locus-tag	class	description
NtRootA2_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NtRootA2_00020	COG0592	DNA-directed DNA polymerase activity
NtRootA2_00030	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NtRootA2_00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NtRootA2_00050	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
NtRootA2_00060	COG0187	DNA topoisomerase II activity
NtRootA2_00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NtRootA2_00090	COG3266	domain, Protein
NtRootA2_00110	COG1215	transferase activity, transferring glycosyl groups
NtRootA2_00140	COG0705	Rhomboid family
NtRootA2_00140	COG0457	Tetratricopeptide repeat
NtRootA2_00160	COG2818	Glycosylase
NtRootA2_00180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NtRootA2_00180	COG2169	Transcriptional regulator
NtRootA2_00190	COG1595	DNA-templated transcription, initiation
NtRootA2_00220	COG3764	Sortase (surface protein transpeptidase)
NtRootA2_00240	COG0515	serine threonine protein kinase
NtRootA2_00250	COG0515	serine threonine protein kinase
NtRootA2_00260	COG0768	penicillin binding
NtRootA2_00290	COG1716	ATPase activity
NtRootA2_00300	COG1716	ATPase activity
NtRootA2_00390	COG1960	acyl-CoA dehydrogenase activity
NtRootA2_00420	COG0477	Major facilitator Superfamily
NtRootA2_00430	COG2175	clavaminate synthase activity
NtRootA2_00500	COG0346	lactoylglutathione lyase activity
NtRootA2_00530	COG2186	Transcriptional regulator
NtRootA2_00540	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NtRootA2_00550	COG0477	Major facilitator Superfamily
NtRootA2_00560	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NtRootA2_00570	COG4770	biotin carboxylase activity
NtRootA2_00580	COG1940	carbohydrate kinase activity
NtRootA2_00590	COG1653	transport
NtRootA2_00620	COG0395	ABC-type sugar transport system, permease component
NtRootA2_00640	COG1940	carbohydrate kinase activity
NtRootA2_00650	COG3119	arylsulfatase activity
NtRootA2_00670	COG3142	Participates in the control of copper homeostasis
NtRootA2_00680	COG0277	FAD linked oxidase domain protein
NtRootA2_00700	COG1733	regulation of RNA biosynthetic process
NtRootA2_00720	COG0385	Bile acid
NtRootA2_00730	COG0659	secondary active sulfate transmembrane transporter activity
NtRootA2_00770	COG0435	Glutathione S-transferase
NtRootA2_00780	COG0561	phosphatase activity
NtRootA2_00820	COG0584	glycerophosphoryl diester phosphodiesterase
NtRootA2_00830	COG3250	beta-galactosidase activity
NtRootA2_00840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootA2_00850	COG1929	Belongs to the glycerate kinase type-1 family
NtRootA2_00950	COG2720	vancomycin resistance protein
NtRootA2_00980	COG2135	peptidase activity
NtRootA2_01010	COG0693	protein deglycase activity
NtRootA2_01030	COG1131	(ABC) transporter
NtRootA2_01050	COG2197	response regulator
NtRootA2_01060	COG4585	Histidine kinase
NtRootA2_01090	COG2233	PERMEase
NtRootA2_01110	COG0778	Nitroreductase
NtRootA2_01150	COG3104	oligopeptide transport
NtRootA2_01170	COG3340	Belongs to the peptidase S51 family
NtRootA2_01180	COG0425	Belongs to the sulfur carrier protein TusA family
NtRootA2_01180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NtRootA2_01210	COG1597	lipid kinase activity
NtRootA2_01220	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NtRootA2_01240	COG3973	AAA domain
NtRootA2_01250	COG0561	phosphatase activity
NtRootA2_01270	COG1191	sigma factor activity
NtRootA2_01410	COG0037	tRNA processing
NtRootA2_01440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NtRootA2_01450	COG0302	gtp cyclohydrolase
NtRootA2_01470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NtRootA2_01530	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NtRootA2_01550	COG2814	Major facilitator Superfamily
NtRootA2_01600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NtRootA2_01650	COG1506	peptidase
NtRootA2_01650	COG0823	Involved in the tonB-independent uptake of proteins
NtRootA2_01660	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NtRootA2_01690	COG2376	Dihydroxyacetone kinase
NtRootA2_01710	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
NtRootA2_01770	COG3707	response regulator
NtRootA2_01790	COG1301	dicarboxylic acid transport
NtRootA2_01830	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NtRootA2_01860	COG0671	phosphoesterase, PA-phosphatase related
NtRootA2_01910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NtRootA2_02030	COG1609	Transcriptional regulator
NtRootA2_02070	COG0831	urea catabolic process
NtRootA2_02080	COG0832	Belongs to the urease beta subunit family
NtRootA2_02090	COG0804	urea catabolic process
NtRootA2_02100	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NtRootA2_02110	COG0830	nickel cation binding
NtRootA2_02120	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NtRootA2_02130	COG0829	nickel cation binding
NtRootA2_02140	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
NtRootA2_02230	COG0656	L-ascorbic acid biosynthetic process
NtRootA2_02250	COG0667	Aldo Keto reductase
NtRootA2_02260	COG0656	L-ascorbic acid biosynthetic process
NtRootA2_02280	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA2_02290	COG3360	Dodecin
NtRootA2_02300	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_02330	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NtRootA2_02340	COG0028	Belongs to the TPP enzyme family
NtRootA2_02350	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NtRootA2_02360	COG1233	COG1233 Phytoene dehydrogenase and related
NtRootA2_02370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NtRootA2_02390	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_02420	COG2186	Transcriptional regulator
NtRootA2_02450	COG2084	Dehydrogenase
NtRootA2_02460	COG2610	gluconate transmembrane transporter activity
NtRootA2_02570	COG0076	glutamate decarboxylase activity
NtRootA2_02580	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NtRootA2_02670	COG1216	Glycosyl transferase, family 2
NtRootA2_02690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NtRootA2_02700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NtRootA2_02780	COG0346	lactoylglutathione lyase activity
NtRootA2_02800	COG0697	spore germination
NtRootA2_02810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NtRootA2_02820	COG2186	Transcriptional regulator
NtRootA2_02830	COG1653	transport
NtRootA2_02840	COG1175	transmembrane transport
NtRootA2_02860	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootA2_02890	COG0477	Major facilitator Superfamily
NtRootA2_02900	COG2890	protein-(glutamine-N5) methyltransferase activity
NtRootA2_02940	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NtRootA2_02950	COG0395	ABC-type sugar transport system, permease component
NtRootA2_02960	COG1175	transmembrane transport
NtRootA2_03070	COG3226	Transcriptional regulator
NtRootA2_03090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NtRootA2_03090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NtRootA2_03090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NtRootA2_03100	COG1105	Belongs to the carbohydrate kinase PfkB family
NtRootA2_03110	COG1349	DNA-binding transcription factor activity
NtRootA2_03160	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NtRootA2_03210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NtRootA2_03280	COG1846	Transcriptional regulator
NtRootA2_03340	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NtRootA2_03400	COG0129	dihydroxy-acid dehydratase activity
NtRootA2_03430	COG5006	permease, DMT superfamily
NtRootA2_03440	COG1609	Transcriptional regulator
NtRootA2_03450	COG0673	inositol 2-dehydrogenase activity
NtRootA2_03460	COG0673	inositol 2-dehydrogenase activity
NtRootA2_03480	COG0673	inositol 2-dehydrogenase activity
NtRootA2_03530	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NtRootA2_03540	COG1984	allophanate hydrolase subunit 2
NtRootA2_03560	COG2733	membrane
NtRootA2_03640	COG4122	O-methyltransferase activity
NtRootA2_03650	COG0454	-acetyltransferase
NtRootA2_03650	COG0456	acetyltransferase
NtRootA2_03680	COG1132	(ABC) transporter
NtRootA2_03700	COG2207	Transcriptional regulator
NtRootA2_03740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootA2_03750	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootA2_03760	COG1120	ATPase activity
NtRootA2_03770	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA2_03800	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_03810	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA2_03870	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NtRootA2_03910	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA2_03930	COG0010	Belongs to the arginase family
NtRootA2_03940	COG2252	PERMEase
NtRootA2_04000	COG0574	Belongs to the PEP-utilizing enzyme family
NtRootA2_04000	COG3848	Pyruvate phosphate dikinase
NtRootA2_04030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NtRootA2_04220	COG0640	Transcriptional regulator
NtRootA2_04250	COG2182	Extracellular solute-binding protein
NtRootA2_04290	COG1609	Transcriptional regulator
NtRootA2_04330	COG2197	response regulator
NtRootA2_04340	COG4585	Histidine kinase
NtRootA2_04360	COG0666	response to abiotic stimulus
NtRootA2_04370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NtRootA2_04390	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NtRootA2_04460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NtRootA2_04480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NtRootA2_04490	COG0303	'Molybdopterin
NtRootA2_04500	COG1063	alcohol dehydrogenase
NtRootA2_04520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NtRootA2_04530	COG3404	Formiminotransferase-cyclodeaminase
NtRootA2_04560	COG1802	Transcriptional regulator
NtRootA2_04570	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NtRootA2_04590	COG0583	DNA-binding transcription factor activity
NtRootA2_04620	COG2197	response regulator
NtRootA2_04670	COG0415	Belongs to the DNA photolyase family
NtRootA2_04700	COG1024	Enoyl-CoA hydratase
NtRootA2_04760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NtRootA2_04800	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA2_04840	COG0789	Transcriptional regulator
NtRootA2_04850	COG1695	Transcriptional regulator
NtRootA2_04880	COG1609	Transcriptional regulator
NtRootA2_04900	COG1175	transmembrane transport
NtRootA2_04910	COG0395	ABC-type sugar transport system, permease component
NtRootA2_04930	COG0673	inositol 2-dehydrogenase activity
NtRootA2_04950	COG1904	glucuronate isomerase
NtRootA2_04960	COG0246	Mannitol dehydrogenase
NtRootA2_04970	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootA2_04980	COG3265	gluconokinase activity
NtRootA2_04990	COG4213	ABC transporter substrate-binding protein
NtRootA2_05000	COG1129	ABC transporter
NtRootA2_05010	COG4214	carbohydrate transport
NtRootA2_05020	COG1609	Transcriptional regulator
NtRootA2_05030	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NtRootA2_05090	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA2_05110	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA2_05140	COG1120	ATPase activity
NtRootA2_05150	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootA2_05160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootA2_05170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NtRootA2_05240	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NtRootA2_05250	COG2205	protein histidine kinase activity
NtRootA2_05270	COG1309	transcriptional regulator
NtRootA2_05280	COG0477	Major facilitator Superfamily
NtRootA2_05290	COG3386	PFAM SMP-30 Gluconolaconase
NtRootA2_05320	COG0488	(ABC) transporter
NtRootA2_05360	COG0477	Major facilitator Superfamily
NtRootA2_05370	COG3263	regulation of cellular component size
NtRootA2_05380	COG5492	domain, Protein
NtRootA2_05380	COG4932	domain protein
NtRootA2_05430	COG1609	Transcriptional regulator
NtRootA2_05450	COG0765	amino acid transport
NtRootA2_05460	COG1126	abc transporter atp-binding protein
NtRootA2_05470	COG0673	inositol 2-dehydrogenase activity
NtRootA2_05570	COG1832	CoA-binding protein
NtRootA2_05600	COG2315	Protein conserved in bacteria
NtRootA2_05610	COG1653	transport
NtRootA2_05620	COG1175	transmembrane transport
NtRootA2_05630	COG0395	ABC-type sugar transport system, permease component
NtRootA2_05700	COG2368	4-hydroxyphenylacetate
NtRootA2_05780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NtRootA2_05790	COG3706	GGDEF domain
NtRootA2_05820	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NtRootA2_05830	COG0047	phosphoribosylformylglycinamidine synthase activity
NtRootA2_05870	COG3546	catalase activity
NtRootA2_05880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootA2_05940	COG1846	Transcriptional regulator
NtRootA2_05960	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA2_05980	COG5416	Lipopolysaccharide assembly protein A domain
NtRootA2_06050	COG2847	Copper chaperone PCu(A)C
NtRootA2_06060	COG2837	iron assimilation
NtRootA2_06110	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NtRootA2_06130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NtRootA2_06130	COG3323	Protein of unknown function (DUF1653)
NtRootA2_06150	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA2_06180	COG1846	Transcriptional regulator
NtRootA2_06240	COG0739	heme binding
NtRootA2_06240	COG0741	lytic transglycosylase activity
NtRootA2_06240	COG1196	nuclear chromosome segregation
NtRootA2_06250	COG0386	Belongs to the glutathione peroxidase family
NtRootA2_06260	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NtRootA2_06320	COG1609	Transcriptional regulator
NtRootA2_06340	COG1175	transmembrane transport
NtRootA2_06350	COG0395	ABC-type sugar transport system, permease component
NtRootA2_06380	COG0438	transferase activity, transferring glycosyl groups
NtRootA2_06430	COG1621	beta-fructofuranosidase activity
NtRootA2_06440	COG1609	Transcriptional regulator
NtRootA2_06450	COG0395	ABC-type sugar transport system, permease component
NtRootA2_06490	COG0589	response to stress
NtRootA2_06530	COG3290	protein histidine kinase activity
NtRootA2_06540	COG4565	transcriptional regulatory protein
NtRootA2_06550	COG4702	Belongs to the UPF0303 family
NtRootA2_06570	COG0823	Involved in the tonB-independent uptake of proteins
NtRootA2_06590	COG0673	inositol 2-dehydrogenase activity
NtRootA2_06600	COG0673	inositol 2-dehydrogenase activity
NtRootA2_06620	COG0395	ABC-type sugar transport system, permease component
NtRootA2_06690	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NtRootA2_06710	COG1476	TRANSCRIPTIONal
NtRootA2_06760	COG1309	transcriptional regulator
NtRootA2_06780	COG0351	phosphomethylpyrimidine kinase
NtRootA2_06800	COG0642	Histidine kinase
NtRootA2_06810	COG0745	RESPONSE REGULATOR receiver
NtRootA2_06820	COG0477	Major facilitator Superfamily
NtRootA2_06880	COG0343	queuine tRNA-ribosyltransferase activity
NtRootA2_06960	COG1960	acyl-CoA dehydrogenase activity
NtRootA2_07020	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NtRootA2_07040	COG0586	Pfam SNARE associated Golgi protein
NtRootA2_07060	COG0564	pseudouridine synthase activity
NtRootA2_07110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NtRootA2_07120	COG2364	Membrane
NtRootA2_07150	COG1215	transferase activity, transferring glycosyl groups
NtRootA2_07170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NtRootA2_07180	COG1201	RNA secondary structure unwinding
NtRootA2_07230	COG0569	domain protein
NtRootA2_07230	COG0475	glutathione-regulated potassium exporter activity
NtRootA2_07280	COG0438	transferase activity, transferring glycosyl groups
NtRootA2_07320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NtRootA2_07400	COG2205	protein histidine kinase activity
NtRootA2_07410	COG0745	RESPONSE REGULATOR receiver
NtRootA2_07430	COG2062	phosphohistidine phosphatase, SixA
NtRootA2_07440	COG0583	DNA-binding transcription factor activity
NtRootA2_07450	COG0697	spore germination
NtRootA2_07470	COG1309	transcriptional regulator
NtRootA2_07480	COG1511	domain protein
NtRootA2_07520	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
NtRootA2_07530	COG1940	carbohydrate kinase activity
NtRootA2_07550	COG4608	Belongs to the ABC transporter superfamily
NtRootA2_07560	COG0444	Belongs to the ABC transporter superfamily
NtRootA2_07570	COG0601	transmembrane transport
NtRootA2_07580	COG0747	negative chemotaxis
NtRootA2_07600	COG1309	transcriptional regulator
NtRootA2_07610	COG0477	Major facilitator Superfamily
NtRootA2_07620	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NtRootA2_07630	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA2_07640	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
NtRootA2_07650	COG1017	nitric oxide dioxygenase activity
NtRootA2_07650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NtRootA2_07700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NtRootA2_07710	COG0514	ATP-dependent DNA helicase (RecQ)
NtRootA2_07720	COG0477	Major facilitator Superfamily
NtRootA2_07730	COG1505	serine-type exopeptidase activity
NtRootA2_07750	COG1113	amino acid transport
NtRootA2_07790	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_07790	COG3321	synthase
NtRootA2_07790	COG0604	alcohol dehydrogenase
NtRootA2_07810	COG1966	Carbon starvation protein
NtRootA2_07850	COG0656	L-ascorbic acid biosynthetic process
NtRootA2_07890	COG0673	inositol 2-dehydrogenase activity
NtRootA2_07900	COG1172	Belongs to the binding-protein-dependent transport system permease family
NtRootA2_07940	COG1609	Transcriptional regulator
NtRootA2_07970	COG0154	amidase activity
NtRootA2_08010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NtRootA2_08070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NtRootA2_08080	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NtRootA2_08120	COG0588	phosphoglycerate mutase activity
NtRootA2_08180	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NtRootA2_08190	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NtRootA2_08210	COG0215	cysteine-tRNA ligase activity
NtRootA2_08290	COG0366	Alpha amylase catalytic
NtRootA2_08310	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NtRootA2_08340	COG1609	Transcriptional regulator
NtRootA2_08350	COG0366	Alpha amylase catalytic
NtRootA2_08380	COG3833	ABC-type maltose transport systems, permease component
NtRootA2_08390	COG0366	Alpha amylase catalytic
NtRootA2_08400	COG0277	FAD linked oxidase domain protein
NtRootA2_08430	COG0402	S-adenosylhomocysteine deaminase activity
NtRootA2_08440	COG4608	Belongs to the ABC transporter superfamily
NtRootA2_08450	COG0444	Belongs to the ABC transporter superfamily
NtRootA2_08460	COG0601	transmembrane transport
NtRootA2_08480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootA2_08490	COG0402	S-adenosylhomocysteine deaminase activity
NtRootA2_08530	COG3842	ATPase activity
NtRootA2_08630	COG0542	response to heat
NtRootA2_08640	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_08650	COG1609	Transcriptional regulator
NtRootA2_08660	COG0395	ABC-type sugar transport system, permease component
NtRootA2_08670	COG1175	transmembrane transport
NtRootA2_08680	COG1653	transport
NtRootA2_08700	COG1621	beta-fructofuranosidase activity
NtRootA2_08760	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NtRootA2_08780	COG3634	alkyl hydroperoxide reductase activity
NtRootA2_08830	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_08850	COG1960	acyl-CoA dehydrogenase activity
NtRootA2_08900	COG0579	oxidoreductase
NtRootA2_08950	COG2957	Belongs to the agmatine deiminase family
NtRootA2_08970	COG0024	Methionine aminopeptidase
NtRootA2_09000	COG0492	ferredoxin-NADP+ reductase activity
NtRootA2_09040	COG0477	Major facilitator Superfamily
NtRootA2_09060	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NtRootA2_09060	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NtRootA2_09070	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NtRootA2_09080	COG0509	glycine decarboxylation via glycine cleavage system
NtRootA2_09090	COG1760	l-serine dehydratase
NtRootA2_09100	COG1864	DNA RNA non-specific endonuclease
NtRootA2_09100	COG3591	Belongs to the peptidase S1B family
NtRootA2_09190	COG0459	protein refolding
NtRootA2_09200	COG0328	RNA-DNA hybrid ribonuclease activity
NtRootA2_09220	COG2205	protein histidine kinase activity
NtRootA2_09230	COG0745	RESPONSE REGULATOR receiver
NtRootA2_09250	COG0583	DNA-binding transcription factor activity
NtRootA2_09270	COG2132	Multicopper oxidase
NtRootA2_09320	COG1278	Cold shock
NtRootA2_09340	COG2814	Major facilitator Superfamily
NtRootA2_09350	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NtRootA2_09370	COG0739	heme binding
NtRootA2_09380	COG0791	NLP P60 protein
NtRootA2_09380	COG3103	Sh3 type 3 domain protein
NtRootA2_09380	COG1388	LysM domain
NtRootA2_09410	COG0746	molybdenum cofactor guanylyltransferase activity
NtRootA2_09440	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NtRootA2_09480	COG1126	abc transporter atp-binding protein
NtRootA2_09490	COG0765	amino acid transport
NtRootA2_09500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA2_09530	COG0488	(ABC) transporter
NtRootA2_09540	COG1132	(ABC) transporter
NtRootA2_09550	COG0494	nUDIX hydrolase
NtRootA2_09620	COG0483	inositol monophosphate 1-phosphatase activity
NtRootA2_09760	COG0045	succinate-CoA ligase (ADP-forming) activity
NtRootA2_09790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NtRootA2_09810	COG3962	Belongs to the TPP enzyme family
NtRootA2_09840	COG0673	inositol 2-dehydrogenase activity
NtRootA2_09850	COG1082	Xylose isomerase domain protein TIM barrel
NtRootA2_09860	COG3718	enzyme involved in inositol metabolism
NtRootA2_09870	COG2188	Transcriptional regulator
NtRootA2_09890	COG1172	Belongs to the binding-protein-dependent transport system permease family
NtRootA2_09940	COG0673	inositol 2-dehydrogenase activity
NtRootA2_10040	COG1396	sequence-specific DNA binding
NtRootA2_10080	COG0028	Belongs to the TPP enzyme family
NtRootA2_10090	COG0477	Major facilitator Superfamily
NtRootA2_10100	COG1234	tRNA 3'-trailer cleavage
NtRootA2_10110	COG0583	DNA-binding transcription factor activity
NtRootA2_10170	COG3142	Participates in the control of copper homeostasis
NtRootA2_10220	COG1401	restriction endodeoxyribonuclease activity
NtRootA2_10250	COG5002	protein histidine kinase activity
NtRootA2_10260	COG0745	RESPONSE REGULATOR receiver
NtRootA2_10280	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA2_10310	COG1024	Enoyl-CoA hydratase
NtRootA2_10320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NtRootA2_10340	COG0477	Major facilitator Superfamily
NtRootA2_10350	COG1396	sequence-specific DNA binding
NtRootA2_10380	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NtRootA2_10400	COG3237	CsbD-like
NtRootA2_10410	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_10420	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_10460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NtRootA2_10480	COG1902	pentaerythritol trinitrate reductase activity
NtRootA2_10510	COG2376	Dihydroxyacetone kinase
NtRootA2_10520	COG0698	ribose 5-phosphate isomerase
NtRootA2_10530	COG1250	3-hydroxyacyl-CoA dehydrogenase
NtRootA2_10540	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_10550	COG2271	Major facilitator Superfamily
NtRootA2_10560	COG0149	triose-phosphate isomerase activity
NtRootA2_10640	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NtRootA2_10660	COG1254	Belongs to the acylphosphatase family
NtRootA2_10670	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
NtRootA2_10690	COG1309	transcriptional regulator
NtRootA2_10710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NtRootA2_10720	COG2186	Transcriptional regulator
NtRootA2_10730	COG0477	Major facilitator Superfamily
NtRootA2_10750	COG0640	Transcriptional regulator
NtRootA2_10770	COG4209	transmembrane transport
NtRootA2_10780	COG0395	ABC-type sugar transport system, permease component
NtRootA2_10790	COG1653	transport
NtRootA2_10890	COG1472	Belongs to the glycosyl hydrolase 3 family
NtRootA2_10900	COG0673	inositol 2-dehydrogenase activity
NtRootA2_10930	COG1609	Transcriptional regulator
NtRootA2_10970	COG0477	Major facilitator Superfamily
NtRootA2_11040	COG0640	Transcriptional regulator
NtRootA2_11070	COG1846	Transcriptional regulator
NtRootA2_11080	COG0697	spore germination
NtRootA2_11180	COG2072	flavoprotein involved in K transport
NtRootA2_11210	COG1278	Cold shock
NtRootA2_11230	COG1131	(ABC) transporter
NtRootA2_11300	COG1846	Transcriptional regulator
NtRootA2_11340	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NtRootA2_11360	COG0789	Transcriptional regulator
NtRootA2_11380	COG0484	heat shock protein binding
NtRootA2_11430	COG2271	Major facilitator Superfamily
NtRootA2_11440	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NtRootA2_11480	COG0138	bifunctional purine biosynthesis protein purh
NtRootA2_11500	COG2838	Isocitrate dehydrogenase
NtRootA2_11520	COG3639	organic phosphonate transmembrane transporter activity
NtRootA2_11530	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NtRootA2_11560	COG2188	Transcriptional regulator
NtRootA2_11590	COG0673	inositol 2-dehydrogenase activity
NtRootA2_11600	COG1136	(ABC) transporter
NtRootA2_11620	COG4213	ABC transporter substrate-binding protein
NtRootA2_11640	COG1129	ABC transporter
NtRootA2_11660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NtRootA2_11680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NtRootA2_11700	COG0531	amino acid
NtRootA2_11760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NtRootA2_11770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NtRootA2_11780	COG1131	(ABC) transporter
NtRootA2_11820	COG0708	Exodeoxyribonuclease III
NtRootA2_11830	COG0180	Tryptophanyl-tRNA synthetase
NtRootA2_11900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NtRootA2_11930	COG2009	succinate dehydrogenase
NtRootA2_11950	COG1473	amidohydrolase
NtRootA2_11950	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NtRootA2_11960	COG1846	Transcriptional regulator
NtRootA2_11970	COG1764	response to oxidative stress
NtRootA2_11980	COG2130	NADP-dependent
NtRootA2_11990	COG1744	ABC transporter substrate-binding protein PnrA-like
NtRootA2_12000	COG3845	ABC transporter
NtRootA2_12010	COG4603	Belongs to the binding-protein-dependent transport system permease family
NtRootA2_12020	COG1079	Belongs to the binding-protein-dependent transport system permease family
NtRootA2_12060	COG0586	Pfam SNARE associated Golgi protein
NtRootA2_12070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NtRootA2_12080	COG3956	TIGRFAM MazG family protein
NtRootA2_12090	COG0148	phosphopyruvate hydratase activity
NtRootA2_12140	COG1252	NADH dehydrogenase
NtRootA2_12190	COG2205	protein histidine kinase activity
NtRootA2_12200	COG0745	RESPONSE REGULATOR receiver
NtRootA2_12230	COG0577	efflux transmembrane transporter activity
NtRootA2_12230	COG1136	(ABC) transporter
NtRootA2_12240	COG0577	efflux transmembrane transporter activity
NtRootA2_12240	COG1136	(ABC) transporter
NtRootA2_12300	COG0559	Belongs to the binding-protein-dependent transport system permease family
NtRootA2_12320	COG0183	Belongs to the thiolase family
NtRootA2_12330	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NtRootA2_12350	COG2017	converts alpha-aldose to the beta-anomer
NtRootA2_12370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NtRootA2_12390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NtRootA2_12410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NtRootA2_12440	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NtRootA2_12450	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NtRootA2_12520	COG0114	fumarate hydratase activity
NtRootA2_12530	COG0288	reversible hydration of carbon dioxide
NtRootA2_12550	COG1494	fructose-1,6-bisphosphatase
NtRootA2_12570	COG1482	cell wall glycoprotein biosynthetic process
NtRootA2_12690	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NtRootA2_12700	COG1376	ErfK ybiS ycfS ynhG family protein
NtRootA2_12710	COG1357	PFAM Pentapeptide repeats (8 copies)
NtRootA2_12810	COG0714	Associated with various cellular activities
NtRootA2_12820	COG0084	hydrolase, TatD family'
NtRootA2_12830	COG3583	domain protein
NtRootA2_12840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NtRootA2_12850	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NtRootA2_12860	COG0488	(ABC) transporter
NtRootA2_12880	COG1309	transcriptional regulator
NtRootA2_12890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NtRootA2_12900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NtRootA2_12910	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NtRootA2_12920	COG0193	aminoacyl-tRNA hydrolase activity
NtRootA2_12970	COG0822	iron-sulfur transferase activity
NtRootA2_12980	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NtRootA2_13010	COG0702	epimerase
NtRootA2_13030	COG1988	membrane-bound metal-dependent
NtRootA2_13050	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NtRootA2_13070	COG0446	pyridine nucleotide-disulphide oxidoreductase
NtRootA2_13160	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_13200	COG1609	Transcriptional regulator
NtRootA2_13210	COG2814	Major facilitator Superfamily
NtRootA2_13230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NtRootA2_13260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NtRootA2_13280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NtRootA2_13290	COG1621	beta-fructofuranosidase activity
NtRootA2_13350	COG0243	molybdopterin cofactor binding
NtRootA2_13360	COG2223	nitrite transmembrane transporter activity
NtRootA2_13370	COG0477	Major facilitator Superfamily
NtRootA2_13380	COG4770	biotin carboxylase activity
NtRootA2_13390	COG0424	maF-like protein
NtRootA2_13400	COG2409	Drug exporters of the RND superfamily
NtRootA2_13410	COG1309	transcriptional regulator
NtRootA2_13420	COG0393	Putative heavy-metal-binding
NtRootA2_13430	COG1823	symporter activity
NtRootA2_13460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NtRootA2_13470	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_13480	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NtRootA2_13480	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NtRootA2_13530	COG0714	Associated with various cellular activities
NtRootA2_13570	COG0631	protein serine/threonine phosphatase activity
NtRootA2_13610	COG1674	ftsk spoiiie
NtRootA2_13620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NtRootA2_13630	COG0483	inositol monophosphate 1-phosphatase activity
NtRootA2_13650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA2_13690	COG4565	transcriptional regulatory protein
NtRootA2_13710	COG2851	Citrate transporter
NtRootA2_13720	COG1316	TRANSCRIPTIONal
NtRootA2_13740	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NtRootA2_13750	COG0154	amidase activity
NtRootA2_13760	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NtRootA2_13780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NtRootA2_13790	COG4209	transmembrane transport
NtRootA2_13800	COG0395	ABC-type sugar transport system, permease component
NtRootA2_13840	COG0583	DNA-binding transcription factor activity
NtRootA2_13850	COG1063	alcohol dehydrogenase
NtRootA2_13860	COG0156	8-amino-7-oxononanoate synthase activity
NtRootA2_13880	COG1228	amidohydrolase
NtRootA2_13890	COG0366	Alpha amylase catalytic
NtRootA2_13890	COG1470	cell adhesion involved in biofilm formation
NtRootA2_13900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NtRootA2_13950	COG0588	phosphoglycerate mutase activity
NtRootA2_13980	COG2873	o-acetylhomoserine
NtRootA2_13990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NtRootA2_14060	COG0423	glycine-tRNA ligase activity
NtRootA2_14100	COG0390	transport system, permease component
NtRootA2_14110	COG2205	protein histidine kinase activity
NtRootA2_14130	COG0586	Pfam SNARE associated Golgi protein
NtRootA2_14140	COG0671	phosphoesterase, PA-phosphatase related
NtRootA2_14160	COG1131	(ABC) transporter
NtRootA2_14170	COG0842	Transport permease protein
NtRootA2_14180	COG4585	Histidine kinase
NtRootA2_14190	COG2197	response regulator
NtRootA2_14220	COG0358	DNA primase activity
NtRootA2_14240	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NtRootA2_14250	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NtRootA2_14270	COG2814	Major facilitator Superfamily
NtRootA2_14310	COG0297	glycogen (starch) synthase activity
NtRootA2_14340	COG0052	Belongs to the universal ribosomal protein uS2 family
NtRootA2_14350	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NtRootA2_14360	COG0528	UMP kinase activity
NtRootA2_14370	COG0233	cytoplasmic translational termination
NtRootA2_14380	COG0575	Belongs to the CDS family
NtRootA2_14410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NtRootA2_14430	COG3279	Response regulator of the LytR AlgR family
NtRootA2_14440	COG3275	phosphorelay sensor kinase activity
NtRootA2_14460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NtRootA2_14470	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NtRootA2_14470	COG1796	DNA polymerase
NtRootA2_14510	COG1522	sequence-specific DNA binding
NtRootA2_14530	COG0022	dehydrogenase e1 component
NtRootA2_14540	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA2_14550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NtRootA2_14580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NtRootA2_14600	COG1960	acyl-CoA dehydrogenase activity
NtRootA2_14650	COG0673	inositol 2-dehydrogenase activity
NtRootA2_14680	COG0673	inositol 2-dehydrogenase activity
NtRootA2_14700	COG1175	transmembrane transport
NtRootA2_14710	COG1653	transport
NtRootA2_14720	COG1609	Transcriptional regulator
NtRootA2_14740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NtRootA2_14750	COG0750	zinc metalloprotease
NtRootA2_14770	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NtRootA2_14800	COG1309	transcriptional regulator
NtRootA2_14840	COG0442	prolyl-tRNA aminoacylation
NtRootA2_14890	COG0779	Required for maturation of 30S ribosomal subunits
NtRootA2_14920	COG0481	GTPase activity
NtRootA2_14920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NtRootA2_14930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NtRootA2_14940	COG0590	tRNA wobble adenosine to inosine editing
NtRootA2_14960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NtRootA2_15000	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NtRootA2_15010	COG1185	polyribonucleotide nucleotidyltransferase activity
NtRootA2_15020	COG0612	Peptidase, M16
NtRootA2_15060	COG0745	RESPONSE REGULATOR receiver
NtRootA2_15070	COG2205	protein histidine kinase activity
NtRootA2_15110	COG0521	Mo-molybdopterin cofactor biosynthetic process
NtRootA2_15130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NtRootA2_15170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NtRootA2_15180	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NtRootA2_15190	COG1674	ftsk spoiiie
NtRootA2_15210	COG1546	Belongs to the CinA family
NtRootA2_15210	COG1058	Belongs to the CinA family
NtRootA2_15220	COG1396	sequence-specific DNA binding
NtRootA2_15250	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NtRootA2_15260	COG2137	regulation of response to DNA damage stimulus
NtRootA2_15270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NtRootA2_15280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NtRootA2_15290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NtRootA2_15300	COG2813	Specifically methylates the guanine in position
NtRootA2_15310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NtRootA2_15330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NtRootA2_15340	COG1388	LysM domain
NtRootA2_15360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NtRootA2_15370	COG0131	Imidazoleglycerol-phosphate dehydratase
NtRootA2_15380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NtRootA2_15400	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NtRootA2_15450	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NtRootA2_15460	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NtRootA2_15470	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NtRootA2_15480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NtRootA2_15500	COG2814	Major facilitator Superfamily
NtRootA2_15580	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NtRootA2_15590	COG0072	phenylalanine-tRNA ligase activity
NtRootA2_15590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NtRootA2_15600	COG3591	Belongs to the peptidase S1B family
NtRootA2_15670	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NtRootA2_15680	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NtRootA2_15690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NtRootA2_15700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NtRootA2_15710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NtRootA2_15720	COG1438	arginine binding
NtRootA2_15730	COG0137	argininosuccinate synthase activity
NtRootA2_15740	COG0165	Argininosuccinate lyase
NtRootA2_15770	COG2094	Belongs to the DNA glycosylase MPG family
NtRootA2_15790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NtRootA2_15820	COG0647	UMP catabolic process
NtRootA2_15850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NtRootA2_15860	COG0497	DNA recombination
NtRootA2_15870	COG0504	CTP synthase activity
NtRootA2_15940	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NtRootA2_15950	COG2079	MmgE PrpD family protein
NtRootA2_15980	COG3290	protein histidine kinase activity
NtRootA2_15990	COG1301	dicarboxylic acid transport
NtRootA2_16010	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NtRootA2_16020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NtRootA2_16050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NtRootA2_16070	COG1160	GTP binding
NtRootA2_16090	COG2814	Major facilitator Superfamily
NtRootA2_16110	COG0509	glycine decarboxylation via glycine cleavage system
NtRootA2_16120	COG1716	ATPase activity
NtRootA2_16170	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NtRootA2_16190	COG1940	carbohydrate kinase activity
NtRootA2_16240	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NtRootA2_16250	COG0515	serine threonine protein kinase
NtRootA2_16250	COG2815	serine threonine protein kinase
NtRootA2_16260	COG1388	LysM domain
NtRootA2_16260	COG3942	CHAP domain
NtRootA2_16290	COG0142	geranyltranstransferase activity
NtRootA2_16320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NtRootA2_16340	COG2001	Belongs to the MraZ family
NtRootA2_16350	COG0275	rRNA processing
NtRootA2_16370	COG0768	penicillin binding
NtRootA2_16380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NtRootA2_16400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NtRootA2_16410	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NtRootA2_16430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NtRootA2_16440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NtRootA2_16460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NtRootA2_16480	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NtRootA2_16490	COG1799	cell septum assembly
NtRootA2_16520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NtRootA2_16570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NtRootA2_16580	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NtRootA2_16590	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_16630	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NtRootA2_16640	COG0174	glutamine synthetase
NtRootA2_16650	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NtRootA2_16720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NtRootA2_16730	COG0321	lipoyl(octanoyl) transferase activity
NtRootA2_16740	COG0515	serine threonine protein kinase
NtRootA2_16740	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NtRootA2_16760	COG0793	Belongs to the peptidase S41A family
NtRootA2_16760	COG4946	Tricorn protease homolog
NtRootA2_16770	COG1764	response to oxidative stress
NtRootA2_16800	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA2_16810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NtRootA2_16820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NtRootA2_16870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NtRootA2_16930	COG1271	oxidase subunit
NtRootA2_16940	COG1294	oxidase, subunit
NtRootA2_16950	COG4988	ABC transporter
NtRootA2_16990	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NtRootA2_17000	COG0045	succinate-CoA ligase (ADP-forming) activity
NtRootA2_17000	COG1042	CoA-binding domain protein
NtRootA2_17000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NtRootA2_17030	COG1435	thymidine kinase activity
NtRootA2_17080	COG0756	dUTP diphosphatase activity
NtRootA2_17130	COG0569	domain protein
NtRootA2_17140	COG0531	amino acid
NtRootA2_17150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NtRootA2_17160	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NtRootA2_17170	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NtRootA2_17210	COG0667	Aldo Keto reductase
NtRootA2_17220	COG1250	3-hydroxyacyl-CoA dehydrogenase
NtRootA2_17220	COG1024	Enoyl-CoA hydratase
NtRootA2_17230	COG0183	Belongs to the thiolase family
NtRootA2_17290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NtRootA2_17320	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NtRootA2_17350	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NtRootA2_17360	COG3135	benzoate transporter
NtRootA2_17380	COG0531	amino acid
NtRootA2_17400	COG0242	peptide deformylase activity
NtRootA2_17410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NtRootA2_17430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NtRootA2_17470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NtRootA2_17470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NtRootA2_17490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NtRootA2_17500	COG0140	phosphoribosyl-ATP diphosphatase activity
NtRootA2_17510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NtRootA2_17520	COG0107	imidazoleglycerol-phosphate synthase activity
NtRootA2_17540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NtRootA2_17580	COG0134	indole-3-glycerol-phosphate synthase activity
NtRootA2_17590	COG0133	tryptophan synthase activity
NtRootA2_17600	COG0159	tryptophan synthase activity
NtRootA2_17610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NtRootA2_17620	COG0069	glutamate synthase activity
NtRootA2_17620	COG0070	glutamate synthase
NtRootA2_17620	COG0067	glutamate synthase
NtRootA2_17700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NtRootA2_17710	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA2_17720	COG0145	ligase activity
NtRootA2_17760	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA2_17770	COG0673	inositol 2-dehydrogenase activity
NtRootA2_17780	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_17790	COG0129	dihydroxy-acid dehydratase activity
NtRootA2_17800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootA2_17820	COG0673	inositol 2-dehydrogenase activity
NtRootA2_17840	COG1129	ABC transporter
NtRootA2_17850	COG1172	Belongs to the binding-protein-dependent transport system permease family
NtRootA2_17870	COG0247	lactate metabolic process
NtRootA2_17870	COG0277	FAD linked oxidase domain protein
NtRootA2_17930	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NtRootA2_17960	COG0800	Aldolase
NtRootA2_17980	COG1609	Transcriptional regulator
NtRootA2_18050	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_18070	COG0395	ABC-type sugar transport system, permease component
NtRootA2_18100	COG1760	l-serine dehydratase
NtRootA2_18130	COG2814	Major facilitator Superfamily
NtRootA2_18170	COG1733	regulation of RNA biosynthetic process
NtRootA2_18260	COG0443	Heat shock 70 kDa protein
NtRootA2_18270	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NtRootA2_18300	COG0542	response to heat
NtRootA2_18330	COG0747	negative chemotaxis
NtRootA2_18340	COG0601	transmembrane transport
NtRootA2_18350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootA2_18360	COG0444	Belongs to the ABC transporter superfamily
NtRootA2_18370	COG4608	Belongs to the ABC transporter superfamily
NtRootA2_18390	COG1621	beta-fructofuranosidase activity
NtRootA2_18420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NtRootA2_18430	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_18450	COG0251	oxidation-reduction process
NtRootA2_18500	COG1802	Transcriptional regulator
NtRootA2_18520	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NtRootA2_18540	COG1126	abc transporter atp-binding protein
NtRootA2_18550	COG0765	amino acid transport
NtRootA2_18560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA2_18580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NtRootA2_18590	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA2_18600	COG0473	3-isopropylmalate dehydrogenase activity
NtRootA2_18630	COG1064	alcohol dehydrogenase
NtRootA2_18640	COG0747	negative chemotaxis
NtRootA2_18660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootA2_18670	COG4172	Belongs to the ABC transporter superfamily
NtRootA2_18680	COG1309	transcriptional regulator
NtRootA2_18700	COG0604	alcohol dehydrogenase
NtRootA2_18700	COG3321	synthase
NtRootA2_18860	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NtRootA2_18920	COG1063	alcohol dehydrogenase
NtRootA2_18930	COG2217	Heavy metal translocating P-type atpase
NtRootA2_18950	COG0857	belongs to the CobB CobQ family
NtRootA2_18950	COG0280	phosphate acetyltransferase
NtRootA2_18960	COG0589	response to stress
NtRootA2_18970	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NtRootA2_19000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NtRootA2_19010	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NtRootA2_19030	COG0464	growth
NtRootA2_19160	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA2_19210	COG2828	Protein conserved in bacteria
NtRootA2_19230	COG0673	inositol 2-dehydrogenase activity
NtRootA2_19250	COG0395	ABC-type sugar transport system, permease component
NtRootA2_19280	COG1609	Transcriptional regulator
NtRootA2_19300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NtRootA2_19310	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootA2_19320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NtRootA2_19340	COG0475	glutathione-regulated potassium exporter activity
NtRootA2_19370	COG0028	Belongs to the TPP enzyme family
NtRootA2_19400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NtRootA2_19500	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA2_19510	COG2084	Dehydrogenase
NtRootA2_19520	COG1737	Transcriptional regulator
NtRootA2_19540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NtRootA2_19560	COG3795	YCII-related domain
NtRootA2_19570	COG4941	Belongs to the sigma-70 factor family
NtRootA2_19600	COG1064	alcohol dehydrogenase
NtRootA2_19610	COG1643	Atp-dependent helicase
NtRootA2_19620	COG1228	amidohydrolase
NtRootA2_19690	COG0009	L-threonylcarbamoyladenylate synthase
NtRootA2_19730	COG2971	BadF BadG BcrA BcrD
NtRootA2_19750	COG1414	Transcriptional regulator
NtRootA2_19770	COG1053	succinate dehydrogenase
NtRootA2_19790	COG0477	Major facilitator Superfamily
NtRootA2_19820	COG3483	tryptophan 2,3-dioxygenase activity
NtRootA2_19890	COG2050	protein possibly involved in aromatic compounds catabolism
NtRootA2_19910	COG4552	Acetyltransferase involved in intracellular survival and related
NtRootA2_19930	COG0539	negative regulation of cytoplasmic translation
NtRootA2_19940	COG1739	Uncharacterized protein family UPF0029
NtRootA2_19950	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NtRootA2_19950	COG0237	dephospho-CoA kinase activity
NtRootA2_19960	COG0556	nucleotide-excision repair
NtRootA2_19980	COG0477	Major facilitator Superfamily
NtRootA2_20000	COG0456	acetyltransferase
NtRootA2_20010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NtRootA2_20030	COG4106	trans-aconitate 2-methyltransferase activity
NtRootA2_20060	COG0546	phosphoglycolate phosphatase activity
NtRootA2_20080	COG0322	excinuclease ABC activity
NtRootA2_20090	COG1660	Displays ATPase and GTPase activities
NtRootA2_20110	COG1481	regulation of sporulation
NtRootA2_20120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NtRootA2_20130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NtRootA2_20140	COG0126	phosphoglycerate kinase activity
NtRootA2_20150	COG0149	triose-phosphate isomerase activity
NtRootA2_20160	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NtRootA2_20180	COG0363	glucosamine-6-phosphate deaminase activity
NtRootA2_20210	COG0166	Belongs to the GPI family
NtRootA2_20220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NtRootA2_20240	COG0109	protoheme IX farnesyltransferase activity
NtRootA2_20280	COG0577	efflux transmembrane transporter activity
NtRootA2_20280	COG1136	(ABC) transporter
NtRootA2_20290	COG1612	heme a metabolic process
NtRootA2_20300	COG0842	Transport permease protein
NtRootA2_20310	COG1131	(ABC) transporter
NtRootA2_20340	COG0719	Fe-S assembly protein
NtRootA2_20360	COG0396	ATPase activity
NtRootA2_20370	COG2151	metal-sulfur cluster biosynthetic enzyme
NtRootA2_20390	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootA2_20420	COG1122	ATPase activity
NtRootA2_20430	COG1268	BioY protein
NtRootA2_20440	COG0488	(ABC) transporter
NtRootA2_20490	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_20500	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_20510	COG1129	ABC transporter
NtRootA2_20540	COG0560	Phosphoserine phosphatase
NtRootA2_20540	COG3830	Belongs to the UPF0237 family
NtRootA2_20550	COG1119	ATPase activity
NtRootA2_20580	COG0254	rRNA binding
NtRootA2_20590	COG0095	Lipoate-protein ligase
NtRootA2_20630	COG2855	membrane
NtRootA2_20690	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NtRootA2_20700	COG0297	glycogen (starch) synthase activity
NtRootA2_20730	COG0183	Belongs to the thiolase family
NtRootA2_20760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NtRootA2_20800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NtRootA2_20810	COG0673	inositol 2-dehydrogenase activity
NtRootA2_20820	COG1088	dTDP-glucose 4,6-dehydratase activity
NtRootA2_20830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NtRootA2_20960	COG1088	dTDP-glucose 4,6-dehydratase activity
NtRootA2_20970	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NtRootA2_20980	COG0667	Aldo Keto reductase
NtRootA2_20990	COG1968	undecaprenyl-diphosphatase activity
NtRootA2_21000	COG0215	cysteine-tRNA ligase activity
NtRootA2_21020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NtRootA2_21030	COG0517	IMP dehydrogenase activity
NtRootA2_21030	COG1994	Peptidase M50
NtRootA2_21050	COG1222	aaa ATPase
NtRootA2_21060	COG4122	O-methyltransferase activity
NtRootA2_21080	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NtRootA2_21090	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NtRootA2_21100	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NtRootA2_21110	COG0545	Peptidyl-prolyl cis-trans isomerase
NtRootA2_21150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NtRootA2_21160	COG0805	protein transport
NtRootA2_21170	COG4581	dead DEAH box helicase
NtRootA2_21180	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NtRootA2_21190	COG1216	Glycosyl transferase, family 2
NtRootA2_21240	COG4946	Tricorn protease homolog
NtRootA2_21240	COG1506	peptidase
NtRootA2_21240	COG0823	Involved in the tonB-independent uptake of proteins
NtRootA2_21250	COG0242	peptide deformylase activity
NtRootA2_21290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NtRootA2_21300	COG3424	synthase
NtRootA2_21310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NtRootA2_21390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NtRootA2_21400	COG1845	cytochrome c oxidase, subunit III
NtRootA2_21410	COG2010	Cytochrome c
NtRootA2_21420	COG0723	plastoquinol--plastocyanin reductase activity
NtRootA2_21430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NtRootA2_21460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NtRootA2_21480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NtRootA2_21490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NtRootA2_21530	COG0167	dihydroorotate dehydrogenase activity
NtRootA2_21570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NtRootA2_21580	COG1381	Involved in DNA repair and RecF pathway recombination
NtRootA2_21590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NtRootA2_21600	COG3590	peptidase
NtRootA2_21610	COG1316	TRANSCRIPTIONal
NtRootA2_21620	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NtRootA2_21640	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NtRootA2_21680	COG0484	heat shock protein binding
NtRootA2_21690	COG1420	regulation of RNA biosynthetic process
NtRootA2_21720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NtRootA2_21730	COG0481	GTPase activity
NtRootA2_21750	COG0268	Binds directly to 16S ribosomal RNA
NtRootA2_21800	COG1307	EDD domain protein, DegV family
NtRootA2_21810	COG0495	leucyl-tRNA aminoacylation
NtRootA2_21820	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NtRootA2_21830	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NtRootA2_21840	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NtRootA2_21860	COG2390	Transcriptional regulator
NtRootA2_21870	COG0656	L-ascorbic acid biosynthetic process
NtRootA2_21890	COG0438	transferase activity, transferring glycosyl groups
NtRootA2_21910	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NtRootA2_21930	COG1758	RNA polymerase activity
NtRootA2_21940	COG0194	GDP metabolic process
NtRootA2_21960	COG0284	orotidine-5'-phosphate decarboxylase activity
NtRootA2_21970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NtRootA2_21980	COG0505	Belongs to the CarA family
NtRootA2_22000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NtRootA2_22010	COG0540	Belongs to the ATCase OTCase family
NtRootA2_22020	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NtRootA2_22040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NtRootA2_22050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NtRootA2_22070	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NtRootA2_22080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NtRootA2_22090	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NtRootA2_22100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NtRootA2_22130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NtRootA2_22160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NtRootA2_22200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NtRootA2_22210	COG0124	histidyl-tRNA synthetase
NtRootA2_22230	COG1196	nuclear chromosome segregation
NtRootA2_22250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NtRootA2_22260	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NtRootA2_22270	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NtRootA2_22290	COG2255	four-way junction helicase activity
NtRootA2_22300	COG0632	four-way junction helicase activity
NtRootA2_22310	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NtRootA2_22320	COG0217	transcriptional regulatory protein
NtRootA2_22330	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NtRootA2_22370	COG0339	signal peptide processing
NtRootA2_22380	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NtRootA2_22390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NtRootA2_22410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NtRootA2_22420	COG0587	DNA-directed DNA polymerase activity
NtRootA2_22470	COG2135	peptidase activity
NtRootA2_22500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NtRootA2_22560	COG0644	oxidoreductase
NtRootA2_22590	COG4804	nuclease activity
NtRootA2_22610	COG3842	ATPase activity
NtRootA2_22640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NtRootA2_22650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NtRootA2_22660	COG1780	Probably involved in ribonucleotide reductase function
NtRootA2_22680	COG0583	DNA-binding transcription factor activity
NtRootA2_22750	COG0714	Associated with various cellular activities
NtRootA2_22780	COG1175	transmembrane transport
NtRootA2_22810	COG2813	Specifically methylates the guanine in position
NtRootA2_22840	COG0799	negative regulation of ribosome biogenesis
NtRootA2_22860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NtRootA2_22880	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NtRootA2_22890	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NtRootA2_22900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NtRootA2_22910	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NtRootA2_22920	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NtRootA2_22930	COG0351	phosphomethylpyrimidine kinase
NtRootA2_22930	COG0352	thiamine-phosphate diphosphorylase activity
NtRootA2_22930	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NtRootA2_22940	COG1530	ribonuclease E activity
NtRootA2_22960	COG0105	UTP biosynthetic process
NtRootA2_22980	COG0285	dihydrofolate synthase activity
NtRootA2_22990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NtRootA2_23020	COG0525	valine-tRNA ligase activity
NtRootA2_23030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NtRootA2_23040	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NtRootA2_23050	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NtRootA2_23060	COG0740	serine-type endopeptidase activity
NtRootA2_23070	COG0740	serine-type endopeptidase activity
NtRootA2_23080	COG0544	peptidyl-prolyl cis-trans isomerase activity
NtRootA2_23150	COG0668	transmembrane transport
NtRootA2_23180	COG1946	Acyl-CoA thioesterase
NtRootA2_23230	COG0629	single-stranded DNA binding
NtRootA2_23270	COG0242	peptide deformylase activity
NtRootA2_23320	COG3022	response to hydroperoxide
NtRootA2_23340	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NtRootA2_23350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NtRootA2_23370	COG1045	serine acetyltransferase
NtRootA2_23380	COG0300	oxidoreductase activity
NtRootA2_23390	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NtRootA2_23410	COG1063	alcohol dehydrogenase
NtRootA2_23420	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_23440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootA2_23460	COG0477	Major facilitator Superfamily
NtRootA2_23530	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NtRootA2_23560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NtRootA2_23570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NtRootA2_23600	COG4974	Belongs to the 'phage' integrase family
NtRootA2_23630	COG0792	nuclease activity
NtRootA2_23650	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NtRootA2_23670	COG0681	Belongs to the peptidase S26 family
NtRootA2_23680	COG0335	large ribosomal subunit rRNA binding
NtRootA2_23690	COG0336	Belongs to the RNA methyltransferase TrmD family
NtRootA2_23700	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NtRootA2_23710	COG1837	Belongs to the UPF0109 family
NtRootA2_23720	COG0228	four-way junction DNA binding
NtRootA2_23740	COG2514	catechol 2,3-dioxygenase activity
NtRootA2_23790	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NtRootA2_23820	COG2814	Major facilitator Superfamily
NtRootA2_23890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NtRootA2_23900	COG0571	ribonuclease III activity
NtRootA2_23910	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NtRootA2_23930	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NtRootA2_23960	COG0742	ribosomal rna small subunit methyltransferase
NtRootA2_23980	COG1461	Dihydroxyacetone kinase
NtRootA2_24010	COG1181	Belongs to the D-alanine--D-alanine ligase family
NtRootA2_24020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NtRootA2_24040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NtRootA2_24050	COG0066	3-isopropylmalate dehydratase activity
NtRootA2_24060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NtRootA2_24070	COG1414	Transcriptional regulator
NtRootA2_24120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NtRootA2_24130	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA2_24140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NtRootA2_24160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NtRootA2_24170	COG0473	3-isopropylmalate dehydrogenase activity
NtRootA2_24180	COG4585	Histidine kinase
NtRootA2_24190	COG2197	response regulator
NtRootA2_24200	COG0577	efflux transmembrane transporter activity
NtRootA2_24200	COG1136	(ABC) transporter
NtRootA2_24230	COG1136	(ABC) transporter
NtRootA2_24230	COG0577	efflux transmembrane transporter activity
NtRootA2_24250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootA2_24260	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NtRootA2_24270	COG0440	acetolactate synthase activity
NtRootA2_24290	COG0129	dihydroxy-acid dehydratase activity
NtRootA2_24310	COG0088	Forms part of the polypeptide exit tunnel
NtRootA2_24350	COG0747	negative chemotaxis
NtRootA2_24360	COG0579	oxidoreductase
NtRootA2_24370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NtRootA2_24380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA2_24400	COG1305	Transglutaminase-like
NtRootA2_24440	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA2_24460	COG1104	cysteine desulfurase activity
NtRootA2_24480	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NtRootA2_24490	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NtRootA2_24510	COG1522	sequence-specific DNA binding
NtRootA2_24520	COG1113	amino acid transport
NtRootA2_24540	COG0022	dehydrogenase e1 component
NtRootA2_24550	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA2_24590	COG0477	Major facilitator Superfamily
NtRootA2_24600	COG1414	Transcriptional regulator
NtRootA2_24660	COG1116	anion transmembrane transporter activity
NtRootA2_24670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NtRootA2_24700	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NtRootA2_24730	COG0419	ATPase involved in DNA repair
NtRootA2_24740	COG0420	3'-5' exonuclease activity
NtRootA2_24770	COG2149	membrane
NtRootA2_24820	COG1131	(ABC) transporter
NtRootA2_24850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NtRootA2_24860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NtRootA2_24870	COG1234	tRNA 3'-trailer cleavage
NtRootA2_24880	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NtRootA2_24900	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NtRootA2_24920	COG1335	isochorismatase
NtRootA2_24950	COG0363	glucosamine-6-phosphate deaminase activity
NtRootA2_24980	COG1902	pentaerythritol trinitrate reductase activity
NtRootA2_25040	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
NtRootA2_25050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NtRootA2_25070	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NtRootA2_25080	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NtRootA2_25100	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NtRootA2_25110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NtRootA2_25120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NtRootA2_25130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NtRootA2_25140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NtRootA2_25150	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NtRootA2_25160	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NtRootA2_25170	COG0356	it plays a direct role in the translocation of protons across the membrane
NtRootA2_25210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NtRootA2_25240	COG0009	L-threonylcarbamoyladenylate synthase
NtRootA2_25250	COG2890	protein-(glutamine-N5) methyltransferase activity
NtRootA2_25260	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NtRootA2_25280	COG0083	homoserine kinase activity
NtRootA2_25290	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NtRootA2_25300	COG0460	homoserine dehydrogenase
NtRootA2_25310	COG0019	diaminopimelate decarboxylase activity
NtRootA2_25320	COG0018	arginyl-trna synthetase
NtRootA2_25360	COG1017	nitric oxide dioxygenase activity
NtRootA2_25360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NtRootA2_25420	COG1643	Atp-dependent helicase
NtRootA2_25430	COG0537	adenosine 5'-monophosphoramidase activity
NtRootA2_25440	COG1064	alcohol dehydrogenase
NtRootA2_25480	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NtRootA2_25510	COG1121	(ABC) transporter
NtRootA2_25520	COG0803	Belongs to the bacterial solute-binding protein 9 family
NtRootA2_25540	COG1253	flavin adenine dinucleotide binding
NtRootA2_25550	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA2_25550	COG0567	Dehydrogenase, E1 component
NtRootA2_25620	COG1595	DNA-templated transcription, initiation
NtRootA2_25640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NtRootA2_25660	COG0483	inositol monophosphate 1-phosphatase activity
NtRootA2_25670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NtRootA2_25730	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NtRootA2_25750	COG2177	Part of the ABC transporter FtsEX involved in
NtRootA2_25760	COG2884	Cell division ATP-binding protein ftsE
NtRootA2_25770	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NtRootA2_25890	COG1216	Glycosyl transferase, family 2
NtRootA2_25940	COG1216	Glycosyl transferase, family 2
NtRootA2_25980	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NtRootA2_26010	COG0433	COG0433 Predicted ATPase
NtRootA2_26010	COG1674	ftsk spoiiie
NtRootA2_26050	COG2902	Dehydrogenase
NtRootA2_26120	COG0653	protein targeting
NtRootA2_26130	COG3214	Protein conserved in bacteria
NtRootA2_26140	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NtRootA2_26170	COG5401	PFAM Sporulation and spore germination
NtRootA2_26180	COG5002	protein histidine kinase activity
NtRootA2_26230	COG0714	Associated with various cellular activities
NtRootA2_26300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootA2_26310	COG0601	transmembrane transport
NtRootA2_26350	COG0482	sulfurtransferase activity
NtRootA2_26360	COG1053	succinate dehydrogenase
NtRootA2_26390	COG0446	pyridine nucleotide-disulphide oxidoreductase
NtRootA2_26390	COG1902	pentaerythritol trinitrate reductase activity
NtRootA2_26400	COG0673	inositol 2-dehydrogenase activity
NtRootA2_26420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NtRootA2_26430	COG0477	Major facilitator Superfamily
NtRootA2_26440	COG0583	DNA-binding transcription factor activity
NtRootA2_26480	COG0484	heat shock protein binding
NtRootA2_26490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NtRootA2_26500	COG1595	DNA-templated transcription, initiation
NtRootA2_26530	COG3265	gluconokinase activity
NtRootA2_26540	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NtRootA2_26550	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NtRootA2_26560	COG2086	electron transfer activity
NtRootA2_26570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NtRootA2_26600	COG1842	Phage shock protein A
NtRootA2_26620	COG1615	UPF0182 protein
NtRootA2_26630	COG3480	Lon protease (S16) C-terminal proteolytic domain
NtRootA2_26670	COG2816	NAD+ diphosphatase activity
NtRootA2_26730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA2_26740	COG0765	amino acid transport
NtRootA2_26750	COG1126	abc transporter atp-binding protein
NtRootA2_26780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NtRootA2_26800	COG0113	porphobilinogen synthase activity
NtRootA2_26820	COG0181	hydroxymethylbilane synthase activity
NtRootA2_26830	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NtRootA2_26840	COG3253	May function as heme-dependent peroxidase
NtRootA2_26850	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NtRootA2_26860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NtRootA2_26870	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NtRootA2_26900	COG1309	transcriptional regulator
NtRootA2_26960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NtRootA2_26960	COG2022	thiamine diphosphate biosynthetic process
NtRootA2_26970	COG0352	thiamine-phosphate diphosphorylase activity
NtRootA2_26990	COG2267	carboxylic ester hydrolase activity
NtRootA2_27010	COG0513	Belongs to the DEAD box helicase family
NtRootA2_27030	COG2095	MarC family integral membrane protein
NtRootA2_27050	COG0006	proline dipeptidase activity
NtRootA2_27070	COG2239	Acts as a magnesium transporter
NtRootA2_27100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NtRootA2_27120	COG1595	DNA-templated transcription, initiation
NtRootA2_27180	COG1126	abc transporter atp-binding protein
NtRootA2_27190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA2_27200	COG0765	amino acid transport
NtRootA2_27210	COG0765	amino acid transport
NtRootA2_27220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NtRootA2_27230	COG2171	N-acyltransferase activity
NtRootA2_27260	COG3226	Transcriptional regulator
NtRootA2_27270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NtRootA2_27330	COG1217	gtp-binding protein TYPA
NtRootA2_27360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootA2_27380	COG4166	transmembrane transport
NtRootA2_27400	COG0012	GTP binding
NtRootA2_27410	COG1322	Protein conserved in bacteria
NtRootA2_27420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NtRootA2_27440	COG1570	exodeoxyribonuclease VII activity
NtRootA2_27450	COG1722	exodeoxyribonuclease VII activity
NtRootA2_27460	COG2326	polyphosphate kinase activity
NtRootA2_27500	COG1174	glycine betaine transport
NtRootA2_27520	COG1162	GTPase activity
NtRootA2_27570	COG2971	BadF BadG BcrA BcrD
NtRootA2_27590	COG0583	DNA-binding transcription factor activity
NtRootA2_27600	COG2814	Major facilitator Superfamily
NtRootA2_27610	COG3548	integral membrane protein
NtRootA2_27660	COG0598	Magnesium transport protein CorA
NtRootA2_27680	COG1528	Iron-storage protein
NtRootA2_27690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NtRootA2_27700	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NtRootA2_27720	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NtRootA2_27730	COG1695	Transcriptional regulator
NtRootA2_27930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NtRootA2_28050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NtRootA2_28060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NtRootA2_28070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NtRootA2_28110	COG0519	Catalyzes the synthesis of GMP from XMP
NtRootA2_28110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NtRootA2_28150	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NtRootA2_28160	COG0516	GMP reductase activity
NtRootA2_28200	COG1132	(ABC) transporter
NtRootA2_28240	COG0459	protein refolding
NtRootA2_28250	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NtRootA2_28280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NtRootA2_28290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NtRootA2_28310	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NtRootA2_28320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NtRootA2_28350	COG0802	atpase or kinase
NtRootA2_28360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NtRootA2_28400	COG0438	transferase activity, transferring glycosyl groups
NtRootA2_28410	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NtRootA2_28430	COG0667	Aldo Keto reductase
NtRootA2_28480	COG0736	holo-[acyl-carrier-protein] synthase activity
NtRootA2_28500	COG1072	(Pantothenic acid kinase))
NtRootA2_28520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NtRootA2_28530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NtRootA2_28540	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NtRootA2_28580	COG2894	cell division
NtRootA2_28640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NtRootA2_28660	COG0101	tRNA pseudouridine synthase activity
NtRootA2_28670	COG0203	ribosomal protein L17
NtRootA2_28680	COG0202	RNA polymerase activity
NtRootA2_28690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NtRootA2_28700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NtRootA2_28710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NtRootA2_28720	COG3191	aminopeptidase activity
NtRootA2_28780	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootA2_28790	COG2124	cytochrome p450
NtRootA2_28800	COG1216	Glycosyl transferase, family 2
NtRootA2_28810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NtRootA2_28820	COG0563	adenylate kinase activity
NtRootA2_28840	COG0200	Binds to the 23S rRNA
NtRootA2_28850	COG1841	ribosomal large subunit assembly
NtRootA2_28860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NtRootA2_28880	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NtRootA2_28890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NtRootA2_28900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NtRootA2_28910	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NtRootA2_28920	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NtRootA2_28930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NtRootA2_28940	COG0255	Belongs to the universal ribosomal protein uL29 family
NtRootA2_28950	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NtRootA2_28960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NtRootA2_28970	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NtRootA2_28980	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NtRootA2_28990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NtRootA2_29000	COG0089	rRNA binding
NtRootA2_29010	COG0088	Forms part of the polypeptide exit tunnel
NtRootA2_29020	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NtRootA2_29030	COG0051	transcription antitermination factor activity, RNA binding
NtRootA2_29070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NtRootA2_29080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NtRootA2_29090	COG0049	tRNA binding
NtRootA2_29100	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NtRootA2_29110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NtRootA2_29120	COG0085	RNA polymerase activity
NtRootA2_29130	COG0183	Belongs to the thiolase family
NtRootA2_29140	COG0442	prolyl-tRNA aminoacylation
NtRootA2_29150	COG0222	ribosome binding
NtRootA2_29160	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NtRootA2_29200	COG0081	regulation of translation
NtRootA2_29210	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NtRootA2_29240	COG0436	Aminotransferase
NtRootA2_29250	COG2197	response regulator
NtRootA2_29370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NtRootA2_29390	COG3485	protocatechuate 3,4-dioxygenase
NtRootA2_29420	COG0745	RESPONSE REGULATOR receiver
NtRootA2_29430	COG0456	acetyltransferase
NtRootA2_29440	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NtRootA2_29450	COG0406	alpha-ribazole phosphatase activity
NtRootA2_29450	COG0494	nUDIX hydrolase
NtRootA2_29490	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NtRootA2_29500	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NtRootA2_29520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NtRootA2_29560	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NtRootA2_29570	COG0738	Major facilitator superfamily
NtRootA2_29590	COG2030	dehydratase
NtRootA2_29650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NtRootA2_29670	COG4989	oxidoreductase activity
NtRootA2_29680	COG0366	Alpha amylase catalytic
NtRootA2_29690	COG0395	ABC-type sugar transport system, permease component
NtRootA2_29700	COG1175	transmembrane transport
NtRootA2_29730	COG1940	carbohydrate kinase activity
NtRootA2_29760	COG1376	ErfK ybiS ycfS ynhG family protein
NtRootA2_29820	COG0754	glutathionylspermidine amidase activity
NtRootA2_29840	COG5650	phosphatidylinositol metabolic process
NtRootA2_29880	COG1175	transmembrane transport
NtRootA2_29890	COG0395	ABC-type sugar transport system, permease component
NtRootA2_29940	COG5650	phosphatidylinositol metabolic process
NtRootA2_30000	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootA2_30020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NtRootA2_30030	COG1309	transcriptional regulator
NtRootA2_30040	COG1131	(ABC) transporter
NtRootA2_30080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NtRootA2_30100	COG1666	GTP binding
NtRootA2_30110	COG0672	)-iron permease
NtRootA2_30130	COG2837	iron assimilation
NtRootA2_30160	COG0501	Belongs to the peptidase M48B family
NtRootA2_30220	COG0531	amino acid
NtRootA2_30320	COG0395	ABC-type sugar transport system, permease component
NtRootA2_30330	COG4209	transmembrane transport
NtRootA2_30350	COG1609	Transcriptional regulator
NtRootA2_30390	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA2_30400	COG3835	regulator
NtRootA2_30410	COG2807	transmembrane transport
NtRootA2_30420	COG2186	Transcriptional regulator
NtRootA2_30430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NtRootA2_30430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NtRootA2_30450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NtRootA2_30450	COG1648	precorrin-2 dehydrogenase activity
NtRootA2_30460	COG2066	Belongs to the glutaminase family
NtRootA2_30470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA2_30520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NtRootA2_30530	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NtRootA2_30550	COG2040	homocysteine
NtRootA2_30560	COG2895	sulfate adenylyltransferase (ATP) activity
NtRootA2_30580	COG0175	sulfate reduction
NtRootA2_30610	COG2860	membrane
NtRootA2_30640	COG0142	geranyltranstransferase activity
NtRootA2_30660	COG2226	methyltransferase
NtRootA2_30670	COG1169	isochorismate synthase
NtRootA2_30680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA2_30690	COG0765	amino acid transport
NtRootA2_30720	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NtRootA2_30740	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootA2_30800	COG0395	ABC-type sugar transport system, permease component
NtRootA2_30810	COG1175	transmembrane transport
NtRootA2_30900	COG1404	Belongs to the peptidase S8 family
NtRootA2_30960	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA2_30970	COG0022	dehydrogenase e1 component
NtRootA2_31010	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NtRootA2_31030	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NtRootA2_31040	COG1088	dTDP-glucose 4,6-dehydratase activity
NtRootA2_31060	COG0489	protein tyrosine kinase activity
NtRootA2_31140	COG0438	transferase activity, transferring glycosyl groups
NtRootA2_31140	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NtRootA2_31160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NtRootA2_31240	COG2267	carboxylic ester hydrolase activity
NtRootA2_31260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NtRootA2_31270	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NtRootA2_31280	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NtRootA2_31290	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NtRootA2_31420	COG1846	Transcriptional regulator
NtRootA2_31430	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NtRootA2_31470	COG1063	alcohol dehydrogenase
NtRootA2_31500	COG0667	Aldo Keto reductase
NtRootA2_31560	COG1024	Enoyl-CoA hydratase
NtRootA2_31570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NtRootA2_31580	COG2151	metal-sulfur cluster biosynthetic enzyme
NtRootA2_31590	COG3396	Phenylacetate-CoA oxygenase
NtRootA2_31600	COG3460	Phenylacetate-CoA oxygenase
NtRootA2_31610	COG3396	Phenylacetate-CoA oxygenase
NtRootA2_31620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NtRootA2_31630	COG1388	LysM domain
NtRootA2_31630	COG3942	CHAP domain
NtRootA2_31650	COG3706	GGDEF domain
NtRootA2_31680	COG0438	transferase activity, transferring glycosyl groups
NtRootA2_31700	COG0438	transferase activity, transferring glycosyl groups
NtRootA2_31730	COG2226	methyltransferase
NtRootA2_31750	COG5002	protein histidine kinase activity
NtRootA2_31800	COG2050	protein possibly involved in aromatic compounds catabolism
NtRootA2_31830	COG2030	dehydratase
NtRootA2_31830	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA2_31860	COG1250	3-hydroxyacyl-CoA dehydrogenase
NtRootA2_31870	COG1024	Enoyl-CoA hydratase
NtRootA2_31930	COG1266	CAAX protease self-immunity
NtRootA2_31950	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NtRootA2_32050	COG0443	Heat shock 70 kDa protein
NtRootA2_32060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NtRootA2_32080	COG0785	Cytochrome C biogenesis protein
NtRootA2_32100	COG0406	alpha-ribazole phosphatase activity
NtRootA2_32160	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NtRootA2_32210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NtRootA2_32220	COG3458	cephalosporin-C deacetylase activity
NtRootA2_32240	COG2814	Major facilitator Superfamily
NtRootA2_32260	COG0395	ABC-type sugar transport system, permease component
NtRootA2_32270	COG1175	transmembrane transport
NtRootA2_32310	COG0395	ABC-type sugar transport system, permease component
NtRootA2_32320	COG1175	transmembrane transport
NtRootA2_32340	COG0673	inositol 2-dehydrogenase activity
NtRootA2_32370	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootA2_32380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NtRootA2_32400	COG0673	inositol 2-dehydrogenase activity
NtRootA2_32410	COG1609	Transcriptional regulator
NtRootA2_32440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NtRootA2_32450	COG0640	Transcriptional regulator
NtRootA2_32470	COG0123	including yeast histone deacetylase and acetoin utilization protein
NtRootA2_32480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NtRootA2_32490	COG0569	domain protein
NtRootA2_32500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NtRootA2_32510	COG1082	Xylose isomerase domain protein TIM barrel
NtRootA2_32520	COG0248	Ppx GppA phosphatase
NtRootA2_32540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NtRootA2_32540	COG1754	DNA topoisomerase type I activity
NtRootA2_32590	COG1054	Belongs to the UPF0176 family
NtRootA2_32610	COG1111	helicase
NtRootA2_32610	COG1205	dead DEAH box helicase
NtRootA2_32750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NtRootA2_32760	COG1349	DNA-binding transcription factor activity
NtRootA2_32790	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA2_32800	COG1609	Transcriptional regulator
NtRootA2_32820	COG1175	transmembrane transport
NtRootA2_32830	COG0395	ABC-type sugar transport system, permease component
NtRootA2_32920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NtRootA2_32930	COG1408	metallophosphoesterase
NtRootA2_32940	COG1132	(ABC) transporter
NtRootA2_32950	COG1132	(ABC) transporter
NtRootA2_32990	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NtRootA2_33000	COG0151	Belongs to the GarS family
NtRootA2_33040	COG1301	dicarboxylic acid transport
NtRootA2_33060	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_33080	COG1953	Uracil, thiamine, allantoin
NtRootA2_33090	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NtRootA2_33120	COG0454	-acetyltransferase
NtRootA2_33130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NtRootA2_33150	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NtRootA2_33150	COG3608	succinylglutamate desuccinylase aspartoacylase
NtRootA2_33160	COG2252	PERMEase
NtRootA2_33170	COG0590	tRNA wobble adenosine to inosine editing
NtRootA2_33240	COG2233	PERMEase
NtRootA2_33250	COG1414	Transcriptional regulator
NtRootA2_33270	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NtRootA2_33290	COG3257	ureidoglycine aminohydrolase activity
NtRootA2_33320	COG0395	ABC-type sugar transport system, permease component
NtRootA2_33340	COG1653	transport
NtRootA2_33360	COG3119	arylsulfatase activity
NtRootA2_33370	COG1609	Transcriptional regulator
NtRootA2_33380	COG5492	domain, Protein
NtRootA2_33390	COG3654	unkown
NtRootA2_33410	COG2318	DinB family
NtRootA2_33470	COG2271	Major facilitator Superfamily
NtRootA2_33500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NtRootA2_33500	COG4499	WXG100 protein secretion system (Wss), protein YukC
NtRootA2_33520	COG2814	Major facilitator Superfamily
NtRootA2_33550	COG0659	secondary active sulfate transmembrane transporter activity
NtRootA2_33630	COG0563	adenylate kinase activity
NtRootA2_33650	COG0477	Major facilitator Superfamily
NtRootA2_33670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NtRootA2_33690	COG3401	FG-GAP repeat protein
NtRootA2_33700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA2_33740	COG2011	ABC-type metal ion transport system permease component
NtRootA2_33750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NtRootA2_33760	COG1464	Belongs to the NlpA lipoprotein family
NtRootA2_33770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA2_33860	COG2267	carboxylic ester hydrolase activity
NtRootA2_33920	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NtRootA2_33930	COG1733	regulation of RNA biosynthetic process
NtRootA2_33940	COG3025	triphosphatase activity
NtRootA2_33940	COG5607	PFAM CHAD domain containing protein
NtRootA2_34020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NtRootA2_34100	COG0405	Gamma-glutamyltransferase
NtRootA2_34220	COG0673	inositol 2-dehydrogenase activity
NtRootA2_34240	COG0673	inositol 2-dehydrogenase activity
NtRootA2_34270	COG1653	transport
NtRootA2_34280	COG1609	Transcriptional regulator
NtRootA2_34350	COG3622	Belongs to the hyi family
NtRootA2_34360	COG2084	Dehydrogenase
NtRootA2_34370	COG3960	tartronate-semialdehyde synthase activity
NtRootA2_34380	COG1929	Belongs to the glycerate kinase type-1 family
NtRootA2_34390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NtRootA2_34400	COG0745	RESPONSE REGULATOR receiver
NtRootA2_34430	COG0745	RESPONSE REGULATOR receiver
NtRootA2_34440	COG1215	transferase activity, transferring glycosyl groups
NtRootA2_34450	COG1366	Belongs to the anti-sigma-factor antagonist family
NtRootA2_34470	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NtRootA2_34510	COG2814	Major facilitator Superfamily
NtRootA2_34530	COG0671	phosphoesterase, PA-phosphatase related
NtRootA2_34560	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA2_34590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NtRootA2_34630	COG0542	response to heat
NtRootA2_34680	COG3585	molybdate ion transport
NtRootA2_34690	COG4585	Histidine kinase
NtRootA2_34700	COG2197	response regulator
NtRootA2_34760	COG3304	Inner membrane component domain
NtRootA2_34770	COG0135	phosphoribosylanthranilate isomerase activity
NtRootA2_34810	COG0667	Aldo Keto reductase
NtRootA2_34840	COG2814	Major facilitator Superfamily
NtRootA2_34860	COG2813	Specifically methylates the guanine in position
NtRootA2_34880	COG1473	amidohydrolase
NtRootA2_34890	COG0477	Major facilitator Superfamily
NtRootA2_34900	COG2807	transmembrane transport
NtRootA2_34930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NtRootA2_35040	COG2188	Transcriptional regulator
NtRootA2_35110	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA2_35140	COG0596	Alpha beta hydrolase
NtRootA2_35140	COG2945	thiolester hydrolase activity
NtRootA2_35150	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_35220	COG1846	Transcriptional regulator
NtRootA2_35230	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
NtRootA2_35240	COG0789	Transcriptional regulator
NtRootA2_35250	COG0484	heat shock protein binding
NtRootA2_35260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NtRootA2_35270	COG0443	Heat shock 70 kDa protein
NtRootA2_35280	COG3739	integral membrane protein
NtRootA2_35330	COG1917	Cupin 2, conserved barrel domain protein
NtRootA2_35330	COG4977	sequence-specific DNA binding
NtRootA2_35360	COG3540	Alkaline phosphatase
NtRootA2_35370	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
NtRootA2_35440	COG0531	amino acid
NtRootA2_35470	COG3226	Transcriptional regulator
NtRootA2_35480	COG1280	lysine exporter protein (LysE YggA)
NtRootA2_35530	COG0492	ferredoxin-NADP+ reductase activity
NtRootA2_35540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NtRootA2_35550	COG0798	PFAM Bile acid sodium symporter
NtRootA2_35560	COG0640	Transcriptional regulator
NtRootA2_35580	COG2409	Drug exporters of the RND superfamily
NtRootA2_35610	COG3795	YCII-related domain
NtRootA2_35630	COG4941	Belongs to the sigma-70 factor family
NtRootA2_35670	COG1280	lysine exporter protein (LysE YggA)
NtRootA2_35690	COG1609	Transcriptional regulator
NtRootA2_35700	COG1957	nucleoside hydrolase
NtRootA2_35710	COG0477	Major facilitator Superfamily
NtRootA2_35720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NtRootA2_35750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NtRootA2_35770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NtRootA2_35790	COG0833	amino acid
NtRootA2_35800	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NtRootA2_35820	COG2986	histidine ammonia-lyase
NtRootA2_35880	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NtRootA2_35900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NtRootA2_35910	COG1132	(ABC) transporter
NtRootA2_35910	COG2375	cellular response to nickel ion
NtRootA2_35950	COG1122	ATPase activity
NtRootA2_35960	COG4721	ABC-type cobalt transport system, permease component
NtRootA2_35990	COG1320	monovalent cation:proton antiporter activity
NtRootA2_36000	COG2212	antiporter activity
NtRootA2_36020	COG0651	ATP synthesis coupled electron transport
NtRootA2_36030	COG1006	Multisubunit Na H antiporter MnhC subunit
NtRootA2_36040	COG2111	Na H antiporter
NtRootA2_36040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NtRootA2_36070	COG0475	glutathione-regulated potassium exporter activity
NtRootA2_36090	COG0717	Belongs to the dCTP deaminase family
NtRootA2_36120	COG1876	peptidase activity
NtRootA2_36130	COG0686	Belongs to the AlaDH PNT family
NtRootA2_36150	COG0583	DNA-binding transcription factor activity
NtRootA2_36170	COG0640	Transcriptional regulator
NtRootA2_36210	COG0657	acetylesterase activity
NtRootA2_36210	COG2755	lipolytic protein G-D-S-L family
NtRootA2_36220	COG1609	Transcriptional regulator
NtRootA2_36230	COG0673	inositol 2-dehydrogenase activity
NtRootA2_36290	COG2115	Belongs to the xylose isomerase family
NtRootA2_36300	COG1070	Carbohydrate kinase
NtRootA2_36310	COG1609	Transcriptional regulator
NtRootA2_36340	COG2160	L-arabinose isomerase activity
NtRootA2_36350	COG2017	converts alpha-aldose to the beta-anomer
NtRootA2_36370	COG2211	Major facilitator Superfamily
NtRootA2_36380	COG1846	Transcriptional regulator
NtRootA2_36380	COG1940	carbohydrate kinase activity
NtRootA2_36400	COG0765	amino acid transport
NtRootA2_36410	COG0765	amino acid transport
NtRootA2_36440	COG0251	oxidation-reduction process
NtRootA2_36470	COG0583	DNA-binding transcription factor activity
NtRootA2_36500	COG1609	Transcriptional regulator
NtRootA2_36510	COG3254	rhamnose metabolic process
NtRootA2_36530	COG3347	Dehydrogenase
NtRootA2_36530	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_36540	COG1070	Carbohydrate kinase
NtRootA2_36550	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NtRootA2_36570	COG3387	PFAM Glycoside hydrolase 15-related
NtRootA2_36580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA2_36590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA2_36600	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NtRootA2_36640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA2_36650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA2_36670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA2_36690	COG1126	abc transporter atp-binding protein
NtRootA2_36700	COG0765	amino acid transport
NtRootA2_36730	COG0433	COG0433 Predicted ATPase
NtRootA2_36760	COG3336	cytochrome c oxidase
NtRootA2_36770	COG0776	regulation of translation
NtRootA2_36820	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NtRootA2_36830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NtRootA2_36840	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NtRootA2_36850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NtRootA2_36850	COG1017	nitric oxide dioxygenase activity
NtRootA2_36940	COG1120	ATPase activity
NtRootA2_36950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootA2_36960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootA2_37040	COG3012	SEC-C Motif Domain Protein
NtRootA2_37070	COG0667	Aldo Keto reductase
NtRootA2_37150	COG2186	Transcriptional regulator
NtRootA2_37170	COG1027	Aspartate ammonia-lyase
NtRootA2_37220	COG3254	rhamnose metabolic process
NtRootA2_37240	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootA2_37260	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_37280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NtRootA2_37310	COG4221	oxidoreductase activity
NtRootA2_37330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NtRootA2_37340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NtRootA2_37380	COG1522	sequence-specific DNA binding
NtRootA2_37390	COG1280	lysine exporter protein (LysE YggA)
NtRootA2_37410	COG0640	Transcriptional regulator
NtRootA2_37450	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA2_37470	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA2_37480	COG1414	Transcriptional regulator
NtRootA2_37500	COG0477	Major facilitator Superfamily
NtRootA2_37520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NtRootA2_37570	COG1760	l-serine dehydratase
NtRootA2_37620	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA2_37640	COG0281	malic enzyme
NtRootA2_37650	COG1309	transcriptional regulator
NtRootA2_37690	COG2211	Major facilitator Superfamily
NtRootA2_37700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NtRootA2_37710	COG0477	Major facilitator Superfamily
NtRootA2_37720	COG0477	Major facilitator Superfamily
NtRootA2_37730	COG2814	Major facilitator Superfamily
NtRootA2_37800	COG1113	amino acid transport
NtRootA2_37810	COG0246	Mannitol dehydrogenase
NtRootA2_37820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NtRootA2_37820	COG2213	PTS system mannitol-specific
NtRootA2_37840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NtRootA2_37880	COG0596	Alpha beta hydrolase
NtRootA2_37900	COG1793	dna ligase
NtRootA2_37950	COG0686	Belongs to the AlaDH PNT family
NtRootA2_37990	COG0673	inositol 2-dehydrogenase activity
NtRootA2_38040	COG1309	transcriptional regulator
NtRootA2_38050	COG0431	NADPH-dependent FMN reductase
NtRootA2_38100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NtRootA2_38140	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA2_38150	COG0022	dehydrogenase e1 component
NtRootA2_38170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NtRootA2_38180	COG1950	PFAM Membrane protein of
NtRootA2_38210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NtRootA2_38240	COG1607	acyl-coa hydrolase
NtRootA2_38250	COG4221	oxidoreductase activity
NtRootA2_38260	COG0477	Major facilitator Superfamily
NtRootA2_38270	COG1984	allophanate hydrolase subunit 2
NtRootA2_38280	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NtRootA2_38290	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NtRootA2_38300	COG0583	DNA-binding transcription factor activity
NtRootA2_38320	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NtRootA2_38330	COG0436	Aminotransferase
NtRootA2_38380	COG3971	2-oxopent-4-enoate hydratase activity
NtRootA2_38410	COG1802	Transcriptional regulator
NtRootA2_38420	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA2_38480	COG2207	Transcriptional regulator
NtRootA2_38480	COG3708	Transcriptional regulator
NtRootA2_38490	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_38650	COG2205	protein histidine kinase activity
NtRootA2_38660	COG0515	serine threonine protein kinase
NtRootA2_38660	COG2815	serine threonine protein kinase
NtRootA2_38700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NtRootA2_38710	COG3387	PFAM Glycoside hydrolase 15-related
NtRootA2_38730	COG0076	glutamate decarboxylase activity
NtRootA2_38750	COG1011	Hydrolase
NtRootA2_38790	COG1414	Transcriptional regulator
NtRootA2_38800	COG2814	Major facilitator Superfamily
NtRootA2_38890	COG1846	Transcriptional regulator
NtRootA2_38950	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NtRootA2_38960	COG1760	l-serine dehydratase
NtRootA2_38970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NtRootA2_38980	COG0509	glycine decarboxylation via glycine cleavage system
NtRootA2_38990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NtRootA2_39000	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NtRootA2_39000	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NtRootA2_39020	COG2271	Major facilitator Superfamily
NtRootA2_39040	COG1970	mechanosensitive ion channel activity
NtRootA2_39350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NtRootA2_39370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NtRootA2_39420	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA2_39430	COG2814	Major facilitator Superfamily
NtRootA2_39450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NtRootA2_39480	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA2_39490	COG0251	oxidation-reduction process
NtRootA2_39510	COG1414	Transcriptional regulator
NtRootA2_39520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NtRootA2_39540	COG0183	Belongs to the thiolase family
NtRootA2_39550	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NtRootA2_39560	COG2267	carboxylic ester hydrolase activity
NtRootA2_39590	COG3485	protocatechuate 3,4-dioxygenase
NtRootA2_39600	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NtRootA2_39600	COG1082	Xylose isomerase domain protein TIM barrel
NtRootA2_39610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NtRootA2_39620	COG1414	Transcriptional regulator
NtRootA2_39660	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NtRootA2_39680	COG3706	GGDEF domain
NtRootA2_39750	COG0583	DNA-binding transcription factor activity
NtRootA2_39820	COG2610	gluconate transmembrane transporter activity
NtRootA2_39830	COG0800	Aldolase
NtRootA2_39840	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
NtRootA2_39870	COG1414	Transcriptional regulator
NtRootA2_39960	COG2326	polyphosphate kinase activity
NtRootA2_39980	COG1737	Transcriptional regulator
NtRootA2_39990	COG3876	Protein conserved in bacteria
NtRootA2_40000	COG1472	Belongs to the glycosyl hydrolase 3 family
NtRootA2_40040	COG1937	Protein conserved in bacteria
NtRootA2_40050	COG2217	Heavy metal translocating P-type atpase
NtRootA2_40160	COG0534	Mate efflux family protein
NtRootA2_40180	COG2259	Doxx family
NtRootA2_40210	COG3848	Pyruvate phosphate dikinase
NtRootA2_40210	COG0574	Belongs to the PEP-utilizing enzyme family
NtRootA2_40230	COG1607	acyl-coa hydrolase
NtRootA2_40260	COG3958	Transketolase
NtRootA2_40270	COG3959	Transketolase, thiamine diphosphate binding domain
NtRootA2_40300	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA2_40310	COG2376	Dihydroxyacetone kinase
NtRootA2_40320	COG0698	ribose 5-phosphate isomerase
NtRootA2_40350	COG0305	Participates in initiation and elongation during chromosome replication
NtRootA2_40430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NtRootA2_40440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NtRootA2_40510	COG1131	(ABC) transporter
NtRootA2_40530	COG0384	phenazine biosynthesis protein PhzF
NtRootA2_40550	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA2_40560	COG0359	binds to the 23S rRNA
NtRootA2_40570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NtRootA2_40590	COG0360	Binds together with S18 to 16S ribosomal RNA
NtRootA2_40620	COG1113	amino acid transport
NtRootA2_40630	COG1362	aminopeptidase activity
NtRootA2_40700	COG0833	amino acid
NtRootA2_40710	COG2197	response regulator
NtRootA2_40720	COG4585	Histidine kinase
NtRootA2_40740	COG1131	(ABC) transporter
NtRootA2_40750	COG1597	lipid kinase activity
NtRootA2_40770	COG0738	Major facilitator superfamily
NtRootA2_40810	COG0768	penicillin binding
NtRootA2_40820	COG1501	Belongs to the glycosyl hydrolase 31 family
NtRootA2_40830	COG2197	response regulator
NtRootA2_40840	COG4585	Histidine kinase
NtRootA2_40860	COG1136	(ABC) transporter
NtRootA2_40870	COG1733	regulation of RNA biosynthetic process
NtRootA2_40880	COG2910	NAD(P)H-binding
NtRootA2_40920	COG0406	alpha-ribazole phosphatase activity
NtRootA2_40930	COG0617	tRNA 3'-terminal CCA addition
NtRootA2_40970	COG0492	ferredoxin-NADP+ reductase activity
NtRootA2_40980	COG3118	belongs to the thioredoxin family
NtRootA2_41030	COG1192	Involved in chromosome partitioning
NtRootA2_41040	COG0357	Ribosomal RNA small subunit methyltransferase G
NtRootA2_41060	COG0706	membrane insertase activity
NtRootA2_41070	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NtRootA2_41080	COG0594	ribonuclease P activity
NtRootA2_41090	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NtRootA2_41140	COG1192	Involved in chromosome partitioning
NtRootA2_41410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NtRootA2_41610	COG2211	Major facilitator Superfamily
NtRootA2_41740	COG3415	Transposase
NtRootA2_41740	COG2801	Transposase and inactivated derivatives
NtRootA2_41960	COG3608	succinylglutamate desuccinylase aspartoacylase
NtRootA2_41960	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NtRootA2_42060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NtRootA2_42090	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA2_42180	COG4974	Belongs to the 'phage' integrase family
NtRootA2_42240	COG1204	response to ionizing radiation
NtRootA2_42260	COG1929	Belongs to the glycerate kinase type-1 family
NtRootA2_42300	COG0673	inositol 2-dehydrogenase activity
NtRootA2_42350	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA2_42380	COG1172	Belongs to the binding-protein-dependent transport system permease family
NtRootA2_42390	COG1129	ABC transporter
NtRootA2_42450	COG4124	Belongs to the glycosyl hydrolase 26 family
NtRootA2_42520	COG2720	vancomycin resistance protein
NtRootA2_42640	COG1475	DNA binding
NtRootA2_42650	COG1609	Transcriptional regulator
NtRootA2_42660	COG2814	Major facilitator Superfamily
NtRootA2_42670	COG0657	acetylesterase activity
NtRootA2_42690	COG2267	carboxylic ester hydrolase activity
NtRootA2_42720	COG1793	dna ligase
NtRootA2_42780	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs