locus-tag	class	description
KY499_00045	COG1595	DNA-templated transcription, initiation
KY499_00055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KY499_00105	COG1414	Transcriptional regulator
KY499_00110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KY499_00115	COG0066	3-isopropylmalate dehydratase activity
KY499_00125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KY499_00135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KY499_00140	COG1181	Belongs to the D-alanine--D-alanine ligase family
KY499_00175	COG1134	teichoic acid transport
KY499_00185	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KY499_00200	COG0463	Glycosyl transferase, family 2
KY499_00225	COG1216	Glycosyl transferase, family 2
KY499_00330	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KY499_00400	COG0742	ribosomal rna small subunit methyltransferase
KY499_00415	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KY499_00425	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KY499_00430	COG0571	ribonuclease III activity
KY499_00435	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KY499_00460	COG2814	Major facilitator Superfamily
KY499_00475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KY499_00500	COG2514	catechol 2,3-dioxygenase activity
KY499_00515	COG0228	four-way junction DNA binding
KY499_00520	COG1837	Belongs to the UPF0109 family
KY499_00525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KY499_00535	COG0335	large ribosomal subunit rRNA binding
KY499_00540	COG0681	Belongs to the peptidase S26 family
KY499_00550	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KY499_00565	COG0792	nuclease activity
KY499_00580	COG4974	Belongs to the 'phage' integrase family
KY499_00595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KY499_00600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KY499_00655	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KY499_00660	COG1045	serine acetyltransferase
KY499_00670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KY499_00675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KY499_00685	COG3022	response to hydroperoxide
KY499_00720	COG0242	peptide deformylase activity
KY499_00765	COG1302	Protein conserved in bacteria
KY499_00770	COG1595	DNA-templated transcription, initiation
KY499_00800	COG0629	single-stranded DNA binding
KY499_00810	COG1946	Acyl-CoA thioesterase
KY499_00825	COG0668	transmembrane transport
KY499_00845	COG0698	ribose 5-phosphate isomerase
KY499_00865	COG0544	peptidyl-prolyl cis-trans isomerase activity
KY499_00870	COG0740	serine-type endopeptidase activity
KY499_00875	COG0740	serine-type endopeptidase activity
KY499_00880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KY499_00885	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KY499_00910	COG0525	valine-tRNA ligase activity
KY499_00915	COG1115	amino acid carrier protein
KY499_00930	COG0596	Alpha beta hydrolase
KY499_00935	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KY499_00940	COG0285	dihydrofolate synthase activity
KY499_00950	COG0105	UTP biosynthetic process
KY499_00965	COG0352	thiamine-phosphate diphosphorylase activity
KY499_00965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KY499_00965	COG0351	phosphomethylpyrimidine kinase
KY499_00970	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KY499_00975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KY499_00980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KY499_00985	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KY499_01000	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KY499_01010	COG0799	negative regulation of ribosome biogenesis
KY499_01025	COG2824	Alkylphosphonate utilization operon protein PhnA
KY499_01030	COG2813	Specifically methylates the guanine in position
KY499_01040	COG1653	transport
KY499_01045	COG1175	transmembrane transport
KY499_01080	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KY499_01100	COG0583	DNA-binding transcription factor activity
KY499_01115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KY499_01125	COG1780	Probably involved in ribonucleotide reductase function
KY499_01130	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KY499_01135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KY499_01145	COG2161	toxin-antitoxin pair type II binding
KY499_01160	COG2354	Protein conserved in bacteria
KY499_01165	COG3655	Transcriptional regulator
KY499_01175	COG1028	Short-chain dehydrogenase reductase Sdr
KY499_01180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KY499_01200	COG1012	belongs to the aldehyde dehydrogenase family
KY499_01210	COG3192	ethanolamine utilization protein
KY499_01235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KY499_01255	COG0412	Dienelactone hydrolase
KY499_01305	COG3268	Saccharopine dehydrogenase
KY499_01405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KY499_01420	COG2135	peptidase activity
KY499_01430	COG0077	Prephenate dehydratase
KY499_01430	COG1605	Chorismate mutase
KY499_01470	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KY499_01520	COG4585	Histidine kinase
KY499_01535	COG3002	Belongs to the UPF0753 family
KY499_01550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KY499_01555	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KY499_01560	COG0217	transcriptional regulatory protein
KY499_01565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KY499_01570	COG0632	four-way junction helicase activity
KY499_01575	COG2255	four-way junction helicase activity
KY499_01585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KY499_01590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KY499_01595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KY499_01605	COG1196	nuclear chromosome segregation
KY499_01615	COG0124	histidyl-tRNA synthetase
KY499_01625	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KY499_01645	COG0798	PFAM Bile acid sodium symporter
KY499_01650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KY499_01675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KY499_01690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KY499_01695	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KY499_01705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KY499_01710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KY499_01715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KY499_01720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KY499_01730	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KY499_01735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KY499_01745	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KY499_01750	COG0540	Belongs to the ATCase OTCase family
KY499_01755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KY499_01765	COG0505	Belongs to the CarA family
KY499_01770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KY499_01775	COG0284	orotidine-5'-phosphate decarboxylase activity
KY499_01780	COG0194	GDP metabolic process
KY499_01790	COG1758	RNA polymerase activity
KY499_01800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KY499_01815	COG3150	esterase
KY499_01830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KY499_01835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KY499_01840	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KY499_01865	COG0495	leucyl-tRNA aminoacylation
KY499_01870	COG1307	EDD domain protein, DegV family
KY499_01895	COG0268	Binds directly to 16S ribosomal RNA
KY499_01925	COG1420	regulation of RNA biosynthetic process
KY499_01930	COG0484	heat shock protein binding
KY499_01935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KY499_01950	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KY499_01960	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KY499_01965	COG1316	TRANSCRIPTIONal
KY499_01990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KY499_01995	COG3590	peptidase
KY499_02000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KY499_02005	COG1381	Involved in DNA repair and RecF pathway recombination
KY499_02010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KY499_02025	COG0167	dihydroorotate dehydrogenase activity
KY499_02045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KY499_02070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KY499_02075	COG0723	plastoquinol--plastocyanin reductase activity
KY499_02080	COG2010	Cytochrome c
KY499_02085	COG1845	cytochrome c oxidase, subunit III
KY499_02090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KY499_02115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KY499_02120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KY499_02160	COG0745	RESPONSE REGULATOR receiver
KY499_02165	COG2205	protein histidine kinase activity
KY499_02190	COG0009	L-threonylcarbamoyladenylate synthase
KY499_02225	COG0589	response to stress
KY499_02235	COG4176	ABC-type proline glycine betaine transport system permease component
KY499_02240	COG0517	IMP dehydrogenase activity
KY499_02240	COG4175	Glycine betaine
KY499_02295	COG1739	Uncharacterized protein family UPF0029
KY499_02300	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KY499_02300	COG0237	dephospho-CoA kinase activity
KY499_02305	COG0556	nucleotide-excision repair
KY499_02330	COG4106	trans-aconitate 2-methyltransferase activity
KY499_02365	COG0322	excinuclease ABC activity
KY499_02370	COG1660	Displays ATPase and GTPase activities
KY499_02375	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KY499_02380	COG1481	regulation of sporulation
KY499_02385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KY499_02390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KY499_02400	COG0149	triose-phosphate isomerase activity
KY499_02405	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KY499_02415	COG0363	glucosamine-6-phosphate deaminase activity
KY499_02430	COG0166	Belongs to the GPI family
KY499_02435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KY499_02445	COG0109	protoheme IX farnesyltransferase activity
KY499_02450	COG1612	heme a metabolic process
KY499_02460	COG1131	(ABC) transporter
KY499_02485	COG0396	ATPase activity
KY499_02490	COG2151	metal-sulfur cluster biosynthetic enzyme
KY499_02505	COG0318	PFAM AMP-dependent synthetase and ligase
KY499_02520	COG1122	ATPase activity
KY499_02530	COG0488	(ABC) transporter
KY499_02565	COG1028	Short-chain dehydrogenase reductase Sdr
KY499_02570	COG3830	Belongs to the UPF0237 family
KY499_02570	COG0560	Phosphoserine phosphatase
KY499_02575	COG1119	ATPase activity
KY499_02590	COG0254	rRNA binding
KY499_02605	COG2855	membrane
KY499_02610	COG2308	Evidence 4 Homologs of previously reported genes of
KY499_02655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KY499_02675	COG0183	Belongs to the thiolase family
KY499_02680	COG1028	Short-chain dehydrogenase reductase Sdr
KY499_02700	COG0435	Glutathione S-transferase
KY499_02755	COG3511	phospholipase C
KY499_02785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KY499_02810	COG1968	undecaprenyl-diphosphatase activity
KY499_02815	COG0215	cysteine-tRNA ligase activity
KY499_02825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KY499_02830	COG0517	IMP dehydrogenase activity
KY499_02830	COG1994	Peptidase M50
KY499_02840	COG1222	aaa ATPase
KY499_02845	COG4122	O-methyltransferase activity
KY499_02855	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KY499_02860	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KY499_02865	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KY499_02870	COG0545	Peptidyl-prolyl cis-trans isomerase
KY499_02890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KY499_02895	COG0805	protein transport
KY499_02900	COG4581	dead DEAH box helicase
KY499_02905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KY499_02910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KY499_02920	COG1216	Glycosyl transferase, family 2
KY499_02970	COG0242	peptide deformylase activity
KY499_02985	COG3424	synthase
KY499_03010	COG4974	Belongs to the 'phage' integrase family
KY499_03030	COG1266	CAAX protease self-immunity
KY499_03065	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KY499_03080	COG0251	oxidation-reduction process
KY499_03100	COG1012	belongs to the aldehyde dehydrogenase family
KY499_03105	COG0583	DNA-binding transcription factor activity
KY499_03110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KY499_03125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KY499_03130	COG0531	amino acid
KY499_03135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KY499_03140	COG0730	response to heat
KY499_03145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KY499_03150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KY499_03150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KY499_03155	COG2814	Major facilitator Superfamily
KY499_03170	COG1643	Atp-dependent helicase
KY499_03185	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KY499_03200	COG4134	Bacterial extracellular solute-binding protein
KY499_03210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KY499_03230	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KY499_03240	COG3387	PFAM Glycoside hydrolase 15-related
KY499_03250	COG2261	transglycosylase associated protein
KY499_03270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KY499_03330	COG1247	-acetyltransferase
KY499_03360	COG3226	Transcriptional regulator
KY499_03365	COG2207	Transcriptional regulator
KY499_03370	COG3547	Transposase (IS116 IS110 IS902 family)
KY499_03380	COG1012	belongs to the aldehyde dehydrogenase family
KY499_03450	COG0531	amino acid
KY499_03455	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KY499_03480	COG3237	CsbD-like
KY499_03500	COG1802	Transcriptional regulator
KY499_03515	COG3971	2-oxopent-4-enoate hydratase activity
KY499_03525	COG5006	permease, DMT superfamily
KY499_03570	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KY499_03580	COG0590	tRNA wobble adenosine to inosine editing
KY499_03595	COG2132	Multicopper oxidase
KY499_03640	COG2124	cytochrome p450
KY499_03640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KY499_03650	COG1695	Transcriptional regulator
KY499_03655	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KY499_03660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KY499_03670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KY499_03685	COG0577	efflux transmembrane transporter activity
KY499_03685	COG1136	(ABC) transporter
KY499_03700	COG2217	Heavy metal translocating P-type atpase
KY499_03705	COG2217	Heavy metal translocating P-type atpase
KY499_03715	COG0277	FAD linked oxidase domain protein
KY499_03750	COG0569	domain protein
KY499_03755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KY499_03765	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KY499_03900	COG1278	Cold shock
KY499_03935	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KY499_04020	COG1937	Protein conserved in bacteria
KY499_04030	COG3103	Sh3 type 3 domain protein
KY499_04030	COG1388	LysM domain
KY499_04030	COG0791	NLP P60 protein
KY499_04050	COG0785	Cytochrome C biogenesis protein
KY499_04055	COG2132	Multicopper oxidase
KY499_04080	COG1196	nuclear chromosome segregation
KY499_04080	COG0741	lytic transglycosylase activity
KY499_04080	COG0739	heme binding
KY499_04095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KY499_04115	COG0803	Belongs to the bacterial solute-binding protein 9 family
KY499_04115	COG3443	Belongs to the bacterial solute-binding protein 9 family
KY499_04120	COG1121	(ABC) transporter
KY499_04125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KY499_04160	COG2132	Multicopper oxidase
KY499_04185	COG0531	amino acid
KY499_04190	COG2217	Heavy metal translocating P-type atpase
KY499_04195	COG2217	Heavy metal translocating P-type atpase
KY499_04215	COG0469	pyruvate kinase activity
KY499_04225	COG0069	glutamate synthase activity
KY499_04225	COG0070	glutamate synthase
KY499_04225	COG0067	glutamate synthase
KY499_04230	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KY499_04235	COG0159	tryptophan synthase activity
KY499_04240	COG0133	tryptophan synthase activity
KY499_04245	COG0134	indole-3-glycerol-phosphate synthase activity
KY499_04265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KY499_04275	COG0107	imidazoleglycerol-phosphate synthase activity
KY499_04280	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KY499_04285	COG0140	phosphoribosyl-ATP diphosphatase activity
KY499_04290	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KY499_04300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KY499_04300	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KY499_04315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KY499_04325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KY499_04330	COG0242	peptide deformylase activity
KY499_04390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KY499_04435	COG0183	Belongs to the thiolase family
KY499_04440	COG1024	Enoyl-CoA hydratase
KY499_04440	COG1250	3-hydroxyacyl-CoA dehydrogenase
KY499_04445	COG0589	response to stress
KY499_04450	COG0517	IMP dehydrogenase activity
KY499_04470	COG4152	abc transporter atp-binding protein
KY499_04505	COG3845	ABC transporter
KY499_04530	COG0667	Aldo Keto reductase
KY499_04545	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KY499_04555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KY499_04560	COG0531	amino acid
KY499_04590	COG0756	dUTP diphosphatase activity
KY499_04625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KY499_04655	COG4988	ABC transporter
KY499_04660	COG1294	oxidase, subunit
KY499_04665	COG1271	oxidase subunit
KY499_04690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KY499_04710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KY499_04715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KY499_04720	COG0508	dehydrogenase complex catalyzes the overall conversion of
KY499_04730	COG1764	response to oxidative stress
KY499_04740	COG1090	epimerase
KY499_04750	COG0321	lipoyl(octanoyl) transferase activity
KY499_04755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KY499_04790	COG1609	Transcriptional regulator
KY499_04795	COG1129	ABC transporter
KY499_04800	COG1172	Belongs to the binding-protein-dependent transport system permease family
KY499_04810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KY499_04815	COG1869	D-ribose catabolic process
KY499_04830	COG1126	abc transporter atp-binding protein
KY499_04835	COG0765	amino acid transport
KY499_04840	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KY499_04845	COG0174	glutamine synthetase
KY499_04850	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KY499_04870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KY499_04875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KY499_04900	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KY499_04915	COG1799	cell septum assembly
KY499_04930	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KY499_04940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KY499_04945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KY499_04950	COG0772	Belongs to the SEDS family
KY499_04955	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KY499_04960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KY499_04975	COG0768	penicillin binding
KY499_04985	COG0275	rRNA processing
KY499_04990	COG2001	Belongs to the MraZ family
KY499_05000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KY499_05010	COG0142	geranyltranstransferase activity
KY499_05025	COG0515	serine threonine protein kinase
KY499_05025	COG2815	serine threonine protein kinase
KY499_05030	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KY499_05050	COG1940	carbohydrate kinase activity
KY499_05060	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KY499_05090	COG0509	glycine decarboxylation via glycine cleavage system
KY499_05125	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KY499_05130	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KY499_05165	COG2079	MmgE PrpD family protein
KY499_05170	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KY499_05175	COG0563	adenylate kinase activity
KY499_05215	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KY499_05220	COG0400	carboxylic ester hydrolase activity
KY499_05235	COG0494	nUDIX hydrolase
KY499_05240	COG0504	CTP synthase activity
KY499_05250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KY499_05265	COG0647	UMP catabolic process
KY499_05345	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KY499_05355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KY499_05360	COG2094	Belongs to the DNA glycosylase MPG family
KY499_05370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KY499_05370	COG2169	Transcriptional regulator
KY499_05380	COG0259	pyridoxamine-phosphate oxidase activity
KY499_05385	COG0165	Argininosuccinate lyase
KY499_05390	COG0137	argininosuccinate synthase activity
KY499_05395	COG1438	arginine binding
KY499_05400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KY499_05405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KY499_05410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KY499_05415	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KY499_05420	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KY499_05440	COG0072	phenylalanine-tRNA ligase activity
KY499_05440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KY499_05445	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KY499_05450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KY499_05495	COG2814	Major facilitator Superfamily
KY499_05510	COG2261	transglycosylase associated protein
KY499_05515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KY499_05520	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KY499_05525	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KY499_05530	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KY499_05550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KY499_05560	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KY499_05565	COG0131	Imidazoleglycerol-phosphate dehydratase
KY499_05570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KY499_05580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KY499_05590	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KY499_05600	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KY499_05610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KY499_05615	COG2137	regulation of response to DNA damage stimulus
KY499_05620	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KY499_05635	COG1396	sequence-specific DNA binding
KY499_05640	COG1058	Belongs to the CinA family
KY499_05640	COG1546	Belongs to the CinA family
KY499_05655	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KY499_05660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KY499_05690	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KY499_05700	COG0521	Mo-molybdopterin cofactor biosynthetic process
KY499_05725	COG0745	RESPONSE REGULATOR receiver
KY499_05745	COG2807	transmembrane transport
KY499_05750	COG0612	Peptidase, M16
KY499_05755	COG1185	polyribonucleotide nucleotidyltransferase activity
KY499_05760	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KY499_05770	COG3483	tryptophan 2,3-dioxygenase activity
KY499_05815	COG0436	Aminotransferase
KY499_05825	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KY499_05830	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KY499_05845	COG0779	Required for maturation of 30S ribosomal subunits
KY499_05860	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
KY499_05885	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KY499_05905	COG0750	zinc metalloprotease
KY499_05910	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KY499_05945	COG4565	transcriptional regulatory protein
KY499_05970	COG1960	acyl-CoA dehydrogenase activity
KY499_05980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KY499_06000	COG0022	dehydrogenase e1 component
KY499_06010	COG1522	sequence-specific DNA binding
KY499_06015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KY499_06025	COG3275	phosphorelay sensor kinase activity
KY499_06030	COG3279	Response regulator of the LytR AlgR family
KY499_06040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KY499_06050	COG0575	Belongs to the CDS family
KY499_06055	COG0233	cytoplasmic translational termination
KY499_06060	COG0528	UMP kinase activity
KY499_06065	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KY499_06070	COG0052	Belongs to the universal ribosomal protein uS2 family
KY499_06090	COG1953	Uracil, thiamine, allantoin
KY499_06100	COG0297	glycogen (starch) synthase activity
KY499_06110	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KY499_06120	COG2814	Major facilitator Superfamily
KY499_06140	COG0358	DNA primase activity
KY499_06160	COG0277	FAD linked oxidase domain protein
KY499_06185	COG0423	glycine-tRNA ligase activity
KY499_06235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KY499_06240	COG2873	o-acetylhomoserine
KY499_06260	COG1228	amidohydrolase
KY499_06270	COG0156	8-amino-7-oxononanoate synthase activity
KY499_06275	COG1063	alcohol dehydrogenase
KY499_06295	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KY499_06300	COG0251	oxidation-reduction process
KY499_06320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KY499_06325	COG0631	protein serine/threonine phosphatase activity
KY499_06340	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KY499_06340	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KY499_06350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KY499_06365	COG1823	symporter activity
KY499_06375	COG0393	Putative heavy-metal-binding
KY499_06385	COG2409	Drug exporters of the RND superfamily
KY499_06400	COG0424	maF-like protein
KY499_06405	COG4770	biotin carboxylase activity
KY499_06415	COG0477	Major facilitator Superfamily
KY499_06420	COG2223	nitrite transmembrane transporter activity
KY499_06425	COG0243	molybdopterin cofactor binding
KY499_06475	COG1959	2 iron, 2 sulfur cluster binding
KY499_06480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KY499_06510	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KY499_06530	COG0702	epimerase
KY499_06550	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KY499_06555	COG0822	iron-sulfur transferase activity
KY499_06575	COG0489	protein tyrosine kinase activity
KY499_06580	COG0438	transferase activity, transferring glycosyl groups
KY499_06670	COG0193	aminoacyl-tRNA hydrolase activity
KY499_06675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KY499_06685	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KY499_06695	COG0488	(ABC) transporter
KY499_06700	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KY499_06705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KY499_06710	COG3583	domain protein
KY499_06715	COG0084	hydrolase, TatD family'
KY499_06720	COG0714	Associated with various cellular activities
KY499_06765	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KY499_06810	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KY499_06820	COG1316	TRANSCRIPTIONal
KY499_06825	COG1482	cell wall glycoprotein biosynthetic process
KY499_06840	COG1494	fructose-1,6-bisphosphatase
KY499_06850	COG0288	reversible hydration of carbon dioxide
KY499_06855	COG0114	fumarate hydratase activity
KY499_06885	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KY499_06900	COG3142	Participates in the control of copper homeostasis
KY499_06910	COG0363	glucosamine-6-phosphate deaminase activity
KY499_06915	COG0395	ABC-type sugar transport system, permease component
KY499_06920	COG1175	transmembrane transport
KY499_06935	COG1940	carbohydrate kinase activity
KY499_06940	COG1105	Belongs to the carbohydrate kinase PfkB family
KY499_06955	COG1331	Highly conserved protein containing a thioredoxin domain
KY499_06965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KY499_06975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KY499_06995	COG2017	converts alpha-aldose to the beta-anomer
KY499_07000	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KY499_07005	COG0183	Belongs to the thiolase family
KY499_07020	COG0559	Belongs to the binding-protein-dependent transport system permease family
KY499_07055	COG1252	NADH dehydrogenase
KY499_07080	COG0148	phosphopyruvate hydratase activity
KY499_07085	COG3956	TIGRFAM MazG family protein
KY499_07090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KY499_07095	COG0586	Pfam SNARE associated Golgi protein
KY499_07120	COG4603	Belongs to the binding-protein-dependent transport system permease family
KY499_07125	COG3845	ABC transporter
KY499_07130	COG1744	ABC transporter substrate-binding protein PnrA-like
KY499_07135	COG2130	NADP-dependent
KY499_07140	COG1764	response to oxidative stress
KY499_07145	COG1846	Transcriptional regulator
KY499_07170	COG2009	succinate dehydrogenase
KY499_07185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KY499_07205	COG0180	Tryptophanyl-tRNA synthetase
KY499_07225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KY499_07250	COG0531	amino acid
KY499_07280	COG4213	ABC transporter substrate-binding protein
KY499_07290	COG1136	(ABC) transporter
KY499_07325	COG0138	bifunctional purine biosynthesis protein purh
KY499_07330	COG0477	Major facilitator Superfamily
KY499_07360	COG1396	sequence-specific DNA binding
KY499_07365	COG0477	Major facilitator Superfamily
KY499_07375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KY499_07380	COG1024	Enoyl-CoA hydratase
KY499_07390	COG1028	Short-chain dehydrogenase reductase Sdr
KY499_07410	COG2268	Band 7 protein
KY499_07425	COG5001	Diguanylate cyclase
KY499_07425	COG3300	MHYT domain
KY499_07430	COG3300	MHYT domain
KY499_07430	COG5001	Diguanylate cyclase
KY499_07480	COG1278	Cold shock
KY499_07505	COG0640	Transcriptional regulator
KY499_07520	COG3103	Sh3 type 3 domain protein
KY499_07520	COG1388	LysM domain
KY499_07520	COG0791	NLP P60 protein
KY499_07555	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KY499_07565	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KY499_07575	COG0713	ATP synthesis coupled electron transport
KY499_07670	COG2801	Transposase and inactivated derivatives
KY499_07675	COG1063	alcohol dehydrogenase
KY499_07710	COG0419	ATPase involved in DNA repair
KY499_07740	COG1104	cysteine desulfurase activity
KY499_07760	COG0419	ATPase involved in DNA repair
KY499_07800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KY499_07815	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KY499_07845	COG1113	amino acid transport
KY499_07850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KY499_07860	COG0028	Belongs to the TPP enzyme family
KY499_07865	COG2890	protein-(glutamine-N5) methyltransferase activity
KY499_07890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KY499_07910	COG0179	Fumarylacetoacetate (FAA) hydrolase
KY499_07975	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KY499_07985	COG2197	response regulator
KY499_07990	COG1953	Uracil, thiamine, allantoin
KY499_08000	COG2072	flavoprotein involved in K transport
KY499_08025	COG1473	amidohydrolase
KY499_08060	COG3118	belongs to the thioredoxin family
KY499_08065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KY499_08070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KY499_08075	COG1937	Protein conserved in bacteria
KY499_08085	COG2267	carboxylic ester hydrolase activity
KY499_08090	COG0477	Major facilitator Superfamily
KY499_08100	COG1254	Belongs to the acylphosphatase family
KY499_08120	COG3103	Sh3 type 3 domain protein
KY499_08120	COG0366	Alpha amylase catalytic
KY499_08125	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KY499_08155	COG5002	protein histidine kinase activity
KY499_08175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KY499_08215	COG1902	pentaerythritol trinitrate reductase activity
KY499_08245	COG1401	restriction endodeoxyribonuclease activity
KY499_08280	COG0028	Belongs to the TPP enzyme family
KY499_08295	COG1396	sequence-specific DNA binding
KY499_08330	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KY499_08335	COG0673	inositol 2-dehydrogenase activity
KY499_08340	COG0673	inositol 2-dehydrogenase activity
KY499_08350	COG0673	inositol 2-dehydrogenase activity
KY499_08360	COG1172	Belongs to the binding-protein-dependent transport system permease family
KY499_08370	COG2188	Transcriptional regulator
KY499_08375	COG3718	enzyme involved in inositol metabolism
KY499_08380	COG2814	Major facilitator Superfamily
KY499_08390	COG0673	inositol 2-dehydrogenase activity
KY499_08405	COG3962	Belongs to the TPP enzyme family
KY499_08415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KY499_08420	COG1942	4-Oxalocrotonate Tautomerase
KY499_08440	COG0483	inositol monophosphate 1-phosphatase activity
KY499_08480	COG3979	chitinase
KY499_08505	COG3387	PFAM Glycoside hydrolase 15-related
KY499_08515	COG1132	(ABC) transporter
KY499_08520	COG0488	(ABC) transporter
KY499_08540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KY499_08545	COG0765	amino acid transport
KY499_08550	COG1126	abc transporter atp-binding protein
KY499_08560	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KY499_08590	COG0739	heme binding
KY499_08605	COG2814	Major facilitator Superfamily
KY499_08615	COG1278	Cold shock
KY499_08630	COG1061	Type III restriction enzyme res subunit
KY499_08645	COG0745	RESPONSE REGULATOR receiver
KY499_08650	COG2205	protein histidine kinase activity
KY499_08660	COG0328	RNA-DNA hybrid ribonuclease activity
KY499_08665	COG0459	protein refolding
KY499_08670	COG1278	Cold shock
KY499_08685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KY499_08705	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
KY499_08715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KY499_08720	COG0509	glycine decarboxylation via glycine cleavage system
KY499_08725	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KY499_08730	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KY499_08730	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KY499_08740	COG0477	Major facilitator Superfamily
KY499_08745	COG0783	Belongs to the Dps family
KY499_08760	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KY499_08770	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KY499_08775	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KY499_08790	COG1338	Plays a role in the flagellum-specific transport system
KY499_08810	COG1360	Flagellar Motor Protein
KY499_08830	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KY499_08840	COG0791	NLP P60 protein
KY499_08850	COG1157	protein secretion by the type III secretion system
KY499_08860	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KY499_08870	COG1677	Flagellar hook-basal body complex protein FliE
KY499_08880	COG1815	bacterial-type flagellum-dependent cell motility
KY499_08895	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KY499_08915	COG4786	Flagellar basal body rod
KY499_08915	COG1256	bacterial-type flagellum assembly
KY499_08920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KY499_08965	COG3842	ATPase activity
KY499_08975	COG0277	FAD linked oxidase domain protein
KY499_08985	COG1609	Transcriptional regulator
KY499_09025	COG0366	Alpha amylase catalytic
KY499_09055	COG0215	cysteine-tRNA ligase activity
KY499_09065	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KY499_09070	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KY499_09085	COG0745	RESPONSE REGULATOR receiver
KY499_09100	COG0588	phosphoglycerate mutase activity
KY499_09120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KY499_09125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KY499_09200	COG2161	toxin-antitoxin pair type II binding
KY499_09440	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KY499_09480	COG1966	Carbon starvation protein
KY499_09490	COG0604	alcohol dehydrogenase
KY499_09535	COG0514	ATP-dependent DNA helicase (RecQ)
KY499_09555	COG1017	nitric oxide dioxygenase activity
KY499_09555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KY499_09560	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
KY499_09580	COG1511	domain protein
KY499_09585	COG1309	transcriptional regulator
KY499_09600	COG2062	phosphohistidine phosphatase, SixA
KY499_09615	COG0745	RESPONSE REGULATOR receiver
KY499_09620	COG2205	protein histidine kinase activity
KY499_09645	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KY499_09650	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KY499_09655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KY499_09665	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KY499_09670	COG0671	phosphoesterase, PA-phosphatase related
KY499_09700	COG4974	Belongs to the 'phage' integrase family
KY499_09745	COG1002	Type II restriction enzyme, methylase subunits
KY499_09825	COG1201	RNA secondary structure unwinding
KY499_09830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KY499_09835	COG2364	Membrane
KY499_09840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KY499_09845	COG0564	pseudouridine synthase activity
KY499_09850	COG0586	Pfam SNARE associated Golgi protein
KY499_09870	COG0667	Aldo Keto reductase
KY499_09880	COG1960	acyl-CoA dehydrogenase activity
KY499_09905	COG3842	ATPase activity
KY499_09915	COG0671	phosphoesterase, PA-phosphatase related
KY499_09945	COG0343	queuine tRNA-ribosyltransferase activity
KY499_09970	COG0351	phosphomethylpyrimidine kinase
KY499_09980	COG0028	Belongs to the TPP enzyme family
KY499_09995	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KY499_10045	COG0438	transferase activity, transferring glycosyl groups
KY499_10050	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KY499_10055	COG1063	alcohol dehydrogenase
KY499_10060	COG0386	Belongs to the glutathione peroxidase family
KY499_10065	COG0739	heme binding
KY499_10065	COG0741	lytic transglycosylase activity
KY499_10065	COG1196	nuclear chromosome segregation
KY499_10090	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KY499_10110	COG1846	Transcriptional regulator
KY499_10140	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KY499_10145	COG0047	phosphoribosylformylglycinamidine synthase activity
KY499_10150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KY499_10165	COG4762	Protein conserved in bacteria
KY499_10170	COG2315	Protein conserved in bacteria
KY499_10175	COG1832	CoA-binding protein
KY499_10180	COG1116	anion transmembrane transporter activity
KY499_10190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KY499_10210	COG1832	CoA-binding protein
KY499_10215	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KY499_10235	COG0191	fructose-bisphosphate aldolase activity
KY499_10260	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KY499_10270	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KY499_10290	COG0183	Belongs to the thiolase family
KY499_10295	COG0666	response to abiotic stimulus
KY499_10305	COG4585	Histidine kinase
KY499_10310	COG2197	response regulator
KY499_10315	COG0574	Belongs to the PEP-utilizing enzyme family
KY499_10315	COG3848	Pyruvate phosphate dikinase
KY499_10320	COG1278	Cold shock
KY499_10360	COG1012	belongs to the aldehyde dehydrogenase family
KY499_10370	COG1960	acyl-CoA dehydrogenase activity
KY499_10375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KY499_10395	COG1024	Enoyl-CoA hydratase
KY499_10415	COG1609	Transcriptional regulator
KY499_10420	COG0395	ABC-type sugar transport system, permease component
KY499_10425	COG1175	transmembrane transport
KY499_10455	COG1302	Protein conserved in bacteria
KY499_10495	COG0697	spore germination
KY499_10540	COG2252	PERMEase
KY499_10545	COG0010	Belongs to the arginase family
KY499_10560	COG1358	cellular component organization or biogenesis
KY499_10585	COG3853	Toxic anion resistance protein (TelA)
KY499_10640	COG1028	Short-chain dehydrogenase reductase Sdr
KY499_10680	COG2217	Heavy metal translocating P-type atpase
KY499_10685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KY499_10685	COG0574	Belongs to the PEP-utilizing enzyme family
KY499_10695	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KY499_10705	COG4122	O-methyltransferase activity
KY499_10750	COG2733	membrane
KY499_10755	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KY499_10770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KY499_10795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KY499_10795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KY499_10795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KY499_10805	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KY499_10830	COG1028	Short-chain dehydrogenase reductase Sdr
KY499_10860	COG2084	Dehydrogenase
KY499_10875	COG1937	Protein conserved in bacteria
KY499_10880	COG3360	Dodecin
KY499_10885	COG0667	Aldo Keto reductase
KY499_10890	COG2261	transglycosylase associated protein
KY499_10915	COG0306	phosphate transporter
KY499_10920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KY499_10965	COG0515	serine threonine protein kinase
KY499_10965	COG2815	serine threonine protein kinase
KY499_10970	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KY499_10975	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
KY499_11000	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
KY499_11005	COG1461	Dihydroxyacetone kinase
KY499_11010	COG2376	Dihydroxyacetone kinase
KY499_11015	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KY499_11020	COG0823	Involved in the tonB-independent uptake of proteins
KY499_11020	COG1506	peptidase
KY499_11050	COG1435	thymidine kinase activity
KY499_11060	COG2814	Major facilitator Superfamily
KY499_11065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KY499_11095	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KY499_11100	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KY499_11105	COG0302	gtp cyclohydrolase
KY499_11110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KY499_11120	COG0037	tRNA processing
KY499_11150	COG0561	phosphatase activity
KY499_11155	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KY499_11160	COG1597	lipid kinase activity
KY499_11175	COG0425	Belongs to the sulfur carrier protein TusA family
KY499_11175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KY499_11180	COG0154	amidase activity
KY499_11195	COG3104	oligopeptide transport
KY499_11210	COG3706	GGDEF domain
KY499_11220	COG0778	Nitroreductase
KY499_11225	COG2233	PERMEase
KY499_11235	COG1028	Short-chain dehydrogenase reductase Sdr
KY499_11245	COG1929	Belongs to the glycerate kinase type-1 family
KY499_11250	COG0584	glycerophosphoryl diester phosphodiesterase
KY499_11260	COG0561	phosphatase activity
KY499_11270	COG1295	ribonuclease BN
KY499_11300	COG5416	Lipopolysaccharide assembly protein A domain
KY499_11305	COG0671	phosphoesterase, PA-phosphatase related
KY499_11325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KY499_11345	COG0789	Transcriptional regulator
KY499_11355	COG1473	amidohydrolase
KY499_11360	COG1802	Transcriptional regulator
KY499_11380	COG0765	amino acid transport
KY499_11400	COG0402	S-adenosylhomocysteine deaminase activity
KY499_11430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KY499_11440	COG1802	Transcriptional regulator
KY499_11450	COG3608	succinylglutamate desuccinylase aspartoacylase
KY499_11465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KY499_11470	COG1929	Belongs to the glycerate kinase type-1 family
KY499_11475	COG3960	tartronate-semialdehyde synthase activity
KY499_11480	COG2084	Dehydrogenase
KY499_11485	COG3622	Belongs to the hyi family
KY499_11490	COG3257	ureidoglycine aminohydrolase activity
KY499_11500	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KY499_11555	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KY499_11575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KY499_11590	COG0477	Major facilitator Superfamily
KY499_11630	COG1028	Short-chain dehydrogenase reductase Sdr
KY499_11650	COG1953	Uracil, thiamine, allantoin
KY499_11660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KY499_11685	COG1914	H( )-stimulated, divalent metal cation uptake system
KY499_11690	COG4336	lyase activity
KY499_11705	COG4770	biotin carboxylase activity
KY499_11715	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KY499_11735	COG1742	UPF0060 membrane protein
KY499_11780	COG1716	ATPase activity
KY499_11785	COG1716	ATPase activity
KY499_11805	COG0515	serine threonine protein kinase
KY499_11825	COG2818	Glycosylase
KY499_11845	COG1215	transferase activity, transferring glycosyl groups
KY499_11870	COG3266	domain, Protein
KY499_11885	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
KY499_11890	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KY499_11895	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KY499_11900	COG0592	DNA-directed DNA polymerase activity
KY499_11910	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KY499_11915	COG0594	ribonuclease P activity
KY499_11920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KY499_11935	COG0357	Ribosomal RNA small subunit methyltransferase G
KY499_11940	COG1192	Involved in chromosome partitioning
KY499_11950	COG3547	Transposase (IS116 IS110 IS902 family)
KY499_11970	COG3118	belongs to the thioredoxin family
KY499_11975	COG0492	ferredoxin-NADP+ reductase activity
KY499_11995	COG0617	tRNA 3'-terminal CCA addition
KY499_12000	COG0406	alpha-ribazole phosphatase activity
KY499_12015	COG0768	penicillin binding
KY499_12020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KY499_12050	COG0738	Major facilitator superfamily
KY499_12060	COG1131	(ABC) transporter
KY499_12070	COG1362	aminopeptidase activity
KY499_12075	COG0360	Binds together with S18 to 16S ribosomal RNA
KY499_12085	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KY499_12090	COG0359	binds to the 23S rRNA
KY499_12115	COG0305	Participates in initiation and elongation during chromosome replication
KY499_12125	COG2259	Doxx family
KY499_12130	COG0534	Mate efflux family protein
KY499_12165	COG1937	Protein conserved in bacteria
KY499_12185	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KY499_12210	COG1597	lipid kinase activity
KY499_12230	COG1607	acyl-coa hydrolase
KY499_12245	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KY499_12260	COG1950	PFAM Membrane protein of
KY499_12265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KY499_12275	COG0022	dehydrogenase e1 component
KY499_12280	COG0508	dehydrogenase complex catalyzes the overall conversion of
KY499_12285	COG0318	PFAM AMP-dependent synthetase and ligase
KY499_12295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KY499_12320	COG0673	inositol 2-dehydrogenase activity
KY499_12325	COG0686	Belongs to the AlaDH PNT family
KY499_12345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KY499_12360	COG0246	Mannitol dehydrogenase
KY499_12365	COG0477	Major facilitator Superfamily
KY499_12375	COG1309	transcriptional regulator
KY499_12400	COG1522	sequence-specific DNA binding
KY499_12430	COG1027	Aspartate ammonia-lyase
KY499_12440	COG2186	Transcriptional regulator
KY499_12445	COG0039	L-malate dehydrogenase activity
KY499_12480	COG3300	MHYT domain
KY499_12480	COG5001	Diguanylate cyclase
KY499_12490	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KY499_12520	COG0667	Aldo Keto reductase
KY499_12530	COG3012	SEC-C Motif Domain Protein
KY499_12580	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KY499_12580	COG2066	Belongs to the glutaminase family
KY499_12605	COG2723	6-phospho-beta-galactosidase activity
KY499_12625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KY499_12630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KY499_12635	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KY499_12655	COG1609	Transcriptional regulator
KY499_12680	COG0776	regulation of translation
KY499_12685	COG3336	cytochrome c oxidase
KY499_12715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY499_12730	COG1349	DNA-binding transcription factor activity
KY499_12735	COG0395	ABC-type sugar transport system, permease component
KY499_12755	COG3387	PFAM Glycoside hydrolase 15-related
KY499_12765	COG3547	Transposase (IS116 IS110 IS902 family)
KY499_12775	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KY499_12780	COG0583	DNA-binding transcription factor activity
KY499_12785	COG1012	belongs to the aldehyde dehydrogenase family
KY499_12820	COG0717	Belongs to the dCTP deaminase family
KY499_12840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KY499_12840	COG2111	Na H antiporter
KY499_12845	COG1006	Multisubunit Na H antiporter MnhC subunit
KY499_12850	COG0651	ATP synthesis coupled electron transport
KY499_12860	COG2212	antiporter activity
KY499_12865	COG1320	monovalent cation:proton antiporter activity
KY499_12875	COG4721	ABC-type cobalt transport system, permease component
KY499_12880	COG1122	ATPase activity
KY499_12890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KY499_12895	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KY499_12935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KY499_12940	COG1280	lysine exporter protein (LysE YggA)
KY499_12965	COG0443	Heat shock 70 kDa protein
KY499_12970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KY499_12975	COG0484	heat shock protein binding
KY499_12980	COG0789	Transcriptional regulator
KY499_12985	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KY499_12990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KY499_13020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KY499_13025	COG2807	transmembrane transport
KY499_13040	COG3547	Transposase (IS116 IS110 IS902 family)
KY499_13070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KY499_13080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KY499_13105	COG0667	Aldo Keto reductase
KY499_13125	COG0135	phosphoribosylanthranilate isomerase activity
KY499_13195	COG3585	molybdate ion transport
KY499_13215	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KY499_13240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KY499_13255	COG2226	methyltransferase
KY499_13275	COG2267	carboxylic ester hydrolase activity
KY499_13305	COG1132	(ABC) transporter
KY499_13315	COG0438	transferase activity, transferring glycosyl groups
KY499_13325	COG5002	protein histidine kinase activity
KY499_13330	COG0745	RESPONSE REGULATOR receiver
KY499_13340	COG3118	belongs to the thioredoxin family
KY499_13345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KY499_13370	COG2199	diguanylate cyclase activity
KY499_13370	COG2200	EAL domain
KY499_13380	COG0784	Response regulator, receiver
KY499_13380	COG4191	Histidine kinase
KY499_13400	COG1410	methionine synthase
KY499_13400	COG0646	methionine synthase
KY499_13430	COG2197	response regulator
KY499_13440	COG0406	alpha-ribazole phosphatase activity
KY499_13445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KY499_13450	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
KY499_13475	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KY499_13525	COG2267	carboxylic ester hydrolase activity
KY499_13555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KY499_13560	COG2267	carboxylic ester hydrolase activity
KY499_13565	COG0006	proline dipeptidase activity
KY499_13590	COG0583	DNA-binding transcription factor activity
KY499_13595	COG0251	oxidation-reduction process
KY499_13605	COG0765	amino acid transport
KY499_13610	COG1126	abc transporter atp-binding protein
KY499_13630	COG1263	PTS System
KY499_13630	COG2190	(PTS) system
KY499_13630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KY499_13635	COG2190	(PTS) system
KY499_13645	COG3711	transcriptional antiterminator
KY499_13650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KY499_13655	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KY499_13665	COG2986	histidine ammonia-lyase
KY499_13675	COG2124	cytochrome p450
KY499_13685	COG0318	PFAM AMP-dependent synthetase and ligase
KY499_13695	COG0673	inositol 2-dehydrogenase activity
KY499_13705	COG1172	Belongs to the binding-protein-dependent transport system permease family
KY499_13715	COG1609	Transcriptional regulator
KY499_13720	COG1082	Xylose isomerase domain protein TIM barrel
KY499_13735	COG3718	enzyme involved in inositol metabolism
KY499_13745	COG3962	Belongs to the TPP enzyme family
KY499_13855	COG2197	response regulator
KY499_13865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KY499_13870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KY499_13875	COG0698	ribose 5-phosphate isomerase
KY499_13890	COG0531	amino acid
KY499_13930	COG0363	glucosamine-6-phosphate deaminase activity
KY499_13935	COG1228	amidohydrolase
KY499_13940	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
KY499_13945	COG1940	carbohydrate kinase activity
KY499_13950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KY499_13960	COG0444	Belongs to the ABC transporter superfamily
KY499_13965	COG0601	transmembrane transport
KY499_13970	COG0747	negative chemotaxis
KY499_14020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KY499_14025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY499_14045	COG0531	amino acid
KY499_14065	COG0589	response to stress
KY499_14075	COG0667	Aldo Keto reductase
KY499_14100	COG0789	Transcriptional regulator
KY499_14105	COG0071	Belongs to the small heat shock protein (HSP20) family
KY499_14130	COG3387	PFAM Glycoside hydrolase 15-related
KY499_14160	COG0151	Belongs to the GarS family
KY499_14165	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KY499_14185	COG1132	(ABC) transporter
KY499_14190	COG1132	(ABC) transporter
KY499_14195	COG1408	metallophosphoesterase
KY499_14200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KY499_14235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KY499_14265	COG1051	belongs to the nudix hydrolase family
KY499_14275	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KY499_14275	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KY499_14330	COG1054	Belongs to the UPF0176 family
KY499_14345	COG2890	protein-(glutamine-N5) methyltransferase activity
KY499_14355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KY499_14355	COG1754	DNA topoisomerase type I activity
KY499_14365	COG0248	Ppx GppA phosphatase
KY499_14375	COG0569	domain protein
KY499_14380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KY499_14385	COG0123	including yeast histone deacetylase and acetoin utilization protein
KY499_14425	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KY499_14445	COG0406	alpha-ribazole phosphatase activity
KY499_14450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KY499_14455	COG0785	Cytochrome C biogenesis protein
KY499_14495	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KY499_14510	COG1121	(ABC) transporter
KY499_14515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KY499_14530	COG3237	CsbD-like
KY499_14550	COG1024	Enoyl-CoA hydratase
KY499_14555	COG1250	3-hydroxyacyl-CoA dehydrogenase
KY499_14585	COG2050	protein possibly involved in aromatic compounds catabolism
KY499_14590	COG1012	belongs to the aldehyde dehydrogenase family
KY499_14590	COG2030	dehydratase
KY499_14620	COG2050	protein possibly involved in aromatic compounds catabolism
KY499_14635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KY499_14640	COG3848	Pyruvate phosphate dikinase
KY499_14640	COG0574	Belongs to the PEP-utilizing enzyme family
KY499_14660	COG1316	TRANSCRIPTIONal
KY499_14670	COG3396	Phenylacetate-CoA oxygenase
KY499_14675	COG3460	Phenylacetate-CoA oxygenase
KY499_14680	COG3396	Phenylacetate-CoA oxygenase
KY499_14685	COG2151	metal-sulfur cluster biosynthetic enzyme
KY499_14690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KY499_14695	COG1024	Enoyl-CoA hydratase
KY499_14725	COG0508	dehydrogenase complex catalyzes the overall conversion of
KY499_14730	COG2017	converts alpha-aldose to the beta-anomer
KY499_14750	COG1070	Carbohydrate kinase
KY499_14770	COG2378	regulation of single-species biofilm formation
KY499_14800	COG1175	transmembrane transport
KY499_14805	COG1653	transport
KY499_14835	COG0698	ribose 5-phosphate isomerase
KY499_14840	COG1250	3-hydroxyacyl-CoA dehydrogenase
KY499_14845	COG1028	Short-chain dehydrogenase reductase Sdr
KY499_14850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KY499_14860	COG0149	triose-phosphate isomerase activity
KY499_14900	COG4948	Mandelate Racemase Muconate Lactonizing
KY499_14915	COG0018	arginyl-trna synthetase
KY499_14920	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KY499_14930	COG1126	abc transporter atp-binding protein
KY499_14935	COG0765	amino acid transport
KY499_14945	COG1169	isochorismate synthase
KY499_14950	COG2226	methyltransferase
KY499_14960	COG0142	geranyltranstransferase activity
KY499_14970	COG2860	membrane
KY499_14985	COG0175	sulfate reduction
KY499_15015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KY499_15025	COG1648	precorrin-2 dehydrogenase activity
KY499_15025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KY499_15055	COG2186	Transcriptional regulator
KY499_15070	COG1012	belongs to the aldehyde dehydrogenase family
KY499_15080	COG2826	transposase and inactivated derivatives, IS30 family
KY499_15125	COG0531	amino acid
KY499_15145	COG0501	Belongs to the peptidase M48B family
KY499_15155	COG1666	GTP binding
KY499_15205	COG1131	(ABC) transporter
KY499_15210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KY499_15220	COG0318	PFAM AMP-dependent synthetase and ligase
KY499_15245	COG1051	belongs to the nudix hydrolase family
KY499_15285	COG1940	carbohydrate kinase activity
KY499_15290	COG0366	Alpha amylase catalytic
KY499_15295	COG4989	oxidoreductase activity
KY499_15310	COG0659	secondary active sulfate transmembrane transporter activity
KY499_15320	COG2030	dehydratase
KY499_15330	COG0738	Major facilitator superfamily
KY499_15345	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KY499_15360	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KY499_15370	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KY499_15375	COG0456	acetyltransferase
KY499_15390	COG3485	protocatechuate 3,4-dioxygenase
KY499_15400	COG0354	folic acid binding
KY499_15450	COG0436	Aminotransferase
KY499_15470	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KY499_15475	COG0081	regulation of translation
KY499_15485	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KY499_15490	COG0222	ribosome binding
KY499_15495	COG0442	prolyl-tRNA aminoacylation
KY499_15505	COG0085	RNA polymerase activity
KY499_15515	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KY499_15520	COG0049	tRNA binding
KY499_15525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KY499_15530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KY499_15540	COG0051	transcription antitermination factor activity, RNA binding
KY499_15545	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KY499_15550	COG0088	Forms part of the polypeptide exit tunnel
KY499_15555	COG0089	rRNA binding
KY499_15565	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KY499_15570	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KY499_15575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KY499_15580	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KY499_15585	COG0255	Belongs to the universal ribosomal protein uL29 family
KY499_15590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KY499_15595	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KY499_15600	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KY499_15605	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KY499_15610	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KY499_15615	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KY499_15625	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KY499_15630	COG1841	ribosomal large subunit assembly
KY499_15635	COG0200	Binds to the 23S rRNA
KY499_15645	COG0563	adenylate kinase activity
KY499_15655	COG3191	aminopeptidase activity
KY499_15660	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KY499_15665	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KY499_15670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KY499_15675	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KY499_15680	COG0202	RNA polymerase activity
KY499_15685	COG0203	ribosomal protein L17
KY499_15695	COG0745	RESPONSE REGULATOR receiver
KY499_15695	COG2205	protein histidine kinase activity
KY499_15695	COG4191	Histidine kinase
KY499_15700	COG0745	RESPONSE REGULATOR receiver
KY499_15735	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KY499_15740	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KY499_15745	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KY499_15750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KY499_15755	COG1970	mechanosensitive ion channel activity
KY499_15760	COG1876	peptidase activity
KY499_15765	COG1072	(Pantothenic acid kinase))
KY499_15770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KY499_15775	COG0736	holo-[acyl-carrier-protein] synthase activity
KY499_15805	COG1260	myo-inositol-1-phosphate synthase
KY499_15825	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KY499_15830	COG0438	transferase activity, transferring glycosyl groups
KY499_15840	COG1486	melibiose metabolic process
KY499_15850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KY499_15855	COG0802	atpase or kinase
KY499_15870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KY499_15885	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KY499_15895	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KY499_15905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KY499_15910	COG0459	protein refolding
KY499_15915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KY499_15915	COG2755	lipolytic protein G-D-S-L family
KY499_15925	COG1404	Belongs to the peptidase S8 family
KY499_15930	COG0516	GMP reductase activity
KY499_15935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KY499_15955	COG0519	Catalyzes the synthesis of GMP from XMP
KY499_15955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KY499_15960	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KY499_15980	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KY499_16000	COG0561	phosphatase activity
KY499_16015	COG2226	methyltransferase
KY499_16070	COG1205	dead DEAH box helicase
KY499_16070	COG1111	helicase
KY499_16075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KY499_16080	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KY499_16090	COG1401	restriction endodeoxyribonuclease activity
KY499_16180	COG0488	(ABC) transporter
KY499_16200	COG0598	Magnesium transport protein CorA
KY499_16225	COG2971	BadF BadG BcrA BcrD
KY499_16245	COG1174	glycine betaine transport
KY499_16250	COG1174	glycine betaine transport
KY499_16265	COG2326	polyphosphate kinase activity
KY499_16270	COG1722	exodeoxyribonuclease VII activity
KY499_16275	COG1570	exodeoxyribonuclease VII activity
KY499_16290	COG1322	Protein conserved in bacteria
KY499_16295	COG0012	GTP binding
KY499_16305	COG0747	negative chemotaxis
KY499_16310	COG0601	transmembrane transport
KY499_16345	COG3547	Transposase (IS116 IS110 IS902 family)
KY499_16370	COG3226	Transcriptional regulator
KY499_16385	COG2171	N-acyltransferase activity
KY499_16390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KY499_16395	COG0765	amino acid transport
KY499_16400	COG0765	amino acid transport
KY499_16405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KY499_16410	COG1126	abc transporter atp-binding protein
KY499_16440	COG1595	DNA-templated transcription, initiation
KY499_16450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KY499_16465	COG2239	Acts as a magnesium transporter
KY499_16475	COG0006	proline dipeptidase activity
KY499_16480	COG0613	PHP domain protein
KY499_16485	COG2189	Belongs to the N(4) N(6)-methyltransferase family
KY499_16490	COG0513	Belongs to the DEAD box helicase family
KY499_16500	COG0352	thiamine-phosphate diphosphorylase activity
KY499_16505	COG2022	thiamine diphosphate biosynthetic process
KY499_16505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KY499_16515	COG2022	thiamine diphosphate biosynthetic process
KY499_16520	COG2154	pterin-4-alpha-carbinolamine dehydratase
KY499_16545	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KY499_16550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KY499_16560	COG3253	May function as heme-dependent peroxidase
KY499_16565	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KY499_16580	COG0113	porphobilinogen synthase activity
KY499_16585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY499_16590	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KY499_16595	COG1126	abc transporter atp-binding protein
KY499_16600	COG0765	amino acid transport
KY499_16605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KY499_16655	COG3480	Lon protease (S16) C-terminal proteolytic domain
KY499_16680	COG1842	Phage shock protein A
KY499_16690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KY499_16695	COG2086	electron transfer activity
KY499_16700	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KY499_16705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KY499_16720	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KY499_16725	COG0484	heat shock protein binding
KY499_16750	COG0482	sulfurtransferase activity
KY499_16800	COG5002	protein histidine kinase activity
KY499_16805	COG5401	PFAM Sporulation and spore germination
KY499_16815	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KY499_16880	COG1674	ftsk spoiiie
KY499_16940	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KY499_16965	COG1216	Glycosyl transferase, family 2
KY499_16985	COG1088	dTDP-glucose 4,6-dehydratase activity
KY499_17155	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KY499_17160	COG2884	Cell division ATP-binding protein ftsE
KY499_17170	COG0739	heme binding
KY499_17175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KY499_17190	COG0730	response to heat
KY499_17195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KY499_17200	COG1937	Protein conserved in bacteria
KY499_17215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KY499_17220	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KY499_17240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KY499_17245	COG0483	inositol monophosphate 1-phosphatase activity
KY499_17255	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KY499_17265	COG1595	DNA-templated transcription, initiation
KY499_17315	COG1121	(ABC) transporter
KY499_17330	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KY499_17335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KY499_17345	COG2197	response regulator
KY499_17350	COG4585	Histidine kinase
KY499_17360	COG1136	(ABC) transporter
KY499_17360	COG0577	efflux transmembrane transporter activity
KY499_17365	COG1064	alcohol dehydrogenase
KY499_17370	COG0537	adenosine 5'-monophosphoramidase activity
KY499_17375	COG1643	Atp-dependent helicase
KY499_17420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KY499_17420	COG1017	nitric oxide dioxygenase activity
KY499_17435	COG0018	arginyl-trna synthetase
KY499_17440	COG0019	diaminopimelate decarboxylase activity
KY499_17445	COG0460	homoserine dehydrogenase
KY499_17450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KY499_17455	COG0083	homoserine kinase activity
KY499_17465	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KY499_17470	COG2890	protein-(glutamine-N5) methyltransferase activity
KY499_17475	COG0009	L-threonylcarbamoyladenylate synthase
KY499_17480	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KY499_17485	COG1216	Glycosyl transferase, family 2
KY499_17505	COG0356	it plays a direct role in the translocation of protons across the membrane
KY499_17510	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KY499_17515	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KY499_17520	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KY499_17525	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KY499_17530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KY499_17535	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KY499_17540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KY499_17555	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KY499_17565	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
KY499_17580	COG0628	permease
KY499_17595	COG1902	pentaerythritol trinitrate reductase activity
KY499_17610	COG0363	glucosamine-6-phosphate deaminase activity
KY499_17630	COG1473	amidohydrolase
KY499_17635	COG0477	Major facilitator Superfamily
KY499_17645	COG1335	isochorismatase
KY499_17655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KY499_17665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KY499_17670	COG1234	tRNA 3'-trailer cleavage
KY499_17675	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KY499_17685	COG0586	Pfam SNARE associated Golgi protein
KY499_17705	COG2149	membrane
KY499_17715	COG0420	3'-5' exonuclease activity
KY499_17720	COG0419	ATPase involved in DNA repair
KY499_17755	COG0508	dehydrogenase complex catalyzes the overall conversion of
KY499_17760	COG0022	dehydrogenase e1 component
KY499_17775	COG1113	amino acid transport
KY499_17795	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KY499_17805	COG1104	cysteine desulfurase activity
KY499_17830	COG1305	Transglutaminase-like
KY499_17845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KY499_17850	COG0579	oxidoreductase
KY499_17855	COG0747	negative chemotaxis
KY499_17900	COG0129	dihydroxy-acid dehydratase activity
KY499_17910	COG0440	acetolactate synthase activity
KY499_17915	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KY499_17940	COG0473	3-isopropylmalate dehydrogenase activity