locus-tag	class	description
NicSoilC5_00010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NicSoilC5_00020	COG1120	ATPase activity
NicSoilC5_00100	COG1017	nitric oxide dioxygenase activity
NicSoilC5_00100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NicSoilC5_00110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NicSoilC5_00120	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NicSoilC5_00130	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NicSoilC5_00140	COG1609	Transcriptional regulator
NicSoilC5_00180	COG0647	UMP catabolic process
NicSoilC5_00210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NicSoilC5_00220	COG0497	DNA recombination
NicSoilC5_00230	COG0504	CTP synthase activity
NicSoilC5_00240	COG0494	nUDIX hydrolase
NicSoilC5_00300	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NicSoilC5_00310	COG2079	MmgE PrpD family protein
NicSoilC5_00350	COG3290	protein histidine kinase activity
NicSoilC5_00380	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NicSoilC5_00390	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NicSoilC5_00420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NicSoilC5_00440	COG1160	GTP binding
NicSoilC5_00460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NicSoilC5_00470	COG0509	glycine decarboxylation via glycine cleavage system
NicSoilC5_00480	COG1716	ATPase activity
NicSoilC5_00530	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NicSoilC5_00540	COG0464	growth
NicSoilC5_00560	COG1940	carbohydrate kinase activity
NicSoilC5_00610	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NicSoilC5_00620	COG0515	serine threonine protein kinase
NicSoilC5_00620	COG2815	serine threonine protein kinase
NicSoilC5_00630	COG1388	LysM domain
NicSoilC5_00630	COG3942	CHAP domain
NicSoilC5_00650	COG0142	geranyltranstransferase activity
NicSoilC5_00670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NicSoilC5_00690	COG2001	Belongs to the MraZ family
NicSoilC5_00700	COG0275	rRNA processing
NicSoilC5_00720	COG0768	penicillin binding
NicSoilC5_00730	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NicSoilC5_00750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NicSoilC5_00760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NicSoilC5_00770	COG0772	Belongs to the SEDS family
NicSoilC5_00780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NicSoilC5_00790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NicSoilC5_00810	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NicSoilC5_00830	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NicSoilC5_00840	COG1799	cell septum assembly
NicSoilC5_00860	COG3599	regulation of cell shape
NicSoilC5_00870	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NicSoilC5_00890	COG0587	DNA-directed DNA polymerase activity
NicSoilC5_00920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NicSoilC5_00930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NicSoilC5_00970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NicSoilC5_00980	COG0174	glutamine synthetase
NicSoilC5_00990	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NicSoilC5_01050	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NicSoilC5_01060	COG0321	lipoyl(octanoyl) transferase activity
NicSoilC5_01080	COG1090	epimerase
NicSoilC5_01090	COG0793	Belongs to the peptidase S41A family
NicSoilC5_01090	COG4946	Tricorn protease homolog
NicSoilC5_01100	COG1764	response to oxidative stress
NicSoilC5_01120	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilC5_01130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NicSoilC5_01140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NicSoilC5_01180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NicSoilC5_01240	COG1271	oxidase subunit
NicSoilC5_01250	COG1294	oxidase, subunit
NicSoilC5_01260	COG4988	ABC transporter
NicSoilC5_01280	COG1131	(ABC) transporter
NicSoilC5_01290	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NicSoilC5_01300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NicSoilC5_01300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NicSoilC5_01330	COG1435	thymidine kinase activity
NicSoilC5_01380	COG0756	dUTP diphosphatase activity
NicSoilC5_01430	COG0569	domain protein
NicSoilC5_01440	COG0531	amino acid
NicSoilC5_01450	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NicSoilC5_01460	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NicSoilC5_01470	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NicSoilC5_01500	COG0667	Aldo Keto reductase
NicSoilC5_01540	COG1122	ATPase activity
NicSoilC5_01550	COG1250	3-hydroxyacyl-CoA dehydrogenase
NicSoilC5_01550	COG1024	Enoyl-CoA hydratase
NicSoilC5_01560	COG0183	Belongs to the thiolase family
NicSoilC5_01570	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NicSoilC5_01620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NicSoilC5_01650	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilC5_01660	COG0300	oxidoreductase activity
NicSoilC5_01670	COG2132	Multicopper oxidase
NicSoilC5_01680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NicSoilC5_01720	COG3135	benzoate transporter
NicSoilC5_01750	COG0242	peptide deformylase activity
NicSoilC5_01760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NicSoilC5_01780	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NicSoilC5_01810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NicSoilC5_01810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NicSoilC5_01830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NicSoilC5_01840	COG0140	phosphoribosyl-ATP diphosphatase activity
NicSoilC5_01850	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NicSoilC5_01860	COG0107	imidazoleglycerol-phosphate synthase activity
NicSoilC5_01880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NicSoilC5_01920	COG0134	indole-3-glycerol-phosphate synthase activity
NicSoilC5_01930	COG0133	tryptophan synthase activity
NicSoilC5_01940	COG0159	tryptophan synthase activity
NicSoilC5_01950	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NicSoilC5_01960	COG0067	glutamate synthase
NicSoilC5_01960	COG0069	glutamate synthase activity
NicSoilC5_01960	COG0070	glutamate synthase
NicSoilC5_01980	COG0469	pyruvate kinase activity
NicSoilC5_02190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NicSoilC5_02290	COG1609	Transcriptional regulator
NicSoilC5_02300	COG2211	Major facilitator Superfamily
NicSoilC5_02580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NicSoilC5_02600	COG3608	succinylglutamate desuccinylase aspartoacylase
NicSoilC5_02600	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NicSoilC5_02670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NicSoilC5_02800	COG2755	lipolytic protein G-D-S-L family
NicSoilC5_02830	COG1349	DNA-binding transcription factor activity
NicSoilC5_02860	COG0477	Major facilitator Superfamily
NicSoilC5_02880	COG0800	Aldolase
NicSoilC5_02900	COG1609	Transcriptional regulator
NicSoilC5_02960	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_02980	COG0395	ABC-type sugar transport system, permease component
NicSoilC5_03530	COG1472	Belongs to the glycosyl hydrolase 3 family
NicSoilC5_03540	COG3250	beta-galactosidase activity
NicSoilC5_03550	COG2814	Major facilitator Superfamily
NicSoilC5_03590	COG3250	beta-galactosidase activity
NicSoilC5_03610	COG1175	transmembrane transport
NicSoilC5_03620	COG0395	ABC-type sugar transport system, permease component
NicSoilC5_03630	COG4952	isomerase
NicSoilC5_03640	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_03640	COG3347	Dehydrogenase
NicSoilC5_03680	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_03690	COG4638	Rieske (2fe-2S)
NicSoilC5_03710	COG0633	Ferredoxin
NicSoilC5_03780	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilC5_03790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NicSoilC5_03830	COG1309	transcriptional regulator
NicSoilC5_03870	COG3619	membrane
NicSoilC5_04040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NicSoilC5_04040	COG0574	Belongs to the PEP-utilizing enzyme family
NicSoilC5_04080	COG0439	Biotin carboxylase
NicSoilC5_04090	COG0511	ligase activity, forming carbon-carbon bonds
NicSoilC5_04120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NicSoilC5_04140	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_04150	COG1414	Transcriptional regulator
NicSoilC5_04160	COG2814	Major facilitator Superfamily
NicSoilC5_04170	COG3485	protocatechuate 3,4-dioxygenase
NicSoilC5_04180	COG0667	Aldo Keto reductase
NicSoilC5_04190	COG1454	alcohol dehydrogenase
NicSoilC5_04200	COG4214	carbohydrate transport
NicSoilC5_04220	COG4213	ABC transporter substrate-binding protein
NicSoilC5_04230	COG1414	Transcriptional regulator
NicSoilC5_04240	COG0673	inositol 2-dehydrogenase activity
NicSoilC5_04260	COG0673	inositol 2-dehydrogenase activity
NicSoilC5_04290	COG0183	Belongs to the thiolase family
NicSoilC5_04310	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NicSoilC5_04320	COG1017	nitric oxide dioxygenase activity
NicSoilC5_04320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NicSoilC5_04400	COG2154	pterin-4-alpha-carbinolamine dehydratase
NicSoilC5_04430	COG1850	ribulose-bisphosphate carboxylase activity
NicSoilC5_04450	COG1063	alcohol dehydrogenase
NicSoilC5_04480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NicSoilC5_04490	COG0667	Aldo Keto reductase
NicSoilC5_04500	COG1621	beta-fructofuranosidase activity
NicSoilC5_04520	COG0395	ABC-type sugar transport system, permease component
NicSoilC5_04530	COG4209	transmembrane transport
NicSoilC5_04580	COG0395	ABC-type sugar transport system, permease component
NicSoilC5_04590	COG1063	alcohol dehydrogenase
NicSoilC5_04630	COG1268	BioY protein
NicSoilC5_04690	COG0395	ABC-type sugar transport system, permease component
NicSoilC5_04700	COG1175	transmembrane transport
NicSoilC5_04730	COG1609	Transcriptional regulator
NicSoilC5_04750	COG1621	beta-fructofuranosidase activity
NicSoilC5_04770	COG0444	Belongs to the ABC transporter superfamily
NicSoilC5_04780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NicSoilC5_04790	COG0601	transmembrane transport
NicSoilC5_04800	COG0747	negative chemotaxis
NicSoilC5_04820	COG0667	Aldo Keto reductase
NicSoilC5_04830	COG1621	beta-fructofuranosidase activity
NicSoilC5_04910	COG2197	response regulator
NicSoilC5_04940	COG1063	alcohol dehydrogenase
NicSoilC5_04950	COG0583	DNA-binding transcription factor activity
NicSoilC5_05000	COG3383	formate dehydrogenase (NAD+) activity
NicSoilC5_05000	COG0243	molybdopterin cofactor binding
NicSoilC5_05010	COG3383	formate dehydrogenase (NAD+) activity
NicSoilC5_05010	COG0243	molybdopterin cofactor binding
NicSoilC5_05020	COG0437	4 iron, 4 sulfur cluster binding
NicSoilC5_05040	COG0709	Synthesizes selenophosphate from selenide and ATP
NicSoilC5_05090	COG2124	cytochrome p450
NicSoilC5_05130	COG3386	PFAM SMP-30 Gluconolaconase
NicSoilC5_05140	COG0667	Aldo Keto reductase
NicSoilC5_05160	COG2268	Band 7 protein
NicSoilC5_05170	COG0477	Major facilitator Superfamily
NicSoilC5_05180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NicSoilC5_05190	COG1024	Enoyl-CoA hydratase
NicSoilC5_05200	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_05230	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NicSoilC5_05260	COG0406	alpha-ribazole phosphatase activity
NicSoilC5_05280	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NicSoilC5_05320	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NicSoilC5_05330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NicSoilC5_05360	COG1643	Atp-dependent helicase
NicSoilC5_05390	COG0009	L-threonylcarbamoyladenylate synthase
NicSoilC5_05490	COG2050	protein possibly involved in aromatic compounds catabolism
NicSoilC5_05510	COG4552	Acetyltransferase involved in intracellular survival and related
NicSoilC5_05520	COG0539	negative regulation of cytoplasmic translation
NicSoilC5_05540	COG1739	Uncharacterized protein family UPF0029
NicSoilC5_05550	COG0237	dephospho-CoA kinase activity
NicSoilC5_05550	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NicSoilC5_05560	COG0556	nucleotide-excision repair
NicSoilC5_05580	COG0477	Major facilitator Superfamily
NicSoilC5_05620	COG4106	trans-aconitate 2-methyltransferase activity
NicSoilC5_05680	COG0204	Acyl-transferase
NicSoilC5_05680	COG0318	PFAM AMP-dependent synthetase and ligase
NicSoilC5_05690	COG0322	excinuclease ABC activity
NicSoilC5_05700	COG1660	Displays ATPase and GTPase activities
NicSoilC5_05710	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NicSoilC5_05720	COG1481	regulation of sporulation
NicSoilC5_05730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NicSoilC5_05740	COG0126	phosphoglycerate kinase activity
NicSoilC5_05750	COG0149	triose-phosphate isomerase activity
NicSoilC5_05760	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NicSoilC5_05780	COG0363	glucosamine-6-phosphate deaminase activity
NicSoilC5_05810	COG0166	Belongs to the GPI family
NicSoilC5_05820	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NicSoilC5_05840	COG0109	protoheme IX farnesyltransferase activity
NicSoilC5_05850	COG0659	secondary active sulfate transmembrane transporter activity
NicSoilC5_05860	COG1612	heme a metabolic process
NicSoilC5_05880	COG1131	(ABC) transporter
NicSoilC5_05930	COG0396	ATPase activity
NicSoilC5_05940	COG2151	metal-sulfur cluster biosynthetic enzyme
NicSoilC5_05960	COG0318	PFAM AMP-dependent synthetase and ligase
NicSoilC5_05990	COG1122	ATPase activity
NicSoilC5_06000	COG1268	BioY protein
NicSoilC5_06020	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NicSoilC5_06050	COG2354	Protein conserved in bacteria
NicSoilC5_06070	COG0488	(ABC) transporter
NicSoilC5_06120	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_06130	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_06140	COG3830	Belongs to the UPF0237 family
NicSoilC5_06140	COG0560	Phosphoserine phosphatase
NicSoilC5_06150	COG1119	ATPase activity
NicSoilC5_06180	COG0254	rRNA binding
NicSoilC5_06220	COG2855	membrane
NicSoilC5_06250	COG1305	Transglutaminase-like
NicSoilC5_06280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NicSoilC5_06300	COG0297	glycogen (starch) synthase activity
NicSoilC5_06340	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_06380	COG0435	Glutathione S-transferase
NicSoilC5_06450	COG1063	alcohol dehydrogenase
NicSoilC5_06530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NicSoilC5_06570	COG0656	L-ascorbic acid biosynthetic process
NicSoilC5_06580	COG1968	undecaprenyl-diphosphatase activity
NicSoilC5_06590	COG0215	cysteine-tRNA ligase activity
NicSoilC5_06610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NicSoilC5_06620	COG1994	Peptidase M50
NicSoilC5_06620	COG0517	IMP dehydrogenase activity
NicSoilC5_06640	COG1222	aaa ATPase
NicSoilC5_06650	COG4122	O-methyltransferase activity
NicSoilC5_06670	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NicSoilC5_06680	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NicSoilC5_06690	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NicSoilC5_06700	COG0545	Peptidyl-prolyl cis-trans isomerase
NicSoilC5_06740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NicSoilC5_06750	COG0805	protein transport
NicSoilC5_06760	COG4581	dead DEAH box helicase
NicSoilC5_06770	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NicSoilC5_06780	COG1216	Glycosyl transferase, family 2
NicSoilC5_06830	COG0242	peptide deformylase activity
NicSoilC5_06850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NicSoilC5_06860	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NicSoilC5_06910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NicSoilC5_06920	COG1845	cytochrome c oxidase, subunit III
NicSoilC5_06930	COG2010	Cytochrome c
NicSoilC5_06940	COG0723	plastoquinol--plastocyanin reductase activity
NicSoilC5_06950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NicSoilC5_06990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NicSoilC5_07000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NicSoilC5_07050	COG0167	dihydroorotate dehydrogenase activity
NicSoilC5_07070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NicSoilC5_07080	COG1381	Involved in DNA repair and RecF pathway recombination
NicSoilC5_07090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NicSoilC5_07100	COG3590	peptidase
NicSoilC5_07110	COG1316	TRANSCRIPTIONal
NicSoilC5_07120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NicSoilC5_07140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NicSoilC5_07170	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NicSoilC5_07180	COG0484	heat shock protein binding
NicSoilC5_07190	COG1420	regulation of RNA biosynthetic process
NicSoilC5_07230	COG0481	GTPase activity
NicSoilC5_07250	COG0268	Binds directly to 16S ribosomal RNA
NicSoilC5_07290	COG1555	photosystem II stabilization
NicSoilC5_07330	COG1307	EDD domain protein, DegV family
NicSoilC5_07340	COG0495	leucyl-tRNA aminoacylation
NicSoilC5_07350	COG0723	plastoquinol--plastocyanin reductase activity
NicSoilC5_07360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NicSoilC5_07370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NicSoilC5_07380	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NicSoilC5_07390	COG2390	Transcriptional regulator
NicSoilC5_07400	COG0656	L-ascorbic acid biosynthetic process
NicSoilC5_07420	COG0438	transferase activity, transferring glycosyl groups
NicSoilC5_07450	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NicSoilC5_07470	COG1758	RNA polymerase activity
NicSoilC5_07480	COG0194	GDP metabolic process
NicSoilC5_07490	COG0194	GDP metabolic process
NicSoilC5_07500	COG0284	orotidine-5'-phosphate decarboxylase activity
NicSoilC5_07510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NicSoilC5_07520	COG0505	Belongs to the CarA family
NicSoilC5_07540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NicSoilC5_07550	COG0540	Belongs to the ATCase OTCase family
NicSoilC5_07560	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NicSoilC5_07580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NicSoilC5_07590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NicSoilC5_07610	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NicSoilC5_07620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NicSoilC5_07630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NicSoilC5_07640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NicSoilC5_07670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NicSoilC5_07700	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NicSoilC5_07750	COG1053	succinate dehydrogenase
NicSoilC5_07770	COG0477	Major facilitator Superfamily
NicSoilC5_07790	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NicSoilC5_07810	COG0124	histidyl-tRNA synthetase
NicSoilC5_07820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NicSoilC5_07830	COG1196	nuclear chromosome segregation
NicSoilC5_07850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NicSoilC5_07860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NicSoilC5_07870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NicSoilC5_07890	COG2255	four-way junction helicase activity
NicSoilC5_07900	COG0632	four-way junction helicase activity
NicSoilC5_07910	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NicSoilC5_07920	COG0217	transcriptional regulatory protein
NicSoilC5_07930	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NicSoilC5_07940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NicSoilC5_07960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NicSoilC5_07980	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NicSoilC5_07990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NicSoilC5_08010	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NicSoilC5_08020	COG0587	DNA-directed DNA polymerase activity
NicSoilC5_08050	COG1605	Chorismate mutase
NicSoilC5_08050	COG0077	Prephenate dehydratase
NicSoilC5_08070	COG2135	peptidase activity
NicSoilC5_08100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NicSoilC5_08110	COG1695	Transcriptional regulator
NicSoilC5_08170	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_08230	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NicSoilC5_08240	COG1234	tRNA 3'-trailer cleavage
NicSoilC5_08280	COG0589	response to stress
NicSoilC5_08420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NicSoilC5_08440	COG0574	Belongs to the PEP-utilizing enzyme family
NicSoilC5_08440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NicSoilC5_08450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NicSoilC5_08470	COG2217	Heavy metal translocating P-type atpase
NicSoilC5_08630	COG1842	Phage shock protein A
NicSoilC5_08710	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NicSoilC5_08730	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NicSoilC5_09120	COG3209	COG3209 Rhs family protein
NicSoilC5_09220	COG4152	abc transporter atp-binding protein
NicSoilC5_09310	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NicSoilC5_09320	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NicSoilC5_09330	COG1780	Probably involved in ribonucleotide reductase function
NicSoilC5_09360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NicSoilC5_09390	COG0583	DNA-binding transcription factor activity
NicSoilC5_09420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NicSoilC5_09430	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NicSoilC5_09480	COG0714	Associated with various cellular activities
NicSoilC5_09510	COG1175	transmembrane transport
NicSoilC5_09540	COG2813	Specifically methylates the guanine in position
NicSoilC5_09550	COG0492	ferredoxin-NADP+ reductase activity
NicSoilC5_09560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NicSoilC5_09590	COG0799	negative regulation of ribosome biogenesis
NicSoilC5_09610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NicSoilC5_09630	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NicSoilC5_09640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NicSoilC5_09650	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NicSoilC5_09660	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NicSoilC5_09670	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NicSoilC5_09680	COG0351	phosphomethylpyrimidine kinase
NicSoilC5_09680	COG0352	thiamine-phosphate diphosphorylase activity
NicSoilC5_09680	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NicSoilC5_09690	COG1530	ribonuclease E activity
NicSoilC5_09710	COG0105	UTP biosynthetic process
NicSoilC5_09730	COG0285	dihydrofolate synthase activity
NicSoilC5_09740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NicSoilC5_09770	COG0525	valine-tRNA ligase activity
NicSoilC5_09780	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NicSoilC5_09790	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NicSoilC5_09800	COG0740	serine-type endopeptidase activity
NicSoilC5_09810	COG0740	serine-type endopeptidase activity
NicSoilC5_09820	COG0544	peptidyl-prolyl cis-trans isomerase activity
NicSoilC5_09890	COG0668	transmembrane transport
NicSoilC5_09920	COG1946	Acyl-CoA thioesterase
NicSoilC5_09970	COG0629	single-stranded DNA binding
NicSoilC5_10040	COG1475	DNA binding
NicSoilC5_10430	COG4974	Belongs to the 'phage' integrase family
NicSoilC5_10460	COG2115	Belongs to the xylose isomerase family
NicSoilC5_10470	COG1070	Carbohydrate kinase
NicSoilC5_10500	COG0673	inositol 2-dehydrogenase activity
NicSoilC5_10510	COG1609	Transcriptional regulator
NicSoilC5_10520	COG0657	acetylesterase activity
NicSoilC5_10520	COG2755	lipolytic protein G-D-S-L family
NicSoilC5_10530	COG2017	converts alpha-aldose to the beta-anomer
NicSoilC5_10560	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NicSoilC5_10570	COG0242	peptide deformylase activity
NicSoilC5_10620	COG3022	response to hydroperoxide
NicSoilC5_10640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NicSoilC5_10650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NicSoilC5_10670	COG1045	serine acetyltransferase
NicSoilC5_10680	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_10690	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NicSoilC5_10750	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NicSoilC5_10780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NicSoilC5_10790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NicSoilC5_10800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NicSoilC5_10820	COG4974	Belongs to the 'phage' integrase family
NicSoilC5_10850	COG0792	nuclease activity
NicSoilC5_10870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NicSoilC5_10890	COG0681	Belongs to the peptidase S26 family
NicSoilC5_10900	COG0335	large ribosomal subunit rRNA binding
NicSoilC5_10910	COG0336	Belongs to the RNA methyltransferase TrmD family
NicSoilC5_10920	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NicSoilC5_10930	COG1837	Belongs to the UPF0109 family
NicSoilC5_10940	COG0228	four-way junction DNA binding
NicSoilC5_10960	COG2514	catechol 2,3-dioxygenase activity
NicSoilC5_11010	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NicSoilC5_11040	COG2814	Major facilitator Superfamily
NicSoilC5_11070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NicSoilC5_11080	COG0318	PFAM AMP-dependent synthetase and ligase
NicSoilC5_11090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NicSoilC5_11140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NicSoilC5_11150	COG0571	ribonuclease III activity
NicSoilC5_11160	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NicSoilC5_11180	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NicSoilC5_11210	COG0742	ribosomal rna small subunit methyltransferase
NicSoilC5_11220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NicSoilC5_11230	COG1461	Dihydroxyacetone kinase
NicSoilC5_11260	COG1181	Belongs to the D-alanine--D-alanine ligase family
NicSoilC5_11270	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NicSoilC5_11290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NicSoilC5_11300	COG0066	3-isopropylmalate dehydratase activity
NicSoilC5_11310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NicSoilC5_11320	COG1414	Transcriptional regulator
NicSoilC5_11400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NicSoilC5_11410	COG0179	Fumarylacetoacetate (FAA) hydrolase
NicSoilC5_11420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NicSoilC5_11440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NicSoilC5_11450	COG0473	3-isopropylmalate dehydrogenase activity
NicSoilC5_11470	COG1136	(ABC) transporter
NicSoilC5_11470	COG0577	efflux transmembrane transporter activity
NicSoilC5_11490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NicSoilC5_11500	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NicSoilC5_11510	COG0440	acetolactate synthase activity
NicSoilC5_11530	COG0129	dihydroxy-acid dehydratase activity
NicSoilC5_11540	COG0088	Forms part of the polypeptide exit tunnel
NicSoilC5_11600	COG0747	negative chemotaxis
NicSoilC5_11610	COG0579	oxidoreductase
NicSoilC5_11620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NicSoilC5_11630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilC5_11650	COG1305	Transglutaminase-like
NicSoilC5_11690	COG1104	cysteine desulfurase activity
NicSoilC5_11710	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NicSoilC5_11720	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NicSoilC5_11740	COG1113	amino acid transport
NicSoilC5_11760	COG0477	Major facilitator Superfamily
NicSoilC5_11790	COG0419	ATPase involved in DNA repair
NicSoilC5_11800	COG0420	3'-5' exonuclease activity
NicSoilC5_11850	COG0586	Pfam SNARE associated Golgi protein
NicSoilC5_11860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NicSoilC5_11870	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NicSoilC5_11880	COG1234	tRNA 3'-trailer cleavage
NicSoilC5_11890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NicSoilC5_11910	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NicSoilC5_11930	COG1335	isochorismatase
NicSoilC5_11960	COG0363	glucosamine-6-phosphate deaminase activity
NicSoilC5_12010	COG1902	pentaerythritol trinitrate reductase activity
NicSoilC5_12050	COG0628	permease
NicSoilC5_12080	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
NicSoilC5_12100	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NicSoilC5_12110	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NicSoilC5_12130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NicSoilC5_12140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NicSoilC5_12150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NicSoilC5_12160	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NicSoilC5_12170	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NicSoilC5_12180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NicSoilC5_12190	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NicSoilC5_12200	COG0356	it plays a direct role in the translocation of protons across the membrane
NicSoilC5_12240	COG1216	Glycosyl transferase, family 2
NicSoilC5_12270	COG2890	protein-(glutamine-N5) methyltransferase activity
NicSoilC5_12280	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NicSoilC5_12300	COG0083	homoserine kinase activity
NicSoilC5_12310	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NicSoilC5_12320	COG0460	homoserine dehydrogenase
NicSoilC5_12330	COG0019	diaminopimelate decarboxylase activity
NicSoilC5_12340	COG0018	arginyl-trna synthetase
NicSoilC5_12370	COG1017	nitric oxide dioxygenase activity
NicSoilC5_12370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NicSoilC5_12410	COG1643	Atp-dependent helicase
NicSoilC5_12420	COG0537	adenosine 5'-monophosphoramidase activity
NicSoilC5_12430	COG1064	alcohol dehydrogenase
NicSoilC5_12450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NicSoilC5_12490	COG3842	ATPase activity
NicSoilC5_12500	COG0803	Belongs to the bacterial solute-binding protein 9 family
NicSoilC5_12530	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilC5_12530	COG0567	Dehydrogenase, E1 component
NicSoilC5_12580	COG1595	DNA-templated transcription, initiation
NicSoilC5_12600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NicSoilC5_12620	COG0483	inositol monophosphate 1-phosphatase activity
NicSoilC5_12630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NicSoilC5_12670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NicSoilC5_12700	COG1063	alcohol dehydrogenase
NicSoilC5_12760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NicSoilC5_12790	COG2884	Cell division ATP-binding protein ftsE
NicSoilC5_12800	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NicSoilC5_12880	COG5479	isomerase activity
NicSoilC5_12880	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NicSoilC5_12890	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NicSoilC5_12900	COG1088	dTDP-glucose 4,6-dehydratase activity
NicSoilC5_12920	COG1216	Glycosyl transferase, family 2
NicSoilC5_12950	COG1215	transferase activity, transferring glycosyl groups
NicSoilC5_13050	COG1216	Glycosyl transferase, family 2
NicSoilC5_13120	COG2902	Dehydrogenase
NicSoilC5_13190	COG0653	protein targeting
NicSoilC5_13200	COG3214	Protein conserved in bacteria
NicSoilC5_13210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NicSoilC5_13230	COG5401	PFAM Sporulation and spore germination
NicSoilC5_13240	COG5002	protein histidine kinase activity
NicSoilC5_13300	COG0714	Associated with various cellular activities
NicSoilC5_13370	COG0601	transmembrane transport
NicSoilC5_13390	COG0482	sulfurtransferase activity
NicSoilC5_13440	COG0484	heat shock protein binding
NicSoilC5_13450	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NicSoilC5_13460	COG1595	DNA-templated transcription, initiation
NicSoilC5_13490	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NicSoilC5_13500	COG2086	electron transfer activity
NicSoilC5_13510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NicSoilC5_13530	COG1842	Phage shock protein A
NicSoilC5_13540	COG0415	Belongs to the DNA photolyase family
NicSoilC5_13560	COG1615	UPF0182 protein
NicSoilC5_13570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NicSoilC5_13610	COG2816	NAD+ diphosphatase activity
NicSoilC5_13630	COG0210	DNA helicase
NicSoilC5_13670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NicSoilC5_13680	COG0765	amino acid transport
NicSoilC5_13690	COG1126	abc transporter atp-binding protein
NicSoilC5_13700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NicSoilC5_13720	COG0113	porphobilinogen synthase activity
NicSoilC5_13740	COG0181	hydroxymethylbilane synthase activity
NicSoilC5_13750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NicSoilC5_13760	COG3253	May function as heme-dependent peroxidase
NicSoilC5_13800	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NicSoilC5_13810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NicSoilC5_13860	COG2022	thiamine diphosphate biosynthetic process
NicSoilC5_13880	COG2022	thiamine diphosphate biosynthetic process
NicSoilC5_13880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NicSoilC5_13890	COG0352	thiamine-phosphate diphosphorylase activity
NicSoilC5_13900	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
NicSoilC5_13910	COG0513	Belongs to the DEAD box helicase family
NicSoilC5_13920	COG2189	Belongs to the N(4) N(6)-methyltransferase family
NicSoilC5_13940	COG0006	proline dipeptidase activity
NicSoilC5_13960	COG2239	Acts as a magnesium transporter
NicSoilC5_13990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NicSoilC5_14010	COG1595	DNA-templated transcription, initiation
NicSoilC5_14020	COG4122	O-methyltransferase activity
NicSoilC5_14060	COG1611	Belongs to the LOG family
NicSoilC5_14070	COG1126	abc transporter atp-binding protein
NicSoilC5_14080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NicSoilC5_14090	COG0765	amino acid transport
NicSoilC5_14100	COG0765	amino acid transport
NicSoilC5_14110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NicSoilC5_14120	COG2171	N-acyltransferase activity
NicSoilC5_14150	COG3226	Transcriptional regulator
NicSoilC5_14160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NicSoilC5_14220	COG1217	gtp-binding protein TYPA
NicSoilC5_14250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NicSoilC5_14270	COG4166	transmembrane transport
NicSoilC5_14290	COG3152	Membrane
NicSoilC5_14300	COG0012	GTP binding
NicSoilC5_14310	COG1322	Protein conserved in bacteria
NicSoilC5_14320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NicSoilC5_14340	COG1570	exodeoxyribonuclease VII activity
NicSoilC5_14350	COG1722	exodeoxyribonuclease VII activity
NicSoilC5_14360	COG2326	polyphosphate kinase activity
NicSoilC5_14390	COG1174	glycine betaine transport
NicSoilC5_14400	COG1174	glycine betaine transport
NicSoilC5_14410	COG0517	IMP dehydrogenase activity
NicSoilC5_14410	COG1125	glycine betaine transport
NicSoilC5_14430	COG2971	BadF BadG BcrA BcrD
NicSoilC5_14440	COG0583	DNA-binding transcription factor activity
NicSoilC5_14450	COG2814	Major facilitator Superfamily
NicSoilC5_14490	COG0598	Magnesium transport protein CorA
NicSoilC5_14520	COG3848	Pyruvate phosphate dikinase
NicSoilC5_14520	COG0574	Belongs to the PEP-utilizing enzyme family
NicSoilC5_14560	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NicSoilC5_14570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NicSoilC5_14610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NicSoilC5_14610	COG0519	Catalyzes the synthesis of GMP from XMP
NicSoilC5_14650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NicSoilC5_14660	COG0516	GMP reductase activity
NicSoilC5_14730	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NicSoilC5_14730	COG2755	lipolytic protein G-D-S-L family
NicSoilC5_14750	COG1793	dna ligase
NicSoilC5_14770	COG0459	protein refolding
NicSoilC5_14780	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NicSoilC5_14810	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NicSoilC5_14820	COG1472	Belongs to the glycosyl hydrolase 3 family
NicSoilC5_14840	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NicSoilC5_14850	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NicSoilC5_14880	COG0802	atpase or kinase
NicSoilC5_14890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NicSoilC5_14920	COG0438	transferase activity, transferring glycosyl groups
NicSoilC5_14930	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NicSoilC5_14960	COG0667	Aldo Keto reductase
NicSoilC5_15010	COG0736	holo-[acyl-carrier-protein] synthase activity
NicSoilC5_15040	COG1072	(Pantothenic acid kinase))
NicSoilC5_15050	COG1876	peptidase activity
NicSoilC5_15060	COG1970	mechanosensitive ion channel activity
NicSoilC5_15070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NicSoilC5_15100	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NicSoilC5_15110	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NicSoilC5_15110	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NicSoilC5_15120	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NicSoilC5_15130	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NicSoilC5_15200	COG2894	cell division
NicSoilC5_15290	COG1192	Involved in chromosome partitioning
NicSoilC5_15360	COG0101	tRNA pseudouridine synthase activity
NicSoilC5_15370	COG0203	ribosomal protein L17
NicSoilC5_15380	COG0202	RNA polymerase activity
NicSoilC5_15390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NicSoilC5_15400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NicSoilC5_15410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NicSoilC5_15420	COG3191	aminopeptidase activity
NicSoilC5_15470	COG0563	adenylate kinase activity
NicSoilC5_15490	COG0200	Binds to the 23S rRNA
NicSoilC5_15500	COG1841	ribosomal large subunit assembly
NicSoilC5_15510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NicSoilC5_15520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NicSoilC5_15530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NicSoilC5_15540	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NicSoilC5_15550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NicSoilC5_15560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NicSoilC5_15570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NicSoilC5_15580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NicSoilC5_15590	COG0255	Belongs to the universal ribosomal protein uL29 family
NicSoilC5_15600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NicSoilC5_15610	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NicSoilC5_15620	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NicSoilC5_15630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NicSoilC5_15640	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NicSoilC5_15650	COG0089	rRNA binding
NicSoilC5_15660	COG0088	Forms part of the polypeptide exit tunnel
NicSoilC5_15670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NicSoilC5_15680	COG0051	transcription antitermination factor activity, RNA binding
NicSoilC5_15720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NicSoilC5_15730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NicSoilC5_15740	COG0049	tRNA binding
NicSoilC5_15750	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NicSoilC5_15760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NicSoilC5_15770	COG0085	RNA polymerase activity
NicSoilC5_15800	COG0183	Belongs to the thiolase family
NicSoilC5_15810	COG0442	prolyl-tRNA aminoacylation
NicSoilC5_15820	COG0222	ribosome binding
NicSoilC5_15830	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NicSoilC5_15860	COG0081	regulation of translation
NicSoilC5_15870	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NicSoilC5_15900	COG0436	Aminotransferase
NicSoilC5_15910	COG2197	response regulator
NicSoilC5_16020	COG3485	protocatechuate 3,4-dioxygenase
NicSoilC5_16050	COG0745	RESPONSE REGULATOR receiver
NicSoilC5_16060	COG0456	acetyltransferase
NicSoilC5_16070	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NicSoilC5_16100	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NicSoilC5_16110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NicSoilC5_16160	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NicSoilC5_16190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NicSoilC5_16200	COG0738	Major facilitator superfamily
NicSoilC5_16220	COG2030	dehydratase
NicSoilC5_16240	COG0659	secondary active sulfate transmembrane transporter activity
NicSoilC5_16280	COG4989	oxidoreductase activity
NicSoilC5_16290	COG0366	Alpha amylase catalytic
NicSoilC5_16300	COG1940	carbohydrate kinase activity
NicSoilC5_16320	COG0702	epimerase
NicSoilC5_16370	COG0706	membrane insertase activity
NicSoilC5_16410	COG0754	glutathionylspermidine amidase activity
NicSoilC5_16440	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_16490	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NicSoilC5_16560	COG0318	PFAM AMP-dependent synthetase and ligase
NicSoilC5_16580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NicSoilC5_16600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NicSoilC5_16640	COG1666	GTP binding
NicSoilC5_16670	COG2837	iron assimilation
NicSoilC5_16680	COG0501	Belongs to the peptidase M48B family
NicSoilC5_16730	COG0531	amino acid
NicSoilC5_16870	COG1215	transferase activity, transferring glycosyl groups
NicSoilC5_16900	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilC5_16910	COG3835	regulator
NicSoilC5_16940	COG2186	Transcriptional regulator
NicSoilC5_17000	COG1648	precorrin-2 dehydrogenase activity
NicSoilC5_17000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NicSoilC5_17030	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NicSoilC5_17050	COG1690	Belongs to the RtcB family
NicSoilC5_17080	COG2895	sulfate adenylyltransferase (ATP) activity
NicSoilC5_17100	COG0175	sulfate reduction
NicSoilC5_17110	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NicSoilC5_17130	COG2860	membrane
NicSoilC5_17160	COG0142	geranyltranstransferase activity
NicSoilC5_17180	COG2226	methyltransferase
NicSoilC5_17190	COG1169	isochorismate synthase
NicSoilC5_17210	COG0765	amino acid transport
NicSoilC5_17220	COG1126	abc transporter atp-binding protein
NicSoilC5_17230	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NicSoilC5_17240	COG1609	Transcriptional regulator
NicSoilC5_17250	COG1621	beta-fructofuranosidase activity
NicSoilC5_17260	COG0395	ABC-type sugar transport system, permease component
NicSoilC5_17270	COG1175	transmembrane transport
NicSoilC5_17310	COG4948	Mandelate Racemase Muconate Lactonizing
NicSoilC5_17320	COG0598	Magnesium transport protein CorA
NicSoilC5_17340	COG3559	Exporter of polyketide antibiotics
NicSoilC5_17350	COG1131	(ABC) transporter
NicSoilC5_17490	COG1309	transcriptional regulator
NicSoilC5_17520	COG2072	flavoprotein involved in K transport
NicSoilC5_17590	COG0492	ferredoxin-NADP+ reductase activity
NicSoilC5_17620	COG1846	Transcriptional regulator
NicSoilC5_17660	COG1316	TRANSCRIPTIONal
NicSoilC5_17690	COG2755	lipolytic protein G-D-S-L family
NicSoilC5_17690	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NicSoilC5_17720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NicSoilC5_17730	COG3795	YCII-related domain
NicSoilC5_17740	COG4941	Belongs to the sigma-70 factor family
NicSoilC5_17750	COG1215	transferase activity, transferring glycosyl groups
NicSoilC5_17770	COG2188	Transcriptional regulator
NicSoilC5_17790	COG1597	lipid kinase activity
NicSoilC5_17800	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilC5_17810	COG0022	dehydrogenase e1 component
NicSoilC5_17910	COG0438	transferase activity, transferring glycosyl groups
NicSoilC5_17930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NicSoilC5_18000	COG0745	RESPONSE REGULATOR receiver
NicSoilC5_18100	COG0076	glutamate decarboxylase activity
NicSoilC5_18110	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NicSoilC5_18150	COG1304	FMN binding
NicSoilC5_18240	COG0110	maltose O-acetyltransferase activity
NicSoilC5_18260	COG0489	protein tyrosine kinase activity
NicSoilC5_18310	COG0438	transferase activity, transferring glycosyl groups
NicSoilC5_18340	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NicSoilC5_18380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NicSoilC5_18400	COG0489	protein tyrosine kinase activity
NicSoilC5_18450	COG1024	Enoyl-CoA hydratase
NicSoilC5_18460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NicSoilC5_18470	COG2151	metal-sulfur cluster biosynthetic enzyme
NicSoilC5_18480	COG3396	Phenylacetate-CoA oxygenase
NicSoilC5_18490	COG3460	Phenylacetate-CoA oxygenase
NicSoilC5_18500	COG3396	Phenylacetate-CoA oxygenase
NicSoilC5_18530	COG0671	phosphoesterase, PA-phosphatase related
NicSoilC5_18560	COG5002	protein histidine kinase activity
NicSoilC5_18580	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NicSoilC5_18630	COG0156	8-amino-7-oxononanoate synthase activity
NicSoilC5_18660	COG3604	Transcriptional regulator
NicSoilC5_18680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NicSoilC5_18740	COG0667	Aldo Keto reductase
NicSoilC5_18760	COG0300	oxidoreductase activity
NicSoilC5_18820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NicSoilC5_18840	COG0640	Transcriptional regulator
NicSoilC5_18870	COG1247	-acetyltransferase
NicSoilC5_18900	COG0390	transport system, permease component
NicSoilC5_18910	COG2353	YceI-like domain
NicSoilC5_18940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NicSoilC5_18950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NicSoilC5_18990	COG1937	Protein conserved in bacteria
NicSoilC5_19000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NicSoilC5_19030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NicSoilC5_19100	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilC5_19110	COG0022	dehydrogenase e1 component
NicSoilC5_19120	COG0022	dehydrogenase e1 component
NicSoilC5_19120	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilC5_19130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NicSoilC5_19140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NicSoilC5_19200	COG0277	FAD linked oxidase domain protein
NicSoilC5_19210	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NicSoilC5_19270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NicSoilC5_19280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NicSoilC5_19310	COG3842	ATPase activity
NicSoilC5_19330	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NicSoilC5_19360	COG2217	Heavy metal translocating P-type atpase
NicSoilC5_19390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NicSoilC5_19400	COG1316	TRANSCRIPTIONal
NicSoilC5_19420	COG0406	alpha-ribazole phosphatase activity
NicSoilC5_19430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NicSoilC5_19440	COG0071	Belongs to the small heat shock protein (HSP20) family
NicSoilC5_19530	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NicSoilC5_19580	COG4948	Mandelate Racemase Muconate Lactonizing
NicSoilC5_19590	COG1802	Transcriptional regulator
NicSoilC5_19600	COG2271	Major facilitator Superfamily
NicSoilC5_19610	COG0280	phosphate acetyltransferase
NicSoilC5_19610	COG0857	belongs to the CobB CobQ family
NicSoilC5_19620	COG2050	protein possibly involved in aromatic compounds catabolism
NicSoilC5_19650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NicSoilC5_19680	COG2030	dehydratase
NicSoilC5_19680	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilC5_19690	COG2050	protein possibly involved in aromatic compounds catabolism
NicSoilC5_19770	COG1250	3-hydroxyacyl-CoA dehydrogenase
NicSoilC5_19780	COG1024	Enoyl-CoA hydratase
NicSoilC5_19850	COG1266	CAAX protease self-immunity
NicSoilC5_19870	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NicSoilC5_19970	COG0443	Heat shock 70 kDa protein
NicSoilC5_19980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NicSoilC5_20000	COG0785	Cytochrome C biogenesis protein
NicSoilC5_20010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NicSoilC5_20020	COG0406	alpha-ribazole phosphatase activity
NicSoilC5_20040	COG2353	YceI-like domain
NicSoilC5_20060	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NicSoilC5_20100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NicSoilC5_20120	COG3458	cephalosporin-C deacetylase activity
NicSoilC5_20130	COG1070	Carbohydrate kinase
NicSoilC5_20140	COG3347	Dehydrogenase
NicSoilC5_20140	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_20150	COG4952	isomerase
NicSoilC5_20170	COG1609	Transcriptional regulator
NicSoilC5_20220	COG0395	ABC-type sugar transport system, permease component
NicSoilC5_20230	COG4209	transmembrane transport
NicSoilC5_20240	COG1653	transport
NicSoilC5_20250	COG5578	integral membrane protein
NicSoilC5_20270	COG2814	Major facilitator Superfamily
NicSoilC5_20290	COG0395	ABC-type sugar transport system, permease component
NicSoilC5_20300	COG1175	transmembrane transport
NicSoilC5_20350	COG0395	ABC-type sugar transport system, permease component
NicSoilC5_20360	COG1175	transmembrane transport
NicSoilC5_20400	COG0673	inositol 2-dehydrogenase activity
NicSoilC5_20430	COG4948	Mandelate Racemase Muconate Lactonizing
NicSoilC5_20440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NicSoilC5_20450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NicSoilC5_20460	COG0673	inositol 2-dehydrogenase activity
NicSoilC5_20490	COG2190	(PTS) system
NicSoilC5_20490	COG2211	Major facilitator Superfamily
NicSoilC5_20510	COG2186	Transcriptional regulator
NicSoilC5_20530	COG0640	Transcriptional regulator
NicSoilC5_20540	COG0123	including yeast histone deacetylase and acetoin utilization protein
NicSoilC5_20550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NicSoilC5_20560	COG0569	domain protein
NicSoilC5_20570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NicSoilC5_20580	COG0248	Ppx GppA phosphatase
NicSoilC5_20600	COG1754	DNA topoisomerase type I activity
NicSoilC5_20600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NicSoilC5_20610	COG2890	protein-(glutamine-N5) methyltransferase activity
NicSoilC5_20640	COG1054	Belongs to the UPF0176 family
NicSoilC5_20660	COG1205	dead DEAH box helicase
NicSoilC5_20660	COG1111	helicase
NicSoilC5_20780	COG0494	nUDIX hydrolase
NicSoilC5_20810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NicSoilC5_20820	COG1349	DNA-binding transcription factor activity
NicSoilC5_20830	COG1609	Transcriptional regulator
NicSoilC5_20850	COG4209	transmembrane transport
NicSoilC5_20860	COG0395	ABC-type sugar transport system, permease component
NicSoilC5_20890	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NicSoilC5_20930	COG0395	ABC-type sugar transport system, permease component
NicSoilC5_20940	COG1175	transmembrane transport
NicSoilC5_20970	COG1609	Transcriptional regulator
NicSoilC5_21010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NicSoilC5_21020	COG1408	metallophosphoesterase
NicSoilC5_21030	COG1132	(ABC) transporter
NicSoilC5_21040	COG1132	(ABC) transporter
NicSoilC5_21070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NicSoilC5_21080	COG0151	Belongs to the GarS family
NicSoilC5_21150	COG1953	Uracil, thiamine, allantoin
NicSoilC5_21160	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NicSoilC5_21200	COG0667	Aldo Keto reductase
NicSoilC5_21210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NicSoilC5_21230	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NicSoilC5_21230	COG3608	succinylglutamate desuccinylase aspartoacylase
NicSoilC5_21240	COG2252	PERMEase
NicSoilC5_21250	COG0590	tRNA wobble adenosine to inosine editing
NicSoilC5_21280	COG3285	dna ligase
NicSoilC5_21280	COG1793	dna ligase
NicSoilC5_21320	COG2233	PERMEase
NicSoilC5_21330	COG1414	Transcriptional regulator
NicSoilC5_21350	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NicSoilC5_21370	COG3257	ureidoglycine aminohydrolase activity
NicSoilC5_21400	COG0546	phosphoglycolate phosphatase activity
NicSoilC5_21420	COG3387	PFAM Glycoside hydrolase 15-related
NicSoilC5_21470	COG0484	heat shock protein binding
NicSoilC5_21480	COG0071	Belongs to the small heat shock protein (HSP20) family
NicSoilC5_21490	COG0789	Transcriptional regulator
NicSoilC5_21520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NicSoilC5_21530	COG0563	adenylate kinase activity
NicSoilC5_21550	COG0745	RESPONSE REGULATOR receiver
NicSoilC5_21560	COG2267	carboxylic ester hydrolase activity
NicSoilC5_21570	COG0640	Transcriptional regulator
NicSoilC5_21610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilC5_21630	COG0579	oxidoreductase
NicSoilC5_21710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NicSoilC5_21710	COG4499	WXG100 protein secretion system (Wss), protein YukC
NicSoilC5_21900	COG2070	2-Nitropropane dioxygenase
NicSoilC5_21910	COG1064	alcohol dehydrogenase
NicSoilC5_21920	COG1063	alcohol dehydrogenase
NicSoilC5_21960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NicSoilC5_21970	COG1116	anion transmembrane transporter activity
NicSoilC5_21980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilC5_22040	COG0129	dihydroxy-acid dehydratase activity
NicSoilC5_22090	COG2508	Transcriptional regulator
NicSoilC5_22130	COG0477	Major facilitator Superfamily
NicSoilC5_22150	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilC5_22160	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_22180	COG1024	Enoyl-CoA hydratase
NicSoilC5_22190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NicSoilC5_22210	COG0477	Major facilitator Superfamily
NicSoilC5_22220	COG1396	sequence-specific DNA binding
NicSoilC5_22280	COG0640	Transcriptional regulator
NicSoilC5_22310	COG2200	EAL domain
NicSoilC5_22310	COG2199	diguanylate cyclase activity
NicSoilC5_22310	COG2203	Gaf domain
NicSoilC5_22370	COG0454	-acetyltransferase
NicSoilC5_22390	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NicSoilC5_22400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NicSoilC5_22460	COG1960	acyl-CoA dehydrogenase activity
NicSoilC5_22490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NicSoilC5_22510	COG1960	acyl-CoA dehydrogenase activity
NicSoilC5_22550	COG0477	Major facilitator Superfamily
NicSoilC5_22580	COG2807	transmembrane transport
NicSoilC5_22600	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NicSoilC5_22610	COG4251	negative regulation of phosphorylation
NicSoilC5_22630	COG2329	Antibiotic biosynthesis monooxygenase
NicSoilC5_22650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NicSoilC5_22660	COG2197	response regulator
NicSoilC5_22670	COG4585	Histidine kinase
NicSoilC5_22690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NicSoilC5_22760	COG3401	FG-GAP repeat protein
NicSoilC5_22830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NicSoilC5_22990	COG1473	amidohydrolase
NicSoilC5_23000	COG0477	Major facilitator Superfamily
NicSoilC5_23020	COG3622	Belongs to the hyi family
NicSoilC5_23030	COG2084	Dehydrogenase
NicSoilC5_23040	COG3960	tartronate-semialdehyde synthase activity
NicSoilC5_23050	COG1929	Belongs to the glycerate kinase type-1 family
NicSoilC5_23060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NicSoilC5_23130	COG0745	RESPONSE REGULATOR receiver
NicSoilC5_23150	COG1366	Belongs to the anti-sigma-factor antagonist family
NicSoilC5_23180	COG2351	hydroxyisourate hydrolase activity
NicSoilC5_23190	COG1414	Transcriptional regulator
NicSoilC5_23200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NicSoilC5_23220	COG1802	Transcriptional regulator
NicSoilC5_23250	COG3404	Formiminotransferase-cyclodeaminase
NicSoilC5_23260	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NicSoilC5_23280	COG2271	Major facilitator Superfamily
NicSoilC5_23330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NicSoilC5_23380	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NicSoilC5_23400	COG2267	carboxylic ester hydrolase activity
NicSoilC5_23470	COG3585	molybdate ion transport
NicSoilC5_23500	COG3304	Inner membrane component domain
NicSoilC5_23510	COG0135	phosphoribosylanthranilate isomerase activity
NicSoilC5_23540	COG2076	Multidrug Resistance protein
NicSoilC5_23560	COG0667	Aldo Keto reductase
NicSoilC5_23620	COG2807	transmembrane transport
NicSoilC5_23640	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NicSoilC5_23770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NicSoilC5_23810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NicSoilC5_23830	COG0069	glutamate synthase activity
NicSoilC5_23840	COG2218	PFAM glutamate synthase alpha subunit domain protein
NicSoilC5_23850	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NicSoilC5_23870	COG0673	inositol 2-dehydrogenase activity
NicSoilC5_23930	COG3226	Transcriptional regulator
NicSoilC5_23980	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NicSoilC5_24040	COG1309	transcriptional regulator
NicSoilC5_24050	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilC5_24060	COG1115	amino acid carrier protein
NicSoilC5_24070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NicSoilC5_24080	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NicSoilC5_24090	COG2271	Major facilitator Superfamily
NicSoilC5_24100	COG1802	Transcriptional regulator
NicSoilC5_24130	COG1760	l-serine dehydratase
NicSoilC5_24180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NicSoilC5_24200	COG2801	Transposase and inactivated derivatives
NicSoilC5_24200	COG3415	Transposase
NicSoilC5_24220	COG1846	Transcriptional regulator
NicSoilC5_24220	COG1940	carbohydrate kinase activity
NicSoilC5_24240	COG1175	transmembrane transport
NicSoilC5_24250	COG0395	ABC-type sugar transport system, permease component
NicSoilC5_24280	COG1605	Chorismate mutase
NicSoilC5_24280	COG0077	Prephenate dehydratase
NicSoilC5_24340	COG3971	2-oxopent-4-enoate hydratase activity
NicSoilC5_24370	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilC5_24390	COG0789	Transcriptional regulator
NicSoilC5_24400	COG0484	heat shock protein binding
NicSoilC5_24410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NicSoilC5_24420	COG0443	Heat shock 70 kDa protein
NicSoilC5_24430	COG0640	Transcriptional regulator
NicSoilC5_24440	COG2814	Major facilitator Superfamily
NicSoilC5_24480	COG2409	Drug exporters of the RND superfamily
NicSoilC5_24510	COG1280	lysine exporter protein (LysE YggA)
NicSoilC5_24520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NicSoilC5_24550	COG2814	Major facilitator Superfamily
NicSoilC5_24560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NicSoilC5_24670	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NicSoilC5_24680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NicSoilC5_24700	COG1122	ATPase activity
NicSoilC5_24710	COG4721	ABC-type cobalt transport system, permease component
NicSoilC5_24720	COG4702	Belongs to the UPF0303 family
NicSoilC5_24760	COG1320	monovalent cation:proton antiporter activity
NicSoilC5_24770	COG2212	antiporter activity
NicSoilC5_24790	COG0651	ATP synthesis coupled electron transport
NicSoilC5_24800	COG1006	Multisubunit Na H antiporter MnhC subunit
NicSoilC5_24810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NicSoilC5_24810	COG2111	Na H antiporter
NicSoilC5_24840	COG0475	glutathione-regulated potassium exporter activity
NicSoilC5_24850	COG0717	Belongs to the dCTP deaminase family
NicSoilC5_24910	COG0583	DNA-binding transcription factor activity
NicSoilC5_24930	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilC5_24940	COG0531	amino acid
NicSoilC5_24950	COG0583	DNA-binding transcription factor activity
NicSoilC5_24960	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NicSoilC5_25000	COG2814	Major facilitator Superfamily
NicSoilC5_25010	COG3387	PFAM Glycoside hydrolase 15-related
NicSoilC5_25020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilC5_25030	COG0667	Aldo Keto reductase
NicSoilC5_25050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NicSoilC5_25070	COG2814	Major facilitator Superfamily
NicSoilC5_25080	COG0583	DNA-binding transcription factor activity
NicSoilC5_25140	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
NicSoilC5_25150	COG4638	Rieske (2fe-2S)
NicSoilC5_25160	COG3485	protocatechuate 3,4-dioxygenase
NicSoilC5_25200	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilC5_25250	COG3845	ABC transporter
NicSoilC5_25280	COG1410	methionine synthase
NicSoilC5_25280	COG0646	methionine synthase
NicSoilC5_25310	COG2267	carboxylic ester hydrolase activity
NicSoilC5_25360	COG1802	Transcriptional regulator
NicSoilC5_25380	COG3842	ATPase activity
NicSoilC5_25400	COG1840	ABC-type Fe3 transport system, periplasmic component
NicSoilC5_25420	COG0583	DNA-binding transcription factor activity
NicSoilC5_25430	COG2828	Protein conserved in bacteria
NicSoilC5_25440	COG1301	dicarboxylic acid transport
NicSoilC5_25450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilC5_25460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilC5_25490	COG1126	abc transporter atp-binding protein
NicSoilC5_25500	COG0765	amino acid transport
NicSoilC5_25530	COG0433	COG0433 Predicted ATPase
NicSoilC5_25570	COG3336	cytochrome c oxidase
NicSoilC5_25580	COG0776	regulation of translation
NicSoilC5_25600	COG1609	Transcriptional regulator
NicSoilC5_25610	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NicSoilC5_25620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NicSoilC5_25630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NicSoilC5_25640	COG1017	nitric oxide dioxygenase activity
NicSoilC5_25640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NicSoilC5_25720	COG1120	ATPase activity
NicSoilC5_25730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NicSoilC5_25740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NicSoilC5_25840	COG3012	SEC-C Motif Domain Protein
NicSoilC5_25860	COG0667	Aldo Keto reductase
NicSoilC5_25940	COG0671	phosphoesterase, PA-phosphatase related
NicSoilC5_25950	COG0586	Pfam SNARE associated Golgi protein
NicSoilC5_25960	COG2186	Transcriptional regulator
NicSoilC5_25980	COG1027	Aspartate ammonia-lyase
NicSoilC5_26000	COG0405	Gamma-glutamyltransferase
NicSoilC5_26010	COG0039	L-malate dehydrogenase activity
NicSoilC5_26020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NicSoilC5_26050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NicSoilC5_26090	COG1522	sequence-specific DNA binding
NicSoilC5_26100	COG1280	lysine exporter protein (LysE YggA)
NicSoilC5_26150	COG1309	transcriptional regulator
NicSoilC5_26180	COG0477	Major facilitator Superfamily
NicSoilC5_26190	COG0477	Major facilitator Superfamily
NicSoilC5_26200	COG2814	Major facilitator Superfamily
NicSoilC5_26230	COG0246	Mannitol dehydrogenase
NicSoilC5_26240	COG2213	PTS system mannitol-specific
NicSoilC5_26240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NicSoilC5_26260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NicSoilC5_26280	COG0596	Alpha beta hydrolase
NicSoilC5_26300	COG0686	Belongs to the AlaDH PNT family
NicSoilC5_26310	COG0673	inositol 2-dehydrogenase activity
NicSoilC5_26370	COG0431	NADPH-dependent FMN reductase
NicSoilC5_26390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NicSoilC5_26430	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilC5_26440	COG0022	dehydrogenase e1 component
NicSoilC5_26460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NicSoilC5_26520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NicSoilC5_26530	COG0406	alpha-ribazole phosphatase activity
NicSoilC5_26540	COG0515	serine threonine protein kinase
NicSoilC5_26540	COG2815	serine threonine protein kinase
NicSoilC5_26580	COG1607	acyl-coa hydrolase
NicSoilC5_26590	COG1840	ABC-type Fe3 transport system, periplasmic component
NicSoilC5_26600	COG3842	ATPase activity
NicSoilC5_26610	COG1178	ABC-type Fe3 transport system permease component
NicSoilC5_26690	COG2271	Major facilitator Superfamily
NicSoilC5_26700	COG1802	Transcriptional regulator
NicSoilC5_26740	COG1597	lipid kinase activity
NicSoilC5_26780	COG2186	Transcriptional regulator
NicSoilC5_26790	COG2159	amidohydrolase
NicSoilC5_26810	COG1414	Transcriptional regulator
NicSoilC5_26820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NicSoilC5_26830	COG0477	Major facilitator Superfamily
NicSoilC5_26840	COG1414	Transcriptional regulator
NicSoilC5_26850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NicSoilC5_26870	COG0183	Belongs to the thiolase family
NicSoilC5_26880	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NicSoilC5_26910	COG3485	protocatechuate 3,4-dioxygenase
NicSoilC5_26920	COG3485	protocatechuate 3,4-dioxygenase
NicSoilC5_26930	COG1082	Xylose isomerase domain protein TIM barrel
NicSoilC5_26930	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NicSoilC5_26940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NicSoilC5_26950	COG1414	Transcriptional regulator
NicSoilC5_26960	COG0477	Major facilitator Superfamily
NicSoilC5_26970	COG1793	dna ligase
NicSoilC5_27020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NicSoilC5_27030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NicSoilC5_27060	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilC5_27070	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NicSoilC5_27090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NicSoilC5_27160	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NicSoilC5_27220	COG1937	Protein conserved in bacteria
NicSoilC5_27320	COG2259	Doxx family
NicSoilC5_27340	COG0305	Participates in initiation and elongation during chromosome replication
NicSoilC5_27390	COG0359	binds to the 23S rRNA
NicSoilC5_27400	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NicSoilC5_27420	COG0360	Binds together with S18 to 16S ribosomal RNA
NicSoilC5_27450	COG2244	polysaccharide biosynthetic process
NicSoilC5_27470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NicSoilC5_27500	COG1216	Glycosyl transferase, family 2
NicSoilC5_27520	COG0463	Glycosyl transferase, family 2
NicSoilC5_27550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NicSoilC5_27560	COG0673	inositol 2-dehydrogenase activity
NicSoilC5_27570	COG1088	dTDP-glucose 4,6-dehydratase activity
NicSoilC5_27580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NicSoilC5_27680	COG1362	aminopeptidase activity
NicSoilC5_27690	COG1113	amino acid transport
NicSoilC5_27730	COG0738	Major facilitator superfamily
NicSoilC5_27750	COG0488	(ABC) transporter
NicSoilC5_27760	COG0768	penicillin binding
NicSoilC5_27800	COG0406	alpha-ribazole phosphatase activity
NicSoilC5_27810	COG0617	tRNA 3'-terminal CCA addition
NicSoilC5_27850	COG0492	ferredoxin-NADP+ reductase activity
NicSoilC5_27860	COG3118	belongs to the thioredoxin family
NicSoilC5_27900	COG1192	Involved in chromosome partitioning
NicSoilC5_27910	COG0357	Ribosomal RNA small subunit methyltransferase G
NicSoilC5_27930	COG0706	membrane insertase activity
NicSoilC5_27940	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NicSoilC5_27950	COG0594	ribonuclease P activity
NicSoilC5_27960	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NicSoilC5_27970	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NicSoilC5_27980	COG0592	DNA-directed DNA polymerase activity
NicSoilC5_27990	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NicSoilC5_28000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NicSoilC5_28010	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
NicSoilC5_28020	COG0187	DNA topoisomerase II activity
NicSoilC5_28030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NicSoilC5_28040	COG3266	domain, Protein
NicSoilC5_28070	COG1215	transferase activity, transferring glycosyl groups
NicSoilC5_28110	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NicSoilC5_28120	COG2818	Glycosylase
NicSoilC5_28140	COG3764	Sortase (surface protein transpeptidase)
NicSoilC5_28170	COG0515	serine threonine protein kinase
NicSoilC5_28180	COG0515	serine threonine protein kinase
NicSoilC5_28220	COG1716	ATPase activity
NicSoilC5_28230	COG1716	ATPase activity
NicSoilC5_28260	COG2130	NADP-dependent
NicSoilC5_28320	COG0346	lactoylglutathione lyase activity
NicSoilC5_28400	COG0277	FAD linked oxidase domain protein
NicSoilC5_28410	COG0154	amidase activity
NicSoilC5_28420	COG2957	Belongs to the agmatine deiminase family
NicSoilC5_28440	COG1162	GTPase activity
NicSoilC5_28470	COG0477	Major facilitator Superfamily
NicSoilC5_28510	COG3706	GGDEF domain
NicSoilC5_28550	COG0673	inositol 2-dehydrogenase activity
NicSoilC5_28570	COG1175	transmembrane transport
NicSoilC5_28580	COG1653	transport
NicSoilC5_28610	COG2084	Dehydrogenase
NicSoilC5_28620	COG1082	Xylose isomerase domain protein TIM barrel
NicSoilC5_28630	COG0149	triose-phosphate isomerase activity
NicSoilC5_28640	COG0698	ribose 5-phosphate isomerase
NicSoilC5_28650	COG2376	Dihydroxyacetone kinase
NicSoilC5_28670	COG2186	Transcriptional regulator
NicSoilC5_28680	COG1609	Transcriptional regulator
NicSoilC5_28690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NicSoilC5_28700	COG0765	amino acid transport
NicSoilC5_28710	COG1126	abc transporter atp-binding protein
NicSoilC5_28720	COG0673	inositol 2-dehydrogenase activity
NicSoilC5_28740	COG0659	secondary active sulfate transmembrane transporter activity
NicSoilC5_28810	COG2084	Dehydrogenase
NicSoilC5_28830	COG0477	Major facilitator Superfamily
NicSoilC5_28900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NicSoilC5_28970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NicSoilC5_29030	COG2084	Dehydrogenase
NicSoilC5_29070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NicSoilC5_29090	COG0460	homoserine dehydrogenase
NicSoilC5_29110	COG1609	Transcriptional regulator
NicSoilC5_29120	COG1957	nucleoside hydrolase
NicSoilC5_29130	COG0477	Major facilitator Superfamily
NicSoilC5_29140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NicSoilC5_29150	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_29160	COG1846	Transcriptional regulator
NicSoilC5_29160	COG1940	carbohydrate kinase activity
NicSoilC5_29170	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
NicSoilC5_29180	COG3842	ATPase activity
NicSoilC5_29200	COG1175	transmembrane transport
NicSoilC5_29300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NicSoilC5_29330	COG0561	phosphatase activity
NicSoilC5_29380	COG2199	diguanylate cyclase activity
NicSoilC5_29380	COG2200	EAL domain
NicSoilC5_29380	COG2203	Gaf domain
NicSoilC5_29400	COG5002	protein histidine kinase activity
NicSoilC5_29430	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_29440	COG1929	Belongs to the glycerate kinase type-1 family
NicSoilC5_29470	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_29500	COG0823	Involved in the tonB-independent uptake of proteins
NicSoilC5_29520	COG0673	inositol 2-dehydrogenase activity
NicSoilC5_29530	COG0673	inositol 2-dehydrogenase activity
NicSoilC5_29550	COG0395	ABC-type sugar transport system, permease component
NicSoilC5_29650	COG2233	PERMEase
NicSoilC5_29660	COG0778	Nitroreductase
NicSoilC5_29700	COG0583	DNA-binding transcription factor activity
NicSoilC5_29730	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NicSoilC5_29740	COG2186	Transcriptional regulator
NicSoilC5_29760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NicSoilC5_29780	COG5416	Lipopolysaccharide assembly protein A domain
NicSoilC5_29820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NicSoilC5_29850	COG1597	lipid kinase activity
NicSoilC5_29860	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NicSoilC5_29880	COG0561	phosphatase activity
NicSoilC5_29990	COG0037	tRNA processing
NicSoilC5_30010	COG1609	Transcriptional regulator
NicSoilC5_30020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NicSoilC5_30030	COG0302	gtp cyclohydrolase
NicSoilC5_30040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NicSoilC5_30050	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NicSoilC5_30110	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NicSoilC5_30150	COG0693	protein deglycase activity
NicSoilC5_30160	COG2814	Major facilitator Superfamily
NicSoilC5_30180	COG1309	transcriptional regulator
NicSoilC5_30210	COG3665	Urea carboxylase-associated protein
NicSoilC5_30250	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NicSoilC5_30290	COG0823	Involved in the tonB-independent uptake of proteins
NicSoilC5_30290	COG1506	peptidase
NicSoilC5_30300	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NicSoilC5_30310	COG2376	Dihydroxyacetone kinase
NicSoilC5_30320	COG1461	Dihydroxyacetone kinase
NicSoilC5_30330	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
NicSoilC5_30400	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NicSoilC5_30430	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NicSoilC5_30470	COG5002	protein histidine kinase activity
NicSoilC5_30510	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NicSoilC5_30540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NicSoilC5_30580	COG0306	phosphate transporter
NicSoilC5_30610	COG0739	heme binding
NicSoilC5_30630	COG1609	Transcriptional regulator
NicSoilC5_30660	COG1595	DNA-templated transcription, initiation
NicSoilC5_30710	COG1609	Transcriptional regulator
NicSoilC5_30720	COG1335	isochorismatase
NicSoilC5_30730	COG0831	urea catabolic process
NicSoilC5_30740	COG0832	Belongs to the urease beta subunit family
NicSoilC5_30750	COG0804	urea catabolic process
NicSoilC5_30760	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NicSoilC5_30770	COG0830	nickel cation binding
NicSoilC5_30780	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NicSoilC5_30790	COG0829	nickel cation binding
NicSoilC5_30800	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
NicSoilC5_30850	COG3958	Transketolase
NicSoilC5_30860	COG3959	Transketolase, thiamine diphosphate binding domain
NicSoilC5_30870	COG0477	Major facilitator Superfamily
NicSoilC5_30890	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_30900	COG2376	Dihydroxyacetone kinase
NicSoilC5_30910	COG0698	ribose 5-phosphate isomerase
NicSoilC5_30930	COG2272	Belongs to the type-B carboxylesterase lipase family
NicSoilC5_30960	COG4133	protoheme IX ABC transporter activity
NicSoilC5_31020	COG2723	6-phospho-beta-galactosidase activity
NicSoilC5_31070	COG3250	beta-galactosidase activity
NicSoilC5_31090	COG3507	Belongs to the glycosyl hydrolase 43 family
NicSoilC5_31110	COG0583	DNA-binding transcription factor activity
NicSoilC5_31130	COG1414	Transcriptional regulator
NicSoilC5_31140	COG3250	beta-galactosidase activity
NicSoilC5_31190	COG1175	transmembrane transport
NicSoilC5_31200	COG0395	ABC-type sugar transport system, permease component
NicSoilC5_31210	COG4948	Mandelate Racemase Muconate Lactonizing
NicSoilC5_31220	COG0800	Aldolase
NicSoilC5_31240	COG4948	Mandelate Racemase Muconate Lactonizing
NicSoilC5_31260	COG0477	Major facilitator Superfamily
NicSoilC5_31290	COG2226	methyltransferase
NicSoilC5_31350	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_31370	COG1960	acyl-CoA dehydrogenase activity
NicSoilC5_31390	COG0477	Major facilitator Superfamily
NicSoilC5_31410	COG1609	Transcriptional regulator
NicSoilC5_31420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NicSoilC5_31430	COG2271	Major facilitator Superfamily
NicSoilC5_31440	COG0385	Bile acid
NicSoilC5_31450	COG0243	molybdopterin cofactor binding
NicSoilC5_31480	COG0657	acetylesterase activity
NicSoilC5_31490	COG0179	Fumarylacetoacetate (FAA) hydrolase
NicSoilC5_31500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NicSoilC5_31560	COG0436	Aminotransferase
NicSoilC5_31570	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NicSoilC5_31590	COG0583	DNA-binding transcription factor activity
NicSoilC5_31600	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NicSoilC5_31610	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NicSoilC5_31620	COG1984	allophanate hydrolase subunit 2
NicSoilC5_31630	COG4221	oxidoreductase activity
NicSoilC5_31640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NicSoilC5_31650	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_31660	COG1063	alcohol dehydrogenase
NicSoilC5_31670	COG3265	gluconokinase activity
NicSoilC5_31690	COG0697	spore germination
NicSoilC5_31720	COG0667	Aldo Keto reductase
NicSoilC5_31770	COG2890	protein-(glutamine-N5) methyltransferase activity
NicSoilC5_31780	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NicSoilC5_31860	COG0318	PFAM AMP-dependent synthetase and ligase
NicSoilC5_31870	COG0183	Belongs to the thiolase family
NicSoilC5_31880	COG1960	acyl-CoA dehydrogenase activity
NicSoilC5_31890	COG1309	transcriptional regulator
NicSoilC5_31910	COG0667	Aldo Keto reductase
NicSoilC5_31950	COG3360	Dodecin
NicSoilC5_31960	COG2186	Transcriptional regulator
NicSoilC5_31980	COG2084	Dehydrogenase
NicSoilC5_31990	COG2610	gluconate transmembrane transporter activity
NicSoilC5_32050	COG0300	oxidoreductase activity
NicSoilC5_32070	COG0477	Major facilitator Superfamily
NicSoilC5_32090	COG3285	dna ligase
NicSoilC5_32090	COG1793	dna ligase
NicSoilC5_32100	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NicSoilC5_32140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NicSoilC5_32140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NicSoilC5_32140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NicSoilC5_32150	COG1105	Belongs to the carbohydrate kinase PfkB family
NicSoilC5_32190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NicSoilC5_32210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NicSoilC5_32230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NicSoilC5_32240	COG0509	glycine decarboxylation via glycine cleavage system
NicSoilC5_32250	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NicSoilC5_32260	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NicSoilC5_32260	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NicSoilC5_32270	COG1113	amino acid transport
NicSoilC5_32320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NicSoilC5_32340	COG2733	membrane
NicSoilC5_32360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NicSoilC5_32450	COG4122	O-methyltransferase activity
NicSoilC5_32550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NicSoilC5_32560	COG1191	sigma factor activity
NicSoilC5_32570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NicSoilC5_32580	COG0859	PFAM glycosyl transferase family 9
NicSoilC5_32600	COG0297	glycogen (starch) synthase activity
NicSoilC5_32610	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NicSoilC5_32620	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NicSoilC5_32620	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NicSoilC5_32630	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_32650	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NicSoilC5_32650	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NicSoilC5_32690	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_32710	COG1733	regulation of RNA biosynthetic process
NicSoilC5_32720	COG0702	epimerase
NicSoilC5_32730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NicSoilC5_32740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NicSoilC5_32760	COG1414	Transcriptional regulator
NicSoilC5_32770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NicSoilC5_32820	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NicSoilC5_32860	COG0179	Fumarylacetoacetate (FAA) hydrolase
NicSoilC5_32870	COG0589	response to stress
NicSoilC5_32910	COG3290	protein histidine kinase activity
NicSoilC5_32930	COG0010	Belongs to the arginase family
NicSoilC5_32940	COG3263	regulation of cellular component size
NicSoilC5_32950	COG2252	PERMEase
NicSoilC5_32990	COG3848	Pyruvate phosphate dikinase
NicSoilC5_32990	COG0574	Belongs to the PEP-utilizing enzyme family
NicSoilC5_33030	COG3883	PFAM NLP P60 protein
NicSoilC5_33030	COG0791	NLP P60 protein
NicSoilC5_33090	COG1796	DNA polymerase
NicSoilC5_33090	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NicSoilC5_33160	COG0366	Alpha amylase catalytic
NicSoilC5_33210	COG1609	Transcriptional regulator
NicSoilC5_33240	COG1024	Enoyl-CoA hydratase
NicSoilC5_33280	COG0789	Transcriptional regulator
NicSoilC5_33300	COG1278	Cold shock
NicSoilC5_33310	COG2197	response regulator
NicSoilC5_33320	COG4585	Histidine kinase
NicSoilC5_33340	COG0666	response to abiotic stimulus
NicSoilC5_33370	COG2031	fatty acid transporter
NicSoilC5_33380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NicSoilC5_33400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NicSoilC5_33410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NicSoilC5_33460	COG0357	Ribosomal RNA small subunit methyltransferase G
NicSoilC5_33460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NicSoilC5_33470	COG0191	fructose-bisphosphate aldolase activity
NicSoilC5_33520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NicSoilC5_33550	COG1595	DNA-templated transcription, initiation
NicSoilC5_33570	COG1832	CoA-binding protein
NicSoilC5_33600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NicSoilC5_33610	COG1832	CoA-binding protein
NicSoilC5_33630	COG2315	Protein conserved in bacteria
NicSoilC5_33680	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NicSoilC5_33690	COG0047	phosphoribosylformylglycinamidine synthase activity
NicSoilC5_33720	COG1404	Belongs to the peptidase S8 family
NicSoilC5_33760	COG1846	Transcriptional regulator
NicSoilC5_33800	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NicSoilC5_33830	COG0739	heme binding
NicSoilC5_33830	COG0741	lytic transglycosylase activity
NicSoilC5_33830	COG1196	nuclear chromosome segregation
NicSoilC5_33840	COG0386	Belongs to the glutathione peroxidase family
NicSoilC5_33850	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NicSoilC5_33860	COG0438	transferase activity, transferring glycosyl groups
NicSoilC5_33900	COG1309	transcriptional regulator
NicSoilC5_33920	COG0438	transferase activity, transferring glycosyl groups
NicSoilC5_33950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NicSoilC5_33970	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NicSoilC5_33990	COG1476	TRANSCRIPTIONal
NicSoilC5_34010	COG0642	Histidine kinase
NicSoilC5_34020	COG0745	RESPONSE REGULATOR receiver
NicSoilC5_34030	COG0477	Major facilitator Superfamily
NicSoilC5_34050	COG1309	transcriptional regulator
NicSoilC5_34060	COG0028	Belongs to the TPP enzyme family
NicSoilC5_34070	COG0351	phosphomethylpyrimidine kinase
NicSoilC5_34090	COG0343	queuine tRNA-ribosyltransferase activity
NicSoilC5_34150	COG1621	beta-fructofuranosidase activity
NicSoilC5_34180	COG1960	acyl-CoA dehydrogenase activity
NicSoilC5_34210	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NicSoilC5_34230	COG0586	Pfam SNARE associated Golgi protein
NicSoilC5_34250	COG0564	pseudouridine synthase activity
NicSoilC5_34290	COG2364	Membrane
NicSoilC5_34300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NicSoilC5_34310	COG1201	RNA secondary structure unwinding
NicSoilC5_34320	COG0644	oxidoreductase
NicSoilC5_34370	COG0028	Belongs to the TPP enzyme family
NicSoilC5_34390	COG2066	Belongs to the glutaminase family
NicSoilC5_34400	COG2508	Transcriptional regulator
NicSoilC5_34400	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NicSoilC5_34420	COG0179	Fumarylacetoacetate (FAA) hydrolase
NicSoilC5_34450	COG2814	Major facilitator Superfamily
NicSoilC5_34460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NicSoilC5_34500	COG1309	transcriptional regulator
NicSoilC5_34570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NicSoilC5_34580	COG0657	acetylesterase activity
NicSoilC5_34590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NicSoilC5_34610	COG1609	Transcriptional regulator
NicSoilC5_34630	COG1175	transmembrane transport
NicSoilC5_34640	COG0395	ABC-type sugar transport system, permease component
NicSoilC5_34660	COG0673	inositol 2-dehydrogenase activity
NicSoilC5_34680	COG1904	glucuronate isomerase
NicSoilC5_34690	COG0246	Mannitol dehydrogenase
NicSoilC5_34700	COG4948	Mandelate Racemase Muconate Lactonizing
NicSoilC5_34800	COG0438	transferase activity, transferring glycosyl groups
NicSoilC5_34820	COG0671	phosphoesterase, PA-phosphatase related
NicSoilC5_34830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NicSoilC5_34860	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NicSoilC5_34870	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NicSoilC5_34870	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NicSoilC5_34890	COG2205	protein histidine kinase activity
NicSoilC5_34900	COG0745	RESPONSE REGULATOR receiver
NicSoilC5_34930	COG2062	phosphohistidine phosphatase, SixA
NicSoilC5_34940	COG0583	DNA-binding transcription factor activity
NicSoilC5_34960	COG1309	transcriptional regulator
NicSoilC5_34970	COG1511	domain protein
NicSoilC5_35000	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
NicSoilC5_35010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NicSoilC5_35010	COG1017	nitric oxide dioxygenase activity
NicSoilC5_35040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NicSoilC5_35050	COG0514	ATP-dependent DNA helicase (RecQ)
NicSoilC5_35080	COG1505	serine-type exopeptidase activity
NicSoilC5_35100	COG0737	Belongs to the 5'-nucleotidase family
NicSoilC5_35110	COG0604	alcohol dehydrogenase
NicSoilC5_35110	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_35110	COG3321	synthase
NicSoilC5_35130	COG0577	efflux transmembrane transporter activity
NicSoilC5_35130	COG1136	(ABC) transporter
NicSoilC5_35150	COG1966	Carbon starvation protein
NicSoilC5_35190	COG0656	L-ascorbic acid biosynthetic process
NicSoilC5_35230	COG1252	NADH dehydrogenase
NicSoilC5_35300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NicSoilC5_35310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NicSoilC5_35350	COG0588	phosphoglycerate mutase activity
NicSoilC5_35370	COG5002	protein histidine kinase activity
NicSoilC5_35430	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NicSoilC5_35440	COG0215	cysteine-tRNA ligase activity
NicSoilC5_35500	COG0366	Alpha amylase catalytic
NicSoilC5_35520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NicSoilC5_35540	COG1609	Transcriptional regulator
NicSoilC5_35550	COG0366	Alpha amylase catalytic
NicSoilC5_35560	COG0277	FAD linked oxidase domain protein
NicSoilC5_35580	COG3842	ATPase activity
NicSoilC5_35600	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NicSoilC5_35650	COG4214	carbohydrate transport
NicSoilC5_35660	COG1129	ABC transporter
NicSoilC5_35670	COG4213	ABC transporter substrate-binding protein
NicSoilC5_35700	COG2160	L-arabinose isomerase activity
NicSoilC5_35710	COG1609	Transcriptional regulator
NicSoilC5_35760	COG0783	Belongs to the Dps family
NicSoilC5_35770	COG0477	Major facilitator Superfamily
NicSoilC5_35790	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NicSoilC5_35790	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NicSoilC5_35800	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NicSoilC5_35820	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
NicSoilC5_35870	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NicSoilC5_35900	COG1278	Cold shock
NicSoilC5_35920	COG0459	protein refolding
NicSoilC5_35930	COG1653	transport
NicSoilC5_35940	COG0328	RNA-DNA hybrid ribonuclease activity
NicSoilC5_35960	COG2205	protein histidine kinase activity
NicSoilC5_35970	COG0745	RESPONSE REGULATOR receiver
NicSoilC5_36010	COG1061	Type III restriction enzyme res subunit
NicSoilC5_36040	COG1278	Cold shock
NicSoilC5_36080	COG0739	heme binding
NicSoilC5_36090	COG0791	NLP P60 protein
NicSoilC5_36090	COG1388	LysM domain
NicSoilC5_36090	COG3103	Sh3 type 3 domain protein
NicSoilC5_36120	COG0746	molybdenum cofactor guanylyltransferase activity
NicSoilC5_36150	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NicSoilC5_36190	COG0488	(ABC) transporter
NicSoilC5_36200	COG1132	(ABC) transporter
NicSoilC5_36210	COG0494	nUDIX hydrolase
NicSoilC5_36250	COG0483	inositol monophosphate 1-phosphatase activity
NicSoilC5_36280	COG0045	succinate-CoA ligase (ADP-forming) activity
NicSoilC5_36320	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_36340	COG1082	Xylose isomerase domain protein TIM barrel
NicSoilC5_36350	COG2376	Dihydroxyacetone kinase
NicSoilC5_36360	COG0698	ribose 5-phosphate isomerase
NicSoilC5_36370	COG1250	3-hydroxyacyl-CoA dehydrogenase
NicSoilC5_36380	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_36390	COG2271	Major facilitator Superfamily
NicSoilC5_36400	COG0149	triose-phosphate isomerase activity
NicSoilC5_36420	COG0640	Transcriptional regulator
NicSoilC5_36430	COG1942	4-Oxalocrotonate Tautomerase
NicSoilC5_36460	COG3962	Belongs to the TPP enzyme family
NicSoilC5_36490	COG0673	inositol 2-dehydrogenase activity
NicSoilC5_36500	COG1082	Xylose isomerase domain protein TIM barrel
NicSoilC5_36510	COG2814	Major facilitator Superfamily
NicSoilC5_36530	COG2814	Major facilitator Superfamily
NicSoilC5_36540	COG1609	Transcriptional regulator
NicSoilC5_36550	COG3718	enzyme involved in inositol metabolism
NicSoilC5_36560	COG2188	Transcriptional regulator
NicSoilC5_36570	COG2814	Major facilitator Superfamily
NicSoilC5_36620	COG1396	sequence-specific DNA binding
NicSoilC5_36640	COG0028	Belongs to the TPP enzyme family
NicSoilC5_36660	COG0477	Major facilitator Superfamily
NicSoilC5_36710	COG1401	restriction endodeoxyribonuclease activity
NicSoilC5_36730	COG5002	protein histidine kinase activity
NicSoilC5_36740	COG0745	RESPONSE REGULATOR receiver
NicSoilC5_36770	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NicSoilC5_36770	COG4124	Belongs to the glycosyl hydrolase 26 family
NicSoilC5_36830	COG1902	pentaerythritol trinitrate reductase activity
NicSoilC5_36850	COG2183	response to ionizing radiation
NicSoilC5_36910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NicSoilC5_36940	COG3583	domain protein
NicSoilC5_36950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NicSoilC5_36960	COG3103	Sh3 type 3 domain protein
NicSoilC5_36960	COG0366	Alpha amylase catalytic
NicSoilC5_36970	COG1254	Belongs to the acylphosphatase family
NicSoilC5_37000	COG0477	Major facilitator Superfamily
NicSoilC5_37010	COG1063	alcohol dehydrogenase
NicSoilC5_37040	COG0246	Mannitol dehydrogenase
NicSoilC5_37050	COG0800	Aldolase
NicSoilC5_37080	COG0667	Aldo Keto reductase
NicSoilC5_37090	COG1063	alcohol dehydrogenase
NicSoilC5_37120	COG0477	Major facilitator Superfamily
NicSoilC5_37130	COG0412	Dienelactone hydrolase
NicSoilC5_37150	COG1253	flavin adenine dinucleotide binding
NicSoilC5_37170	COG0179	Fumarylacetoacetate (FAA) hydrolase
NicSoilC5_37210	COG4948	Mandelate Racemase Muconate Lactonizing
NicSoilC5_37220	COG2186	Transcriptional regulator
NicSoilC5_37240	COG1175	transmembrane transport
NicSoilC5_37250	COG0395	ABC-type sugar transport system, permease component
NicSoilC5_37270	COG0640	Transcriptional regulator
NicSoilC5_37340	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilC5_37350	COG0395	ABC-type sugar transport system, permease component
NicSoilC5_37360	COG1175	transmembrane transport
NicSoilC5_37380	COG3684	Belongs to the aldolase LacD family
NicSoilC5_37400	COG0673	inositol 2-dehydrogenase activity
NicSoilC5_37480	COG0477	Major facilitator Superfamily
NicSoilC5_37490	COG1846	Transcriptional regulator
NicSoilC5_37550	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NicSoilC5_37560	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NicSoilC5_37570	COG4770	biotin carboxylase activity
NicSoilC5_37670	COG0277	FAD linked oxidase domain protein
NicSoilC5_37680	COG2186	Transcriptional regulator
NicSoilC5_37690	COG1620	l-lactate permease
NicSoilC5_37700	COG0247	lactate metabolic process
NicSoilC5_37710	COG1139	Iron-sulfur cluster binding protein
NicSoilC5_37720	COG1556	Lactate utilization protein
NicSoilC5_37840	COG1609	Transcriptional regulator
NicSoilC5_37890	COG3573	Dehydrogenase
NicSoilC5_37960	COG3415	Transposase
NicSoilC5_37960	COG2801	Transposase and inactivated derivatives
NicSoilC5_37970	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NicSoilC5_38050	COG3848	Pyruvate phosphate dikinase
NicSoilC5_38050	COG0574	Belongs to the PEP-utilizing enzyme family
NicSoilC5_38090	COG3848	Pyruvate phosphate dikinase
NicSoilC5_38090	COG0574	Belongs to the PEP-utilizing enzyme family
NicSoilC5_38120	COG1984	allophanate hydrolase subunit 2
NicSoilC5_38130	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NicSoilC5_38140	COG0439	Biotin carboxylase
NicSoilC5_38150	COG0511	ligase activity, forming carbon-carbon bonds
NicSoilC5_38160	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NicSoilC5_38170	COG2508	Transcriptional regulator
NicSoilC5_38190	COG0252	asparaginase activity
NicSoilC5_38220	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_38230	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_38310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NicSoilC5_38320	COG0531	amino acid
NicSoilC5_38330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NicSoilC5_38370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NicSoilC5_38390	COG1201	RNA secondary structure unwinding
NicSoilC5_38400	COG0210	DNA helicase
NicSoilC5_38440	COG1609	Transcriptional regulator
NicSoilC5_38480	COG1172	Belongs to the binding-protein-dependent transport system permease family
NicSoilC5_38490	COG0673	inositol 2-dehydrogenase activity
NicSoilC5_38540	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NicSoilC5_38570	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_38580	COG1053	succinate dehydrogenase
NicSoilC5_38590	COG1063	alcohol dehydrogenase
NicSoilC5_38610	COG0583	DNA-binding transcription factor activity
NicSoilC5_38620	COG0583	DNA-binding transcription factor activity
NicSoilC5_38630	COG0477	Major facilitator Superfamily
NicSoilC5_38640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NicSoilC5_38650	COG0673	inositol 2-dehydrogenase activity
NicSoilC5_38690	COG1053	succinate dehydrogenase
NicSoilC5_38710	COG2350	Protein conserved in bacteria
NicSoilC5_38720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NicSoilC5_38730	COG0477	Major facilitator Superfamily
NicSoilC5_38760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NicSoilC5_38770	COG1349	DNA-binding transcription factor activity
NicSoilC5_38780	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NicSoilC5_38790	COG3395	kinase activity
NicSoilC5_38820	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NicSoilC5_38830	COG2814	Major facilitator Superfamily
NicSoilC5_38880	COG3540	Alkaline phosphatase
NicSoilC5_38920	COG2072	flavoprotein involved in K transport
NicSoilC5_38930	COG1063	alcohol dehydrogenase
NicSoilC5_39080	COG1914	H( )-stimulated, divalent metal cation uptake system
NicSoilC5_39110	COG1278	Cold shock
NicSoilC5_39140	COG3265	gluconokinase activity
NicSoilC5_39150	COG2610	gluconate transmembrane transporter activity
NicSoilC5_39220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NicSoilC5_39260	COG0833	amino acid
NicSoilC5_39280	COG1414	Transcriptional regulator
NicSoilC5_39290	COG2040	homocysteine
NicSoilC5_39330	COG5001	Diguanylate cyclase
NicSoilC5_39330	COG3300	MHYT domain
NicSoilC5_39350	COG0561	phosphatase activity
NicSoilC5_39360	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NicSoilC5_39370	COG0438	transferase activity, transferring glycosyl groups
NicSoilC5_39370	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NicSoilC5_39380	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
NicSoilC5_39430	COG0477	Major facilitator Superfamily
NicSoilC5_39440	COG0138	bifunctional purine biosynthesis protein purh
NicSoilC5_39470	COG2838	Isocitrate dehydrogenase
NicSoilC5_39490	COG0515	serine threonine protein kinase
NicSoilC5_39530	COG1136	(ABC) transporter
NicSoilC5_39550	COG4213	ABC transporter substrate-binding protein
NicSoilC5_39560	COG4214	carbohydrate transport
NicSoilC5_39610	COG0531	amino acid
NicSoilC5_39650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NicSoilC5_39660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NicSoilC5_39670	COG4585	Histidine kinase
NicSoilC5_39680	COG2197	response regulator
NicSoilC5_39710	COG0708	Exodeoxyribonuclease III
NicSoilC5_39720	COG0180	Tryptophanyl-tRNA synthetase
NicSoilC5_39800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NicSoilC5_39830	COG2009	succinate dehydrogenase
NicSoilC5_39850	COG1473	amidohydrolase
NicSoilC5_39850	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NicSoilC5_39860	COG1846	Transcriptional regulator
NicSoilC5_39870	COG1764	response to oxidative stress
NicSoilC5_39880	COG2130	NADP-dependent
NicSoilC5_39900	COG1744	ABC transporter substrate-binding protein PnrA-like
NicSoilC5_39910	COG3845	ABC transporter
NicSoilC5_39920	COG4603	Belongs to the binding-protein-dependent transport system permease family
NicSoilC5_39930	COG1079	Belongs to the binding-protein-dependent transport system permease family
NicSoilC5_39960	COG0586	Pfam SNARE associated Golgi protein
NicSoilC5_39970	COG0586	Pfam SNARE associated Golgi protein
NicSoilC5_39980	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NicSoilC5_39990	COG3956	TIGRFAM MazG family protein
NicSoilC5_40000	COG0148	phosphopyruvate hydratase activity
NicSoilC5_40050	COG1252	NADH dehydrogenase
NicSoilC5_40120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NicSoilC5_40140	COG2017	converts alpha-aldose to the beta-anomer
NicSoilC5_40160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NicSoilC5_40180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NicSoilC5_40200	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NicSoilC5_40230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NicSoilC5_40240	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NicSoilC5_40310	COG0114	fumarate hydratase activity
NicSoilC5_40320	COG0288	reversible hydration of carbon dioxide
NicSoilC5_40340	COG1494	fructose-1,6-bisphosphatase
NicSoilC5_40360	COG1482	cell wall glycoprotein biosynthetic process
NicSoilC5_40370	COG1316	TRANSCRIPTIONal
NicSoilC5_40390	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NicSoilC5_40480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NicSoilC5_40600	COG0714	Associated with various cellular activities
NicSoilC5_40610	COG0084	hydrolase, TatD family'
NicSoilC5_40620	COG3583	domain protein
NicSoilC5_40630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NicSoilC5_40640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NicSoilC5_40650	COG0488	(ABC) transporter
NicSoilC5_40660	COG1309	transcriptional regulator
NicSoilC5_40670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NicSoilC5_40690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NicSoilC5_40700	COG0193	aminoacyl-tRNA hydrolase activity
NicSoilC5_40740	COG0822	iron-sulfur transferase activity
NicSoilC5_40770	COG0702	epimerase
NicSoilC5_40810	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NicSoilC5_40820	COG0446	pyridine nucleotide-disulphide oxidoreductase
NicSoilC5_40850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NicSoilC5_40870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NicSoilC5_40930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NicSoilC5_40940	COG0243	molybdopterin cofactor binding
NicSoilC5_40950	COG2223	nitrite transmembrane transporter activity
NicSoilC5_40960	COG0477	Major facilitator Superfamily
NicSoilC5_40990	COG4770	biotin carboxylase activity
NicSoilC5_41000	COG0424	maF-like protein
NicSoilC5_41010	COG2409	Drug exporters of the RND superfamily
NicSoilC5_41040	COG1823	symporter activity
NicSoilC5_41050	COG0671	phosphoesterase, PA-phosphatase related
NicSoilC5_41080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NicSoilC5_41090	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilC5_41100	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NicSoilC5_41100	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NicSoilC5_41150	COG0714	Associated with various cellular activities
NicSoilC5_41190	COG0631	protein serine/threonine phosphatase activity
NicSoilC5_41230	COG1674	ftsk spoiiie
NicSoilC5_41250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NicSoilC5_41260	COG0483	inositol monophosphate 1-phosphatase activity
NicSoilC5_41280	COG0251	oxidation-reduction process
NicSoilC5_41290	COG4565	transcriptional regulatory protein
NicSoilC5_41310	COG2851	Citrate transporter
NicSoilC5_41320	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NicSoilC5_41330	COG0154	amidase activity
NicSoilC5_41340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NicSoilC5_41360	COG0583	DNA-binding transcription factor activity
NicSoilC5_41370	COG1063	alcohol dehydrogenase
NicSoilC5_41380	COG0156	8-amino-7-oxononanoate synthase activity
NicSoilC5_41400	COG1228	amidohydrolase
NicSoilC5_41460	COG2873	o-acetylhomoserine
NicSoilC5_41470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NicSoilC5_41550	COG0400	carboxylic ester hydrolase activity
NicSoilC5_41580	COG0423	glycine-tRNA ligase activity
NicSoilC5_41610	COG2267	carboxylic ester hydrolase activity
NicSoilC5_41630	COG1017	nitric oxide dioxygenase activity
NicSoilC5_41630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NicSoilC5_41710	COG0358	DNA primase activity
NicSoilC5_41740	COG2814	Major facilitator Superfamily
NicSoilC5_41790	COG1960	acyl-CoA dehydrogenase activity
NicSoilC5_41810	COG0052	Belongs to the universal ribosomal protein uS2 family
NicSoilC5_41820	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NicSoilC5_41830	COG0528	UMP kinase activity
NicSoilC5_41840	COG0233	cytoplasmic translational termination
NicSoilC5_41880	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NicSoilC5_41900	COG3279	Response regulator of the LytR AlgR family
NicSoilC5_41910	COG3275	phosphorelay sensor kinase activity
NicSoilC5_41930	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NicSoilC5_41970	COG1522	sequence-specific DNA binding
NicSoilC5_41990	COG0022	dehydrogenase e1 component
NicSoilC5_42000	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilC5_42020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NicSoilC5_42040	COG1960	acyl-CoA dehydrogenase activity
NicSoilC5_42100	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NicSoilC5_42110	COG0750	zinc metalloprotease
NicSoilC5_42160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NicSoilC5_42190	COG0442	prolyl-tRNA aminoacylation
NicSoilC5_42220	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
NicSoilC5_42250	COG0779	Required for maturation of 30S ribosomal subunits
NicSoilC5_42260	COG0195	Participates in both transcription termination and antitermination
NicSoilC5_42280	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NicSoilC5_42290	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NicSoilC5_42310	COG0590	tRNA wobble adenosine to inosine editing
NicSoilC5_42330	COG0436	Aminotransferase
NicSoilC5_42340	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NicSoilC5_42380	COG3483	tryptophan 2,3-dioxygenase activity
NicSoilC5_42400	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NicSoilC5_42410	COG1185	polyribonucleotide nucleotidyltransferase activity
NicSoilC5_42420	COG0612	Peptidase, M16
NicSoilC5_42530	COG0521	Mo-molybdopterin cofactor biosynthetic process
NicSoilC5_42550	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NicSoilC5_42600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NicSoilC5_42610	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NicSoilC5_42620	COG1674	ftsk spoiiie
NicSoilC5_42640	COG1546	Belongs to the CinA family
NicSoilC5_42640	COG1058	Belongs to the CinA family
NicSoilC5_42660	COG1396	sequence-specific DNA binding
NicSoilC5_42690	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NicSoilC5_42700	COG2137	regulation of response to DNA damage stimulus
NicSoilC5_42710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NicSoilC5_42720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NicSoilC5_42730	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NicSoilC5_42740	COG2813	Specifically methylates the guanine in position
NicSoilC5_42750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NicSoilC5_42770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NicSoilC5_42790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NicSoilC5_42800	COG0131	Imidazoleglycerol-phosphate dehydratase
NicSoilC5_42810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NicSoilC5_42830	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NicSoilC5_42880	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NicSoilC5_42890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NicSoilC5_42900	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NicSoilC5_42930	COG2814	Major facilitator Superfamily
NicSoilC5_42950	COG0494	nUDIX hydrolase
NicSoilC5_42990	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NicSoilC5_43000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NicSoilC5_43000	COG0072	phenylalanine-tRNA ligase activity
NicSoilC5_43050	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NicSoilC5_43060	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NicSoilC5_43070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NicSoilC5_43080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NicSoilC5_43090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NicSoilC5_43100	COG1438	arginine binding
NicSoilC5_43110	COG0137	argininosuccinate synthase activity
NicSoilC5_43120	COG0165	Argininosuccinate lyase
NicSoilC5_43130	COG0259	pyridoxamine-phosphate oxidase activity
NicSoilC5_43170	COG2094	Belongs to the DNA glycosylase MPG family
NicSoilC5_43180	COG3973	AAA domain
NicSoilC5_43190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NicSoilC5_43210	COG0647	UMP catabolic process
NicSoilC5_43240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NicSoilC5_43250	COG0497	DNA recombination
NicSoilC5_43260	COG0504	CTP synthase activity
NicSoilC5_43270	COG0494	nUDIX hydrolase
NicSoilC5_43330	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NicSoilC5_43340	COG2079	MmgE PrpD family protein
NicSoilC5_43380	COG3290	protein histidine kinase activity
NicSoilC5_43410	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NicSoilC5_43420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NicSoilC5_43450	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily