regulator
HL663_02335	COG3959	Transketolase, thiamine diphosphate binding domain
HL663_02340	COG3958	Transketolase
HL663_02345	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_02350	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HL663_02360	COG0745	RESPONSE REGULATOR receiver
HL663_02365	COG2205	protein histidine kinase activity
HL663_02375	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HL663_02400	COG0395	ABC-type sugar transport system, permease component
HL663_02410	COG1653	transport
HL663_02425	COG1316	TRANSCRIPTIONal
HL663_02430	COG0768	penicillin binding
HL663_02435	COG1278	Cold shock
HL663_02440	COG0589	response to stress
HL663_02460	COG1609	Transcriptional regulator
HL663_02510	COG1045	serine acetyltransferase
HL663_02520	COG2181	nitrate reductase activity
HL663_02520	COG0247	lactate metabolic process
HL663_02530	COG1174	glycine betaine transport
HL663_02535	COG1174	glycine betaine transport
HL663_02545	COG0477	Major facilitator Superfamily
HL663_02555	COG0717	Belongs to the dCTP deaminase family
HL663_02635	COG1960	acyl-CoA dehydrogenase activity
HL663_02650	COG0277	FAD linked oxidase domain protein
HL663_02660	COG3336	cytochrome c oxidase
HL663_02690	COG1960	acyl-CoA dehydrogenase activity
HL663_02715	COG0508	dehydrogenase complex catalyzes the overall conversion of
HL663_02720	COG0022	dehydrogenase e1 component
HL663_02765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HL663_02770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HL663_02780	COG1950	PFAM Membrane protein of
HL663_02785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HL663_02790	COG1271	oxidase subunit
HL663_02795	COG1294	oxidase, subunit
HL663_02800	COG4988	ABC transporter
HL663_02805	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HL663_02835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HL663_02850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HL663_02865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL663_02880	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HL663_02885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HL663_02905	COG1937	Protein conserved in bacteria
HL663_02945	COG0561	phosphatase activity
HL663_02955	COG1120	ATPase activity
HL663_02960	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL663_02965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL663_02980	COG4152	abc transporter atp-binding protein
HL663_02985	COG2197	response regulator
HL663_02990	COG4585	Histidine kinase
HL663_03000	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HL663_03010	COG1280	lysine exporter protein (LysE YggA)
HL663_03030	COG1597	lipid kinase activity
HL663_03035	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HL663_03040	COG0672	)-iron permease
HL663_03115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HL663_03120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_03130	COG2814	Major facilitator Superfamily
HL663_03145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_03150	COG1733	regulation of RNA biosynthetic process
HL663_03160	COG2354	Protein conserved in bacteria
HL663_03200	COG1012	belongs to the aldehyde dehydrogenase family
HL663_03235	COG1486	melibiose metabolic process
HL663_03240	COG1349	DNA-binding transcription factor activity
HL663_03245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL663_03255	COG1175	transmembrane transport
HL663_03260	COG0395	ABC-type sugar transport system, permease component
HL663_03270	COG0488	(ABC) transporter
HL663_03285	COG0450	alkyl hydroperoxide reductase
HL663_03315	COG2318	DinB family
HL663_03320	COG1403	HNH endonuclease
HL663_03350	COG0688	phosphatidylethanolamine metabolic process
HL663_03360	COG0840	transmembrane signaling receptor activity
HL663_03370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL663_03375	COG3540	Alkaline phosphatase
HL663_03380	COG2076	Multidrug Resistance protein
HL663_03390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HL663_03425	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HL663_03435	COG0395	ABC-type sugar transport system, permease component
HL663_03450	COG1349	DNA-binding transcription factor activity
HL663_03460	COG0513	Belongs to the DEAD box helicase family
HL663_03480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HL663_03515	COG0488	(ABC) transporter
HL663_03545	COG1823	symporter activity
HL663_03550	COG0024	Methionine aminopeptidase
HL663_03555	COG0515	serine threonine protein kinase
HL663_03560	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HL663_03570	COG2197	response regulator
HL663_03620	COG0395	ABC-type sugar transport system, permease component
HL663_03630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HL663_03635	COG2197	response regulator
HL663_03680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HL663_03685	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HL663_03690	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_03700	COG2193	ferroxidase activity
HL663_03725	COG3237	CsbD-like
HL663_03755	COG1302	Protein conserved in bacteria
HL663_03770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HL663_03785	COG1929	Belongs to the glycerate kinase type-1 family
HL663_03815	COG0659	secondary active sulfate transmembrane transporter activity
HL663_03865	COG1716	ATPase activity
HL663_03880	COG0768	penicillin binding
HL663_03885	COG0515	serine threonine protein kinase
HL663_03900	COG3764	Sortase (surface protein transpeptidase)
HL663_03910	COG0457	Tetratricopeptide repeat
HL663_03910	COG0705	Rhomboid family
HL663_03975	COG3266	domain, Protein
HL663_03980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HL663_03985	COG0187	DNA topoisomerase II activity
HL663_04000	COG1024	Enoyl-CoA hydratase
HL663_04015	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HL663_04030	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HL663_04035	COG0592	DNA-directed DNA polymerase activity
HL663_04040	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HL663_04045	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HL663_04050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HL663_04055	COG0706	membrane insertase activity
HL663_04065	COG0357	Ribosomal RNA small subunit methyltransferase G
HL663_04070	COG1192	Involved in chromosome partitioning
HL663_04080	COG3118	belongs to the thioredoxin family
HL663_04095	COG1595	DNA-templated transcription, initiation
HL663_04150	COG0714	Associated with various cellular activities
HL663_04170	COG1260	myo-inositol-1-phosphate synthase
HL663_04180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HL663_04190	COG0360	Binds together with S18 to 16S ribosomal RNA
HL663_04200	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HL663_04205	COG0359	binds to the 23S rRNA
HL663_04215	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HL663_04265	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HL663_04280	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HL663_04295	COG3285	dna ligase
HL663_04295	COG1793	dna ligase
HL663_04325	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HL663_04335	COG2188	Transcriptional regulator
HL663_04340	COG0673	inositol 2-dehydrogenase activity
HL663_04345	COG1082	Xylose isomerase domain protein TIM barrel
HL663_04350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL663_04360	COG3718	enzyme involved in inositol metabolism
HL663_04365	COG3962	Belongs to the TPP enzyme family
HL663_04370	COG0673	inositol 2-dehydrogenase activity
HL663_04380	COG1376	ErfK ybiS ycfS ynhG family protein
HL663_04390	COG2340	Cysteine-rich secretory protein family
HL663_04420	COG1744	ABC transporter substrate-binding protein PnrA-like
HL663_04425	COG0300	oxidoreductase activity
HL663_04435	COG0402	S-adenosylhomocysteine deaminase activity
HL663_04440	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HL663_04445	COG0405	Gamma-glutamyltransferase
HL663_04455	COG0534	Mate efflux family protein
HL663_04460	COG0427	acetyl-CoA hydrolase
HL663_04470	COG0305	Participates in initiation and elongation during chromosome replication
HL663_04485	COG0596	Alpha beta hydrolase
HL663_04520	COG0395	ABC-type sugar transport system, permease component
HL663_04535	COG1609	Transcriptional regulator
HL663_04560	COG1335	isochorismatase
HL663_04565	COG1051	belongs to the nudix hydrolase family
HL663_04575	COG2235	arginine
HL663_04585	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HL663_04615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HL663_04640	COG0604	alcohol dehydrogenase
HL663_04640	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_04640	COG3321	synthase
HL663_04650	COG1301	dicarboxylic acid transport
HL663_04655	COG3290	protein histidine kinase activity
HL663_04660	COG4565	transcriptional regulatory protein
HL663_04675	COG0477	Major facilitator Superfamily
HL663_04680	COG2814	Major facilitator Superfamily
HL663_04695	COG1984	allophanate hydrolase subunit 2
HL663_04700	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HL663_04705	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HL663_04735	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_04740	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HL663_04740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HL663_04745	COG2226	methyltransferase
HL663_04780	COG3046	protein related to deoxyribodipyrimidine photolyase
HL663_04785	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HL663_04800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HL663_04810	COG0114	fumarate hydratase activity
HL663_04815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HL663_04820	COG2205	protein histidine kinase activity
HL663_04825	COG0745	RESPONSE REGULATOR receiver
HL663_04860	COG1881	PFAM PEBP family protein
HL663_04865	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HL663_04870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HL663_04875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HL663_04880	COG0254	rRNA binding
HL663_04895	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HL663_04900	COG0776	regulation of translation
HL663_04910	COG0745	RESPONSE REGULATOR receiver
HL663_04915	COG2205	protein histidine kinase activity
HL663_04925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HL663_04930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HL663_04935	COG1937	Protein conserved in bacteria
HL663_04960	COG2226	methyltransferase
HL663_04985	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HL663_04995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL663_05005	COG1137	ATPase activity
HL663_05035	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_05060	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HL663_05060	COG0517	IMP dehydrogenase activity
HL663_05075	COG0583	DNA-binding transcription factor activity
HL663_05105	COG2409	Drug exporters of the RND superfamily
HL663_05135	COG0456	acetyltransferase
HL663_05185	COG2814	Major facilitator Superfamily
HL663_05190	COG1902	pentaerythritol trinitrate reductase activity
HL663_05195	COG1942	4-Oxalocrotonate Tautomerase
HL663_05200	COG1024	Enoyl-CoA hydratase
HL663_05205	COG0243	molybdopterin cofactor binding
HL663_05215	COG1960	acyl-CoA dehydrogenase activity
HL663_05235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL663_05250	COG0456	acetyltransferase
HL663_05260	COG2072	flavoprotein involved in K transport
HL663_05265	COG3268	Saccharopine dehydrogenase
HL663_05270	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HL663_05275	COG1070	Carbohydrate kinase
HL663_05280	COG2390	Transcriptional regulator
HL663_05285	COG2755	lipolytic protein G-D-S-L family
HL663_05305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL663_05325	COG1063	alcohol dehydrogenase
HL663_05355	COG3655	Transcriptional regulator
HL663_05380	COG0577	efflux transmembrane transporter activity
HL663_05380	COG1136	(ABC) transporter
HL663_05400	COG0604	alcohol dehydrogenase
HL663_05410	COG4565	transcriptional regulatory protein
HL663_05415	COG3290	protein histidine kinase activity
HL663_05435	COG0589	response to stress
HL663_05440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HL663_05450	COG1132	(ABC) transporter
HL663_05465	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HL663_05470	COG0442	prolyl-tRNA aminoacylation
HL663_05485	COG1228	amidohydrolase
HL663_05495	COG4721	ABC-type cobalt transport system, permease component
HL663_05500	COG1122	ATPase activity
HL663_05505	COG0477	Major facilitator Superfamily
HL663_05515	COG0477	Major facilitator Superfamily
HL663_05520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL663_05525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HL663_05560	COG1072	(Pantothenic acid kinase))
HL663_05575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_05595	COG0443	Heat shock 70 kDa protein
HL663_05600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HL663_05605	COG0484	heat shock protein binding
HL663_05610	COG0789	Transcriptional regulator
HL663_05635	COG0542	response to heat
HL663_05645	COG0477	Major facilitator Superfamily
HL663_05655	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HL663_05690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HL663_05695	COG1704	LemA family
HL663_05705	COG0842	Transport permease protein
HL663_05710	COG4585	Histidine kinase
HL663_05715	COG2197	response regulator
HL663_05720	COG0586	Pfam SNARE associated Golgi protein
HL663_05730	COG0765	amino acid transport
HL663_05745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_05755	COG3795	YCII-related domain
HL663_05785	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HL663_05790	COG2201	protein-glutamate methylesterase activity
HL663_05795	COG0745	RESPONSE REGULATOR receiver
HL663_05800	COG0840	transmembrane signaling receptor activity
HL663_05810	COG2198	Histidine kinase
HL663_05810	COG0784	Response regulator, receiver
HL663_05810	COG0643	Histidine kinase
HL663_05830	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HL663_05835	COG3973	AAA domain
HL663_05840	COG0151	Belongs to the GarS family
HL663_05845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_05860	COG2814	Major facilitator Superfamily
HL663_05870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HL663_05890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HL663_05890	COG0047	phosphoribosylformylglycinamidine synthase activity
HL663_05905	COG2080	2 iron, 2 sulfur cluster binding
HL663_05910	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HL663_05915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HL663_05930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_05940	COG1595	DNA-templated transcription, initiation
HL663_05950	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HL663_05970	COG0531	amino acid
HL663_05985	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HL663_05990	COG0590	tRNA wobble adenosine to inosine editing
HL663_06005	COG0586	Pfam SNARE associated Golgi protein
HL663_06020	COG0433	COG0433 Predicted ATPase
HL663_06045	COG2755	lipolytic protein G-D-S-L family
HL663_06045	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL663_06060	COG1472	Belongs to the glycosyl hydrolase 3 family
HL663_06065	COG3876	Protein conserved in bacteria
HL663_06070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HL663_06075	COG1737	Transcriptional regulator
HL663_06080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HL663_06090	COG1175	transmembrane transport
HL663_06095	COG0395	ABC-type sugar transport system, permease component
HL663_06120	COG2409	Drug exporters of the RND superfamily
HL663_06150	COG1116	anion transmembrane transporter activity
HL663_06170	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HL663_06215	COG2197	response regulator
HL663_06245	COG1794	racemase activity, acting on amino acids and derivatives
HL663_06270	COG1349	DNA-binding transcription factor activity
HL663_06310	COG1940	carbohydrate kinase activity
HL663_06315	COG3158	transport of potassium into the cell
HL663_06325	COG1408	metallophosphoesterase
HL663_06335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HL663_06345	COG0003	Pfam Anion-transporting ATPase
HL663_06375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL663_06405	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HL663_06410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HL663_06425	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HL663_06435	COG1063	alcohol dehydrogenase
HL663_06440	COG0156	8-amino-7-oxononanoate synthase activity
HL663_06445	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HL663_06460	COG3275	phosphorelay sensor kinase activity
HL663_06515	COG1111	helicase
HL663_06515	COG1205	dead DEAH box helicase
HL663_06520	COG1366	Belongs to the anti-sigma-factor antagonist family
HL663_06525	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HL663_06530	COG2890	protein-(glutamine-N5) methyltransferase activity
HL663_06545	COG0745	RESPONSE REGULATOR receiver
HL663_06550	COG5002	protein histidine kinase activity
HL663_06575	COG2755	lipolytic protein G-D-S-L family
HL663_06575	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL663_06580	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL663_06580	COG2755	lipolytic protein G-D-S-L family
HL663_06620	COG3384	dioxygenase
HL663_06625	COG2197	response regulator
HL663_06630	COG4585	Histidine kinase
HL663_06650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HL663_06650	COG1754	DNA topoisomerase type I activity
HL663_06665	COG0789	Transcriptional regulator
HL663_06685	COG2197	response regulator
HL663_06690	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HL663_06695	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HL663_06730	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HL663_06745	COG0037	tRNA processing
HL663_06760	COG0302	gtp cyclohydrolase
HL663_06765	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HL663_06770	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HL663_06780	COG0649	NAD binding
HL663_06800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HL663_06805	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HL663_06820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HL663_06830	COG2226	methyltransferase
HL663_06840	COG0248	Ppx GppA phosphatase
HL663_06845	COG1082	Xylose isomerase domain protein TIM barrel
HL663_06855	COG2205	protein histidine kinase activity
HL663_06860	COG0745	RESPONSE REGULATOR receiver
HL663_06875	COG0506	proline dehydrogenase activity
HL663_06880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HL663_06895	COG0569	domain protein
HL663_06900	COG0123	including yeast histone deacetylase and acetoin utilization protein
HL663_06930	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HL663_06935	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HL663_06940	COG0181	hydroxymethylbilane synthase activity
HL663_06945	COG1648	precorrin-2 dehydrogenase activity
HL663_06945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HL663_06950	COG0113	porphobilinogen synthase activity
HL663_06960	COG2353	YceI-like domain
HL663_06970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HL663_06975	COG0406	alpha-ribazole phosphatase activity
HL663_06985	COG0785	Cytochrome C biogenesis protein
HL663_06995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HL663_07025	COG2031	fatty acid transporter
HL663_07040	COG4948	Mandelate Racemase Muconate Lactonizing
HL663_07070	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HL663_07075	COG0644	oxidoreductase
HL663_07080	COG1169	isochorismate synthase
HL663_07085	COG2226	methyltransferase
HL663_07095	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL663_07100	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL663_07105	COG0649	NAD binding
HL663_07120	COG1034	ATP synthesis coupled electron transport
HL663_07125	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HL663_07130	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL663_07135	COG0839	Belongs to the complex I subunit 6 family
HL663_07165	COG2271	Major facilitator Superfamily
HL663_07180	COG2161	toxin-antitoxin pair type II binding
HL663_07185	COG2026	Addiction module toxin, RelE StbE family
HL663_07205	COG0596	Alpha beta hydrolase
HL663_07225	COG1013	pyruvate-flavodoxin oxidoreductase activity
HL663_07230	COG0674	pyruvate-flavodoxin oxidoreductase activity
HL663_07230	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HL663_07250	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL663_07255	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL663_07275	COG0714	Associated with various cellular activities
HL663_07295	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL663_07300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HL663_07305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL663_07315	COG0713	ATP synthesis coupled electron transport
HL663_07320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HL663_07325	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL663_07330	COG1007	ATP synthesis coupled electron transport
HL663_07335	COG0501	Belongs to the peptidase M48B family
HL663_07340	COG0363	glucosamine-6-phosphate deaminase activity
HL663_07355	COG1404	Belongs to the peptidase S8 family
HL663_07365	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HL663_07370	COG1666	GTP binding
HL663_07390	COG0439	Biotin carboxylase
HL663_07400	COG3214	Protein conserved in bacteria
HL663_07410	COG2149	membrane
HL663_07420	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HL663_07455	COG0446	pyridine nucleotide-disulphide oxidoreductase
HL663_07470	COG0745	RESPONSE REGULATOR receiver
HL663_07475	COG5002	protein histidine kinase activity
HL663_07485	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HL663_07490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HL663_07490	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HL663_07490	COG1703	isobutyryl-CoA mutase activity
HL663_07535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HL663_07540	COG2030	dehydratase
HL663_07550	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HL663_07560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HL663_07570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL663_07585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HL663_07595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HL663_07600	COG0081	regulation of translation
HL663_07610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HL663_07615	COG0222	ribosome binding
HL663_07630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HL663_07655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HL663_07675	COG0085	RNA polymerase activity
HL663_07680	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HL663_07695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HL663_07700	COG0049	tRNA binding
HL663_07705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HL663_07710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HL663_07720	COG0697	spore germination
HL663_07735	COG0051	transcription antitermination factor activity, RNA binding
HL663_07740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HL663_07745	COG0088	Forms part of the polypeptide exit tunnel
HL663_07750	COG0089	rRNA binding
HL663_07755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HL663_07760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HL663_07765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HL663_07770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HL663_07775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HL663_07780	COG0255	Belongs to the universal ribosomal protein uL29 family
HL663_07785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HL663_07790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HL663_07795	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HL663_07800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HL663_07810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HL663_07815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HL663_07825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HL663_07830	COG1841	ribosomal large subunit assembly
HL663_07835	COG0200	Binds to the 23S rRNA
HL663_07845	COG0563	adenylate kinase activity
HL663_07875	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HL663_07880	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HL663_07885	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HL663_07890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HL663_07900	COG0202	RNA polymerase activity
HL663_07905	COG0203	ribosomal protein L17
HL663_07910	COG0101	tRNA pseudouridine synthase activity
HL663_07970	COG0535	radical SAM domain protein
HL663_08015	COG2197	response regulator
HL663_08055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HL663_08060	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HL663_08065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HL663_08070	COG1764	response to oxidative stress
HL663_08075	COG0579	oxidoreductase
HL663_08080	COG2723	6-phospho-beta-galactosidase activity
HL663_08095	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HL663_08095	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HL663_08125	COG3226	Transcriptional regulator
HL663_08130	COG1570	exodeoxyribonuclease VII activity
HL663_08135	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HL663_08145	COG1322	Protein conserved in bacteria
HL663_08150	COG0386	Belongs to the glutathione peroxidase family
HL663_08165	COG0012	GTP binding
HL663_08180	COG0714	Associated with various cellular activities
HL663_08220	COG1404	Belongs to the peptidase S8 family
HL663_08230	COG0745	RESPONSE REGULATOR receiver
HL663_08235	COG0589	response to stress
HL663_08240	COG2755	lipolytic protein G-D-S-L family
HL663_08245	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HL663_08270	COG0505	Belongs to the CarA family
HL663_08280	COG2154	pterin-4-alpha-carbinolamine dehydratase
HL663_08285	COG4608	Belongs to the ABC transporter superfamily
HL663_08290	COG0444	Belongs to the ABC transporter superfamily
HL663_08300	COG0601	transmembrane transport
HL663_08305	COG0747	negative chemotaxis
HL663_08315	COG0747	negative chemotaxis
HL663_08320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HL663_08325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HL663_08330	COG2720	vancomycin resistance protein
HL663_08335	COG0456	acetyltransferase
HL663_08370	COG1611	Belongs to the LOG family
HL663_08410	COG1595	DNA-templated transcription, initiation
HL663_08420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL663_08440	COG2239	Acts as a magnesium transporter
HL663_08455	COG2301	Belongs to the HpcH HpaI aldolase family
HL663_08470	COG0673	inositol 2-dehydrogenase activity
HL663_08505	COG0006	proline dipeptidase activity
HL663_08520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HL663_08545	COG0613	PHP domain protein
HL663_08550	COG2095	MarC family integral membrane protein
HL663_08555	COG2205	protein histidine kinase activity
HL663_08600	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HL663_08610	COG1012	belongs to the aldehyde dehydrogenase family
HL663_08615	COG1760	l-serine dehydratase
HL663_08625	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HL663_08640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HL663_08650	COG4176	ABC-type proline glycine betaine transport system permease component
HL663_08655	COG0517	IMP dehydrogenase activity
HL663_08655	COG4175	Glycine betaine
HL663_08660	COG1414	Transcriptional regulator
HL663_08665	COG5598	trimethylamine methyltransferase
HL663_08675	COG5012	cobalamin binding
HL663_08695	COG0646	methionine synthase
HL663_08695	COG1410	methionine synthase
HL663_08715	COG0583	DNA-binding transcription factor activity
HL663_08720	COG1192	Involved in chromosome partitioning
HL663_08725	COG1064	alcohol dehydrogenase
HL663_08730	COG0513	Belongs to the DEAD box helicase family
HL663_08740	COG2261	transglycosylase associated protein
HL663_08765	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HL663_08865	COG3480	Lon protease (S16) C-terminal proteolytic domain
HL663_08875	COG1615	UPF0182 protein
HL663_08885	COG1252	NADH dehydrogenase
HL663_08890	COG0612	Peptidase, M16
HL663_08900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HL663_08905	COG0483	inositol monophosphate 1-phosphatase activity
HL663_08910	COG4166	transmembrane transport
HL663_08915	COG0601	transmembrane transport
HL663_08920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL663_08930	COG4608	Belongs to the ABC transporter superfamily
HL663_08935	COG1162	GTPase activity
HL663_08940	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HL663_08950	COG2135	peptidase activity
HL663_08960	COG1595	DNA-templated transcription, initiation
HL663_08965	COG5662	AntiSigma factor
HL663_09005	COG0765	amino acid transport
HL663_09025	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HL663_09040	COG0604	alcohol dehydrogenase
HL663_09055	COG0567	Dehydrogenase, E1 component
HL663_09055	COG0508	dehydrogenase complex catalyzes the overall conversion of
HL663_09070	COG1253	flavin adenine dinucleotide binding
HL663_09085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HL663_09095	COG0745	RESPONSE REGULATOR receiver
HL663_09100	COG0018	arginyl-trna synthetase
HL663_09110	COG0460	homoserine dehydrogenase
HL663_09115	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HL663_09120	COG0083	homoserine kinase activity
HL663_09140	COG0254	rRNA binding
HL663_09145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HL663_09150	COG2890	protein-(glutamine-N5) methyltransferase activity
HL663_09155	COG0009	L-threonylcarbamoyladenylate synthase
HL663_09160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HL663_09165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HL663_09175	COG0356	it plays a direct role in the translocation of protons across the membrane
HL663_09180	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HL663_09185	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HL663_09190	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HL663_09195	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HL663_09200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HL663_09205	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HL663_09210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HL663_09230	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HL663_09230	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HL663_09235	COG0693	protein deglycase activity
HL663_09240	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HL663_09275	COG0604	alcohol dehydrogenase
HL663_09290	COG0183	Belongs to the thiolase family
HL663_09370	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HL663_09375	COG3281	Trehalose synthase
HL663_09380	COG0366	Alpha amylase catalytic
HL663_09385	COG0366	Alpha amylase catalytic
HL663_09390	COG0058	SHG alpha-glucan phosphorylase activity
HL663_09415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HL663_09445	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HL663_09455	COG0482	sulfurtransferase activity
HL663_09480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL663_09505	COG0318	PFAM AMP-dependent synthetase and ligase
HL663_09530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HL663_09565	COG2860	membrane
HL663_09570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HL663_09575	COG0154	amidase activity
HL663_09580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HL663_09595	COG2755	lipolytic protein G-D-S-L family
HL663_09595	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL663_09605	COG2409	Drug exporters of the RND superfamily
HL663_09625	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HL663_09630	COG0129	dihydroxy-acid dehydratase activity
HL663_09655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HL663_09660	COG0028	Belongs to the TPP enzyme family
HL663_09665	COG0440	acetolactate synthase activity
HL663_09670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HL663_09680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL663_09695	COG0473	3-isopropylmalate dehydrogenase activity
HL663_09700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HL663_09705	COG0531	amino acid
HL663_09725	COG0174	glutamine synthetase
HL663_09730	COG1012	belongs to the aldehyde dehydrogenase family
HL663_09735	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_09740	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HL663_09760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HL663_09815	COG0179	Fumarylacetoacetate (FAA) hydrolase
HL663_09830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HL663_09865	COG1414	Transcriptional regulator
HL663_09870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HL663_09875	COG0066	3-isopropylmalate dehydratase activity
HL663_09880	COG0776	regulation of translation
HL663_09885	COG1920	GTP binding
HL663_09895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HL663_09905	COG1181	Belongs to the D-alanine--D-alanine ligase family
HL663_09925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HL663_09930	COG1461	Dihydroxyacetone kinase
HL663_09935	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HL663_09940	COG0742	ribosomal rna small subunit methyltransferase
HL663_09950	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HL663_09955	COG2755	lipolytic protein G-D-S-L family
HL663_09955	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL663_09965	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HL663_09970	COG0571	ribonuclease III activity
HL663_09975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HL663_09980	COG2755	lipolytic protein G-D-S-L family
HL663_09980	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL663_09990	COG1605	Chorismate mutase
HL663_09990	COG0287	Prephenate dehydrogenase
HL663_10005	COG0681	Belongs to the peptidase S26 family
HL663_10015	COG3590	peptidase
HL663_10040	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HL663_10050	COG2267	carboxylic ester hydrolase activity
HL663_10060	COG0730	response to heat
HL663_10070	COG0228	four-way junction DNA binding
HL663_10075	COG1837	Belongs to the UPF0109 family
HL663_10080	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HL663_10085	COG0336	Belongs to the RNA methyltransferase TrmD family
HL663_10090	COG0390	transport system, permease component
HL663_10095	COG0335	large ribosomal subunit rRNA binding
HL663_10105	COG0681	Belongs to the peptidase S26 family
HL663_10110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HL663_10120	COG1012	belongs to the aldehyde dehydrogenase family
HL663_10125	COG0792	nuclease activity
HL663_10140	COG4974	Belongs to the 'phage' integrase family
HL663_10160	COG0052	Belongs to the universal ribosomal protein uS2 family
HL663_10165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HL663_10175	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HL663_10180	COG0528	UMP kinase activity
HL663_10185	COG0233	cytoplasmic translational termination
HL663_10200	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HL663_10215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HL663_10220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HL663_10230	COG1012	belongs to the aldehyde dehydrogenase family
HL663_10240	COG3842	ATPase activity
HL663_10245	COG1176	ABC-type spermidine putrescine transport system, permease component I
HL663_10250	COG1177	transmembrane transport
HL663_10270	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HL663_10275	COG0750	zinc metalloprotease
HL663_10285	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HL663_10300	COG4213	ABC transporter substrate-binding protein
HL663_10305	COG4214	carbohydrate transport
HL663_10310	COG1129	ABC transporter
HL663_10320	COG0442	prolyl-tRNA aminoacylation
HL663_10360	COG1331	Highly conserved protein containing a thioredoxin domain
HL663_10375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HL663_10390	COG3842	ATPase activity
HL663_10395	COG2010	Cytochrome c
HL663_10395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HL663_10415	COG0779	Required for maturation of 30S ribosomal subunits
HL663_10430	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HL663_10430	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HL663_10450	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HL663_10455	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HL663_10465	COG0772	Belongs to the SEDS family
HL663_10470	COG1022	Amp-dependent synthetase and ligase
HL663_10485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HL663_10520	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HL663_10530	COG1530	ribonuclease E activity
HL663_10535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HL663_10540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HL663_10545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HL663_10550	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HL663_10555	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HL663_10560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HL663_10565	COG0463	Glycosyl transferase, family 2
HL663_10575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HL663_10580	COG0799	negative regulation of ribosome biogenesis
HL663_10585	COG0588	phosphoglycerate mutase activity
HL663_10600	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HL663_10605	COG2818	Glycosylase
HL663_10610	COG1408	metallophosphoesterase
HL663_10615	COG0386	Belongs to the glutathione peroxidase family
HL663_10640	COG0495	leucyl-tRNA aminoacylation
HL663_10645	COG3842	ATPase activity
HL663_10655	COG1176	ABC-type spermidine putrescine transport system, permease component I
HL663_10660	COG1177	transmembrane transport
HL663_10665	COG1228	amidohydrolase
HL663_10670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HL663_10705	COG2205	protein histidine kinase activity
HL663_10720	COG1307	EDD domain protein, DegV family
HL663_10725	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HL663_10730	COG1596	polysaccharide export
HL663_10730	COG1555	photosystem II stabilization
HL663_10740	COG0583	DNA-binding transcription factor activity
HL663_10745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HL663_10750	COG1247	-acetyltransferase
HL663_10755	COG0569	domain protein
HL663_10755	COG0189	ligase activity
HL663_10760	COG4067	protein conserved in archaea
HL663_10760	COG0189	ligase activity
HL663_10770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HL663_10785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HL663_10800	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HL663_10805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HL663_10830	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HL663_10830	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HL663_10880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HL663_10885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HL663_10885	COG1199	ATP-dependent helicase activity
HL663_11065	COG0667	Aldo Keto reductase
HL663_11085	COG0702	epimerase
HL663_11090	COG1733	regulation of RNA biosynthetic process
HL663_11125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HL663_11130	COG2267	carboxylic ester hydrolase activity
HL663_11150	COG0667	Aldo Keto reductase
HL663_11170	COG1643	Atp-dependent helicase
HL663_11190	COG3339	Conserved Protein
HL663_11200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HL663_11205	COG0589	response to stress
HL663_11210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HL663_11215	COG1305	Transglutaminase-like
HL663_11225	COG0714	Associated with various cellular activities
HL663_11230	COG2001	Belongs to the MraZ family
HL663_11235	COG0275	rRNA processing
HL663_11245	COG0768	penicillin binding
HL663_11250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HL663_11260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HL663_11265	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HL663_11275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HL663_11280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HL663_11285	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HL663_11290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HL663_11300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HL663_11305	COG1799	cell septum assembly
HL663_11315	COG3599	regulation of cell shape
HL663_11325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HL663_11335	COG0587	DNA-directed DNA polymerase activity
HL663_11340	COG4085	toxin activity
HL663_11340	COG1525	nuclease
HL663_11340	COG0737	Belongs to the 5'-nucleotidase family
HL663_11360	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HL663_11360	COG0235	Class ii aldolase
HL663_11390	COG0640	Transcriptional regulator
HL663_11400	COG0746	molybdenum cofactor guanylyltransferase activity
HL663_11415	COG0438	transferase activity, transferring glycosyl groups
HL663_11425	COG1132	(ABC) transporter
HL663_11450	COG1609	Transcriptional regulator
HL663_11455	COG3250	beta-galactosidase activity
HL663_11465	COG2508	Transcriptional regulator
HL663_11470	COG2072	flavoprotein involved in K transport
HL663_11475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HL663_11485	COG2186	Transcriptional regulator
HL663_11495	COG1070	Carbohydrate kinase
HL663_11500	COG3347	Dehydrogenase
HL663_11500	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_11515	COG0174	glutamine synthetase
HL663_11530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HL663_11535	COG0321	lipoyl(octanoyl) transferase activity
HL663_11540	COG2409	Drug exporters of the RND superfamily
HL663_11545	COG0673	inositol 2-dehydrogenase activity
HL663_11550	COG3340	Belongs to the peptidase S51 family
HL663_11560	COG1090	epimerase
HL663_11565	COG0508	dehydrogenase complex catalyzes the overall conversion of
HL663_11570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HL663_11585	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HL663_11590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HL663_11610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL663_11615	COG0435	Glutathione S-transferase
HL663_11630	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HL663_11635	COG2318	DinB family
HL663_11640	COG1929	Belongs to the glycerate kinase type-1 family
HL663_11650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL663_11655	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HL663_11660	COG0425	Belongs to the sulfur carrier protein TusA family
HL663_11665	COG1104	cysteine desulfurase activity
HL663_11670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HL663_11675	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HL663_11695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HL663_11700	COG0723	plastoquinol--plastocyanin reductase activity
HL663_11705	COG2010	Cytochrome c
HL663_11710	COG1845	cytochrome c oxidase, subunit III
HL663_11715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HL663_11760	COG1022	Amp-dependent synthetase and ligase
HL663_11810	COG2197	response regulator
HL663_11815	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HL663_11835	COG3942	CHAP domain
HL663_11835	COG1388	LysM domain
HL663_11880	COG0587	DNA-directed DNA polymerase activity
HL663_11890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HL663_11910	COG0187	DNA topoisomerase II activity
HL663_11920	COG1609	Transcriptional regulator
HL663_11925	COG0395	ABC-type sugar transport system, permease component
HL663_11930	COG1175	transmembrane transport
HL663_11935	COG1653	transport
HL663_11940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HL663_11950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HL663_11950	COG1042	CoA-binding domain protein
HL663_11950	COG0045	succinate-CoA ligase (ADP-forming) activity
HL663_11965	COG1435	thymidine kinase activity
HL663_12015	COG0569	domain protein
HL663_12020	COG0531	amino acid
HL663_12025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HL663_12035	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HL663_12040	COG0395	ABC-type sugar transport system, permease component
HL663_12045	COG1175	transmembrane transport
HL663_12055	COG1609	Transcriptional regulator
HL663_12065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HL663_12075	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HL663_12125	COG0346	lactoylglutathione lyase activity
HL663_12175	COG1733	regulation of RNA biosynthetic process
HL663_12205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HL663_12210	COG1250	3-hydroxyacyl-CoA dehydrogenase
HL663_12210	COG1024	Enoyl-CoA hydratase
HL663_12215	COG0183	Belongs to the thiolase family
HL663_12240	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HL663_12275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HL663_12280	COG1793	dna ligase
HL663_12295	COG2326	polyphosphate kinase activity
HL663_12400	COG3842	ATPase activity
HL663_12405	COG4208	sulfate ABC transporter
HL663_12420	COG5001	Diguanylate cyclase
HL663_12445	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HL663_12450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HL663_12450	COG0512	Glutamine amidotransferase of anthranilate synthase
HL663_12480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HL663_12490	COG0183	Belongs to the thiolase family
HL663_12525	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HL663_12540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HL663_12565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HL663_12575	COG0438	transferase activity, transferring glycosyl groups
HL663_12585	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HL663_12590	COG0477	Major facilitator Superfamily
HL663_12600	COG3706	GGDEF domain
HL663_12610	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HL663_12615	COG0217	transcriptional regulatory protein
HL663_12620	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HL663_12625	COG0632	four-way junction helicase activity
HL663_12630	COG2255	four-way junction helicase activity
HL663_12640	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HL663_12645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HL663_12650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HL663_12655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HL663_12660	COG1196	nuclear chromosome segregation
HL663_12665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HL663_12675	COG0124	histidyl-tRNA synthetase
HL663_12685	COG0686	Belongs to the AlaDH PNT family
HL663_12700	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HL663_12705	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HL663_12720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HL663_12725	COG1160	GTP binding
HL663_12735	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HL663_12765	COG1716	ATPase activity
HL663_12785	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HL663_12785	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HL663_12790	COG0419	ATPase involved in DNA repair
HL663_12795	COG0420	3'-5' exonuclease activity
HL663_12805	COG0406	alpha-ribazole phosphatase activity
HL663_12815	COG0009	L-threonylcarbamoyladenylate synthase
HL663_12825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HL663_12840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HL663_12870	COG1216	Glycosyl transferase, family 2
HL663_12880	COG1607	acyl-coa hydrolase
HL663_12885	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HL663_12890	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HL663_12895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HL663_12930	COG0604	alcohol dehydrogenase
HL663_12935	COG1509	lysine 2,3-aminomutase activity
HL663_12940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HL663_12950	COG0492	ferredoxin-NADP+ reductase activity
HL663_12955	COG1522	sequence-specific DNA binding
HL663_12960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HL663_12990	COG0805	protein transport
HL663_12995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HL663_13005	COG2378	regulation of single-species biofilm formation
HL663_13030	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HL663_13035	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HL663_13040	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HL663_13050	COG4122	O-methyltransferase activity
HL663_13060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HL663_13075	COG1222	aaa ATPase
HL663_13085	COG1994	Peptidase M50
HL663_13085	COG0517	IMP dehydrogenase activity
HL663_13090	COG0646	methionine synthase
HL663_13090	COG1410	methionine synthase
HL663_13100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL663_13110	COG0215	cysteine-tRNA ligase activity
HL663_13125	COG1122	ATPase activity
HL663_13145	COG0588	phosphoglycerate mutase activity
HL663_13150	COG0598	Magnesium transport protein CorA
HL663_13155	COG1968	undecaprenyl-diphosphatase activity
HL663_13160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_13170	COG1090	epimerase
HL663_13175	COG0667	Aldo Keto reductase
HL663_13190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL663_13200	COG0515	serine threonine protein kinase
HL663_13215	COG0784	Response regulator, receiver
HL663_13215	COG2205	protein histidine kinase activity
HL663_13230	COG0745	RESPONSE REGULATOR receiver
HL663_13260	COG1119	ATPase activity
HL663_13270	COG0297	glycogen (starch) synthase activity
HL663_13295	COG0560	Phosphoserine phosphatase
HL663_13295	COG3830	Belongs to the UPF0237 family
HL663_13305	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_13315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HL663_13330	COG1132	(ABC) transporter
HL663_13335	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HL663_13340	COG0488	(ABC) transporter
HL663_13370	COG2151	metal-sulfur cluster biosynthetic enzyme
HL663_13375	COG0822	iron-sulfur transferase activity
HL663_13385	COG0396	ATPase activity
HL663_13410	COG1183	phosphatidylcholine synthase activity
HL663_13440	COG0109	protoheme IX farnesyltransferase activity
HL663_13450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HL663_13455	COG0166	Belongs to the GPI family
HL663_13470	COG0363	glucosamine-6-phosphate deaminase activity
HL663_13485	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HL663_13490	COG0149	triose-phosphate isomerase activity
HL663_13495	COG0126	phosphoglycerate kinase activity
HL663_13500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HL663_13505	COG1481	regulation of sporulation
HL663_13510	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HL663_13515	COG1660	Displays ATPase and GTPase activities
HL663_13520	COG0322	excinuclease ABC activity
HL663_13560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HL663_13565	COG3387	PFAM Glycoside hydrolase 15-related
HL663_13575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL663_13580	COG5006	permease, DMT superfamily
HL663_13590	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HL663_13605	COG0667	Aldo Keto reductase
HL663_13610	COG0556	nucleotide-excision repair
HL663_13615	COG1940	carbohydrate kinase activity
HL663_13630	COG3833	ABC-type maltose transport systems, permease component
HL663_13640	COG0531	amino acid
HL663_13645	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HL663_13645	COG0237	dephospho-CoA kinase activity
HL663_13660	COG3467	pyridoxamine 5'-phosphate
HL663_13665	COG3842	ATPase activity
HL663_13675	COG0395	ABC-type sugar transport system, permease component
HL663_13685	COG0539	negative regulation of cytoplasmic translation
HL663_13690	COG2226	methyltransferase
HL663_13710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HL663_13750	COG2050	protein possibly involved in aromatic compounds catabolism
HL663_13780	COG0469	pyruvate kinase activity
HL663_13790	COG0067	glutamate synthase
HL663_13790	COG0070	glutamate synthase
HL663_13790	COG0069	glutamate synthase activity
HL663_13810	COG0159	tryptophan synthase activity
HL663_13815	COG0133	tryptophan synthase activity
HL663_13820	COG0134	indole-3-glycerol-phosphate synthase activity
HL663_13840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HL663_13870	COG0107	imidazoleglycerol-phosphate synthase activity
HL663_13875	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HL663_13880	COG4129	membrane
HL663_13885	COG2807	transmembrane transport
HL663_13895	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HL663_13900	COG0140	phosphoribosyl-ATP diphosphatase activity
HL663_13905	COG3201	nicotinamide mononucleotide transporter
HL663_13910	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HL663_13915	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HL663_13915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HL663_13935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HL663_13955	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HL663_13965	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HL663_13985	COG1758	RNA polymerase activity
HL663_13990	COG0194	GDP metabolic process
HL663_14000	COG0284	orotidine-5'-phosphate decarboxylase activity
HL663_14005	COG0167	dihydroorotate dehydrogenase activity
HL663_14010	COG0543	2 iron, 2 sulfur cluster binding
HL663_14015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HL663_14020	COG0505	Belongs to the CarA family
HL663_14025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HL663_14030	COG0540	Belongs to the ATCase OTCase family
HL663_14035	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HL663_14060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HL663_14065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HL663_14075	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HL663_14080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HL663_14085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HL663_14095	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HL663_14100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HL663_14105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HL663_14110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HL663_14145	COG2267	carboxylic ester hydrolase activity
HL663_14150	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HL663_14170	COG3012	SEC-C Motif Domain Protein
HL663_14180	COG0504	CTP synthase activity
HL663_14210	COG0497	DNA recombination
HL663_14215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HL663_14235	COG0647	UMP catabolic process
HL663_14260	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HL663_14265	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HL663_14270	COG2094	Belongs to the DNA glycosylase MPG family
HL663_14275	COG0165	Argininosuccinate lyase
HL663_14280	COG1438	arginine binding
HL663_14285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HL663_14290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HL663_14295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HL663_14300	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HL663_14310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HL663_14320	COG0072	phenylalanine-tRNA ligase activity
HL663_14320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HL663_14325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HL663_14345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL663_14350	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HL663_14355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HL663_14360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HL663_14375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HL663_14380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HL663_14390	COG0131	Imidazoleglycerol-phosphate dehydratase
HL663_14395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HL663_14400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HL663_14415	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HL663_14425	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HL663_14430	COG0174	glutamine synthetase
HL663_14450	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HL663_14470	COG1940	carbohydrate kinase activity
HL663_14525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HL663_14550	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HL663_14580	COG2267	carboxylic ester hydrolase activity
HL663_14585	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HL663_14590	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HL663_14625	COG1404	Belongs to the peptidase S8 family
HL663_14630	COG0137	argininosuccinate synthase activity
HL663_14645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HL663_14650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HL663_14655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HL663_14675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL663_14675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HL663_14685	COG0730	response to heat
HL663_14700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HL663_14710	COG1126	abc transporter atp-binding protein
HL663_14715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL663_14720	COG0765	amino acid transport
HL663_14725	COG0765	amino acid transport
HL663_14745	COG5002	protein histidine kinase activity
HL663_14750	COG0745	RESPONSE REGULATOR receiver
HL663_14755	COG5002	protein histidine kinase activity
HL663_14770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_14775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL663_14810	COG0673	inositol 2-dehydrogenase activity
HL663_14815	COG0444	Belongs to the ABC transporter superfamily
HL663_14825	COG0601	transmembrane transport
HL663_14830	COG0747	negative chemotaxis
HL663_14835	COG4608	Belongs to the ABC transporter superfamily
HL663_14845	COG0436	Aminotransferase
HL663_14850	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_14875	COG0582	viral genome integration into host DNA
HL663_14895	COG0438	transferase activity, transferring glycosyl groups
HL663_14975	COG0358	DNA primase activity
HL663_15010	COG0741	lytic transglycosylase activity
HL663_15010	COG0739	heme binding
HL663_15010	COG1196	nuclear chromosome segregation
HL663_15070	COG0741	lytic transglycosylase activity
HL663_15070	COG1388	LysM domain
HL663_15140	COG0419	ATPase involved in DNA repair
HL663_15190	COG1063	alcohol dehydrogenase
HL663_15215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL663_15265	COG0358	DNA primase activity
HL663_15270	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HL663_15320	COG1253	flavin adenine dinucleotide binding
HL663_15325	COG0423	glycine-tRNA ligase activity
HL663_15335	COG0803	Belongs to the bacterial solute-binding protein 9 family
HL663_15340	COG1121	(ABC) transporter
HL663_15345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HL663_15355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HL663_15360	COG1381	Involved in DNA repair and RecF pathway recombination
HL663_15400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HL663_15410	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HL663_15435	COG2197	response regulator
HL663_15455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HL663_15465	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HL663_15475	COG0537	adenosine 5'-monophosphoramidase activity
HL663_15500	COG0484	heat shock protein binding
HL663_15505	COG1420	regulation of RNA biosynthetic process
HL663_15540	COG1051	belongs to the nudix hydrolase family
HL663_15555	COG3629	intracellular signal transduction
HL663_15570	COG2197	response regulator
HL663_15575	COG2132	Multicopper oxidase
HL663_15600	COG0481	GTPase activity
HL663_15625	COG0268	Binds directly to 16S ribosomal RNA
HL663_15655	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HL663_15665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HL663_15670	COG2813	Specifically methylates the guanine in position
HL663_15675	COG0405	Gamma-glutamyltransferase
HL663_15680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HL663_15685	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HL663_15690	COG0242	peptide deformylase activity
HL663_15705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL663_15715	COG1305	Transglutaminase-like
HL663_15735	COG1278	Cold shock
HL663_15755	COG3304	Inner membrane component domain
HL663_15765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HL663_15815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HL663_15820	COG2957	Belongs to the agmatine deiminase family
HL663_15840	COG1201	RNA secondary structure unwinding
HL663_15845	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HL663_15850	COG1396	sequence-specific DNA binding
HL663_15855	COG1546	Belongs to the CinA family
HL663_15855	COG1058	Belongs to the CinA family
HL663_15865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL663_15880	COG1674	ftsk spoiiie
HL663_15885	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HL663_15890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HL663_15895	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HL663_15935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HL663_15935	COG1648	precorrin-2 dehydrogenase activity
HL663_15940	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HL663_15950	COG1185	polyribonucleotide nucleotidyltransferase activity
HL663_15955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HL663_15985	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HL663_15995	COG3383	formate dehydrogenase (NAD+) activity
HL663_16045	COG3973	AAA domain
HL663_16045	COG3973	AAA domain
HL663_16085	COG0438	transferase activity, transferring glycosyl groups
HL663_16090	COG0463	Glycosyl transferase, family 2
HL663_16095	COG0110	maltose O-acetyltransferase activity
HL663_16100	COG1216	Glycosyl transferase, family 2
HL663_16125	COG0768	penicillin binding
HL663_16145	COG0105	UTP biosynthetic process
HL663_16160	COG1131	(ABC) transporter
HL663_16170	COG4585	Histidine kinase
HL663_16175	COG2197	response regulator
HL663_16180	COG0285	dihydrofolate synthase activity
HL663_16225	COG3845	ABC transporter
HL663_16250	COG0204	Acyl-transferase
HL663_16255	COG1674	ftsk spoiiie
HL663_16300	COG1404	Belongs to the peptidase S8 family
HL663_16305	COG0525	valine-tRNA ligase activity
HL663_16330	COG0714	Associated with various cellular activities
HL663_16345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HL663_16360	COG0740	serine-type endopeptidase activity
HL663_16365	COG0740	serine-type endopeptidase activity
HL663_16370	COG0738	Major facilitator superfamily
HL663_16375	COG1609	Transcriptional regulator
HL663_16380	COG0544	peptidyl-prolyl cis-trans isomerase activity
HL663_16400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HL663_16410	COG0698	ribose 5-phosphate isomerase
HL663_16415	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HL663_16425	COG0668	transmembrane transport
HL663_16435	COG0366	Alpha amylase catalytic
HL663_16465	COG0514	ATP-dependent DNA helicase (RecQ)
HL663_16475	COG0477	Major facilitator Superfamily
HL663_16485	COG2364	Membrane
HL663_16490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL663_16495	COG1946	Acyl-CoA thioesterase
HL663_16500	COG1136	(ABC) transporter
HL663_16500	COG0577	efflux transmembrane transporter activity
HL663_16505	COG1136	(ABC) transporter
HL663_16540	COG1960	acyl-CoA dehydrogenase activity
HL663_16545	COG1309	transcriptional regulator
HL663_16550	COG2226	methyltransferase
HL663_16560	COG0463	Glycosyl transferase, family 2
HL663_16570	COG0629	single-stranded DNA binding
HL663_16575	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HL663_16595	COG1473	amidohydrolase
HL663_16605	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HL663_16670	COG2197	response regulator
HL663_16675	COG4585	Histidine kinase
HL663_16745	COG1742	UPF0060 membrane protein
HL663_16760	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HL663_16775	COG5640	endopeptidase activity
HL663_16785	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HL663_16790	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HL663_16795	COG1234	tRNA 3'-trailer cleavage
HL663_16800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HL663_16810	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HL663_16865	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HL663_16870	COG1522	sequence-specific DNA binding
HL663_16875	COG0737	Belongs to the 5'-nucleotidase family
HL663_16895	COG1678	Uncharacterized ACR, COG1678
HL663_16900	COG0513	Belongs to the DEAD box helicase family
HL663_16940	COG3237	CsbD-like
HL663_16950	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HL663_16960	COG2177	Part of the ABC transporter FtsEX involved in
HL663_16965	COG2884	Cell division ATP-binding protein ftsE
HL663_16980	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HL663_16990	COG3265	gluconokinase activity
HL663_16995	COG2186	Transcriptional regulator
HL663_17040	COG1674	ftsk spoiiie
HL663_17065	COG2902	Dehydrogenase
HL663_17070	COG1982	Orn Lys Arg decarboxylase major
HL663_17095	COG1012	belongs to the aldehyde dehydrogenase family
HL663_17140	COG0653	protein targeting
HL663_17155	COG2197	response regulator
HL663_17160	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HL663_17170	COG5401	PFAM Sporulation and spore germination
HL663_17175	COG5002	protein histidine kinase activity
HL663_17175	COG5000	phosphorelay sensor kinase activity
HL663_17180	COG0745	RESPONSE REGULATOR receiver
HL663_17210	COG2894	cell division
HL663_17265	COG4106	trans-aconitate 2-methyltransferase activity
HL663_17280	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HL663_17305	COG3903	Transcriptional regulator
HL663_17305	COG3629	intracellular signal transduction
HL663_17310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HL663_17355	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HL663_17360	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HL663_17360	COG0778	Nitroreductase
HL663_17380	COG0438	transferase activity, transferring glycosyl groups
HL663_17400	COG1695	Transcriptional regulator
HL663_17425	COG2385	sporulation resulting in formation of a cellular spore
HL663_17430	COG2247	cell wall binding repeat
HL663_17430	COG0860	N-Acetylmuramoyl-L-alanine amidase
HL663_17450	COG1134	teichoic acid transport
HL663_17480	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL663_17480	COG2755	lipolytic protein G-D-S-L family
HL663_17485	COG1215	transferase activity, transferring glycosyl groups
HL663_17495	COG1216	Glycosyl transferase, family 2
HL663_17510	COG1316	TRANSCRIPTIONal
HL663_17515	COG1316	TRANSCRIPTIONal
HL663_17540	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HL663_17565	COG4585	Histidine kinase
HL663_17590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_17625	COG0745	RESPONSE REGULATOR receiver
HL663_17640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HL663_17655	COG2258	MOSC domain
HL663_17665	COG1309	transcriptional regulator
HL663_17675	COG0424	maF-like protein
HL663_17690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HL663_17695	COG1960	acyl-CoA dehydrogenase activity
HL663_17710	COG3483	tryptophan 2,3-dioxygenase activity
HL663_17725	COG1609	Transcriptional regulator
HL663_17745	COG0697	spore germination
HL663_17750	COG1846	Transcriptional regulator
HL663_17755	COG4770	biotin carboxylase activity
HL663_17790	COG3842	ATPase activity
HL663_17810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HL663_17815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HL663_17820	COG1012	belongs to the aldehyde dehydrogenase family
HL663_17825	COG1012	belongs to the aldehyde dehydrogenase family
HL663_17860	COG0714	Associated with various cellular activities
HL663_17880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HL663_17880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HL663_17895	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HL663_17920	COG1131	(ABC) transporter
HL663_17940	COG0438	transferase activity, transferring glycosyl groups
HL663_17950	COG0180	Tryptophanyl-tRNA synthetase
HL663_17955	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HL663_17970	COG0529	Catalyzes the synthesis of activated sulfate
HL663_17970	COG2895	sulfate adenylyltransferase (ATP) activity
HL663_17975	COG0730	response to heat
HL663_18000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HL663_18020	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HL663_18040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HL663_18060	COG2838	Isocitrate dehydrogenase
HL663_18070	COG0039	L-malate dehydrogenase activity
HL663_18075	COG0387	Pfam Sodium calcium exchanger
HL663_18080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HL663_18085	COG1304	FMN binding
HL663_18090	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HL663_18115	COG2233	PERMEase
HL663_18155	COG2268	Band 7 protein
HL663_18185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HL663_18200	COG0549	Belongs to the carbamate kinase family
HL663_18225	COG2116	formate transmembrane transporter activity
HL663_18230	COG0138	bifunctional purine biosynthesis protein purh
HL663_18265	COG0045	succinate-CoA ligase (ADP-forming) activity
HL663_18275	COG0596	Alpha beta hydrolase
HL663_18305	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HL663_18310	COG3104	oligopeptide transport
HL663_18340	COG2197	response regulator
HL663_18370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HL663_18380	COG1362	aminopeptidase activity
HL663_18395	COG2267	carboxylic ester hydrolase activity
HL663_18400	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HL663_18400	COG0519	Catalyzes the synthesis of GMP from XMP
HL663_18420	COG1132	(ABC) transporter
HL663_18425	COG1132	(ABC) transporter
HL663_18430	COG0586	Pfam SNARE associated Golgi protein
HL663_18450	COG1012	belongs to the aldehyde dehydrogenase family
HL663_18455	COG0516	GMP reductase activity
HL663_18460	COG0477	Major facilitator Superfamily
HL663_18465	COG3191	aminopeptidase activity
HL663_18495	COG1136	(ABC) transporter
HL663_18505	COG1794	racemase activity, acting on amino acids and derivatives
HL663_18510	COG0459	protein refolding
HL663_18515	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HL663_18530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL663_18535	COG1957	nucleoside hydrolase
HL663_18550	COG2304	oxidoreductase activity
HL663_18560	COG0739	heme binding
HL663_18590	COG2226	methyltransferase
HL663_18615	COG2226	methyltransferase
HL663_18670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HL663_18680	COG1214	PFAM Peptidase M22, glycoprotease
HL663_18680	COG0456	acetyltransferase
HL663_18685	COG0802	atpase or kinase
HL663_18695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HL663_18705	COG0736	holo-[acyl-carrier-protein] synthase activity
HL663_18710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HL663_18715	COG1072	(Pantothenic acid kinase))
HL663_18725	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HL663_18730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HL663_18745	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HL663_18755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HL663_18795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HL663_18805	COG0477	Major facilitator Superfamily
HL663_18820	COG0463	Glycosyl transferase, family 2
HL663_18845	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HL663_18845	COG1473	amidohydrolase
HL663_18850	COG1902	pentaerythritol trinitrate reductase activity
HL663_18850	COG0446	pyridine nucleotide-disulphide oxidoreductase
HL663_18865	COG2755	lipolytic protein G-D-S-L family
HL663_18870	COG0251	oxidation-reduction process
HL663_18915	COG0148	phosphopyruvate hydratase activity
HL663_18920	COG2313	pseudouridylate synthase activity
HL663_18925	COG1522	sequence-specific DNA binding
HL663_18925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL663_18960	COG0438	transferase activity, transferring glycosyl groups
HL663_19025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HL663_19030	COG0193	aminoacyl-tRNA hydrolase activity
HL663_19035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HL663_19050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HL663_19055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HL663_19060	COG2814	Major facilitator Superfamily