locus-tag	class	description
NicSoilE8_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NicSoilE8_00020	COG0592	DNA-directed DNA polymerase activity
NicSoilE8_00030	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NicSoilE8_00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NicSoilE8_00050	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
NicSoilE8_00060	COG0187	DNA topoisomerase II activity
NicSoilE8_00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NicSoilE8_00090	COG3266	domain, Protein
NicSoilE8_00100	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NicSoilE8_00100	COG3291	Pkd domain containing protein
NicSoilE8_00120	COG1215	transferase activity, transferring glycosyl groups
NicSoilE8_00150	COG0457	Tetratricopeptide repeat
NicSoilE8_00150	COG0705	Rhomboid family
NicSoilE8_00170	COG2818	Glycosylase
NicSoilE8_00190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NicSoilE8_00190	COG2169	Transcriptional regulator
NicSoilE8_00200	COG1595	DNA-templated transcription, initiation
NicSoilE8_00230	COG3764	Sortase (surface protein transpeptidase)
NicSoilE8_00250	COG0515	serine threonine protein kinase
NicSoilE8_00260	COG0515	serine threonine protein kinase
NicSoilE8_00270	COG0768	penicillin binding
NicSoilE8_00300	COG1716	ATPase activity
NicSoilE8_00310	COG1716	ATPase activity
NicSoilE8_00410	COG0346	lactoylglutathione lyase activity
NicSoilE8_00440	COG2186	Transcriptional regulator
NicSoilE8_00450	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NicSoilE8_00460	COG0477	Major facilitator Superfamily
NicSoilE8_00470	COG1984	allophanate hydrolase subunit 2
NicSoilE8_00480	COG4770	biotin carboxylase activity
NicSoilE8_00490	COG0277	FAD linked oxidase domain protein
NicSoilE8_00500	COG0659	secondary active sulfate transmembrane transporter activity
NicSoilE8_00540	COG0435	Glutathione S-transferase
NicSoilE8_00550	COG0561	phosphatase activity
NicSoilE8_00570	COG0584	glycerophosphoryl diester phosphodiesterase
NicSoilE8_00580	COG3250	beta-galactosidase activity
NicSoilE8_00590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NicSoilE8_00600	COG1929	Belongs to the glycerate kinase type-1 family
NicSoilE8_00630	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NicSoilE8_00650	COG0693	protein deglycase activity
NicSoilE8_00670	COG3655	Transcriptional regulator
NicSoilE8_00690	COG2233	PERMEase
NicSoilE8_00700	COG0778	Nitroreductase
NicSoilE8_00730	COG3104	oligopeptide transport
NicSoilE8_00750	COG3340	Belongs to the peptidase S51 family
NicSoilE8_00760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NicSoilE8_00760	COG0425	Belongs to the sulfur carrier protein TusA family
NicSoilE8_00770	COG0077	Prephenate dehydratase
NicSoilE8_00790	COG1597	lipid kinase activity
NicSoilE8_00800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NicSoilE8_00810	COG0561	phosphatase activity
NicSoilE8_00850	COG1191	sigma factor activity
NicSoilE8_00860	COG0859	PFAM glycosyl transferase family 9
NicSoilE8_00870	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NicSoilE8_00880	COG0859	PFAM glycosyl transferase family 9
NicSoilE8_00900	COG0438	transferase activity, transferring glycosyl groups
NicSoilE8_00910	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NicSoilE8_00920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NicSoilE8_00920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NicSoilE8_00950	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NicSoilE8_00950	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NicSoilE8_01060	COG2027	D-alanyl-D-alanine carboxypeptidase
NicSoilE8_01080	COG0037	tRNA processing
NicSoilE8_01110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NicSoilE8_01120	COG0302	gtp cyclohydrolase
NicSoilE8_01140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NicSoilE8_01200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NicSoilE8_01210	COG2814	Major facilitator Superfamily
NicSoilE8_01250	COG0477	Major facilitator Superfamily
NicSoilE8_01300	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NicSoilE8_01340	COG1819	glycosyl
NicSoilE8_01350	COG1506	peptidase
NicSoilE8_01350	COG0823	Involved in the tonB-independent uptake of proteins
NicSoilE8_01360	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NicSoilE8_01390	COG2376	Dihydroxyacetone kinase
NicSoilE8_01400	COG1461	Dihydroxyacetone kinase
NicSoilE8_01410	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
NicSoilE8_01420	COG3237	CsbD-like
NicSoilE8_01450	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_01530	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NicSoilE8_01540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NicSoilE8_01550	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NicSoilE8_01560	COG3559	Exporter of polyketide antibiotics
NicSoilE8_01650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NicSoilE8_01660	COG0492	ferredoxin-NADP+ reductase activity
NicSoilE8_01680	COG0671	phosphoesterase, PA-phosphatase related
NicSoilE8_01730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NicSoilE8_01820	COG0831	urea catabolic process
NicSoilE8_01830	COG0832	Belongs to the urease beta subunit family
NicSoilE8_01840	COG0804	urea catabolic process
NicSoilE8_01850	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NicSoilE8_01860	COG0830	nickel cation binding
NicSoilE8_01870	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NicSoilE8_01880	COG0829	nickel cation binding
NicSoilE8_01890	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
NicSoilE8_01900	COG1595	DNA-templated transcription, initiation
NicSoilE8_01940	COG2706	6-phosphogluconolactonase activity
NicSoilE8_01950	COG0656	L-ascorbic acid biosynthetic process
NicSoilE8_01970	COG0667	Aldo Keto reductase
NicSoilE8_02000	COG3360	Dodecin
NicSoilE8_02010	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_02030	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NicSoilE8_02050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NicSoilE8_02110	COG2186	Transcriptional regulator
NicSoilE8_02140	COG2084	Dehydrogenase
NicSoilE8_02150	COG2610	gluconate transmembrane transporter activity
NicSoilE8_02260	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NicSoilE8_02330	COG0697	spore germination
NicSoilE8_02340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NicSoilE8_02350	COG2186	Transcriptional regulator
NicSoilE8_02370	COG1175	transmembrane transport
NicSoilE8_02390	COG4948	Mandelate Racemase Muconate Lactonizing
NicSoilE8_02420	COG0477	Major facilitator Superfamily
NicSoilE8_02430	COG2890	protein-(glutamine-N5) methyltransferase activity
NicSoilE8_02470	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NicSoilE8_02550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NicSoilE8_02550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NicSoilE8_02550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NicSoilE8_02570	COG1349	DNA-binding transcription factor activity
NicSoilE8_02620	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NicSoilE8_02680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NicSoilE8_02740	COG1846	Transcriptional regulator
NicSoilE8_02790	COG0142	geranyltranstransferase activity
NicSoilE8_02800	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NicSoilE8_02890	COG1609	Transcriptional regulator
NicSoilE8_02900	COG1609	Transcriptional regulator
NicSoilE8_02930	COG0277	FAD linked oxidase domain protein
NicSoilE8_02950	COG4172	Belongs to the ABC transporter superfamily
NicSoilE8_02960	COG0444	Belongs to the ABC transporter superfamily
NicSoilE8_02980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NicSoilE8_03040	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_03050	COG3250	beta-galactosidase activity
NicSoilE8_03060	COG1609	Transcriptional regulator
NicSoilE8_03070	COG1904	glucuronate isomerase
NicSoilE8_03080	COG0246	Mannitol dehydrogenase
NicSoilE8_03090	COG4948	Mandelate Racemase Muconate Lactonizing
NicSoilE8_03100	COG3265	gluconokinase activity
NicSoilE8_03110	COG2084	Dehydrogenase
NicSoilE8_03200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NicSoilE8_03210	COG0028	Belongs to the TPP enzyme family
NicSoilE8_03230	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_03240	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_03260	COG3622	Belongs to the hyi family
NicSoilE8_03270	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_03290	COG2828	Protein conserved in bacteria
NicSoilE8_03340	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NicSoilE8_03350	COG1984	allophanate hydrolase subunit 2
NicSoilE8_03360	COG2733	membrane
NicSoilE8_03440	COG4122	O-methyltransferase activity
NicSoilE8_03490	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_03530	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NicSoilE8_03570	COG2902	Dehydrogenase
NicSoilE8_03590	COG0010	Belongs to the arginase family
NicSoilE8_03600	COG2252	PERMEase
NicSoilE8_03650	COG0574	Belongs to the PEP-utilizing enzyme family
NicSoilE8_03650	COG3848	Pyruvate phosphate dikinase
NicSoilE8_03680	COG1609	Transcriptional regulator
NicSoilE8_03730	COG1802	Transcriptional regulator
NicSoilE8_03750	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_03760	COG1175	transmembrane transport
NicSoilE8_03770	COG1285	pathogenesis
NicSoilE8_03900	COG2182	Extracellular solute-binding protein
NicSoilE8_03940	COG1609	Transcriptional regulator
NicSoilE8_03980	COG2197	response regulator
NicSoilE8_03990	COG4585	Histidine kinase
NicSoilE8_04010	COG0666	response to abiotic stimulus
NicSoilE8_04030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NicSoilE8_04050	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NicSoilE8_04100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NicSoilE8_04120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NicSoilE8_04130	COG0303	'Molybdopterin
NicSoilE8_04140	COG1063	alcohol dehydrogenase
NicSoilE8_04160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NicSoilE8_04170	COG3404	Formiminotransferase-cyclodeaminase
NicSoilE8_04200	COG1802	Transcriptional regulator
NicSoilE8_04210	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NicSoilE8_04220	COG0583	DNA-binding transcription factor activity
NicSoilE8_04270	COG0415	Belongs to the DNA photolyase family
NicSoilE8_04290	COG1024	Enoyl-CoA hydratase
NicSoilE8_04360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NicSoilE8_04370	COG1960	acyl-CoA dehydrogenase activity
NicSoilE8_04390	COG3328	transposase activity
NicSoilE8_04410	COG2801	Transposase and inactivated derivatives
NicSoilE8_04440	COG0789	Transcriptional regulator
NicSoilE8_04470	COG1609	Transcriptional regulator
NicSoilE8_04500	COG0747	negative chemotaxis
NicSoilE8_04520	COG0444	Belongs to the ABC transporter superfamily
NicSoilE8_04550	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_04560	COG1609	Transcriptional regulator
NicSoilE8_04570	COG1904	glucuronate isomerase
NicSoilE8_04580	COG0246	Mannitol dehydrogenase
NicSoilE8_04600	COG4948	Mandelate Racemase Muconate Lactonizing
NicSoilE8_04620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NicSoilE8_04690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NicSoilE8_04690	COG0357	Ribosomal RNA small subunit methyltransferase G
NicSoilE8_04740	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NicSoilE8_04760	COG0477	Major facilitator Superfamily
NicSoilE8_04780	COG1846	Transcriptional regulator
NicSoilE8_04820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NicSoilE8_04830	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_04840	COG1126	abc transporter atp-binding protein
NicSoilE8_04850	COG0765	amino acid transport
NicSoilE8_04870	COG1609	Transcriptional regulator
NicSoilE8_04880	COG0477	Major facilitator Superfamily
NicSoilE8_04930	COG2271	Major facilitator Superfamily
NicSoilE8_04950	COG0129	dihydroxy-acid dehydratase activity
NicSoilE8_04960	COG0604	alcohol dehydrogenase
NicSoilE8_04960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NicSoilE8_04960	COG3321	synthase
NicSoilE8_04960	COG4221	oxidoreductase activity
NicSoilE8_04980	COG1621	beta-fructofuranosidase activity
NicSoilE8_05020	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NicSoilE8_05170	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NicSoilE8_05250	COG0667	Aldo Keto reductase
NicSoilE8_05260	COG1501	Belongs to the glycosyl hydrolase 31 family
NicSoilE8_05270	COG3387	PFAM Glycoside hydrolase 15-related
NicSoilE8_05290	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_05300	COG1175	transmembrane transport
NicSoilE8_05310	COG1846	Transcriptional regulator
NicSoilE8_05310	COG1940	carbohydrate kinase activity
NicSoilE8_05320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NicSoilE8_05380	COG1175	transmembrane transport
NicSoilE8_05390	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_05400	COG1609	Transcriptional regulator
NicSoilE8_05450	COG1832	CoA-binding protein
NicSoilE8_05480	COG2315	Protein conserved in bacteria
NicSoilE8_05490	COG1653	transport
NicSoilE8_05500	COG1175	transmembrane transport
NicSoilE8_05510	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_05540	COG3706	GGDEF domain
NicSoilE8_05570	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NicSoilE8_05580	COG0047	phosphoribosylformylglycinamidine synthase activity
NicSoilE8_05620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NicSoilE8_05640	COG1404	Belongs to the peptidase S8 family
NicSoilE8_05700	COG1846	Transcriptional regulator
NicSoilE8_05790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NicSoilE8_05810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NicSoilE8_05830	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilE8_05870	COG0741	lytic transglycosylase activity
NicSoilE8_05870	COG0739	heme binding
NicSoilE8_05870	COG1196	nuclear chromosome segregation
NicSoilE8_05930	COG1309	transcriptional regulator
NicSoilE8_05940	COG1609	Transcriptional regulator
NicSoilE8_05960	COG1175	transmembrane transport
NicSoilE8_05970	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_06000	COG0438	transferase activity, transferring glycosyl groups
NicSoilE8_06030	COG0589	response to stress
NicSoilE8_06070	COG3290	protein histidine kinase activity
NicSoilE8_06080	COG4565	transcriptional regulatory protein
NicSoilE8_06100	COG2855	membrane
NicSoilE8_06150	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_06160	COG1175	transmembrane transport
NicSoilE8_06170	COG2182	Extracellular solute-binding protein
NicSoilE8_06180	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_06220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NicSoilE8_06240	COG1476	TRANSCRIPTIONal
NicSoilE8_06250	COG1309	transcriptional regulator
NicSoilE8_06270	COG0351	phosphomethylpyrimidine kinase
NicSoilE8_06290	COG0642	Histidine kinase
NicSoilE8_06300	COG0745	RESPONSE REGULATOR receiver
NicSoilE8_06310	COG0477	Major facilitator Superfamily
NicSoilE8_06340	COG1090	epimerase
NicSoilE8_06350	COG1309	transcriptional regulator
NicSoilE8_06410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NicSoilE8_06430	COG0477	Major facilitator Superfamily
NicSoilE8_06440	COG2508	Transcriptional regulator
NicSoilE8_06450	COG0477	Major facilitator Superfamily
NicSoilE8_06460	COG0028	Belongs to the TPP enzyme family
NicSoilE8_06470	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilE8_06480	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NicSoilE8_06490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NicSoilE8_06520	COG3842	ATPase activity
NicSoilE8_06570	COG1960	acyl-CoA dehydrogenase activity
NicSoilE8_06620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NicSoilE8_06670	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NicSoilE8_06690	COG0586	Pfam SNARE associated Golgi protein
NicSoilE8_06710	COG0564	pseudouridine synthase activity
NicSoilE8_06740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NicSoilE8_06750	COG2364	Membrane
NicSoilE8_06760	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NicSoilE8_06770	COG1201	RNA secondary structure unwinding
NicSoilE8_06880	COG0438	transferase activity, transferring glycosyl groups
NicSoilE8_06900	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NicSoilE8_06960	COG2062	phosphohistidine phosphatase, SixA
NicSoilE8_06970	COG0583	DNA-binding transcription factor activity
NicSoilE8_06980	COG0697	spore germination
NicSoilE8_07000	COG1309	transcriptional regulator
NicSoilE8_07010	COG1511	domain protein
NicSoilE8_07020	COG1129	ABC transporter
NicSoilE8_07040	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
NicSoilE8_07050	COG1940	carbohydrate kinase activity
NicSoilE8_07060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NicSoilE8_07070	COG4608	Belongs to the ABC transporter superfamily
NicSoilE8_07080	COG0444	Belongs to the ABC transporter superfamily
NicSoilE8_07090	COG0601	transmembrane transport
NicSoilE8_07100	COG0747	negative chemotaxis
NicSoilE8_07120	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
NicSoilE8_07130	COG1017	nitric oxide dioxygenase activity
NicSoilE8_07130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NicSoilE8_07160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NicSoilE8_07170	COG0514	ATP-dependent DNA helicase (RecQ)
NicSoilE8_07200	COG1505	serine-type exopeptidase activity
NicSoilE8_07220	COG1113	amino acid transport
NicSoilE8_07240	COG0604	alcohol dehydrogenase
NicSoilE8_07240	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_07240	COG3321	synthase
NicSoilE8_07260	COG1966	Carbon starvation protein
NicSoilE8_07300	COG0656	L-ascorbic acid biosynthetic process
NicSoilE8_07330	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilE8_07410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NicSoilE8_07420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NicSoilE8_07470	COG0588	phosphoglycerate mutase activity
NicSoilE8_07490	COG5002	protein histidine kinase activity
NicSoilE8_07540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NicSoilE8_07550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NicSoilE8_07570	COG0215	cysteine-tRNA ligase activity
NicSoilE8_07660	COG0366	Alpha amylase catalytic
NicSoilE8_07680	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NicSoilE8_07710	COG0277	FAD linked oxidase domain protein
NicSoilE8_07770	COG3842	ATPase activity
NicSoilE8_07820	COG0475	glutathione-regulated potassium exporter activity
NicSoilE8_07830	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_07860	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NicSoilE8_07870	COG0588	phosphoglycerate mutase activity
NicSoilE8_07880	COG1252	NADH dehydrogenase
NicSoilE8_07960	COG0579	oxidoreductase
NicSoilE8_08000	COG2957	Belongs to the agmatine deiminase family
NicSoilE8_08030	COG0492	ferredoxin-NADP+ reductase activity
NicSoilE8_08050	COG1609	Transcriptional regulator
NicSoilE8_08080	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
NicSoilE8_08100	COG4786	Flagellar basal body rod
NicSoilE8_08100	COG1256	bacterial-type flagellum assembly
NicSoilE8_08120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NicSoilE8_08180	COG1815	bacterial-type flagellum-dependent cell motility
NicSoilE8_08200	COG1677	Flagellar hook-basal body complex protein FliE
NicSoilE8_08210	COG1766	The M ring may be actively involved in energy transduction
NicSoilE8_08220	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NicSoilE8_08240	COG1157	protein secretion by the type III secretion system
NicSoilE8_08260	COG0791	NLP P60 protein
NicSoilE8_08300	COG3550	peptidyl-serine autophosphorylation
NicSoilE8_08330	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NicSoilE8_08340	COG1360	Flagellar Motor Protein
NicSoilE8_08390	COG1338	Plays a role in the flagellum-specific transport system
NicSoilE8_08420	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NicSoilE8_08430	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NicSoilE8_08450	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NicSoilE8_08480	COG0477	Major facilitator Superfamily
NicSoilE8_08500	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NicSoilE8_08500	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NicSoilE8_08510	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NicSoilE8_08520	COG0509	glycine decarboxylation via glycine cleavage system
NicSoilE8_08540	COG1864	DNA RNA non-specific endonuclease
NicSoilE8_08540	COG3591	Belongs to the peptidase S1B family
NicSoilE8_08590	COG0577	efflux transmembrane transporter activity
NicSoilE8_08590	COG1136	(ABC) transporter
NicSoilE8_08640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NicSoilE8_08680	COG0459	protein refolding
NicSoilE8_08690	COG0328	RNA-DNA hybrid ribonuclease activity
NicSoilE8_08710	COG2205	protein histidine kinase activity
NicSoilE8_08720	COG0745	RESPONSE REGULATOR receiver
NicSoilE8_08760	COG2132	Multicopper oxidase
NicSoilE8_08810	COG1278	Cold shock
NicSoilE8_08830	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NicSoilE8_08850	COG0739	heme binding
NicSoilE8_08860	COG0791	NLP P60 protein
NicSoilE8_08860	COG1388	LysM domain
NicSoilE8_08860	COG3103	Sh3 type 3 domain protein
NicSoilE8_08890	COG0746	molybdenum cofactor guanylyltransferase activity
NicSoilE8_08910	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NicSoilE8_08950	COG1126	abc transporter atp-binding protein
NicSoilE8_08960	COG0765	amino acid transport
NicSoilE8_08970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NicSoilE8_09000	COG0488	(ABC) transporter
NicSoilE8_09010	COG1132	(ABC) transporter
NicSoilE8_09070	COG0483	inositol monophosphate 1-phosphatase activity
NicSoilE8_09100	COG0045	succinate-CoA ligase (ADP-forming) activity
NicSoilE8_09120	COG1942	4-Oxalocrotonate Tautomerase
NicSoilE8_09130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NicSoilE8_09150	COG3962	Belongs to the TPP enzyme family
NicSoilE8_09180	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_09190	COG1082	Xylose isomerase domain protein TIM barrel
NicSoilE8_09200	COG3718	enzyme involved in inositol metabolism
NicSoilE8_09210	COG2188	Transcriptional regulator
NicSoilE8_09230	COG1172	Belongs to the binding-protein-dependent transport system permease family
NicSoilE8_09250	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_09340	COG1396	sequence-specific DNA binding
NicSoilE8_09360	COG0028	Belongs to the TPP enzyme family
NicSoilE8_09420	COG3142	Participates in the control of copper homeostasis
NicSoilE8_09450	COG1401	restriction endodeoxyribonuclease activity
NicSoilE8_09510	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilE8_09520	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_09540	COG1024	Enoyl-CoA hydratase
NicSoilE8_09550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NicSoilE8_09580	COG1396	sequence-specific DNA binding
NicSoilE8_09620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NicSoilE8_09660	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NicSoilE8_09670	COG1902	pentaerythritol trinitrate reductase activity
NicSoilE8_09700	COG2376	Dihydroxyacetone kinase
NicSoilE8_09710	COG0698	ribose 5-phosphate isomerase
NicSoilE8_09720	COG1250	3-hydroxyacyl-CoA dehydrogenase
NicSoilE8_09730	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_09740	COG2271	Major facilitator Superfamily
NicSoilE8_09750	COG0149	triose-phosphate isomerase activity
NicSoilE8_09820	COG1984	allophanate hydrolase subunit 2
NicSoilE8_09830	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NicSoilE8_09840	COG0439	Biotin carboxylase
NicSoilE8_09850	COG0511	ligase activity, forming carbon-carbon bonds
NicSoilE8_09870	COG3835	regulator
NicSoilE8_09880	COG2801	Transposase and inactivated derivatives
NicSoilE8_09880	COG3415	Transposase
NicSoilE8_09910	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NicSoilE8_09930	COG1254	Belongs to the acylphosphatase family
NicSoilE8_09950	COG0640	Transcriptional regulator
NicSoilE8_10020	COG1472	Belongs to the glycosyl hydrolase 3 family
NicSoilE8_10030	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_10060	COG1609	Transcriptional regulator
NicSoilE8_10100	COG0477	Major facilitator Superfamily
NicSoilE8_10130	COG3973	AAA domain
NicSoilE8_10210	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NicSoilE8_10310	COG1136	(ABC) transporter
NicSoilE8_10310	COG0577	efflux transmembrane transporter activity
NicSoilE8_10330	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_10380	COG4942	peptidase
NicSoilE8_10390	COG1278	Cold shock
NicSoilE8_10450	COG0071	Belongs to the small heat shock protein (HSP20) family
NicSoilE8_10520	COG2271	Major facilitator Superfamily
NicSoilE8_10530	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NicSoilE8_10550	COG0138	bifunctional purine biosynthesis protein purh
NicSoilE8_10570	COG2838	Isocitrate dehydrogenase
NicSoilE8_10600	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_10620	COG0577	efflux transmembrane transporter activity
NicSoilE8_10620	COG1136	(ABC) transporter
NicSoilE8_10630	COG0577	efflux transmembrane transporter activity
NicSoilE8_10630	COG1136	(ABC) transporter
NicSoilE8_10640	COG4213	ABC transporter substrate-binding protein
NicSoilE8_10650	COG4214	carbohydrate transport
NicSoilE8_10660	COG1129	ABC transporter
NicSoilE8_10710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NicSoilE8_10720	COG0531	amino acid
NicSoilE8_10770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NicSoilE8_10780	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NicSoilE8_10790	COG1131	(ABC) transporter
NicSoilE8_10840	COG0180	Tryptophanyl-tRNA synthetase
NicSoilE8_10910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NicSoilE8_10940	COG2009	succinate dehydrogenase
NicSoilE8_10960	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NicSoilE8_10960	COG1473	amidohydrolase
NicSoilE8_10970	COG1846	Transcriptional regulator
NicSoilE8_10980	COG1764	response to oxidative stress
NicSoilE8_10990	COG2130	NADP-dependent
NicSoilE8_11000	COG1744	ABC transporter substrate-binding protein PnrA-like
NicSoilE8_11010	COG3845	ABC transporter
NicSoilE8_11020	COG4603	Belongs to the binding-protein-dependent transport system permease family
NicSoilE8_11030	COG1079	Belongs to the binding-protein-dependent transport system permease family
NicSoilE8_11070	COG0586	Pfam SNARE associated Golgi protein
NicSoilE8_11080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NicSoilE8_11100	COG0148	phosphopyruvate hydratase activity
NicSoilE8_11150	COG1252	NADH dehydrogenase
NicSoilE8_11220	COG0559	Belongs to the binding-protein-dependent transport system permease family
NicSoilE8_11240	COG0183	Belongs to the thiolase family
NicSoilE8_11250	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NicSoilE8_11270	COG2017	converts alpha-aldose to the beta-anomer
NicSoilE8_11290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NicSoilE8_11310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NicSoilE8_11330	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NicSoilE8_11350	COG1331	Highly conserved protein containing a thioredoxin domain
NicSoilE8_11370	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NicSoilE8_11380	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NicSoilE8_11420	COG0114	fumarate hydratase activity
NicSoilE8_11430	COG0288	reversible hydration of carbon dioxide
NicSoilE8_11450	COG1494	fructose-1,6-bisphosphatase
NicSoilE8_11470	COG1482	cell wall glycoprotein biosynthetic process
NicSoilE8_11490	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NicSoilE8_11590	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NicSoilE8_11600	COG1376	ErfK ybiS ycfS ynhG family protein
NicSoilE8_11700	COG0714	Associated with various cellular activities
NicSoilE8_11710	COG0084	hydrolase, TatD family'
NicSoilE8_11720	COG3583	domain protein
NicSoilE8_11730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NicSoilE8_11740	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NicSoilE8_11750	COG0488	(ABC) transporter
NicSoilE8_11780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NicSoilE8_11790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NicSoilE8_11800	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NicSoilE8_11810	COG0193	aminoacyl-tRNA hydrolase activity
NicSoilE8_11860	COG0822	iron-sulfur transferase activity
NicSoilE8_11870	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NicSoilE8_11900	COG0702	epimerase
NicSoilE8_11920	COG1988	membrane-bound metal-dependent
NicSoilE8_11960	COG0297	glycogen (starch) synthase activity
NicSoilE8_11990	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NicSoilE8_12000	COG0446	pyridine nucleotide-disulphide oxidoreductase
NicSoilE8_12080	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_12100	COG2814	Major facilitator Superfamily
NicSoilE8_12110	COG2824	Alkylphosphonate utilization operon protein PhnA
NicSoilE8_12120	COG0659	secondary active sulfate transmembrane transporter activity
NicSoilE8_12160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NicSoilE8_12180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NicSoilE8_12190	COG1621	beta-fructofuranosidase activity
NicSoilE8_12240	COG0243	molybdopterin cofactor binding
NicSoilE8_12250	COG2223	nitrite transmembrane transporter activity
NicSoilE8_12260	COG0477	Major facilitator Superfamily
NicSoilE8_12270	COG4770	biotin carboxylase activity
NicSoilE8_12280	COG0424	maF-like protein
NicSoilE8_12290	COG2409	Drug exporters of the RND superfamily
NicSoilE8_12300	COG1309	transcriptional regulator
NicSoilE8_12330	COG1823	symporter activity
NicSoilE8_12360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NicSoilE8_12430	COG0714	Associated with various cellular activities
NicSoilE8_12510	COG1674	ftsk spoiiie
NicSoilE8_12540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NicSoilE8_12550	COG0483	inositol monophosphate 1-phosphatase activity
NicSoilE8_12560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilE8_12590	COG0251	oxidation-reduction process
NicSoilE8_12600	COG4565	transcriptional regulatory protein
NicSoilE8_12620	COG2851	Citrate transporter
NicSoilE8_12630	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NicSoilE8_12640	COG0154	amidase activity
NicSoilE8_12650	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NicSoilE8_12660	COG4209	transmembrane transport
NicSoilE8_12670	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_12700	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_12720	COG1063	alcohol dehydrogenase
NicSoilE8_12730	COG0156	8-amino-7-oxononanoate synthase activity
NicSoilE8_12750	COG1228	amidohydrolase
NicSoilE8_12760	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NicSoilE8_12770	COG1940	carbohydrate kinase activity
NicSoilE8_12790	COG0191	fructose-bisphosphate aldolase activity
NicSoilE8_12830	COG2873	o-acetylhomoserine
NicSoilE8_12840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NicSoilE8_12920	COG0423	glycine-tRNA ligase activity
NicSoilE8_12970	COG0358	DNA primase activity
NicSoilE8_12990	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NicSoilE8_13000	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NicSoilE8_13060	COG0297	glycogen (starch) synthase activity
NicSoilE8_13110	COG0052	Belongs to the universal ribosomal protein uS2 family
NicSoilE8_13120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NicSoilE8_13130	COG0528	UMP kinase activity
NicSoilE8_13140	COG0233	cytoplasmic translational termination
NicSoilE8_13190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NicSoilE8_13220	COG3275	phosphorelay sensor kinase activity
NicSoilE8_13240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NicSoilE8_13250	COG1796	DNA polymerase
NicSoilE8_13250	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NicSoilE8_13270	COG1522	sequence-specific DNA binding
NicSoilE8_13290	COG0022	dehydrogenase e1 component
NicSoilE8_13300	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilE8_13310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NicSoilE8_13330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NicSoilE8_13350	COG1960	acyl-CoA dehydrogenase activity
NicSoilE8_13430	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_13450	COG1175	transmembrane transport
NicSoilE8_13460	COG1653	transport
NicSoilE8_13490	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NicSoilE8_13500	COG0750	zinc metalloprotease
NicSoilE8_13520	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NicSoilE8_13570	COG1131	(ABC) transporter
NicSoilE8_13590	COG0442	prolyl-tRNA aminoacylation
NicSoilE8_13630	COG0779	Required for maturation of 30S ribosomal subunits
NicSoilE8_13680	COG0481	GTPase activity
NicSoilE8_13680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NicSoilE8_13690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NicSoilE8_13700	COG0590	tRNA wobble adenosine to inosine editing
NicSoilE8_13720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NicSoilE8_13760	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NicSoilE8_13770	COG1185	polyribonucleotide nucleotidyltransferase activity
NicSoilE8_13780	COG0612	Peptidase, M16
NicSoilE8_13820	COG0745	RESPONSE REGULATOR receiver
NicSoilE8_13830	COG2205	protein histidine kinase activity
NicSoilE8_13870	COG0521	Mo-molybdopterin cofactor biosynthetic process
NicSoilE8_13890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NicSoilE8_13930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NicSoilE8_13940	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NicSoilE8_13950	COG1674	ftsk spoiiie
NicSoilE8_13970	COG1058	Belongs to the CinA family
NicSoilE8_13970	COG1546	Belongs to the CinA family
NicSoilE8_13980	COG1396	sequence-specific DNA binding
NicSoilE8_14020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NicSoilE8_14030	COG2137	regulation of response to DNA damage stimulus
NicSoilE8_14040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NicSoilE8_14050	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NicSoilE8_14060	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NicSoilE8_14070	COG2813	Specifically methylates the guanine in position
NicSoilE8_14080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NicSoilE8_14100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NicSoilE8_14110	COG1388	LysM domain
NicSoilE8_14120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NicSoilE8_14130	COG0131	Imidazoleglycerol-phosphate dehydratase
NicSoilE8_14140	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NicSoilE8_14160	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NicSoilE8_14200	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NicSoilE8_14210	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NicSoilE8_14220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NicSoilE8_14230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NicSoilE8_14240	COG2814	Major facilitator Superfamily
NicSoilE8_14250	COG2816	NAD+ diphosphatase activity
NicSoilE8_14270	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
NicSoilE8_14300	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NicSoilE8_14310	COG0072	phenylalanine-tRNA ligase activity
NicSoilE8_14310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NicSoilE8_14340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NicSoilE8_14350	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NicSoilE8_14360	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NicSoilE8_14370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NicSoilE8_14380	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NicSoilE8_14390	COG1438	arginine binding
NicSoilE8_14400	COG0137	argininosuccinate synthase activity
NicSoilE8_14410	COG0165	Argininosuccinate lyase
NicSoilE8_14440	COG2094	Belongs to the DNA glycosylase MPG family
NicSoilE8_14460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NicSoilE8_14490	COG0647	UMP catabolic process
NicSoilE8_14520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NicSoilE8_14530	COG0497	DNA recombination
NicSoilE8_14540	COG0504	CTP synthase activity
NicSoilE8_14600	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NicSoilE8_14610	COG2079	MmgE PrpD family protein
NicSoilE8_14640	COG3290	protein histidine kinase activity
NicSoilE8_14650	COG1301	dicarboxylic acid transport
NicSoilE8_14670	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NicSoilE8_14680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NicSoilE8_14710	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NicSoilE8_14730	COG1160	GTP binding
NicSoilE8_14740	COG1846	Transcriptional regulator
NicSoilE8_14750	COG2814	Major facilitator Superfamily
NicSoilE8_14760	COG0509	glycine decarboxylation via glycine cleavage system
NicSoilE8_14770	COG1716	ATPase activity
NicSoilE8_14820	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NicSoilE8_14840	COG1940	carbohydrate kinase activity
NicSoilE8_14890	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NicSoilE8_14900	COG0515	serine threonine protein kinase
NicSoilE8_14900	COG2815	serine threonine protein kinase
NicSoilE8_14910	COG3942	CHAP domain
NicSoilE8_14910	COG1388	LysM domain
NicSoilE8_14940	COG0142	geranyltranstransferase activity
NicSoilE8_14970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NicSoilE8_14990	COG2001	Belongs to the MraZ family
NicSoilE8_15000	COG0275	rRNA processing
NicSoilE8_15020	COG0768	penicillin binding
NicSoilE8_15030	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NicSoilE8_15050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NicSoilE8_15060	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NicSoilE8_15080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NicSoilE8_15090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NicSoilE8_15110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NicSoilE8_15130	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NicSoilE8_15140	COG1799	cell septum assembly
NicSoilE8_15170	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NicSoilE8_15190	COG0587	DNA-directed DNA polymerase activity
NicSoilE8_15220	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NicSoilE8_15230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NicSoilE8_15270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NicSoilE8_15280	COG0174	glutamine synthetase
NicSoilE8_15290	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NicSoilE8_15350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NicSoilE8_15360	COG0321	lipoyl(octanoyl) transferase activity
NicSoilE8_15380	COG1090	epimerase
NicSoilE8_15390	COG4946	Tricorn protease homolog
NicSoilE8_15390	COG0793	Belongs to the peptidase S41A family
NicSoilE8_15400	COG1764	response to oxidative stress
NicSoilE8_15420	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilE8_15430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NicSoilE8_15440	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NicSoilE8_15480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NicSoilE8_15540	COG1271	oxidase subunit
NicSoilE8_15550	COG1294	oxidase, subunit
NicSoilE8_15560	COG4988	ABC transporter
NicSoilE8_15600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NicSoilE8_15640	COG1435	thymidine kinase activity
NicSoilE8_15680	COG0756	dUTP diphosphatase activity
NicSoilE8_15730	COG0569	domain protein
NicSoilE8_15740	COG0531	amino acid
NicSoilE8_15750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NicSoilE8_15760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NicSoilE8_15770	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NicSoilE8_15810	COG0667	Aldo Keto reductase
NicSoilE8_15820	COG1250	3-hydroxyacyl-CoA dehydrogenase
NicSoilE8_15820	COG1024	Enoyl-CoA hydratase
NicSoilE8_15830	COG0183	Belongs to the thiolase family
NicSoilE8_15880	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NicSoilE8_15910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NicSoilE8_15950	COG3135	benzoate transporter
NicSoilE8_15970	COG0531	amino acid
NicSoilE8_16010	COG0242	peptide deformylase activity
NicSoilE8_16020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NicSoilE8_16040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NicSoilE8_16080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NicSoilE8_16080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NicSoilE8_16090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NicSoilE8_16100	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NicSoilE8_16110	COG0140	phosphoribosyl-ATP diphosphatase activity
NicSoilE8_16120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NicSoilE8_16130	COG0107	imidazoleglycerol-phosphate synthase activity
NicSoilE8_16150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NicSoilE8_16190	COG0134	indole-3-glycerol-phosphate synthase activity
NicSoilE8_16200	COG0133	tryptophan synthase activity
NicSoilE8_16210	COG0159	tryptophan synthase activity
NicSoilE8_16220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NicSoilE8_16230	COG0070	glutamate synthase
NicSoilE8_16230	COG0067	glutamate synthase
NicSoilE8_16230	COG0069	glutamate synthase activity
NicSoilE8_16470	COG3118	belongs to the thioredoxin family
NicSoilE8_16490	COG1902	pentaerythritol trinitrate reductase activity
NicSoilE8_16540	COG0318	PFAM AMP-dependent synthetase and ligase
NicSoilE8_16550	COG0765	amino acid transport
NicSoilE8_16560	COG1126	abc transporter atp-binding protein
NicSoilE8_16590	COG2072	flavoprotein involved in K transport
NicSoilE8_16600	COG1024	Enoyl-CoA hydratase
NicSoilE8_16640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NicSoilE8_16670	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NicSoilE8_16680	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NicSoilE8_16690	COG2855	membrane
NicSoilE8_16700	COG0686	Belongs to the AlaDH PNT family
NicSoilE8_16820	COG3328	transposase activity
NicSoilE8_16940	COG0561	phosphatase activity
NicSoilE8_16990	COG2814	Major facilitator Superfamily
NicSoilE8_17030	COG1172	Belongs to the binding-protein-dependent transport system permease family
NicSoilE8_17050	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilE8_17060	COG3962	Belongs to the TPP enzyme family
NicSoilE8_17070	COG3836	Belongs to the HpcH HpaI aldolase family
NicSoilE8_17080	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_17090	COG1609	Transcriptional regulator
NicSoilE8_17100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NicSoilE8_17110	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_17120	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_17180	COG1942	4-Oxalocrotonate Tautomerase
NicSoilE8_17200	COG2963	transposase activity
NicSoilE8_17220	COG3265	gluconokinase activity
NicSoilE8_17270	COG0436	Aminotransferase
NicSoilE8_17320	COG0477	Major facilitator Superfamily
NicSoilE8_17370	COG4608	Belongs to the ABC transporter superfamily
NicSoilE8_17400	COG0477	Major facilitator Superfamily
NicSoilE8_17440	COG0277	FAD linked oxidase domain protein
NicSoilE8_17440	COG0247	lactate metabolic process
NicSoilE8_17450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NicSoilE8_17470	COG2814	Major facilitator Superfamily
NicSoilE8_17480	COG0402	S-adenosylhomocysteine deaminase activity
NicSoilE8_17530	COG0531	amino acid
NicSoilE8_17540	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NicSoilE8_17580	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_17590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NicSoilE8_17620	COG0765	amino acid transport
NicSoilE8_17740	COG2963	transposase activity
NicSoilE8_17800	COG1349	DNA-binding transcription factor activity
NicSoilE8_17810	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NicSoilE8_17890	COG3415	Transposase
NicSoilE8_17890	COG2801	Transposase and inactivated derivatives
NicSoilE8_17970	COG2217	Heavy metal translocating P-type atpase
NicSoilE8_17980	COG2132	Multicopper oxidase
NicSoilE8_18000	COG4702	Belongs to the UPF0303 family
NicSoilE8_18030	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilE8_18040	COG1024	Enoyl-CoA hydratase
NicSoilE8_18060	COG4670	ketone body catabolic process
NicSoilE8_18070	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_18080	COG1609	Transcriptional regulator
NicSoilE8_18100	COG1175	transmembrane transport
NicSoilE8_18110	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_18130	COG0800	Aldolase
NicSoilE8_18150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NicSoilE8_18190	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_18200	COG1175	transmembrane transport
NicSoilE8_18220	COG3684	Belongs to the aldolase LacD family
NicSoilE8_18240	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_18250	COG1349	DNA-binding transcription factor activity
NicSoilE8_18270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NicSoilE8_18280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NicSoilE8_18290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NicSoilE8_18330	COG1609	Transcriptional regulator
NicSoilE8_18360	COG1172	Belongs to the binding-protein-dependent transport system permease family
NicSoilE8_18370	COG1129	ABC transporter
NicSoilE8_18440	COG1131	(ABC) transporter
NicSoilE8_18470	COG0726	polysaccharide deacetylase
NicSoilE8_18500	COG1131	(ABC) transporter
NicSoilE8_18540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NicSoilE8_18540	COG0574	Belongs to the PEP-utilizing enzyme family
NicSoilE8_18560	COG1937	Protein conserved in bacteria
NicSoilE8_18600	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NicSoilE8_18620	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilE8_18630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NicSoilE8_18690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NicSoilE8_18780	COG0280	phosphate acetyltransferase
NicSoilE8_18780	COG0857	belongs to the CobB CobQ family
NicSoilE8_18830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NicSoilE8_18840	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NicSoilE8_18900	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NicSoilE8_18910	COG0179	Fumarylacetoacetate (FAA) hydrolase
NicSoilE8_18950	COG3962	Belongs to the TPP enzyme family
NicSoilE8_18960	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilE8_18970	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_18980	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_18990	COG0129	dihydroxy-acid dehydratase activity
NicSoilE8_19000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NicSoilE8_19020	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_19030	COG1129	ABC transporter
NicSoilE8_19040	COG1172	Belongs to the binding-protein-dependent transport system permease family
NicSoilE8_19090	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NicSoilE8_19100	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NicSoilE8_19110	COG1228	amidohydrolase
NicSoilE8_19130	COG3842	ATPase activity
NicSoilE8_19170	COG0477	Major facilitator Superfamily
NicSoilE8_19180	COG2175	clavaminate synthase activity
NicSoilE8_19200	COG2080	2 iron, 2 sulfur cluster binding
NicSoilE8_19220	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NicSoilE8_19220	COG3608	succinylglutamate desuccinylase aspartoacylase
NicSoilE8_19230	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilE8_19280	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_19350	COG1846	Transcriptional regulator
NicSoilE8_19360	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
NicSoilE8_19370	COG2197	response regulator
NicSoilE8_19470	COG0572	uridine kinase
NicSoilE8_19510	COG0251	oxidation-reduction process
NicSoilE8_19520	COG0179	Fumarylacetoacetate (FAA) hydrolase
NicSoilE8_19570	COG2814	Major facilitator Superfamily
NicSoilE8_19640	COG3971	2-oxopent-4-enoate hydratase activity
NicSoilE8_19670	COG1802	Transcriptional regulator
NicSoilE8_19700	COG0028	Belongs to the TPP enzyme family
NicSoilE8_19710	COG1793	dna ligase
NicSoilE8_19710	COG3285	dna ligase
NicSoilE8_19740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NicSoilE8_19790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NicSoilE8_19820	COG1064	alcohol dehydrogenase
NicSoilE8_19830	COG1643	Atp-dependent helicase
NicSoilE8_19890	COG0009	L-threonylcarbamoyladenylate synthase
NicSoilE8_19930	COG2971	BadF BadG BcrA BcrD
NicSoilE8_19960	COG3483	tryptophan 2,3-dioxygenase activity
NicSoilE8_20030	COG2050	protein possibly involved in aromatic compounds catabolism
NicSoilE8_20050	COG4552	Acetyltransferase involved in intracellular survival and related
NicSoilE8_20060	COG0539	negative regulation of cytoplasmic translation
NicSoilE8_20070	COG1739	Uncharacterized protein family UPF0029
NicSoilE8_20080	COG0237	dephospho-CoA kinase activity
NicSoilE8_20080	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NicSoilE8_20090	COG0556	nucleotide-excision repair
NicSoilE8_20150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NicSoilE8_20170	COG4106	trans-aconitate 2-methyltransferase activity
NicSoilE8_20200	COG0546	phosphoglycolate phosphatase activity
NicSoilE8_20220	COG0322	excinuclease ABC activity
NicSoilE8_20230	COG1660	Displays ATPase and GTPase activities
NicSoilE8_20250	COG1481	regulation of sporulation
NicSoilE8_20260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NicSoilE8_20270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NicSoilE8_20280	COG0126	phosphoglycerate kinase activity
NicSoilE8_20290	COG0149	triose-phosphate isomerase activity
NicSoilE8_20300	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NicSoilE8_20320	COG0363	glucosamine-6-phosphate deaminase activity
NicSoilE8_20350	COG0166	Belongs to the GPI family
NicSoilE8_20360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NicSoilE8_20380	COG0109	protoheme IX farnesyltransferase activity
NicSoilE8_20390	COG1612	heme a metabolic process
NicSoilE8_20410	COG1131	(ABC) transporter
NicSoilE8_20460	COG0396	ATPase activity
NicSoilE8_20470	COG2151	metal-sulfur cluster biosynthetic enzyme
NicSoilE8_20490	COG0318	PFAM AMP-dependent synthetase and ligase
NicSoilE8_20520	COG1122	ATPase activity
NicSoilE8_20530	COG1268	BioY protein
NicSoilE8_20540	COG0488	(ABC) transporter
NicSoilE8_20590	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_20600	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_20610	COG1129	ABC transporter
NicSoilE8_20630	COG0560	Phosphoserine phosphatase
NicSoilE8_20630	COG3830	Belongs to the UPF0237 family
NicSoilE8_20640	COG1119	ATPase activity
NicSoilE8_20670	COG0254	rRNA binding
NicSoilE8_20720	COG1305	Transglutaminase-like
NicSoilE8_20740	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NicSoilE8_20760	COG0297	glycogen (starch) synthase activity
NicSoilE8_20770	COG1960	acyl-CoA dehydrogenase activity
NicSoilE8_20790	COG0183	Belongs to the thiolase family
NicSoilE8_20800	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_20860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NicSoilE8_20870	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_21010	COG1088	dTDP-glucose 4,6-dehydratase activity
NicSoilE8_21020	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NicSoilE8_21030	COG0656	L-ascorbic acid biosynthetic process
NicSoilE8_21040	COG1968	undecaprenyl-diphosphatase activity
NicSoilE8_21050	COG0215	cysteine-tRNA ligase activity
NicSoilE8_21070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NicSoilE8_21100	COG1222	aaa ATPase
NicSoilE8_21110	COG4122	O-methyltransferase activity
NicSoilE8_21130	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NicSoilE8_21140	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NicSoilE8_21150	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NicSoilE8_21160	COG0545	Peptidyl-prolyl cis-trans isomerase
NicSoilE8_21200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NicSoilE8_21210	COG0805	protein transport
NicSoilE8_21220	COG4581	dead DEAH box helicase
NicSoilE8_21230	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NicSoilE8_21240	COG1216	Glycosyl transferase, family 2
NicSoilE8_21280	COG2226	methyltransferase
NicSoilE8_21290	COG4946	Tricorn protease homolog
NicSoilE8_21290	COG1506	peptidase
NicSoilE8_21290	COG0823	Involved in the tonB-independent uptake of proteins
NicSoilE8_21300	COG0242	peptide deformylase activity
NicSoilE8_21330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NicSoilE8_21340	COG3424	synthase
NicSoilE8_21360	COG0667	Aldo Keto reductase
NicSoilE8_21440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NicSoilE8_21450	COG1845	cytochrome c oxidase, subunit III
NicSoilE8_21460	COG2010	Cytochrome c
NicSoilE8_21470	COG0723	plastoquinol--plastocyanin reductase activity
NicSoilE8_21480	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NicSoilE8_21490	COG2186	Transcriptional regulator
NicSoilE8_21500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NicSoilE8_21520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NicSoilE8_21530	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NicSoilE8_21570	COG0167	dihydroorotate dehydrogenase activity
NicSoilE8_21600	COG2267	carboxylic ester hydrolase activity
NicSoilE8_21610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NicSoilE8_21620	COG1381	Involved in DNA repair and RecF pathway recombination
NicSoilE8_21630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NicSoilE8_21640	COG3590	peptidase
NicSoilE8_21650	COG1316	TRANSCRIPTIONal
NicSoilE8_21660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NicSoilE8_21680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NicSoilE8_21720	COG0484	heat shock protein binding
NicSoilE8_21730	COG1420	regulation of RNA biosynthetic process
NicSoilE8_21770	COG0481	GTPase activity
NicSoilE8_21790	COG0268	Binds directly to 16S ribosomal RNA
NicSoilE8_21830	COG1307	EDD domain protein, DegV family
NicSoilE8_21840	COG0495	leucyl-tRNA aminoacylation
NicSoilE8_21850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NicSoilE8_21860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NicSoilE8_21870	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NicSoilE8_21880	COG2390	Transcriptional regulator
NicSoilE8_21890	COG0656	L-ascorbic acid biosynthetic process
NicSoilE8_21910	COG0438	transferase activity, transferring glycosyl groups
NicSoilE8_21940	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NicSoilE8_21960	COG1758	RNA polymerase activity
NicSoilE8_21970	COG0194	GDP metabolic process
NicSoilE8_21990	COG0284	orotidine-5'-phosphate decarboxylase activity
NicSoilE8_22000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NicSoilE8_22010	COG0505	Belongs to the CarA family
NicSoilE8_22030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NicSoilE8_22040	COG0540	Belongs to the ATCase OTCase family
NicSoilE8_22050	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NicSoilE8_22070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NicSoilE8_22080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NicSoilE8_22100	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NicSoilE8_22110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NicSoilE8_22120	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NicSoilE8_22130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NicSoilE8_22130	COG0710	3-dehydroquinate dehydratase activity
NicSoilE8_22160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NicSoilE8_22190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NicSoilE8_22230	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NicSoilE8_22240	COG0124	histidyl-tRNA synthetase
NicSoilE8_22260	COG1196	nuclear chromosome segregation
NicSoilE8_22280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NicSoilE8_22290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NicSoilE8_22300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NicSoilE8_22320	COG2255	four-way junction helicase activity
NicSoilE8_22330	COG0632	four-way junction helicase activity
NicSoilE8_22340	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NicSoilE8_22350	COG0217	transcriptional regulatory protein
NicSoilE8_22360	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NicSoilE8_22400	COG0339	signal peptide processing
NicSoilE8_22410	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NicSoilE8_22420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NicSoilE8_22440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NicSoilE8_22450	COG0587	DNA-directed DNA polymerase activity
NicSoilE8_22500	COG2135	peptidase activity
NicSoilE8_22530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NicSoilE8_22600	COG4804	nuclease activity
NicSoilE8_22640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NicSoilE8_22660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NicSoilE8_22670	COG1780	Probably involved in ribonucleotide reductase function
NicSoilE8_22690	COG0583	DNA-binding transcription factor activity
NicSoilE8_22770	COG0714	Associated with various cellular activities
NicSoilE8_22800	COG2813	Specifically methylates the guanine in position
NicSoilE8_22820	COG0799	negative regulation of ribosome biogenesis
NicSoilE8_22840	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NicSoilE8_22860	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NicSoilE8_22870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NicSoilE8_22880	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NicSoilE8_22890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NicSoilE8_22900	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NicSoilE8_22910	COG0351	phosphomethylpyrimidine kinase
NicSoilE8_22910	COG0352	thiamine-phosphate diphosphorylase activity
NicSoilE8_22910	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NicSoilE8_22920	COG1530	ribonuclease E activity
NicSoilE8_22940	COG0105	UTP biosynthetic process
NicSoilE8_22960	COG0285	dihydrofolate synthase activity
NicSoilE8_22970	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NicSoilE8_23000	COG0525	valine-tRNA ligase activity
NicSoilE8_23010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NicSoilE8_23020	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NicSoilE8_23030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NicSoilE8_23040	COG0740	serine-type endopeptidase activity
NicSoilE8_23050	COG0740	serine-type endopeptidase activity
NicSoilE8_23060	COG0544	peptidyl-prolyl cis-trans isomerase activity
NicSoilE8_23130	COG0668	transmembrane transport
NicSoilE8_23160	COG1946	Acyl-CoA thioesterase
NicSoilE8_23190	COG0629	single-stranded DNA binding
NicSoilE8_23230	COG0242	peptide deformylase activity
NicSoilE8_23280	COG3022	response to hydroperoxide
NicSoilE8_23300	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NicSoilE8_23310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NicSoilE8_23330	COG1045	serine acetyltransferase
NicSoilE8_23340	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NicSoilE8_23360	COG1063	alcohol dehydrogenase
NicSoilE8_23370	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_23380	COG2084	Dehydrogenase
NicSoilE8_23410	COG0477	Major facilitator Superfamily
NicSoilE8_23470	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NicSoilE8_23500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NicSoilE8_23510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NicSoilE8_23540	COG4974	Belongs to the 'phage' integrase family
NicSoilE8_23570	COG0792	nuclease activity
NicSoilE8_23590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NicSoilE8_23610	COG0681	Belongs to the peptidase S26 family
NicSoilE8_23620	COG0335	large ribosomal subunit rRNA binding
NicSoilE8_23630	COG0336	Belongs to the RNA methyltransferase TrmD family
NicSoilE8_23640	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NicSoilE8_23650	COG1837	Belongs to the UPF0109 family
NicSoilE8_23660	COG0228	four-way junction DNA binding
NicSoilE8_23680	COG2514	catechol 2,3-dioxygenase activity
NicSoilE8_23740	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NicSoilE8_23770	COG2814	Major facilitator Superfamily
NicSoilE8_23850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NicSoilE8_23860	COG0571	ribonuclease III activity
NicSoilE8_23870	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NicSoilE8_23890	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NicSoilE8_23930	COG0742	ribosomal rna small subunit methyltransferase
NicSoilE8_23950	COG1461	Dihydroxyacetone kinase
NicSoilE8_23980	COG1181	Belongs to the D-alanine--D-alanine ligase family
NicSoilE8_23990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NicSoilE8_24010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NicSoilE8_24020	COG0066	3-isopropylmalate dehydratase activity
NicSoilE8_24030	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NicSoilE8_24040	COG1414	Transcriptional regulator
NicSoilE8_24090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NicSoilE8_24110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NicSoilE8_24120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NicSoilE8_24130	COG0473	3-isopropylmalate dehydrogenase activity
NicSoilE8_24140	COG4585	Histidine kinase
NicSoilE8_24150	COG2197	response regulator
NicSoilE8_24160	COG1136	(ABC) transporter
NicSoilE8_24190	COG0577	efflux transmembrane transporter activity
NicSoilE8_24190	COG1136	(ABC) transporter
NicSoilE8_24210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NicSoilE8_24220	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NicSoilE8_24230	COG0440	acetolactate synthase activity
NicSoilE8_24250	COG0129	dihydroxy-acid dehydratase activity
NicSoilE8_24270	COG2133	pyrroloquinoline quinone binding
NicSoilE8_24300	COG0747	negative chemotaxis
NicSoilE8_24310	COG0579	oxidoreductase
NicSoilE8_24320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NicSoilE8_24330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilE8_24340	COG1846	Transcriptional regulator
NicSoilE8_24350	COG1305	Transglutaminase-like
NicSoilE8_24370	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NicSoilE8_24380	COG0179	Fumarylacetoacetate (FAA) hydrolase
NicSoilE8_24400	COG1104	cysteine desulfurase activity
NicSoilE8_24420	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NicSoilE8_24430	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NicSoilE8_24450	COG1522	sequence-specific DNA binding
NicSoilE8_24460	COG1113	amino acid transport
NicSoilE8_24480	COG0022	dehydrogenase e1 component
NicSoilE8_24490	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilE8_24530	COG0477	Major facilitator Superfamily
NicSoilE8_24540	COG1414	Transcriptional regulator
NicSoilE8_24560	COG0419	ATPase involved in DNA repair
NicSoilE8_24570	COG0420	3'-5' exonuclease activity
NicSoilE8_24600	COG2149	membrane
NicSoilE8_24650	COG1131	(ABC) transporter
NicSoilE8_24680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NicSoilE8_24690	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NicSoilE8_24700	COG1234	tRNA 3'-trailer cleavage
NicSoilE8_24710	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NicSoilE8_24730	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NicSoilE8_24750	COG1335	isochorismatase
NicSoilE8_24780	COG0363	glucosamine-6-phosphate deaminase activity
NicSoilE8_24810	COG1902	pentaerythritol trinitrate reductase activity
NicSoilE8_24880	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
NicSoilE8_24890	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NicSoilE8_24910	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NicSoilE8_24920	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NicSoilE8_24940	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NicSoilE8_24950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NicSoilE8_24960	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NicSoilE8_24970	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NicSoilE8_24980	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NicSoilE8_24990	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NicSoilE8_25000	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NicSoilE8_25010	COG0356	it plays a direct role in the translocation of protons across the membrane
NicSoilE8_25040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NicSoilE8_25080	COG0009	L-threonylcarbamoyladenylate synthase
NicSoilE8_25090	COG2890	protein-(glutamine-N5) methyltransferase activity
NicSoilE8_25100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NicSoilE8_25120	COG0083	homoserine kinase activity
NicSoilE8_25130	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NicSoilE8_25140	COG0460	homoserine dehydrogenase
NicSoilE8_25150	COG0019	diaminopimelate decarboxylase activity
NicSoilE8_25160	COG0018	arginyl-trna synthetase
NicSoilE8_25190	COG1017	nitric oxide dioxygenase activity
NicSoilE8_25190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NicSoilE8_25250	COG1643	Atp-dependent helicase
NicSoilE8_25260	COG0537	adenosine 5'-monophosphoramidase activity
NicSoilE8_25270	COG1064	alcohol dehydrogenase
NicSoilE8_25320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NicSoilE8_25330	COG1121	(ABC) transporter
NicSoilE8_25340	COG0803	Belongs to the bacterial solute-binding protein 9 family
NicSoilE8_25360	COG1253	flavin adenine dinucleotide binding
NicSoilE8_25370	COG0567	Dehydrogenase, E1 component
NicSoilE8_25370	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilE8_25420	COG1595	DNA-templated transcription, initiation
NicSoilE8_25440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NicSoilE8_25460	COG0483	inositol monophosphate 1-phosphatase activity
NicSoilE8_25470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NicSoilE8_25530	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NicSoilE8_25550	COG2177	Part of the ABC transporter FtsEX involved in
NicSoilE8_25560	COG2884	Cell division ATP-binding protein ftsE
NicSoilE8_25570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NicSoilE8_25750	COG1216	Glycosyl transferase, family 2
NicSoilE8_25780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NicSoilE8_25810	COG1674	ftsk spoiiie
NicSoilE8_25850	COG2902	Dehydrogenase
NicSoilE8_25920	COG0653	protein targeting
NicSoilE8_25930	COG3214	Protein conserved in bacteria
NicSoilE8_25940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NicSoilE8_25950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NicSoilE8_25960	COG5401	PFAM Sporulation and spore germination
NicSoilE8_25970	COG5000	phosphorelay sensor kinase activity
NicSoilE8_25970	COG5002	protein histidine kinase activity
NicSoilE8_25980	COG0745	RESPONSE REGULATOR receiver
NicSoilE8_26020	COG0714	Associated with various cellular activities
NicSoilE8_26090	COG0601	transmembrane transport
NicSoilE8_26140	COG0482	sulfurtransferase activity
NicSoilE8_26200	COG0484	heat shock protein binding
NicSoilE8_26210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NicSoilE8_26220	COG1595	DNA-templated transcription, initiation
NicSoilE8_26240	COG3265	gluconokinase activity
NicSoilE8_26250	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NicSoilE8_26260	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NicSoilE8_26270	COG2086	electron transfer activity
NicSoilE8_26280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NicSoilE8_26300	COG1842	Phage shock protein A
NicSoilE8_26320	COG1615	UPF0182 protein
NicSoilE8_26330	COG3480	Lon protease (S16) C-terminal proteolytic domain
NicSoilE8_26370	COG2816	NAD+ diphosphatase activity
NicSoilE8_26400	COG1074	ATP-dependent DNA helicase activity
NicSoilE8_26430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NicSoilE8_26440	COG0765	amino acid transport
NicSoilE8_26460	COG1472	Belongs to the glycosyl hydrolase 3 family
NicSoilE8_26490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NicSoilE8_26510	COG0113	porphobilinogen synthase activity
NicSoilE8_26530	COG0181	hydroxymethylbilane synthase activity
NicSoilE8_26540	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NicSoilE8_26550	COG3253	May function as heme-dependent peroxidase
NicSoilE8_26570	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NicSoilE8_26580	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NicSoilE8_26610	COG1309	transcriptional regulator
NicSoilE8_26660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NicSoilE8_26660	COG2022	thiamine diphosphate biosynthetic process
NicSoilE8_26680	COG0352	thiamine-phosphate diphosphorylase activity
NicSoilE8_26710	COG0513	Belongs to the DEAD box helicase family
NicSoilE8_26730	COG2095	MarC family integral membrane protein
NicSoilE8_26740	COG0613	PHP domain protein
NicSoilE8_26750	COG0006	proline dipeptidase activity
NicSoilE8_26770	COG2239	Acts as a magnesium transporter
NicSoilE8_26800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NicSoilE8_26820	COG1595	DNA-templated transcription, initiation
NicSoilE8_26830	COG4122	O-methyltransferase activity
NicSoilE8_26880	COG1126	abc transporter atp-binding protein
NicSoilE8_26890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NicSoilE8_26900	COG0765	amino acid transport
NicSoilE8_26910	COG0765	amino acid transport
NicSoilE8_26920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NicSoilE8_26930	COG2171	N-acyltransferase activity
NicSoilE8_26960	COG3226	Transcriptional regulator
NicSoilE8_26970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NicSoilE8_27030	COG1217	gtp-binding protein TYPA
NicSoilE8_27060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NicSoilE8_27070	COG0601	transmembrane transport
NicSoilE8_27080	COG0747	negative chemotaxis
NicSoilE8_27320	COG0012	GTP binding
NicSoilE8_27330	COG1322	Protein conserved in bacteria
NicSoilE8_27340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NicSoilE8_27360	COG1570	exodeoxyribonuclease VII activity
NicSoilE8_27370	COG1722	exodeoxyribonuclease VII activity
NicSoilE8_27380	COG2326	polyphosphate kinase activity
NicSoilE8_27420	COG1174	glycine betaine transport
NicSoilE8_27440	COG1162	GTPase activity
NicSoilE8_27470	COG2971	BadF BadG BcrA BcrD
NicSoilE8_27490	COG2814	Major facilitator Superfamily
NicSoilE8_27500	COG3548	integral membrane protein
NicSoilE8_27550	COG0598	Magnesium transport protein CorA
NicSoilE8_27560	COG1528	Iron-storage protein
NicSoilE8_27570	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NicSoilE8_27580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NicSoilE8_27600	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NicSoilE8_27610	COG1695	Transcriptional regulator
NicSoilE8_27660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NicSoilE8_27670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NicSoilE8_27710	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NicSoilE8_27710	COG0519	Catalyzes the synthesis of GMP from XMP
NicSoilE8_27750	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NicSoilE8_27790	COG0516	GMP reductase activity
NicSoilE8_27800	COG1132	(ABC) transporter
NicSoilE8_27840	COG0459	protein refolding
NicSoilE8_27850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NicSoilE8_27880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NicSoilE8_27910	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NicSoilE8_27920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NicSoilE8_27950	COG0802	atpase or kinase
NicSoilE8_27960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NicSoilE8_27980	COG1486	melibiose metabolic process
NicSoilE8_28000	COG0438	transferase activity, transferring glycosyl groups
NicSoilE8_28010	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NicSoilE8_28030	COG0667	Aldo Keto reductase
NicSoilE8_28080	COG0736	holo-[acyl-carrier-protein] synthase activity
NicSoilE8_28100	COG1072	(Pantothenic acid kinase))
NicSoilE8_28120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NicSoilE8_28130	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NicSoilE8_28140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NicSoilE8_28200	COG0455	bacterial-type flagellum organization
NicSoilE8_28240	COG0101	tRNA pseudouridine synthase activity
NicSoilE8_28250	COG0203	ribosomal protein L17
NicSoilE8_28260	COG0202	RNA polymerase activity
NicSoilE8_28270	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NicSoilE8_28280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NicSoilE8_28290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NicSoilE8_28300	COG3191	aminopeptidase activity
NicSoilE8_28340	COG0024	Methionine aminopeptidase
NicSoilE8_28360	COG0318	PFAM AMP-dependent synthetase and ligase
NicSoilE8_28380	COG1216	Glycosyl transferase, family 2
NicSoilE8_28380	COG1442	glycosyl transferase family 8
NicSoilE8_28390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NicSoilE8_28400	COG0563	adenylate kinase activity
NicSoilE8_28420	COG0200	Binds to the 23S rRNA
NicSoilE8_28430	COG1841	ribosomal large subunit assembly
NicSoilE8_28440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NicSoilE8_28460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NicSoilE8_28470	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NicSoilE8_28480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NicSoilE8_28490	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NicSoilE8_28500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NicSoilE8_28510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NicSoilE8_28520	COG0255	Belongs to the universal ribosomal protein uL29 family
NicSoilE8_28530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NicSoilE8_28540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NicSoilE8_28550	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NicSoilE8_28560	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NicSoilE8_28570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NicSoilE8_28580	COG0089	rRNA binding
NicSoilE8_28590	COG0088	Forms part of the polypeptide exit tunnel
NicSoilE8_28600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NicSoilE8_28610	COG0051	transcription antitermination factor activity, RNA binding
NicSoilE8_28620	COG2723	6-phospho-beta-galactosidase activity
NicSoilE8_28650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NicSoilE8_28660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NicSoilE8_28670	COG0049	tRNA binding
NicSoilE8_28680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NicSoilE8_28690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NicSoilE8_28700	COG0085	RNA polymerase activity
NicSoilE8_28720	COG0183	Belongs to the thiolase family
NicSoilE8_28730	COG0442	prolyl-tRNA aminoacylation
NicSoilE8_28740	COG0222	ribosome binding
NicSoilE8_28750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NicSoilE8_28780	COG0081	regulation of translation
NicSoilE8_28790	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NicSoilE8_28810	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NicSoilE8_28820	COG0436	Aminotransferase
NicSoilE8_28830	COG2197	response regulator
NicSoilE8_28930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NicSoilE8_28950	COG3485	protocatechuate 3,4-dioxygenase
NicSoilE8_28980	COG0745	RESPONSE REGULATOR receiver
NicSoilE8_29000	COG0456	acetyltransferase
NicSoilE8_29010	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NicSoilE8_29040	COG1725	Transcriptional regulator
NicSoilE8_29050	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NicSoilE8_29060	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NicSoilE8_29080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NicSoilE8_29110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NicSoilE8_29130	COG2030	dehydratase
NicSoilE8_29180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NicSoilE8_29200	COG4989	oxidoreductase activity
NicSoilE8_29210	COG0366	Alpha amylase catalytic
NicSoilE8_29220	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_29230	COG1175	transmembrane transport
NicSoilE8_29250	COG1940	carbohydrate kinase activity
NicSoilE8_29270	COG0702	epimerase
NicSoilE8_29330	COG0754	glutathionylspermidine amidase activity
NicSoilE8_29370	COG1175	transmembrane transport
NicSoilE8_29380	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_29420	COG1051	belongs to the nudix hydrolase family
NicSoilE8_29480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NicSoilE8_29510	COG1131	(ABC) transporter
NicSoilE8_29550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NicSoilE8_29570	COG1666	GTP binding
NicSoilE8_29580	COG0501	Belongs to the peptidase M48B family
NicSoilE8_29640	COG0531	amino acid
NicSoilE8_29720	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilE8_29730	COG3835	regulator
NicSoilE8_29740	COG2807	transmembrane transport
NicSoilE8_29750	COG2186	Transcriptional regulator
NicSoilE8_29760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NicSoilE8_29760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NicSoilE8_29780	COG1648	precorrin-2 dehydrogenase activity
NicSoilE8_29780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NicSoilE8_29790	COG2066	Belongs to the glutaminase family
NicSoilE8_29800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilE8_29820	COG1733	regulation of RNA biosynthetic process
NicSoilE8_29850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NicSoilE8_29860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NicSoilE8_29860	COG1116	anion transmembrane transporter activity
NicSoilE8_29880	COG2040	homocysteine
NicSoilE8_29890	COG2895	sulfate adenylyltransferase (ATP) activity
NicSoilE8_29910	COG0175	sulfate reduction
NicSoilE8_29920	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NicSoilE8_29940	COG2860	membrane
NicSoilE8_29980	COG0142	geranyltranstransferase activity
NicSoilE8_30000	COG2226	methyltransferase
NicSoilE8_30010	COG1169	isochorismate synthase
NicSoilE8_30030	COG0765	amino acid transport
NicSoilE8_30050	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NicSoilE8_30070	COG4948	Mandelate Racemase Muconate Lactonizing
NicSoilE8_30100	COG1609	Transcriptional regulator
NicSoilE8_30120	COG1621	beta-fructofuranosidase activity
NicSoilE8_30130	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_30140	COG1175	transmembrane transport
NicSoilE8_30240	COG1404	Belongs to the peptidase S8 family
NicSoilE8_30250	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilE8_30260	COG0022	dehydrogenase e1 component
NicSoilE8_30320	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NicSoilE8_30340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NicSoilE8_30400	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NicSoilE8_30420	COG1134	teichoic acid transport
NicSoilE8_30490	COG1316	TRANSCRIPTIONal
NicSoilE8_30520	COG1597	lipid kinase activity
NicSoilE8_30530	COG2184	nucleotidyltransferase activity
NicSoilE8_30540	COG1024	Enoyl-CoA hydratase
NicSoilE8_30550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NicSoilE8_30560	COG2151	metal-sulfur cluster biosynthetic enzyme
NicSoilE8_30570	COG3396	Phenylacetate-CoA oxygenase
NicSoilE8_30580	COG3460	Phenylacetate-CoA oxygenase
NicSoilE8_30590	COG3396	Phenylacetate-CoA oxygenase
NicSoilE8_30600	COG0463	Glycosyl transferase, family 2
NicSoilE8_30610	COG3979	chitinase
NicSoilE8_30620	COG5002	protein histidine kinase activity
NicSoilE8_30620	COG2205	protein histidine kinase activity
NicSoilE8_30620	COG0784	Response regulator, receiver
NicSoilE8_30630	COG5001	Diguanylate cyclase
NicSoilE8_30630	COG4251	negative regulation of phosphorylation
NicSoilE8_30630	COG3706	GGDEF domain
NicSoilE8_30630	COG2203	Gaf domain
NicSoilE8_30670	COG5002	protein histidine kinase activity
NicSoilE8_30720	COG2050	protein possibly involved in aromatic compounds catabolism
NicSoilE8_30750	COG2801	Transposase and inactivated derivatives
NicSoilE8_30780	COG2030	dehydratase
NicSoilE8_30780	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilE8_30790	COG1216	Glycosyl transferase, family 2
NicSoilE8_30820	COG1250	3-hydroxyacyl-CoA dehydrogenase
NicSoilE8_30830	COG1024	Enoyl-CoA hydratase
NicSoilE8_30840	COG0183	Belongs to the thiolase family
NicSoilE8_30890	COG0488	(ABC) transporter
NicSoilE8_30900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NicSoilE8_30910	COG1121	(ABC) transporter
NicSoilE8_30920	COG0803	Belongs to the bacterial solute-binding protein 9 family
NicSoilE8_30930	COG1266	CAAX protease self-immunity
NicSoilE8_30950	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NicSoilE8_31050	COG0443	Heat shock 70 kDa protein
NicSoilE8_31060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NicSoilE8_31080	COG0785	Cytochrome C biogenesis protein
NicSoilE8_31100	COG0406	alpha-ribazole phosphatase activity
NicSoilE8_31150	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NicSoilE8_31200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NicSoilE8_31210	COG3458	cephalosporin-C deacetylase activity
NicSoilE8_31230	COG2755	lipolytic protein G-D-S-L family
NicSoilE8_31240	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_31250	COG4209	transmembrane transport
NicSoilE8_31260	COG1653	transport
NicSoilE8_31280	COG5578	integral membrane protein
NicSoilE8_31290	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_31300	COG2814	Major facilitator Superfamily
NicSoilE8_31320	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_31330	COG1175	transmembrane transport
NicSoilE8_31370	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_31380	COG1175	transmembrane transport
NicSoilE8_31440	COG4948	Mandelate Racemase Muconate Lactonizing
NicSoilE8_31450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NicSoilE8_31470	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_31480	COG1609	Transcriptional regulator
NicSoilE8_31510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NicSoilE8_31520	COG0640	Transcriptional regulator
NicSoilE8_31540	COG0123	including yeast histone deacetylase and acetoin utilization protein
NicSoilE8_31550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NicSoilE8_31560	COG0569	domain protein
NicSoilE8_31570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NicSoilE8_31580	COG1082	Xylose isomerase domain protein TIM barrel
NicSoilE8_31590	COG0248	Ppx GppA phosphatase
NicSoilE8_31610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NicSoilE8_31610	COG1754	DNA topoisomerase type I activity
NicSoilE8_31630	COG2890	protein-(glutamine-N5) methyltransferase activity
NicSoilE8_31660	COG1054	Belongs to the UPF0176 family
NicSoilE8_31680	COG1111	helicase
NicSoilE8_31680	COG1205	dead DEAH box helicase
NicSoilE8_31810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NicSoilE8_31820	COG1349	DNA-binding transcription factor activity
NicSoilE8_31840	COG0577	efflux transmembrane transporter activity
NicSoilE8_31840	COG1136	(ABC) transporter
NicSoilE8_31860	COG1609	Transcriptional regulator
NicSoilE8_31880	COG1175	transmembrane transport
NicSoilE8_31890	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_31920	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NicSoilE8_31980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NicSoilE8_31990	COG1408	metallophosphoesterase
NicSoilE8_32000	COG1132	(ABC) transporter
NicSoilE8_32010	COG1132	(ABC) transporter
NicSoilE8_32040	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NicSoilE8_32050	COG0151	Belongs to the GarS family
NicSoilE8_32080	COG1301	dicarboxylic acid transport
NicSoilE8_32090	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_32110	COG1953	Uracil, thiamine, allantoin
NicSoilE8_32120	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NicSoilE8_32150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NicSoilE8_32170	COG3608	succinylglutamate desuccinylase aspartoacylase
NicSoilE8_32170	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NicSoilE8_32180	COG2252	PERMEase
NicSoilE8_32190	COG0590	tRNA wobble adenosine to inosine editing
NicSoilE8_32240	COG2233	PERMEase
NicSoilE8_32250	COG1414	Transcriptional regulator
NicSoilE8_32270	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NicSoilE8_32290	COG3257	ureidoglycine aminohydrolase activity
NicSoilE8_32320	COG2318	DinB family
NicSoilE8_32330	COG4585	Histidine kinase
NicSoilE8_32340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NicSoilE8_32390	COG0659	secondary active sulfate transmembrane transporter activity
NicSoilE8_32430	COG0563	adenylate kinase activity
NicSoilE8_32450	COG3401	FG-GAP repeat protein
NicSoilE8_32470	COG0300	oxidoreductase activity
NicSoilE8_32500	COG1569	PIN domain
NicSoilE8_32510	COG3311	Transcriptional regulator
NicSoilE8_32520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NicSoilE8_32570	COG5607	PFAM CHAD domain containing protein
NicSoilE8_32570	COG3025	triphosphatase activity
NicSoilE8_32720	COG0405	Gamma-glutamyltransferase
NicSoilE8_32830	COG1454	alcohol dehydrogenase
NicSoilE8_32840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NicSoilE8_32880	COG2963	transposase activity
NicSoilE8_32900	COG0577	efflux transmembrane transporter activity
NicSoilE8_32900	COG1136	(ABC) transporter
NicSoilE8_32970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NicSoilE8_32980	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_33000	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_33030	COG1653	transport
NicSoilE8_33040	COG1609	Transcriptional regulator
NicSoilE8_33080	COG2963	transposase activity
NicSoilE8_33090	COG3622	Belongs to the hyi family
NicSoilE8_33100	COG2084	Dehydrogenase
NicSoilE8_33110	COG3960	tartronate-semialdehyde synthase activity
NicSoilE8_33120	COG1929	Belongs to the glycerate kinase type-1 family
NicSoilE8_33130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NicSoilE8_33160	COG0745	RESPONSE REGULATOR receiver
NicSoilE8_33200	COG3328	transposase activity
NicSoilE8_33260	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NicSoilE8_33270	COG0671	phosphoesterase, PA-phosphatase related
NicSoilE8_33320	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NicSoilE8_33390	COG0542	response to heat
NicSoilE8_33440	COG3585	molybdate ion transport
NicSoilE8_33480	COG3304	Inner membrane component domain
NicSoilE8_33500	COG0135	phosphoribosylanthranilate isomerase activity
NicSoilE8_33520	COG2076	Multidrug Resistance protein
NicSoilE8_33530	COG2076	Multidrug Resistance protein
NicSoilE8_33560	COG2814	Major facilitator Superfamily
NicSoilE8_33580	COG2813	Specifically methylates the guanine in position
NicSoilE8_33600	COG1473	amidohydrolase
NicSoilE8_33610	COG0477	Major facilitator Superfamily
NicSoilE8_33620	COG2807	transmembrane transport
NicSoilE8_33630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NicSoilE8_33710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NicSoilE8_33740	COG3177	Filamentation induced by cAMP protein fic
NicSoilE8_33840	COG1414	Transcriptional regulator
NicSoilE8_33850	COG1063	alcohol dehydrogenase
NicSoilE8_33860	COG3959	Transketolase, thiamine diphosphate binding domain
NicSoilE8_33870	COG3958	Transketolase
NicSoilE8_33880	COG1105	Belongs to the carbohydrate kinase PfkB family
NicSoilE8_33910	COG0477	Major facilitator Superfamily
NicSoilE8_33920	COG4221	oxidoreductase activity
NicSoilE8_33980	COG0800	Aldolase
NicSoilE8_34000	COG1063	alcohol dehydrogenase
NicSoilE8_34010	COG1063	alcohol dehydrogenase
NicSoilE8_34020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NicSoilE8_34040	COG2140	Oxalate decarboxylase
NicSoilE8_34050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NicSoilE8_34060	COG1737	Transcriptional regulator
NicSoilE8_34080	COG1082	Xylose isomerase domain protein TIM barrel
NicSoilE8_34090	COG1172	Belongs to the binding-protein-dependent transport system permease family
NicSoilE8_34100	COG1129	ABC transporter
NicSoilE8_34110	COG1879	ABC-type sugar transport system periplasmic component
NicSoilE8_34120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NicSoilE8_34130	COG0789	Transcriptional regulator
NicSoilE8_34140	COG0484	heat shock protein binding
NicSoilE8_34150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NicSoilE8_34160	COG0443	Heat shock 70 kDa protein
NicSoilE8_34170	COG3739	integral membrane protein
NicSoilE8_34220	COG3540	Alkaline phosphatase
NicSoilE8_34340	COG0436	Aminotransferase
NicSoilE8_34350	COG1064	alcohol dehydrogenase
NicSoilE8_34390	COG1280	lysine exporter protein (LysE YggA)
NicSoilE8_34410	COG2161	toxin-antitoxin pair type II binding
NicSoilE8_34420	COG2026	Addiction module toxin, RelE StbE family
NicSoilE8_34430	COG0492	ferredoxin-NADP+ reductase activity
NicSoilE8_34440	COG2409	Drug exporters of the RND superfamily
NicSoilE8_34460	COG3415	Transposase
NicSoilE8_34460	COG2801	Transposase and inactivated derivatives
NicSoilE8_34470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NicSoilE8_34480	COG3795	YCII-related domain
NicSoilE8_34490	COG4941	Belongs to the sigma-70 factor family
NicSoilE8_34550	COG1280	lysine exporter protein (LysE YggA)
NicSoilE8_34560	COG1609	Transcriptional regulator
NicSoilE8_34570	COG1957	nucleoside hydrolase
NicSoilE8_34580	COG0477	Major facilitator Superfamily
NicSoilE8_34590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NicSoilE8_34600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NicSoilE8_34620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NicSoilE8_34640	COG0833	amino acid
NicSoilE8_34650	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NicSoilE8_34660	COG3415	Transposase
NicSoilE8_34660	COG2801	Transposase and inactivated derivatives
NicSoilE8_34680	COG2986	histidine ammonia-lyase
NicSoilE8_34740	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NicSoilE8_34760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NicSoilE8_34810	COG1122	ATPase activity
NicSoilE8_34820	COG4721	ABC-type cobalt transport system, permease component
NicSoilE8_34850	COG1320	monovalent cation:proton antiporter activity
NicSoilE8_34860	COG2212	antiporter activity
NicSoilE8_34880	COG0651	ATP synthesis coupled electron transport
NicSoilE8_34890	COG1006	Multisubunit Na H antiporter MnhC subunit
NicSoilE8_34900	COG2111	Na H antiporter
NicSoilE8_34900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NicSoilE8_34930	COG0475	glutathione-regulated potassium exporter activity
NicSoilE8_34950	COG0717	Belongs to the dCTP deaminase family
NicSoilE8_35030	COG0583	DNA-binding transcription factor activity
NicSoilE8_35060	COG1609	Transcriptional regulator
NicSoilE8_35070	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_35120	COG2115	Belongs to the xylose isomerase family
NicSoilE8_35130	COG1070	Carbohydrate kinase
NicSoilE8_35140	COG1609	Transcriptional regulator
NicSoilE8_35170	COG2160	L-arabinose isomerase activity
NicSoilE8_35180	COG2017	converts alpha-aldose to the beta-anomer
NicSoilE8_35190	COG1609	Transcriptional regulator
NicSoilE8_35200	COG3254	rhamnose metabolic process
NicSoilE8_35210	COG4952	isomerase
NicSoilE8_35220	COG3347	Dehydrogenase
NicSoilE8_35220	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_35230	COG1070	Carbohydrate kinase
NicSoilE8_35260	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NicSoilE8_35280	COG3387	PFAM Glycoside hydrolase 15-related
NicSoilE8_35290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilE8_35330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NicSoilE8_35350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NicSoilE8_35390	COG1937	Protein conserved in bacteria
NicSoilE8_35410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NicSoilE8_35440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NicSoilE8_35460	COG1126	abc transporter atp-binding protein
NicSoilE8_35470	COG0765	amino acid transport
NicSoilE8_35500	COG0433	COG0433 Predicted ATPase
NicSoilE8_35540	COG0776	regulation of translation
NicSoilE8_35570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NicSoilE8_35580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NicSoilE8_35590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NicSoilE8_35640	COG1120	ATPase activity
NicSoilE8_35650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NicSoilE8_35660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NicSoilE8_35740	COG3012	SEC-C Motif Domain Protein
NicSoilE8_35770	COG0667	Aldo Keto reductase
NicSoilE8_35810	COG3328	transposase activity
NicSoilE8_35910	COG2186	Transcriptional regulator
NicSoilE8_35930	COG1027	Aspartate ammonia-lyase
NicSoilE8_35950	COG2186	Transcriptional regulator
NicSoilE8_35970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NicSoilE8_35980	COG4221	oxidoreductase activity
NicSoilE8_35990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NicSoilE8_36000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NicSoilE8_36020	COG1522	sequence-specific DNA binding
NicSoilE8_36030	COG1280	lysine exporter protein (LysE YggA)
NicSoilE8_36070	COG1414	Transcriptional regulator
NicSoilE8_36090	COG0477	Major facilitator Superfamily
NicSoilE8_36110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NicSoilE8_36160	COG1760	l-serine dehydratase
NicSoilE8_36220	COG0281	malic enzyme
NicSoilE8_36230	COG1309	transcriptional regulator
NicSoilE8_36280	COG2211	Major facilitator Superfamily
NicSoilE8_36290	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NicSoilE8_36300	COG0477	Major facilitator Superfamily
NicSoilE8_36310	COG0477	Major facilitator Superfamily
NicSoilE8_36320	COG2814	Major facilitator Superfamily
NicSoilE8_36330	COG1846	Transcriptional regulator
NicSoilE8_36380	COG1113	amino acid transport
NicSoilE8_36400	COG0246	Mannitol dehydrogenase
NicSoilE8_36410	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NicSoilE8_36410	COG2213	PTS system mannitol-specific
NicSoilE8_36430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NicSoilE8_36470	COG2267	carboxylic ester hydrolase activity
NicSoilE8_36490	COG1793	dna ligase
NicSoilE8_36530	COG0686	Belongs to the AlaDH PNT family
NicSoilE8_36600	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_36670	COG1309	transcriptional regulator
NicSoilE8_36730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NicSoilE8_36820	COG0508	dehydrogenase complex catalyzes the overall conversion of
NicSoilE8_36830	COG0022	dehydrogenase e1 component
NicSoilE8_36850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NicSoilE8_36860	COG1950	PFAM Membrane protein of
NicSoilE8_36890	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NicSoilE8_36920	COG1607	acyl-coa hydrolase
NicSoilE8_36930	COG4221	oxidoreductase activity
NicSoilE8_36940	COG0477	Major facilitator Superfamily
NicSoilE8_36950	COG1984	allophanate hydrolase subunit 2
NicSoilE8_36960	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NicSoilE8_36970	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NicSoilE8_36980	COG0583	DNA-binding transcription factor activity
NicSoilE8_37000	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NicSoilE8_37010	COG0436	Aminotransferase
NicSoilE8_37080	COG2261	transglycosylase associated protein
NicSoilE8_37100	COG2207	Transcriptional regulator
NicSoilE8_37100	COG3708	Transcriptional regulator
NicSoilE8_37120	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_37150	COG1621	beta-fructofuranosidase activity
NicSoilE8_37170	COG1653	transport
NicSoilE8_37190	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_37200	COG1609	Transcriptional regulator
NicSoilE8_37210	COG1621	beta-fructofuranosidase activity
NicSoilE8_37220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NicSoilE8_37290	COG2365	Tyrosine phosphatase family
NicSoilE8_37300	COG1309	transcriptional regulator
NicSoilE8_37340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NicSoilE8_37370	COG1309	transcriptional regulator
NicSoilE8_37380	COG0515	serine threonine protein kinase
NicSoilE8_37380	COG2815	serine threonine protein kinase
NicSoilE8_37440	COG3387	PFAM Glycoside hydrolase 15-related
NicSoilE8_37480	COG2814	Major facilitator Superfamily
NicSoilE8_37500	COG0243	molybdopterin cofactor binding
NicSoilE8_37530	COG2261	transglycosylase associated protein
NicSoilE8_37540	COG0515	serine threonine protein kinase
NicSoilE8_37550	COG1846	Transcriptional regulator
NicSoilE8_37640	COG2963	transposase activity
NicSoilE8_37780	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NicSoilE8_37790	COG1760	l-serine dehydratase
NicSoilE8_37800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NicSoilE8_37810	COG0509	glycine decarboxylation via glycine cleavage system
NicSoilE8_37820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NicSoilE8_37830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NicSoilE8_37830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NicSoilE8_37850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NicSoilE8_37860	COG1970	mechanosensitive ion channel activity
NicSoilE8_37870	COG2271	Major facilitator Superfamily
NicSoilE8_37880	COG1802	Transcriptional regulator
NicSoilE8_38030	COG3328	transposase activity
NicSoilE8_38110	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NicSoilE8_38250	COG0546	phosphoglycolate phosphatase activity
NicSoilE8_38300	COG1414	Transcriptional regulator
NicSoilE8_38310	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NicSoilE8_38330	COG0183	Belongs to the thiolase family
NicSoilE8_38340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NicSoilE8_38370	COG3485	protocatechuate 3,4-dioxygenase
NicSoilE8_38380	COG3485	protocatechuate 3,4-dioxygenase
NicSoilE8_38390	COG1082	Xylose isomerase domain protein TIM barrel
NicSoilE8_38390	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NicSoilE8_38400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NicSoilE8_38410	COG1414	Transcriptional regulator
NicSoilE8_38420	COG0477	Major facilitator Superfamily
NicSoilE8_38510	COG0646	methionine synthase
NicSoilE8_38510	COG1410	methionine synthase
NicSoilE8_38530	COG1177	transmembrane transport
NicSoilE8_38540	COG4149	molybdate abc transporter
NicSoilE8_38550	COG3842	ATPase activity
NicSoilE8_38580	COG3845	ABC transporter
NicSoilE8_38610	COG2259	Doxx family
NicSoilE8_38640	COG1929	Belongs to the glycerate kinase type-1 family
NicSoilE8_38660	COG0673	inositol 2-dehydrogenase activity
NicSoilE8_38710	COG4211	Belongs to the binding-protein-dependent transport system permease family
NicSoilE8_38720	COG1172	Belongs to the binding-protein-dependent transport system permease family
NicSoilE8_38730	COG1129	ABC transporter
NicSoilE8_38760	COG0693	protein deglycase activity
NicSoilE8_38770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NicSoilE8_38780	COG3386	PFAM SMP-30 Gluconolaconase
NicSoilE8_38790	COG4948	Mandelate Racemase Muconate Lactonizing
NicSoilE8_38820	COG0693	protein deglycase activity
NicSoilE8_38830	COG1461	Dihydroxyacetone kinase
NicSoilE8_38840	COG2376	Dihydroxyacetone kinase
NicSoilE8_38870	COG1172	Belongs to the binding-protein-dependent transport system permease family
NicSoilE8_38880	COG1172	Belongs to the binding-protein-dependent transport system permease family
NicSoilE8_38900	COG2186	Transcriptional regulator
NicSoilE8_38910	COG0800	Aldolase
NicSoilE8_38960	COG1846	Transcriptional regulator
NicSoilE8_38970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NicSoilE8_39010	COG1335	isochorismatase
NicSoilE8_39030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NicSoilE8_39050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NicSoilE8_39060	COG2814	Major facilitator Superfamily
NicSoilE8_39120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NicSoilE8_39140	COG0588	phosphoglycerate mutase activity
NicSoilE8_39160	COG1063	alcohol dehydrogenase
NicSoilE8_39170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NicSoilE8_39180	COG2159	amidohydrolase
NicSoilE8_39200	COG1802	Transcriptional regulator
NicSoilE8_39210	COG1335	isochorismatase
NicSoilE8_39230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NicSoilE8_39240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NicSoilE8_39250	COG1116	anion transmembrane transporter activity
NicSoilE8_39260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NicSoilE8_39330	COG2149	membrane
NicSoilE8_39340	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NicSoilE8_39350	COG1940	carbohydrate kinase activity
NicSoilE8_39370	COG1175	transmembrane transport
NicSoilE8_39380	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_39420	COG0477	Major facilitator Superfamily
NicSoilE8_39450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NicSoilE8_39480	COG2124	cytochrome p450
NicSoilE8_39500	COG1414	Transcriptional regulator
NicSoilE8_39520	COG1012	belongs to the aldehyde dehydrogenase family
NicSoilE8_39530	COG1234	tRNA 3'-trailer cleavage
NicSoilE8_39610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NicSoilE8_39660	COG1309	transcriptional regulator
NicSoilE8_39670	COG1116	anion transmembrane transporter activity
NicSoilE8_39680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NicSoilE8_39690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NicSoilE8_39700	COG1116	anion transmembrane transporter activity
NicSoilE8_39700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NicSoilE8_39710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NicSoilE8_39740	COG3971	2-oxopent-4-enoate hydratase activity
NicSoilE8_39760	COG3384	dioxygenase
NicSoilE8_39780	COG0583	DNA-binding transcription factor activity
NicSoilE8_39840	COG2610	gluconate transmembrane transporter activity
NicSoilE8_39860	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
NicSoilE8_39980	COG1937	Protein conserved in bacteria
NicSoilE8_40090	COG1607	acyl-coa hydrolase
NicSoilE8_40120	COG3958	Transketolase
NicSoilE8_40130	COG3959	Transketolase, thiamine diphosphate binding domain
NicSoilE8_40150	COG1082	Xylose isomerase domain protein TIM barrel
NicSoilE8_40160	COG1028	Short-chain dehydrogenase reductase Sdr
NicSoilE8_40170	COG2376	Dihydroxyacetone kinase
NicSoilE8_40180	COG0698	ribose 5-phosphate isomerase
NicSoilE8_40200	COG0305	Participates in initiation and elongation during chromosome replication
NicSoilE8_40310	COG0359	binds to the 23S rRNA
NicSoilE8_40320	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NicSoilE8_40340	COG0360	Binds together with S18 to 16S ribosomal RNA
NicSoilE8_40350	COG1742	UPF0060 membrane protein
NicSoilE8_40370	COG0640	Transcriptional regulator
NicSoilE8_40390	COG1113	amino acid transport
NicSoilE8_40400	COG1362	aminopeptidase activity
NicSoilE8_40410	COG2197	response regulator
NicSoilE8_40420	COG4585	Histidine kinase
NicSoilE8_40440	COG1131	(ABC) transporter
NicSoilE8_40450	COG1597	lipid kinase activity
NicSoilE8_40470	COG0738	Major facilitator superfamily
NicSoilE8_40490	COG0488	(ABC) transporter
NicSoilE8_40510	COG0768	penicillin binding
NicSoilE8_40520	COG2197	response regulator
NicSoilE8_40530	COG4585	Histidine kinase
NicSoilE8_40550	COG1136	(ABC) transporter
NicSoilE8_40560	COG1733	regulation of RNA biosynthetic process
NicSoilE8_40570	COG2910	NAD(P)H-binding
NicSoilE8_40610	COG0406	alpha-ribazole phosphatase activity
NicSoilE8_40620	COG0617	tRNA 3'-terminal CCA addition
NicSoilE8_40660	COG0492	ferredoxin-NADP+ reductase activity
NicSoilE8_40670	COG3118	belongs to the thioredoxin family
NicSoilE8_40700	COG1192	Involved in chromosome partitioning
NicSoilE8_40710	COG0357	Ribosomal RNA small subunit methyltransferase G
NicSoilE8_40730	COG0706	membrane insertase activity
NicSoilE8_40740	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NicSoilE8_40750	COG0594	ribonuclease P activity
NicSoilE8_40760	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NicSoilE8_40820	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NicSoilE8_40850	COG0686	Belongs to the AlaDH PNT family
NicSoilE8_40890	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NicSoilE8_40960	COG0436	Aminotransferase
NicSoilE8_41000	COG0579	oxidoreductase
NicSoilE8_41030	COG0477	Major facilitator Superfamily
NicSoilE8_41090	COG1960	acyl-CoA dehydrogenase activity
NicSoilE8_41110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NicSoilE8_41120	COG0765	amino acid transport
NicSoilE8_41130	COG0765	amino acid transport
NicSoilE8_41140	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NicSoilE8_41160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NicSoilE8_41170	COG1126	abc transporter atp-binding protein
NicSoilE8_41210	COG1473	amidohydrolase
NicSoilE8_41380	COG1192	Involved in chromosome partitioning
NicSoilE8_41510	COG2963	transposase activity
NicSoilE8_41640	COG1475	DNA binding
NicSoilE8_41820	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
NicSoilE8_41870	COG2267	carboxylic ester hydrolase activity
NicSoilE8_42140	COG2801	Transposase and inactivated derivatives
NicSoilE8_42170	COG2801	Transposase and inactivated derivatives
NicSoilE8_42200	COG2211	Major facilitator Superfamily
NicSoilE8_42540	COG3608	succinylglutamate desuccinylase aspartoacylase
NicSoilE8_42540	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NicSoilE8_42630	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NicSoilE8_42660	COG0179	Fumarylacetoacetate (FAA) hydrolase
NicSoilE8_42760	COG1204	response to ionizing radiation
NicSoilE8_42820	COG1609	Transcriptional regulator
NicSoilE8_42840	COG1175	transmembrane transport
NicSoilE8_42850	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_42920	COG1609	Transcriptional regulator
NicSoilE8_42940	COG1175	transmembrane transport
NicSoilE8_42950	COG0395	ABC-type sugar transport system, permease component
NicSoilE8_43110	COG1609	Transcriptional regulator
NicSoilE8_43120	COG2814	Major facilitator Superfamily
NicSoilE8_43130	COG0657	acetylesterase activity
NicSoilE8_43150	COG2267	carboxylic ester hydrolase activity
NicSoilE8_43200	COG1793	dna ligase
NicSoilE8_43270	COG2135	peptidase activity
NicSoilE8_43330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NicSoilE8_43340	COG1609	Transcriptional regulator
NicSoilE8_43350	COG0747	negative chemotaxis
NicSoilE8_43360	COG0601	transmembrane transport
NicSoilE8_43380	COG4172	Belongs to the ABC transporter superfamily