locus-tag	class	description
NicSoilB8_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NicSoilB8_00020	COG0592	DNA-directed DNA polymerase activity
NicSoilB8_00030	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NicSoilB8_00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NicSoilB8_00050	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
NicSoilB8_00060	COG0187	DNA topoisomerase II activity
NicSoilB8_00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NicSoilB8_00080	COG3266	domain, Protein
NicSoilB8_00110	COG1215	transferase activity, transferring glycosyl groups
NicSoilB8_00140	COG0705	Rhomboid family
NicSoilB8_00150	COG0519	Catalyzes the synthesis of GMP from XMP
NicSoilB8_00190	COG0515	serine threonine protein kinase
NicSoilB8_00200	COG0515	serine threonine protein kinase
NicSoilB8_00210	COG0768	penicillin binding
NicSoilB8_00240	COG1716	ATPase activity
NicSoilB8_00250	COG1716	ATPase activity
NicSoilB8_00270	COG1116	anion transmembrane transporter activity
NicSoilB8_00290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NicSoilB8_00440	COG0831	urea catabolic process
NicSoilB8_00450	COG0832	Belongs to the urease beta subunit family
NicSoilB8_00460	COG0804	urea catabolic process
NicSoilB8_00470	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NicSoilB8_00480	COG0830	nickel cation binding
NicSoilB8_00490	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NicSoilB8_00500	COG0829	nickel cation binding
NicSoilB8_00510	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
NicSoilB8_00520	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NicSoilB8_00560	COG0395	ABC-type sugar transport system, permease component
NicSoilB8_00570	COG1175	transmembrane transport
NicSoilB8_00590	COG1609	Transcriptional regulator
NicSoilB8_00600	COG2186	Transcriptional regulator
NicSoilB8_00610	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NicSoilB8_00620	COG0477	Major facilitator Superfamily
NicSoilB8_00630	COG1984	allophanate hydrolase subunit 2
NicSoilB8_00640	COG4770	biotin carboxylase activity
NicSoilB8_00680	COG0402	S-adenosylhomocysteine deaminase activity
NicSoilB8_00690	COG4608	Belongs to the ABC transporter superfamily
NicSoilB8_00700	COG0444	Belongs to the ABC transporter superfamily
NicSoilB8_00710	COG0601	transmembrane transport
NicSoilB8_00730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NicSoilB8_00750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NicSoilB8_00770	COG0583	DNA-binding transcription factor activity
NicSoilB8_00880	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NicSoilB8_00890	COG0574	Belongs to the PEP-utilizing enzyme family
NicSoilB8_00890	COG3848	Pyruvate phosphate dikinase
NicSoilB8_00930	COG2814	Major facilitator Superfamily
NicSoilB8_00940	COG1280	lysine exporter protein (LysE YggA)
NicSoilB8_00970	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_01010	COG2814	Major facilitator Superfamily
NicSoilB8_01080	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NicSoilB8_01100	COG0069	glutamate synthase activity
NicSoilB8_01140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilB8_01160	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilB8_01170	COG0596	Alpha beta hydrolase
NicSoilB8_01200	COG1802	Transcriptional regulator
NicSoilB8_01230	COG0196	riboflavin kinase activity
NicSoilB8_01290	COG3458	cephalosporin-C deacetylase activity
NicSoilB8_01320	COG0363	glucosamine-6-phosphate deaminase activity
NicSoilB8_01330	COG0402	S-adenosylhomocysteine deaminase activity
NicSoilB8_01340	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
NicSoilB8_01350	COG1940	carbohydrate kinase activity
NicSoilB8_01360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NicSoilB8_01370	COG4608	Belongs to the ABC transporter superfamily
NicSoilB8_01380	COG0444	Belongs to the ABC transporter superfamily
NicSoilB8_01420	COG1760	l-serine dehydratase
NicSoilB8_01470	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NicSoilB8_01480	COG1802	Transcriptional regulator
NicSoilB8_01530	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilB8_01540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NicSoilB8_01560	COG2271	Major facilitator Superfamily
NicSoilB8_01570	COG1802	Transcriptional regulator
NicSoilB8_01580	COG0477	Major facilitator Superfamily
NicSoilB8_01690	COG1177	transmembrane transport
NicSoilB8_01700	COG3842	ATPase activity
NicSoilB8_01710	COG1414	Transcriptional regulator
NicSoilB8_01730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NicSoilB8_01730	COG0574	Belongs to the PEP-utilizing enzyme family
NicSoilB8_01820	COG1064	alcohol dehydrogenase
NicSoilB8_01880	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NicSoilB8_02020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilB8_02030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilB8_02050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilB8_02090	COG0765	amino acid transport
NicSoilB8_02130	COG1609	Transcriptional regulator
NicSoilB8_02140	COG0385	Bile acid
NicSoilB8_02150	COG0789	Transcriptional regulator
NicSoilB8_02160	COG0659	secondary active sulfate transmembrane transporter activity
NicSoilB8_02170	COG1609	Transcriptional regulator
NicSoilB8_02180	COG0673	inositol 2-dehydrogenase activity
NicSoilB8_02220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NicSoilB8_02240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NicSoilB8_02240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NicSoilB8_02280	COG0561	phosphatase activity
NicSoilB8_02300	COG0584	glycerophosphoryl diester phosphodiesterase
NicSoilB8_02310	COG1929	Belongs to the glycerate kinase type-1 family
NicSoilB8_02340	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_02360	COG2233	PERMEase
NicSoilB8_02370	COG1473	amidohydrolase
NicSoilB8_02380	COG0778	Nitroreductase
NicSoilB8_02440	COG3104	oligopeptide transport
NicSoilB8_02470	COG0425	Belongs to the sulfur carrier protein TusA family
NicSoilB8_02470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NicSoilB8_02500	COG1597	lipid kinase activity
NicSoilB8_02510	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NicSoilB8_02520	COG0561	phosphatase activity
NicSoilB8_02560	COG2027	D-alanyl-D-alanine carboxypeptidase
NicSoilB8_02580	COG0037	tRNA processing
NicSoilB8_02600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NicSoilB8_02610	COG0302	gtp cyclohydrolase
NicSoilB8_02620	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NicSoilB8_02690	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NicSoilB8_02700	COG2814	Major facilitator Superfamily
NicSoilB8_02720	COG1435	thymidine kinase activity
NicSoilB8_02750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NicSoilB8_02790	COG0823	Involved in the tonB-independent uptake of proteins
NicSoilB8_02790	COG1506	peptidase
NicSoilB8_02800	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NicSoilB8_02820	COG2376	Dihydroxyacetone kinase
NicSoilB8_02830	COG1461	Dihydroxyacetone kinase
NicSoilB8_02840	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
NicSoilB8_02880	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NicSoilB8_02890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NicSoilB8_02900	COG2815	serine threonine protein kinase
NicSoilB8_02900	COG0515	serine threonine protein kinase
NicSoilB8_02940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NicSoilB8_02950	COG2217	Heavy metal translocating P-type atpase
NicSoilB8_02960	COG2132	Multicopper oxidase
NicSoilB8_03000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NicSoilB8_03030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NicSoilB8_03040	COG0306	phosphate transporter
NicSoilB8_03090	COG0515	serine threonine protein kinase
NicSoilB8_03090	COG2815	serine threonine protein kinase
NicSoilB8_03210	COG2890	protein-(glutamine-N5) methyltransferase activity
NicSoilB8_03240	COG0667	Aldo Keto reductase
NicSoilB8_03250	COG3360	Dodecin
NicSoilB8_03270	COG1937	Protein conserved in bacteria
NicSoilB8_03280	COG2186	Transcriptional regulator
NicSoilB8_03300	COG2084	Dehydrogenase
NicSoilB8_03310	COG2610	gluconate transmembrane transporter activity
NicSoilB8_03390	COG0477	Major facilitator Superfamily
NicSoilB8_03410	COG1793	dna ligase
NicSoilB8_03410	COG3285	dna ligase
NicSoilB8_03420	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NicSoilB8_03450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NicSoilB8_03450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NicSoilB8_03450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NicSoilB8_03460	COG1105	Belongs to the carbohydrate kinase PfkB family
NicSoilB8_03470	COG1349	DNA-binding transcription factor activity
NicSoilB8_03500	COG1609	Transcriptional regulator
NicSoilB8_03550	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NicSoilB8_03570	COG1140	nitrate reductase beta subunit
NicSoilB8_03610	COG2733	membrane
NicSoilB8_03680	COG1064	alcohol dehydrogenase
NicSoilB8_03720	COG4122	O-methyltransferase activity
NicSoilB8_03770	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NicSoilB8_03780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NicSoilB8_03780	COG0574	Belongs to the PEP-utilizing enzyme family
NicSoilB8_03790	COG2217	Heavy metal translocating P-type atpase
NicSoilB8_03800	COG0726	polysaccharide deacetylase
NicSoilB8_03840	COG1295	ribonuclease BN
NicSoilB8_03890	COG0583	DNA-binding transcription factor activity
NicSoilB8_03910	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_03920	COG2826	transposase and inactivated derivatives, IS30 family
NicSoilB8_03930	COG1280	lysine exporter protein (LysE YggA)
NicSoilB8_03960	COG1476	TRANSCRIPTIONal
NicSoilB8_04000	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NicSoilB8_04030	COG1917	Cupin 2, conserved barrel domain protein
NicSoilB8_04030	COG1396	sequence-specific DNA binding
NicSoilB8_04050	COG0010	Belongs to the arginase family
NicSoilB8_04060	COG2252	PERMEase
NicSoilB8_04100	COG3848	Pyruvate phosphate dikinase
NicSoilB8_04100	COG0574	Belongs to the PEP-utilizing enzyme family
NicSoilB8_04180	COG0697	spore germination
NicSoilB8_04190	COG0583	DNA-binding transcription factor activity
NicSoilB8_04220	COG1796	DNA polymerase
NicSoilB8_04220	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NicSoilB8_04350	COG1609	Transcriptional regulator
NicSoilB8_04390	COG1024	Enoyl-CoA hydratase
NicSoilB8_04430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NicSoilB8_04430	COG2124	cytochrome p450
NicSoilB8_04440	COG1215	transferase activity, transferring glycosyl groups
NicSoilB8_04490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NicSoilB8_04500	COG1960	acyl-CoA dehydrogenase activity
NicSoilB8_04520	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilB8_04530	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NicSoilB8_04550	COG0531	amino acid
NicSoilB8_04560	COG2186	Transcriptional regulator
NicSoilB8_04620	COG1278	Cold shock
NicSoilB8_04640	COG0574	Belongs to the PEP-utilizing enzyme family
NicSoilB8_04640	COG3848	Pyruvate phosphate dikinase
NicSoilB8_04660	COG1063	alcohol dehydrogenase
NicSoilB8_04670	COG1250	3-hydroxyacyl-CoA dehydrogenase
NicSoilB8_04680	COG2197	response regulator
NicSoilB8_04710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NicSoilB8_04730	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NicSoilB8_04770	COG1609	Transcriptional regulator
NicSoilB8_04820	COG0444	Belongs to the ABC transporter superfamily
NicSoilB8_04850	COG0673	inositol 2-dehydrogenase activity
NicSoilB8_04860	COG1609	Transcriptional regulator
NicSoilB8_04870	COG1904	glucuronate isomerase
NicSoilB8_04880	COG0246	Mannitol dehydrogenase
NicSoilB8_04890	COG3250	beta-galactosidase activity
NicSoilB8_04910	COG4948	Mandelate Racemase Muconate Lactonizing
NicSoilB8_04970	COG1113	amino acid transport
NicSoilB8_04990	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilB8_05000	COG0022	dehydrogenase e1 component
NicSoilB8_05000	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilB8_05010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NicSoilB8_05020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NicSoilB8_05040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NicSoilB8_05090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NicSoilB8_05090	COG0357	Ribosomal RNA small subunit methyltransferase G
NicSoilB8_05110	COG0191	fructose-bisphosphate aldolase activity
NicSoilB8_05150	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NicSoilB8_05170	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NicSoilB8_05210	COG1832	CoA-binding protein
NicSoilB8_05240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NicSoilB8_05250	COG1832	CoA-binding protein
NicSoilB8_05260	COG2315	Protein conserved in bacteria
NicSoilB8_05270	COG4762	Protein conserved in bacteria
NicSoilB8_05310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NicSoilB8_05320	COG0047	phosphoribosylformylglycinamidine synthase activity
NicSoilB8_05390	COG1846	Transcriptional regulator
NicSoilB8_05440	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NicSoilB8_05490	COG0739	heme binding
NicSoilB8_05490	COG0741	lytic transglycosylase activity
NicSoilB8_05490	COG1196	nuclear chromosome segregation
NicSoilB8_05500	COG0386	Belongs to the glutathione peroxidase family
NicSoilB8_05510	COG1063	alcohol dehydrogenase
NicSoilB8_05520	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NicSoilB8_05530	COG0438	transferase activity, transferring glycosyl groups
NicSoilB8_05630	COG0823	Involved in the tonB-independent uptake of proteins
NicSoilB8_05660	COG0673	inositol 2-dehydrogenase activity
NicSoilB8_05670	COG0673	inositol 2-dehydrogenase activity
NicSoilB8_05690	COG0395	ABC-type sugar transport system, permease component
NicSoilB8_05730	COG0673	inositol 2-dehydrogenase activity
NicSoilB8_05740	COG1940	carbohydrate kinase activity
NicSoilB8_05760	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NicSoilB8_05800	COG0028	Belongs to the TPP enzyme family
NicSoilB8_05810	COG0351	phosphomethylpyrimidine kinase
NicSoilB8_05820	COG0477	Major facilitator Superfamily
NicSoilB8_05920	COG0673	inositol 2-dehydrogenase activity
NicSoilB8_05970	COG0343	queuine tRNA-ribosyltransferase activity
NicSoilB8_06030	COG0671	phosphoesterase, PA-phosphatase related
NicSoilB8_06050	COG3842	ATPase activity
NicSoilB8_06130	COG1309	transcriptional regulator
NicSoilB8_06140	COG0667	Aldo Keto reductase
NicSoilB8_06170	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NicSoilB8_06180	COG1120	ATPase activity
NicSoilB8_06190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NicSoilB8_06200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NicSoilB8_06230	COG0298	carbon dioxide binding
NicSoilB8_06280	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NicSoilB8_06330	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
NicSoilB8_06350	COG0586	Pfam SNARE associated Golgi protein
NicSoilB8_06360	COG0564	pseudouridine synthase activity
NicSoilB8_06400	COG2364	Membrane
NicSoilB8_06410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NicSoilB8_06420	COG1201	RNA secondary structure unwinding
NicSoilB8_06480	COG1609	Transcriptional regulator
NicSoilB8_06490	COG3250	beta-galactosidase activity
NicSoilB8_06500	COG0395	ABC-type sugar transport system, permease component
NicSoilB8_06530	COG2814	Major facilitator Superfamily
NicSoilB8_06550	COG1129	ABC transporter
NicSoilB8_06560	COG1172	Belongs to the binding-protein-dependent transport system permease family
NicSoilB8_06580	COG1879	ABC-type sugar transport system periplasmic component
NicSoilB8_06590	COG3254	rhamnose metabolic process
NicSoilB8_06600	COG4952	isomerase
NicSoilB8_06610	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_06610	COG3347	Dehydrogenase
NicSoilB8_06620	COG1070	Carbohydrate kinase
NicSoilB8_06630	COG0247	lactate metabolic process
NicSoilB8_06640	COG1139	Iron-sulfur cluster binding protein
NicSoilB8_06650	COG1556	Lactate utilization protein
NicSoilB8_06740	COG0438	transferase activity, transferring glycosyl groups
NicSoilB8_06770	COG0671	phosphoesterase, PA-phosphatase related
NicSoilB8_06780	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NicSoilB8_06810	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NicSoilB8_06820	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NicSoilB8_06820	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NicSoilB8_06850	COG2205	protein histidine kinase activity
NicSoilB8_06860	COG0745	RESPONSE REGULATOR receiver
NicSoilB8_06930	COG1309	transcriptional regulator
NicSoilB8_06940	COG1511	domain protein
NicSoilB8_06980	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
NicSoilB8_07000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NicSoilB8_07000	COG1017	nitric oxide dioxygenase activity
NicSoilB8_07010	COG1959	2 iron, 2 sulfur cluster binding
NicSoilB8_07030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NicSoilB8_07040	COG0514	ATP-dependent DNA helicase (RecQ)
NicSoilB8_07050	COG0477	Major facilitator Superfamily
NicSoilB8_07070	COG1505	serine-type exopeptidase activity
NicSoilB8_07130	COG0604	alcohol dehydrogenase
NicSoilB8_07150	COG1966	Carbon starvation protein
NicSoilB8_07190	COG0656	L-ascorbic acid biosynthetic process
NicSoilB8_07270	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NicSoilB8_07280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NicSoilB8_07320	COG0588	phosphoglycerate mutase activity
NicSoilB8_07340	COG5002	protein histidine kinase activity
NicSoilB8_07380	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NicSoilB8_07390	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NicSoilB8_07410	COG0215	cysteine-tRNA ligase activity
NicSoilB8_07420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NicSoilB8_07470	COG0366	Alpha amylase catalytic
NicSoilB8_07490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NicSoilB8_07530	COG1609	Transcriptional regulator
NicSoilB8_07540	COG0366	Alpha amylase catalytic
NicSoilB8_07570	COG3833	ABC-type maltose transport systems, permease component
NicSoilB8_07580	COG0366	Alpha amylase catalytic
NicSoilB8_07590	COG0277	FAD linked oxidase domain protein
NicSoilB8_07610	COG3842	ATPase activity
NicSoilB8_07640	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NicSoilB8_07680	COG2508	Transcriptional regulator
NicSoilB8_07700	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NicSoilB8_07710	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilB8_07810	COG2957	Belongs to the agmatine deiminase family
NicSoilB8_07820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NicSoilB8_07860	COG2124	cytochrome p450
NicSoilB8_07870	COG0783	Belongs to the Dps family
NicSoilB8_07880	COG0477	Major facilitator Superfamily
NicSoilB8_07900	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NicSoilB8_07900	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NicSoilB8_07910	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NicSoilB8_07920	COG0509	glycine decarboxylation via glycine cleavage system
NicSoilB8_07930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NicSoilB8_07950	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
NicSoilB8_07990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NicSoilB8_08020	COG1278	Cold shock
NicSoilB8_08040	COG0459	protein refolding
NicSoilB8_08050	COG0328	RNA-DNA hybrid ribonuclease activity
NicSoilB8_08070	COG2205	protein histidine kinase activity
NicSoilB8_08080	COG0745	RESPONSE REGULATOR receiver
NicSoilB8_08120	COG1278	Cold shock
NicSoilB8_08140	COG2814	Major facilitator Superfamily
NicSoilB8_08170	COG0739	heme binding
NicSoilB8_08230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NicSoilB8_08290	COG0488	(ABC) transporter
NicSoilB8_08300	COG1132	(ABC) transporter
NicSoilB8_08310	COG0494	nUDIX hydrolase
NicSoilB8_08400	COG0483	inositol monophosphate 1-phosphatase activity
NicSoilB8_08430	COG0045	succinate-CoA ligase (ADP-forming) activity
NicSoilB8_08460	COG0640	Transcriptional regulator
NicSoilB8_08470	COG1942	4-Oxalocrotonate Tautomerase
NicSoilB8_08480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NicSoilB8_08500	COG3962	Belongs to the TPP enzyme family
NicSoilB8_08530	COG0673	inositol 2-dehydrogenase activity
NicSoilB8_08540	COG1082	Xylose isomerase domain protein TIM barrel
NicSoilB8_08550	COG2814	Major facilitator Superfamily
NicSoilB8_08560	COG1846	Transcriptional regulator
NicSoilB8_08570	COG2814	Major facilitator Superfamily
NicSoilB8_08580	COG3718	enzyme involved in inositol metabolism
NicSoilB8_08590	COG2188	Transcriptional regulator
NicSoilB8_08610	COG1172	Belongs to the binding-protein-dependent transport system permease family
NicSoilB8_08630	COG0673	inositol 2-dehydrogenase activity
NicSoilB8_08640	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NicSoilB8_08660	COG2188	Transcriptional regulator
NicSoilB8_08680	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_08740	COG1396	sequence-specific DNA binding
NicSoilB8_08790	COG0028	Belongs to the TPP enzyme family
NicSoilB8_08860	COG1401	restriction endodeoxyribonuclease activity
NicSoilB8_08940	COG2072	flavoprotein involved in K transport
NicSoilB8_08950	COG1063	alcohol dehydrogenase
NicSoilB8_08960	COG1902	pentaerythritol trinitrate reductase activity
NicSoilB8_08990	COG2376	Dihydroxyacetone kinase
NicSoilB8_09000	COG0698	ribose 5-phosphate isomerase
NicSoilB8_09010	COG1250	3-hydroxyacyl-CoA dehydrogenase
NicSoilB8_09020	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_09030	COG2271	Major facilitator Superfamily
NicSoilB8_09040	COG0149	triose-phosphate isomerase activity
NicSoilB8_09070	COG2183	response to ionizing radiation
NicSoilB8_09090	COG0405	Gamma-glutamyltransferase
NicSoilB8_09110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NicSoilB8_09120	COG1695	Transcriptional regulator
NicSoilB8_09180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NicSoilB8_09210	COG1652	LysM domain
NicSoilB8_09230	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NicSoilB8_09240	COG0667	Aldo Keto reductase
NicSoilB8_09270	COG0366	Alpha amylase catalytic
NicSoilB8_09270	COG3103	Sh3 type 3 domain protein
NicSoilB8_09300	COG0366	Alpha amylase catalytic
NicSoilB8_09340	COG0180	Tryptophanyl-tRNA synthetase
NicSoilB8_09350	COG1254	Belongs to the acylphosphatase family
NicSoilB8_09390	COG0477	Major facilitator Superfamily
NicSoilB8_09410	COG0384	phenazine biosynthesis protein PhzF
NicSoilB8_09420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NicSoilB8_09500	COG1349	DNA-binding transcription factor activity
NicSoilB8_09510	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_09540	COG0667	Aldo Keto reductase
NicSoilB8_09550	COG4608	Belongs to the ABC transporter superfamily
NicSoilB8_09570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NicSoilB8_09580	COG0601	transmembrane transport
NicSoilB8_09600	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NicSoilB8_09610	COG2072	flavoprotein involved in K transport
NicSoilB8_09730	COG1595	DNA-templated transcription, initiation
NicSoilB8_09840	COG2801	Transposase and inactivated derivatives
NicSoilB8_09920	COG0071	Belongs to the small heat shock protein (HSP20) family
NicSoilB8_09960	COG3547	Transposase (IS116 IS110 IS902 family)
NicSoilB8_09980	COG0028	Belongs to the TPP enzyme family
NicSoilB8_10000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NicSoilB8_10010	COG1113	amino acid transport
NicSoilB8_10030	COG0366	Alpha amylase catalytic
NicSoilB8_10070	COG1609	Transcriptional regulator
NicSoilB8_10160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NicSoilB8_10380	COG2072	flavoprotein involved in K transport
NicSoilB8_10390	COG0456	acetyltransferase
NicSoilB8_10400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NicSoilB8_10410	COG0477	Major facilitator Superfamily
NicSoilB8_10430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NicSoilB8_10490	COG2186	Transcriptional regulator
NicSoilB8_10560	COG1278	Cold shock
NicSoilB8_10730	COG3665	Urea carboxylase-associated protein
NicSoilB8_10790	COG5001	Diguanylate cyclase
NicSoilB8_10800	COG5001	Diguanylate cyclase
NicSoilB8_10800	COG3300	MHYT domain
NicSoilB8_10810	COG0438	transferase activity, transferring glycosyl groups
NicSoilB8_10830	COG2268	Band 7 protein
NicSoilB8_10960	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilB8_10990	COG1024	Enoyl-CoA hydratase
NicSoilB8_11020	COG1396	sequence-specific DNA binding
NicSoilB8_11030	COG0477	Major facilitator Superfamily
NicSoilB8_11100	COG0477	Major facilitator Superfamily
NicSoilB8_11110	COG0138	bifunctional purine biosynthesis protein purh
NicSoilB8_11130	COG2838	Isocitrate dehydrogenase
NicSoilB8_11160	COG0515	serine threonine protein kinase
NicSoilB8_11160	COG2815	serine threonine protein kinase
NicSoilB8_11190	COG0673	inositol 2-dehydrogenase activity
NicSoilB8_11220	COG4213	ABC transporter substrate-binding protein
NicSoilB8_11230	COG1172	Belongs to the binding-protein-dependent transport system permease family
NicSoilB8_11280	COG0531	amino acid
NicSoilB8_11330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NicSoilB8_11340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NicSoilB8_11350	COG1131	(ABC) transporter
NicSoilB8_11410	COG0180	Tryptophanyl-tRNA synthetase
NicSoilB8_11450	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NicSoilB8_11480	COG2009	succinate dehydrogenase
NicSoilB8_11500	COG1473	amidohydrolase
NicSoilB8_11500	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NicSoilB8_11510	COG1846	Transcriptional regulator
NicSoilB8_11520	COG1764	response to oxidative stress
NicSoilB8_11530	COG2130	NADP-dependent
NicSoilB8_11540	COG1744	ABC transporter substrate-binding protein PnrA-like
NicSoilB8_11550	COG3845	ABC transporter
NicSoilB8_11560	COG4603	Belongs to the binding-protein-dependent transport system permease family
NicSoilB8_11570	COG1079	Belongs to the binding-protein-dependent transport system permease family
NicSoilB8_11610	COG0586	Pfam SNARE associated Golgi protein
NicSoilB8_11620	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NicSoilB8_11630	COG3956	TIGRFAM MazG family protein
NicSoilB8_11640	COG0148	phosphopyruvate hydratase activity
NicSoilB8_11690	COG1252	NADH dehydrogenase
NicSoilB8_11800	COG0183	Belongs to the thiolase family
NicSoilB8_11810	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NicSoilB8_11820	COG2017	converts alpha-aldose to the beta-anomer
NicSoilB8_11840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NicSoilB8_11860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NicSoilB8_11880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NicSoilB8_11900	COG1331	Highly conserved protein containing a thioredoxin domain
NicSoilB8_11910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NicSoilB8_11930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NicSoilB8_11940	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NicSoilB8_12040	COG0114	fumarate hydratase activity
NicSoilB8_12050	COG0288	reversible hydration of carbon dioxide
NicSoilB8_12070	COG1494	fructose-1,6-bisphosphatase
NicSoilB8_12100	COG1482	cell wall glycoprotein biosynthetic process
NicSoilB8_12110	COG1316	TRANSCRIPTIONal
NicSoilB8_12120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NicSoilB8_12220	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NicSoilB8_12230	COG1376	ErfK ybiS ycfS ynhG family protein
NicSoilB8_12310	COG0714	Associated with various cellular activities
NicSoilB8_12320	COG0084	hydrolase, TatD family'
NicSoilB8_12330	COG3583	domain protein
NicSoilB8_12340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NicSoilB8_12350	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NicSoilB8_12360	COG0488	(ABC) transporter
NicSoilB8_12380	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NicSoilB8_12400	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NicSoilB8_12410	COG0193	aminoacyl-tRNA hydrolase activity
NicSoilB8_12430	COG4566	intracellular signal transduction
NicSoilB8_12440	COG2197	response regulator
NicSoilB8_12490	COG0822	iron-sulfur transferase activity
NicSoilB8_12500	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NicSoilB8_12530	COG0702	epimerase
NicSoilB8_12560	COG1988	membrane-bound metal-dependent
NicSoilB8_12580	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NicSoilB8_12590	COG0446	pyridine nucleotide-disulphide oxidoreductase
NicSoilB8_12630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NicSoilB8_12650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NicSoilB8_12720	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
NicSoilB8_12780	COG0243	molybdopterin cofactor binding
NicSoilB8_12790	COG2223	nitrite transmembrane transporter activity
NicSoilB8_12800	COG0477	Major facilitator Superfamily
NicSoilB8_12830	COG4770	biotin carboxylase activity
NicSoilB8_12840	COG0424	maF-like protein
NicSoilB8_12850	COG2826	transposase and inactivated derivatives, IS30 family
NicSoilB8_12860	COG2409	Drug exporters of the RND superfamily
NicSoilB8_12890	COG1823	symporter activity
NicSoilB8_12920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NicSoilB8_12930	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_12940	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NicSoilB8_12940	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NicSoilB8_12980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NicSoilB8_12990	COG0483	inositol monophosphate 1-phosphatase activity
NicSoilB8_13010	COG0251	oxidation-reduction process
NicSoilB8_13030	COG4565	transcriptional regulatory protein
NicSoilB8_13050	COG2851	Citrate transporter
NicSoilB8_13060	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NicSoilB8_13070	COG0154	amidase activity
NicSoilB8_13080	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NicSoilB8_13100	COG1063	alcohol dehydrogenase
NicSoilB8_13110	COG0156	8-amino-7-oxononanoate synthase activity
NicSoilB8_13130	COG1228	amidohydrolase
NicSoilB8_13180	COG2873	o-acetylhomoserine
NicSoilB8_13190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NicSoilB8_13260	COG0400	carboxylic ester hydrolase activity
NicSoilB8_13290	COG0423	glycine-tRNA ligase activity
NicSoilB8_13380	COG0358	DNA primase activity
NicSoilB8_13400	COG2814	Major facilitator Superfamily
NicSoilB8_13420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NicSoilB8_13470	COG0052	Belongs to the universal ribosomal protein uS2 family
NicSoilB8_13480	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NicSoilB8_13490	COG0528	UMP kinase activity
NicSoilB8_13500	COG0233	cytoplasmic translational termination
NicSoilB8_13510	COG0575	Belongs to the CDS family
NicSoilB8_13530	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NicSoilB8_13560	COG3275	phosphorelay sensor kinase activity
NicSoilB8_13580	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NicSoilB8_13620	COG0022	dehydrogenase e1 component
NicSoilB8_13630	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilB8_13650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NicSoilB8_13670	COG1960	acyl-CoA dehydrogenase activity
NicSoilB8_13720	COG4565	transcriptional regulatory protein
NicSoilB8_13730	COG3290	protein histidine kinase activity
NicSoilB8_13780	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NicSoilB8_13790	COG0750	zinc metalloprotease
NicSoilB8_13980	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NicSoilB8_14010	COG0442	prolyl-tRNA aminoacylation
NicSoilB8_14040	COG3383	formate dehydrogenase (NAD+) activity
NicSoilB8_14060	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
NicSoilB8_14090	COG0779	Required for maturation of 30S ribosomal subunits
NicSoilB8_14120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NicSoilB8_14130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NicSoilB8_14140	COG3118	belongs to the thioredoxin family
NicSoilB8_14170	COG0436	Aminotransferase
NicSoilB8_14180	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NicSoilB8_14270	COG3483	tryptophan 2,3-dioxygenase activity
NicSoilB8_14290	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NicSoilB8_14300	COG1185	polyribonucleotide nucleotidyltransferase activity
NicSoilB8_14310	COG0612	Peptidase, M16
NicSoilB8_14370	COG0745	RESPONSE REGULATOR receiver
NicSoilB8_14380	COG5002	protein histidine kinase activity
NicSoilB8_14420	COG0521	Mo-molybdopterin cofactor biosynthetic process
NicSoilB8_14440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NicSoilB8_14490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NicSoilB8_14500	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NicSoilB8_14510	COG1674	ftsk spoiiie
NicSoilB8_14530	COG1546	Belongs to the CinA family
NicSoilB8_14530	COG1058	Belongs to the CinA family
NicSoilB8_14540	COG1396	sequence-specific DNA binding
NicSoilB8_14580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NicSoilB8_14590	COG2137	regulation of response to DNA damage stimulus
NicSoilB8_14610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NicSoilB8_14620	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NicSoilB8_14630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NicSoilB8_14640	COG2813	Specifically methylates the guanine in position
NicSoilB8_14650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NicSoilB8_14670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NicSoilB8_14690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NicSoilB8_14700	COG0131	Imidazoleglycerol-phosphate dehydratase
NicSoilB8_14710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NicSoilB8_14730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NicSoilB8_14770	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NicSoilB8_14780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NicSoilB8_14790	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NicSoilB8_14800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NicSoilB8_14810	COG2261	transglycosylase associated protein
NicSoilB8_14830	COG2814	Major facilitator Superfamily
NicSoilB8_14940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NicSoilB8_14950	COG0072	phenylalanine-tRNA ligase activity
NicSoilB8_14950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NicSoilB8_15010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NicSoilB8_15020	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NicSoilB8_15030	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NicSoilB8_15040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NicSoilB8_15050	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NicSoilB8_15060	COG1438	arginine binding
NicSoilB8_15070	COG0137	argininosuccinate synthase activity
NicSoilB8_15080	COG0165	Argininosuccinate lyase
NicSoilB8_15090	COG0259	pyridoxamine-phosphate oxidase activity
NicSoilB8_15110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NicSoilB8_15110	COG2169	Transcriptional regulator
NicSoilB8_15130	COG2094	Belongs to the DNA glycosylase MPG family
NicSoilB8_15160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NicSoilB8_15180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NicSoilB8_15250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NicSoilB8_15260	COG0497	DNA recombination
NicSoilB8_15270	COG0504	CTP synthase activity
NicSoilB8_15280	COG0494	nUDIX hydrolase
NicSoilB8_15320	COG1595	DNA-templated transcription, initiation
NicSoilB8_15360	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NicSoilB8_15370	COG2079	MmgE PrpD family protein
NicSoilB8_15410	COG3290	protein histidine kinase activity
NicSoilB8_15420	COG1301	dicarboxylic acid transport
NicSoilB8_15440	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NicSoilB8_15450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NicSoilB8_15480	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NicSoilB8_15500	COG1160	GTP binding
NicSoilB8_15520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NicSoilB8_15530	COG0509	glycine decarboxylation via glycine cleavage system
NicSoilB8_15580	COG1192	Involved in chromosome partitioning
NicSoilB8_15590	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NicSoilB8_15610	COG1940	carbohydrate kinase activity
NicSoilB8_15660	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NicSoilB8_15700	COG2815	serine threonine protein kinase
NicSoilB8_15700	COG0515	serine threonine protein kinase
NicSoilB8_15710	COG1388	LysM domain
NicSoilB8_15710	COG1705	Flagellar rod assembly protein muramidase FlgJ
NicSoilB8_15730	COG0142	geranyltranstransferase activity
NicSoilB8_15760	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NicSoilB8_15780	COG2001	Belongs to the MraZ family
NicSoilB8_15790	COG0275	rRNA processing
NicSoilB8_15810	COG0768	penicillin binding
NicSoilB8_15820	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NicSoilB8_15840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NicSoilB8_15850	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NicSoilB8_15860	COG0772	Belongs to the SEDS family
NicSoilB8_15870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NicSoilB8_15880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NicSoilB8_15900	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NicSoilB8_15910	COG1496	oxidoreductase activity
NicSoilB8_15930	COG1799	cell septum assembly
NicSoilB8_15950	COG3599	regulation of cell shape
NicSoilB8_15960	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NicSoilB8_15980	COG0587	DNA-directed DNA polymerase activity
NicSoilB8_16010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NicSoilB8_16020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NicSoilB8_16090	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NicSoilB8_16100	COG0174	glutamine synthetase
NicSoilB8_16110	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NicSoilB8_16190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NicSoilB8_16200	COG0321	lipoyl(octanoyl) transferase activity
NicSoilB8_16240	COG0793	Belongs to the peptidase S41A family
NicSoilB8_16240	COG4946	Tricorn protease homolog
NicSoilB8_16250	COG1764	response to oxidative stress
NicSoilB8_16280	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilB8_16290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NicSoilB8_16300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NicSoilB8_16360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NicSoilB8_16380	COG0187	DNA topoisomerase II activity
NicSoilB8_16420	COG1271	oxidase subunit
NicSoilB8_16430	COG1294	oxidase, subunit
NicSoilB8_16440	COG4988	ABC transporter
NicSoilB8_16490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NicSoilB8_16500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NicSoilB8_16500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NicSoilB8_16560	COG0756	dUTP diphosphatase activity
NicSoilB8_16610	COG0569	domain protein
NicSoilB8_16620	COG0531	amino acid
NicSoilB8_16630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NicSoilB8_16640	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NicSoilB8_16650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NicSoilB8_16680	COG0667	Aldo Keto reductase
NicSoilB8_16730	COG1122	ATPase activity
NicSoilB8_16750	COG1250	3-hydroxyacyl-CoA dehydrogenase
NicSoilB8_16750	COG1024	Enoyl-CoA hydratase
NicSoilB8_16760	COG0183	Belongs to the thiolase family
NicSoilB8_16770	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NicSoilB8_16830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NicSoilB8_16860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NicSoilB8_16920	COG0242	peptide deformylase activity
NicSoilB8_16930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NicSoilB8_16950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NicSoilB8_16980	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NicSoilB8_16980	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NicSoilB8_16990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NicSoilB8_16990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NicSoilB8_17000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NicSoilB8_17010	COG0140	phosphoribosyl-ATP diphosphatase activity
NicSoilB8_17020	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NicSoilB8_17030	COG0107	imidazoleglycerol-phosphate synthase activity
NicSoilB8_17050	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NicSoilB8_17090	COG0134	indole-3-glycerol-phosphate synthase activity
NicSoilB8_17100	COG0133	tryptophan synthase activity
NicSoilB8_17110	COG0159	tryptophan synthase activity
NicSoilB8_17120	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NicSoilB8_17130	COG0069	glutamate synthase activity
NicSoilB8_17130	COG0070	glutamate synthase
NicSoilB8_17130	COG0067	glutamate synthase
NicSoilB8_17150	COG0469	pyruvate kinase activity
NicSoilB8_17210	COG0210	DNA helicase
NicSoilB8_17320	COG5290	Psort location Cytoplasmic, score
NicSoilB8_17430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NicSoilB8_17520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilB8_17530	COG2814	Major facilitator Superfamily
NicSoilB8_17550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilB8_17630	COG1172	Belongs to the binding-protein-dependent transport system permease family
NicSoilB8_17640	COG1129	ABC transporter
NicSoilB8_17700	COG2801	Transposase and inactivated derivatives
NicSoilB8_17700	COG3415	Transposase
NicSoilB8_17720	COG3387	PFAM Glycoside hydrolase 15-related
NicSoilB8_17790	COG1414	Transcriptional regulator
NicSoilB8_17850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilB8_17880	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_17890	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_17900	COG2085	NADP oxidoreductase coenzyme F420-dependent
NicSoilB8_17910	COG0183	Belongs to the thiolase family
NicSoilB8_17920	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
NicSoilB8_17930	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_18040	COG2072	flavoprotein involved in K transport
NicSoilB8_18050	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_18080	COG0640	Transcriptional regulator
NicSoilB8_18110	COG3415	Transposase
NicSoilB8_18110	COG2801	Transposase and inactivated derivatives
NicSoilB8_18120	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
NicSoilB8_18140	COG0028	Belongs to the TPP enzyme family
NicSoilB8_18150	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilB8_18170	COG1802	Transcriptional regulator
NicSoilB8_18200	COG2814	Major facilitator Superfamily
NicSoilB8_18230	COG0477	Major facilitator Superfamily
NicSoilB8_18260	COG1621	beta-fructofuranosidase activity
NicSoilB8_18270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NicSoilB8_18280	COG1609	Transcriptional regulator
NicSoilB8_18300	COG0395	ABC-type sugar transport system, permease component
NicSoilB8_18380	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilB8_18400	COG0833	amino acid
NicSoilB8_18430	COG1414	Transcriptional regulator
NicSoilB8_18470	COG2040	homocysteine
NicSoilB8_18500	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
NicSoilB8_18510	COG1396	sequence-specific DNA binding
NicSoilB8_18530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NicSoilB8_18540	COG0531	amino acid
NicSoilB8_18600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NicSoilB8_18610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NicSoilB8_18630	COG0589	response to stress
NicSoilB8_18700	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NicSoilB8_18820	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NicSoilB8_18840	COG2267	carboxylic ester hydrolase activity
NicSoilB8_18920	COG2801	Transposase and inactivated derivatives
NicSoilB8_18950	COG3654	unkown
NicSoilB8_19010	COG0667	Aldo Keto reductase
NicSoilB8_19060	COG2159	amidohydrolase
NicSoilB8_19070	COG0583	DNA-binding transcription factor activity
NicSoilB8_19140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NicSoilB8_19160	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilB8_19170	COG0028	Belongs to the TPP enzyme family
NicSoilB8_19200	COG0477	Major facilitator Superfamily
NicSoilB8_19210	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NicSoilB8_19270	COG1473	amidohydrolase
NicSoilB8_19280	COG0477	Major facilitator Superfamily
NicSoilB8_19300	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NicSoilB8_19320	COG0667	Aldo Keto reductase
NicSoilB8_19360	COG0395	ABC-type sugar transport system, permease component
NicSoilB8_19400	COG1609	Transcriptional regulator
NicSoilB8_19410	COG1309	transcriptional regulator
NicSoilB8_19420	COG1902	pentaerythritol trinitrate reductase activity
NicSoilB8_19450	COG3321	synthase
NicSoilB8_19450	COG0604	alcohol dehydrogenase
NicSoilB8_19620	COG3485	protocatechuate 3,4-dioxygenase
NicSoilB8_19640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NicSoilB8_19660	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NicSoilB8_19700	COG0531	amino acid
NicSoilB8_19800	COG3328	transposase activity
NicSoilB8_19840	COG2160	L-arabinose isomerase activity
NicSoilB8_20170	COG0586	Pfam SNARE associated Golgi protein
NicSoilB8_20200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NicSoilB8_20260	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NicSoilB8_20270	COG1793	dna ligase
NicSoilB8_20270	COG3285	dna ligase
NicSoilB8_20300	COG0667	Aldo Keto reductase
NicSoilB8_20370	COG2814	Major facilitator Superfamily
NicSoilB8_20420	COG2814	Major facilitator Superfamily
NicSoilB8_20440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NicSoilB8_20620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NicSoilB8_20710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NicSoilB8_20720	COG1960	acyl-CoA dehydrogenase activity
NicSoilB8_20740	COG0702	epimerase
NicSoilB8_20780	COG0492	ferredoxin-NADP+ reductase activity
NicSoilB8_20790	COG2015	COG2015, Alkyl sulfatase and related hydrolases
NicSoilB8_20800	COG1280	lysine exporter protein (LysE YggA)
NicSoilB8_20810	COG0477	Major facilitator Superfamily
NicSoilB8_20830	COG0628	permease
NicSoilB8_20910	COG2909	trisaccharide binding
NicSoilB8_20910	COG2909	trisaccharide binding
NicSoilB8_20920	COG0589	response to stress
NicSoilB8_20940	COG1414	Transcriptional regulator
NicSoilB8_20960	COG0747	negative chemotaxis
NicSoilB8_21000	COG3250	beta-galactosidase activity
NicSoilB8_21020	COG3250	beta-galactosidase activity
NicSoilB8_21040	COG0657	acetylesterase activity
NicSoilB8_21050	COG0179	Fumarylacetoacetate (FAA) hydrolase
NicSoilB8_21060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NicSoilB8_21150	COG1643	Atp-dependent helicase
NicSoilB8_21160	COG1819	glycosyl
NicSoilB8_21240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NicSoilB8_21250	COG0730	response to heat
NicSoilB8_21270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NicSoilB8_21330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NicSoilB8_21330	COG0723	plastoquinol--plastocyanin reductase activity
NicSoilB8_21420	COG0745	RESPONSE REGULATOR receiver
NicSoilB8_21430	COG2205	protein histidine kinase activity
NicSoilB8_21460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NicSoilB8_21490	COG0009	L-threonylcarbamoyladenylate synthase
NicSoilB8_21540	COG2197	response regulator
NicSoilB8_21560	COG1222	aaa ATPase
NicSoilB8_21710	COG3629	intracellular signal transduction
NicSoilB8_21710	COG3903	Transcriptional regulator
NicSoilB8_21720	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_21730	COG2249	NAD(P)H dehydrogenase (quinone) activity
NicSoilB8_21750	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NicSoilB8_21750	COG3608	succinylglutamate desuccinylase aspartoacylase
NicSoilB8_21780	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NicSoilB8_21800	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NicSoilB8_21800	COG3608	succinylglutamate desuccinylase aspartoacylase
NicSoilB8_21890	COG2132	Multicopper oxidase
NicSoilB8_21910	COG0318	PFAM AMP-dependent synthetase and ligase
NicSoilB8_21920	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NicSoilB8_21940	COG0589	response to stress
NicSoilB8_21980	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NicSoilB8_21990	COG2050	protein possibly involved in aromatic compounds catabolism
NicSoilB8_22010	COG4552	Acetyltransferase involved in intracellular survival and related
NicSoilB8_22020	COG0539	negative regulation of cytoplasmic translation
NicSoilB8_22050	COG1739	Uncharacterized protein family UPF0029
NicSoilB8_22060	COG0237	dephospho-CoA kinase activity
NicSoilB8_22060	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NicSoilB8_22070	COG0556	nucleotide-excision repair
NicSoilB8_22130	COG4106	trans-aconitate 2-methyltransferase activity
NicSoilB8_22180	COG0546	phosphoglycolate phosphatase activity
NicSoilB8_22200	COG0322	excinuclease ABC activity
NicSoilB8_22210	COG1660	Displays ATPase and GTPase activities
NicSoilB8_22220	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NicSoilB8_22230	COG1481	regulation of sporulation
NicSoilB8_22240	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NicSoilB8_22260	COG0126	phosphoglycerate kinase activity
NicSoilB8_22270	COG0149	triose-phosphate isomerase activity
NicSoilB8_22280	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NicSoilB8_22300	COG0363	glucosamine-6-phosphate deaminase activity
NicSoilB8_22330	COG0166	Belongs to the GPI family
NicSoilB8_22340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NicSoilB8_22360	COG0109	protoheme IX farnesyltransferase activity
NicSoilB8_22370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NicSoilB8_22380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NicSoilB8_22380	COG2755	lipolytic protein G-D-S-L family
NicSoilB8_22400	COG1612	heme a metabolic process
NicSoilB8_22420	COG1131	(ABC) transporter
NicSoilB8_22470	COG0396	ATPase activity
NicSoilB8_22480	COG2151	metal-sulfur cluster biosynthetic enzyme
NicSoilB8_22510	COG0318	PFAM AMP-dependent synthetase and ligase
NicSoilB8_22540	COG1122	ATPase activity
NicSoilB8_22550	COG1268	BioY protein
NicSoilB8_22560	COG0488	(ABC) transporter
NicSoilB8_22610	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_22640	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_22650	COG3830	Belongs to the UPF0237 family
NicSoilB8_22650	COG0560	Phosphoserine phosphatase
NicSoilB8_22660	COG1119	ATPase activity
NicSoilB8_22690	COG0254	rRNA binding
NicSoilB8_22720	COG2855	membrane
NicSoilB8_22730	COG2308	Evidence 4 Homologs of previously reported genes of
NicSoilB8_22820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NicSoilB8_22830	COG0297	glycogen (starch) synthase activity
NicSoilB8_22870	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_22920	COG0435	Glutathione S-transferase
NicSoilB8_22980	COG3511	phospholipase C
NicSoilB8_23070	COG0667	Aldo Keto reductase
NicSoilB8_23080	COG1968	undecaprenyl-diphosphatase activity
NicSoilB8_23090	COG0215	cysteine-tRNA ligase activity
NicSoilB8_23110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NicSoilB8_23140	COG1222	aaa ATPase
NicSoilB8_23150	COG4122	O-methyltransferase activity
NicSoilB8_23170	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NicSoilB8_23180	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NicSoilB8_23190	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NicSoilB8_23240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NicSoilB8_23250	COG0805	protein transport
NicSoilB8_23260	COG4581	dead DEAH box helicase
NicSoilB8_23270	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NicSoilB8_23280	COG1216	Glycosyl transferase, family 2
NicSoilB8_23330	COG0823	Involved in the tonB-independent uptake of proteins
NicSoilB8_23330	COG4946	Tricorn protease homolog
NicSoilB8_23330	COG1506	peptidase
NicSoilB8_23340	COG0242	peptide deformylase activity
NicSoilB8_23370	COG2264	protein methyltransferase activity
NicSoilB8_23380	COG3424	synthase
NicSoilB8_23460	COG0179	Fumarylacetoacetate (FAA) hydrolase
NicSoilB8_23490	COG2814	Major facilitator Superfamily
NicSoilB8_23500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NicSoilB8_23510	COG1609	Transcriptional regulator
NicSoilB8_23530	COG1175	transmembrane transport
NicSoilB8_23540	COG0395	ABC-type sugar transport system, permease component
NicSoilB8_23550	COG1621	beta-fructofuranosidase activity
NicSoilB8_23620	COG2261	transglycosylase associated protein
NicSoilB8_23670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilB8_23700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NicSoilB8_23740	COG0492	ferredoxin-NADP+ reductase activity
NicSoilB8_23750	COG3800	Transcriptional regulator
NicSoilB8_23750	COG1396	sequence-specific DNA binding
NicSoilB8_23780	COG0076	glutamate decarboxylase activity
NicSoilB8_23850	COG0789	Transcriptional regulator
NicSoilB8_23860	COG3177	Filamentation induced by cAMP protein fic
NicSoilB8_23880	COG0477	Major facilitator Superfamily
NicSoilB8_23940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NicSoilB8_23950	COG1845	cytochrome c oxidase, subunit III
NicSoilB8_23960	COG2010	Cytochrome c
NicSoilB8_23970	COG0723	plastoquinol--plastocyanin reductase activity
NicSoilB8_23980	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NicSoilB8_23990	COG2188	Transcriptional regulator
NicSoilB8_24000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NicSoilB8_24020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NicSoilB8_24030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NicSoilB8_24070	COG0167	dihydroorotate dehydrogenase activity
NicSoilB8_24100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NicSoilB8_24110	COG1381	Involved in DNA repair and RecF pathway recombination
NicSoilB8_24120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NicSoilB8_24130	COG3590	peptidase
NicSoilB8_24160	COG1316	TRANSCRIPTIONal
NicSoilB8_24170	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NicSoilB8_24190	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NicSoilB8_24280	COG0798	PFAM Bile acid sodium symporter
NicSoilB8_24290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NicSoilB8_24310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NicSoilB8_24370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NicSoilB8_24380	COG0484	heat shock protein binding
NicSoilB8_24390	COG1420	regulation of RNA biosynthetic process
NicSoilB8_24440	COG0481	GTPase activity
NicSoilB8_24460	COG0268	Binds directly to 16S ribosomal RNA
NicSoilB8_24500	COG1555	photosystem II stabilization
NicSoilB8_24500	COG1596	polysaccharide export
NicSoilB8_24540	COG1307	EDD domain protein, DegV family
NicSoilB8_24550	COG0495	leucyl-tRNA aminoacylation
NicSoilB8_24610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NicSoilB8_24620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NicSoilB8_24630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NicSoilB8_24650	COG0656	L-ascorbic acid biosynthetic process
NicSoilB8_24690	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NicSoilB8_24710	COG1758	RNA polymerase activity
NicSoilB8_24720	COG0194	GDP metabolic process
NicSoilB8_24730	COG0194	GDP metabolic process
NicSoilB8_24740	COG0284	orotidine-5'-phosphate decarboxylase activity
NicSoilB8_24750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NicSoilB8_24760	COG0505	Belongs to the CarA family
NicSoilB8_24780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NicSoilB8_24790	COG0540	Belongs to the ATCase OTCase family
NicSoilB8_24800	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NicSoilB8_24820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NicSoilB8_24830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NicSoilB8_24850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NicSoilB8_24860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NicSoilB8_24870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NicSoilB8_24880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NicSoilB8_24900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NicSoilB8_24910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NicSoilB8_24940	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NicSoilB8_25030	COG1414	Transcriptional regulator
NicSoilB8_25040	COG1053	succinate dehydrogenase
NicSoilB8_25050	COG1414	Transcriptional regulator
NicSoilB8_25070	COG1053	succinate dehydrogenase
NicSoilB8_25090	COG0477	Major facilitator Superfamily
NicSoilB8_25120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NicSoilB8_25140	COG0124	histidyl-tRNA synthetase
NicSoilB8_25160	COG1196	nuclear chromosome segregation
NicSoilB8_25180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NicSoilB8_25190	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NicSoilB8_25200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NicSoilB8_25220	COG2255	four-way junction helicase activity
NicSoilB8_25230	COG0632	four-way junction helicase activity
NicSoilB8_25240	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NicSoilB8_25250	COG0217	transcriptional regulatory protein
NicSoilB8_25260	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NicSoilB8_25270	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NicSoilB8_25330	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NicSoilB8_25340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NicSoilB8_25360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NicSoilB8_25370	COG0587	DNA-directed DNA polymerase activity
NicSoilB8_25400	COG1605	Chorismate mutase
NicSoilB8_25400	COG0077	Prephenate dehydratase
NicSoilB8_25450	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NicSoilB8_25460	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NicSoilB8_25470	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NicSoilB8_25510	COG2135	peptidase activity
NicSoilB8_25580	COG2801	Transposase and inactivated derivatives
NicSoilB8_25630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NicSoilB8_25740	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NicSoilB8_25750	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NicSoilB8_25770	COG0577	efflux transmembrane transporter activity
NicSoilB8_25770	COG1136	(ABC) transporter
NicSoilB8_25810	COG2822	iron ion transport
NicSoilB8_25820	COG2837	iron assimilation
NicSoilB8_25870	COG2186	Transcriptional regulator
NicSoilB8_25890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NicSoilB8_26120	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NicSoilB8_26140	COG0671	phosphoesterase, PA-phosphatase related
NicSoilB8_26150	COG0586	Pfam SNARE associated Golgi protein
NicSoilB8_26170	COG5002	protein histidine kinase activity
NicSoilB8_26210	COG0475	glutathione-regulated potassium exporter activity
NicSoilB8_26210	COG0569	domain protein
NicSoilB8_26380	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NicSoilB8_26400	COG1053	succinate dehydrogenase
NicSoilB8_26410	COG0656	L-ascorbic acid biosynthetic process
NicSoilB8_26430	COG0446	pyridine nucleotide-disulphide oxidoreductase
NicSoilB8_26430	COG1902	pentaerythritol trinitrate reductase activity
NicSoilB8_26440	COG0673	inositol 2-dehydrogenase activity
NicSoilB8_26450	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_26460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NicSoilB8_26480	COG0583	DNA-binding transcription factor activity
NicSoilB8_26510	COG0596	Alpha beta hydrolase
NicSoilB8_26540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NicSoilB8_26560	COG0765	amino acid transport
NicSoilB8_26570	COG1126	abc transporter atp-binding protein
NicSoilB8_26580	COG2423	ornithine cyclodeaminase activity
NicSoilB8_26630	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilB8_26640	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NicSoilB8_26650	COG0277	FAD linked oxidase domain protein
NicSoilB8_26650	COG0247	lactate metabolic process
NicSoilB8_26670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NicSoilB8_26700	COG1942	4-Oxalocrotonate Tautomerase
NicSoilB8_26710	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_26740	COG2070	2-Nitropropane dioxygenase
NicSoilB8_26750	COG2814	Major facilitator Superfamily
NicSoilB8_26850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilB8_26860	COG3511	phospholipase C
NicSoilB8_26890	COG1335	isochorismatase
NicSoilB8_26900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NicSoilB8_26910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NicSoilB8_26920	COG1780	Probably involved in ribonucleotide reductase function
NicSoilB8_26940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NicSoilB8_26950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NicSoilB8_26980	COG0583	DNA-binding transcription factor activity
NicSoilB8_27000	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilB8_27060	COG2890	protein-(glutamine-N5) methyltransferase activity
NicSoilB8_27080	COG2824	Alkylphosphonate utilization operon protein PhnA
NicSoilB8_27090	COG1126	abc transporter atp-binding protein
NicSoilB8_27100	COG0765	amino acid transport
NicSoilB8_27110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NicSoilB8_27120	COG0799	negative regulation of ribosome biogenesis
NicSoilB8_27140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NicSoilB8_27160	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NicSoilB8_27170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NicSoilB8_27180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NicSoilB8_27200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NicSoilB8_27210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NicSoilB8_27220	COG0352	thiamine-phosphate diphosphorylase activity
NicSoilB8_27220	COG0351	phosphomethylpyrimidine kinase
NicSoilB8_27220	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NicSoilB8_27230	COG1530	ribonuclease E activity
NicSoilB8_27270	COG0285	dihydrofolate synthase activity
NicSoilB8_27280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NicSoilB8_27340	COG3189	MarR family transcriptional regulator
NicSoilB8_27350	COG0525	valine-tRNA ligase activity
NicSoilB8_27370	COG3387	PFAM Glycoside hydrolase 15-related
NicSoilB8_27380	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NicSoilB8_27390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NicSoilB8_27400	COG0740	serine-type endopeptidase activity
NicSoilB8_27410	COG0740	serine-type endopeptidase activity
NicSoilB8_27420	COG0544	peptidyl-prolyl cis-trans isomerase activity
NicSoilB8_27480	COG0668	transmembrane transport
NicSoilB8_27520	COG1946	Acyl-CoA thioesterase
NicSoilB8_27550	COG0629	single-stranded DNA binding
NicSoilB8_27570	COG0598	Magnesium transport protein CorA
NicSoilB8_27580	COG5416	Lipopolysaccharide assembly protein A domain
NicSoilB8_27680	COG2326	polyphosphate kinase activity
NicSoilB8_27750	COG0330	HflC and HflK could
NicSoilB8_27770	COG3022	response to hydroperoxide
NicSoilB8_27790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NicSoilB8_27800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NicSoilB8_27820	COG1045	serine acetyltransferase
NicSoilB8_27830	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_27840	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NicSoilB8_27860	COG1063	alcohol dehydrogenase
NicSoilB8_27870	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_27890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NicSoilB8_27900	COG0477	Major facilitator Superfamily
NicSoilB8_27990	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NicSoilB8_28020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NicSoilB8_28030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NicSoilB8_28040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NicSoilB8_28060	COG4974	Belongs to the 'phage' integrase family
NicSoilB8_28090	COG0792	nuclease activity
NicSoilB8_28100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NicSoilB8_28120	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NicSoilB8_28140	COG0681	Belongs to the peptidase S26 family
NicSoilB8_28150	COG0335	large ribosomal subunit rRNA binding
NicSoilB8_28160	COG0336	Belongs to the RNA methyltransferase TrmD family
NicSoilB8_28170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NicSoilB8_28180	COG1837	Belongs to the UPF0109 family
NicSoilB8_28190	COG0228	four-way junction DNA binding
NicSoilB8_28210	COG2514	catechol 2,3-dioxygenase activity
NicSoilB8_28230	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NicSoilB8_28260	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NicSoilB8_28290	COG2814	Major facilitator Superfamily
NicSoilB8_28340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NicSoilB8_28350	COG0318	PFAM AMP-dependent synthetase and ligase
NicSoilB8_28360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NicSoilB8_28390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NicSoilB8_28400	COG0571	ribonuclease III activity
NicSoilB8_28410	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NicSoilB8_28430	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NicSoilB8_28440	COG0300	oxidoreductase activity
NicSoilB8_28470	COG0742	ribosomal rna small subunit methyltransferase
NicSoilB8_28540	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NicSoilB8_28570	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NicSoilB8_28650	COG1215	transferase activity, transferring glycosyl groups
NicSoilB8_28680	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NicSoilB8_28700	COG1134	teichoic acid transport
NicSoilB8_28720	COG0297	glycogen (starch) synthase activity
NicSoilB8_28770	COG1181	Belongs to the D-alanine--D-alanine ligase family
NicSoilB8_28780	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NicSoilB8_28800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NicSoilB8_28810	COG0066	3-isopropylmalate dehydratase activity
NicSoilB8_28820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NicSoilB8_28830	COG1414	Transcriptional regulator
NicSoilB8_28880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NicSoilB8_28890	COG0179	Fumarylacetoacetate (FAA) hydrolase
NicSoilB8_28920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NicSoilB8_28930	COG0473	3-isopropylmalate dehydrogenase activity
NicSoilB8_28950	COG0577	efflux transmembrane transporter activity
NicSoilB8_28950	COG1136	(ABC) transporter
NicSoilB8_28970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NicSoilB8_28980	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NicSoilB8_28990	COG0440	acetolactate synthase activity
NicSoilB8_29020	COG0129	dihydroxy-acid dehydratase activity
NicSoilB8_29040	COG0088	Forms part of the polypeptide exit tunnel
NicSoilB8_29250	COG1793	dna ligase
NicSoilB8_29260	COG1793	dna ligase
NicSoilB8_29360	COG0747	negative chemotaxis
NicSoilB8_29370	COG0579	oxidoreductase
NicSoilB8_29380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NicSoilB8_29470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilB8_29490	COG1305	Transglutaminase-like
NicSoilB8_29510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NicSoilB8_29540	COG1104	cysteine desulfurase activity
NicSoilB8_29560	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NicSoilB8_29570	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NicSoilB8_29620	COG1113	amino acid transport
NicSoilB8_29640	COG0022	dehydrogenase e1 component
NicSoilB8_29650	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilB8_29670	COG0477	Major facilitator Superfamily
NicSoilB8_29720	COG0419	ATPase involved in DNA repair
NicSoilB8_29740	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NicSoilB8_29760	COG2149	membrane
NicSoilB8_29800	COG0586	Pfam SNARE associated Golgi protein
NicSoilB8_29810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NicSoilB8_29820	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NicSoilB8_29830	COG1234	tRNA 3'-trailer cleavage
NicSoilB8_29840	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NicSoilB8_29860	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NicSoilB8_29880	COG1335	isochorismatase
NicSoilB8_29920	COG0363	glucosamine-6-phosphate deaminase activity
NicSoilB8_29950	COG1902	pentaerythritol trinitrate reductase activity
NicSoilB8_30010	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
NicSoilB8_30030	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NicSoilB8_30040	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NicSoilB8_30060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NicSoilB8_30070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NicSoilB8_30080	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NicSoilB8_30090	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NicSoilB8_30100	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NicSoilB8_30110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NicSoilB8_30120	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NicSoilB8_30130	COG0356	it plays a direct role in the translocation of protons across the membrane
NicSoilB8_30200	COG2890	protein-(glutamine-N5) methyltransferase activity
NicSoilB8_30210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NicSoilB8_30230	COG0083	homoserine kinase activity
NicSoilB8_30240	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NicSoilB8_30250	COG0460	homoserine dehydrogenase
NicSoilB8_30260	COG0019	diaminopimelate decarboxylase activity
NicSoilB8_30270	COG0018	arginyl-trna synthetase
NicSoilB8_30350	COG4829	muconolactone delta-isomerase
NicSoilB8_30360	COG3485	protocatechuate 3,4-dioxygenase
NicSoilB8_30380	COG0583	DNA-binding transcription factor activity
NicSoilB8_30390	COG4638	Rieske (2fe-2S)
NicSoilB8_30400	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
NicSoilB8_30430	COG2814	Major facilitator Superfamily
NicSoilB8_30450	COG1643	Atp-dependent helicase
NicSoilB8_30460	COG0537	adenosine 5'-monophosphoramidase activity
NicSoilB8_30470	COG1064	alcohol dehydrogenase
NicSoilB8_30530	COG1121	(ABC) transporter
NicSoilB8_30580	COG0567	Dehydrogenase, E1 component
NicSoilB8_30580	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilB8_30630	COG1595	DNA-templated transcription, initiation
NicSoilB8_30650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NicSoilB8_30670	COG0483	inositol monophosphate 1-phosphatase activity
NicSoilB8_30680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NicSoilB8_30720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NicSoilB8_30730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NicSoilB8_30790	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NicSoilB8_30820	COG2884	Cell division ATP-binding protein ftsE
NicSoilB8_30830	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NicSoilB8_30920	COG2246	polysaccharide biosynthetic process
NicSoilB8_30960	COG1088	dTDP-glucose 4,6-dehydratase activity
NicSoilB8_31010	COG0463	Glycosyl transferase, family 2
NicSoilB8_31070	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NicSoilB8_31140	COG1216	Glycosyl transferase, family 2
NicSoilB8_31170	COG1674	ftsk spoiiie
NicSoilB8_31210	COG2902	Dehydrogenase
NicSoilB8_31280	COG0653	protein targeting
NicSoilB8_31290	COG3214	Protein conserved in bacteria
NicSoilB8_31300	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NicSoilB8_31310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NicSoilB8_31320	COG5401	PFAM Sporulation and spore germination
NicSoilB8_31330	COG5000	phosphorelay sensor kinase activity
NicSoilB8_31330	COG5002	protein histidine kinase activity
NicSoilB8_31400	COG0601	transmembrane transport
NicSoilB8_31420	COG0482	sulfurtransferase activity
NicSoilB8_31480	COG1597	lipid kinase activity
NicSoilB8_31500	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NicSoilB8_31510	COG1595	DNA-templated transcription, initiation
NicSoilB8_31540	COG3265	gluconokinase activity
NicSoilB8_31550	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NicSoilB8_31560	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NicSoilB8_31570	COG2086	electron transfer activity
NicSoilB8_31580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NicSoilB8_31600	COG1842	Phage shock protein A
NicSoilB8_31610	COG0415	Belongs to the DNA photolyase family
NicSoilB8_31620	COG1615	UPF0182 protein
NicSoilB8_31630	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NicSoilB8_31670	COG2816	NAD+ diphosphatase activity
NicSoilB8_31730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NicSoilB8_31740	COG0765	amino acid transport
NicSoilB8_31750	COG1126	abc transporter atp-binding protein
NicSoilB8_31760	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NicSoilB8_31770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilB8_31780	COG0113	porphobilinogen synthase activity
NicSoilB8_31800	COG0181	hydroxymethylbilane synthase activity
NicSoilB8_31810	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NicSoilB8_31820	COG3253	May function as heme-dependent peroxidase
NicSoilB8_31850	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NicSoilB8_31860	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NicSoilB8_31920	COG2022	thiamine diphosphate biosynthetic process
NicSoilB8_31940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NicSoilB8_31940	COG2022	thiamine diphosphate biosynthetic process
NicSoilB8_31950	COG0352	thiamine-phosphate diphosphorylase activity
NicSoilB8_31980	COG0513	Belongs to the DEAD box helicase family
NicSoilB8_31990	COG2189	Belongs to the N(4) N(6)-methyltransferase family
NicSoilB8_32000	COG0613	PHP domain protein
NicSoilB8_32010	COG0006	proline dipeptidase activity
NicSoilB8_32030	COG2239	Acts as a magnesium transporter
NicSoilB8_32060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NicSoilB8_32080	COG1595	DNA-templated transcription, initiation
NicSoilB8_32140	COG1126	abc transporter atp-binding protein
NicSoilB8_32150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NicSoilB8_32160	COG0765	amino acid transport
NicSoilB8_32170	COG0765	amino acid transport
NicSoilB8_32180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NicSoilB8_32190	COG2171	N-acyltransferase activity
NicSoilB8_32220	COG3226	Transcriptional regulator
NicSoilB8_32290	COG1217	gtp-binding protein TYPA
NicSoilB8_32320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NicSoilB8_32330	COG0601	transmembrane transport
NicSoilB8_32340	COG4166	transmembrane transport
NicSoilB8_32350	COG4172	Belongs to the ABC transporter superfamily
NicSoilB8_32370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NicSoilB8_32390	COG4166	transmembrane transport
NicSoilB8_32400	COG0012	GTP binding
NicSoilB8_32410	COG1322	Protein conserved in bacteria
NicSoilB8_32420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NicSoilB8_32450	COG1570	exodeoxyribonuclease VII activity
NicSoilB8_32460	COG1722	exodeoxyribonuclease VII activity
NicSoilB8_32470	COG2326	polyphosphate kinase activity
NicSoilB8_32480	COG0436	Aminotransferase
NicSoilB8_32500	COG1174	glycine betaine transport
NicSoilB8_32520	COG1162	GTPase activity
NicSoilB8_32550	COG2971	BadF BadG BcrA BcrD
NicSoilB8_32560	COG0583	DNA-binding transcription factor activity
NicSoilB8_32570	COG2814	Major facilitator Superfamily
NicSoilB8_32580	COG0626	cystathionine gamma-synthase activity
NicSoilB8_32620	COG0598	Magnesium transport protein CorA
NicSoilB8_32650	COG0488	(ABC) transporter
NicSoilB8_32710	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NicSoilB8_32720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NicSoilB8_32760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NicSoilB8_32760	COG0519	Catalyzes the synthesis of GMP from XMP
NicSoilB8_32800	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NicSoilB8_32810	COG0516	GMP reductase activity
NicSoilB8_32830	COG1132	(ABC) transporter
NicSoilB8_32880	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NicSoilB8_32880	COG2755	lipolytic protein G-D-S-L family
NicSoilB8_32890	COG0459	protein refolding
NicSoilB8_32900	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NicSoilB8_32930	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NicSoilB8_32940	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NicSoilB8_32950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NicSoilB8_32980	COG0802	atpase or kinase
NicSoilB8_32990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NicSoilB8_33010	COG1486	melibiose metabolic process
NicSoilB8_33030	COG0438	transferase activity, transferring glycosyl groups
NicSoilB8_33040	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NicSoilB8_33060	COG0667	Aldo Keto reductase
NicSoilB8_33110	COG0736	holo-[acyl-carrier-protein] synthase activity
NicSoilB8_33120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NicSoilB8_33140	COG1072	(Pantothenic acid kinase))
NicSoilB8_33160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NicSoilB8_33180	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NicSoilB8_33190	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NicSoilB8_33200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NicSoilB8_33260	COG2894	cell division
NicSoilB8_33340	COG2894	cell division
NicSoilB8_33420	COG5002	protein histidine kinase activity
NicSoilB8_33430	COG0101	tRNA pseudouridine synthase activity
NicSoilB8_33440	COG0203	ribosomal protein L17
NicSoilB8_33450	COG0202	RNA polymerase activity
NicSoilB8_33460	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NicSoilB8_33470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NicSoilB8_33480	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NicSoilB8_33490	COG3191	aminopeptidase activity
NicSoilB8_33500	COG1175	transmembrane transport
NicSoilB8_33540	COG0563	adenylate kinase activity
NicSoilB8_33560	COG0200	Binds to the 23S rRNA
NicSoilB8_33570	COG1841	ribosomal large subunit assembly
NicSoilB8_33580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NicSoilB8_33600	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NicSoilB8_33610	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NicSoilB8_33620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NicSoilB8_33630	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NicSoilB8_33640	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NicSoilB8_33650	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NicSoilB8_33660	COG0255	Belongs to the universal ribosomal protein uL29 family
NicSoilB8_33670	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NicSoilB8_33680	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NicSoilB8_33690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NicSoilB8_33700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NicSoilB8_33710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NicSoilB8_33720	COG0089	rRNA binding
NicSoilB8_33730	COG0088	Forms part of the polypeptide exit tunnel
NicSoilB8_33740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NicSoilB8_33750	COG0051	transcription antitermination factor activity, RNA binding
NicSoilB8_33790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NicSoilB8_33800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NicSoilB8_33810	COG0049	tRNA binding
NicSoilB8_33820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NicSoilB8_33830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NicSoilB8_33840	COG0085	RNA polymerase activity
NicSoilB8_33850	COG0183	Belongs to the thiolase family
NicSoilB8_33860	COG0442	prolyl-tRNA aminoacylation
NicSoilB8_33870	COG0737	Belongs to the 5'-nucleotidase family
NicSoilB8_33880	COG0222	ribosome binding
NicSoilB8_33890	COG0222	ribosome binding
NicSoilB8_33900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NicSoilB8_33950	COG2814	Major facilitator Superfamily
NicSoilB8_33960	COG2814	Major facilitator Superfamily
NicSoilB8_33970	COG0081	regulation of translation
NicSoilB8_33980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NicSoilB8_34000	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NicSoilB8_34010	COG0436	Aminotransferase
NicSoilB8_34020	COG2197	response regulator
NicSoilB8_34120	COG0354	folic acid binding
NicSoilB8_34140	COG3485	protocatechuate 3,4-dioxygenase
NicSoilB8_34160	COG0745	RESPONSE REGULATOR receiver
NicSoilB8_34170	COG0456	acetyltransferase
NicSoilB8_34180	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NicSoilB8_34220	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NicSoilB8_34250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NicSoilB8_34280	COG1473	amidohydrolase
NicSoilB8_34350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NicSoilB8_34360	COG0738	Major facilitator superfamily
NicSoilB8_34380	COG2030	dehydratase
NicSoilB8_34400	COG0659	secondary active sulfate transmembrane transporter activity
NicSoilB8_34440	COG4989	oxidoreductase activity
NicSoilB8_34450	COG0366	Alpha amylase catalytic
NicSoilB8_34460	COG1940	carbohydrate kinase activity
NicSoilB8_34480	COG0702	epimerase
NicSoilB8_34490	COG0706	membrane insertase activity
NicSoilB8_34530	COG4974	Belongs to the 'phage' integrase family
NicSoilB8_34860	COG2304	oxidoreductase activity
NicSoilB8_34940	COG1960	acyl-CoA dehydrogenase activity
NicSoilB8_34970	COG5650	phosphatidylinositol metabolic process
NicSoilB8_35020	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NicSoilB8_35060	COG0318	PFAM AMP-dependent synthetase and ligase
NicSoilB8_35080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NicSoilB8_35100	COG3340	Belongs to the peptidase S51 family
NicSoilB8_35120	COG0346	lactoylglutathione lyase activity
NicSoilB8_35140	COG1285	pathogenesis
NicSoilB8_35150	COG3559	Exporter of polyketide antibiotics
NicSoilB8_35160	COG1131	(ABC) transporter
NicSoilB8_35200	COG2318	DinB family
NicSoilB8_35230	COG1666	GTP binding
NicSoilB8_35240	COG0501	Belongs to the peptidase M48B family
NicSoilB8_35300	COG0531	amino acid
NicSoilB8_35360	COG0154	amidase activity
NicSoilB8_35450	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilB8_35460	COG3835	regulator
NicSoilB8_35480	COG2186	Transcriptional regulator
NicSoilB8_35500	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NicSoilB8_35560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NicSoilB8_35560	COG1648	precorrin-2 dehydrogenase activity
NicSoilB8_35580	COG2826	transposase and inactivated derivatives, IS30 family
NicSoilB8_35600	COG1116	anion transmembrane transporter activity
NicSoilB8_35650	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NicSoilB8_35670	COG2860	membrane
NicSoilB8_35700	COG0142	geranyltranstransferase activity
NicSoilB8_35710	COG0644	oxidoreductase
NicSoilB8_35720	COG2226	methyltransferase
NicSoilB8_35730	COG1169	isochorismate synthase
NicSoilB8_35750	COG0765	amino acid transport
NicSoilB8_35760	COG1126	abc transporter atp-binding protein
NicSoilB8_35780	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NicSoilB8_35790	COG0018	arginyl-trna synthetase
NicSoilB8_35810	COG1846	Transcriptional regulator
NicSoilB8_35820	COG4948	Mandelate Racemase Muconate Lactonizing
NicSoilB8_35840	COG3764	Sortase (surface protein transpeptidase)
NicSoilB8_35960	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilB8_35970	COG0022	dehydrogenase e1 component
NicSoilB8_36000	COG0489	protein tyrosine kinase activity
NicSoilB8_36060	COG1484	DNA-dependent DNA replication
NicSoilB8_36170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NicSoilB8_36180	COG1024	Enoyl-CoA hydratase
NicSoilB8_36190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NicSoilB8_36200	COG2151	metal-sulfur cluster biosynthetic enzyme
NicSoilB8_36210	COG3396	Phenylacetate-CoA oxygenase
NicSoilB8_36220	COG3460	Phenylacetate-CoA oxygenase
NicSoilB8_36230	COG3396	Phenylacetate-CoA oxygenase
NicSoilB8_36260	COG0681	Belongs to the peptidase S26 family
NicSoilB8_36270	COG0489	protein tyrosine kinase activity
NicSoilB8_36300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NicSoilB8_36400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NicSoilB8_36410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NicSoilB8_36420	COG0857	belongs to the CobB CobQ family
NicSoilB8_36420	COG0280	phosphate acetyltransferase
NicSoilB8_36430	COG2050	protein possibly involved in aromatic compounds catabolism
NicSoilB8_36490	COG2030	dehydratase
NicSoilB8_36490	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilB8_36500	COG2050	protein possibly involved in aromatic compounds catabolism
NicSoilB8_36510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NicSoilB8_36510	COG1017	nitric oxide dioxygenase activity
NicSoilB8_36580	COG1250	3-hydroxyacyl-CoA dehydrogenase
NicSoilB8_36590	COG1024	Enoyl-CoA hydratase
NicSoilB8_36600	COG0183	Belongs to the thiolase family
NicSoilB8_36680	COG1802	Transcriptional regulator
NicSoilB8_36710	COG3971	2-oxopent-4-enoate hydratase activity
NicSoilB8_36740	COG0488	(ABC) transporter
NicSoilB8_36770	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NicSoilB8_36840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NicSoilB8_36860	COG0785	Cytochrome C biogenesis protein
NicSoilB8_36870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NicSoilB8_36880	COG0406	alpha-ribazole phosphatase activity
NicSoilB8_36890	COG2353	YceI-like domain
NicSoilB8_36920	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NicSoilB8_36950	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NicSoilB8_36990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NicSoilB8_37010	COG0640	Transcriptional regulator
NicSoilB8_37020	COG0123	including yeast histone deacetylase and acetoin utilization protein
NicSoilB8_37030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NicSoilB8_37040	COG0569	domain protein
NicSoilB8_37060	COG4941	Belongs to the sigma-70 factor family
NicSoilB8_37080	COG0248	Ppx GppA phosphatase
NicSoilB8_37100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NicSoilB8_37100	COG1754	DNA topoisomerase type I activity
NicSoilB8_37180	COG1054	Belongs to the UPF0176 family
NicSoilB8_37200	COG1111	helicase
NicSoilB8_37200	COG1205	dead DEAH box helicase
NicSoilB8_37310	COG0494	nUDIX hydrolase
NicSoilB8_37340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NicSoilB8_37350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NicSoilB8_37420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NicSoilB8_37430	COG1408	metallophosphoesterase
NicSoilB8_37440	COG1132	(ABC) transporter
NicSoilB8_37450	COG1132	(ABC) transporter
NicSoilB8_37480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NicSoilB8_37490	COG0151	Belongs to the GarS family
NicSoilB8_37530	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_37560	COG3387	PFAM Glycoside hydrolase 15-related
NicSoilB8_37570	COG0667	Aldo Keto reductase
NicSoilB8_37670	COG0671	phosphoesterase, PA-phosphatase related
NicSoilB8_37690	COG0667	Aldo Keto reductase
NicSoilB8_37700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NicSoilB8_37790	COG0693	protein deglycase activity
NicSoilB8_37860	COG2197	response regulator
NicSoilB8_37930	COG2084	Dehydrogenase
NicSoilB8_37940	COG1082	Xylose isomerase domain protein TIM barrel
NicSoilB8_37950	COG0149	triose-phosphate isomerase activity
NicSoilB8_37960	COG0698	ribose 5-phosphate isomerase
NicSoilB8_37970	COG2376	Dihydroxyacetone kinase
NicSoilB8_38020	COG0673	inositol 2-dehydrogenase activity
NicSoilB8_38040	COG1175	transmembrane transport
NicSoilB8_38050	COG1653	transport
NicSoilB8_38060	COG1609	Transcriptional regulator
NicSoilB8_38070	COG1070	Carbohydrate kinase
NicSoilB8_38080	COG2115	Belongs to the xylose isomerase family
NicSoilB8_38090	COG0277	FAD linked oxidase domain protein
NicSoilB8_38100	COG1940	carbohydrate kinase activity
NicSoilB8_38110	COG2017	converts alpha-aldose to the beta-anomer
NicSoilB8_38130	COG0346	lactoylglutathione lyase activity
NicSoilB8_38150	COG0800	Aldolase
NicSoilB8_38170	COG0395	ABC-type sugar transport system, permease component
NicSoilB8_38180	COG1175	transmembrane transport
NicSoilB8_38200	COG1609	Transcriptional regulator
NicSoilB8_38220	COG4670	ketone body catabolic process
NicSoilB8_38240	COG1024	Enoyl-CoA hydratase
NicSoilB8_38250	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilB8_38260	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NicSoilB8_38290	COG4702	Belongs to the UPF0303 family
NicSoilB8_38320	COG0673	inositol 2-dehydrogenase activity
NicSoilB8_38330	COG1609	Transcriptional regulator
NicSoilB8_38360	COG2084	Dehydrogenase
NicSoilB8_38370	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NicSoilB8_38380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NicSoilB8_38390	COG0673	inositol 2-dehydrogenase activity
NicSoilB8_38430	COG0318	PFAM AMP-dependent synthetase and ligase
NicSoilB8_38440	COG2814	Major facilitator Superfamily
NicSoilB8_38450	COG1414	Transcriptional regulator
NicSoilB8_38460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NicSoilB8_38470	COG0477	Major facilitator Superfamily
NicSoilB8_38490	COG2508	Transcriptional regulator
NicSoilB8_38490	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NicSoilB8_38500	COG2066	Belongs to the glutaminase family
NicSoilB8_38520	COG0028	Belongs to the TPP enzyme family
NicSoilB8_38530	COG2986	histidine ammonia-lyase
NicSoilB8_38540	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_38560	COG2318	DinB family
NicSoilB8_38620	COG2130	NADP-dependent
NicSoilB8_38650	COG0251	oxidation-reduction process
NicSoilB8_38660	COG1126	abc transporter atp-binding protein
NicSoilB8_38670	COG0765	amino acid transport
NicSoilB8_38710	COG2508	Transcriptional regulator
NicSoilB8_38760	COG1063	alcohol dehydrogenase
NicSoilB8_38770	COG0395	ABC-type sugar transport system, permease component
NicSoilB8_38840	COG0546	phosphoglycolate phosphatase activity
NicSoilB8_38860	COG1063	alcohol dehydrogenase
NicSoilB8_38870	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_38890	COG4221	oxidoreductase activity
NicSoilB8_38900	COG0477	Major facilitator Superfamily
NicSoilB8_38920	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NicSoilB8_38930	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NicSoilB8_38940	COG0583	DNA-binding transcription factor activity
NicSoilB8_38960	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NicSoilB8_38970	COG0436	Aminotransferase
NicSoilB8_39010	COG3795	YCII-related domain
NicSoilB8_39020	COG1737	Transcriptional regulator
NicSoilB8_39040	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilB8_39070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NicSoilB8_39100	COG0174	glutamine synthetase
NicSoilB8_39140	COG0300	oxidoreductase activity
NicSoilB8_39160	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NicSoilB8_39220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NicSoilB8_39240	COG0179	Fumarylacetoacetate (FAA) hydrolase
NicSoilB8_39270	COG0583	DNA-binding transcription factor activity
NicSoilB8_39310	COG0673	inositol 2-dehydrogenase activity
NicSoilB8_39320	COG1940	carbohydrate kinase activity
NicSoilB8_39440	COG3622	Belongs to the hyi family
NicSoilB8_39460	COG0395	ABC-type sugar transport system, permease component
NicSoilB8_39540	COG3845	ABC transporter
NicSoilB8_39560	COG0646	methionine synthase
NicSoilB8_39560	COG1410	methionine synthase
NicSoilB8_39670	COG2022	thiamine diphosphate biosynthetic process
NicSoilB8_39690	COG0647	UMP catabolic process
NicSoilB8_39750	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NicSoilB8_39840	COG0191	fructose-bisphosphate aldolase activity
NicSoilB8_39850	COG0698	ribose 5-phosphate isomerase
NicSoilB8_39860	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NicSoilB8_39870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NicSoilB8_39880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NicSoilB8_39890	COG2197	response regulator
NicSoilB8_40010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NicSoilB8_40200	COG2076	Multidrug Resistance protein
NicSoilB8_40310	COG2828	Protein conserved in bacteria
NicSoilB8_40330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NicSoilB8_40340	COG0579	oxidoreductase
NicSoilB8_40360	COG0745	RESPONSE REGULATOR receiver
NicSoilB8_40370	COG5002	protein histidine kinase activity
NicSoilB8_40390	COG0438	transferase activity, transferring glycosyl groups
NicSoilB8_40400	COG0438	transferase activity, transferring glycosyl groups
NicSoilB8_40410	COG1132	(ABC) transporter
NicSoilB8_40490	COG2271	Major facilitator Superfamily
NicSoilB8_40500	COG1802	Transcriptional regulator
NicSoilB8_40520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NicSoilB8_40540	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NicSoilB8_40580	COG0667	Aldo Keto reductase
NicSoilB8_40590	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NicSoilB8_40610	COG3608	succinylglutamate desuccinylase aspartoacylase
NicSoilB8_40610	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NicSoilB8_40630	COG0590	tRNA wobble adenosine to inosine editing
NicSoilB8_40660	COG2233	PERMEase
NicSoilB8_40670	COG1414	Transcriptional regulator
NicSoilB8_40690	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NicSoilB8_40710	COG3257	ureidoglycine aminohydrolase activity
NicSoilB8_40730	COG3622	Belongs to the hyi family
NicSoilB8_40740	COG2084	Dehydrogenase
NicSoilB8_40750	COG3960	tartronate-semialdehyde synthase activity
NicSoilB8_40760	COG1929	Belongs to the glycerate kinase type-1 family
NicSoilB8_40770	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NicSoilB8_40780	COG0745	RESPONSE REGULATOR receiver
NicSoilB8_40830	COG2226	methyltransferase
NicSoilB8_40860	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NicSoilB8_40910	COG1609	Transcriptional regulator
NicSoilB8_40930	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_40940	COG3246	L-lysine catabolic process to acetate
NicSoilB8_40950	COG1929	Belongs to the glycerate kinase type-1 family
NicSoilB8_40960	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NicSoilB8_41000	COG3585	molybdate ion transport
NicSoilB8_41050	COG2353	YceI-like domain
NicSoilB8_41160	COG0135	phosphoribosylanthranilate isomerase activity
NicSoilB8_41180	COG1177	transmembrane transport
NicSoilB8_41190	COG1176	ABC-type spermidine putrescine transport system, permease component I
NicSoilB8_41200	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NicSoilB8_41210	COG3842	ATPase activity
NicSoilB8_41250	COG2076	Multidrug Resistance protein
NicSoilB8_41260	COG0667	Aldo Keto reductase
NicSoilB8_41280	COG0513	Belongs to the DEAD box helicase family
NicSoilB8_41300	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NicSoilB8_41410	COG1113	amino acid transport
NicSoilB8_41440	COG1473	amidohydrolase
NicSoilB8_41450	COG0477	Major facilitator Superfamily
NicSoilB8_41460	COG2807	transmembrane transport
NicSoilB8_41480	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NicSoilB8_41540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NicSoilB8_41570	COG3226	Transcriptional regulator
NicSoilB8_41590	COG0494	nUDIX hydrolase
NicSoilB8_41650	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilB8_41680	COG0789	Transcriptional regulator
NicSoilB8_41690	COG0484	heat shock protein binding
NicSoilB8_41700	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NicSoilB8_41710	COG0443	Heat shock 70 kDa protein
NicSoilB8_41750	COG2409	Drug exporters of the RND superfamily
NicSoilB8_41820	COG1280	lysine exporter protein (LysE YggA)
NicSoilB8_41840	COG0477	Major facilitator Superfamily
NicSoilB8_41860	COG1960	acyl-CoA dehydrogenase activity
NicSoilB8_41880	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_41900	COG3387	PFAM Glycoside hydrolase 15-related
NicSoilB8_41920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NicSoilB8_41940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NicSoilB8_42000	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NicSoilB8_42010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NicSoilB8_42030	COG1122	ATPase activity
NicSoilB8_42040	COG4721	ABC-type cobalt transport system, permease component
NicSoilB8_42050	COG4702	Belongs to the UPF0303 family
NicSoilB8_42080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NicSoilB8_42090	COG1320	monovalent cation:proton antiporter activity
NicSoilB8_42100	COG2212	antiporter activity
NicSoilB8_42110	COG1863	multisubunit Na H antiporter MnhE subunit
NicSoilB8_42120	COG0651	ATP synthesis coupled electron transport
NicSoilB8_42130	COG1006	Multisubunit Na H antiporter MnhC subunit
NicSoilB8_42140	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NicSoilB8_42140	COG2111	Na H antiporter
NicSoilB8_42170	COG0475	glutathione-regulated potassium exporter activity
NicSoilB8_42180	COG0717	Belongs to the dCTP deaminase family
NicSoilB8_42220	COG2814	Major facilitator Superfamily
NicSoilB8_42230	COG0583	DNA-binding transcription factor activity
NicSoilB8_42250	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilB8_42260	COG0531	amino acid
NicSoilB8_42280	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NicSoilB8_42320	COG3387	PFAM Glycoside hydrolase 15-related
NicSoilB8_42350	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
NicSoilB8_42370	COG1175	transmembrane transport
NicSoilB8_42390	COG1609	Transcriptional regulator
NicSoilB8_42430	COG0395	ABC-type sugar transport system, permease component
NicSoilB8_42450	COG1349	DNA-binding transcription factor activity
NicSoilB8_42480	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NicSoilB8_42490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilB8_42520	COG0433	COG0433 Predicted ATPase
NicSoilB8_42560	COG3336	cytochrome c oxidase
NicSoilB8_42570	COG0776	regulation of translation
NicSoilB8_42590	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NicSoilB8_42600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NicSoilB8_42610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NicSoilB8_42620	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NicSoilB8_42620	COG1017	nitric oxide dioxygenase activity
NicSoilB8_42740	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilB8_42770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NicSoilB8_42800	COG1960	acyl-CoA dehydrogenase activity
NicSoilB8_42810	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilB8_42820	COG1250	3-hydroxyacyl-CoA dehydrogenase
NicSoilB8_42830	COG2826	transposase and inactivated derivatives, IS30 family
NicSoilB8_42910	COG3012	SEC-C Motif Domain Protein
NicSoilB8_42930	COG0667	Aldo Keto reductase
NicSoilB8_42940	COG0702	epimerase
NicSoilB8_42970	COG0698	ribose 5-phosphate isomerase
NicSoilB8_42980	COG2376	Dihydroxyacetone kinase
NicSoilB8_42990	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilB8_43010	COG0477	Major facilitator Superfamily
NicSoilB8_43020	COG3959	Transketolase, thiamine diphosphate binding domain
NicSoilB8_43030	COG3958	Transketolase
NicSoilB8_43200	COG0039	L-malate dehydrogenase activity
NicSoilB8_43220	COG0640	Transcriptional regulator
NicSoilB8_43250	COG2186	Transcriptional regulator
NicSoilB8_43270	COG1027	Aspartate ammonia-lyase
NicSoilB8_43320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NicSoilB8_43340	COG1522	sequence-specific DNA binding
NicSoilB8_43350	COG1280	lysine exporter protein (LysE YggA)
NicSoilB8_43390	COG0281	malic enzyme
NicSoilB8_43400	COG1309	transcriptional regulator
NicSoilB8_43430	COG0477	Major facilitator Superfamily
NicSoilB8_43440	COG0477	Major facilitator Superfamily
NicSoilB8_43450	COG2814	Major facilitator Superfamily
NicSoilB8_43470	COG0246	Mannitol dehydrogenase
NicSoilB8_43480	COG2213	PTS system mannitol-specific
NicSoilB8_43480	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NicSoilB8_43500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NicSoilB8_43540	COG0686	Belongs to the AlaDH PNT family
NicSoilB8_43550	COG0673	inositol 2-dehydrogenase activity
NicSoilB8_43560	COG1309	transcriptional regulator
NicSoilB8_43580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NicSoilB8_43600	COG0318	PFAM AMP-dependent synthetase and ligase
NicSoilB8_43620	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilB8_43630	COG0022	dehydrogenase e1 component
NicSoilB8_43650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NicSoilB8_43660	COG1950	PFAM Membrane protein of
NicSoilB8_43690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NicSoilB8_43710	COG2902	Dehydrogenase
NicSoilB8_43730	COG1607	acyl-coa hydrolase
NicSoilB8_43770	COG2814	Major facilitator Superfamily
NicSoilB8_43790	COG1970	mechanosensitive ion channel activity
NicSoilB8_43850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NicSoilB8_43860	COG1088	dTDP-glucose 4,6-dehydratase activity
NicSoilB8_43870	COG0673	inositol 2-dehydrogenase activity
NicSoilB8_43900	COG1414	Transcriptional regulator
NicSoilB8_43910	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NicSoilB8_43930	COG0183	Belongs to the thiolase family
NicSoilB8_43940	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NicSoilB8_43960	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NicSoilB8_43970	COG3485	protocatechuate 3,4-dioxygenase
NicSoilB8_43980	COG3485	protocatechuate 3,4-dioxygenase
NicSoilB8_43990	COG1082	Xylose isomerase domain protein TIM barrel
NicSoilB8_43990	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NicSoilB8_44000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NicSoilB8_44010	COG1414	Transcriptional regulator
NicSoilB8_44030	COG1793	dna ligase
NicSoilB8_44050	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NicSoilB8_44090	COG1937	Protein conserved in bacteria
NicSoilB8_44130	COG0697	spore germination
NicSoilB8_44180	COG2259	Doxx family
NicSoilB8_44190	COG1607	acyl-coa hydrolase
NicSoilB8_44200	COG0305	Participates in initiation and elongation during chromosome replication
NicSoilB8_44270	COG0359	binds to the 23S rRNA
NicSoilB8_44280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NicSoilB8_44300	COG0360	Binds together with S18 to 16S ribosomal RNA
NicSoilB8_44320	COG2197	response regulator
NicSoilB8_44350	COG1215	transferase activity, transferring glycosyl groups
NicSoilB8_44380	COG1215	transferase activity, transferring glycosyl groups
NicSoilB8_44490	COG1362	aminopeptidase activity
NicSoilB8_44520	COG1113	amino acid transport
NicSoilB8_44530	COG2197	response regulator
NicSoilB8_44540	COG4585	Histidine kinase
NicSoilB8_44560	COG1131	(ABC) transporter
NicSoilB8_44580	COG0738	Major facilitator superfamily
NicSoilB8_44600	COG0488	(ABC) transporter
NicSoilB8_44620	COG2197	response regulator
NicSoilB8_44630	COG4585	Histidine kinase
NicSoilB8_44650	COG1136	(ABC) transporter
NicSoilB8_44680	COG0406	alpha-ribazole phosphatase activity
NicSoilB8_44690	COG0617	tRNA 3'-terminal CCA addition
NicSoilB8_44730	COG0492	ferredoxin-NADP+ reductase activity
NicSoilB8_44740	COG3118	belongs to the thioredoxin family
NicSoilB8_44770	COG1192	Involved in chromosome partitioning
NicSoilB8_44780	COG0357	Ribosomal RNA small subunit methyltransferase G
NicSoilB8_44800	COG0706	membrane insertase activity
NicSoilB8_44810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NicSoilB8_44820	COG0594	ribonuclease P activity
NicSoilB8_44830	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NicSoilB8_45160	COG2186	Transcriptional regulator
NicSoilB8_45170	COG0129	dihydroxy-acid dehydratase activity
NicSoilB8_45210	COG0561	phosphatase activity
NicSoilB8_45220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NicSoilB8_45240	COG3387	PFAM Glycoside hydrolase 15-related
NicSoilB8_45250	COG2902	Dehydrogenase
NicSoilB8_45260	COG3547	Transposase (IS116 IS110 IS902 family)
NicSoilB8_45290	COG0154	amidase activity
NicSoilB8_45320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NicSoilB8_45360	COG3547	Transposase (IS116 IS110 IS902 family)
NicSoilB8_45400	COG2233	PERMEase
NicSoilB8_45410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NicSoilB8_45420	COG0509	glycine decarboxylation via glycine cleavage system
NicSoilB8_45430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NicSoilB8_45450	COG1879	ABC-type sugar transport system periplasmic component
NicSoilB8_45460	COG0402	S-adenosylhomocysteine deaminase activity
NicSoilB8_45490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NicSoilB8_45500	COG2233	PERMEase
NicSoilB8_45550	COG1733	regulation of RNA biosynthetic process
NicSoilB8_45560	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NicSoilB8_45610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NicSoilB8_45620	COG3246	L-lysine catabolic process to acetate
NicSoilB8_45630	COG0318	PFAM AMP-dependent synthetase and ligase
NicSoilB8_45640	COG0113	porphobilinogen synthase activity
NicSoilB8_45660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NicSoilB8_45700	COG3253	May function as heme-dependent peroxidase
NicSoilB8_45820	COG1074	ATP-dependent DNA helicase activity
NicSoilB8_45890	COG2186	Transcriptional regulator
NicSoilB8_45970	COG2826	transposase and inactivated derivatives, IS30 family
NicSoilB8_46060	COG2233	PERMEase
NicSoilB8_46070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NicSoilB8_46100	COG0402	S-adenosylhomocysteine deaminase activity
NicSoilB8_46110	COG1879	ABC-type sugar transport system periplasmic component
NicSoilB8_46120	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NicSoilB8_46120	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NicSoilB8_46130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NicSoilB8_46140	COG0509	glycine decarboxylation via glycine cleavage system
NicSoilB8_46150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NicSoilB8_46170	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NicSoilB8_46190	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NicSoilB8_46200	COG2233	PERMEase
NicSoilB8_46240	COG0113	porphobilinogen synthase activity
NicSoilB8_46250	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NicSoilB8_46340	COG2814	Major facilitator Superfamily
NicSoilB8_46440	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NicSoilB8_46640	COG3706	GGDEF domain
NicSoilB8_46670	COG3979	chitinase
NicSoilB8_46690	COG3979	chitinase
NicSoilB8_46830	COG2135	peptidase activity
NicSoilB8_46860	COG3547	Transposase (IS116 IS110 IS902 family)
NicSoilB8_46940	COG4152	abc transporter atp-binding protein
NicSoilB8_46980	COG1475	DNA binding
NicSoilB8_47160	COG0659	secondary active sulfate transmembrane transporter activity
NicSoilB8_47190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids