locus-tag	class	description
NtRootA4_00020	COG0667	Aldo Keto reductase
NtRootA4_00030	COG0656	L-ascorbic acid biosynthetic process
NtRootA4_00050	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA4_00060	COG3360	Dodecin
NtRootA4_00070	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_00100	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NtRootA4_00110	COG0028	Belongs to the TPP enzyme family
NtRootA4_00120	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NtRootA4_00130	COG1233	COG1233 Phytoene dehydrogenase and related
NtRootA4_00140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NtRootA4_00160	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_00190	COG2186	Transcriptional regulator
NtRootA4_00220	COG2084	Dehydrogenase
NtRootA4_00230	COG2610	gluconate transmembrane transporter activity
NtRootA4_00340	COG0076	glutamate decarboxylase activity
NtRootA4_00350	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NtRootA4_00440	COG1216	Glycosyl transferase, family 2
NtRootA4_00460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NtRootA4_00470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NtRootA4_00550	COG0346	lactoylglutathione lyase activity
NtRootA4_00570	COG0697	spore germination
NtRootA4_00580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NtRootA4_00590	COG2186	Transcriptional regulator
NtRootA4_00600	COG1653	transport
NtRootA4_00610	COG1175	transmembrane transport
NtRootA4_00630	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootA4_00660	COG0477	Major facilitator Superfamily
NtRootA4_00670	COG2890	protein-(glutamine-N5) methyltransferase activity
NtRootA4_00710	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NtRootA4_00720	COG0395	ABC-type sugar transport system, permease component
NtRootA4_00730	COG1175	transmembrane transport
NtRootA4_00840	COG3226	Transcriptional regulator
NtRootA4_00860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NtRootA4_00860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NtRootA4_00860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NtRootA4_00870	COG1105	Belongs to the carbohydrate kinase PfkB family
NtRootA4_00880	COG1349	DNA-binding transcription factor activity
NtRootA4_00930	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NtRootA4_00980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NtRootA4_01050	COG1846	Transcriptional regulator
NtRootA4_01110	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NtRootA4_01180	COG0129	dihydroxy-acid dehydratase activity
NtRootA4_01210	COG5006	permease, DMT superfamily
NtRootA4_01220	COG1609	Transcriptional regulator
NtRootA4_01230	COG0673	inositol 2-dehydrogenase activity
NtRootA4_01240	COG0673	inositol 2-dehydrogenase activity
NtRootA4_01260	COG0673	inositol 2-dehydrogenase activity
NtRootA4_01310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NtRootA4_01320	COG1984	allophanate hydrolase subunit 2
NtRootA4_01340	COG2733	membrane
NtRootA4_01420	COG4122	O-methyltransferase activity
NtRootA4_01430	COG0454	-acetyltransferase
NtRootA4_01430	COG0456	acetyltransferase
NtRootA4_01460	COG1132	(ABC) transporter
NtRootA4_01480	COG2207	Transcriptional regulator
NtRootA4_01520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootA4_01530	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootA4_01540	COG1120	ATPase activity
NtRootA4_01550	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA4_01580	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_01590	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA4_01650	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NtRootA4_01690	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA4_01710	COG0010	Belongs to the arginase family
NtRootA4_01720	COG2252	PERMEase
NtRootA4_01780	COG3848	Pyruvate phosphate dikinase
NtRootA4_01780	COG0574	Belongs to the PEP-utilizing enzyme family
NtRootA4_01810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NtRootA4_01990	COG0640	Transcriptional regulator
NtRootA4_02020	COG2182	Extracellular solute-binding protein
NtRootA4_02060	COG1609	Transcriptional regulator
NtRootA4_02100	COG2197	response regulator
NtRootA4_02110	COG4585	Histidine kinase
NtRootA4_02130	COG0666	response to abiotic stimulus
NtRootA4_02140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NtRootA4_02160	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NtRootA4_02230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NtRootA4_02250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NtRootA4_02260	COG0303	'Molybdopterin
NtRootA4_02270	COG1063	alcohol dehydrogenase
NtRootA4_02290	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NtRootA4_02300	COG3404	Formiminotransferase-cyclodeaminase
NtRootA4_02330	COG1802	Transcriptional regulator
NtRootA4_02340	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NtRootA4_02360	COG0583	DNA-binding transcription factor activity
NtRootA4_02390	COG2197	response regulator
NtRootA4_02440	COG0415	Belongs to the DNA photolyase family
NtRootA4_02470	COG1024	Enoyl-CoA hydratase
NtRootA4_02530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NtRootA4_02570	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA4_02610	COG0789	Transcriptional regulator
NtRootA4_02620	COG1695	Transcriptional regulator
NtRootA4_02650	COG1609	Transcriptional regulator
NtRootA4_02670	COG1175	transmembrane transport
NtRootA4_02680	COG0395	ABC-type sugar transport system, permease component
NtRootA4_02700	COG0673	inositol 2-dehydrogenase activity
NtRootA4_02720	COG1904	glucuronate isomerase
NtRootA4_02730	COG0246	Mannitol dehydrogenase
NtRootA4_02740	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootA4_02750	COG3265	gluconokinase activity
NtRootA4_02760	COG4213	ABC transporter substrate-binding protein
NtRootA4_02770	COG1129	ABC transporter
NtRootA4_02780	COG4214	carbohydrate transport
NtRootA4_02790	COG1609	Transcriptional regulator
NtRootA4_02800	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NtRootA4_02860	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA4_02880	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA4_02910	COG1120	ATPase activity
NtRootA4_02920	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootA4_02930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootA4_02940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NtRootA4_03010	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NtRootA4_03020	COG2205	protein histidine kinase activity
NtRootA4_03040	COG1309	transcriptional regulator
NtRootA4_03050	COG0477	Major facilitator Superfamily
NtRootA4_03060	COG3386	PFAM SMP-30 Gluconolaconase
NtRootA4_03090	COG0488	(ABC) transporter
NtRootA4_03130	COG0477	Major facilitator Superfamily
NtRootA4_03140	COG3263	regulation of cellular component size
NtRootA4_03150	COG5492	domain, Protein
NtRootA4_03150	COG4932	domain protein
NtRootA4_03200	COG1609	Transcriptional regulator
NtRootA4_03220	COG0765	amino acid transport
NtRootA4_03230	COG1126	abc transporter atp-binding protein
NtRootA4_03240	COG0673	inositol 2-dehydrogenase activity
NtRootA4_03340	COG1832	CoA-binding protein
NtRootA4_03370	COG2315	Protein conserved in bacteria
NtRootA4_03380	COG1653	transport
NtRootA4_03390	COG1175	transmembrane transport
NtRootA4_03400	COG0395	ABC-type sugar transport system, permease component
NtRootA4_03470	COG2368	4-hydroxyphenylacetate
NtRootA4_03550	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NtRootA4_03560	COG3706	GGDEF domain
NtRootA4_03590	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NtRootA4_03600	COG0047	phosphoribosylformylglycinamidine synthase activity
NtRootA4_03640	COG3546	catalase activity
NtRootA4_03650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootA4_03710	COG1846	Transcriptional regulator
NtRootA4_03730	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA4_03750	COG5416	Lipopolysaccharide assembly protein A domain
NtRootA4_03820	COG2847	Copper chaperone PCu(A)C
NtRootA4_03830	COG2837	iron assimilation
NtRootA4_03880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NtRootA4_03900	COG3323	Protein of unknown function (DUF1653)
NtRootA4_03900	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NtRootA4_03920	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA4_03950	COG1846	Transcriptional regulator
NtRootA4_04010	COG0739	heme binding
NtRootA4_04010	COG0741	lytic transglycosylase activity
NtRootA4_04010	COG1196	nuclear chromosome segregation
NtRootA4_04020	COG0386	Belongs to the glutathione peroxidase family
NtRootA4_04030	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NtRootA4_04090	COG1609	Transcriptional regulator
NtRootA4_04110	COG1175	transmembrane transport
NtRootA4_04120	COG0395	ABC-type sugar transport system, permease component
NtRootA4_04150	COG0438	transferase activity, transferring glycosyl groups
NtRootA4_04200	COG1621	beta-fructofuranosidase activity
NtRootA4_04210	COG1609	Transcriptional regulator
NtRootA4_04220	COG0395	ABC-type sugar transport system, permease component
NtRootA4_04260	COG0589	response to stress
NtRootA4_04300	COG3290	protein histidine kinase activity
NtRootA4_04310	COG4565	transcriptional regulatory protein
NtRootA4_04320	COG4702	Belongs to the UPF0303 family
NtRootA4_04340	COG0823	Involved in the tonB-independent uptake of proteins
NtRootA4_04360	COG0673	inositol 2-dehydrogenase activity
NtRootA4_04370	COG0673	inositol 2-dehydrogenase activity
NtRootA4_04390	COG0395	ABC-type sugar transport system, permease component
NtRootA4_04460	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NtRootA4_04480	COG1476	TRANSCRIPTIONal
NtRootA4_04530	COG1309	transcriptional regulator
NtRootA4_04550	COG0351	phosphomethylpyrimidine kinase
NtRootA4_04570	COG0642	Histidine kinase
NtRootA4_04580	COG0745	RESPONSE REGULATOR receiver
NtRootA4_04590	COG0477	Major facilitator Superfamily
NtRootA4_04650	COG0343	queuine tRNA-ribosyltransferase activity
NtRootA4_04730	COG1960	acyl-CoA dehydrogenase activity
NtRootA4_04790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NtRootA4_04810	COG0586	Pfam SNARE associated Golgi protein
NtRootA4_04830	COG0564	pseudouridine synthase activity
NtRootA4_04880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NtRootA4_04890	COG2364	Membrane
NtRootA4_04920	COG1215	transferase activity, transferring glycosyl groups
NtRootA4_04940	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NtRootA4_04950	COG1201	RNA secondary structure unwinding
NtRootA4_05000	COG0569	domain protein
NtRootA4_05000	COG0475	glutathione-regulated potassium exporter activity
NtRootA4_05050	COG0438	transferase activity, transferring glycosyl groups
NtRootA4_05090	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NtRootA4_05170	COG2205	protein histidine kinase activity
NtRootA4_05180	COG0745	RESPONSE REGULATOR receiver
NtRootA4_05200	COG2062	phosphohistidine phosphatase, SixA
NtRootA4_05210	COG0583	DNA-binding transcription factor activity
NtRootA4_05220	COG0697	spore germination
NtRootA4_05240	COG1309	transcriptional regulator
NtRootA4_05250	COG1511	domain protein
NtRootA4_05290	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
NtRootA4_05300	COG1940	carbohydrate kinase activity
NtRootA4_05320	COG4608	Belongs to the ABC transporter superfamily
NtRootA4_05330	COG0444	Belongs to the ABC transporter superfamily
NtRootA4_05340	COG0601	transmembrane transport
NtRootA4_05350	COG0747	negative chemotaxis
NtRootA4_05370	COG1309	transcriptional regulator
NtRootA4_05380	COG0477	Major facilitator Superfamily
NtRootA4_05390	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NtRootA4_05400	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA4_05410	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
NtRootA4_05420	COG1017	nitric oxide dioxygenase activity
NtRootA4_05420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NtRootA4_05470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NtRootA4_05480	COG0514	ATP-dependent DNA helicase (RecQ)
NtRootA4_05490	COG0477	Major facilitator Superfamily
NtRootA4_05500	COG1505	serine-type exopeptidase activity
NtRootA4_05520	COG1113	amino acid transport
NtRootA4_05560	COG0604	alcohol dehydrogenase
NtRootA4_05560	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_05560	COG3321	synthase
NtRootA4_05580	COG1966	Carbon starvation protein
NtRootA4_05620	COG0656	L-ascorbic acid biosynthetic process
NtRootA4_05660	COG0673	inositol 2-dehydrogenase activity
NtRootA4_05670	COG1172	Belongs to the binding-protein-dependent transport system permease family
NtRootA4_05710	COG1609	Transcriptional regulator
NtRootA4_05740	COG0154	amidase activity
NtRootA4_05780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NtRootA4_05840	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NtRootA4_05850	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NtRootA4_05890	COG0588	phosphoglycerate mutase activity
NtRootA4_05950	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NtRootA4_05960	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NtRootA4_05980	COG0215	cysteine-tRNA ligase activity
NtRootA4_06060	COG0366	Alpha amylase catalytic
NtRootA4_06080	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NtRootA4_06110	COG1609	Transcriptional regulator
NtRootA4_06120	COG0366	Alpha amylase catalytic
NtRootA4_06150	COG3833	ABC-type maltose transport systems, permease component
NtRootA4_06160	COG0366	Alpha amylase catalytic
NtRootA4_06170	COG0277	FAD linked oxidase domain protein
NtRootA4_06200	COG0402	S-adenosylhomocysteine deaminase activity
NtRootA4_06210	COG4608	Belongs to the ABC transporter superfamily
NtRootA4_06220	COG0444	Belongs to the ABC transporter superfamily
NtRootA4_06230	COG0601	transmembrane transport
NtRootA4_06250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootA4_06260	COG0402	S-adenosylhomocysteine deaminase activity
NtRootA4_06300	COG3842	ATPase activity
NtRootA4_06400	COG0542	response to heat
NtRootA4_06410	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_06420	COG1609	Transcriptional regulator
NtRootA4_06430	COG0395	ABC-type sugar transport system, permease component
NtRootA4_06440	COG1175	transmembrane transport
NtRootA4_06450	COG1653	transport
NtRootA4_06470	COG1621	beta-fructofuranosidase activity
NtRootA4_06530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NtRootA4_06550	COG3634	alkyl hydroperoxide reductase activity
NtRootA4_06600	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_06620	COG1960	acyl-CoA dehydrogenase activity
NtRootA4_06670	COG0579	oxidoreductase
NtRootA4_06720	COG2957	Belongs to the agmatine deiminase family
NtRootA4_06740	COG0024	Methionine aminopeptidase
NtRootA4_06770	COG0492	ferredoxin-NADP+ reductase activity
NtRootA4_06810	COG0477	Major facilitator Superfamily
NtRootA4_06830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NtRootA4_06830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NtRootA4_06840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NtRootA4_06850	COG0509	glycine decarboxylation via glycine cleavage system
NtRootA4_06860	COG1760	l-serine dehydratase
NtRootA4_06870	COG1864	DNA RNA non-specific endonuclease
NtRootA4_06870	COG3591	Belongs to the peptidase S1B family
NtRootA4_06960	COG0459	protein refolding
NtRootA4_06970	COG0328	RNA-DNA hybrid ribonuclease activity
NtRootA4_06990	COG2205	protein histidine kinase activity
NtRootA4_07000	COG0745	RESPONSE REGULATOR receiver
NtRootA4_07020	COG0583	DNA-binding transcription factor activity
NtRootA4_07040	COG2132	Multicopper oxidase
NtRootA4_07090	COG1278	Cold shock
NtRootA4_07110	COG2814	Major facilitator Superfamily
NtRootA4_07120	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NtRootA4_07140	COG0739	heme binding
NtRootA4_07150	COG0791	NLP P60 protein
NtRootA4_07150	COG3103	Sh3 type 3 domain protein
NtRootA4_07150	COG1388	LysM domain
NtRootA4_07180	COG0746	molybdenum cofactor guanylyltransferase activity
NtRootA4_07210	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NtRootA4_07250	COG1126	abc transporter atp-binding protein
NtRootA4_07260	COG0765	amino acid transport
NtRootA4_07270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA4_07300	COG0488	(ABC) transporter
NtRootA4_07310	COG1132	(ABC) transporter
NtRootA4_07320	COG0494	nUDIX hydrolase
NtRootA4_07390	COG0483	inositol monophosphate 1-phosphatase activity
NtRootA4_07530	COG0045	succinate-CoA ligase (ADP-forming) activity
NtRootA4_07560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NtRootA4_07580	COG3962	Belongs to the TPP enzyme family
NtRootA4_07610	COG0673	inositol 2-dehydrogenase activity
NtRootA4_07620	COG1082	Xylose isomerase domain protein TIM barrel
NtRootA4_07630	COG3718	enzyme involved in inositol metabolism
NtRootA4_07640	COG2188	Transcriptional regulator
NtRootA4_07660	COG1172	Belongs to the binding-protein-dependent transport system permease family
NtRootA4_07710	COG0673	inositol 2-dehydrogenase activity
NtRootA4_07810	COG1396	sequence-specific DNA binding
NtRootA4_07860	COG0028	Belongs to the TPP enzyme family
NtRootA4_07870	COG0477	Major facilitator Superfamily
NtRootA4_07880	COG1234	tRNA 3'-trailer cleavage
NtRootA4_07890	COG0583	DNA-binding transcription factor activity
NtRootA4_07950	COG3142	Participates in the control of copper homeostasis
NtRootA4_08000	COG1401	restriction endodeoxyribonuclease activity
NtRootA4_08030	COG5002	protein histidine kinase activity
NtRootA4_08040	COG0745	RESPONSE REGULATOR receiver
NtRootA4_08060	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA4_08090	COG1024	Enoyl-CoA hydratase
NtRootA4_08100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NtRootA4_08120	COG0477	Major facilitator Superfamily
NtRootA4_08130	COG1396	sequence-specific DNA binding
NtRootA4_08170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NtRootA4_08190	COG3237	CsbD-like
NtRootA4_08200	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_08210	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_08250	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NtRootA4_08270	COG1902	pentaerythritol trinitrate reductase activity
NtRootA4_08300	COG2376	Dihydroxyacetone kinase
NtRootA4_08310	COG0698	ribose 5-phosphate isomerase
NtRootA4_08320	COG1250	3-hydroxyacyl-CoA dehydrogenase
NtRootA4_08330	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_08340	COG2271	Major facilitator Superfamily
NtRootA4_08350	COG0149	triose-phosphate isomerase activity
NtRootA4_08430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NtRootA4_08450	COG1254	Belongs to the acylphosphatase family
NtRootA4_08460	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
NtRootA4_08480	COG1309	transcriptional regulator
NtRootA4_08500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NtRootA4_08510	COG2186	Transcriptional regulator
NtRootA4_08520	COG0477	Major facilitator Superfamily
NtRootA4_08540	COG0640	Transcriptional regulator
NtRootA4_08560	COG4209	transmembrane transport
NtRootA4_08570	COG0395	ABC-type sugar transport system, permease component
NtRootA4_08580	COG1653	transport
NtRootA4_08680	COG1472	Belongs to the glycosyl hydrolase 3 family
NtRootA4_08690	COG0673	inositol 2-dehydrogenase activity
NtRootA4_08720	COG1609	Transcriptional regulator
NtRootA4_08760	COG0477	Major facilitator Superfamily
NtRootA4_08830	COG0640	Transcriptional regulator
NtRootA4_08860	COG1846	Transcriptional regulator
NtRootA4_08870	COG0697	spore germination
NtRootA4_08970	COG2072	flavoprotein involved in K transport
NtRootA4_09000	COG1278	Cold shock
NtRootA4_09080	COG1846	Transcriptional regulator
NtRootA4_09120	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NtRootA4_09140	COG0789	Transcriptional regulator
NtRootA4_09160	COG0484	heat shock protein binding
NtRootA4_09210	COG2271	Major facilitator Superfamily
NtRootA4_09220	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NtRootA4_09260	COG0138	bifunctional purine biosynthesis protein purh
NtRootA4_09280	COG2838	Isocitrate dehydrogenase
NtRootA4_09300	COG3639	organic phosphonate transmembrane transporter activity
NtRootA4_09310	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NtRootA4_09340	COG2188	Transcriptional regulator
NtRootA4_09370	COG0673	inositol 2-dehydrogenase activity
NtRootA4_09380	COG1136	(ABC) transporter
NtRootA4_09400	COG4213	ABC transporter substrate-binding protein
NtRootA4_09420	COG1129	ABC transporter
NtRootA4_09440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NtRootA4_09460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NtRootA4_09480	COG0531	amino acid
NtRootA4_09540	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NtRootA4_09550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NtRootA4_09560	COG1131	(ABC) transporter
NtRootA4_09600	COG0708	Exodeoxyribonuclease III
NtRootA4_09610	COG0180	Tryptophanyl-tRNA synthetase
NtRootA4_09680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NtRootA4_09710	COG2009	succinate dehydrogenase
NtRootA4_09730	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NtRootA4_09730	COG1473	amidohydrolase
NtRootA4_09740	COG1846	Transcriptional regulator
NtRootA4_09750	COG1764	response to oxidative stress
NtRootA4_09760	COG2130	NADP-dependent
NtRootA4_09770	COG1744	ABC transporter substrate-binding protein PnrA-like
NtRootA4_09780	COG3845	ABC transporter
NtRootA4_09790	COG4603	Belongs to the binding-protein-dependent transport system permease family
NtRootA4_09800	COG1079	Belongs to the binding-protein-dependent transport system permease family
NtRootA4_09840	COG0586	Pfam SNARE associated Golgi protein
NtRootA4_09850	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NtRootA4_09860	COG3956	TIGRFAM MazG family protein
NtRootA4_09870	COG0148	phosphopyruvate hydratase activity
NtRootA4_09920	COG1252	NADH dehydrogenase
NtRootA4_09960	COG2205	protein histidine kinase activity
NtRootA4_09970	COG0745	RESPONSE REGULATOR receiver
NtRootA4_10000	COG0577	efflux transmembrane transporter activity
NtRootA4_10000	COG1136	(ABC) transporter
NtRootA4_10010	COG1136	(ABC) transporter
NtRootA4_10010	COG0577	efflux transmembrane transporter activity
NtRootA4_10070	COG0559	Belongs to the binding-protein-dependent transport system permease family
NtRootA4_10090	COG0183	Belongs to the thiolase family
NtRootA4_10100	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NtRootA4_10120	COG2017	converts alpha-aldose to the beta-anomer
NtRootA4_10140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NtRootA4_10160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NtRootA4_10180	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NtRootA4_10210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NtRootA4_10220	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NtRootA4_10290	COG0114	fumarate hydratase activity
NtRootA4_10300	COG0288	reversible hydration of carbon dioxide
NtRootA4_10320	COG1494	fructose-1,6-bisphosphatase
NtRootA4_10340	COG1482	cell wall glycoprotein biosynthetic process
NtRootA4_10460	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NtRootA4_10470	COG1376	ErfK ybiS ycfS ynhG family protein
NtRootA4_10480	COG1357	PFAM Pentapeptide repeats (8 copies)
NtRootA4_10580	COG0714	Associated with various cellular activities
NtRootA4_10590	COG0084	hydrolase, TatD family'
NtRootA4_10600	COG3583	domain protein
NtRootA4_10610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NtRootA4_10620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NtRootA4_10630	COG0488	(ABC) transporter
NtRootA4_10650	COG1309	transcriptional regulator
NtRootA4_10660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NtRootA4_10670	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NtRootA4_10680	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NtRootA4_10690	COG0193	aminoacyl-tRNA hydrolase activity
NtRootA4_10740	COG0822	iron-sulfur transferase activity
NtRootA4_10750	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NtRootA4_10780	COG0702	epimerase
NtRootA4_10800	COG1988	membrane-bound metal-dependent
NtRootA4_10820	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NtRootA4_10840	COG0446	pyridine nucleotide-disulphide oxidoreductase
NtRootA4_10930	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_10970	COG1609	Transcriptional regulator
NtRootA4_10980	COG2814	Major facilitator Superfamily
NtRootA4_11000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NtRootA4_11030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NtRootA4_11050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NtRootA4_11060	COG1621	beta-fructofuranosidase activity
NtRootA4_11120	COG0243	molybdopterin cofactor binding
NtRootA4_11130	COG2223	nitrite transmembrane transporter activity
NtRootA4_11140	COG0477	Major facilitator Superfamily
NtRootA4_11150	COG4770	biotin carboxylase activity
NtRootA4_11160	COG0424	maF-like protein
NtRootA4_11170	COG2409	Drug exporters of the RND superfamily
NtRootA4_11180	COG1309	transcriptional regulator
NtRootA4_11190	COG0393	Putative heavy-metal-binding
NtRootA4_11200	COG1823	symporter activity
NtRootA4_11230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NtRootA4_11240	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_11250	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NtRootA4_11250	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NtRootA4_11300	COG0714	Associated with various cellular activities
NtRootA4_11340	COG0631	protein serine/threonine phosphatase activity
NtRootA4_11380	COG1674	ftsk spoiiie
NtRootA4_11390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NtRootA4_11400	COG0483	inositol monophosphate 1-phosphatase activity
NtRootA4_11420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA4_11460	COG4565	transcriptional regulatory protein
NtRootA4_11480	COG2851	Citrate transporter
NtRootA4_11490	COG1316	TRANSCRIPTIONal
NtRootA4_11510	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NtRootA4_11520	COG0154	amidase activity
NtRootA4_11530	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NtRootA4_11550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NtRootA4_11560	COG4209	transmembrane transport
NtRootA4_11570	COG0395	ABC-type sugar transport system, permease component
NtRootA4_11610	COG0583	DNA-binding transcription factor activity
NtRootA4_11620	COG1063	alcohol dehydrogenase
NtRootA4_11630	COG0156	8-amino-7-oxononanoate synthase activity
NtRootA4_11650	COG1228	amidohydrolase
NtRootA4_11660	COG1470	cell adhesion involved in biofilm formation
NtRootA4_11660	COG0366	Alpha amylase catalytic
NtRootA4_11670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NtRootA4_11720	COG0588	phosphoglycerate mutase activity
NtRootA4_11750	COG2873	o-acetylhomoserine
NtRootA4_11760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NtRootA4_11830	COG0423	glycine-tRNA ligase activity
NtRootA4_11870	COG0390	transport system, permease component
NtRootA4_11880	COG2205	protein histidine kinase activity
NtRootA4_11900	COG0586	Pfam SNARE associated Golgi protein
NtRootA4_11910	COG0671	phosphoesterase, PA-phosphatase related
NtRootA4_11930	COG1131	(ABC) transporter
NtRootA4_11940	COG0842	Transport permease protein
NtRootA4_11950	COG4585	Histidine kinase
NtRootA4_11960	COG2197	response regulator
NtRootA4_11990	COG0358	DNA primase activity
NtRootA4_12010	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NtRootA4_12020	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NtRootA4_12040	COG2814	Major facilitator Superfamily
NtRootA4_12080	COG0297	glycogen (starch) synthase activity
NtRootA4_12110	COG0052	Belongs to the universal ribosomal protein uS2 family
NtRootA4_12120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NtRootA4_12130	COG0528	UMP kinase activity
NtRootA4_12140	COG0233	cytoplasmic translational termination
NtRootA4_12150	COG0575	Belongs to the CDS family
NtRootA4_12180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NtRootA4_12200	COG3279	Response regulator of the LytR AlgR family
NtRootA4_12210	COG3275	phosphorelay sensor kinase activity
NtRootA4_12230	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NtRootA4_12240	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NtRootA4_12240	COG1796	DNA polymerase
NtRootA4_12280	COG1522	sequence-specific DNA binding
NtRootA4_12300	COG0022	dehydrogenase e1 component
NtRootA4_12310	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA4_12320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NtRootA4_12350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NtRootA4_12370	COG1960	acyl-CoA dehydrogenase activity
NtRootA4_12420	COG0673	inositol 2-dehydrogenase activity
NtRootA4_12450	COG0673	inositol 2-dehydrogenase activity
NtRootA4_12470	COG1175	transmembrane transport
NtRootA4_12480	COG1653	transport
NtRootA4_12490	COG1609	Transcriptional regulator
NtRootA4_12510	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NtRootA4_12520	COG0750	zinc metalloprotease
NtRootA4_12540	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NtRootA4_12570	COG1309	transcriptional regulator
NtRootA4_12610	COG0442	prolyl-tRNA aminoacylation
NtRootA4_12660	COG0779	Required for maturation of 30S ribosomal subunits
NtRootA4_12690	COG0481	GTPase activity
NtRootA4_12690	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NtRootA4_12700	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NtRootA4_12710	COG0590	tRNA wobble adenosine to inosine editing
NtRootA4_12730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NtRootA4_12770	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NtRootA4_12780	COG1185	polyribonucleotide nucleotidyltransferase activity
NtRootA4_12790	COG0612	Peptidase, M16
NtRootA4_12830	COG0745	RESPONSE REGULATOR receiver
NtRootA4_12840	COG2205	protein histidine kinase activity
NtRootA4_12880	COG0521	Mo-molybdopterin cofactor biosynthetic process
NtRootA4_12900	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NtRootA4_12940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NtRootA4_12950	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NtRootA4_12960	COG1674	ftsk spoiiie
NtRootA4_12980	COG1058	Belongs to the CinA family
NtRootA4_12980	COG1546	Belongs to the CinA family
NtRootA4_12990	COG1396	sequence-specific DNA binding
NtRootA4_13020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NtRootA4_13030	COG2137	regulation of response to DNA damage stimulus
NtRootA4_13040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NtRootA4_13050	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NtRootA4_13060	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NtRootA4_13070	COG2813	Specifically methylates the guanine in position
NtRootA4_13080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NtRootA4_13100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NtRootA4_13110	COG1388	LysM domain
NtRootA4_13130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NtRootA4_13140	COG0131	Imidazoleglycerol-phosphate dehydratase
NtRootA4_13150	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NtRootA4_13170	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NtRootA4_13220	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NtRootA4_13230	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NtRootA4_13240	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NtRootA4_13250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NtRootA4_13270	COG2814	Major facilitator Superfamily
NtRootA4_13350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NtRootA4_13360	COG0072	phenylalanine-tRNA ligase activity
NtRootA4_13360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NtRootA4_13370	COG3591	Belongs to the peptidase S1B family
NtRootA4_13440	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NtRootA4_13450	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NtRootA4_13460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NtRootA4_13470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NtRootA4_13480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NtRootA4_13490	COG1438	arginine binding
NtRootA4_13500	COG0137	argininosuccinate synthase activity
NtRootA4_13510	COG0165	Argininosuccinate lyase
NtRootA4_13540	COG2094	Belongs to the DNA glycosylase MPG family
NtRootA4_13560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NtRootA4_13600	COG1011	Hydrolase
NtRootA4_13630	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NtRootA4_13640	COG0497	DNA recombination
NtRootA4_13650	COG0504	CTP synthase activity
NtRootA4_13720	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NtRootA4_13730	COG2079	MmgE PrpD family protein
NtRootA4_13760	COG3290	protein histidine kinase activity
NtRootA4_13770	COG1301	dicarboxylic acid transport
NtRootA4_13790	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NtRootA4_13800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NtRootA4_13830	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NtRootA4_13850	COG1160	GTP binding
NtRootA4_13870	COG2814	Major facilitator Superfamily
NtRootA4_13890	COG0509	glycine decarboxylation via glycine cleavage system
NtRootA4_13900	COG1716	ATPase activity
NtRootA4_13950	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NtRootA4_13970	COG1940	carbohydrate kinase activity
NtRootA4_14020	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NtRootA4_14030	COG0515	serine threonine protein kinase
NtRootA4_14030	COG2815	serine threonine protein kinase
NtRootA4_14040	COG1388	LysM domain
NtRootA4_14040	COG3942	CHAP domain
NtRootA4_14070	COG0142	geranyltranstransferase activity
NtRootA4_14100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NtRootA4_14120	COG2001	Belongs to the MraZ family
NtRootA4_14130	COG0275	rRNA processing
NtRootA4_14150	COG0768	penicillin binding
NtRootA4_14160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NtRootA4_14180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NtRootA4_14190	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NtRootA4_14210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NtRootA4_14220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NtRootA4_14240	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NtRootA4_14260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NtRootA4_14270	COG1799	cell septum assembly
NtRootA4_14300	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NtRootA4_14350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NtRootA4_14360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NtRootA4_14370	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_14410	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NtRootA4_14420	COG0174	glutamine synthetase
NtRootA4_14430	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NtRootA4_14500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NtRootA4_14510	COG0321	lipoyl(octanoyl) transferase activity
NtRootA4_14520	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NtRootA4_14520	COG0515	serine threonine protein kinase
NtRootA4_14540	COG4946	Tricorn protease homolog
NtRootA4_14540	COG0793	Belongs to the peptidase S41A family
NtRootA4_14550	COG1764	response to oxidative stress
NtRootA4_14580	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA4_14590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NtRootA4_14600	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NtRootA4_14640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NtRootA4_14700	COG1271	oxidase subunit
NtRootA4_14710	COG1294	oxidase, subunit
NtRootA4_14720	COG4988	ABC transporter
NtRootA4_14760	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NtRootA4_14770	COG1042	CoA-binding domain protein
NtRootA4_14770	COG0045	succinate-CoA ligase (ADP-forming) activity
NtRootA4_14770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NtRootA4_14800	COG1435	thymidine kinase activity
NtRootA4_14850	COG0756	dUTP diphosphatase activity
NtRootA4_14900	COG0569	domain protein
NtRootA4_14920	COG0531	amino acid
NtRootA4_14930	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NtRootA4_14940	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NtRootA4_14950	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NtRootA4_14990	COG0667	Aldo Keto reductase
NtRootA4_15000	COG1024	Enoyl-CoA hydratase
NtRootA4_15000	COG1250	3-hydroxyacyl-CoA dehydrogenase
NtRootA4_15010	COG0183	Belongs to the thiolase family
NtRootA4_15070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NtRootA4_15100	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NtRootA4_15130	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NtRootA4_15140	COG3135	benzoate transporter
NtRootA4_15160	COG0531	amino acid
NtRootA4_15180	COG0242	peptide deformylase activity
NtRootA4_15190	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NtRootA4_15210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NtRootA4_15260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NtRootA4_15260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NtRootA4_15280	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NtRootA4_15290	COG0140	phosphoribosyl-ATP diphosphatase activity
NtRootA4_15300	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NtRootA4_15310	COG0107	imidazoleglycerol-phosphate synthase activity
NtRootA4_15330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NtRootA4_15370	COG0134	indole-3-glycerol-phosphate synthase activity
NtRootA4_15380	COG0133	tryptophan synthase activity
NtRootA4_15390	COG0159	tryptophan synthase activity
NtRootA4_15400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NtRootA4_15410	COG0067	glutamate synthase
NtRootA4_15410	COG0069	glutamate synthase activity
NtRootA4_15410	COG0070	glutamate synthase
NtRootA4_15490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NtRootA4_15500	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA4_15510	COG0145	ligase activity
NtRootA4_15550	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA4_15560	COG0673	inositol 2-dehydrogenase activity
NtRootA4_15570	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_15580	COG0129	dihydroxy-acid dehydratase activity
NtRootA4_15590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootA4_15610	COG0673	inositol 2-dehydrogenase activity
NtRootA4_15630	COG1129	ABC transporter
NtRootA4_15640	COG1172	Belongs to the binding-protein-dependent transport system permease family
NtRootA4_15660	COG0247	lactate metabolic process
NtRootA4_15660	COG0277	FAD linked oxidase domain protein
NtRootA4_15720	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NtRootA4_15750	COG0800	Aldolase
NtRootA4_15770	COG1609	Transcriptional regulator
NtRootA4_15840	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_15860	COG0395	ABC-type sugar transport system, permease component
NtRootA4_15890	COG1760	l-serine dehydratase
NtRootA4_15920	COG2814	Major facilitator Superfamily
NtRootA4_15960	COG1733	regulation of RNA biosynthetic process
NtRootA4_16050	COG0443	Heat shock 70 kDa protein
NtRootA4_16060	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NtRootA4_16090	COG0542	response to heat
NtRootA4_16120	COG0747	negative chemotaxis
NtRootA4_16130	COG0601	transmembrane transport
NtRootA4_16140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootA4_16150	COG0444	Belongs to the ABC transporter superfamily
NtRootA4_16160	COG4608	Belongs to the ABC transporter superfamily
NtRootA4_16180	COG1621	beta-fructofuranosidase activity
NtRootA4_16210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NtRootA4_16220	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_16240	COG0251	oxidation-reduction process
NtRootA4_16290	COG1802	Transcriptional regulator
NtRootA4_16310	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NtRootA4_16330	COG1126	abc transporter atp-binding protein
NtRootA4_16340	COG0765	amino acid transport
NtRootA4_16350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA4_16370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NtRootA4_16380	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA4_16390	COG0473	3-isopropylmalate dehydrogenase activity
NtRootA4_16420	COG1064	alcohol dehydrogenase
NtRootA4_16430	COG0747	negative chemotaxis
NtRootA4_16450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootA4_16460	COG4172	Belongs to the ABC transporter superfamily
NtRootA4_16470	COG1309	transcriptional regulator
NtRootA4_16490	COG3321	synthase
NtRootA4_16490	COG0604	alcohol dehydrogenase
NtRootA4_16660	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NtRootA4_16720	COG1063	alcohol dehydrogenase
NtRootA4_16730	COG2217	Heavy metal translocating P-type atpase
NtRootA4_16750	COG0280	phosphate acetyltransferase
NtRootA4_16750	COG0857	belongs to the CobB CobQ family
NtRootA4_16760	COG0589	response to stress
NtRootA4_16770	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NtRootA4_16800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NtRootA4_16810	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NtRootA4_16830	COG0464	growth
NtRootA4_16960	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA4_17010	COG2828	Protein conserved in bacteria
NtRootA4_17030	COG0673	inositol 2-dehydrogenase activity
NtRootA4_17050	COG0395	ABC-type sugar transport system, permease component
NtRootA4_17080	COG1609	Transcriptional regulator
NtRootA4_17100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NtRootA4_17110	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootA4_17120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NtRootA4_17140	COG0475	glutathione-regulated potassium exporter activity
NtRootA4_17180	COG0028	Belongs to the TPP enzyme family
NtRootA4_17210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NtRootA4_17310	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA4_17320	COG2084	Dehydrogenase
NtRootA4_17330	COG1737	Transcriptional regulator
NtRootA4_17350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NtRootA4_17370	COG3795	YCII-related domain
NtRootA4_17380	COG4941	Belongs to the sigma-70 factor family
NtRootA4_17410	COG1064	alcohol dehydrogenase
NtRootA4_17420	COG1643	Atp-dependent helicase
NtRootA4_17430	COG1228	amidohydrolase
NtRootA4_17500	COG0009	L-threonylcarbamoyladenylate synthase
NtRootA4_17540	COG2971	BadF BadG BcrA BcrD
NtRootA4_17560	COG1414	Transcriptional regulator
NtRootA4_17580	COG1053	succinate dehydrogenase
NtRootA4_17600	COG0477	Major facilitator Superfamily
NtRootA4_17630	COG3483	tryptophan 2,3-dioxygenase activity
NtRootA4_17700	COG2050	protein possibly involved in aromatic compounds catabolism
NtRootA4_17720	COG4552	Acetyltransferase involved in intracellular survival and related
NtRootA4_17740	COG0539	negative regulation of cytoplasmic translation
NtRootA4_17750	COG1739	Uncharacterized protein family UPF0029
NtRootA4_17760	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NtRootA4_17760	COG0237	dephospho-CoA kinase activity
NtRootA4_17770	COG0556	nucleotide-excision repair
NtRootA4_17790	COG0477	Major facilitator Superfamily
NtRootA4_17810	COG0456	acetyltransferase
NtRootA4_17820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NtRootA4_17840	COG4106	trans-aconitate 2-methyltransferase activity
NtRootA4_17870	COG0546	phosphoglycolate phosphatase activity
NtRootA4_17890	COG0322	excinuclease ABC activity
NtRootA4_17900	COG1660	Displays ATPase and GTPase activities
NtRootA4_17920	COG1481	regulation of sporulation
NtRootA4_17930	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NtRootA4_17940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NtRootA4_17950	COG0126	phosphoglycerate kinase activity
NtRootA4_17960	COG0149	triose-phosphate isomerase activity
NtRootA4_17970	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NtRootA4_17990	COG0363	glucosamine-6-phosphate deaminase activity
NtRootA4_18020	COG0166	Belongs to the GPI family
NtRootA4_18030	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NtRootA4_18050	COG0109	protoheme IX farnesyltransferase activity
NtRootA4_18090	COG1136	(ABC) transporter
NtRootA4_18090	COG0577	efflux transmembrane transporter activity
NtRootA4_18100	COG1612	heme a metabolic process
NtRootA4_18110	COG0842	Transport permease protein
NtRootA4_18120	COG1131	(ABC) transporter
NtRootA4_18150	COG0719	Fe-S assembly protein
NtRootA4_18170	COG0396	ATPase activity
NtRootA4_18180	COG2151	metal-sulfur cluster biosynthetic enzyme
NtRootA4_18200	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootA4_18230	COG1122	ATPase activity
NtRootA4_18240	COG1268	BioY protein
NtRootA4_18250	COG0488	(ABC) transporter
NtRootA4_18300	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_18310	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_18320	COG1129	ABC transporter
NtRootA4_18350	COG0560	Phosphoserine phosphatase
NtRootA4_18350	COG3830	Belongs to the UPF0237 family
NtRootA4_18360	COG1119	ATPase activity
NtRootA4_18390	COG0254	rRNA binding
NtRootA4_18400	COG0095	Lipoate-protein ligase
NtRootA4_18440	COG2855	membrane
NtRootA4_18490	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NtRootA4_18500	COG0297	glycogen (starch) synthase activity
NtRootA4_18530	COG0183	Belongs to the thiolase family
NtRootA4_18560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NtRootA4_18600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NtRootA4_18610	COG0673	inositol 2-dehydrogenase activity
NtRootA4_18620	COG1088	dTDP-glucose 4,6-dehydratase activity
NtRootA4_18630	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NtRootA4_18760	COG1088	dTDP-glucose 4,6-dehydratase activity
NtRootA4_18770	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NtRootA4_18780	COG0667	Aldo Keto reductase
NtRootA4_18790	COG1968	undecaprenyl-diphosphatase activity
NtRootA4_18800	COG0215	cysteine-tRNA ligase activity
NtRootA4_18820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NtRootA4_18830	COG0517	IMP dehydrogenase activity
NtRootA4_18830	COG1994	Peptidase M50
NtRootA4_18850	COG1222	aaa ATPase
NtRootA4_18860	COG4122	O-methyltransferase activity
NtRootA4_18880	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NtRootA4_18890	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NtRootA4_18900	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NtRootA4_18910	COG0545	Peptidyl-prolyl cis-trans isomerase
NtRootA4_18950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NtRootA4_18960	COG0805	protein transport
NtRootA4_18970	COG4581	dead DEAH box helicase
NtRootA4_18980	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NtRootA4_18990	COG1216	Glycosyl transferase, family 2
NtRootA4_19040	COG0823	Involved in the tonB-independent uptake of proteins
NtRootA4_19040	COG1506	peptidase
NtRootA4_19040	COG4946	Tricorn protease homolog
NtRootA4_19050	COG0242	peptide deformylase activity
NtRootA4_19090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NtRootA4_19100	COG3424	synthase
NtRootA4_19110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NtRootA4_19190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NtRootA4_19200	COG1845	cytochrome c oxidase, subunit III
NtRootA4_19210	COG2010	Cytochrome c
NtRootA4_19220	COG0723	plastoquinol--plastocyanin reductase activity
NtRootA4_19230	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NtRootA4_19260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NtRootA4_19280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NtRootA4_19290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NtRootA4_19330	COG0167	dihydroorotate dehydrogenase activity
NtRootA4_19370	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NtRootA4_19380	COG1381	Involved in DNA repair and RecF pathway recombination
NtRootA4_19390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NtRootA4_19400	COG3590	peptidase
NtRootA4_19410	COG1316	TRANSCRIPTIONal
NtRootA4_19420	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NtRootA4_19440	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NtRootA4_19480	COG0484	heat shock protein binding
NtRootA4_19490	COG1420	regulation of RNA biosynthetic process
NtRootA4_19520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NtRootA4_19530	COG0481	GTPase activity
NtRootA4_19550	COG0268	Binds directly to 16S ribosomal RNA
NtRootA4_19600	COG1307	EDD domain protein, DegV family
NtRootA4_19610	COG0495	leucyl-tRNA aminoacylation
NtRootA4_19620	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NtRootA4_19630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NtRootA4_19640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NtRootA4_19660	COG2390	Transcriptional regulator
NtRootA4_19670	COG0656	L-ascorbic acid biosynthetic process
NtRootA4_19690	COG0438	transferase activity, transferring glycosyl groups
NtRootA4_19710	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NtRootA4_19730	COG1758	RNA polymerase activity
NtRootA4_19740	COG0194	GDP metabolic process
NtRootA4_19760	COG0284	orotidine-5'-phosphate decarboxylase activity
NtRootA4_19770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NtRootA4_19780	COG0505	Belongs to the CarA family
NtRootA4_19800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NtRootA4_19810	COG0540	Belongs to the ATCase OTCase family
NtRootA4_19820	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NtRootA4_19840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NtRootA4_19850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NtRootA4_19870	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NtRootA4_19880	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NtRootA4_19890	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NtRootA4_19900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NtRootA4_19930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NtRootA4_19960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NtRootA4_20000	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NtRootA4_20010	COG0124	histidyl-tRNA synthetase
NtRootA4_20030	COG1196	nuclear chromosome segregation
NtRootA4_20050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NtRootA4_20060	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NtRootA4_20070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NtRootA4_20090	COG2255	four-way junction helicase activity
NtRootA4_20100	COG0632	four-way junction helicase activity
NtRootA4_20110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NtRootA4_20120	COG0217	transcriptional regulatory protein
NtRootA4_20130	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NtRootA4_20170	COG0339	signal peptide processing
NtRootA4_20180	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NtRootA4_20190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NtRootA4_20210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NtRootA4_20220	COG0587	DNA-directed DNA polymerase activity
NtRootA4_20270	COG2135	peptidase activity
NtRootA4_20300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NtRootA4_20360	COG0644	oxidoreductase
NtRootA4_20390	COG4804	nuclease activity
NtRootA4_20410	COG3842	ATPase activity
NtRootA4_20440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NtRootA4_20450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NtRootA4_20460	COG1780	Probably involved in ribonucleotide reductase function
NtRootA4_20480	COG0583	DNA-binding transcription factor activity
NtRootA4_20550	COG0714	Associated with various cellular activities
NtRootA4_20580	COG1175	transmembrane transport
NtRootA4_20610	COG2813	Specifically methylates the guanine in position
NtRootA4_20640	COG0799	negative regulation of ribosome biogenesis
NtRootA4_20660	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NtRootA4_20680	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NtRootA4_20690	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NtRootA4_20700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NtRootA4_20710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NtRootA4_20720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NtRootA4_20730	COG0351	phosphomethylpyrimidine kinase
NtRootA4_20730	COG0352	thiamine-phosphate diphosphorylase activity
NtRootA4_20730	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NtRootA4_20740	COG1530	ribonuclease E activity
NtRootA4_20760	COG0105	UTP biosynthetic process
NtRootA4_20780	COG0285	dihydrofolate synthase activity
NtRootA4_20790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NtRootA4_20820	COG0525	valine-tRNA ligase activity
NtRootA4_20830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NtRootA4_20840	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NtRootA4_20850	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NtRootA4_20860	COG0740	serine-type endopeptidase activity
NtRootA4_20870	COG0740	serine-type endopeptidase activity
NtRootA4_20880	COG0544	peptidyl-prolyl cis-trans isomerase activity
NtRootA4_20950	COG0668	transmembrane transport
NtRootA4_20980	COG1946	Acyl-CoA thioesterase
NtRootA4_21030	COG0629	single-stranded DNA binding
NtRootA4_21070	COG0242	peptide deformylase activity
NtRootA4_21120	COG3022	response to hydroperoxide
NtRootA4_21140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NtRootA4_21150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NtRootA4_21170	COG1045	serine acetyltransferase
NtRootA4_21180	COG0300	oxidoreductase activity
NtRootA4_21190	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NtRootA4_21210	COG1063	alcohol dehydrogenase
NtRootA4_21220	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_21240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootA4_21260	COG0477	Major facilitator Superfamily
NtRootA4_21330	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NtRootA4_21360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NtRootA4_21370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NtRootA4_21400	COG4974	Belongs to the 'phage' integrase family
NtRootA4_21430	COG0792	nuclease activity
NtRootA4_21450	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NtRootA4_21470	COG0681	Belongs to the peptidase S26 family
NtRootA4_21480	COG0335	large ribosomal subunit rRNA binding
NtRootA4_21490	COG0336	Belongs to the RNA methyltransferase TrmD family
NtRootA4_21500	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NtRootA4_21510	COG1837	Belongs to the UPF0109 family
NtRootA4_21520	COG0228	four-way junction DNA binding
NtRootA4_21540	COG2514	catechol 2,3-dioxygenase activity
NtRootA4_21590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NtRootA4_21620	COG2814	Major facilitator Superfamily
NtRootA4_21690	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NtRootA4_21700	COG0571	ribonuclease III activity
NtRootA4_21710	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NtRootA4_21730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NtRootA4_21760	COG0742	ribosomal rna small subunit methyltransferase
NtRootA4_21780	COG1461	Dihydroxyacetone kinase
NtRootA4_21810	COG1181	Belongs to the D-alanine--D-alanine ligase family
NtRootA4_21820	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NtRootA4_21840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NtRootA4_21850	COG0066	3-isopropylmalate dehydratase activity
NtRootA4_21860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NtRootA4_21870	COG1414	Transcriptional regulator
NtRootA4_21920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NtRootA4_21930	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA4_21940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NtRootA4_21960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NtRootA4_21970	COG0473	3-isopropylmalate dehydrogenase activity
NtRootA4_21980	COG4585	Histidine kinase
NtRootA4_21990	COG2197	response regulator
NtRootA4_22000	COG0577	efflux transmembrane transporter activity
NtRootA4_22000	COG1136	(ABC) transporter
NtRootA4_22030	COG0577	efflux transmembrane transporter activity
NtRootA4_22030	COG1136	(ABC) transporter
NtRootA4_22050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootA4_22060	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NtRootA4_22070	COG0440	acetolactate synthase activity
NtRootA4_22090	COG0129	dihydroxy-acid dehydratase activity
NtRootA4_22110	COG0088	Forms part of the polypeptide exit tunnel
NtRootA4_22150	COG0747	negative chemotaxis
NtRootA4_22160	COG0579	oxidoreductase
NtRootA4_22170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NtRootA4_22180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA4_22200	COG1305	Transglutaminase-like
NtRootA4_22240	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA4_22260	COG1104	cysteine desulfurase activity
NtRootA4_22280	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NtRootA4_22290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NtRootA4_22310	COG1522	sequence-specific DNA binding
NtRootA4_22320	COG1113	amino acid transport
NtRootA4_22340	COG0022	dehydrogenase e1 component
NtRootA4_22350	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA4_22390	COG0477	Major facilitator Superfamily
NtRootA4_22400	COG1414	Transcriptional regulator
NtRootA4_22450	COG1116	anion transmembrane transporter activity
NtRootA4_22460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NtRootA4_22490	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NtRootA4_22520	COG0419	ATPase involved in DNA repair
NtRootA4_22530	COG0420	3'-5' exonuclease activity
NtRootA4_22560	COG2149	membrane
NtRootA4_22610	COG1131	(ABC) transporter
NtRootA4_22640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NtRootA4_22650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NtRootA4_22660	COG1234	tRNA 3'-trailer cleavage
NtRootA4_22670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NtRootA4_22690	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NtRootA4_22710	COG1335	isochorismatase
NtRootA4_22740	COG0363	glucosamine-6-phosphate deaminase activity
NtRootA4_22770	COG1902	pentaerythritol trinitrate reductase activity
NtRootA4_22830	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
NtRootA4_22840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NtRootA4_22860	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NtRootA4_22870	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NtRootA4_22890	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NtRootA4_22900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NtRootA4_22910	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NtRootA4_22920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NtRootA4_22930	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NtRootA4_22940	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NtRootA4_22950	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NtRootA4_22960	COG0356	it plays a direct role in the translocation of protons across the membrane
NtRootA4_23000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NtRootA4_23030	COG0009	L-threonylcarbamoyladenylate synthase
NtRootA4_23040	COG2890	protein-(glutamine-N5) methyltransferase activity
NtRootA4_23050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NtRootA4_23070	COG0083	homoserine kinase activity
NtRootA4_23080	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NtRootA4_23090	COG0460	homoserine dehydrogenase
NtRootA4_23100	COG0019	diaminopimelate decarboxylase activity
NtRootA4_23110	COG0018	arginyl-trna synthetase
NtRootA4_23150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NtRootA4_23150	COG1017	nitric oxide dioxygenase activity
NtRootA4_23210	COG1643	Atp-dependent helicase
NtRootA4_23220	COG0537	adenosine 5'-monophosphoramidase activity
NtRootA4_23230	COG1064	alcohol dehydrogenase
NtRootA4_23270	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NtRootA4_23300	COG1121	(ABC) transporter
NtRootA4_23310	COG0803	Belongs to the bacterial solute-binding protein 9 family
NtRootA4_23330	COG1253	flavin adenine dinucleotide binding
NtRootA4_23340	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA4_23340	COG0567	Dehydrogenase, E1 component
NtRootA4_23410	COG1595	DNA-templated transcription, initiation
NtRootA4_23430	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NtRootA4_23450	COG0483	inositol monophosphate 1-phosphatase activity
NtRootA4_23460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NtRootA4_23520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NtRootA4_23540	COG2177	Part of the ABC transporter FtsEX involved in
NtRootA4_23550	COG2884	Cell division ATP-binding protein ftsE
NtRootA4_23560	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NtRootA4_23690	COG1216	Glycosyl transferase, family 2
NtRootA4_23740	COG1216	Glycosyl transferase, family 2
NtRootA4_23790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NtRootA4_23820	COG0433	COG0433 Predicted ATPase
NtRootA4_23820	COG1674	ftsk spoiiie
NtRootA4_23860	COG2902	Dehydrogenase
NtRootA4_23930	COG0653	protein targeting
NtRootA4_23940	COG3214	Protein conserved in bacteria
NtRootA4_23950	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NtRootA4_23980	COG5401	PFAM Sporulation and spore germination
NtRootA4_23990	COG5002	protein histidine kinase activity
NtRootA4_24040	COG0714	Associated with various cellular activities
NtRootA4_24110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootA4_24120	COG0601	transmembrane transport
NtRootA4_24160	COG0482	sulfurtransferase activity
NtRootA4_24170	COG1053	succinate dehydrogenase
NtRootA4_24200	COG1902	pentaerythritol trinitrate reductase activity
NtRootA4_24200	COG0446	pyridine nucleotide-disulphide oxidoreductase
NtRootA4_24210	COG0673	inositol 2-dehydrogenase activity
NtRootA4_24230	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NtRootA4_24240	COG0477	Major facilitator Superfamily
NtRootA4_24250	COG0583	DNA-binding transcription factor activity
NtRootA4_24290	COG0484	heat shock protein binding
NtRootA4_24300	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NtRootA4_24310	COG1595	DNA-templated transcription, initiation
NtRootA4_24340	COG3265	gluconokinase activity
NtRootA4_24350	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NtRootA4_24360	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NtRootA4_24370	COG2086	electron transfer activity
NtRootA4_24380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NtRootA4_24410	COG1842	Phage shock protein A
NtRootA4_24430	COG1615	UPF0182 protein
NtRootA4_24440	COG3480	Lon protease (S16) C-terminal proteolytic domain
NtRootA4_24480	COG2816	NAD+ diphosphatase activity
NtRootA4_24540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA4_24550	COG0765	amino acid transport
NtRootA4_24560	COG1126	abc transporter atp-binding protein
NtRootA4_24590	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NtRootA4_24610	COG0113	porphobilinogen synthase activity
NtRootA4_24630	COG0181	hydroxymethylbilane synthase activity
NtRootA4_24640	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NtRootA4_24650	COG3253	May function as heme-dependent peroxidase
NtRootA4_24660	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NtRootA4_24670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NtRootA4_24680	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NtRootA4_24710	COG1309	transcriptional regulator
NtRootA4_24770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NtRootA4_24770	COG2022	thiamine diphosphate biosynthetic process
NtRootA4_24780	COG0352	thiamine-phosphate diphosphorylase activity
NtRootA4_24800	COG2267	carboxylic ester hydrolase activity
NtRootA4_24820	COG0513	Belongs to the DEAD box helicase family
NtRootA4_24840	COG2095	MarC family integral membrane protein
NtRootA4_24860	COG0006	proline dipeptidase activity
NtRootA4_24880	COG2239	Acts as a magnesium transporter
NtRootA4_24910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NtRootA4_24930	COG1595	DNA-templated transcription, initiation
NtRootA4_24990	COG1126	abc transporter atp-binding protein
NtRootA4_25000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA4_25010	COG0765	amino acid transport
NtRootA4_25020	COG0765	amino acid transport
NtRootA4_25030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NtRootA4_25040	COG2171	N-acyltransferase activity
NtRootA4_25070	COG3226	Transcriptional regulator
NtRootA4_25080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NtRootA4_25140	COG1217	gtp-binding protein TYPA
NtRootA4_25170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootA4_25190	COG4166	transmembrane transport
NtRootA4_25210	COG0012	GTP binding
NtRootA4_25220	COG1322	Protein conserved in bacteria
NtRootA4_25230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NtRootA4_25250	COG1570	exodeoxyribonuclease VII activity
NtRootA4_25260	COG1722	exodeoxyribonuclease VII activity
NtRootA4_25270	COG2326	polyphosphate kinase activity
NtRootA4_25310	COG1174	glycine betaine transport
NtRootA4_25330	COG1162	GTPase activity
NtRootA4_25380	COG2971	BadF BadG BcrA BcrD
NtRootA4_25410	COG0583	DNA-binding transcription factor activity
NtRootA4_25420	COG2814	Major facilitator Superfamily
NtRootA4_25430	COG3548	integral membrane protein
NtRootA4_25490	COG0598	Magnesium transport protein CorA
NtRootA4_25510	COG1528	Iron-storage protein
NtRootA4_25520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NtRootA4_25530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NtRootA4_25550	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NtRootA4_25560	COG1695	Transcriptional regulator
NtRootA4_25750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NtRootA4_25860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NtRootA4_25870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NtRootA4_25880	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NtRootA4_25920	COG0519	Catalyzes the synthesis of GMP from XMP
NtRootA4_25920	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NtRootA4_25960	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NtRootA4_25970	COG0516	GMP reductase activity
NtRootA4_26010	COG1132	(ABC) transporter
NtRootA4_26050	COG0459	protein refolding
NtRootA4_26060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NtRootA4_26090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NtRootA4_26100	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NtRootA4_26120	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NtRootA4_26130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NtRootA4_26160	COG0802	atpase or kinase
NtRootA4_26170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NtRootA4_26210	COG0438	transferase activity, transferring glycosyl groups
NtRootA4_26220	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NtRootA4_26240	COG0667	Aldo Keto reductase
NtRootA4_26290	COG0736	holo-[acyl-carrier-protein] synthase activity
NtRootA4_26310	COG1072	(Pantothenic acid kinase))
NtRootA4_26330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NtRootA4_26340	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NtRootA4_26350	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NtRootA4_26390	COG2894	cell division
NtRootA4_26450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NtRootA4_26470	COG0101	tRNA pseudouridine synthase activity
NtRootA4_26480	COG0203	ribosomal protein L17
NtRootA4_26490	COG0202	RNA polymerase activity
NtRootA4_26500	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NtRootA4_26510	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NtRootA4_26520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NtRootA4_26530	COG3191	aminopeptidase activity
NtRootA4_26590	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootA4_26600	COG2124	cytochrome p450
NtRootA4_26610	COG1216	Glycosyl transferase, family 2
NtRootA4_26620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NtRootA4_26630	COG0563	adenylate kinase activity
NtRootA4_26650	COG0200	Binds to the 23S rRNA
NtRootA4_26660	COG1841	ribosomal large subunit assembly
NtRootA4_26670	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NtRootA4_26690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NtRootA4_26700	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NtRootA4_26710	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NtRootA4_26720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NtRootA4_26730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NtRootA4_26740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NtRootA4_26750	COG0255	Belongs to the universal ribosomal protein uL29 family
NtRootA4_26760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NtRootA4_26770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NtRootA4_26780	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NtRootA4_26790	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NtRootA4_26800	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NtRootA4_26810	COG0089	rRNA binding
NtRootA4_26820	COG0088	Forms part of the polypeptide exit tunnel
NtRootA4_26830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NtRootA4_26840	COG0051	transcription antitermination factor activity, RNA binding
NtRootA4_26880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NtRootA4_26890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NtRootA4_26900	COG0049	tRNA binding
NtRootA4_26910	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NtRootA4_26920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NtRootA4_26930	COG0085	RNA polymerase activity
NtRootA4_26940	COG0183	Belongs to the thiolase family
NtRootA4_26950	COG0442	prolyl-tRNA aminoacylation
NtRootA4_26960	COG0222	ribosome binding
NtRootA4_26970	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NtRootA4_27010	COG0081	regulation of translation
NtRootA4_27020	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NtRootA4_27050	COG0436	Aminotransferase
NtRootA4_27060	COG2197	response regulator
NtRootA4_27180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NtRootA4_27200	COG3485	protocatechuate 3,4-dioxygenase
NtRootA4_27230	COG0745	RESPONSE REGULATOR receiver
NtRootA4_27240	COG0456	acetyltransferase
NtRootA4_27250	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NtRootA4_27260	COG0494	nUDIX hydrolase
NtRootA4_27260	COG0406	alpha-ribazole phosphatase activity
NtRootA4_27300	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NtRootA4_27310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NtRootA4_27330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NtRootA4_27370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NtRootA4_27380	COG0738	Major facilitator superfamily
NtRootA4_27400	COG2030	dehydratase
NtRootA4_27460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NtRootA4_27480	COG4989	oxidoreductase activity
NtRootA4_27490	COG0366	Alpha amylase catalytic
NtRootA4_27500	COG0395	ABC-type sugar transport system, permease component
NtRootA4_27510	COG1175	transmembrane transport
NtRootA4_27540	COG1940	carbohydrate kinase activity
NtRootA4_27570	COG1376	ErfK ybiS ycfS ynhG family protein
NtRootA4_27630	COG0754	glutathionylspermidine amidase activity
NtRootA4_27650	COG5650	phosphatidylinositol metabolic process
NtRootA4_27690	COG1175	transmembrane transport
NtRootA4_27700	COG0395	ABC-type sugar transport system, permease component
NtRootA4_27750	COG5650	phosphatidylinositol metabolic process
NtRootA4_27810	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootA4_27830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NtRootA4_27840	COG1309	transcriptional regulator
NtRootA4_27850	COG1131	(ABC) transporter
NtRootA4_27890	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NtRootA4_27910	COG1666	GTP binding
NtRootA4_27920	COG0672	)-iron permease
NtRootA4_27940	COG2837	iron assimilation
NtRootA4_27970	COG0501	Belongs to the peptidase M48B family
NtRootA4_28030	COG0531	amino acid
NtRootA4_28130	COG0395	ABC-type sugar transport system, permease component
NtRootA4_28140	COG4209	transmembrane transport
NtRootA4_28160	COG1609	Transcriptional regulator
NtRootA4_28200	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA4_28210	COG3835	regulator
NtRootA4_28220	COG2807	transmembrane transport
NtRootA4_28230	COG2186	Transcriptional regulator
NtRootA4_28240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NtRootA4_28240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NtRootA4_28260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NtRootA4_28260	COG1648	precorrin-2 dehydrogenase activity
NtRootA4_28270	COG2066	Belongs to the glutaminase family
NtRootA4_28280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA4_28330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NtRootA4_28340	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NtRootA4_28360	COG2040	homocysteine
NtRootA4_28370	COG2895	sulfate adenylyltransferase (ATP) activity
NtRootA4_28390	COG0175	sulfate reduction
NtRootA4_28420	COG2860	membrane
NtRootA4_28450	COG0142	geranyltranstransferase activity
NtRootA4_28470	COG2226	methyltransferase
NtRootA4_28480	COG1169	isochorismate synthase
NtRootA4_28490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA4_28500	COG0765	amino acid transport
NtRootA4_28530	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NtRootA4_28550	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootA4_28610	COG0395	ABC-type sugar transport system, permease component
NtRootA4_28620	COG1175	transmembrane transport
NtRootA4_28710	COG1404	Belongs to the peptidase S8 family
NtRootA4_28770	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA4_28780	COG0022	dehydrogenase e1 component
NtRootA4_28820	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NtRootA4_28840	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NtRootA4_28850	COG1088	dTDP-glucose 4,6-dehydratase activity
NtRootA4_28870	COG0489	protein tyrosine kinase activity
NtRootA4_28950	COG0438	transferase activity, transferring glycosyl groups
NtRootA4_28950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NtRootA4_28970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NtRootA4_29050	COG2267	carboxylic ester hydrolase activity
NtRootA4_29070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NtRootA4_29080	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NtRootA4_29090	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NtRootA4_29100	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NtRootA4_29230	COG1846	Transcriptional regulator
NtRootA4_29240	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NtRootA4_29280	COG1063	alcohol dehydrogenase
NtRootA4_29310	COG0667	Aldo Keto reductase
NtRootA4_29370	COG1024	Enoyl-CoA hydratase
NtRootA4_29380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NtRootA4_29390	COG2151	metal-sulfur cluster biosynthetic enzyme
NtRootA4_29400	COG3396	Phenylacetate-CoA oxygenase
NtRootA4_29410	COG3460	Phenylacetate-CoA oxygenase
NtRootA4_29420	COG3396	Phenylacetate-CoA oxygenase
NtRootA4_29430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NtRootA4_29440	COG1388	LysM domain
NtRootA4_29440	COG3942	CHAP domain
NtRootA4_29460	COG3706	GGDEF domain
NtRootA4_29490	COG0438	transferase activity, transferring glycosyl groups
NtRootA4_29510	COG0438	transferase activity, transferring glycosyl groups
NtRootA4_29540	COG2226	methyltransferase
NtRootA4_29560	COG5002	protein histidine kinase activity
NtRootA4_29610	COG2050	protein possibly involved in aromatic compounds catabolism
NtRootA4_29640	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA4_29640	COG2030	dehydratase
NtRootA4_29670	COG1250	3-hydroxyacyl-CoA dehydrogenase
NtRootA4_29680	COG1024	Enoyl-CoA hydratase
NtRootA4_29740	COG1266	CAAX protease self-immunity
NtRootA4_29760	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NtRootA4_29860	COG0443	Heat shock 70 kDa protein
NtRootA4_29870	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NtRootA4_29890	COG0785	Cytochrome C biogenesis protein
NtRootA4_29910	COG0406	alpha-ribazole phosphatase activity
NtRootA4_29970	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NtRootA4_30020	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NtRootA4_30030	COG3458	cephalosporin-C deacetylase activity
NtRootA4_30050	COG2814	Major facilitator Superfamily
NtRootA4_30070	COG0395	ABC-type sugar transport system, permease component
NtRootA4_30080	COG1175	transmembrane transport
NtRootA4_30120	COG0395	ABC-type sugar transport system, permease component
NtRootA4_30130	COG1175	transmembrane transport
NtRootA4_30150	COG0673	inositol 2-dehydrogenase activity
NtRootA4_30180	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootA4_30190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NtRootA4_30210	COG0673	inositol 2-dehydrogenase activity
NtRootA4_30220	COG1609	Transcriptional regulator
NtRootA4_30250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NtRootA4_30260	COG0640	Transcriptional regulator
NtRootA4_30280	COG0123	including yeast histone deacetylase and acetoin utilization protein
NtRootA4_30290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NtRootA4_30300	COG0569	domain protein
NtRootA4_30310	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NtRootA4_30320	COG1082	Xylose isomerase domain protein TIM barrel
NtRootA4_30330	COG0248	Ppx GppA phosphatase
NtRootA4_30350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NtRootA4_30350	COG1754	DNA topoisomerase type I activity
NtRootA4_30400	COG1054	Belongs to the UPF0176 family
NtRootA4_30420	COG1205	dead DEAH box helicase
NtRootA4_30420	COG1111	helicase
NtRootA4_30560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NtRootA4_30570	COG1349	DNA-binding transcription factor activity
NtRootA4_30600	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA4_30610	COG1609	Transcriptional regulator
NtRootA4_30630	COG1175	transmembrane transport
NtRootA4_30640	COG0395	ABC-type sugar transport system, permease component
NtRootA4_30730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NtRootA4_30740	COG1408	metallophosphoesterase
NtRootA4_30750	COG1132	(ABC) transporter
NtRootA4_30760	COG1132	(ABC) transporter
NtRootA4_30810	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NtRootA4_30820	COG0151	Belongs to the GarS family
NtRootA4_30850	COG1301	dicarboxylic acid transport
NtRootA4_30870	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_30890	COG1953	Uracil, thiamine, allantoin
NtRootA4_30900	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NtRootA4_30930	COG0454	-acetyltransferase
NtRootA4_30940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NtRootA4_30960	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NtRootA4_30960	COG3608	succinylglutamate desuccinylase aspartoacylase
NtRootA4_30970	COG2252	PERMEase
NtRootA4_30980	COG0590	tRNA wobble adenosine to inosine editing
NtRootA4_31050	COG2233	PERMEase
NtRootA4_31060	COG1414	Transcriptional regulator
NtRootA4_31080	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NtRootA4_31100	COG3257	ureidoglycine aminohydrolase activity
NtRootA4_31130	COG0395	ABC-type sugar transport system, permease component
NtRootA4_31150	COG1653	transport
NtRootA4_31170	COG3119	arylsulfatase activity
NtRootA4_31180	COG1609	Transcriptional regulator
NtRootA4_31190	COG5492	domain, Protein
NtRootA4_31200	COG3654	unkown
NtRootA4_31220	COG2318	DinB family
NtRootA4_31280	COG2271	Major facilitator Superfamily
NtRootA4_31310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NtRootA4_31310	COG4499	WXG100 protein secretion system (Wss), protein YukC
NtRootA4_31330	COG2814	Major facilitator Superfamily
NtRootA4_31360	COG0659	secondary active sulfate transmembrane transporter activity
NtRootA4_31440	COG0563	adenylate kinase activity
NtRootA4_31460	COG0477	Major facilitator Superfamily
NtRootA4_31480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NtRootA4_31500	COG3401	FG-GAP repeat protein
NtRootA4_31510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA4_31550	COG2011	ABC-type metal ion transport system permease component
NtRootA4_31560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NtRootA4_31570	COG1464	Belongs to the NlpA lipoprotein family
NtRootA4_31580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA4_31670	COG2267	carboxylic ester hydrolase activity
NtRootA4_31730	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NtRootA4_31740	COG1733	regulation of RNA biosynthetic process
NtRootA4_31750	COG3025	triphosphatase activity
NtRootA4_31750	COG5607	PFAM CHAD domain containing protein
NtRootA4_31830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NtRootA4_31910	COG0405	Gamma-glutamyltransferase
NtRootA4_32020	COG0673	inositol 2-dehydrogenase activity
NtRootA4_32040	COG0673	inositol 2-dehydrogenase activity
NtRootA4_32070	COG1653	transport
NtRootA4_32080	COG1609	Transcriptional regulator
NtRootA4_32150	COG3622	Belongs to the hyi family
NtRootA4_32160	COG2084	Dehydrogenase
NtRootA4_32170	COG3960	tartronate-semialdehyde synthase activity
NtRootA4_32180	COG1929	Belongs to the glycerate kinase type-1 family
NtRootA4_32190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NtRootA4_32200	COG0745	RESPONSE REGULATOR receiver
NtRootA4_32220	COG0745	RESPONSE REGULATOR receiver
NtRootA4_32230	COG1215	transferase activity, transferring glycosyl groups
NtRootA4_32240	COG1366	Belongs to the anti-sigma-factor antagonist family
NtRootA4_32260	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NtRootA4_32300	COG2814	Major facilitator Superfamily
NtRootA4_32320	COG0671	phosphoesterase, PA-phosphatase related
NtRootA4_32350	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA4_32380	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NtRootA4_32420	COG0542	response to heat
NtRootA4_32470	COG3585	molybdate ion transport
NtRootA4_32480	COG4585	Histidine kinase
NtRootA4_32490	COG2197	response regulator
NtRootA4_32550	COG3304	Inner membrane component domain
NtRootA4_32560	COG0135	phosphoribosylanthranilate isomerase activity
NtRootA4_32600	COG0667	Aldo Keto reductase
NtRootA4_32630	COG2814	Major facilitator Superfamily
NtRootA4_32650	COG2813	Specifically methylates the guanine in position
NtRootA4_32670	COG1473	amidohydrolase
NtRootA4_32680	COG0477	Major facilitator Superfamily
NtRootA4_32690	COG2807	transmembrane transport
NtRootA4_32720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NtRootA4_32830	COG2188	Transcriptional regulator
NtRootA4_32900	COG1012	belongs to the aldehyde dehydrogenase family
NtRootA4_32930	COG0596	Alpha beta hydrolase
NtRootA4_32930	COG2945	thiolester hydrolase activity
NtRootA4_32940	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_33010	COG1846	Transcriptional regulator
NtRootA4_33020	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
NtRootA4_33030	COG0789	Transcriptional regulator
NtRootA4_33040	COG0484	heat shock protein binding
NtRootA4_33050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NtRootA4_33060	COG0443	Heat shock 70 kDa protein
NtRootA4_33070	COG3739	integral membrane protein
NtRootA4_33120	COG4977	sequence-specific DNA binding
NtRootA4_33120	COG1917	Cupin 2, conserved barrel domain protein
NtRootA4_33150	COG3540	Alkaline phosphatase
NtRootA4_33160	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
NtRootA4_33230	COG0531	amino acid
NtRootA4_33260	COG3226	Transcriptional regulator
NtRootA4_33270	COG1280	lysine exporter protein (LysE YggA)
NtRootA4_33320	COG0492	ferredoxin-NADP+ reductase activity
NtRootA4_33330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NtRootA4_33340	COG0798	PFAM Bile acid sodium symporter
NtRootA4_33350	COG0640	Transcriptional regulator
NtRootA4_33370	COG2409	Drug exporters of the RND superfamily
NtRootA4_33400	COG3795	YCII-related domain
NtRootA4_33410	COG4941	Belongs to the sigma-70 factor family
NtRootA4_33460	COG1280	lysine exporter protein (LysE YggA)
NtRootA4_33480	COG1609	Transcriptional regulator
NtRootA4_33490	COG1957	nucleoside hydrolase
NtRootA4_33500	COG0477	Major facilitator Superfamily
NtRootA4_33510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NtRootA4_33540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NtRootA4_33560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NtRootA4_33580	COG0833	amino acid
NtRootA4_33590	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NtRootA4_33610	COG2986	histidine ammonia-lyase
NtRootA4_33670	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NtRootA4_33690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NtRootA4_33700	COG1132	(ABC) transporter
NtRootA4_33700	COG2375	cellular response to nickel ion
NtRootA4_33740	COG1122	ATPase activity
NtRootA4_33750	COG4721	ABC-type cobalt transport system, permease component
NtRootA4_33780	COG1320	monovalent cation:proton antiporter activity
NtRootA4_33790	COG2212	antiporter activity
NtRootA4_33810	COG0651	ATP synthesis coupled electron transport
NtRootA4_33820	COG1006	Multisubunit Na H antiporter MnhC subunit
NtRootA4_33830	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NtRootA4_33830	COG2111	Na H antiporter
NtRootA4_33860	COG0475	glutathione-regulated potassium exporter activity
NtRootA4_33880	COG0717	Belongs to the dCTP deaminase family
NtRootA4_33910	COG1876	peptidase activity
NtRootA4_33930	COG0686	Belongs to the AlaDH PNT family
NtRootA4_33950	COG0583	DNA-binding transcription factor activity
NtRootA4_33970	COG0640	Transcriptional regulator
NtRootA4_34010	COG0657	acetylesterase activity
NtRootA4_34010	COG2755	lipolytic protein G-D-S-L family
NtRootA4_34020	COG1609	Transcriptional regulator
NtRootA4_34030	COG0673	inositol 2-dehydrogenase activity
NtRootA4_34090	COG2115	Belongs to the xylose isomerase family
NtRootA4_34100	COG1070	Carbohydrate kinase
NtRootA4_34110	COG1609	Transcriptional regulator
NtRootA4_34140	COG2160	L-arabinose isomerase activity
NtRootA4_34150	COG2017	converts alpha-aldose to the beta-anomer
NtRootA4_34170	COG2211	Major facilitator Superfamily
NtRootA4_34180	COG1940	carbohydrate kinase activity
NtRootA4_34180	COG1846	Transcriptional regulator
NtRootA4_34200	COG0765	amino acid transport
NtRootA4_34210	COG0765	amino acid transport
NtRootA4_34240	COG0251	oxidation-reduction process
NtRootA4_34270	COG0583	DNA-binding transcription factor activity
NtRootA4_34300	COG1609	Transcriptional regulator
NtRootA4_34310	COG3254	rhamnose metabolic process
NtRootA4_34330	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_34330	COG3347	Dehydrogenase
NtRootA4_34340	COG1070	Carbohydrate kinase
NtRootA4_34350	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NtRootA4_34370	COG3387	PFAM Glycoside hydrolase 15-related
NtRootA4_34380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA4_34390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootA4_34400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NtRootA4_34440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA4_34450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA4_34470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootA4_34490	COG1126	abc transporter atp-binding protein
NtRootA4_34500	COG0765	amino acid transport
NtRootA4_34530	COG0433	COG0433 Predicted ATPase
NtRootA4_34560	COG3336	cytochrome c oxidase
NtRootA4_34570	COG0776	regulation of translation
NtRootA4_34620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NtRootA4_34630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NtRootA4_34640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NtRootA4_34650	COG1017	nitric oxide dioxygenase activity
NtRootA4_34650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NtRootA4_34740	COG1120	ATPase activity
NtRootA4_34750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootA4_34760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootA4_34840	COG3012	SEC-C Motif Domain Protein
NtRootA4_34870	COG0667	Aldo Keto reductase
NtRootA4_34950	COG2186	Transcriptional regulator
NtRootA4_34970	COG1027	Aspartate ammonia-lyase
NtRootA4_35020	COG3254	rhamnose metabolic process
NtRootA4_35040	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootA4_35060	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_35080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NtRootA4_35110	COG4221	oxidoreductase activity
NtRootA4_35130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NtRootA4_35140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NtRootA4_35180	COG1522	sequence-specific DNA binding
NtRootA4_35190	COG1280	lysine exporter protein (LysE YggA)
NtRootA4_35210	COG0640	Transcriptional regulator
NtRootA4_35250	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA4_35270	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA4_35280	COG1414	Transcriptional regulator
NtRootA4_35300	COG0477	Major facilitator Superfamily
NtRootA4_35320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NtRootA4_35370	COG1760	l-serine dehydratase
NtRootA4_35420	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA4_35440	COG0281	malic enzyme
NtRootA4_35450	COG1309	transcriptional regulator
NtRootA4_35490	COG2211	Major facilitator Superfamily
NtRootA4_35500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NtRootA4_35510	COG0477	Major facilitator Superfamily
NtRootA4_35520	COG0477	Major facilitator Superfamily
NtRootA4_35530	COG2814	Major facilitator Superfamily
NtRootA4_35600	COG1113	amino acid transport
NtRootA4_35610	COG0246	Mannitol dehydrogenase
NtRootA4_35620	COG2213	PTS system mannitol-specific
NtRootA4_35620	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NtRootA4_35640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NtRootA4_35680	COG0596	Alpha beta hydrolase
NtRootA4_35700	COG1793	dna ligase
NtRootA4_35740	COG0686	Belongs to the AlaDH PNT family
NtRootA4_35780	COG0673	inositol 2-dehydrogenase activity
NtRootA4_35830	COG1309	transcriptional regulator
NtRootA4_35840	COG0431	NADPH-dependent FMN reductase
NtRootA4_35890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NtRootA4_35930	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootA4_35940	COG0022	dehydrogenase e1 component
NtRootA4_35960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NtRootA4_35970	COG1950	PFAM Membrane protein of
NtRootA4_36000	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NtRootA4_36030	COG1607	acyl-coa hydrolase
NtRootA4_36040	COG4221	oxidoreductase activity
NtRootA4_36050	COG0477	Major facilitator Superfamily
NtRootA4_36060	COG1984	allophanate hydrolase subunit 2
NtRootA4_36070	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NtRootA4_36080	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NtRootA4_36090	COG0583	DNA-binding transcription factor activity
NtRootA4_36110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NtRootA4_36120	COG0436	Aminotransferase
NtRootA4_36170	COG3971	2-oxopent-4-enoate hydratase activity
NtRootA4_36200	COG1802	Transcriptional regulator
NtRootA4_36210	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA4_36270	COG2207	Transcriptional regulator
NtRootA4_36270	COG3708	Transcriptional regulator
NtRootA4_36280	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_36440	COG2205	protein histidine kinase activity
NtRootA4_36450	COG0515	serine threonine protein kinase
NtRootA4_36450	COG2815	serine threonine protein kinase
NtRootA4_36490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NtRootA4_36500	COG3387	PFAM Glycoside hydrolase 15-related
NtRootA4_36520	COG0076	glutamate decarboxylase activity
NtRootA4_36540	COG1011	Hydrolase
NtRootA4_36580	COG1414	Transcriptional regulator
NtRootA4_36590	COG2814	Major facilitator Superfamily
NtRootA4_36680	COG1846	Transcriptional regulator
NtRootA4_36740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NtRootA4_36750	COG1760	l-serine dehydratase
NtRootA4_36760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NtRootA4_36770	COG0509	glycine decarboxylation via glycine cleavage system
NtRootA4_36780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NtRootA4_36790	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NtRootA4_36790	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NtRootA4_36810	COG2271	Major facilitator Superfamily
NtRootA4_36830	COG1970	mechanosensitive ion channel activity
NtRootA4_37140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NtRootA4_37160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NtRootA4_37210	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA4_37220	COG2814	Major facilitator Superfamily
NtRootA4_37240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NtRootA4_37270	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA4_37280	COG0251	oxidation-reduction process
NtRootA4_37300	COG1414	Transcriptional regulator
NtRootA4_37310	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NtRootA4_37330	COG0183	Belongs to the thiolase family
NtRootA4_37340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NtRootA4_37350	COG2267	carboxylic ester hydrolase activity
NtRootA4_37380	COG3485	protocatechuate 3,4-dioxygenase
NtRootA4_37390	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NtRootA4_37390	COG1082	Xylose isomerase domain protein TIM barrel
NtRootA4_37400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NtRootA4_37410	COG1414	Transcriptional regulator
NtRootA4_37450	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NtRootA4_37470	COG3706	GGDEF domain
NtRootA4_37530	COG0583	DNA-binding transcription factor activity
NtRootA4_37600	COG2610	gluconate transmembrane transporter activity
NtRootA4_37610	COG0800	Aldolase
NtRootA4_37620	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
NtRootA4_37650	COG1414	Transcriptional regulator
NtRootA4_37750	COG2326	polyphosphate kinase activity
NtRootA4_37770	COG1737	Transcriptional regulator
NtRootA4_37780	COG3876	Protein conserved in bacteria
NtRootA4_37790	COG1472	Belongs to the glycosyl hydrolase 3 family
NtRootA4_37830	COG1937	Protein conserved in bacteria
NtRootA4_37840	COG2217	Heavy metal translocating P-type atpase
NtRootA4_37950	COG0534	Mate efflux family protein
NtRootA4_37970	COG2259	Doxx family
NtRootA4_38000	COG3848	Pyruvate phosphate dikinase
NtRootA4_38000	COG0574	Belongs to the PEP-utilizing enzyme family
NtRootA4_38020	COG1607	acyl-coa hydrolase
NtRootA4_38050	COG3958	Transketolase
NtRootA4_38060	COG3959	Transketolase, thiamine diphosphate binding domain
NtRootA4_38090	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootA4_38100	COG2376	Dihydroxyacetone kinase
NtRootA4_38110	COG0698	ribose 5-phosphate isomerase
NtRootA4_38140	COG0305	Participates in initiation and elongation during chromosome replication
NtRootA4_38220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NtRootA4_38230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NtRootA4_38300	COG1131	(ABC) transporter
NtRootA4_38320	COG0384	phenazine biosynthesis protein PhzF
NtRootA4_38340	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA4_38350	COG0359	binds to the 23S rRNA
NtRootA4_38360	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NtRootA4_38380	COG0360	Binds together with S18 to 16S ribosomal RNA
NtRootA4_38410	COG1113	amino acid transport
NtRootA4_38420	COG1362	aminopeptidase activity
NtRootA4_38490	COG0833	amino acid
NtRootA4_38500	COG2197	response regulator
NtRootA4_38510	COG4585	Histidine kinase
NtRootA4_38530	COG1131	(ABC) transporter
NtRootA4_38540	COG1597	lipid kinase activity
NtRootA4_38560	COG0738	Major facilitator superfamily
NtRootA4_38600	COG0768	penicillin binding
NtRootA4_38610	COG1501	Belongs to the glycosyl hydrolase 31 family
NtRootA4_38620	COG2197	response regulator
NtRootA4_38630	COG4585	Histidine kinase
NtRootA4_38650	COG1136	(ABC) transporter
NtRootA4_38660	COG1733	regulation of RNA biosynthetic process
NtRootA4_38670	COG2910	NAD(P)H-binding
NtRootA4_38710	COG0406	alpha-ribazole phosphatase activity
NtRootA4_38720	COG0617	tRNA 3'-terminal CCA addition
NtRootA4_38760	COG0492	ferredoxin-NADP+ reductase activity
NtRootA4_38770	COG3118	belongs to the thioredoxin family
NtRootA4_38810	COG1192	Involved in chromosome partitioning
NtRootA4_38820	COG0357	Ribosomal RNA small subunit methyltransferase G
NtRootA4_38840	COG0706	membrane insertase activity
NtRootA4_38850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NtRootA4_38860	COG0594	ribonuclease P activity
NtRootA4_38870	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NtRootA4_38880	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NtRootA4_38890	COG0592	DNA-directed DNA polymerase activity
NtRootA4_38900	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NtRootA4_38910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NtRootA4_38920	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
NtRootA4_38930	COG0187	DNA topoisomerase II activity
NtRootA4_38940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NtRootA4_38960	COG3266	domain, Protein
NtRootA4_38980	COG1215	transferase activity, transferring glycosyl groups
NtRootA4_39010	COG0457	Tetratricopeptide repeat
NtRootA4_39010	COG0705	Rhomboid family
NtRootA4_39030	COG2818	Glycosylase
NtRootA4_39050	COG2169	Transcriptional regulator
NtRootA4_39050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NtRootA4_39060	COG1595	DNA-templated transcription, initiation
NtRootA4_39090	COG3764	Sortase (surface protein transpeptidase)
NtRootA4_39110	COG0515	serine threonine protein kinase
NtRootA4_39120	COG0515	serine threonine protein kinase
NtRootA4_39130	COG0768	penicillin binding
NtRootA4_39160	COG1716	ATPase activity
NtRootA4_39170	COG1716	ATPase activity
NtRootA4_39260	COG1960	acyl-CoA dehydrogenase activity
NtRootA4_39290	COG0477	Major facilitator Superfamily
NtRootA4_39300	COG2175	clavaminate synthase activity
NtRootA4_39370	COG0346	lactoylglutathione lyase activity
NtRootA4_39410	COG2186	Transcriptional regulator
NtRootA4_39420	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NtRootA4_39430	COG0477	Major facilitator Superfamily
NtRootA4_39440	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NtRootA4_39450	COG4770	biotin carboxylase activity
NtRootA4_39460	COG1940	carbohydrate kinase activity
NtRootA4_39470	COG1653	transport
NtRootA4_39500	COG0395	ABC-type sugar transport system, permease component
NtRootA4_39520	COG1940	carbohydrate kinase activity
NtRootA4_39530	COG3119	arylsulfatase activity
NtRootA4_39550	COG3142	Participates in the control of copper homeostasis
NtRootA4_39560	COG0277	FAD linked oxidase domain protein
NtRootA4_39580	COG1733	regulation of RNA biosynthetic process
NtRootA4_39600	COG0385	Bile acid
NtRootA4_39610	COG0659	secondary active sulfate transmembrane transporter activity
NtRootA4_39650	COG0435	Glutathione S-transferase
NtRootA4_39660	COG0561	phosphatase activity
NtRootA4_39700	COG0584	glycerophosphoryl diester phosphodiesterase
NtRootA4_39710	COG3250	beta-galactosidase activity
NtRootA4_39720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootA4_39730	COG1929	Belongs to the glycerate kinase type-1 family
NtRootA4_39830	COG2720	vancomycin resistance protein
NtRootA4_39860	COG2135	peptidase activity
NtRootA4_39890	COG0693	protein deglycase activity
NtRootA4_39910	COG1131	(ABC) transporter
NtRootA4_39930	COG2197	response regulator
NtRootA4_39940	COG4585	Histidine kinase
NtRootA4_39970	COG2233	PERMEase
NtRootA4_39990	COG0778	Nitroreductase
NtRootA4_40030	COG3104	oligopeptide transport
NtRootA4_40050	COG3340	Belongs to the peptidase S51 family
NtRootA4_40060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NtRootA4_40060	COG0425	Belongs to the sulfur carrier protein TusA family
NtRootA4_40090	COG1597	lipid kinase activity
NtRootA4_40100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NtRootA4_40120	COG3973	AAA domain
NtRootA4_40130	COG0561	phosphatase activity
NtRootA4_40150	COG1191	sigma factor activity
NtRootA4_40290	COG0037	tRNA processing
NtRootA4_40320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NtRootA4_40330	COG0302	gtp cyclohydrolase
NtRootA4_40350	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NtRootA4_40410	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NtRootA4_40430	COG2814	Major facilitator Superfamily
NtRootA4_40480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NtRootA4_40530	COG0823	Involved in the tonB-independent uptake of proteins
NtRootA4_40530	COG1506	peptidase
NtRootA4_40540	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NtRootA4_40570	COG2376	Dihydroxyacetone kinase
NtRootA4_40590	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
NtRootA4_40650	COG3707	response regulator
NtRootA4_40670	COG1301	dicarboxylic acid transport
NtRootA4_40710	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NtRootA4_40740	COG0671	phosphoesterase, PA-phosphatase related
NtRootA4_40790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NtRootA4_40910	COG1609	Transcriptional regulator
NtRootA4_40950	COG0831	urea catabolic process
NtRootA4_40960	COG0832	Belongs to the urease beta subunit family
NtRootA4_40970	COG0804	urea catabolic process
NtRootA4_40980	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NtRootA4_40990	COG0830	nickel cation binding
NtRootA4_41000	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NtRootA4_41010	COG0829	nickel cation binding
NtRootA4_41020	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
NtRootA4_41120	COG0656	L-ascorbic acid biosynthetic process
NtRootA4_41130	COG1475	DNA binding
NtRootA4_41250	COG2720	vancomycin resistance protein
NtRootA4_41320	COG4124	Belongs to the glycosyl hydrolase 26 family
NtRootA4_41370	COG1129	ABC transporter
NtRootA4_41380	COG1172	Belongs to the binding-protein-dependent transport system permease family
NtRootA4_41410	COG2826	transposase and inactivated derivatives, IS30 family
NtRootA4_41460	COG0673	inositol 2-dehydrogenase activity
NtRootA4_41500	COG1929	Belongs to the glycerate kinase type-1 family
NtRootA4_41520	COG1204	response to ionizing radiation
NtRootA4_41580	COG4974	Belongs to the 'phage' integrase family
NtRootA4_41680	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootA4_41710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NtRootA4_41810	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NtRootA4_41810	COG3608	succinylglutamate desuccinylase aspartoacylase
NtRootA4_42030	COG2801	Transposase and inactivated derivatives
NtRootA4_42030	COG3415	Transposase
NtRootA4_42160	COG2211	Major facilitator Superfamily
NtRootA4_42580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NtRootA4_42640	COG1793	dna ligase
NtRootA4_42670	COG2267	carboxylic ester hydrolase activity
NtRootA4_42690	COG0657	acetylesterase activity
NtRootA4_42700	COG2814	Major facilitator Superfamily
NtRootA4_42710	COG1609	Transcriptional regulator