locus-tag	class	description
NtRootA1_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NtRootA1_00020	COG0592	DNA-directed DNA polymerase activity
NtRootA1_00030	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NtRootA1_00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NtRootA1_00050	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
NtRootA1_00060	COG0187	DNA topoisomerase II activity
NtRootA1_00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NtRootA1_00120	COG1215	transferase activity, transferring glycosyl groups
NtRootA1_00150	COG0705	Rhomboid family
NtRootA1_00150	COG0457	Tetratricopeptide repeat
NtRootA1_00180	COG2818	Glycosylase
NtRootA1_00200	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NtRootA1_00210	COG1595	DNA-templated transcription, initiation
NtRootA1_00240	COG3764	Sortase (surface protein transpeptidase)
NtRootA1_00260	COG0515	serine threonine protein kinase
NtRootA1_00270	COG0515	serine threonine protein kinase
NtRootA1_00280	COG0768	penicillin binding
NtRootA1_00310	COG1716	ATPase activity
NtRootA1_00320	COG1716	ATPase activity
NtRootA1_00330	COG1609	Transcriptional regulator
NtRootA1_00380	COG0346	lactoylglutathione lyase activity
NtRootA1_00410	COG2186	Transcriptional regulator
NtRootA1_00420	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NtRootA1_00430	COG0477	Major facilitator Superfamily
NtRootA1_00440	COG1984	allophanate hydrolase subunit 2
NtRootA1_00450	COG4770	biotin carboxylase activity
NtRootA1_00460	COG0277	FAD linked oxidase domain protein
NtRootA1_00470	COG0385	Bile acid
NtRootA1_00480	COG0659	secondary active sulfate transmembrane transporter activity
NtRootA1_00530	COG0561	phosphatase activity
NtRootA1_00560	COG0584	glycerophosphoryl diester phosphodiesterase
NtRootA1_00570	COG3250	beta-galactosidase activity
NtRootA1_00580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootA1_00590	COG1929	Belongs to the glycerate kinase type-1 family
NtRootA1_00630	COG1082	Xylose isomerase domain protein TIM barrel
NtRootA1_00640	COG2271	Major facilitator Superfamily
NtRootA1_00650	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NtRootA1_00660	COG0693	protein deglycase activity
NtRootA1_00680	COG3655	Transcriptional regulator
NtRootA1_00690	COG2233	PERMEase
NtRootA1_00700	COG0778	Nitroreductase
NtRootA1_00740	COG3104	oligopeptide transport
NtRootA1_00760	COG3340	Belongs to the peptidase S51 family
NtRootA1_00770	COG0425	Belongs to the sulfur carrier protein TusA family
NtRootA1_00770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NtRootA1_00800	COG1597	lipid kinase activity
NtRootA1_00810	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NtRootA1_00830	COG0561	phosphatase activity
NtRootA1_00860	COG1191	sigma factor activity
NtRootA1_00880	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NtRootA1_00890	COG0859	PFAM glycosyl transferase family 9
NtRootA1_00910	COG0438	transferase activity, transferring glycosyl groups
NtRootA1_00920	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NtRootA1_00930	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NtRootA1_00930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NtRootA1_00960	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NtRootA1_00960	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NtRootA1_01110	COG0037	tRNA processing
NtRootA1_01130	COG1609	Transcriptional regulator
NtRootA1_01140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NtRootA1_01150	COG0302	gtp cyclohydrolase
NtRootA1_01170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NtRootA1_01230	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NtRootA1_01250	COG2814	Major facilitator Superfamily
NtRootA1_01310	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NtRootA1_01360	COG0823	Involved in the tonB-independent uptake of proteins
NtRootA1_01360	COG1506	peptidase
NtRootA1_01370	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NtRootA1_01400	COG2376	Dihydroxyacetone kinase
NtRootA1_01410	COG1461	Dihydroxyacetone kinase
NtRootA1_01420	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
NtRootA1_01430	COG3237	CsbD-like
NtRootA1_01520	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NtRootA1_01540	COG0671	phosphoesterase, PA-phosphatase related
NtRootA1_01560	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NtRootA1_01590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NtRootA1_01700	COG1609	Transcriptional regulator
NtRootA1_01730	COG0436	Aminotransferase
NtRootA1_01740	COG0586	Pfam SNARE associated Golgi protein
NtRootA1_01750	COG0831	urea catabolic process
NtRootA1_01760	COG0832	Belongs to the urease beta subunit family
NtRootA1_01770	COG0804	urea catabolic process
NtRootA1_01780	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NtRootA1_01790	COG0830	nickel cation binding
NtRootA1_01800	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NtRootA1_01810	COG0829	nickel cation binding
NtRootA1_01820	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
NtRootA1_01890	COG0656	L-ascorbic acid biosynthetic process
NtRootA1_01910	COG0667	Aldo Keto reductase
NtRootA1_01920	COG0656	L-ascorbic acid biosynthetic process
NtRootA1_01940	COG3360	Dodecin
NtRootA1_01950	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_01970	COG2186	Transcriptional regulator
NtRootA1_01980	COG2267	carboxylic ester hydrolase activity
NtRootA1_02000	COG2084	Dehydrogenase
NtRootA1_02010	COG2610	gluconate transmembrane transporter activity
NtRootA1_02130	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NtRootA1_02140	COG0076	glutamate decarboxylase activity
NtRootA1_02210	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_02250	COG0346	lactoylglutathione lyase activity
NtRootA1_02270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NtRootA1_02280	COG0477	Major facilitator Superfamily
NtRootA1_02290	COG2890	protein-(glutamine-N5) methyltransferase activity
NtRootA1_02320	COG1793	dna ligase
NtRootA1_02320	COG3285	dna ligase
NtRootA1_02330	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NtRootA1_02340	COG0395	ABC-type sugar transport system, permease component
NtRootA1_02350	COG1175	transmembrane transport
NtRootA1_02380	COG2188	Transcriptional regulator
NtRootA1_02480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NtRootA1_02490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NtRootA1_02490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NtRootA1_02490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NtRootA1_02500	COG1105	Belongs to the carbohydrate kinase PfkB family
NtRootA1_02510	COG1349	DNA-binding transcription factor activity
NtRootA1_02570	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NtRootA1_02620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NtRootA1_02670	COG1846	Transcriptional regulator
NtRootA1_02720	COG0142	geranyltranstransferase activity
NtRootA1_02730	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NtRootA1_02770	COG0583	DNA-binding transcription factor activity
NtRootA1_02830	COG2186	Transcriptional regulator
NtRootA1_02860	COG0129	dihydroxy-acid dehydratase activity
NtRootA1_02870	COG0028	Belongs to the TPP enzyme family
NtRootA1_02920	COG1802	Transcriptional regulator
NtRootA1_02940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NtRootA1_02960	COG1126	abc transporter atp-binding protein
NtRootA1_02970	COG0765	amino acid transport
NtRootA1_02980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA1_03000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NtRootA1_03010	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_03020	COG0473	3-isopropylmalate dehydrogenase activity
NtRootA1_03080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootA1_03090	COG4172	Belongs to the ABC transporter superfamily
NtRootA1_03100	COG0583	DNA-binding transcription factor activity
NtRootA1_03130	COG0673	inositol 2-dehydrogenase activity
NtRootA1_03180	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NtRootA1_03190	COG1984	allophanate hydrolase subunit 2
NtRootA1_03200	COG2733	membrane
NtRootA1_03270	COG4122	O-methyltransferase activity
NtRootA1_03280	COG0454	-acetyltransferase
NtRootA1_03280	COG0456	acetyltransferase
NtRootA1_03300	COG0583	DNA-binding transcription factor activity
NtRootA1_03320	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_03340	COG1131	(ABC) transporter
NtRootA1_03350	COG3559	Exporter of polyketide antibiotics
NtRootA1_03370	COG1733	regulation of RNA biosynthetic process
NtRootA1_03410	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NtRootA1_03450	COG2902	Dehydrogenase
NtRootA1_03480	COG2252	PERMEase
NtRootA1_03540	COG3848	Pyruvate phosphate dikinase
NtRootA1_03540	COG0574	Belongs to the PEP-utilizing enzyme family
NtRootA1_03600	COG3655	Transcriptional regulator
NtRootA1_03630	COG3559	Exporter of polyketide antibiotics
NtRootA1_03640	COG1131	(ABC) transporter
NtRootA1_03660	COG0395	ABC-type sugar transport system, permease component
NtRootA1_03670	COG1175	transmembrane transport
NtRootA1_03680	COG1285	pathogenesis
NtRootA1_03730	COG1302	Protein conserved in bacteria
NtRootA1_03810	COG1653	transport
NtRootA1_03820	COG1175	transmembrane transport
NtRootA1_03830	COG0395	ABC-type sugar transport system, permease component
NtRootA1_03840	COG1609	Transcriptional regulator
NtRootA1_03880	COG2197	response regulator
NtRootA1_03890	COG4585	Histidine kinase
NtRootA1_03920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NtRootA1_03930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NtRootA1_03940	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NtRootA1_04000	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_04010	COG0395	ABC-type sugar transport system, permease component
NtRootA1_04020	COG1175	transmembrane transport
NtRootA1_04040	COG3684	Belongs to the aldolase LacD family
NtRootA1_04060	COG0673	inositol 2-dehydrogenase activity
NtRootA1_04070	COG1349	DNA-binding transcription factor activity
NtRootA1_04140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NtRootA1_04160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NtRootA1_04170	COG0303	'Molybdopterin
NtRootA1_04180	COG1063	alcohol dehydrogenase
NtRootA1_04210	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NtRootA1_04220	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NtRootA1_04230	COG3404	Formiminotransferase-cyclodeaminase
NtRootA1_04260	COG1802	Transcriptional regulator
NtRootA1_04270	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NtRootA1_04300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NtRootA1_04310	COG2197	response regulator
NtRootA1_04360	COG0415	Belongs to the DNA photolyase family
NtRootA1_04420	COG1024	Enoyl-CoA hydratase
NtRootA1_04460	COG1131	(ABC) transporter
NtRootA1_04520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NtRootA1_04530	COG1960	acyl-CoA dehydrogenase activity
NtRootA1_04560	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_04620	COG0789	Transcriptional regulator
NtRootA1_04630	COG1695	Transcriptional regulator
NtRootA1_04650	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_04660	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NtRootA1_04680	COG0531	amino acid
NtRootA1_04690	COG2186	Transcriptional regulator
NtRootA1_04710	COG1609	Transcriptional regulator
NtRootA1_04740	COG0395	ABC-type sugar transport system, permease component
NtRootA1_04760	COG0673	inositol 2-dehydrogenase activity
NtRootA1_04780	COG1904	glucuronate isomerase
NtRootA1_04790	COG0246	Mannitol dehydrogenase
NtRootA1_04800	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootA1_04810	COG3265	gluconokinase activity
NtRootA1_04820	COG4213	ABC transporter substrate-binding protein
NtRootA1_04830	COG1129	ABC transporter
NtRootA1_04840	COG4214	carbohydrate transport
NtRootA1_04850	COG1609	Transcriptional regulator
NtRootA1_04860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NtRootA1_04910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NtRootA1_04910	COG0357	Ribosomal RNA small subunit methyltransferase G
NtRootA1_05010	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NtRootA1_05020	COG0477	Major facilitator Superfamily
NtRootA1_05060	COG3321	synthase
NtRootA1_05060	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_05060	COG0604	alcohol dehydrogenase
NtRootA1_05070	COG0488	(ABC) transporter
NtRootA1_05090	COG1309	transcriptional regulator
NtRootA1_05110	COG2814	Major facilitator Superfamily
NtRootA1_05120	COG2186	Transcriptional regulator
NtRootA1_05160	COG0765	amino acid transport
NtRootA1_05170	COG1126	abc transporter atp-binding protein
NtRootA1_05220	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_05240	COG0477	Major facilitator Superfamily
NtRootA1_05320	COG2197	response regulator
NtRootA1_05390	COG0765	amino acid transport
NtRootA1_05400	COG1126	abc transporter atp-binding protein
NtRootA1_05410	COG0673	inositol 2-dehydrogenase activity
NtRootA1_05450	COG1621	beta-fructofuranosidase activity
NtRootA1_05470	COG0395	ABC-type sugar transport system, permease component
NtRootA1_05480	COG4209	transmembrane transport
NtRootA1_05490	COG1609	Transcriptional regulator
NtRootA1_05520	COG1832	CoA-binding protein
NtRootA1_05550	COG2315	Protein conserved in bacteria
NtRootA1_05570	COG1653	transport
NtRootA1_05580	COG1175	transmembrane transport
NtRootA1_05590	COG0395	ABC-type sugar transport system, permease component
NtRootA1_05680	COG2368	4-hydroxyphenylacetate
NtRootA1_05750	COG3706	GGDEF domain
NtRootA1_05790	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NtRootA1_05800	COG0047	phosphoribosylformylglycinamidine synthase activity
NtRootA1_05910	COG0024	Methionine aminopeptidase
NtRootA1_05920	COG1846	Transcriptional regulator
NtRootA1_06010	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_06070	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NtRootA1_06090	COG1876	peptidase activity
NtRootA1_06100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NtRootA1_06100	COG3323	Protein of unknown function (DUF1653)
NtRootA1_06130	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_06170	COG1196	nuclear chromosome segregation
NtRootA1_06170	COG0739	heme binding
NtRootA1_06170	COG0741	lytic transglycosylase activity
NtRootA1_06180	COG0386	Belongs to the glutathione peroxidase family
NtRootA1_06190	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NtRootA1_06240	COG1309	transcriptional regulator
NtRootA1_06250	COG2271	Major facilitator Superfamily
NtRootA1_06260	COG0494	nUDIX hydrolase
NtRootA1_06270	COG1309	transcriptional regulator
NtRootA1_06320	COG1609	Transcriptional regulator
NtRootA1_06340	COG1175	transmembrane transport
NtRootA1_06350	COG0395	ABC-type sugar transport system, permease component
NtRootA1_06380	COG0438	transferase activity, transferring glycosyl groups
NtRootA1_06410	COG0589	response to stress
NtRootA1_06450	COG3290	protein histidine kinase activity
NtRootA1_06460	COG4565	transcriptional regulatory protein
NtRootA1_06480	COG4702	Belongs to the UPF0303 family
NtRootA1_06500	COG0823	Involved in the tonB-independent uptake of proteins
NtRootA1_06520	COG0673	inositol 2-dehydrogenase activity
NtRootA1_06530	COG0673	inositol 2-dehydrogenase activity
NtRootA1_06550	COG0395	ABC-type sugar transport system, permease component
NtRootA1_06570	COG2182	Extracellular solute-binding protein
NtRootA1_06580	COG0673	inositol 2-dehydrogenase activity
NtRootA1_06600	COG1846	Transcriptional regulator
NtRootA1_06600	COG1940	carbohydrate kinase activity
NtRootA1_06610	COG2807	transmembrane transport
NtRootA1_06620	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NtRootA1_06640	COG1476	TRANSCRIPTIONal
NtRootA1_06660	COG1309	transcriptional regulator
NtRootA1_06680	COG0351	phosphomethylpyrimidine kinase
NtRootA1_06700	COG2205	protein histidine kinase activity
NtRootA1_06710	COG0745	RESPONSE REGULATOR receiver
NtRootA1_06720	COG0477	Major facilitator Superfamily
NtRootA1_06750	COG0343	queuine tRNA-ribosyltransferase activity
NtRootA1_06810	COG3842	ATPase activity
NtRootA1_06980	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NtRootA1_07000	COG0586	Pfam SNARE associated Golgi protein
NtRootA1_07030	COG0564	pseudouridine synthase activity
NtRootA1_07090	COG2364	Membrane
NtRootA1_07100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NtRootA1_07110	COG1201	RNA secondary structure unwinding
NtRootA1_07220	COG0438	transferase activity, transferring glycosyl groups
NtRootA1_07250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NtRootA1_07290	COG0789	Transcriptional regulator
NtRootA1_07310	COG2205	protein histidine kinase activity
NtRootA1_07320	COG0745	RESPONSE REGULATOR receiver
NtRootA1_07340	COG2062	phosphohistidine phosphatase, SixA
NtRootA1_07360	COG0730	response to heat
NtRootA1_07370	COG0402	S-adenosylhomocysteine deaminase activity
NtRootA1_07380	COG2814	Major facilitator Superfamily
NtRootA1_07410	COG0583	DNA-binding transcription factor activity
NtRootA1_07420	COG0697	spore germination
NtRootA1_07440	COG1309	transcriptional regulator
NtRootA1_07450	COG1511	domain protein
NtRootA1_07480	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
NtRootA1_07490	COG1940	carbohydrate kinase activity
NtRootA1_07510	COG4608	Belongs to the ABC transporter superfamily
NtRootA1_07520	COG0444	Belongs to the ABC transporter superfamily
NtRootA1_07540	COG0747	negative chemotaxis
NtRootA1_07550	COG2188	Transcriptional regulator
NtRootA1_07560	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
NtRootA1_07610	COG0514	ATP-dependent DNA helicase (RecQ)
NtRootA1_07620	COG0477	Major facilitator Superfamily
NtRootA1_07630	COG1505	serine-type exopeptidase activity
NtRootA1_07660	COG1113	amino acid transport
NtRootA1_07690	COG3321	synthase
NtRootA1_07690	COG0604	alcohol dehydrogenase
NtRootA1_07690	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_07710	COG1966	Carbon starvation protein
NtRootA1_07750	COG0656	L-ascorbic acid biosynthetic process
NtRootA1_07820	COG0492	ferredoxin-NADP+ reductase activity
NtRootA1_07870	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NtRootA1_07880	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NtRootA1_07920	COG0588	phosphoglycerate mutase activity
NtRootA1_07980	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NtRootA1_07990	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NtRootA1_08010	COG0215	cysteine-tRNA ligase activity
NtRootA1_08080	COG0366	Alpha amylase catalytic
NtRootA1_08100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NtRootA1_08140	COG1609	Transcriptional regulator
NtRootA1_08150	COG0366	Alpha amylase catalytic
NtRootA1_08180	COG3833	ABC-type maltose transport systems, permease component
NtRootA1_08190	COG0366	Alpha amylase catalytic
NtRootA1_08200	COG0277	FAD linked oxidase domain protein
NtRootA1_08230	COG0402	S-adenosylhomocysteine deaminase activity
NtRootA1_08240	COG4608	Belongs to the ABC transporter superfamily
NtRootA1_08250	COG0444	Belongs to the ABC transporter superfamily
NtRootA1_08260	COG0601	transmembrane transport
NtRootA1_08280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootA1_08290	COG0402	S-adenosylhomocysteine deaminase activity
NtRootA1_08330	COG3842	ATPase activity
NtRootA1_08350	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NtRootA1_08390	COG3118	belongs to the thioredoxin family
NtRootA1_08400	COG0475	glutathione-regulated potassium exporter activity
NtRootA1_08420	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NtRootA1_08430	COG0588	phosphoglycerate mutase activity
NtRootA1_08440	COG1252	NADH dehydrogenase
NtRootA1_08490	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_08510	COG1960	acyl-CoA dehydrogenase activity
NtRootA1_08560	COG0579	oxidoreductase
NtRootA1_08630	COG2957	Belongs to the agmatine deiminase family
NtRootA1_08700	COG0477	Major facilitator Superfamily
NtRootA1_08720	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NtRootA1_08720	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NtRootA1_08730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NtRootA1_08740	COG0509	glycine decarboxylation via glycine cleavage system
NtRootA1_08750	COG1760	l-serine dehydratase
NtRootA1_08760	COG1864	DNA RNA non-specific endonuclease
NtRootA1_08760	COG3591	Belongs to the peptidase S1B family
NtRootA1_08800	COG0577	efflux transmembrane transporter activity
NtRootA1_08800	COG1136	(ABC) transporter
NtRootA1_08850	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NtRootA1_08890	COG0459	protein refolding
NtRootA1_08900	COG0328	RNA-DNA hybrid ribonuclease activity
NtRootA1_08920	COG2205	protein histidine kinase activity
NtRootA1_08930	COG0745	RESPONSE REGULATOR receiver
NtRootA1_08950	COG0583	DNA-binding transcription factor activity
NtRootA1_08970	COG2132	Multicopper oxidase
NtRootA1_09020	COG1278	Cold shock
NtRootA1_09060	COG0739	heme binding
NtRootA1_09070	COG0791	NLP P60 protein
NtRootA1_09070	COG1388	LysM domain
NtRootA1_09070	COG3103	Sh3 type 3 domain protein
NtRootA1_09100	COG0746	molybdenum cofactor guanylyltransferase activity
NtRootA1_09130	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NtRootA1_09150	COG1126	abc transporter atp-binding protein
NtRootA1_09160	COG0765	amino acid transport
NtRootA1_09170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA1_09200	COG0488	(ABC) transporter
NtRootA1_09210	COG1132	(ABC) transporter
NtRootA1_09220	COG0494	nUDIX hydrolase
NtRootA1_09270	COG0483	inositol monophosphate 1-phosphatase activity
NtRootA1_09300	COG0045	succinate-CoA ligase (ADP-forming) activity
NtRootA1_09320	COG1942	4-Oxalocrotonate Tautomerase
NtRootA1_09330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NtRootA1_09350	COG3962	Belongs to the TPP enzyme family
NtRootA1_09380	COG0673	inositol 2-dehydrogenase activity
NtRootA1_09390	COG1082	Xylose isomerase domain protein TIM barrel
NtRootA1_09400	COG3718	enzyme involved in inositol metabolism
NtRootA1_09410	COG2188	Transcriptional regulator
NtRootA1_09430	COG1172	Belongs to the binding-protein-dependent transport system permease family
NtRootA1_09460	COG0673	inositol 2-dehydrogenase activity
NtRootA1_09480	COG0673	inositol 2-dehydrogenase activity
NtRootA1_09500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NtRootA1_09500	COG0519	Catalyzes the synthesis of GMP from XMP
NtRootA1_09580	COG1396	sequence-specific DNA binding
NtRootA1_09620	COG0028	Belongs to the TPP enzyme family
NtRootA1_09680	COG3142	Participates in the control of copper homeostasis
NtRootA1_09690	COG1621	beta-fructofuranosidase activity
NtRootA1_09710	COG1653	transport
NtRootA1_09730	COG0395	ABC-type sugar transport system, permease component
NtRootA1_09750	COG1609	Transcriptional regulator
NtRootA1_09760	COG1621	beta-fructofuranosidase activity
NtRootA1_09820	COG1401	restriction endodeoxyribonuclease activity
NtRootA1_09850	COG5002	protein histidine kinase activity
NtRootA1_09860	COG0745	RESPONSE REGULATOR receiver
NtRootA1_09870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NtRootA1_09900	COG0604	alcohol dehydrogenase
NtRootA1_09920	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_09930	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_09950	COG1024	Enoyl-CoA hydratase
NtRootA1_09960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NtRootA1_09980	COG0477	Major facilitator Superfamily
NtRootA1_09990	COG1396	sequence-specific DNA binding
NtRootA1_10020	COG2124	cytochrome p450
NtRootA1_10030	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NtRootA1_10050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NtRootA1_10070	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NtRootA1_10090	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_10130	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NtRootA1_10140	COG1902	pentaerythritol trinitrate reductase activity
NtRootA1_10170	COG2376	Dihydroxyacetone kinase
NtRootA1_10180	COG0698	ribose 5-phosphate isomerase
NtRootA1_10190	COG1250	3-hydroxyacyl-CoA dehydrogenase
NtRootA1_10260	COG2183	response to ionizing radiation
NtRootA1_10290	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NtRootA1_10310	COG1254	Belongs to the acylphosphatase family
NtRootA1_10320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NtRootA1_10330	COG2186	Transcriptional regulator
NtRootA1_10340	COG0477	Major facilitator Superfamily
NtRootA1_10360	COG0640	Transcriptional regulator
NtRootA1_10370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NtRootA1_10390	COG4209	transmembrane transport
NtRootA1_10400	COG0395	ABC-type sugar transport system, permease component
NtRootA1_10480	COG1472	Belongs to the glycosyl hydrolase 3 family
NtRootA1_10490	COG0673	inositol 2-dehydrogenase activity
NtRootA1_10520	COG1609	Transcriptional regulator
NtRootA1_10550	COG0477	Major facilitator Superfamily
NtRootA1_10570	COG1937	Protein conserved in bacteria
NtRootA1_10590	COG0730	response to heat
NtRootA1_10610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NtRootA1_10620	COG0640	Transcriptional regulator
NtRootA1_10650	COG3973	AAA domain
NtRootA1_10660	COG0604	alcohol dehydrogenase
NtRootA1_10660	COG3321	synthase
NtRootA1_10680	COG1309	transcriptional regulator
NtRootA1_10720	COG2217	Heavy metal translocating P-type atpase
NtRootA1_10770	COG1131	(ABC) transporter
NtRootA1_10790	COG0640	Transcriptional regulator
NtRootA1_10960	COG1401	restriction endodeoxyribonuclease activity
NtRootA1_11100	COG2072	flavoprotein involved in K transport
NtRootA1_11120	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_11150	COG1278	Cold shock
NtRootA1_11200	COG1846	Transcriptional regulator
NtRootA1_11260	COG2755	lipolytic protein G-D-S-L family
NtRootA1_11270	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NtRootA1_11330	COG0789	Transcriptional regulator
NtRootA1_11340	COG0071	Belongs to the small heat shock protein (HSP20) family
NtRootA1_11350	COG0484	heat shock protein binding
NtRootA1_11380	COG2268	Band 7 protein
NtRootA1_11440	COG0477	Major facilitator Superfamily
NtRootA1_11450	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NtRootA1_11470	COG0138	bifunctional purine biosynthesis protein purh
NtRootA1_11490	COG2838	Isocitrate dehydrogenase
NtRootA1_11520	COG0673	inositol 2-dehydrogenase activity
NtRootA1_11550	COG0577	efflux transmembrane transporter activity
NtRootA1_11550	COG1136	(ABC) transporter
NtRootA1_11560	COG1136	(ABC) transporter
NtRootA1_11560	COG0577	efflux transmembrane transporter activity
NtRootA1_11570	COG1136	(ABC) transporter
NtRootA1_11600	COG4213	ABC transporter substrate-binding protein
NtRootA1_11620	COG1129	ABC transporter
NtRootA1_11640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NtRootA1_11660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NtRootA1_11670	COG0531	amino acid
NtRootA1_11730	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NtRootA1_11750	COG2197	response regulator
NtRootA1_11770	COG1131	(ABC) transporter
NtRootA1_11810	COG0708	Exodeoxyribonuclease III
NtRootA1_11820	COG0180	Tryptophanyl-tRNA synthetase
NtRootA1_11910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NtRootA1_11940	COG2009	succinate dehydrogenase
NtRootA1_11960	COG1473	amidohydrolase
NtRootA1_11960	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NtRootA1_11970	COG1846	Transcriptional regulator
NtRootA1_11980	COG1764	response to oxidative stress
NtRootA1_11990	COG2130	NADP-dependent
NtRootA1_12000	COG1744	ABC transporter substrate-binding protein PnrA-like
NtRootA1_12010	COG3845	ABC transporter
NtRootA1_12020	COG4603	Belongs to the binding-protein-dependent transport system permease family
NtRootA1_12030	COG1079	Belongs to the binding-protein-dependent transport system permease family
NtRootA1_12070	COG0586	Pfam SNARE associated Golgi protein
NtRootA1_12080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NtRootA1_12100	COG0148	phosphopyruvate hydratase activity
NtRootA1_12160	COG1252	NADH dehydrogenase
NtRootA1_12240	COG0183	Belongs to the thiolase family
NtRootA1_12250	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NtRootA1_12270	COG2017	converts alpha-aldose to the beta-anomer
NtRootA1_12290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NtRootA1_12310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NtRootA1_12330	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NtRootA1_12380	COG0604	alcohol dehydrogenase
NtRootA1_12400	COG2271	Major facilitator Superfamily
NtRootA1_12450	COG1228	amidohydrolase
NtRootA1_12460	COG1331	Highly conserved protein containing a thioredoxin domain
NtRootA1_12480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NtRootA1_12490	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NtRootA1_12550	COG0114	fumarate hydratase activity
NtRootA1_12580	COG1494	fructose-1,6-bisphosphatase
NtRootA1_12720	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NtRootA1_12730	COG1376	ErfK ybiS ycfS ynhG family protein
NtRootA1_12750	COG1357	PFAM Pentapeptide repeats (8 copies)
NtRootA1_12850	COG0714	Associated with various cellular activities
NtRootA1_12860	COG0084	hydrolase, TatD family'
NtRootA1_12870	COG3583	domain protein
NtRootA1_12880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NtRootA1_12890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NtRootA1_12900	COG0488	(ABC) transporter
NtRootA1_12920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NtRootA1_12940	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NtRootA1_12950	COG0193	aminoacyl-tRNA hydrolase activity
NtRootA1_13000	COG0822	iron-sulfur transferase activity
NtRootA1_13010	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NtRootA1_13040	COG0702	epimerase
NtRootA1_13060	COG1988	membrane-bound metal-dependent
NtRootA1_13080	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NtRootA1_13210	COG2814	Major facilitator Superfamily
NtRootA1_13240	COG0583	DNA-binding transcription factor activity
NtRootA1_13260	COG3395	kinase activity
NtRootA1_13270	COG0235	Class ii aldolase
NtRootA1_13300	COG2146	nitrite reductase [NAD(P)H] activity
NtRootA1_13300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NtRootA1_13320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NtRootA1_13330	COG1621	beta-fructofuranosidase activity
NtRootA1_13410	COG0243	molybdopterin cofactor binding
NtRootA1_13420	COG2223	nitrite transmembrane transporter activity
NtRootA1_13430	COG0477	Major facilitator Superfamily
NtRootA1_13440	COG4770	biotin carboxylase activity
NtRootA1_13450	COG0424	maF-like protein
NtRootA1_13460	COG2409	Drug exporters of the RND superfamily
NtRootA1_13480	COG0393	Putative heavy-metal-binding
NtRootA1_13490	COG1823	symporter activity
NtRootA1_13510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NtRootA1_13520	COG0300	oxidoreductase activity
NtRootA1_13530	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NtRootA1_13530	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NtRootA1_13590	COG0714	Associated with various cellular activities
NtRootA1_13630	COG0631	protein serine/threonine phosphatase activity
NtRootA1_13670	COG1674	ftsk spoiiie
NtRootA1_13680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NtRootA1_13690	COG0483	inositol monophosphate 1-phosphatase activity
NtRootA1_13710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA1_13730	COG0251	oxidation-reduction process
NtRootA1_13740	COG4565	transcriptional regulatory protein
NtRootA1_13760	COG2851	Citrate transporter
NtRootA1_13770	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NtRootA1_13780	COG0154	amidase activity
NtRootA1_13790	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NtRootA1_13820	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NtRootA1_13830	COG4209	transmembrane transport
NtRootA1_13840	COG0395	ABC-type sugar transport system, permease component
NtRootA1_13860	COG1609	Transcriptional regulator
NtRootA1_13870	COG0673	inositol 2-dehydrogenase activity
NtRootA1_13890	COG1063	alcohol dehydrogenase
NtRootA1_13900	COG0156	8-amino-7-oxononanoate synthase activity
NtRootA1_13920	COG1228	amidohydrolase
NtRootA1_13970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NtRootA1_13980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NtRootA1_13990	COG1940	carbohydrate kinase activity
NtRootA1_14030	COG0588	phosphoglycerate mutase activity
NtRootA1_14070	COG2873	o-acetylhomoserine
NtRootA1_14080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NtRootA1_14150	COG0423	glycine-tRNA ligase activity
NtRootA1_14210	COG0358	DNA primase activity
NtRootA1_14230	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NtRootA1_14240	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NtRootA1_14260	COG2814	Major facilitator Superfamily
NtRootA1_14280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NtRootA1_14350	COG0052	Belongs to the universal ribosomal protein uS2 family
NtRootA1_14360	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NtRootA1_14370	COG0528	UMP kinase activity
NtRootA1_14380	COG0233	cytoplasmic translational termination
NtRootA1_14390	COG0575	Belongs to the CDS family
NtRootA1_14420	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NtRootA1_14450	COG3275	phosphorelay sensor kinase activity
NtRootA1_14470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NtRootA1_14480	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NtRootA1_14480	COG1796	DNA polymerase
NtRootA1_14530	COG1522	sequence-specific DNA binding
NtRootA1_14550	COG0022	dehydrogenase e1 component
NtRootA1_14560	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA1_14570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NtRootA1_14610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NtRootA1_14630	COG1960	acyl-CoA dehydrogenase activity
NtRootA1_14680	COG0673	inositol 2-dehydrogenase activity
NtRootA1_14710	COG0673	inositol 2-dehydrogenase activity
NtRootA1_14730	COG1175	transmembrane transport
NtRootA1_14740	COG1653	transport
NtRootA1_14770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NtRootA1_14780	COG0750	zinc metalloprotease
NtRootA1_14800	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NtRootA1_14850	COG0442	prolyl-tRNA aminoacylation
NtRootA1_14870	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
NtRootA1_14900	COG0779	Required for maturation of 30S ribosomal subunits
NtRootA1_14910	COG0195	Participates in both transcription termination and antitermination
NtRootA1_14950	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NtRootA1_14950	COG0481	GTPase activity
NtRootA1_14960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NtRootA1_14970	COG0590	tRNA wobble adenosine to inosine editing
NtRootA1_14990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NtRootA1_15030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NtRootA1_15040	COG1185	polyribonucleotide nucleotidyltransferase activity
NtRootA1_15050	COG0612	Peptidase, M16
NtRootA1_15090	COG0745	RESPONSE REGULATOR receiver
NtRootA1_15100	COG2205	protein histidine kinase activity
NtRootA1_15140	COG0521	Mo-molybdopterin cofactor biosynthetic process
NtRootA1_15160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NtRootA1_15210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NtRootA1_15220	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NtRootA1_15230	COG1674	ftsk spoiiie
NtRootA1_15250	COG1546	Belongs to the CinA family
NtRootA1_15250	COG1058	Belongs to the CinA family
NtRootA1_15260	COG1396	sequence-specific DNA binding
NtRootA1_15290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NtRootA1_15300	COG2137	regulation of response to DNA damage stimulus
NtRootA1_15310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NtRootA1_15320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NtRootA1_15330	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NtRootA1_15340	COG2813	Specifically methylates the guanine in position
NtRootA1_15350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NtRootA1_15370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NtRootA1_15380	COG1388	LysM domain
NtRootA1_15390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NtRootA1_15400	COG0131	Imidazoleglycerol-phosphate dehydratase
NtRootA1_15410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NtRootA1_15430	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NtRootA1_15480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NtRootA1_15490	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NtRootA1_15500	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NtRootA1_15520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NtRootA1_15540	COG2814	Major facilitator Superfamily
NtRootA1_15610	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NtRootA1_15620	COG0072	phenylalanine-tRNA ligase activity
NtRootA1_15620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NtRootA1_15650	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NtRootA1_15660	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NtRootA1_15670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NtRootA1_15680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NtRootA1_15690	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NtRootA1_15700	COG1438	arginine binding
NtRootA1_15710	COG0137	argininosuccinate synthase activity
NtRootA1_15720	COG0165	Argininosuccinate lyase
NtRootA1_15750	COG2094	Belongs to the DNA glycosylase MPG family
NtRootA1_15770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NtRootA1_15800	COG0647	UMP catabolic process
NtRootA1_15830	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NtRootA1_15840	COG0497	DNA recombination
NtRootA1_15850	COG0504	CTP synthase activity
NtRootA1_15910	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NtRootA1_15920	COG2079	MmgE PrpD family protein
NtRootA1_15970	COG3290	protein histidine kinase activity
NtRootA1_15980	COG1301	dicarboxylic acid transport
NtRootA1_16000	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NtRootA1_16010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NtRootA1_16040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NtRootA1_16060	COG1160	GTP binding
NtRootA1_16090	COG2814	Major facilitator Superfamily
NtRootA1_16110	COG0509	glycine decarboxylation via glycine cleavage system
NtRootA1_16120	COG1716	ATPase activity
NtRootA1_16170	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NtRootA1_16190	COG1940	carbohydrate kinase activity
NtRootA1_16240	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NtRootA1_16250	COG0515	serine threonine protein kinase
NtRootA1_16250	COG2815	serine threonine protein kinase
NtRootA1_16260	COG1388	LysM domain
NtRootA1_16260	COG3942	CHAP domain
NtRootA1_16290	COG0142	geranyltranstransferase activity
NtRootA1_16320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NtRootA1_16340	COG2001	Belongs to the MraZ family
NtRootA1_16350	COG0275	rRNA processing
NtRootA1_16370	COG0768	penicillin binding
NtRootA1_16390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NtRootA1_16400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NtRootA1_16410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NtRootA1_16420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NtRootA1_16440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NtRootA1_16450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NtRootA1_16470	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NtRootA1_16480	COG1496	oxidoreductase activity
NtRootA1_16490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NtRootA1_16500	COG1799	cell septum assembly
NtRootA1_16530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NtRootA1_16580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NtRootA1_16590	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NtRootA1_16600	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_16640	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NtRootA1_16650	COG0174	glutamine synthetase
NtRootA1_16660	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NtRootA1_16730	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NtRootA1_16740	COG0321	lipoyl(octanoyl) transferase activity
NtRootA1_16790	COG4946	Tricorn protease homolog
NtRootA1_16790	COG0793	Belongs to the peptidase S41A family
NtRootA1_16800	COG1764	response to oxidative stress
NtRootA1_16820	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA1_16830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NtRootA1_16840	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NtRootA1_16880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NtRootA1_16900	COG0187	DNA topoisomerase II activity
NtRootA1_16910	COG2814	Major facilitator Superfamily
NtRootA1_16930	COG1271	oxidase subunit
NtRootA1_16940	COG1294	oxidase, subunit
NtRootA1_16950	COG4988	ABC transporter
NtRootA1_16990	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NtRootA1_17000	COG0045	succinate-CoA ligase (ADP-forming) activity
NtRootA1_17000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NtRootA1_17000	COG1042	CoA-binding domain protein
NtRootA1_17030	COG1435	thymidine kinase activity
NtRootA1_17070	COG0756	dUTP diphosphatase activity
NtRootA1_17120	COG0569	domain protein
NtRootA1_17130	COG0531	amino acid
NtRootA1_17140	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NtRootA1_17150	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NtRootA1_17160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NtRootA1_17200	COG0667	Aldo Keto reductase
NtRootA1_17210	COG1250	3-hydroxyacyl-CoA dehydrogenase
NtRootA1_17210	COG1024	Enoyl-CoA hydratase
NtRootA1_17220	COG0183	Belongs to the thiolase family
NtRootA1_17280	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NtRootA1_17310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NtRootA1_17350	COG3135	benzoate transporter
NtRootA1_17370	COG0531	amino acid
NtRootA1_17440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NtRootA1_17440	COG3321	synthase
NtRootA1_17440	COG0604	alcohol dehydrogenase
NtRootA1_17440	COG4221	oxidoreductase activity
NtRootA1_17450	COG0789	Transcriptional regulator
NtRootA1_17460	COG3119	arylsulfatase activity
NtRootA1_17470	COG2271	Major facilitator Superfamily
NtRootA1_17550	COG0242	peptide deformylase activity
NtRootA1_17560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NtRootA1_17580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NtRootA1_17630	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NtRootA1_17630	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NtRootA1_17640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NtRootA1_17640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NtRootA1_17650	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NtRootA1_17660	COG0140	phosphoribosyl-ATP diphosphatase activity
NtRootA1_17670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NtRootA1_17680	COG0107	imidazoleglycerol-phosphate synthase activity
NtRootA1_17710	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NtRootA1_17750	COG0134	indole-3-glycerol-phosphate synthase activity
NtRootA1_17760	COG0133	tryptophan synthase activity
NtRootA1_17770	COG0159	tryptophan synthase activity
NtRootA1_17780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NtRootA1_17790	COG0067	glutamate synthase
NtRootA1_17790	COG0070	glutamate synthase
NtRootA1_17790	COG0069	glutamate synthase activity
NtRootA1_17830	COG0582	viral genome integration into host DNA
NtRootA1_18110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NtRootA1_18160	COG2211	Major facilitator Superfamily
NtRootA1_18180	COG1609	Transcriptional regulator
NtRootA1_18190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NtRootA1_18260	COG1309	transcriptional regulator
NtRootA1_18270	COG2814	Major facilitator Superfamily
NtRootA1_18280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NtRootA1_18300	COG1609	Transcriptional regulator
NtRootA1_18330	COG4221	oxidoreductase activity
NtRootA1_18350	COG0596	Alpha beta hydrolase
NtRootA1_18370	COG1024	Enoyl-CoA hydratase
NtRootA1_18380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NtRootA1_18410	COG0477	Major facilitator Superfamily
NtRootA1_18430	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootA1_18450	COG0183	Belongs to the thiolase family
NtRootA1_18490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NtRootA1_18510	COG1609	Transcriptional regulator
NtRootA1_18520	COG0747	negative chemotaxis
NtRootA1_18530	COG0601	transmembrane transport
NtRootA1_18550	COG4172	Belongs to the ABC transporter superfamily
NtRootA1_18590	COG1609	Transcriptional regulator
NtRootA1_18640	COG1349	DNA-binding transcription factor activity
NtRootA1_18650	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NtRootA1_18670	COG0601	transmembrane transport
NtRootA1_18680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootA1_18690	COG0444	Belongs to the ABC transporter superfamily
NtRootA1_18700	COG4608	Belongs to the ABC transporter superfamily
NtRootA1_18710	COG0667	Aldo Keto reductase
NtRootA1_18740	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_18770	COG3415	Transposase
NtRootA1_18770	COG2801	Transposase and inactivated derivatives
NtRootA1_18790	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_18850	COG0028	Belongs to the TPP enzyme family
NtRootA1_18860	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NtRootA1_18890	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootA1_18920	COG0444	Belongs to the ABC transporter superfamily
NtRootA1_19010	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_19020	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_19040	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NtRootA1_19150	COG1175	transmembrane transport
NtRootA1_19160	COG0395	ABC-type sugar transport system, permease component
NtRootA1_19170	COG1472	Belongs to the glycosyl hydrolase 3 family
NtRootA1_19180	COG2723	6-phospho-beta-galactosidase activity
NtRootA1_19210	COG0673	inositol 2-dehydrogenase activity
NtRootA1_19220	COG0673	inositol 2-dehydrogenase activity
NtRootA1_19240	COG1940	carbohydrate kinase activity
NtRootA1_19270	COG2124	cytochrome p450
NtRootA1_19300	COG2409	Drug exporters of the RND superfamily
NtRootA1_19310	COG4585	Histidine kinase
NtRootA1_19320	COG2197	response regulator
NtRootA1_19330	COG1472	Belongs to the glycosyl hydrolase 3 family
NtRootA1_19340	COG2723	6-phospho-beta-galactosidase activity
NtRootA1_19350	COG3250	beta-galactosidase activity
NtRootA1_19360	COG1472	Belongs to the glycosyl hydrolase 3 family
NtRootA1_19380	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_19400	COG3250	beta-galactosidase activity
NtRootA1_19410	COG2211	Major facilitator Superfamily
NtRootA1_19420	COG3507	Belongs to the glycosyl hydrolase 43 family
NtRootA1_19490	COG0765	amino acid transport
NtRootA1_19500	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_19510	COG1126	abc transporter atp-binding protein
NtRootA1_19520	COG1126	abc transporter atp-binding protein
NtRootA1_19530	COG1053	succinate dehydrogenase
NtRootA1_19540	COG0477	Major facilitator Superfamily
NtRootA1_19550	COG1234	tRNA 3'-trailer cleavage
NtRootA1_19590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NtRootA1_19610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NtRootA1_19630	COG1609	Transcriptional regulator
NtRootA1_19650	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NtRootA1_19660	COG4209	transmembrane transport
NtRootA1_19670	COG0395	ABC-type sugar transport system, permease component
NtRootA1_19700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NtRootA1_19740	COG1609	Transcriptional regulator
NtRootA1_19750	COG1609	Transcriptional regulator
NtRootA1_19770	COG0395	ABC-type sugar transport system, permease component
NtRootA1_19780	COG1175	transmembrane transport
NtRootA1_19810	COG1609	Transcriptional regulator
NtRootA1_19850	COG3328	transposase activity
NtRootA1_19980	COG1063	alcohol dehydrogenase
NtRootA1_20010	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA1_20020	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootA1_20030	COG1960	acyl-CoA dehydrogenase activity
NtRootA1_20040	COG1960	acyl-CoA dehydrogenase activity
NtRootA1_20070	COG1250	3-hydroxyacyl-CoA dehydrogenase
NtRootA1_20070	COG1024	Enoyl-CoA hydratase
NtRootA1_20080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NtRootA1_20140	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NtRootA1_20190	COG1309	transcriptional regulator
NtRootA1_20220	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_20240	COG1053	succinate dehydrogenase
NtRootA1_20260	COG0596	Alpha beta hydrolase
NtRootA1_20270	COG0633	Ferredoxin
NtRootA1_20320	COG1250	3-hydroxyacyl-CoA dehydrogenase
NtRootA1_20330	COG1024	Enoyl-CoA hydratase
NtRootA1_20340	COG0183	Belongs to the thiolase family
NtRootA1_20350	COG0702	epimerase
NtRootA1_20390	COG1129	ABC transporter
NtRootA1_20440	COG3384	dioxygenase
NtRootA1_20500	COG3119	arylsulfatase activity
NtRootA1_20530	COG2149	membrane
NtRootA1_20540	COG3265	gluconokinase activity
NtRootA1_20550	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootA1_20560	COG0246	Mannitol dehydrogenase
NtRootA1_20570	COG1904	glucuronate isomerase
NtRootA1_20580	COG1609	Transcriptional regulator
NtRootA1_20590	COG3119	arylsulfatase activity
NtRootA1_20610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootA1_20620	COG0601	transmembrane transport
NtRootA1_20630	COG0747	negative chemotaxis
NtRootA1_20640	COG1609	Transcriptional regulator
NtRootA1_20650	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA1_20680	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA1_20700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NtRootA1_20730	COG3119	arylsulfatase activity
NtRootA1_20750	COG3250	beta-galactosidase activity
NtRootA1_20780	COG0601	transmembrane transport
NtRootA1_20810	COG1414	Transcriptional regulator
NtRootA1_20830	COG2124	cytochrome p450
NtRootA1_20850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NtRootA1_20860	COG0251	oxidation-reduction process
NtRootA1_20870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NtRootA1_20880	COG0477	Major facilitator Superfamily
NtRootA1_20970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NtRootA1_20980	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA1_20990	COG0145	ligase activity
NtRootA1_21020	COG3962	Belongs to the TPP enzyme family
NtRootA1_21030	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_21040	COG0673	inositol 2-dehydrogenase activity
NtRootA1_21050	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_21060	COG0129	dihydroxy-acid dehydratase activity
NtRootA1_21070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NtRootA1_21090	COG0673	inositol 2-dehydrogenase activity
NtRootA1_21100	COG1129	ABC transporter
NtRootA1_21110	COG1172	Belongs to the binding-protein-dependent transport system permease family
NtRootA1_21130	COG0247	lactate metabolic process
NtRootA1_21130	COG0277	FAD linked oxidase domain protein
NtRootA1_21240	COG1609	Transcriptional regulator
NtRootA1_21280	COG2508	Transcriptional regulator
NtRootA1_21290	COG0477	Major facilitator Superfamily
NtRootA1_21300	COG0028	Belongs to the TPP enzyme family
NtRootA1_21310	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_21320	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NtRootA1_21330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NtRootA1_21350	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_21370	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_21380	COG0596	Alpha beta hydrolase
NtRootA1_21440	COG1609	Transcriptional regulator
NtRootA1_21450	COG1082	Xylose isomerase domain protein TIM barrel
NtRootA1_21460	COG2814	Major facilitator Superfamily
NtRootA1_21510	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootA1_21520	COG1960	acyl-CoA dehydrogenase activity
NtRootA1_21530	COG0183	Belongs to the thiolase family
NtRootA1_21540	COG1024	Enoyl-CoA hydratase
NtRootA1_21540	COG1250	3-hydroxyacyl-CoA dehydrogenase
NtRootA1_21570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NtRootA1_21580	COG2267	carboxylic ester hydrolase activity
NtRootA1_21600	COG1073	alpha beta
NtRootA1_21630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NtRootA1_21670	COG0604	alcohol dehydrogenase
NtRootA1_21680	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_21720	COG0800	Aldolase
NtRootA1_21740	COG1609	Transcriptional regulator
NtRootA1_21840	COG0395	ABC-type sugar transport system, permease component
NtRootA1_21850	COG1175	transmembrane transport
NtRootA1_21870	COG1609	Transcriptional regulator
NtRootA1_21890	COG0747	negative chemotaxis
NtRootA1_21930	COG3250	beta-galactosidase activity
NtRootA1_21940	COG3507	Belongs to the glycosyl hydrolase 43 family
NtRootA1_22000	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_22030	COG1472	Belongs to the glycosyl hydrolase 3 family
NtRootA1_22060	COG2084	Dehydrogenase
NtRootA1_22070	COG1082	Xylose isomerase domain protein TIM barrel
NtRootA1_22080	COG0149	triose-phosphate isomerase activity
NtRootA1_22090	COG0698	ribose 5-phosphate isomerase
NtRootA1_22100	COG2376	Dihydroxyacetone kinase
NtRootA1_22120	COG2186	Transcriptional regulator
NtRootA1_22150	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NtRootA1_22220	COG0154	amidase activity
NtRootA1_22260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NtRootA1_22300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NtRootA1_22330	COG0659	secondary active sulfate transmembrane transporter activity
NtRootA1_22390	COG0842	Transport permease protein
NtRootA1_22400	COG1131	(ABC) transporter
NtRootA1_22470	COG1131	(ABC) transporter
NtRootA1_22510	COG0574	Belongs to the PEP-utilizing enzyme family
NtRootA1_22510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NtRootA1_22560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NtRootA1_22630	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NtRootA1_22690	COG1063	alcohol dehydrogenase
NtRootA1_22700	COG2217	Heavy metal translocating P-type atpase
NtRootA1_22720	COG0280	phosphate acetyltransferase
NtRootA1_22720	COG0857	belongs to the CobB CobQ family
NtRootA1_22740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NtRootA1_22760	COG0589	response to stress
NtRootA1_22770	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NtRootA1_22780	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NtRootA1_22790	COG2132	Multicopper oxidase
NtRootA1_22840	COG2207	Transcriptional regulator
NtRootA1_22850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NtRootA1_22930	COG1793	dna ligase
NtRootA1_22950	COG0477	Major facilitator Superfamily
NtRootA1_22960	COG2175	clavaminate synthase activity
NtRootA1_22980	COG2080	2 iron, 2 sulfur cluster binding
NtRootA1_22990	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NtRootA1_23010	COG2271	Major facilitator Superfamily
NtRootA1_23020	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_23090	COG0028	Belongs to the TPP enzyme family
NtRootA1_23130	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
NtRootA1_23140	COG1846	Transcriptional regulator
NtRootA1_23200	COG2072	flavoprotein involved in K transport
NtRootA1_23210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NtRootA1_23250	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_23270	COG0531	amino acid
NtRootA1_23290	COG0511	ligase activity, forming carbon-carbon bonds
NtRootA1_23290	COG5016	pyruvate
NtRootA1_23300	COG0511	ligase activity, forming carbon-carbon bonds
NtRootA1_23310	COG0439	Biotin carboxylase
NtRootA1_23340	COG0183	Belongs to the thiolase family
NtRootA1_23350	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootA1_23430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NtRootA1_23450	COG3119	arylsulfatase activity
NtRootA1_23460	COG0747	negative chemotaxis
NtRootA1_23500	COG3119	arylsulfatase activity
NtRootA1_23510	COG3119	arylsulfatase activity
NtRootA1_23530	COG3119	arylsulfatase activity
NtRootA1_23550	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA1_23580	COG2814	Major facilitator Superfamily
NtRootA1_23590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NtRootA1_23610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NtRootA1_23620	COG0464	growth
NtRootA1_23710	COG3619	membrane
NtRootA1_23720	COG2188	Transcriptional regulator
NtRootA1_23730	COG0405	Gamma-glutamyltransferase
NtRootA1_23750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NtRootA1_23770	COG0022	dehydrogenase e1 component
NtRootA1_23780	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA1_23800	COG1960	acyl-CoA dehydrogenase activity
NtRootA1_23830	COG2271	Major facilitator Superfamily
NtRootA1_23890	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA1_23920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootA1_23980	COG1609	Transcriptional regulator
NtRootA1_23990	COG2814	Major facilitator Superfamily
NtRootA1_24020	COG1250	3-hydroxyacyl-CoA dehydrogenase
NtRootA1_24020	COG1024	Enoyl-CoA hydratase
NtRootA1_24030	COG0183	Belongs to the thiolase family
NtRootA1_24080	COG1175	transmembrane transport
NtRootA1_24090	COG0395	ABC-type sugar transport system, permease component
NtRootA1_24120	COG1609	Transcriptional regulator
NtRootA1_24150	COG0395	ABC-type sugar transport system, permease component
NtRootA1_24190	COG4176	ABC-type proline glycine betaine transport system permease component
NtRootA1_24200	COG4175	Glycine betaine
NtRootA1_24200	COG0517	IMP dehydrogenase activity
NtRootA1_24210	COG0583	DNA-binding transcription factor activity
NtRootA1_24300	COG2197	response regulator
NtRootA1_24360	COG0028	Belongs to the TPP enzyme family
NtRootA1_24370	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NtRootA1_24390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NtRootA1_24410	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_24440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA1_24450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NtRootA1_24660	COG2272	Belongs to the type-B carboxylesterase lipase family
NtRootA1_24730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NtRootA1_24740	COG3424	synthase
NtRootA1_24750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NtRootA1_24780	COG0242	peptide deformylase activity
NtRootA1_24800	COG2226	methyltransferase
NtRootA1_24840	COG1216	Glycosyl transferase, family 2
NtRootA1_24850	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NtRootA1_24860	COG4581	dead DEAH box helicase
NtRootA1_24870	COG0805	protein transport
NtRootA1_24880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NtRootA1_24920	COG0545	Peptidyl-prolyl cis-trans isomerase
NtRootA1_24930	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NtRootA1_24940	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NtRootA1_24950	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NtRootA1_24970	COG4122	O-methyltransferase activity
NtRootA1_24980	COG1222	aaa ATPase
NtRootA1_25000	COG1994	Peptidase M50
NtRootA1_25000	COG0517	IMP dehydrogenase activity
NtRootA1_25010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NtRootA1_25030	COG0215	cysteine-tRNA ligase activity
NtRootA1_25040	COG1968	undecaprenyl-diphosphatase activity
NtRootA1_25050	COG0656	L-ascorbic acid biosynthetic process
NtRootA1_25060	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NtRootA1_25070	COG1088	dTDP-glucose 4,6-dehydratase activity
NtRootA1_25190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NtRootA1_25220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NtRootA1_25320	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_25330	COG0183	Belongs to the thiolase family
NtRootA1_25360	COG0297	glycogen (starch) synthase activity
NtRootA1_25380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NtRootA1_25440	COG2855	membrane
NtRootA1_25470	COG0254	rRNA binding
NtRootA1_25510	COG0477	Major facilitator Superfamily
NtRootA1_25520	COG1473	amidohydrolase
NtRootA1_25540	COG1522	sequence-specific DNA binding
NtRootA1_25550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NtRootA1_25570	COG1113	amino acid transport
NtRootA1_25590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NtRootA1_25610	COG0477	Major facilitator Superfamily
NtRootA1_25620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NtRootA1_25650	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_25700	COG1119	ATPase activity
NtRootA1_25710	COG3830	Belongs to the UPF0237 family
NtRootA1_25710	COG0560	Phosphoserine phosphatase
NtRootA1_25750	COG1129	ABC transporter
NtRootA1_25760	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_25770	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_25830	COG0488	(ABC) transporter
NtRootA1_25840	COG1268	BioY protein
NtRootA1_25850	COG1122	ATPase activity
NtRootA1_25860	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NtRootA1_25880	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootA1_25900	COG2151	metal-sulfur cluster biosynthetic enzyme
NtRootA1_25910	COG0396	ATPase activity
NtRootA1_25960	COG1131	(ABC) transporter
NtRootA1_25980	COG1612	heme a metabolic process
NtRootA1_25990	COG0109	protoheme IX farnesyltransferase activity
NtRootA1_26010	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NtRootA1_26020	COG0166	Belongs to the GPI family
NtRootA1_26050	COG0363	glucosamine-6-phosphate deaminase activity
NtRootA1_26070	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NtRootA1_26080	COG0149	triose-phosphate isomerase activity
NtRootA1_26090	COG0126	phosphoglycerate kinase activity
NtRootA1_26100	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NtRootA1_26110	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NtRootA1_26120	COG1481	regulation of sporulation
NtRootA1_26140	COG1660	Displays ATPase and GTPase activities
NtRootA1_26150	COG0322	excinuclease ABC activity
NtRootA1_26170	COG0546	phosphoglycolate phosphatase activity
NtRootA1_26200	COG4106	trans-aconitate 2-methyltransferase activity
NtRootA1_26220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NtRootA1_26270	COG0556	nucleotide-excision repair
NtRootA1_26280	COG0237	dephospho-CoA kinase activity
NtRootA1_26280	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NtRootA1_26290	COG1739	Uncharacterized protein family UPF0029
NtRootA1_26310	COG0539	negative regulation of cytoplasmic translation
NtRootA1_26330	COG4552	Acetyltransferase involved in intracellular survival and related
NtRootA1_26350	COG2050	protein possibly involved in aromatic compounds catabolism
NtRootA1_26360	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NtRootA1_26420	COG3483	tryptophan 2,3-dioxygenase activity
NtRootA1_26450	COG2188	Transcriptional regulator
NtRootA1_26460	COG2814	Major facilitator Superfamily
NtRootA1_26470	COG2971	BadF BadG BcrA BcrD
NtRootA1_26480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NtRootA1_26520	COG0009	L-threonylcarbamoyladenylate synthase
NtRootA1_26610	COG1643	Atp-dependent helicase
NtRootA1_26620	COG1064	alcohol dehydrogenase
NtRootA1_26660	COG3795	YCII-related domain
NtRootA1_26680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NtRootA1_26730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NtRootA1_26820	COG0460	homoserine dehydrogenase
NtRootA1_26830	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_26860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NtRootA1_26870	COG0028	Belongs to the TPP enzyme family
NtRootA1_26880	COG1793	dna ligase
NtRootA1_26880	COG3285	dna ligase
NtRootA1_26920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NtRootA1_26930	COG1845	cytochrome c oxidase, subunit III
NtRootA1_26940	COG2010	Cytochrome c
NtRootA1_26950	COG0723	plastoquinol--plastocyanin reductase activity
NtRootA1_26960	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NtRootA1_26970	COG2188	Transcriptional regulator
NtRootA1_26980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NtRootA1_27000	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NtRootA1_27010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NtRootA1_27060	COG0167	dihydroorotate dehydrogenase activity
NtRootA1_27090	COG0596	Alpha beta hydrolase
NtRootA1_27090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NtRootA1_27090	COG2226	methyltransferase
NtRootA1_27100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NtRootA1_27110	COG1381	Involved in DNA repair and RecF pathway recombination
NtRootA1_27120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NtRootA1_27130	COG3590	peptidase
NtRootA1_27140	COG1316	TRANSCRIPTIONal
NtRootA1_27150	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NtRootA1_27170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NtRootA1_27200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NtRootA1_27210	COG0484	heat shock protein binding
NtRootA1_27220	COG1420	regulation of RNA biosynthetic process
NtRootA1_27260	COG0481	GTPase activity
NtRootA1_27280	COG0268	Binds directly to 16S ribosomal RNA
NtRootA1_27330	COG1307	EDD domain protein, DegV family
NtRootA1_27340	COG0495	leucyl-tRNA aminoacylation
NtRootA1_27350	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NtRootA1_27360	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NtRootA1_27370	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NtRootA1_27380	COG2390	Transcriptional regulator
NtRootA1_27390	COG0656	L-ascorbic acid biosynthetic process
NtRootA1_27430	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NtRootA1_27450	COG1758	RNA polymerase activity
NtRootA1_27460	COG0194	GDP metabolic process
NtRootA1_27480	COG0284	orotidine-5'-phosphate decarboxylase activity
NtRootA1_27490	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NtRootA1_27500	COG0505	Belongs to the CarA family
NtRootA1_27520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NtRootA1_27530	COG0540	Belongs to the ATCase OTCase family
NtRootA1_27540	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NtRootA1_27560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NtRootA1_27570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NtRootA1_27590	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NtRootA1_27620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NtRootA1_27630	COG0710	3-dehydroquinate dehydratase activity
NtRootA1_27630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NtRootA1_27660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NtRootA1_27690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NtRootA1_27720	COG0456	acetyltransferase
NtRootA1_27730	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NtRootA1_27740	COG0124	histidyl-tRNA synthetase
NtRootA1_27760	COG1196	nuclear chromosome segregation
NtRootA1_27780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NtRootA1_27790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NtRootA1_27800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NtRootA1_27820	COG2255	four-way junction helicase activity
NtRootA1_27830	COG0632	four-way junction helicase activity
NtRootA1_27840	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NtRootA1_27850	COG0217	transcriptional regulatory protein
NtRootA1_27860	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NtRootA1_27910	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NtRootA1_27920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NtRootA1_27940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NtRootA1_27950	COG0587	DNA-directed DNA polymerase activity
NtRootA1_28000	COG2135	peptidase activity
NtRootA1_28070	COG0723	plastoquinol--plastocyanin reductase activity
NtRootA1_28100	COG4804	nuclease activity
NtRootA1_28140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NtRootA1_28150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NtRootA1_28160	COG1780	Probably involved in ribonucleotide reductase function
NtRootA1_28180	COG0583	DNA-binding transcription factor activity
NtRootA1_28260	COG0714	Associated with various cellular activities
NtRootA1_28280	COG3833	ABC-type maltose transport systems, permease component
NtRootA1_28290	COG1175	transmembrane transport
NtRootA1_28320	COG2813	Specifically methylates the guanine in position
NtRootA1_28350	COG0799	negative regulation of ribosome biogenesis
NtRootA1_28370	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NtRootA1_28390	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NtRootA1_28400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NtRootA1_28410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NtRootA1_28420	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NtRootA1_28430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NtRootA1_28440	COG0351	phosphomethylpyrimidine kinase
NtRootA1_28440	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NtRootA1_28440	COG0352	thiamine-phosphate diphosphorylase activity
NtRootA1_28450	COG1530	ribonuclease E activity
NtRootA1_28490	COG0105	UTP biosynthetic process
NtRootA1_28510	COG0285	dihydrofolate synthase activity
NtRootA1_28520	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NtRootA1_28550	COG0525	valine-tRNA ligase activity
NtRootA1_28560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NtRootA1_28570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NtRootA1_28580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NtRootA1_28590	COG0740	serine-type endopeptidase activity
NtRootA1_28600	COG0740	serine-type endopeptidase activity
NtRootA1_28610	COG0544	peptidyl-prolyl cis-trans isomerase activity
NtRootA1_28690	COG0668	transmembrane transport
NtRootA1_28720	COG1946	Acyl-CoA thioesterase
NtRootA1_28760	COG0629	single-stranded DNA binding
NtRootA1_28820	COG0242	peptide deformylase activity
NtRootA1_28870	COG3022	response to hydroperoxide
NtRootA1_28890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NtRootA1_28900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NtRootA1_28920	COG1045	serine acetyltransferase
NtRootA1_28930	COG0300	oxidoreductase activity
NtRootA1_28940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NtRootA1_28960	COG1063	alcohol dehydrogenase
NtRootA1_28970	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_28990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootA1_29000	COG0477	Major facilitator Superfamily
NtRootA1_29060	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NtRootA1_29090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NtRootA1_29100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NtRootA1_29500	COG0542	response to heat
NtRootA1_29530	COG0085	RNA polymerase activity
NtRootA1_29600	COG1793	dna ligase
NtRootA1_29730	COG1074	ATP-dependent DNA helicase activity
NtRootA1_29750	COG0542	response to heat
NtRootA1_29880	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_29900	COG0500	methyltransferase
NtRootA1_30070	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
NtRootA1_30270	COG0750	zinc metalloprotease
NtRootA1_30730	COG0210	DNA helicase
NtRootA1_30770	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NtRootA1_30930	COG1595	DNA-templated transcription, initiation
NtRootA1_31020	COG1607	acyl-coa hydrolase
NtRootA1_31030	COG0583	DNA-binding transcription factor activity
NtRootA1_31050	COG1960	acyl-CoA dehydrogenase activity
NtRootA1_31070	COG1024	Enoyl-CoA hydratase
NtRootA1_31080	COG1250	3-hydroxyacyl-CoA dehydrogenase
NtRootA1_31120	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_31140	COG0657	acetylesterase activity
NtRootA1_31190	COG0477	Major facilitator Superfamily
NtRootA1_31240	COG2197	response regulator
NtRootA1_31250	COG4585	Histidine kinase
NtRootA1_31300	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NtRootA1_31300	COG0517	IMP dehydrogenase activity
NtRootA1_31310	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NtRootA1_31330	COG0792	nuclease activity
NtRootA1_31350	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NtRootA1_31370	COG0681	Belongs to the peptidase S26 family
NtRootA1_31380	COG0335	large ribosomal subunit rRNA binding
NtRootA1_31390	COG0336	Belongs to the RNA methyltransferase TrmD family
NtRootA1_31400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NtRootA1_31410	COG1837	Belongs to the UPF0109 family
NtRootA1_31420	COG0228	four-way junction DNA binding
NtRootA1_31440	COG2514	catechol 2,3-dioxygenase activity
NtRootA1_31490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NtRootA1_31520	COG2814	Major facilitator Superfamily
NtRootA1_31600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NtRootA1_31610	COG0571	ribonuclease III activity
NtRootA1_31620	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NtRootA1_31640	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NtRootA1_31670	COG0742	ribosomal rna small subunit methyltransferase
NtRootA1_31720	COG1181	Belongs to the D-alanine--D-alanine ligase family
NtRootA1_31730	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NtRootA1_31750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NtRootA1_31760	COG0066	3-isopropylmalate dehydratase activity
NtRootA1_31770	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NtRootA1_31780	COG1414	Transcriptional regulator
NtRootA1_31830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NtRootA1_31840	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA1_31860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NtRootA1_31870	COG0473	3-isopropylmalate dehydrogenase activity
NtRootA1_31880	COG4585	Histidine kinase
NtRootA1_31890	COG2197	response regulator
NtRootA1_31900	COG1136	(ABC) transporter
NtRootA1_31900	COG0577	efflux transmembrane transporter activity
NtRootA1_31910	COG2177	Part of the ABC transporter FtsEX involved in
NtRootA1_31930	COG0577	efflux transmembrane transporter activity
NtRootA1_31930	COG1136	(ABC) transporter
NtRootA1_31950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootA1_31960	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NtRootA1_31970	COG0440	acetolactate synthase activity
NtRootA1_31990	COG0129	dihydroxy-acid dehydratase activity
NtRootA1_32000	COG0088	Forms part of the polypeptide exit tunnel
NtRootA1_32010	COG2133	pyrroloquinoline quinone binding
NtRootA1_32050	COG0747	negative chemotaxis
NtRootA1_32060	COG0579	oxidoreductase
NtRootA1_32070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NtRootA1_32080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA1_32100	COG1305	Transglutaminase-like
NtRootA1_32170	COG1104	cysteine desulfurase activity
NtRootA1_32190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NtRootA1_32210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NtRootA1_32230	COG1522	sequence-specific DNA binding
NtRootA1_32240	COG1113	amino acid transport
NtRootA1_32260	COG0022	dehydrogenase e1 component
NtRootA1_32270	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA1_32310	COG0477	Major facilitator Superfamily
NtRootA1_32370	COG1116	anion transmembrane transporter activity
NtRootA1_32380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NtRootA1_32450	COG0419	ATPase involved in DNA repair
NtRootA1_32460	COG0420	3'-5' exonuclease activity
NtRootA1_32490	COG2149	membrane
NtRootA1_32530	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NtRootA1_32540	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NtRootA1_32550	COG1234	tRNA 3'-trailer cleavage
NtRootA1_32560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NtRootA1_32580	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NtRootA1_32600	COG1335	isochorismatase
NtRootA1_32630	COG0363	glucosamine-6-phosphate deaminase activity
NtRootA1_32660	COG1902	pentaerythritol trinitrate reductase activity
NtRootA1_32690	COG0628	permease
NtRootA1_32720	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
NtRootA1_32750	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NtRootA1_32760	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NtRootA1_32780	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NtRootA1_32790	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NtRootA1_32800	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NtRootA1_32810	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NtRootA1_32820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NtRootA1_32830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NtRootA1_32840	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NtRootA1_32850	COG0356	it plays a direct role in the translocation of protons across the membrane
NtRootA1_32880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NtRootA1_32920	COG2890	protein-(glutamine-N5) methyltransferase activity
NtRootA1_32930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NtRootA1_32950	COG0083	homoserine kinase activity
NtRootA1_32960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NtRootA1_32970	COG0460	homoserine dehydrogenase
NtRootA1_32980	COG0019	diaminopimelate decarboxylase activity
NtRootA1_32990	COG0018	arginyl-trna synthetase
NtRootA1_33020	COG1017	nitric oxide dioxygenase activity
NtRootA1_33020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NtRootA1_33070	COG1643	Atp-dependent helicase
NtRootA1_33080	COG0537	adenosine 5'-monophosphoramidase activity
NtRootA1_33090	COG1064	alcohol dehydrogenase
NtRootA1_33170	COG1121	(ABC) transporter
NtRootA1_33200	COG1253	flavin adenine dinucleotide binding
NtRootA1_33210	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA1_33210	COG0567	Dehydrogenase, E1 component
NtRootA1_33260	COG1595	DNA-templated transcription, initiation
NtRootA1_33280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NtRootA1_33300	COG0483	inositol monophosphate 1-phosphatase activity
NtRootA1_33310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NtRootA1_33370	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NtRootA1_33390	COG2177	Part of the ABC transporter FtsEX involved in
NtRootA1_33400	COG2884	Cell division ATP-binding protein ftsE
NtRootA1_33410	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NtRootA1_33590	COG1216	Glycosyl transferase, family 2
NtRootA1_33620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NtRootA1_33680	COG2902	Dehydrogenase
NtRootA1_33750	COG0653	protein targeting
NtRootA1_33760	COG3214	Protein conserved in bacteria
NtRootA1_33770	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NtRootA1_33790	COG5401	PFAM Sporulation and spore germination
NtRootA1_33800	COG5002	protein histidine kinase activity
NtRootA1_33810	COG0745	RESPONSE REGULATOR receiver
NtRootA1_33850	COG0714	Associated with various cellular activities
NtRootA1_33920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootA1_33930	COG0601	transmembrane transport
NtRootA1_33970	COG0482	sulfurtransferase activity
NtRootA1_34040	COG0484	heat shock protein binding
NtRootA1_34050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NtRootA1_34060	COG1595	DNA-templated transcription, initiation
NtRootA1_34090	COG3265	gluconokinase activity
NtRootA1_34110	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NtRootA1_34120	COG2086	electron transfer activity
NtRootA1_34130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NtRootA1_34150	COG1842	Phage shock protein A
NtRootA1_34160	COG2188	Transcriptional regulator
NtRootA1_34170	COG1615	UPF0182 protein
NtRootA1_34180	COG3480	Lon protease (S16) C-terminal proteolytic domain
NtRootA1_34220	COG2816	NAD+ diphosphatase activity
NtRootA1_34280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA1_34290	COG0765	amino acid transport
NtRootA1_34300	COG1126	abc transporter atp-binding protein
NtRootA1_34310	COG1472	Belongs to the glycosyl hydrolase 3 family
NtRootA1_34330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NtRootA1_34350	COG0113	porphobilinogen synthase activity
NtRootA1_34370	COG0181	hydroxymethylbilane synthase activity
NtRootA1_34380	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NtRootA1_34390	COG3253	May function as heme-dependent peroxidase
NtRootA1_34400	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NtRootA1_34410	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NtRootA1_34420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NtRootA1_34450	COG1309	transcriptional regulator
NtRootA1_34510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NtRootA1_34510	COG2022	thiamine diphosphate biosynthetic process
NtRootA1_34520	COG0352	thiamine-phosphate diphosphorylase activity
NtRootA1_34550	COG0513	Belongs to the DEAD box helicase family
NtRootA1_34590	COG0006	proline dipeptidase activity
NtRootA1_34610	COG2239	Acts as a magnesium transporter
NtRootA1_34640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NtRootA1_34660	COG1595	DNA-templated transcription, initiation
NtRootA1_34720	COG1126	abc transporter atp-binding protein
NtRootA1_34730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA1_34740	COG0765	amino acid transport
NtRootA1_34750	COG0765	amino acid transport
NtRootA1_34760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NtRootA1_34770	COG2171	N-acyltransferase activity
NtRootA1_34800	COG3226	Transcriptional regulator
NtRootA1_34810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NtRootA1_34870	COG1217	gtp-binding protein TYPA
NtRootA1_34900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootA1_34910	COG0601	transmembrane transport
NtRootA1_34940	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NtRootA1_34990	COG0012	GTP binding
NtRootA1_35000	COG1322	Protein conserved in bacteria
NtRootA1_35010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NtRootA1_35030	COG1570	exodeoxyribonuclease VII activity
NtRootA1_35040	COG1722	exodeoxyribonuclease VII activity
NtRootA1_35050	COG2326	polyphosphate kinase activity
NtRootA1_35090	COG1174	glycine betaine transport
NtRootA1_35110	COG1162	GTPase activity
NtRootA1_35120	COG1162	GTPase activity
NtRootA1_35160	COG2971	BadF BadG BcrA BcrD
NtRootA1_35180	COG0583	DNA-binding transcription factor activity
NtRootA1_35190	COG2814	Major facilitator Superfamily
NtRootA1_35200	COG3548	integral membrane protein
NtRootA1_35250	COG0598	Magnesium transport protein CorA
NtRootA1_35280	COG1528	Iron-storage protein
NtRootA1_35290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NtRootA1_35300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NtRootA1_35320	COG2824	Alkylphosphonate utilization operon protein PhnA
NtRootA1_35330	COG1278	Cold shock
NtRootA1_35400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NtRootA1_35410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NtRootA1_35450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NtRootA1_35450	COG0519	Catalyzes the synthesis of GMP from XMP
NtRootA1_35490	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NtRootA1_35500	COG0516	GMP reductase activity
NtRootA1_35510	COG1132	(ABC) transporter
NtRootA1_35550	COG2072	flavoprotein involved in K transport
NtRootA1_35580	COG2197	response regulator
NtRootA1_35590	COG0459	protein refolding
NtRootA1_35600	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NtRootA1_35630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NtRootA1_35640	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NtRootA1_35670	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NtRootA1_35680	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NtRootA1_35690	COG0456	acetyltransferase
NtRootA1_35710	COG0802	atpase or kinase
NtRootA1_35720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NtRootA1_35760	COG0438	transferase activity, transferring glycosyl groups
NtRootA1_35770	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NtRootA1_35790	COG0667	Aldo Keto reductase
NtRootA1_35840	COG0736	holo-[acyl-carrier-protein] synthase activity
NtRootA1_35860	COG1072	(Pantothenic acid kinase))
NtRootA1_35880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NtRootA1_35890	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NtRootA1_35900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NtRootA1_35960	COG0455	bacterial-type flagellum organization
NtRootA1_36000	COG0101	tRNA pseudouridine synthase activity
NtRootA1_36020	COG0203	ribosomal protein L17
NtRootA1_36030	COG0202	RNA polymerase activity
NtRootA1_36040	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NtRootA1_36050	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NtRootA1_36060	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NtRootA1_36070	COG3191	aminopeptidase activity
NtRootA1_36100	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootA1_36110	COG2124	cytochrome p450
NtRootA1_36120	COG1216	Glycosyl transferase, family 2
NtRootA1_36130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NtRootA1_36140	COG0563	adenylate kinase activity
NtRootA1_36160	COG0200	Binds to the 23S rRNA
NtRootA1_36170	COG1841	ribosomal large subunit assembly
NtRootA1_36180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NtRootA1_36200	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NtRootA1_36210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NtRootA1_36220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NtRootA1_36230	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NtRootA1_36240	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NtRootA1_36250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NtRootA1_36260	COG0255	Belongs to the universal ribosomal protein uL29 family
NtRootA1_36270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NtRootA1_36280	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NtRootA1_36290	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NtRootA1_36300	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NtRootA1_36310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NtRootA1_36320	COG0089	rRNA binding
NtRootA1_36330	COG0088	Forms part of the polypeptide exit tunnel
NtRootA1_36340	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NtRootA1_36350	COG0051	transcription antitermination factor activity, RNA binding
NtRootA1_36390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NtRootA1_36400	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NtRootA1_36410	COG0049	tRNA binding
NtRootA1_36420	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NtRootA1_36440	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NtRootA1_36450	COG0085	RNA polymerase activity
NtRootA1_36470	COG0183	Belongs to the thiolase family
NtRootA1_36480	COG0442	prolyl-tRNA aminoacylation
NtRootA1_36500	COG0222	ribosome binding
NtRootA1_36510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NtRootA1_36540	COG0081	regulation of translation
NtRootA1_36550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NtRootA1_36570	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NtRootA1_36580	COG0436	Aminotransferase
NtRootA1_36590	COG2197	response regulator
NtRootA1_36680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NtRootA1_36700	COG3485	protocatechuate 3,4-dioxygenase
NtRootA1_36720	COG0745	RESPONSE REGULATOR receiver
NtRootA1_36730	COG0456	acetyltransferase
NtRootA1_36740	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NtRootA1_36760	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NtRootA1_36770	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NtRootA1_36790	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NtRootA1_36840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NtRootA1_36850	COG2030	dehydratase
NtRootA1_36860	COG2030	dehydratase
NtRootA1_36920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NtRootA1_36940	COG4989	oxidoreductase activity
NtRootA1_36950	COG0366	Alpha amylase catalytic
NtRootA1_36960	COG0395	ABC-type sugar transport system, permease component
NtRootA1_36970	COG1175	transmembrane transport
NtRootA1_36990	COG1940	carbohydrate kinase activity
NtRootA1_37080	COG0754	glutathionylspermidine amidase activity
NtRootA1_37100	COG5650	phosphatidylinositol metabolic process
NtRootA1_37140	COG5650	phosphatidylinositol metabolic process
NtRootA1_37200	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootA1_37220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NtRootA1_37240	COG1309	transcriptional regulator
NtRootA1_37250	COG1131	(ABC) transporter
NtRootA1_37290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NtRootA1_37310	COG1666	GTP binding
NtRootA1_37320	COG0672	)-iron permease
NtRootA1_37340	COG2837	iron assimilation
NtRootA1_37350	COG0501	Belongs to the peptidase M48B family
NtRootA1_37410	COG0531	amino acid
NtRootA1_37510	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_37520	COG3835	regulator
NtRootA1_37530	COG2807	transmembrane transport
NtRootA1_37540	COG2186	Transcriptional regulator
NtRootA1_37550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NtRootA1_37550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NtRootA1_37580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NtRootA1_37580	COG1648	precorrin-2 dehydrogenase activity
NtRootA1_37590	COG2066	Belongs to the glutaminase family
NtRootA1_37630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA1_37650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NtRootA1_37660	COG1116	anion transmembrane transporter activity
NtRootA1_37680	COG2040	homocysteine
NtRootA1_37720	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NtRootA1_37740	COG2860	membrane
NtRootA1_37780	COG0142	geranyltranstransferase activity
NtRootA1_37800	COG2226	methyltransferase
NtRootA1_37810	COG1169	isochorismate synthase
NtRootA1_37830	COG0765	amino acid transport
NtRootA1_37850	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NtRootA1_37860	COG1609	Transcriptional regulator
NtRootA1_37880	COG1175	transmembrane transport
NtRootA1_37890	COG0395	ABC-type sugar transport system, permease component
NtRootA1_37930	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootA1_37970	COG1609	Transcriptional regulator
NtRootA1_37980	COG1621	beta-fructofuranosidase activity
NtRootA1_37990	COG0395	ABC-type sugar transport system, permease component
NtRootA1_38000	COG1175	transmembrane transport
NtRootA1_38020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NtRootA1_38160	COG1404	Belongs to the peptidase S8 family
NtRootA1_38170	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA1_38180	COG0022	dehydrogenase e1 component
NtRootA1_38230	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NtRootA1_38290	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NtRootA1_38310	COG1134	teichoic acid transport
NtRootA1_38330	COG0438	transferase activity, transferring glycosyl groups
NtRootA1_38380	COG1316	TRANSCRIPTIONal
NtRootA1_38460	COG0489	protein tyrosine kinase activity
NtRootA1_38530	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NtRootA1_38540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NtRootA1_38560	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NtRootA1_38590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NtRootA1_38660	COG2828	Protein conserved in bacteria
NtRootA1_38670	COG0583	DNA-binding transcription factor activity
NtRootA1_38680	COG0671	phosphoesterase, PA-phosphatase related
NtRootA1_38710	COG5002	protein histidine kinase activity
NtRootA1_38720	COG0745	RESPONSE REGULATOR receiver
NtRootA1_38770	COG2894	cell division
NtRootA1_38830	COG5002	protein histidine kinase activity
NtRootA1_38850	COG0667	Aldo Keto reductase
NtRootA1_38860	COG1609	Transcriptional regulator
NtRootA1_38900	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NtRootA1_38910	COG1024	Enoyl-CoA hydratase
NtRootA1_38920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NtRootA1_38930	COG2151	metal-sulfur cluster biosynthetic enzyme
NtRootA1_38940	COG3396	Phenylacetate-CoA oxygenase
NtRootA1_38950	COG3460	Phenylacetate-CoA oxygenase
NtRootA1_38960	COG3396	Phenylacetate-CoA oxygenase
NtRootA1_38980	COG1388	LysM domain
NtRootA1_38980	COG3942	CHAP domain
NtRootA1_39010	COG2203	Gaf domain
NtRootA1_39010	COG3706	GGDEF domain
NtRootA1_39010	COG4251	negative regulation of phosphorylation
NtRootA1_39010	COG5001	Diguanylate cyclase
NtRootA1_39070	COG4106	trans-aconitate 2-methyltransferase activity
NtRootA1_39090	COG5002	protein histidine kinase activity
NtRootA1_39140	COG2050	protein possibly involved in aromatic compounds catabolism
NtRootA1_39180	COG0477	Major facilitator Superfamily
NtRootA1_39190	COG3119	arylsulfatase activity
NtRootA1_39210	COG1609	Transcriptional regulator
NtRootA1_39220	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_39220	COG2030	dehydratase
NtRootA1_39240	COG1609	Transcriptional regulator
NtRootA1_39270	COG0395	ABC-type sugar transport system, permease component
NtRootA1_39290	COG0673	inositol 2-dehydrogenase activity
NtRootA1_39300	COG0673	inositol 2-dehydrogenase activity
NtRootA1_39340	COG1250	3-hydroxyacyl-CoA dehydrogenase
NtRootA1_39350	COG1024	Enoyl-CoA hydratase
NtRootA1_39360	COG0183	Belongs to the thiolase family
NtRootA1_39400	COG2146	nitrite reductase [NAD(P)H] activity
NtRootA1_39410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NtRootA1_39430	COG0488	(ABC) transporter
NtRootA1_39440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NtRootA1_39450	COG1121	(ABC) transporter
NtRootA1_39460	COG0803	Belongs to the bacterial solute-binding protein 9 family
NtRootA1_39470	COG1266	CAAX protease self-immunity
NtRootA1_39480	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NtRootA1_39540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NtRootA1_39560	COG0785	Cytochrome C biogenesis protein
NtRootA1_39580	COG0406	alpha-ribazole phosphatase activity
NtRootA1_39640	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NtRootA1_39690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NtRootA1_39700	COG3458	cephalosporin-C deacetylase activity
NtRootA1_39720	COG2755	lipolytic protein G-D-S-L family
NtRootA1_39730	COG0395	ABC-type sugar transport system, permease component
NtRootA1_39740	COG4209	transmembrane transport
NtRootA1_39750	COG1653	transport
NtRootA1_39770	COG5578	integral membrane protein
NtRootA1_39790	COG2814	Major facilitator Superfamily
NtRootA1_39810	COG0395	ABC-type sugar transport system, permease component
NtRootA1_39820	COG1175	transmembrane transport
NtRootA1_39870	COG0395	ABC-type sugar transport system, permease component
NtRootA1_39880	COG1175	transmembrane transport
NtRootA1_39940	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootA1_39950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NtRootA1_39970	COG0673	inositol 2-dehydrogenase activity
NtRootA1_39980	COG1609	Transcriptional regulator
NtRootA1_39990	COG2186	Transcriptional regulator
NtRootA1_40010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NtRootA1_40020	COG0640	Transcriptional regulator
NtRootA1_40040	COG0123	including yeast histone deacetylase and acetoin utilization protein
NtRootA1_40050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NtRootA1_40060	COG0569	domain protein
NtRootA1_40070	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NtRootA1_40080	COG1082	Xylose isomerase domain protein TIM barrel
NtRootA1_40090	COG0248	Ppx GppA phosphatase
NtRootA1_40110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NtRootA1_40110	COG1754	DNA topoisomerase type I activity
NtRootA1_40130	COG2890	protein-(glutamine-N5) methyltransferase activity
NtRootA1_40160	COG1054	Belongs to the UPF0176 family
NtRootA1_40180	COG1111	helicase
NtRootA1_40180	COG1205	dead DEAH box helicase
NtRootA1_40320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NtRootA1_40330	COG1349	DNA-binding transcription factor activity
NtRootA1_40340	COG0577	efflux transmembrane transporter activity
NtRootA1_40340	COG1136	(ABC) transporter
NtRootA1_40360	COG1609	Transcriptional regulator
NtRootA1_40380	COG1175	transmembrane transport
NtRootA1_40390	COG0395	ABC-type sugar transport system, permease component
NtRootA1_40480	COG4499	WXG100 protein secretion system (Wss), protein YukC
NtRootA1_40480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NtRootA1_40490	COG1408	metallophosphoesterase
NtRootA1_40500	COG1132	(ABC) transporter
NtRootA1_40510	COG1132	(ABC) transporter
NtRootA1_40540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NtRootA1_40550	COG0151	Belongs to the GarS family
NtRootA1_40580	COG1301	dicarboxylic acid transport
NtRootA1_40590	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_40610	COG1953	Uracil, thiamine, allantoin
NtRootA1_40620	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NtRootA1_40650	COG2080	2 iron, 2 sulfur cluster binding
NtRootA1_40650	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NtRootA1_40670	COG3608	succinylglutamate desuccinylase aspartoacylase
NtRootA1_40670	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NtRootA1_40680	COG2252	PERMEase
NtRootA1_40690	COG0590	tRNA wobble adenosine to inosine editing
NtRootA1_40740	COG2233	PERMEase
NtRootA1_40760	COG1414	Transcriptional regulator
NtRootA1_40780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NtRootA1_40800	COG3257	ureidoglycine aminohydrolase activity
NtRootA1_40830	COG4585	Histidine kinase
NtRootA1_40840	COG4499	WXG100 protein secretion system (Wss), protein YukC
NtRootA1_40840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NtRootA1_40890	COG0659	secondary active sulfate transmembrane transporter activity
NtRootA1_40930	COG0563	adenylate kinase activity
NtRootA1_40970	COG3401	FG-GAP repeat protein
NtRootA1_41100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NtRootA1_41120	COG1733	regulation of RNA biosynthetic process
NtRootA1_41130	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NtRootA1_41180	COG2267	carboxylic ester hydrolase activity
NtRootA1_41290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NtRootA1_41300	COG1024	Enoyl-CoA hydratase
NtRootA1_41330	COG0405	Gamma-glutamyltransferase
NtRootA1_41380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NtRootA1_41430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NtRootA1_41480	COG0477	Major facilitator Superfamily
NtRootA1_41490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NtRootA1_41510	COG0583	DNA-binding transcription factor activity
NtRootA1_41570	COG0673	inositol 2-dehydrogenase activity
NtRootA1_41600	COG1653	transport
NtRootA1_41610	COG1609	Transcriptional regulator
NtRootA1_41620	COG1132	(ABC) transporter
NtRootA1_41650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NtRootA1_41650	COG2022	thiamine diphosphate biosynthetic process
NtRootA1_41660	COG0546	phosphoglycolate phosphatase activity
NtRootA1_41670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NtRootA1_41700	COG0673	inositol 2-dehydrogenase activity
NtRootA1_41710	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NtRootA1_41760	COG3622	Belongs to the hyi family
NtRootA1_41770	COG2084	Dehydrogenase
NtRootA1_41780	COG3960	tartronate-semialdehyde synthase activity
NtRootA1_41790	COG1929	Belongs to the glycerate kinase type-1 family
NtRootA1_41800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NtRootA1_41810	COG0745	RESPONSE REGULATOR receiver
NtRootA1_41830	COG0745	RESPONSE REGULATOR receiver
NtRootA1_41840	COG1215	transferase activity, transferring glycosyl groups
NtRootA1_41850	COG1366	Belongs to the anti-sigma-factor antagonist family
NtRootA1_41900	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NtRootA1_41910	COG0671	phosphoesterase, PA-phosphatase related
NtRootA1_41960	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NtRootA1_42010	COG0542	response to heat
NtRootA1_42060	COG3585	molybdate ion transport
NtRootA1_42100	COG3304	Inner membrane component domain
NtRootA1_42120	COG0135	phosphoribosylanthranilate isomerase activity
NtRootA1_42150	COG2076	Multidrug Resistance protein
NtRootA1_42160	COG0667	Aldo Keto reductase
NtRootA1_42220	COG0500	methyltransferase
NtRootA1_42240	COG1473	amidohydrolase
NtRootA1_42250	COG0477	Major facilitator Superfamily
NtRootA1_42260	COG2807	transmembrane transport
NtRootA1_42280	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NtRootA1_42430	COG1609	Transcriptional regulator
NtRootA1_42450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NtRootA1_42460	COG1653	transport
NtRootA1_42470	COG1175	transmembrane transport
NtRootA1_42480	COG0395	ABC-type sugar transport system, permease component
NtRootA1_42550	COG0789	Transcriptional regulator
NtRootA1_42560	COG0484	heat shock protein binding
NtRootA1_42570	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NtRootA1_42580	COG0443	Heat shock 70 kDa protein
NtRootA1_42600	COG3739	integral membrane protein
NtRootA1_42760	COG0436	Aminotransferase
NtRootA1_42810	COG0531	amino acid
NtRootA1_42840	COG3226	Transcriptional regulator
NtRootA1_42850	COG1280	lysine exporter protein (LysE YggA)
NtRootA1_42860	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_42880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NtRootA1_42900	COG0492	ferredoxin-NADP+ reductase activity
NtRootA1_42910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NtRootA1_42960	COG3848	Pyruvate phosphate dikinase
NtRootA1_42960	COG0574	Belongs to the PEP-utilizing enzyme family
NtRootA1_42970	COG2409	Drug exporters of the RND superfamily
NtRootA1_43000	COG3795	YCII-related domain
NtRootA1_43010	COG4941	Belongs to the sigma-70 factor family
NtRootA1_43020	COG0667	Aldo Keto reductase
NtRootA1_43050	COG1280	lysine exporter protein (LysE YggA)
NtRootA1_43060	COG1609	Transcriptional regulator
NtRootA1_43070	COG1957	nucleoside hydrolase
NtRootA1_43080	COG0477	Major facilitator Superfamily
NtRootA1_43090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NtRootA1_43110	COG1309	transcriptional regulator
NtRootA1_43140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NtRootA1_43170	COG0833	amino acid
NtRootA1_43180	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NtRootA1_43200	COG2986	histidine ammonia-lyase
NtRootA1_43260	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NtRootA1_43270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NtRootA1_43290	COG1122	ATPase activity
NtRootA1_43300	COG4721	ABC-type cobalt transport system, permease component
NtRootA1_43330	COG1320	monovalent cation:proton antiporter activity
NtRootA1_43340	COG2212	antiporter activity
NtRootA1_43350	COG1863	multisubunit Na H antiporter MnhE subunit
NtRootA1_43360	COG0651	ATP synthesis coupled electron transport
NtRootA1_43370	COG1006	Multisubunit Na H antiporter MnhC subunit
NtRootA1_43380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NtRootA1_43380	COG2111	Na H antiporter
NtRootA1_43420	COG0475	glutathione-regulated potassium exporter activity
NtRootA1_43430	COG0717	Belongs to the dCTP deaminase family
NtRootA1_43500	COG0583	DNA-binding transcription factor activity
NtRootA1_43540	COG1609	Transcriptional regulator
NtRootA1_43550	COG0673	inositol 2-dehydrogenase activity
NtRootA1_43600	COG1295	ribonuclease BN
NtRootA1_43620	COG2115	Belongs to the xylose isomerase family
NtRootA1_43630	COG1070	Carbohydrate kinase
NtRootA1_43640	COG1609	Transcriptional regulator
NtRootA1_43670	COG2160	L-arabinose isomerase activity
NtRootA1_43680	COG2017	converts alpha-aldose to the beta-anomer
NtRootA1_43700	COG3254	rhamnose metabolic process
NtRootA1_43720	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_43720	COG3347	Dehydrogenase
NtRootA1_43730	COG1070	Carbohydrate kinase
NtRootA1_43750	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NtRootA1_43830	COG3387	PFAM Glycoside hydrolase 15-related
NtRootA1_43840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA1_43850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NtRootA1_43920	COG0433	COG0433 Predicted ATPase
NtRootA1_43970	COG0776	regulation of translation
NtRootA1_44010	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NtRootA1_44020	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NtRootA1_44030	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NtRootA1_44040	COG1017	nitric oxide dioxygenase activity
NtRootA1_44040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NtRootA1_44120	COG1120	ATPase activity
NtRootA1_44130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootA1_44140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootA1_44230	COG3012	SEC-C Motif Domain Protein
NtRootA1_44260	COG0667	Aldo Keto reductase
NtRootA1_44360	COG2186	Transcriptional regulator
NtRootA1_44380	COG1027	Aspartate ammonia-lyase
NtRootA1_44410	COG3618	amidohydrolase
NtRootA1_44430	COG3254	rhamnose metabolic process
NtRootA1_44450	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootA1_44470	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_44510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NtRootA1_44580	COG4221	oxidoreductase activity
NtRootA1_44600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NtRootA1_44610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NtRootA1_44650	COG1914	H( )-stimulated, divalent metal cation uptake system
NtRootA1_44660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NtRootA1_44670	COG1609	Transcriptional regulator
NtRootA1_44780	COG0640	Transcriptional regulator
NtRootA1_44810	COG1414	Transcriptional regulator
NtRootA1_44830	COG0477	Major facilitator Superfamily
NtRootA1_44850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NtRootA1_44900	COG1760	l-serine dehydratase
NtRootA1_44940	COG0726	polysaccharide deacetylase
NtRootA1_44960	COG0281	malic enzyme
NtRootA1_44970	COG1309	transcriptional regulator
NtRootA1_45030	COG2211	Major facilitator Superfamily
NtRootA1_45050	COG0477	Major facilitator Superfamily
NtRootA1_45060	COG2986	histidine ammonia-lyase
NtRootA1_45070	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NtRootA1_45100	COG1174	glycine betaine transport
NtRootA1_45130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NtRootA1_45150	COG0477	Major facilitator Superfamily
NtRootA1_45160	COG2814	Major facilitator Superfamily
NtRootA1_45170	COG1846	Transcriptional regulator
NtRootA1_45250	COG1113	amino acid transport
NtRootA1_45260	COG0246	Mannitol dehydrogenase
NtRootA1_45270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NtRootA1_45270	COG2213	PTS system mannitol-specific
NtRootA1_45290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NtRootA1_45300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NtRootA1_45330	COG4608	Belongs to the ABC transporter superfamily
NtRootA1_45340	COG0444	Belongs to the ABC transporter superfamily
NtRootA1_45350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootA1_45360	COG0601	transmembrane transport
NtRootA1_45370	COG0747	negative chemotaxis
NtRootA1_45420	COG0596	Alpha beta hydrolase
NtRootA1_45440	COG1793	dna ligase
NtRootA1_45500	COG0686	Belongs to the AlaDH PNT family
NtRootA1_45560	COG0673	inositol 2-dehydrogenase activity
NtRootA1_45610	COG1309	transcriptional regulator
NtRootA1_45670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NtRootA1_45710	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA1_45720	COG0022	dehydrogenase e1 component
NtRootA1_45740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NtRootA1_45750	COG1950	PFAM Membrane protein of
NtRootA1_45780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NtRootA1_45790	COG0406	alpha-ribazole phosphatase activity
NtRootA1_45810	COG1607	acyl-coa hydrolase
NtRootA1_45840	COG3971	2-oxopent-4-enoate hydratase activity
NtRootA1_45870	COG1802	Transcriptional regulator
NtRootA1_45880	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA1_45920	COG2261	transglycosylase associated protein
NtRootA1_45940	COG3708	Transcriptional regulator
NtRootA1_45940	COG2207	Transcriptional regulator
NtRootA1_45960	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_46000	COG0477	Major facilitator Superfamily
NtRootA1_46020	COG1609	Transcriptional regulator
NtRootA1_46050	COG0395	ABC-type sugar transport system, permease component
NtRootA1_46070	COG5492	domain, Protein
NtRootA1_46110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NtRootA1_46140	COG0515	serine threonine protein kinase
NtRootA1_46140	COG2815	serine threonine protein kinase
NtRootA1_46240	COG3387	PFAM Glycoside hydrolase 15-related
NtRootA1_46260	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
NtRootA1_46370	COG2814	Major facilitator Superfamily
NtRootA1_46420	COG0243	molybdopterin cofactor binding
NtRootA1_46520	COG0515	serine threonine protein kinase
NtRootA1_46520	COG2815	serine threonine protein kinase
NtRootA1_46530	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NtRootA1_46540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NtRootA1_46550	COG1760	l-serine dehydratase
NtRootA1_46560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NtRootA1_46570	COG0509	glycine decarboxylation via glycine cleavage system
NtRootA1_46580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NtRootA1_46590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NtRootA1_46590	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NtRootA1_46620	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NtRootA1_46630	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA1_46650	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_46690	COG1970	mechanosensitive ion channel activity
NtRootA1_46710	COG2271	Major facilitator Superfamily
NtRootA1_46720	COG1802	Transcriptional regulator
NtRootA1_46740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NtRootA1_46840	COG0546	phosphoglycolate phosphatase activity
NtRootA1_46850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NtRootA1_46890	COG2814	Major facilitator Superfamily
NtRootA1_46940	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA1_46950	COG0251	oxidation-reduction process
NtRootA1_46970	COG1414	Transcriptional regulator
NtRootA1_46980	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NtRootA1_47000	COG0183	Belongs to the thiolase family
NtRootA1_47010	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NtRootA1_47050	COG3485	protocatechuate 3,4-dioxygenase
NtRootA1_47060	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NtRootA1_47060	COG1082	Xylose isomerase domain protein TIM barrel
NtRootA1_47070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NtRootA1_47080	COG1414	Transcriptional regulator
NtRootA1_47120	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NtRootA1_47150	COG0646	methionine synthase
NtRootA1_47150	COG1410	methionine synthase
NtRootA1_47160	COG3845	ABC transporter
NtRootA1_47220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NtRootA1_47230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA1_47260	COG0251	oxidation-reduction process
NtRootA1_47280	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA1_47290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NtRootA1_47300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA1_47370	COG2610	gluconate transmembrane transporter activity
NtRootA1_47390	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
NtRootA1_47430	COG1414	Transcriptional regulator
NtRootA1_47550	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NtRootA1_47580	COG0277	FAD linked oxidase domain protein
NtRootA1_47590	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NtRootA1_47600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NtRootA1_47670	COG0596	Alpha beta hydrolase
NtRootA1_47680	COG1937	Protein conserved in bacteria
NtRootA1_47770	COG0534	Mate efflux family protein
NtRootA1_47790	COG2259	Doxx family
NtRootA1_47820	COG3848	Pyruvate phosphate dikinase
NtRootA1_47820	COG0574	Belongs to the PEP-utilizing enzyme family
NtRootA1_47850	COG1607	acyl-coa hydrolase
NtRootA1_47880	COG0305	Participates in initiation and elongation during chromosome replication
NtRootA1_47960	COG2610	gluconate transmembrane transporter activity
NtRootA1_47970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NtRootA1_47980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NtRootA1_48020	COG1414	Transcriptional regulator
NtRootA1_48050	COG0359	binds to the 23S rRNA
NtRootA1_48060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NtRootA1_48080	COG0360	Binds together with S18 to 16S ribosomal RNA
NtRootA1_48110	COG1113	amino acid transport
NtRootA1_48120	COG1362	aminopeptidase activity
NtRootA1_48180	COG0833	amino acid
NtRootA1_48190	COG2197	response regulator
NtRootA1_48200	COG4585	Histidine kinase
NtRootA1_48220	COG1131	(ABC) transporter
NtRootA1_48230	COG1597	lipid kinase activity
NtRootA1_48250	COG0738	Major facilitator superfamily
NtRootA1_48270	COG0488	(ABC) transporter
NtRootA1_48310	COG2197	response regulator
NtRootA1_48320	COG4585	Histidine kinase
NtRootA1_48340	COG1136	(ABC) transporter
NtRootA1_48350	COG1733	regulation of RNA biosynthetic process
NtRootA1_48360	COG2910	NAD(P)H-binding
NtRootA1_48400	COG0406	alpha-ribazole phosphatase activity
NtRootA1_48410	COG0617	tRNA 3'-terminal CCA addition
NtRootA1_48450	COG0492	ferredoxin-NADP+ reductase activity
NtRootA1_48460	COG3118	belongs to the thioredoxin family
NtRootA1_48500	COG1192	Involved in chromosome partitioning
NtRootA1_48510	COG0357	Ribosomal RNA small subunit methyltransferase G
NtRootA1_48530	COG0706	membrane insertase activity
NtRootA1_48540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NtRootA1_48550	COG0594	ribonuclease P activity
NtRootA1_48560	COG0230	Belongs to the bacterial ribosomal protein bL34 family