locus-tag	class	description
NtRootC45_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NtRootC45_00020	COG0592	DNA-directed DNA polymerase activity
NtRootC45_00030	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NtRootC45_00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NtRootC45_00050	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
NtRootC45_00060	COG0187	DNA topoisomerase II activity
NtRootC45_00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NtRootC45_00090	COG3266	domain, Protein
NtRootC45_00110	COG1215	transferase activity, transferring glycosyl groups
NtRootC45_00140	COG0457	Tetratricopeptide repeat
NtRootC45_00140	COG0705	Rhomboid family
NtRootC45_00160	COG2818	Glycosylase
NtRootC45_00180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NtRootC45_00180	COG2169	Transcriptional regulator
NtRootC45_00190	COG1595	DNA-templated transcription, initiation
NtRootC45_00220	COG3764	Sortase (surface protein transpeptidase)
NtRootC45_00240	COG0515	serine threonine protein kinase
NtRootC45_00250	COG0515	serine threonine protein kinase
NtRootC45_00260	COG0768	penicillin binding
NtRootC45_00290	COG1716	ATPase activity
NtRootC45_00300	COG1716	ATPase activity
NtRootC45_00390	COG1960	acyl-CoA dehydrogenase activity
NtRootC45_00420	COG0477	Major facilitator Superfamily
NtRootC45_00430	COG2175	clavaminate synthase activity
NtRootC45_00500	COG0346	lactoylglutathione lyase activity
NtRootC45_00530	COG2186	Transcriptional regulator
NtRootC45_00540	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NtRootC45_00550	COG0477	Major facilitator Superfamily
NtRootC45_00560	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NtRootC45_00570	COG4770	biotin carboxylase activity
NtRootC45_00580	COG1940	carbohydrate kinase activity
NtRootC45_00590	COG1653	transport
NtRootC45_00620	COG0395	ABC-type sugar transport system, permease component
NtRootC45_00640	COG1940	carbohydrate kinase activity
NtRootC45_00650	COG3119	arylsulfatase activity
NtRootC45_00670	COG3142	Participates in the control of copper homeostasis
NtRootC45_00680	COG0277	FAD linked oxidase domain protein
NtRootC45_00700	COG1733	regulation of RNA biosynthetic process
NtRootC45_00720	COG0385	Bile acid
NtRootC45_00730	COG0659	secondary active sulfate transmembrane transporter activity
NtRootC45_00770	COG0435	Glutathione S-transferase
NtRootC45_00780	COG0561	phosphatase activity
NtRootC45_00820	COG0584	glycerophosphoryl diester phosphodiesterase
NtRootC45_00830	COG3250	beta-galactosidase activity
NtRootC45_00840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootC45_00850	COG1929	Belongs to the glycerate kinase type-1 family
NtRootC45_00950	COG2720	vancomycin resistance protein
NtRootC45_00980	COG2135	peptidase activity
NtRootC45_01010	COG0693	protein deglycase activity
NtRootC45_01030	COG1131	(ABC) transporter
NtRootC45_01050	COG2197	response regulator
NtRootC45_01060	COG4585	Histidine kinase
NtRootC45_01090	COG2233	PERMEase
NtRootC45_01110	COG0778	Nitroreductase
NtRootC45_01150	COG3104	oligopeptide transport
NtRootC45_01170	COG3340	Belongs to the peptidase S51 family
NtRootC45_01180	COG0425	Belongs to the sulfur carrier protein TusA family
NtRootC45_01180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NtRootC45_01210	COG1597	lipid kinase activity
NtRootC45_01220	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NtRootC45_01240	COG3973	AAA domain
NtRootC45_01250	COG0561	phosphatase activity
NtRootC45_01270	COG1191	sigma factor activity
NtRootC45_01410	COG0037	tRNA processing
NtRootC45_01440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NtRootC45_01450	COG0302	gtp cyclohydrolase
NtRootC45_01470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NtRootC45_01530	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NtRootC45_01550	COG2814	Major facilitator Superfamily
NtRootC45_01600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NtRootC45_01650	COG0823	Involved in the tonB-independent uptake of proteins
NtRootC45_01650	COG1506	peptidase
NtRootC45_01660	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NtRootC45_01690	COG2376	Dihydroxyacetone kinase
NtRootC45_01710	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
NtRootC45_01770	COG3707	response regulator
NtRootC45_01790	COG1301	dicarboxylic acid transport
NtRootC45_01830	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NtRootC45_01860	COG0671	phosphoesterase, PA-phosphatase related
NtRootC45_01910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NtRootC45_02030	COG1609	Transcriptional regulator
NtRootC45_02070	COG0831	urea catabolic process
NtRootC45_02080	COG0832	Belongs to the urease beta subunit family
NtRootC45_02090	COG0804	urea catabolic process
NtRootC45_02100	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NtRootC45_02110	COG0830	nickel cation binding
NtRootC45_02120	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NtRootC45_02130	COG0829	nickel cation binding
NtRootC45_02140	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
NtRootC45_02240	COG0656	L-ascorbic acid biosynthetic process
NtRootC45_02260	COG0667	Aldo Keto reductase
NtRootC45_02270	COG0656	L-ascorbic acid biosynthetic process
NtRootC45_02290	COG2826	transposase and inactivated derivatives, IS30 family
NtRootC45_02300	COG3360	Dodecin
NtRootC45_02310	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_02340	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NtRootC45_02350	COG0028	Belongs to the TPP enzyme family
NtRootC45_02360	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NtRootC45_02370	COG1233	COG1233 Phytoene dehydrogenase and related
NtRootC45_02380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NtRootC45_02400	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_02430	COG2186	Transcriptional regulator
NtRootC45_02460	COG2084	Dehydrogenase
NtRootC45_02470	COG2610	gluconate transmembrane transporter activity
NtRootC45_02580	COG0076	glutamate decarboxylase activity
NtRootC45_02590	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NtRootC45_02680	COG1216	Glycosyl transferase, family 2
NtRootC45_02700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NtRootC45_02710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NtRootC45_02790	COG0346	lactoylglutathione lyase activity
NtRootC45_02810	COG0697	spore germination
NtRootC45_02820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NtRootC45_02830	COG2186	Transcriptional regulator
NtRootC45_02840	COG1653	transport
NtRootC45_02850	COG1175	transmembrane transport
NtRootC45_02870	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootC45_02900	COG0477	Major facilitator Superfamily
NtRootC45_02910	COG2890	protein-(glutamine-N5) methyltransferase activity
NtRootC45_02950	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NtRootC45_02960	COG0395	ABC-type sugar transport system, permease component
NtRootC45_02970	COG1175	transmembrane transport
NtRootC45_03080	COG3226	Transcriptional regulator
NtRootC45_03100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NtRootC45_03100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NtRootC45_03100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NtRootC45_03110	COG1105	Belongs to the carbohydrate kinase PfkB family
NtRootC45_03120	COG1349	DNA-binding transcription factor activity
NtRootC45_03170	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NtRootC45_03220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NtRootC45_03290	COG1846	Transcriptional regulator
NtRootC45_03350	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NtRootC45_03420	COG0129	dihydroxy-acid dehydratase activity
NtRootC45_03450	COG5006	permease, DMT superfamily
NtRootC45_03460	COG1609	Transcriptional regulator
NtRootC45_03470	COG0673	inositol 2-dehydrogenase activity
NtRootC45_03480	COG0673	inositol 2-dehydrogenase activity
NtRootC45_03500	COG0673	inositol 2-dehydrogenase activity
NtRootC45_03550	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NtRootC45_03560	COG1984	allophanate hydrolase subunit 2
NtRootC45_03580	COG2733	membrane
NtRootC45_03660	COG4122	O-methyltransferase activity
NtRootC45_03670	COG0454	-acetyltransferase
NtRootC45_03670	COG0456	acetyltransferase
NtRootC45_03700	COG1132	(ABC) transporter
NtRootC45_03720	COG2207	Transcriptional regulator
NtRootC45_03760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootC45_03770	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootC45_03780	COG1120	ATPase activity
NtRootC45_03790	COG2826	transposase and inactivated derivatives, IS30 family
NtRootC45_03820	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_03830	COG2826	transposase and inactivated derivatives, IS30 family
NtRootC45_03890	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NtRootC45_03930	COG2826	transposase and inactivated derivatives, IS30 family
NtRootC45_03950	COG0010	Belongs to the arginase family
NtRootC45_03960	COG2252	PERMEase
NtRootC45_04020	COG0574	Belongs to the PEP-utilizing enzyme family
NtRootC45_04020	COG3848	Pyruvate phosphate dikinase
NtRootC45_04050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NtRootC45_04230	COG0640	Transcriptional regulator
NtRootC45_04260	COG2182	Extracellular solute-binding protein
NtRootC45_04300	COG1609	Transcriptional regulator
NtRootC45_04340	COG2197	response regulator
NtRootC45_04350	COG4585	Histidine kinase
NtRootC45_04370	COG0666	response to abiotic stimulus
NtRootC45_04380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NtRootC45_04400	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NtRootC45_04470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NtRootC45_04490	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NtRootC45_04500	COG0303	'Molybdopterin
NtRootC45_04510	COG1063	alcohol dehydrogenase
NtRootC45_04530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NtRootC45_04540	COG3404	Formiminotransferase-cyclodeaminase
NtRootC45_04570	COG1802	Transcriptional regulator
NtRootC45_04580	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NtRootC45_04600	COG0583	DNA-binding transcription factor activity
NtRootC45_04630	COG2197	response regulator
NtRootC45_04680	COG0415	Belongs to the DNA photolyase family
NtRootC45_04710	COG1024	Enoyl-CoA hydratase
NtRootC45_04770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NtRootC45_04810	COG1012	belongs to the aldehyde dehydrogenase family
NtRootC45_04850	COG0789	Transcriptional regulator
NtRootC45_04860	COG1695	Transcriptional regulator
NtRootC45_04890	COG1609	Transcriptional regulator
NtRootC45_04910	COG1175	transmembrane transport
NtRootC45_04920	COG0395	ABC-type sugar transport system, permease component
NtRootC45_04940	COG0673	inositol 2-dehydrogenase activity
NtRootC45_04960	COG1904	glucuronate isomerase
NtRootC45_04970	COG0246	Mannitol dehydrogenase
NtRootC45_04980	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootC45_04990	COG3265	gluconokinase activity
NtRootC45_05000	COG4213	ABC transporter substrate-binding protein
NtRootC45_05010	COG1129	ABC transporter
NtRootC45_05020	COG4214	carbohydrate transport
NtRootC45_05030	COG1609	Transcriptional regulator
NtRootC45_05040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NtRootC45_05100	COG2826	transposase and inactivated derivatives, IS30 family
NtRootC45_05120	COG2826	transposase and inactivated derivatives, IS30 family
NtRootC45_05150	COG1120	ATPase activity
NtRootC45_05160	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootC45_05170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootC45_05180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NtRootC45_05250	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NtRootC45_05260	COG2205	protein histidine kinase activity
NtRootC45_05280	COG1309	transcriptional regulator
NtRootC45_05290	COG0477	Major facilitator Superfamily
NtRootC45_05300	COG3386	PFAM SMP-30 Gluconolaconase
NtRootC45_05330	COG0488	(ABC) transporter
NtRootC45_05370	COG0477	Major facilitator Superfamily
NtRootC45_05380	COG3263	regulation of cellular component size
NtRootC45_05390	COG4932	domain protein
NtRootC45_05390	COG5492	domain, Protein
NtRootC45_05440	COG1609	Transcriptional regulator
NtRootC45_05460	COG0765	amino acid transport
NtRootC45_05470	COG1126	abc transporter atp-binding protein
NtRootC45_05480	COG0673	inositol 2-dehydrogenase activity
NtRootC45_05580	COG1832	CoA-binding protein
NtRootC45_05610	COG2315	Protein conserved in bacteria
NtRootC45_05620	COG1653	transport
NtRootC45_05630	COG1175	transmembrane transport
NtRootC45_05640	COG0395	ABC-type sugar transport system, permease component
NtRootC45_05710	COG2368	4-hydroxyphenylacetate
NtRootC45_05790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NtRootC45_05800	COG3706	GGDEF domain
NtRootC45_05830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NtRootC45_05840	COG0047	phosphoribosylformylglycinamidine synthase activity
NtRootC45_05880	COG3546	catalase activity
NtRootC45_05890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootC45_05950	COG1846	Transcriptional regulator
NtRootC45_05970	COG2826	transposase and inactivated derivatives, IS30 family
NtRootC45_05990	COG5416	Lipopolysaccharide assembly protein A domain
NtRootC45_06060	COG2847	Copper chaperone PCu(A)C
NtRootC45_06070	COG2837	iron assimilation
NtRootC45_06120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NtRootC45_06140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NtRootC45_06140	COG3323	Protein of unknown function (DUF1653)
NtRootC45_06160	COG1012	belongs to the aldehyde dehydrogenase family
NtRootC45_06190	COG1846	Transcriptional regulator
NtRootC45_06250	COG0739	heme binding
NtRootC45_06250	COG0741	lytic transglycosylase activity
NtRootC45_06250	COG1196	nuclear chromosome segregation
NtRootC45_06260	COG0386	Belongs to the glutathione peroxidase family
NtRootC45_06270	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NtRootC45_06330	COG1609	Transcriptional regulator
NtRootC45_06350	COG1175	transmembrane transport
NtRootC45_06360	COG0395	ABC-type sugar transport system, permease component
NtRootC45_06390	COG0438	transferase activity, transferring glycosyl groups
NtRootC45_06440	COG1621	beta-fructofuranosidase activity
NtRootC45_06450	COG1609	Transcriptional regulator
NtRootC45_06460	COG0395	ABC-type sugar transport system, permease component
NtRootC45_06500	COG0589	response to stress
NtRootC45_06540	COG3290	protein histidine kinase activity
NtRootC45_06550	COG4565	transcriptional regulatory protein
NtRootC45_06560	COG4702	Belongs to the UPF0303 family
NtRootC45_06580	COG0823	Involved in the tonB-independent uptake of proteins
NtRootC45_06600	COG0673	inositol 2-dehydrogenase activity
NtRootC45_06610	COG0673	inositol 2-dehydrogenase activity
NtRootC45_06630	COG0395	ABC-type sugar transport system, permease component
NtRootC45_06700	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NtRootC45_06720	COG1476	TRANSCRIPTIONal
NtRootC45_06770	COG1309	transcriptional regulator
NtRootC45_06790	COG0351	phosphomethylpyrimidine kinase
NtRootC45_06810	COG0642	Histidine kinase
NtRootC45_06820	COG0745	RESPONSE REGULATOR receiver
NtRootC45_06830	COG0477	Major facilitator Superfamily
NtRootC45_06890	COG0343	queuine tRNA-ribosyltransferase activity
NtRootC45_06970	COG1960	acyl-CoA dehydrogenase activity
NtRootC45_07030	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NtRootC45_07050	COG0586	Pfam SNARE associated Golgi protein
NtRootC45_07070	COG0564	pseudouridine synthase activity
NtRootC45_07120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NtRootC45_07130	COG2364	Membrane
NtRootC45_07160	COG1215	transferase activity, transferring glycosyl groups
NtRootC45_07180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NtRootC45_07190	COG1201	RNA secondary structure unwinding
NtRootC45_07240	COG0475	glutathione-regulated potassium exporter activity
NtRootC45_07240	COG0569	domain protein
NtRootC45_07290	COG0438	transferase activity, transferring glycosyl groups
NtRootC45_07330	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NtRootC45_07410	COG2205	protein histidine kinase activity
NtRootC45_07420	COG0745	RESPONSE REGULATOR receiver
NtRootC45_07440	COG2062	phosphohistidine phosphatase, SixA
NtRootC45_07450	COG0583	DNA-binding transcription factor activity
NtRootC45_07460	COG0697	spore germination
NtRootC45_07480	COG1309	transcriptional regulator
NtRootC45_07490	COG1511	domain protein
NtRootC45_07530	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
NtRootC45_07540	COG1940	carbohydrate kinase activity
NtRootC45_07560	COG4608	Belongs to the ABC transporter superfamily
NtRootC45_07570	COG0444	Belongs to the ABC transporter superfamily
NtRootC45_07580	COG0601	transmembrane transport
NtRootC45_07590	COG0747	negative chemotaxis
NtRootC45_07610	COG1309	transcriptional regulator
NtRootC45_07620	COG0477	Major facilitator Superfamily
NtRootC45_07630	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NtRootC45_07640	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootC45_07650	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
NtRootC45_07660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NtRootC45_07660	COG1017	nitric oxide dioxygenase activity
NtRootC45_07710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NtRootC45_07720	COG0514	ATP-dependent DNA helicase (RecQ)
NtRootC45_07740	COG0477	Major facilitator Superfamily
NtRootC45_07750	COG1505	serine-type exopeptidase activity
NtRootC45_07770	COG1113	amino acid transport
NtRootC45_07810	COG0604	alcohol dehydrogenase
NtRootC45_07810	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_07810	COG3321	synthase
NtRootC45_07830	COG1966	Carbon starvation protein
NtRootC45_07870	COG0656	L-ascorbic acid biosynthetic process
NtRootC45_07910	COG0673	inositol 2-dehydrogenase activity
NtRootC45_07920	COG1172	Belongs to the binding-protein-dependent transport system permease family
NtRootC45_07960	COG1609	Transcriptional regulator
NtRootC45_07990	COG0154	amidase activity
NtRootC45_08030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NtRootC45_08090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NtRootC45_08100	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NtRootC45_08140	COG0588	phosphoglycerate mutase activity
NtRootC45_08200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NtRootC45_08210	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NtRootC45_08230	COG0215	cysteine-tRNA ligase activity
NtRootC45_08310	COG0366	Alpha amylase catalytic
NtRootC45_08330	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NtRootC45_08360	COG1609	Transcriptional regulator
NtRootC45_08370	COG0366	Alpha amylase catalytic
NtRootC45_08400	COG3833	ABC-type maltose transport systems, permease component
NtRootC45_08410	COG0366	Alpha amylase catalytic
NtRootC45_08420	COG0277	FAD linked oxidase domain protein
NtRootC45_08450	COG0402	S-adenosylhomocysteine deaminase activity
NtRootC45_08460	COG4608	Belongs to the ABC transporter superfamily
NtRootC45_08470	COG0444	Belongs to the ABC transporter superfamily
NtRootC45_08480	COG0601	transmembrane transport
NtRootC45_08500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootC45_08510	COG0402	S-adenosylhomocysteine deaminase activity
NtRootC45_08550	COG3842	ATPase activity
NtRootC45_08650	COG0542	response to heat
NtRootC45_08660	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_08670	COG1609	Transcriptional regulator
NtRootC45_08680	COG0395	ABC-type sugar transport system, permease component
NtRootC45_08690	COG1175	transmembrane transport
NtRootC45_08700	COG1653	transport
NtRootC45_08720	COG1621	beta-fructofuranosidase activity
NtRootC45_08780	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NtRootC45_08800	COG3634	alkyl hydroperoxide reductase activity
NtRootC45_08850	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_08870	COG1960	acyl-CoA dehydrogenase activity
NtRootC45_08920	COG0579	oxidoreductase
NtRootC45_08970	COG2957	Belongs to the agmatine deiminase family
NtRootC45_08990	COG0024	Methionine aminopeptidase
NtRootC45_09020	COG0492	ferredoxin-NADP+ reductase activity
NtRootC45_09060	COG0477	Major facilitator Superfamily
NtRootC45_09080	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NtRootC45_09080	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NtRootC45_09090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NtRootC45_09100	COG0509	glycine decarboxylation via glycine cleavage system
NtRootC45_09110	COG1760	l-serine dehydratase
NtRootC45_09120	COG1864	DNA RNA non-specific endonuclease
NtRootC45_09120	COG3591	Belongs to the peptidase S1B family
NtRootC45_09210	COG0459	protein refolding
NtRootC45_09220	COG0328	RNA-DNA hybrid ribonuclease activity
NtRootC45_09240	COG2205	protein histidine kinase activity
NtRootC45_09250	COG0745	RESPONSE REGULATOR receiver
NtRootC45_09270	COG0583	DNA-binding transcription factor activity
NtRootC45_09290	COG2132	Multicopper oxidase
NtRootC45_09340	COG1278	Cold shock
NtRootC45_09360	COG2814	Major facilitator Superfamily
NtRootC45_09370	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NtRootC45_09390	COG0739	heme binding
NtRootC45_09400	COG0791	NLP P60 protein
NtRootC45_09400	COG3103	Sh3 type 3 domain protein
NtRootC45_09400	COG1388	LysM domain
NtRootC45_09430	COG0746	molybdenum cofactor guanylyltransferase activity
NtRootC45_09460	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NtRootC45_09500	COG1126	abc transporter atp-binding protein
NtRootC45_09510	COG0765	amino acid transport
NtRootC45_09520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootC45_09550	COG0488	(ABC) transporter
NtRootC45_09560	COG1132	(ABC) transporter
NtRootC45_09570	COG0494	nUDIX hydrolase
NtRootC45_09640	COG0483	inositol monophosphate 1-phosphatase activity
NtRootC45_09780	COG0045	succinate-CoA ligase (ADP-forming) activity
NtRootC45_09810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NtRootC45_09830	COG3962	Belongs to the TPP enzyme family
NtRootC45_09860	COG0673	inositol 2-dehydrogenase activity
NtRootC45_09870	COG1082	Xylose isomerase domain protein TIM barrel
NtRootC45_09880	COG3718	enzyme involved in inositol metabolism
NtRootC45_09890	COG2188	Transcriptional regulator
NtRootC45_09910	COG1172	Belongs to the binding-protein-dependent transport system permease family
NtRootC45_09960	COG0673	inositol 2-dehydrogenase activity
NtRootC45_10060	COG1396	sequence-specific DNA binding
NtRootC45_10110	COG0028	Belongs to the TPP enzyme family
NtRootC45_10120	COG0477	Major facilitator Superfamily
NtRootC45_10130	COG1234	tRNA 3'-trailer cleavage
NtRootC45_10140	COG0583	DNA-binding transcription factor activity
NtRootC45_10200	COG3142	Participates in the control of copper homeostasis
NtRootC45_10250	COG1401	restriction endodeoxyribonuclease activity
NtRootC45_10280	COG5002	protein histidine kinase activity
NtRootC45_10290	COG0745	RESPONSE REGULATOR receiver
NtRootC45_10310	COG1012	belongs to the aldehyde dehydrogenase family
NtRootC45_10340	COG1024	Enoyl-CoA hydratase
NtRootC45_10350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NtRootC45_10370	COG0477	Major facilitator Superfamily
NtRootC45_10380	COG1396	sequence-specific DNA binding
NtRootC45_10410	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NtRootC45_10430	COG3237	CsbD-like
NtRootC45_10440	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_10450	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_10490	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NtRootC45_10510	COG1902	pentaerythritol trinitrate reductase activity
NtRootC45_10540	COG2376	Dihydroxyacetone kinase
NtRootC45_10550	COG0698	ribose 5-phosphate isomerase
NtRootC45_10560	COG1250	3-hydroxyacyl-CoA dehydrogenase
NtRootC45_10570	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_10580	COG2271	Major facilitator Superfamily
NtRootC45_10590	COG0149	triose-phosphate isomerase activity
NtRootC45_10670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NtRootC45_10690	COG1254	Belongs to the acylphosphatase family
NtRootC45_10700	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
NtRootC45_10720	COG1309	transcriptional regulator
NtRootC45_10740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NtRootC45_10750	COG2186	Transcriptional regulator
NtRootC45_10760	COG0477	Major facilitator Superfamily
NtRootC45_10780	COG0640	Transcriptional regulator
NtRootC45_10800	COG4209	transmembrane transport
NtRootC45_10810	COG0395	ABC-type sugar transport system, permease component
NtRootC45_10820	COG1653	transport
NtRootC45_10920	COG1472	Belongs to the glycosyl hydrolase 3 family
NtRootC45_10930	COG0673	inositol 2-dehydrogenase activity
NtRootC45_10960	COG1609	Transcriptional regulator
NtRootC45_11000	COG0477	Major facilitator Superfamily
NtRootC45_11070	COG0640	Transcriptional regulator
NtRootC45_11100	COG1846	Transcriptional regulator
NtRootC45_11110	COG0697	spore germination
NtRootC45_11210	COG2072	flavoprotein involved in K transport
NtRootC45_11240	COG1278	Cold shock
NtRootC45_11260	COG1131	(ABC) transporter
NtRootC45_11330	COG1846	Transcriptional regulator
NtRootC45_11370	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NtRootC45_11390	COG0789	Transcriptional regulator
NtRootC45_11410	COG0484	heat shock protein binding
NtRootC45_11460	COG2271	Major facilitator Superfamily
NtRootC45_11470	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NtRootC45_11510	COG0138	bifunctional purine biosynthesis protein purh
NtRootC45_11530	COG2838	Isocitrate dehydrogenase
NtRootC45_11550	COG3639	organic phosphonate transmembrane transporter activity
NtRootC45_11560	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NtRootC45_11590	COG2188	Transcriptional regulator
NtRootC45_11620	COG0673	inositol 2-dehydrogenase activity
NtRootC45_11630	COG1136	(ABC) transporter
NtRootC45_11650	COG4213	ABC transporter substrate-binding protein
NtRootC45_11670	COG1129	ABC transporter
NtRootC45_11690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NtRootC45_11710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NtRootC45_11730	COG0531	amino acid
NtRootC45_11790	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NtRootC45_11800	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NtRootC45_11810	COG1131	(ABC) transporter
NtRootC45_11850	COG0708	Exodeoxyribonuclease III
NtRootC45_11860	COG0180	Tryptophanyl-tRNA synthetase
NtRootC45_11930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NtRootC45_11960	COG2009	succinate dehydrogenase
NtRootC45_11980	COG1473	amidohydrolase
NtRootC45_11980	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NtRootC45_11990	COG1846	Transcriptional regulator
NtRootC45_12000	COG1764	response to oxidative stress
NtRootC45_12010	COG2130	NADP-dependent
NtRootC45_12020	COG1744	ABC transporter substrate-binding protein PnrA-like
NtRootC45_12030	COG3845	ABC transporter
NtRootC45_12040	COG4603	Belongs to the binding-protein-dependent transport system permease family
NtRootC45_12050	COG1079	Belongs to the binding-protein-dependent transport system permease family
NtRootC45_12090	COG0586	Pfam SNARE associated Golgi protein
NtRootC45_12100	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NtRootC45_12110	COG3956	TIGRFAM MazG family protein
NtRootC45_12120	COG0148	phosphopyruvate hydratase activity
NtRootC45_12170	COG1252	NADH dehydrogenase
NtRootC45_12220	COG2205	protein histidine kinase activity
NtRootC45_12230	COG0745	RESPONSE REGULATOR receiver
NtRootC45_12260	COG1136	(ABC) transporter
NtRootC45_12260	COG0577	efflux transmembrane transporter activity
NtRootC45_12270	COG0577	efflux transmembrane transporter activity
NtRootC45_12270	COG1136	(ABC) transporter
NtRootC45_12330	COG0559	Belongs to the binding-protein-dependent transport system permease family
NtRootC45_12350	COG0183	Belongs to the thiolase family
NtRootC45_12360	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NtRootC45_12380	COG2017	converts alpha-aldose to the beta-anomer
NtRootC45_12400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NtRootC45_12420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NtRootC45_12440	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NtRootC45_12470	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NtRootC45_12480	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NtRootC45_12550	COG0114	fumarate hydratase activity
NtRootC45_12560	COG0288	reversible hydration of carbon dioxide
NtRootC45_12580	COG1494	fructose-1,6-bisphosphatase
NtRootC45_12600	COG1482	cell wall glycoprotein biosynthetic process
NtRootC45_12720	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NtRootC45_12730	COG1376	ErfK ybiS ycfS ynhG family protein
NtRootC45_12740	COG1357	PFAM Pentapeptide repeats (8 copies)
NtRootC45_12840	COG0714	Associated with various cellular activities
NtRootC45_12850	COG0084	hydrolase, TatD family'
NtRootC45_12860	COG3583	domain protein
NtRootC45_12870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NtRootC45_12880	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NtRootC45_12890	COG0488	(ABC) transporter
NtRootC45_12910	COG1309	transcriptional regulator
NtRootC45_12920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NtRootC45_12930	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NtRootC45_12940	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NtRootC45_12950	COG0193	aminoacyl-tRNA hydrolase activity
NtRootC45_13000	COG0822	iron-sulfur transferase activity
NtRootC45_13010	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NtRootC45_13040	COG0702	epimerase
NtRootC45_13060	COG1988	membrane-bound metal-dependent
NtRootC45_13080	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NtRootC45_13100	COG0446	pyridine nucleotide-disulphide oxidoreductase
NtRootC45_13190	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_13230	COG1609	Transcriptional regulator
NtRootC45_13240	COG2814	Major facilitator Superfamily
NtRootC45_13260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NtRootC45_13290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NtRootC45_13310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NtRootC45_13320	COG1621	beta-fructofuranosidase activity
NtRootC45_13380	COG0243	molybdopterin cofactor binding
NtRootC45_13390	COG2223	nitrite transmembrane transporter activity
NtRootC45_13400	COG0477	Major facilitator Superfamily
NtRootC45_13410	COG4770	biotin carboxylase activity
NtRootC45_13420	COG0424	maF-like protein
NtRootC45_13430	COG2409	Drug exporters of the RND superfamily
NtRootC45_13440	COG1309	transcriptional regulator
NtRootC45_13450	COG0393	Putative heavy-metal-binding
NtRootC45_13460	COG1823	symporter activity
NtRootC45_13490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NtRootC45_13500	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_13510	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NtRootC45_13510	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NtRootC45_13560	COG0714	Associated with various cellular activities
NtRootC45_13600	COG0631	protein serine/threonine phosphatase activity
NtRootC45_13640	COG1674	ftsk spoiiie
NtRootC45_13650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NtRootC45_13660	COG0483	inositol monophosphate 1-phosphatase activity
NtRootC45_13680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootC45_13720	COG4565	transcriptional regulatory protein
NtRootC45_13740	COG2851	Citrate transporter
NtRootC45_13750	COG1316	TRANSCRIPTIONal
NtRootC45_13770	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NtRootC45_13780	COG0154	amidase activity
NtRootC45_13790	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NtRootC45_13810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NtRootC45_13820	COG4209	transmembrane transport
NtRootC45_13830	COG0395	ABC-type sugar transport system, permease component
NtRootC45_13870	COG0583	DNA-binding transcription factor activity
NtRootC45_13880	COG1063	alcohol dehydrogenase
NtRootC45_13890	COG0156	8-amino-7-oxononanoate synthase activity
NtRootC45_13910	COG1228	amidohydrolase
NtRootC45_13920	COG0366	Alpha amylase catalytic
NtRootC45_13920	COG1470	cell adhesion involved in biofilm formation
NtRootC45_13930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NtRootC45_13980	COG0588	phosphoglycerate mutase activity
NtRootC45_14010	COG2873	o-acetylhomoserine
NtRootC45_14020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NtRootC45_14090	COG0423	glycine-tRNA ligase activity
NtRootC45_14130	COG0390	transport system, permease component
NtRootC45_14140	COG2205	protein histidine kinase activity
NtRootC45_14160	COG0586	Pfam SNARE associated Golgi protein
NtRootC45_14170	COG0671	phosphoesterase, PA-phosphatase related
NtRootC45_14190	COG1131	(ABC) transporter
NtRootC45_14200	COG0842	Transport permease protein
NtRootC45_14210	COG4585	Histidine kinase
NtRootC45_14220	COG2197	response regulator
NtRootC45_14250	COG0358	DNA primase activity
NtRootC45_14270	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NtRootC45_14280	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NtRootC45_14300	COG2814	Major facilitator Superfamily
NtRootC45_14340	COG0297	glycogen (starch) synthase activity
NtRootC45_14370	COG0052	Belongs to the universal ribosomal protein uS2 family
NtRootC45_14380	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NtRootC45_14390	COG0528	UMP kinase activity
NtRootC45_14400	COG0233	cytoplasmic translational termination
NtRootC45_14410	COG0575	Belongs to the CDS family
NtRootC45_14440	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NtRootC45_14460	COG3279	Response regulator of the LytR AlgR family
NtRootC45_14470	COG3275	phosphorelay sensor kinase activity
NtRootC45_14490	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NtRootC45_14500	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NtRootC45_14500	COG1796	DNA polymerase
NtRootC45_14540	COG1522	sequence-specific DNA binding
NtRootC45_14560	COG0022	dehydrogenase e1 component
NtRootC45_14570	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootC45_14580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NtRootC45_14610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NtRootC45_14630	COG1960	acyl-CoA dehydrogenase activity
NtRootC45_14680	COG0673	inositol 2-dehydrogenase activity
NtRootC45_14710	COG0673	inositol 2-dehydrogenase activity
NtRootC45_14730	COG1175	transmembrane transport
NtRootC45_14740	COG1653	transport
NtRootC45_14750	COG1609	Transcriptional regulator
NtRootC45_14770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NtRootC45_14780	COG0750	zinc metalloprotease
NtRootC45_14800	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NtRootC45_14830	COG1309	transcriptional regulator
NtRootC45_14870	COG0442	prolyl-tRNA aminoacylation
NtRootC45_14920	COG0779	Required for maturation of 30S ribosomal subunits
NtRootC45_14950	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NtRootC45_14950	COG0481	GTPase activity
NtRootC45_14960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NtRootC45_14970	COG0590	tRNA wobble adenosine to inosine editing
NtRootC45_14990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NtRootC45_15030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NtRootC45_15040	COG1185	polyribonucleotide nucleotidyltransferase activity
NtRootC45_15050	COG0612	Peptidase, M16
NtRootC45_15090	COG0745	RESPONSE REGULATOR receiver
NtRootC45_15100	COG2205	protein histidine kinase activity
NtRootC45_15140	COG0521	Mo-molybdopterin cofactor biosynthetic process
NtRootC45_15160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NtRootC45_15200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NtRootC45_15210	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NtRootC45_15220	COG1674	ftsk spoiiie
NtRootC45_15240	COG1546	Belongs to the CinA family
NtRootC45_15240	COG1058	Belongs to the CinA family
NtRootC45_15250	COG1396	sequence-specific DNA binding
NtRootC45_15280	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NtRootC45_15290	COG2137	regulation of response to DNA damage stimulus
NtRootC45_15300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NtRootC45_15310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NtRootC45_15320	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NtRootC45_15330	COG2813	Specifically methylates the guanine in position
NtRootC45_15340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NtRootC45_15360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NtRootC45_15370	COG1388	LysM domain
NtRootC45_15390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NtRootC45_15400	COG0131	Imidazoleglycerol-phosphate dehydratase
NtRootC45_15410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NtRootC45_15430	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NtRootC45_15480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NtRootC45_15490	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NtRootC45_15500	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NtRootC45_15510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NtRootC45_15530	COG2814	Major facilitator Superfamily
NtRootC45_15600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NtRootC45_15610	COG0072	phenylalanine-tRNA ligase activity
NtRootC45_15610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NtRootC45_15620	COG3591	Belongs to the peptidase S1B family
NtRootC45_15690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NtRootC45_15700	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NtRootC45_15710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NtRootC45_15720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NtRootC45_15730	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NtRootC45_15740	COG1438	arginine binding
NtRootC45_15750	COG0137	argininosuccinate synthase activity
NtRootC45_15760	COG0165	Argininosuccinate lyase
NtRootC45_15790	COG2094	Belongs to the DNA glycosylase MPG family
NtRootC45_15810	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NtRootC45_15850	COG1011	Hydrolase
NtRootC45_15880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NtRootC45_15890	COG0497	DNA recombination
NtRootC45_15900	COG0504	CTP synthase activity
NtRootC45_15970	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NtRootC45_15980	COG2079	MmgE PrpD family protein
NtRootC45_16010	COG3290	protein histidine kinase activity
NtRootC45_16020	COG1301	dicarboxylic acid transport
NtRootC45_16040	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NtRootC45_16050	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NtRootC45_16080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NtRootC45_16100	COG1160	GTP binding
NtRootC45_16120	COG2814	Major facilitator Superfamily
NtRootC45_16140	COG0509	glycine decarboxylation via glycine cleavage system
NtRootC45_16150	COG1716	ATPase activity
NtRootC45_16200	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NtRootC45_16220	COG1940	carbohydrate kinase activity
NtRootC45_16270	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NtRootC45_16280	COG2815	serine threonine protein kinase
NtRootC45_16280	COG0515	serine threonine protein kinase
NtRootC45_16290	COG3942	CHAP domain
NtRootC45_16290	COG1388	LysM domain
NtRootC45_16320	COG0142	geranyltranstransferase activity
NtRootC45_16350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NtRootC45_16370	COG2001	Belongs to the MraZ family
NtRootC45_16380	COG0275	rRNA processing
NtRootC45_16400	COG0768	penicillin binding
NtRootC45_16410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NtRootC45_16430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NtRootC45_16440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NtRootC45_16460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NtRootC45_16470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NtRootC45_16490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NtRootC45_16510	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NtRootC45_16520	COG1799	cell septum assembly
NtRootC45_16550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NtRootC45_16600	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NtRootC45_16610	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NtRootC45_16620	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_16660	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NtRootC45_16670	COG0174	glutamine synthetase
NtRootC45_16680	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NtRootC45_16750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NtRootC45_16760	COG0321	lipoyl(octanoyl) transferase activity
NtRootC45_16770	COG0515	serine threonine protein kinase
NtRootC45_16770	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NtRootC45_16790	COG4946	Tricorn protease homolog
NtRootC45_16790	COG0793	Belongs to the peptidase S41A family
NtRootC45_16800	COG1764	response to oxidative stress
NtRootC45_16830	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootC45_16840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NtRootC45_16850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NtRootC45_16900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NtRootC45_16960	COG1271	oxidase subunit
NtRootC45_16970	COG1294	oxidase, subunit
NtRootC45_16980	COG4988	ABC transporter
NtRootC45_17020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NtRootC45_17030	COG0045	succinate-CoA ligase (ADP-forming) activity
NtRootC45_17030	COG1042	CoA-binding domain protein
NtRootC45_17030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NtRootC45_17060	COG1435	thymidine kinase activity
NtRootC45_17110	COG0756	dUTP diphosphatase activity
NtRootC45_17160	COG0569	domain protein
NtRootC45_17180	COG0531	amino acid
NtRootC45_17190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NtRootC45_17200	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NtRootC45_17210	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NtRootC45_17250	COG0667	Aldo Keto reductase
NtRootC45_17260	COG1024	Enoyl-CoA hydratase
NtRootC45_17260	COG1250	3-hydroxyacyl-CoA dehydrogenase
NtRootC45_17270	COG0183	Belongs to the thiolase family
NtRootC45_17330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NtRootC45_17360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NtRootC45_17390	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NtRootC45_17400	COG3135	benzoate transporter
NtRootC45_17420	COG0531	amino acid
NtRootC45_17440	COG0242	peptide deformylase activity
NtRootC45_17450	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NtRootC45_17470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NtRootC45_17510	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NtRootC45_17510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NtRootC45_17530	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NtRootC45_17540	COG0140	phosphoribosyl-ATP diphosphatase activity
NtRootC45_17550	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NtRootC45_17560	COG0107	imidazoleglycerol-phosphate synthase activity
NtRootC45_17580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NtRootC45_17620	COG0134	indole-3-glycerol-phosphate synthase activity
NtRootC45_17630	COG0133	tryptophan synthase activity
NtRootC45_17640	COG0159	tryptophan synthase activity
NtRootC45_17650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NtRootC45_17660	COG0070	glutamate synthase
NtRootC45_17660	COG0069	glutamate synthase activity
NtRootC45_17660	COG0067	glutamate synthase
NtRootC45_17740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NtRootC45_17750	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootC45_17760	COG0145	ligase activity
NtRootC45_17800	COG1012	belongs to the aldehyde dehydrogenase family
NtRootC45_17810	COG0673	inositol 2-dehydrogenase activity
NtRootC45_17820	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_17830	COG0129	dihydroxy-acid dehydratase activity
NtRootC45_17840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootC45_17860	COG0673	inositol 2-dehydrogenase activity
NtRootC45_17880	COG1129	ABC transporter
NtRootC45_17890	COG1172	Belongs to the binding-protein-dependent transport system permease family
NtRootC45_17910	COG0277	FAD linked oxidase domain protein
NtRootC45_17910	COG0247	lactate metabolic process
NtRootC45_17970	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NtRootC45_18000	COG0800	Aldolase
NtRootC45_18020	COG1609	Transcriptional regulator
NtRootC45_18090	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_18110	COG0395	ABC-type sugar transport system, permease component
NtRootC45_18140	COG1760	l-serine dehydratase
NtRootC45_18170	COG2814	Major facilitator Superfamily
NtRootC45_18210	COG1733	regulation of RNA biosynthetic process
NtRootC45_18300	COG0443	Heat shock 70 kDa protein
NtRootC45_18310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NtRootC45_18340	COG0542	response to heat
NtRootC45_18370	COG0747	negative chemotaxis
NtRootC45_18380	COG0601	transmembrane transport
NtRootC45_18390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootC45_18400	COG0444	Belongs to the ABC transporter superfamily
NtRootC45_18410	COG4608	Belongs to the ABC transporter superfamily
NtRootC45_18430	COG1621	beta-fructofuranosidase activity
NtRootC45_18460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NtRootC45_18470	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_18490	COG0251	oxidation-reduction process
NtRootC45_18540	COG1802	Transcriptional regulator
NtRootC45_18560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NtRootC45_18580	COG1126	abc transporter atp-binding protein
NtRootC45_18590	COG0765	amino acid transport
NtRootC45_18600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootC45_18620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NtRootC45_18630	COG1012	belongs to the aldehyde dehydrogenase family
NtRootC45_18640	COG0473	3-isopropylmalate dehydrogenase activity
NtRootC45_18670	COG1064	alcohol dehydrogenase
NtRootC45_18680	COG0747	negative chemotaxis
NtRootC45_18700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootC45_18710	COG4172	Belongs to the ABC transporter superfamily
NtRootC45_18720	COG1309	transcriptional regulator
NtRootC45_18740	COG0604	alcohol dehydrogenase
NtRootC45_18740	COG3321	synthase
NtRootC45_18900	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NtRootC45_18960	COG1063	alcohol dehydrogenase
NtRootC45_18970	COG2217	Heavy metal translocating P-type atpase
NtRootC45_18990	COG0857	belongs to the CobB CobQ family
NtRootC45_18990	COG0280	phosphate acetyltransferase
NtRootC45_19000	COG0589	response to stress
NtRootC45_19010	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NtRootC45_19040	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NtRootC45_19050	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NtRootC45_19070	COG0464	growth
NtRootC45_19200	COG1012	belongs to the aldehyde dehydrogenase family
NtRootC45_19250	COG2828	Protein conserved in bacteria
NtRootC45_19270	COG0673	inositol 2-dehydrogenase activity
NtRootC45_19290	COG0395	ABC-type sugar transport system, permease component
NtRootC45_19320	COG1609	Transcriptional regulator
NtRootC45_19340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NtRootC45_19350	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootC45_19360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NtRootC45_19380	COG0475	glutathione-regulated potassium exporter activity
NtRootC45_19410	COG0028	Belongs to the TPP enzyme family
NtRootC45_19440	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NtRootC45_19540	COG1012	belongs to the aldehyde dehydrogenase family
NtRootC45_19550	COG2084	Dehydrogenase
NtRootC45_19560	COG1737	Transcriptional regulator
NtRootC45_19580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NtRootC45_19600	COG3795	YCII-related domain
NtRootC45_19610	COG4941	Belongs to the sigma-70 factor family
NtRootC45_19640	COG1064	alcohol dehydrogenase
NtRootC45_19650	COG1643	Atp-dependent helicase
NtRootC45_19660	COG1228	amidohydrolase
NtRootC45_19730	COG0009	L-threonylcarbamoyladenylate synthase
NtRootC45_19770	COG2971	BadF BadG BcrA BcrD
NtRootC45_19790	COG1414	Transcriptional regulator
NtRootC45_19810	COG1053	succinate dehydrogenase
NtRootC45_19830	COG0477	Major facilitator Superfamily
NtRootC45_19860	COG3483	tryptophan 2,3-dioxygenase activity
NtRootC45_19930	COG2050	protein possibly involved in aromatic compounds catabolism
NtRootC45_19950	COG4552	Acetyltransferase involved in intracellular survival and related
NtRootC45_19970	COG0539	negative regulation of cytoplasmic translation
NtRootC45_19980	COG1739	Uncharacterized protein family UPF0029
NtRootC45_19990	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NtRootC45_19990	COG0237	dephospho-CoA kinase activity
NtRootC45_20000	COG0556	nucleotide-excision repair
NtRootC45_20020	COG0477	Major facilitator Superfamily
NtRootC45_20040	COG0456	acetyltransferase
NtRootC45_20050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NtRootC45_20070	COG4106	trans-aconitate 2-methyltransferase activity
NtRootC45_20100	COG0546	phosphoglycolate phosphatase activity
NtRootC45_20120	COG0322	excinuclease ABC activity
NtRootC45_20130	COG1660	Displays ATPase and GTPase activities
NtRootC45_20150	COG1481	regulation of sporulation
NtRootC45_20160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NtRootC45_20170	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NtRootC45_20180	COG0126	phosphoglycerate kinase activity
NtRootC45_20190	COG0149	triose-phosphate isomerase activity
NtRootC45_20200	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NtRootC45_20220	COG0363	glucosamine-6-phosphate deaminase activity
NtRootC45_20250	COG0166	Belongs to the GPI family
NtRootC45_20260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NtRootC45_20280	COG0109	protoheme IX farnesyltransferase activity
NtRootC45_20320	COG0577	efflux transmembrane transporter activity
NtRootC45_20320	COG1136	(ABC) transporter
NtRootC45_20330	COG1612	heme a metabolic process
NtRootC45_20340	COG0842	Transport permease protein
NtRootC45_20350	COG1131	(ABC) transporter
NtRootC45_20380	COG0719	Fe-S assembly protein
NtRootC45_20400	COG0396	ATPase activity
NtRootC45_20410	COG2151	metal-sulfur cluster biosynthetic enzyme
NtRootC45_20430	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootC45_20460	COG1122	ATPase activity
NtRootC45_20470	COG1268	BioY protein
NtRootC45_20480	COG0488	(ABC) transporter
NtRootC45_20530	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_20540	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_20550	COG1129	ABC transporter
NtRootC45_20580	COG0560	Phosphoserine phosphatase
NtRootC45_20580	COG3830	Belongs to the UPF0237 family
NtRootC45_20590	COG1119	ATPase activity
NtRootC45_20620	COG0254	rRNA binding
NtRootC45_20630	COG0095	Lipoate-protein ligase
NtRootC45_20670	COG2855	membrane
NtRootC45_20720	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NtRootC45_20740	COG0297	glycogen (starch) synthase activity
NtRootC45_20770	COG0183	Belongs to the thiolase family
NtRootC45_20800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NtRootC45_20840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NtRootC45_20850	COG0673	inositol 2-dehydrogenase activity
NtRootC45_20860	COG1088	dTDP-glucose 4,6-dehydratase activity
NtRootC45_20870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NtRootC45_21000	COG1088	dTDP-glucose 4,6-dehydratase activity
NtRootC45_21010	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NtRootC45_21020	COG0667	Aldo Keto reductase
NtRootC45_21030	COG1968	undecaprenyl-diphosphatase activity
NtRootC45_21040	COG0215	cysteine-tRNA ligase activity
NtRootC45_21060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NtRootC45_21070	COG1994	Peptidase M50
NtRootC45_21070	COG0517	IMP dehydrogenase activity
NtRootC45_21090	COG1222	aaa ATPase
NtRootC45_21100	COG4122	O-methyltransferase activity
NtRootC45_21120	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NtRootC45_21130	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NtRootC45_21140	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NtRootC45_21150	COG0545	Peptidyl-prolyl cis-trans isomerase
NtRootC45_21190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NtRootC45_21200	COG0805	protein transport
NtRootC45_21210	COG4581	dead DEAH box helicase
NtRootC45_21220	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NtRootC45_21230	COG1216	Glycosyl transferase, family 2
NtRootC45_21280	COG4946	Tricorn protease homolog
NtRootC45_21280	COG1506	peptidase
NtRootC45_21280	COG0823	Involved in the tonB-independent uptake of proteins
NtRootC45_21290	COG0242	peptide deformylase activity
NtRootC45_21330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NtRootC45_21340	COG3424	synthase
NtRootC45_21350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NtRootC45_21430	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NtRootC45_21440	COG1845	cytochrome c oxidase, subunit III
NtRootC45_21450	COG2010	Cytochrome c
NtRootC45_21460	COG0723	plastoquinol--plastocyanin reductase activity
NtRootC45_21470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NtRootC45_21500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NtRootC45_21520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NtRootC45_21530	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NtRootC45_21570	COG0167	dihydroorotate dehydrogenase activity
NtRootC45_21610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NtRootC45_21620	COG1381	Involved in DNA repair and RecF pathway recombination
NtRootC45_21630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NtRootC45_21640	COG3590	peptidase
NtRootC45_21650	COG1316	TRANSCRIPTIONal
NtRootC45_21660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NtRootC45_21680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NtRootC45_21720	COG0484	heat shock protein binding
NtRootC45_21730	COG1420	regulation of RNA biosynthetic process
NtRootC45_21760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NtRootC45_21770	COG0481	GTPase activity
NtRootC45_21790	COG0268	Binds directly to 16S ribosomal RNA
NtRootC45_21840	COG1307	EDD domain protein, DegV family
NtRootC45_21850	COG0495	leucyl-tRNA aminoacylation
NtRootC45_21860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NtRootC45_21870	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NtRootC45_21880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NtRootC45_21900	COG2390	Transcriptional regulator
NtRootC45_21910	COG0656	L-ascorbic acid biosynthetic process
NtRootC45_21930	COG0438	transferase activity, transferring glycosyl groups
NtRootC45_21950	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NtRootC45_21970	COG1758	RNA polymerase activity
NtRootC45_21980	COG0194	GDP metabolic process
NtRootC45_22000	COG0284	orotidine-5'-phosphate decarboxylase activity
NtRootC45_22010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NtRootC45_22020	COG0505	Belongs to the CarA family
NtRootC45_22040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NtRootC45_22050	COG0540	Belongs to the ATCase OTCase family
NtRootC45_22060	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NtRootC45_22080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NtRootC45_22090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NtRootC45_22110	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NtRootC45_22120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NtRootC45_22130	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NtRootC45_22140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NtRootC45_22170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NtRootC45_22200	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NtRootC45_22240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NtRootC45_22250	COG0124	histidyl-tRNA synthetase
NtRootC45_22270	COG1196	nuclear chromosome segregation
NtRootC45_22290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NtRootC45_22300	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NtRootC45_22310	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NtRootC45_22330	COG2255	four-way junction helicase activity
NtRootC45_22340	COG0632	four-way junction helicase activity
NtRootC45_22350	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NtRootC45_22360	COG0217	transcriptional regulatory protein
NtRootC45_22370	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NtRootC45_22410	COG0339	signal peptide processing
NtRootC45_22420	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NtRootC45_22430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NtRootC45_22450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NtRootC45_22460	COG0587	DNA-directed DNA polymerase activity
NtRootC45_22510	COG2135	peptidase activity
NtRootC45_22540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NtRootC45_22600	COG0644	oxidoreductase
NtRootC45_22630	COG4804	nuclease activity
NtRootC45_22650	COG3842	ATPase activity
NtRootC45_22680	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NtRootC45_22690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NtRootC45_22700	COG1780	Probably involved in ribonucleotide reductase function
NtRootC45_22720	COG0583	DNA-binding transcription factor activity
NtRootC45_22790	COG0714	Associated with various cellular activities
NtRootC45_22820	COG1175	transmembrane transport
NtRootC45_22850	COG2813	Specifically methylates the guanine in position
NtRootC45_22880	COG0799	negative regulation of ribosome biogenesis
NtRootC45_22900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NtRootC45_22920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NtRootC45_22930	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NtRootC45_22940	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NtRootC45_22950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NtRootC45_22960	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NtRootC45_22970	COG0351	phosphomethylpyrimidine kinase
NtRootC45_22970	COG0352	thiamine-phosphate diphosphorylase activity
NtRootC45_22970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NtRootC45_22980	COG1530	ribonuclease E activity
NtRootC45_23000	COG0105	UTP biosynthetic process
NtRootC45_23020	COG0285	dihydrofolate synthase activity
NtRootC45_23030	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NtRootC45_23060	COG0525	valine-tRNA ligase activity
NtRootC45_23070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NtRootC45_23080	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NtRootC45_23090	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NtRootC45_23100	COG0740	serine-type endopeptidase activity
NtRootC45_23110	COG0740	serine-type endopeptidase activity
NtRootC45_23120	COG0544	peptidyl-prolyl cis-trans isomerase activity
NtRootC45_23190	COG0668	transmembrane transport
NtRootC45_23220	COG1946	Acyl-CoA thioesterase
NtRootC45_23270	COG0629	single-stranded DNA binding
NtRootC45_23310	COG0242	peptide deformylase activity
NtRootC45_23360	COG3022	response to hydroperoxide
NtRootC45_23380	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NtRootC45_23390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NtRootC45_23410	COG1045	serine acetyltransferase
NtRootC45_23420	COG0300	oxidoreductase activity
NtRootC45_23430	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NtRootC45_23450	COG1063	alcohol dehydrogenase
NtRootC45_23460	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_23480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootC45_23500	COG0477	Major facilitator Superfamily
NtRootC45_23570	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NtRootC45_23600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NtRootC45_23610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NtRootC45_23640	COG4974	Belongs to the 'phage' integrase family
NtRootC45_23670	COG0792	nuclease activity
NtRootC45_23690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NtRootC45_23710	COG0681	Belongs to the peptidase S26 family
NtRootC45_23720	COG0335	large ribosomal subunit rRNA binding
NtRootC45_23730	COG0336	Belongs to the RNA methyltransferase TrmD family
NtRootC45_23740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NtRootC45_23750	COG1837	Belongs to the UPF0109 family
NtRootC45_23760	COG0228	four-way junction DNA binding
NtRootC45_23780	COG2514	catechol 2,3-dioxygenase activity
NtRootC45_23830	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NtRootC45_23860	COG2814	Major facilitator Superfamily
NtRootC45_23930	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NtRootC45_23940	COG0571	ribonuclease III activity
NtRootC45_23950	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NtRootC45_23970	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NtRootC45_24000	COG0742	ribosomal rna small subunit methyltransferase
NtRootC45_24020	COG1461	Dihydroxyacetone kinase
NtRootC45_24050	COG1181	Belongs to the D-alanine--D-alanine ligase family
NtRootC45_24060	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NtRootC45_24080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NtRootC45_24090	COG0066	3-isopropylmalate dehydratase activity
NtRootC45_24100	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NtRootC45_24110	COG1414	Transcriptional regulator
NtRootC45_24160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NtRootC45_24170	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootC45_24180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NtRootC45_24200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NtRootC45_24210	COG0473	3-isopropylmalate dehydrogenase activity
NtRootC45_24220	COG4585	Histidine kinase
NtRootC45_24230	COG2197	response regulator
NtRootC45_24240	COG1136	(ABC) transporter
NtRootC45_24240	COG0577	efflux transmembrane transporter activity
NtRootC45_24270	COG0577	efflux transmembrane transporter activity
NtRootC45_24270	COG1136	(ABC) transporter
NtRootC45_24290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NtRootC45_24300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NtRootC45_24310	COG0440	acetolactate synthase activity
NtRootC45_24330	COG0129	dihydroxy-acid dehydratase activity
NtRootC45_24350	COG0088	Forms part of the polypeptide exit tunnel
NtRootC45_24390	COG0747	negative chemotaxis
NtRootC45_24400	COG0579	oxidoreductase
NtRootC45_24410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NtRootC45_24420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootC45_24440	COG1305	Transglutaminase-like
NtRootC45_24480	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootC45_24500	COG1104	cysteine desulfurase activity
NtRootC45_24520	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NtRootC45_24530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NtRootC45_24550	COG1522	sequence-specific DNA binding
NtRootC45_24560	COG1113	amino acid transport
NtRootC45_24580	COG0022	dehydrogenase e1 component
NtRootC45_24590	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootC45_24630	COG0477	Major facilitator Superfamily
NtRootC45_24640	COG1414	Transcriptional regulator
NtRootC45_24690	COG1116	anion transmembrane transporter activity
NtRootC45_24700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NtRootC45_24730	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NtRootC45_24760	COG0419	ATPase involved in DNA repair
NtRootC45_24770	COG0420	3'-5' exonuclease activity
NtRootC45_24800	COG2149	membrane
NtRootC45_24850	COG1131	(ABC) transporter
NtRootC45_24880	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NtRootC45_24890	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NtRootC45_24900	COG1234	tRNA 3'-trailer cleavage
NtRootC45_24910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NtRootC45_24930	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NtRootC45_24950	COG1335	isochorismatase
NtRootC45_24980	COG0363	glucosamine-6-phosphate deaminase activity
NtRootC45_25010	COG1902	pentaerythritol trinitrate reductase activity
NtRootC45_25070	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
NtRootC45_25080	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NtRootC45_25100	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NtRootC45_25110	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NtRootC45_25130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NtRootC45_25140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NtRootC45_25150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NtRootC45_25160	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NtRootC45_25170	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NtRootC45_25180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NtRootC45_25190	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NtRootC45_25200	COG0356	it plays a direct role in the translocation of protons across the membrane
NtRootC45_25240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NtRootC45_25270	COG0009	L-threonylcarbamoyladenylate synthase
NtRootC45_25280	COG2890	protein-(glutamine-N5) methyltransferase activity
NtRootC45_25290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NtRootC45_25310	COG0083	homoserine kinase activity
NtRootC45_25320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NtRootC45_25330	COG0460	homoserine dehydrogenase
NtRootC45_25340	COG0019	diaminopimelate decarboxylase activity
NtRootC45_25350	COG0018	arginyl-trna synthetase
NtRootC45_25390	COG1017	nitric oxide dioxygenase activity
NtRootC45_25390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NtRootC45_25450	COG1643	Atp-dependent helicase
NtRootC45_25460	COG0537	adenosine 5'-monophosphoramidase activity
NtRootC45_25470	COG1064	alcohol dehydrogenase
NtRootC45_25510	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NtRootC45_25540	COG1121	(ABC) transporter
NtRootC45_25550	COG0803	Belongs to the bacterial solute-binding protein 9 family
NtRootC45_25570	COG1253	flavin adenine dinucleotide binding
NtRootC45_25580	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootC45_25580	COG0567	Dehydrogenase, E1 component
NtRootC45_25650	COG1595	DNA-templated transcription, initiation
NtRootC45_25670	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NtRootC45_25690	COG0483	inositol monophosphate 1-phosphatase activity
NtRootC45_25700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NtRootC45_25760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NtRootC45_25780	COG2177	Part of the ABC transporter FtsEX involved in
NtRootC45_25790	COG2884	Cell division ATP-binding protein ftsE
NtRootC45_25800	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NtRootC45_25920	COG1216	Glycosyl transferase, family 2
NtRootC45_25970	COG1216	Glycosyl transferase, family 2
NtRootC45_26020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NtRootC45_26050	COG0433	COG0433 Predicted ATPase
NtRootC45_26050	COG1674	ftsk spoiiie
NtRootC45_26090	COG2902	Dehydrogenase
NtRootC45_26160	COG0653	protein targeting
NtRootC45_26170	COG3214	Protein conserved in bacteria
NtRootC45_26180	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NtRootC45_26210	COG5401	PFAM Sporulation and spore germination
NtRootC45_26220	COG5002	protein histidine kinase activity
NtRootC45_26270	COG0714	Associated with various cellular activities
NtRootC45_26340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootC45_26350	COG0601	transmembrane transport
NtRootC45_26390	COG0482	sulfurtransferase activity
NtRootC45_26400	COG1053	succinate dehydrogenase
NtRootC45_26430	COG0446	pyridine nucleotide-disulphide oxidoreductase
NtRootC45_26430	COG1902	pentaerythritol trinitrate reductase activity
NtRootC45_26440	COG0673	inositol 2-dehydrogenase activity
NtRootC45_26460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NtRootC45_26470	COG0477	Major facilitator Superfamily
NtRootC45_26480	COG0583	DNA-binding transcription factor activity
NtRootC45_26520	COG0484	heat shock protein binding
NtRootC45_26530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NtRootC45_26540	COG1595	DNA-templated transcription, initiation
NtRootC45_26570	COG3265	gluconokinase activity
NtRootC45_26580	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NtRootC45_26590	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NtRootC45_26600	COG2086	electron transfer activity
NtRootC45_26610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NtRootC45_26640	COG1842	Phage shock protein A
NtRootC45_26660	COG1615	UPF0182 protein
NtRootC45_26670	COG3480	Lon protease (S16) C-terminal proteolytic domain
NtRootC45_26710	COG2816	NAD+ diphosphatase activity
NtRootC45_26770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootC45_26780	COG0765	amino acid transport
NtRootC45_26790	COG1126	abc transporter atp-binding protein
NtRootC45_26820	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NtRootC45_26840	COG0113	porphobilinogen synthase activity
NtRootC45_26860	COG0181	hydroxymethylbilane synthase activity
NtRootC45_26870	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NtRootC45_26880	COG3253	May function as heme-dependent peroxidase
NtRootC45_26890	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NtRootC45_26900	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NtRootC45_26910	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NtRootC45_26940	COG1309	transcriptional regulator
NtRootC45_27000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NtRootC45_27000	COG2022	thiamine diphosphate biosynthetic process
NtRootC45_27010	COG0352	thiamine-phosphate diphosphorylase activity
NtRootC45_27030	COG2267	carboxylic ester hydrolase activity
NtRootC45_27050	COG0513	Belongs to the DEAD box helicase family
NtRootC45_27070	COG2095	MarC family integral membrane protein
NtRootC45_27090	COG0006	proline dipeptidase activity
NtRootC45_27110	COG2239	Acts as a magnesium transporter
NtRootC45_27140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NtRootC45_27160	COG1595	DNA-templated transcription, initiation
NtRootC45_27220	COG1126	abc transporter atp-binding protein
NtRootC45_27240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootC45_27250	COG0765	amino acid transport
NtRootC45_27260	COG0765	amino acid transport
NtRootC45_27270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NtRootC45_27280	COG2171	N-acyltransferase activity
NtRootC45_27310	COG3226	Transcriptional regulator
NtRootC45_27320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NtRootC45_27380	COG1217	gtp-binding protein TYPA
NtRootC45_27410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NtRootC45_27430	COG4166	transmembrane transport
NtRootC45_27450	COG0012	GTP binding
NtRootC45_27460	COG1322	Protein conserved in bacteria
NtRootC45_27470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NtRootC45_27490	COG1570	exodeoxyribonuclease VII activity
NtRootC45_27500	COG1722	exodeoxyribonuclease VII activity
NtRootC45_27510	COG2326	polyphosphate kinase activity
NtRootC45_27550	COG1174	glycine betaine transport
NtRootC45_27570	COG1162	GTPase activity
NtRootC45_27620	COG2971	BadF BadG BcrA BcrD
NtRootC45_27640	COG0583	DNA-binding transcription factor activity
NtRootC45_27650	COG2814	Major facilitator Superfamily
NtRootC45_27660	COG3548	integral membrane protein
NtRootC45_27710	COG0598	Magnesium transport protein CorA
NtRootC45_27730	COG1528	Iron-storage protein
NtRootC45_27740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NtRootC45_27750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NtRootC45_27770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NtRootC45_27780	COG1695	Transcriptional regulator
NtRootC45_27980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NtRootC45_28090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NtRootC45_28100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NtRootC45_28110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NtRootC45_28150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NtRootC45_28150	COG0519	Catalyzes the synthesis of GMP from XMP
NtRootC45_28190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NtRootC45_28200	COG0516	GMP reductase activity
NtRootC45_28240	COG1132	(ABC) transporter
NtRootC45_28280	COG0459	protein refolding
NtRootC45_28290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NtRootC45_28320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NtRootC45_28330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NtRootC45_28350	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NtRootC45_28360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NtRootC45_28390	COG0802	atpase or kinase
NtRootC45_28400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NtRootC45_28440	COG0438	transferase activity, transferring glycosyl groups
NtRootC45_28450	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NtRootC45_28470	COG0667	Aldo Keto reductase
NtRootC45_28520	COG0736	holo-[acyl-carrier-protein] synthase activity
NtRootC45_28540	COG1072	(Pantothenic acid kinase))
NtRootC45_28560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NtRootC45_28570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NtRootC45_28580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NtRootC45_28620	COG2894	cell division
NtRootC45_28680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NtRootC45_28700	COG0101	tRNA pseudouridine synthase activity
NtRootC45_28710	COG0203	ribosomal protein L17
NtRootC45_28720	COG0202	RNA polymerase activity
NtRootC45_28730	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NtRootC45_28740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NtRootC45_28750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NtRootC45_28760	COG3191	aminopeptidase activity
NtRootC45_28820	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootC45_28830	COG2124	cytochrome p450
NtRootC45_28840	COG1216	Glycosyl transferase, family 2
NtRootC45_28850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NtRootC45_28860	COG0563	adenylate kinase activity
NtRootC45_28880	COG0200	Binds to the 23S rRNA
NtRootC45_28890	COG1841	ribosomal large subunit assembly
NtRootC45_28900	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NtRootC45_28920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NtRootC45_28930	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NtRootC45_28940	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NtRootC45_28950	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NtRootC45_28960	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NtRootC45_28970	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NtRootC45_28980	COG0255	Belongs to the universal ribosomal protein uL29 family
NtRootC45_28990	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NtRootC45_29000	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NtRootC45_29010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NtRootC45_29020	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NtRootC45_29030	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NtRootC45_29040	COG0089	rRNA binding
NtRootC45_29050	COG0088	Forms part of the polypeptide exit tunnel
NtRootC45_29060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NtRootC45_29070	COG0051	transcription antitermination factor activity, RNA binding
NtRootC45_29110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NtRootC45_29120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NtRootC45_29130	COG0049	tRNA binding
NtRootC45_29140	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NtRootC45_29150	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NtRootC45_29160	COG0085	RNA polymerase activity
NtRootC45_29170	COG0183	Belongs to the thiolase family
NtRootC45_29180	COG0442	prolyl-tRNA aminoacylation
NtRootC45_29190	COG0222	ribosome binding
NtRootC45_29200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NtRootC45_29240	COG0081	regulation of translation
NtRootC45_29250	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NtRootC45_29280	COG0436	Aminotransferase
NtRootC45_29290	COG2197	response regulator
NtRootC45_29410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NtRootC45_29430	COG3485	protocatechuate 3,4-dioxygenase
NtRootC45_29460	COG0745	RESPONSE REGULATOR receiver
NtRootC45_29470	COG0456	acetyltransferase
NtRootC45_29480	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NtRootC45_29490	COG0406	alpha-ribazole phosphatase activity
NtRootC45_29490	COG0494	nUDIX hydrolase
NtRootC45_29530	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NtRootC45_29540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NtRootC45_29560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NtRootC45_29600	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NtRootC45_29610	COG0738	Major facilitator superfamily
NtRootC45_29630	COG2030	dehydratase
NtRootC45_29690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NtRootC45_29710	COG4989	oxidoreductase activity
NtRootC45_29720	COG0366	Alpha amylase catalytic
NtRootC45_29730	COG0395	ABC-type sugar transport system, permease component
NtRootC45_29740	COG1175	transmembrane transport
NtRootC45_29760	COG1940	carbohydrate kinase activity
NtRootC45_29790	COG1376	ErfK ybiS ycfS ynhG family protein
NtRootC45_29850	COG0754	glutathionylspermidine amidase activity
NtRootC45_29870	COG5650	phosphatidylinositol metabolic process
NtRootC45_29910	COG1175	transmembrane transport
NtRootC45_29920	COG0395	ABC-type sugar transport system, permease component
NtRootC45_29970	COG5650	phosphatidylinositol metabolic process
NtRootC45_30030	COG0318	PFAM AMP-dependent synthetase and ligase
NtRootC45_30050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NtRootC45_30060	COG1309	transcriptional regulator
NtRootC45_30070	COG1131	(ABC) transporter
NtRootC45_30110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NtRootC45_30130	COG1666	GTP binding
NtRootC45_30140	COG0672	)-iron permease
NtRootC45_30160	COG2837	iron assimilation
NtRootC45_30190	COG0501	Belongs to the peptidase M48B family
NtRootC45_30250	COG0531	amino acid
NtRootC45_30350	COG0395	ABC-type sugar transport system, permease component
NtRootC45_30360	COG4209	transmembrane transport
NtRootC45_30380	COG1609	Transcriptional regulator
NtRootC45_30420	COG1012	belongs to the aldehyde dehydrogenase family
NtRootC45_30430	COG3835	regulator
NtRootC45_30440	COG2807	transmembrane transport
NtRootC45_30450	COG2186	Transcriptional regulator
NtRootC45_30460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NtRootC45_30460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NtRootC45_30480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NtRootC45_30480	COG1648	precorrin-2 dehydrogenase activity
NtRootC45_30490	COG2066	Belongs to the glutaminase family
NtRootC45_30500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootC45_30550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NtRootC45_30560	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NtRootC45_30580	COG2040	homocysteine
NtRootC45_30590	COG2895	sulfate adenylyltransferase (ATP) activity
NtRootC45_30610	COG0175	sulfate reduction
NtRootC45_30640	COG2860	membrane
NtRootC45_30670	COG0142	geranyltranstransferase activity
NtRootC45_30690	COG2226	methyltransferase
NtRootC45_30700	COG1169	isochorismate synthase
NtRootC45_30710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootC45_30720	COG0765	amino acid transport
NtRootC45_30750	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NtRootC45_30770	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootC45_30830	COG0395	ABC-type sugar transport system, permease component
NtRootC45_30840	COG1175	transmembrane transport
NtRootC45_30930	COG1404	Belongs to the peptidase S8 family
NtRootC45_30990	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootC45_31000	COG0022	dehydrogenase e1 component
NtRootC45_31040	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NtRootC45_31060	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NtRootC45_31070	COG1088	dTDP-glucose 4,6-dehydratase activity
NtRootC45_31090	COG0489	protein tyrosine kinase activity
NtRootC45_31170	COG0438	transferase activity, transferring glycosyl groups
NtRootC45_31170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NtRootC45_31190	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NtRootC45_31270	COG2267	carboxylic ester hydrolase activity
NtRootC45_31290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NtRootC45_31300	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NtRootC45_31310	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NtRootC45_31320	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NtRootC45_31440	COG1846	Transcriptional regulator
NtRootC45_31450	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NtRootC45_31490	COG1063	alcohol dehydrogenase
NtRootC45_31520	COG0667	Aldo Keto reductase
NtRootC45_31580	COG1024	Enoyl-CoA hydratase
NtRootC45_31590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NtRootC45_31600	COG2151	metal-sulfur cluster biosynthetic enzyme
NtRootC45_31610	COG3396	Phenylacetate-CoA oxygenase
NtRootC45_31620	COG3460	Phenylacetate-CoA oxygenase
NtRootC45_31630	COG3396	Phenylacetate-CoA oxygenase
NtRootC45_31640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NtRootC45_31650	COG1388	LysM domain
NtRootC45_31650	COG3942	CHAP domain
NtRootC45_31670	COG3706	GGDEF domain
NtRootC45_31700	COG0438	transferase activity, transferring glycosyl groups
NtRootC45_31720	COG0438	transferase activity, transferring glycosyl groups
NtRootC45_31750	COG2226	methyltransferase
NtRootC45_31770	COG5002	protein histidine kinase activity
NtRootC45_31820	COG2050	protein possibly involved in aromatic compounds catabolism
NtRootC45_31850	COG1012	belongs to the aldehyde dehydrogenase family
NtRootC45_31850	COG2030	dehydratase
NtRootC45_31880	COG1250	3-hydroxyacyl-CoA dehydrogenase
NtRootC45_31890	COG1024	Enoyl-CoA hydratase
NtRootC45_31950	COG1266	CAAX protease self-immunity
NtRootC45_31970	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NtRootC45_32070	COG0443	Heat shock 70 kDa protein
NtRootC45_32080	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NtRootC45_32100	COG0785	Cytochrome C biogenesis protein
NtRootC45_32120	COG0406	alpha-ribazole phosphatase activity
NtRootC45_32180	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NtRootC45_32230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NtRootC45_32240	COG3458	cephalosporin-C deacetylase activity
NtRootC45_32260	COG2814	Major facilitator Superfamily
NtRootC45_32280	COG0395	ABC-type sugar transport system, permease component
NtRootC45_32290	COG1175	transmembrane transport
NtRootC45_32330	COG0395	ABC-type sugar transport system, permease component
NtRootC45_32340	COG1175	transmembrane transport
NtRootC45_32360	COG0673	inositol 2-dehydrogenase activity
NtRootC45_32390	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootC45_32400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NtRootC45_32420	COG0673	inositol 2-dehydrogenase activity
NtRootC45_32430	COG1609	Transcriptional regulator
NtRootC45_32460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NtRootC45_32470	COG0640	Transcriptional regulator
NtRootC45_32500	COG0123	including yeast histone deacetylase and acetoin utilization protein
NtRootC45_32510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NtRootC45_32520	COG0569	domain protein
NtRootC45_32530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NtRootC45_32540	COG1082	Xylose isomerase domain protein TIM barrel
NtRootC45_32550	COG0248	Ppx GppA phosphatase
NtRootC45_32570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NtRootC45_32570	COG1754	DNA topoisomerase type I activity
NtRootC45_32620	COG1054	Belongs to the UPF0176 family
NtRootC45_32640	COG1111	helicase
NtRootC45_32640	COG1205	dead DEAH box helicase
NtRootC45_32780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NtRootC45_32790	COG1349	DNA-binding transcription factor activity
NtRootC45_32820	COG2826	transposase and inactivated derivatives, IS30 family
NtRootC45_32830	COG1609	Transcriptional regulator
NtRootC45_32850	COG1175	transmembrane transport
NtRootC45_32860	COG0395	ABC-type sugar transport system, permease component
NtRootC45_32950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NtRootC45_32960	COG1408	metallophosphoesterase
NtRootC45_32970	COG1132	(ABC) transporter
NtRootC45_32980	COG1132	(ABC) transporter
NtRootC45_33020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NtRootC45_33030	COG0151	Belongs to the GarS family
NtRootC45_33070	COG1301	dicarboxylic acid transport
NtRootC45_33090	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_33110	COG1953	Uracil, thiamine, allantoin
NtRootC45_33120	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NtRootC45_33150	COG0454	-acetyltransferase
NtRootC45_33160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NtRootC45_33180	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NtRootC45_33180	COG3608	succinylglutamate desuccinylase aspartoacylase
NtRootC45_33190	COG2252	PERMEase
NtRootC45_33200	COG0590	tRNA wobble adenosine to inosine editing
NtRootC45_33270	COG2233	PERMEase
NtRootC45_33280	COG1414	Transcriptional regulator
NtRootC45_33300	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NtRootC45_33320	COG3257	ureidoglycine aminohydrolase activity
NtRootC45_33350	COG0395	ABC-type sugar transport system, permease component
NtRootC45_33370	COG1653	transport
NtRootC45_33390	COG3119	arylsulfatase activity
NtRootC45_33400	COG1609	Transcriptional regulator
NtRootC45_33410	COG5492	domain, Protein
NtRootC45_33420	COG3654	unkown
NtRootC45_33440	COG2318	DinB family
NtRootC45_33500	COG2271	Major facilitator Superfamily
NtRootC45_33530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NtRootC45_33530	COG4499	WXG100 protein secretion system (Wss), protein YukC
NtRootC45_33550	COG2814	Major facilitator Superfamily
NtRootC45_33580	COG0659	secondary active sulfate transmembrane transporter activity
NtRootC45_33660	COG0563	adenylate kinase activity
NtRootC45_33680	COG0477	Major facilitator Superfamily
NtRootC45_33700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NtRootC45_33720	COG3401	FG-GAP repeat protein
NtRootC45_33730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootC45_33770	COG2011	ABC-type metal ion transport system permease component
NtRootC45_33780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NtRootC45_33790	COG1464	Belongs to the NlpA lipoprotein family
NtRootC45_33800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootC45_33890	COG2267	carboxylic ester hydrolase activity
NtRootC45_33950	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NtRootC45_33960	COG1733	regulation of RNA biosynthetic process
NtRootC45_33970	COG3025	triphosphatase activity
NtRootC45_33970	COG5607	PFAM CHAD domain containing protein
NtRootC45_34050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NtRootC45_34130	COG0405	Gamma-glutamyltransferase
NtRootC45_34250	COG0673	inositol 2-dehydrogenase activity
NtRootC45_34270	COG0673	inositol 2-dehydrogenase activity
NtRootC45_34300	COG1653	transport
NtRootC45_34310	COG1609	Transcriptional regulator
NtRootC45_34380	COG3622	Belongs to the hyi family
NtRootC45_34390	COG2084	Dehydrogenase
NtRootC45_34400	COG3960	tartronate-semialdehyde synthase activity
NtRootC45_34410	COG1929	Belongs to the glycerate kinase type-1 family
NtRootC45_34420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NtRootC45_34430	COG0745	RESPONSE REGULATOR receiver
NtRootC45_34460	COG0745	RESPONSE REGULATOR receiver
NtRootC45_34470	COG1215	transferase activity, transferring glycosyl groups
NtRootC45_34480	COG1366	Belongs to the anti-sigma-factor antagonist family
NtRootC45_34500	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NtRootC45_34540	COG2814	Major facilitator Superfamily
NtRootC45_34560	COG0671	phosphoesterase, PA-phosphatase related
NtRootC45_34590	COG2826	transposase and inactivated derivatives, IS30 family
NtRootC45_34620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NtRootC45_34660	COG0542	response to heat
NtRootC45_34710	COG3585	molybdate ion transport
NtRootC45_34720	COG4585	Histidine kinase
NtRootC45_34730	COG2197	response regulator
NtRootC45_34790	COG3304	Inner membrane component domain
NtRootC45_34800	COG0135	phosphoribosylanthranilate isomerase activity
NtRootC45_34840	COG0667	Aldo Keto reductase
NtRootC45_34870	COG2814	Major facilitator Superfamily
NtRootC45_34890	COG2813	Specifically methylates the guanine in position
NtRootC45_34910	COG1473	amidohydrolase
NtRootC45_34920	COG0477	Major facilitator Superfamily
NtRootC45_34930	COG2807	transmembrane transport
NtRootC45_34960	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NtRootC45_35070	COG2188	Transcriptional regulator
NtRootC45_35140	COG1012	belongs to the aldehyde dehydrogenase family
NtRootC45_35170	COG0596	Alpha beta hydrolase
NtRootC45_35170	COG2945	thiolester hydrolase activity
NtRootC45_35180	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_35250	COG1846	Transcriptional regulator
NtRootC45_35260	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
NtRootC45_35270	COG0789	Transcriptional regulator
NtRootC45_35280	COG0484	heat shock protein binding
NtRootC45_35290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NtRootC45_35300	COG0443	Heat shock 70 kDa protein
NtRootC45_35310	COG3739	integral membrane protein
NtRootC45_35360	COG1917	Cupin 2, conserved barrel domain protein
NtRootC45_35360	COG4977	sequence-specific DNA binding
NtRootC45_35390	COG3540	Alkaline phosphatase
NtRootC45_35400	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
NtRootC45_35470	COG0531	amino acid
NtRootC45_35500	COG3226	Transcriptional regulator
NtRootC45_35510	COG1280	lysine exporter protein (LysE YggA)
NtRootC45_35560	COG0492	ferredoxin-NADP+ reductase activity
NtRootC45_35570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NtRootC45_35580	COG0798	PFAM Bile acid sodium symporter
NtRootC45_35590	COG0640	Transcriptional regulator
NtRootC45_35610	COG2409	Drug exporters of the RND superfamily
NtRootC45_35640	COG3795	YCII-related domain
NtRootC45_35660	COG4941	Belongs to the sigma-70 factor family
NtRootC45_35700	COG1280	lysine exporter protein (LysE YggA)
NtRootC45_35720	COG1609	Transcriptional regulator
NtRootC45_35730	COG1957	nucleoside hydrolase
NtRootC45_35740	COG0477	Major facilitator Superfamily
NtRootC45_35750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NtRootC45_35780	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NtRootC45_35800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NtRootC45_35820	COG0833	amino acid
NtRootC45_35830	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NtRootC45_35850	COG2986	histidine ammonia-lyase
NtRootC45_35910	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NtRootC45_35930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NtRootC45_35940	COG1132	(ABC) transporter
NtRootC45_35940	COG2375	cellular response to nickel ion
NtRootC45_35980	COG1122	ATPase activity
NtRootC45_35990	COG4721	ABC-type cobalt transport system, permease component
NtRootC45_36020	COG1320	monovalent cation:proton antiporter activity
NtRootC45_36030	COG2212	antiporter activity
NtRootC45_36050	COG0651	ATP synthesis coupled electron transport
NtRootC45_36060	COG1006	Multisubunit Na H antiporter MnhC subunit
NtRootC45_36070	COG2111	Na H antiporter
NtRootC45_36070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NtRootC45_36100	COG0475	glutathione-regulated potassium exporter activity
NtRootC45_36120	COG0717	Belongs to the dCTP deaminase family
NtRootC45_36150	COG1876	peptidase activity
NtRootC45_36160	COG0686	Belongs to the AlaDH PNT family
NtRootC45_36180	COG0583	DNA-binding transcription factor activity
NtRootC45_36200	COG0640	Transcriptional regulator
NtRootC45_36240	COG0657	acetylesterase activity
NtRootC45_36240	COG2755	lipolytic protein G-D-S-L family
NtRootC45_36250	COG1609	Transcriptional regulator
NtRootC45_36260	COG0673	inositol 2-dehydrogenase activity
NtRootC45_36320	COG2115	Belongs to the xylose isomerase family
NtRootC45_36330	COG1070	Carbohydrate kinase
NtRootC45_36340	COG1609	Transcriptional regulator
NtRootC45_36370	COG2160	L-arabinose isomerase activity
NtRootC45_36380	COG2017	converts alpha-aldose to the beta-anomer
NtRootC45_36400	COG2211	Major facilitator Superfamily
NtRootC45_36410	COG1846	Transcriptional regulator
NtRootC45_36410	COG1940	carbohydrate kinase activity
NtRootC45_36430	COG0765	amino acid transport
NtRootC45_36440	COG0765	amino acid transport
NtRootC45_36470	COG0251	oxidation-reduction process
NtRootC45_36500	COG0583	DNA-binding transcription factor activity
NtRootC45_36530	COG1609	Transcriptional regulator
NtRootC45_36540	COG3254	rhamnose metabolic process
NtRootC45_36560	COG3347	Dehydrogenase
NtRootC45_36560	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_36570	COG1070	Carbohydrate kinase
NtRootC45_36580	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NtRootC45_36600	COG3387	PFAM Glycoside hydrolase 15-related
NtRootC45_36610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootC45_36620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NtRootC45_36630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NtRootC45_36670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootC45_36680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootC45_36700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NtRootC45_36720	COG1126	abc transporter atp-binding protein
NtRootC45_36730	COG0765	amino acid transport
NtRootC45_36760	COG0433	COG0433 Predicted ATPase
NtRootC45_36790	COG3336	cytochrome c oxidase
NtRootC45_36800	COG0776	regulation of translation
NtRootC45_36850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NtRootC45_36860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NtRootC45_36870	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NtRootC45_36880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NtRootC45_36880	COG1017	nitric oxide dioxygenase activity
NtRootC45_36970	COG1120	ATPase activity
NtRootC45_36980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootC45_36990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NtRootC45_37070	COG3012	SEC-C Motif Domain Protein
NtRootC45_37100	COG0667	Aldo Keto reductase
NtRootC45_37180	COG2186	Transcriptional regulator
NtRootC45_37200	COG1027	Aspartate ammonia-lyase
NtRootC45_37250	COG3254	rhamnose metabolic process
NtRootC45_37270	COG4948	Mandelate Racemase Muconate Lactonizing
NtRootC45_37290	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_37310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NtRootC45_37340	COG4221	oxidoreductase activity
NtRootC45_37360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NtRootC45_37370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NtRootC45_37410	COG1522	sequence-specific DNA binding
NtRootC45_37420	COG1280	lysine exporter protein (LysE YggA)
NtRootC45_37440	COG0640	Transcriptional regulator
NtRootC45_37480	COG2826	transposase and inactivated derivatives, IS30 family
NtRootC45_37500	COG2826	transposase and inactivated derivatives, IS30 family
NtRootC45_37510	COG1414	Transcriptional regulator
NtRootC45_37530	COG0477	Major facilitator Superfamily
NtRootC45_37550	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NtRootC45_37600	COG1760	l-serine dehydratase
NtRootC45_37650	COG2826	transposase and inactivated derivatives, IS30 family
NtRootC45_37670	COG0281	malic enzyme
NtRootC45_37680	COG1309	transcriptional regulator
NtRootC45_37720	COG2211	Major facilitator Superfamily
NtRootC45_37730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NtRootC45_37740	COG0477	Major facilitator Superfamily
NtRootC45_37750	COG0477	Major facilitator Superfamily
NtRootC45_37760	COG2814	Major facilitator Superfamily
NtRootC45_37830	COG1113	amino acid transport
NtRootC45_37840	COG0246	Mannitol dehydrogenase
NtRootC45_37850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NtRootC45_37850	COG2213	PTS system mannitol-specific
NtRootC45_37870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NtRootC45_37910	COG0596	Alpha beta hydrolase
NtRootC45_37930	COG1793	dna ligase
NtRootC45_37970	COG0686	Belongs to the AlaDH PNT family
NtRootC45_38010	COG0673	inositol 2-dehydrogenase activity
NtRootC45_38060	COG1309	transcriptional regulator
NtRootC45_38070	COG0431	NADPH-dependent FMN reductase
NtRootC45_38120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NtRootC45_38160	COG0508	dehydrogenase complex catalyzes the overall conversion of
NtRootC45_38170	COG0022	dehydrogenase e1 component
NtRootC45_38190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NtRootC45_38200	COG1950	PFAM Membrane protein of
NtRootC45_38230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NtRootC45_38260	COG1607	acyl-coa hydrolase
NtRootC45_38270	COG4221	oxidoreductase activity
NtRootC45_38280	COG0477	Major facilitator Superfamily
NtRootC45_38290	COG1984	allophanate hydrolase subunit 2
NtRootC45_38300	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NtRootC45_38310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NtRootC45_38320	COG0583	DNA-binding transcription factor activity
NtRootC45_38340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NtRootC45_38350	COG0436	Aminotransferase
NtRootC45_38400	COG3971	2-oxopent-4-enoate hydratase activity
NtRootC45_38430	COG1802	Transcriptional regulator
NtRootC45_38440	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootC45_38500	COG2207	Transcriptional regulator
NtRootC45_38500	COG3708	Transcriptional regulator
NtRootC45_38510	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_38670	COG2205	protein histidine kinase activity
NtRootC45_38680	COG2815	serine threonine protein kinase
NtRootC45_38680	COG0515	serine threonine protein kinase
NtRootC45_38720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NtRootC45_38730	COG3387	PFAM Glycoside hydrolase 15-related
NtRootC45_38750	COG0076	glutamate decarboxylase activity
NtRootC45_38770	COG1011	Hydrolase
NtRootC45_38810	COG1414	Transcriptional regulator
NtRootC45_38820	COG2814	Major facilitator Superfamily
NtRootC45_38910	COG1846	Transcriptional regulator
NtRootC45_38970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NtRootC45_38980	COG1760	l-serine dehydratase
NtRootC45_38990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NtRootC45_39000	COG0509	glycine decarboxylation via glycine cleavage system
NtRootC45_39010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NtRootC45_39020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NtRootC45_39020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NtRootC45_39040	COG2271	Major facilitator Superfamily
NtRootC45_39060	COG1970	mechanosensitive ion channel activity
NtRootC45_39370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NtRootC45_39390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NtRootC45_39440	COG2826	transposase and inactivated derivatives, IS30 family
NtRootC45_39450	COG2814	Major facilitator Superfamily
NtRootC45_39470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NtRootC45_39500	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootC45_39510	COG0251	oxidation-reduction process
NtRootC45_39530	COG1414	Transcriptional regulator
NtRootC45_39540	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NtRootC45_39560	COG0183	Belongs to the thiolase family
NtRootC45_39570	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NtRootC45_39580	COG2267	carboxylic ester hydrolase activity
NtRootC45_39610	COG3485	protocatechuate 3,4-dioxygenase
NtRootC45_39620	COG1082	Xylose isomerase domain protein TIM barrel
NtRootC45_39620	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NtRootC45_39630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NtRootC45_39640	COG1414	Transcriptional regulator
NtRootC45_39680	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NtRootC45_39700	COG3706	GGDEF domain
NtRootC45_39760	COG0583	DNA-binding transcription factor activity
NtRootC45_39830	COG2610	gluconate transmembrane transporter activity
NtRootC45_39840	COG0800	Aldolase
NtRootC45_39850	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
NtRootC45_39880	COG1414	Transcriptional regulator
NtRootC45_39970	COG2326	polyphosphate kinase activity
NtRootC45_39990	COG1737	Transcriptional regulator
NtRootC45_40000	COG3876	Protein conserved in bacteria
NtRootC45_40010	COG1472	Belongs to the glycosyl hydrolase 3 family
NtRootC45_40050	COG1937	Protein conserved in bacteria
NtRootC45_40060	COG2217	Heavy metal translocating P-type atpase
NtRootC45_40170	COG0534	Mate efflux family protein
NtRootC45_40190	COG2259	Doxx family
NtRootC45_40220	COG3848	Pyruvate phosphate dikinase
NtRootC45_40220	COG0574	Belongs to the PEP-utilizing enzyme family
NtRootC45_40240	COG1607	acyl-coa hydrolase
NtRootC45_40270	COG3958	Transketolase
NtRootC45_40280	COG3959	Transketolase, thiamine diphosphate binding domain
NtRootC45_40310	COG1028	Short-chain dehydrogenase reductase Sdr
NtRootC45_40320	COG2376	Dihydroxyacetone kinase
NtRootC45_40330	COG0698	ribose 5-phosphate isomerase
NtRootC45_40360	COG0305	Participates in initiation and elongation during chromosome replication
NtRootC45_40440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NtRootC45_40450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NtRootC45_40520	COG1131	(ABC) transporter
NtRootC45_40540	COG0384	phenazine biosynthesis protein PhzF
NtRootC45_40560	COG2826	transposase and inactivated derivatives, IS30 family
NtRootC45_40570	COG0359	binds to the 23S rRNA
NtRootC45_40580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NtRootC45_40600	COG0360	Binds together with S18 to 16S ribosomal RNA
NtRootC45_40630	COG1113	amino acid transport
NtRootC45_40640	COG1362	aminopeptidase activity
NtRootC45_40710	COG0833	amino acid
NtRootC45_40720	COG2197	response regulator
NtRootC45_40730	COG4585	Histidine kinase
NtRootC45_40750	COG1131	(ABC) transporter
NtRootC45_40760	COG1597	lipid kinase activity
NtRootC45_40780	COG0738	Major facilitator superfamily
NtRootC45_40820	COG0768	penicillin binding
NtRootC45_40830	COG1501	Belongs to the glycosyl hydrolase 31 family
NtRootC45_40840	COG2197	response regulator
NtRootC45_40850	COG4585	Histidine kinase
NtRootC45_40870	COG1136	(ABC) transporter
NtRootC45_40880	COG1733	regulation of RNA biosynthetic process
NtRootC45_40890	COG2910	NAD(P)H-binding
NtRootC45_40930	COG0406	alpha-ribazole phosphatase activity
NtRootC45_40940	COG0617	tRNA 3'-terminal CCA addition
NtRootC45_40980	COG0492	ferredoxin-NADP+ reductase activity
NtRootC45_40990	COG3118	belongs to the thioredoxin family
NtRootC45_41040	COG1192	Involved in chromosome partitioning
NtRootC45_41050	COG0357	Ribosomal RNA small subunit methyltransferase G
NtRootC45_41070	COG0706	membrane insertase activity
NtRootC45_41080	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NtRootC45_41090	COG0594	ribonuclease P activity
NtRootC45_41100	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NtRootC45_41130	COG3608	succinylglutamate desuccinylase aspartoacylase
NtRootC45_41130	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NtRootC45_41350	COG2801	Transposase and inactivated derivatives
NtRootC45_41350	COG3415	Transposase
NtRootC45_41480	COG2211	Major facilitator Superfamily
NtRootC45_41890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NtRootC45_41950	COG1793	dna ligase
NtRootC45_41980	COG2267	carboxylic ester hydrolase activity
NtRootC45_42000	COG0657	acetylesterase activity
NtRootC45_42010	COG2814	Major facilitator Superfamily
NtRootC45_42020	COG1609	Transcriptional regulator
NtRootC45_42030	COG1475	DNA binding
NtRootC45_42150	COG2720	vancomycin resistance protein
NtRootC45_42220	COG4124	Belongs to the glycosyl hydrolase 26 family
NtRootC45_42280	COG1129	ABC transporter
NtRootC45_42290	COG1172	Belongs to the binding-protein-dependent transport system permease family
NtRootC45_42320	COG2826	transposase and inactivated derivatives, IS30 family
NtRootC45_42370	COG0673	inositol 2-dehydrogenase activity
NtRootC45_42410	COG1929	Belongs to the glycerate kinase type-1 family
NtRootC45_42430	COG1204	response to ionizing radiation
NtRootC45_42490	COG4974	Belongs to the 'phage' integrase family
NtRootC45_42590	COG0179	Fumarylacetoacetate (FAA) hydrolase
NtRootC45_42620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate