locus-tag	class	description
E5206_00010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E5206_00015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E5206_00035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5206_00050	COG2814	Major facilitator Superfamily
E5206_00070	COG4176	ABC-type proline glycine betaine transport system permease component
E5206_00075	COG0517	IMP dehydrogenase activity
E5206_00075	COG4175	Glycine betaine
E5206_00105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5206_00115	COG1414	Transcriptional regulator
E5206_00140	COG0477	Major facilitator Superfamily
E5206_00170	COG0656	L-ascorbic acid biosynthetic process
E5206_00190	COG1966	Carbon starvation protein
E5206_00200	COG0604	alcohol dehydrogenase
E5206_00230	COG0463	Glycosyl transferase, family 2
E5206_00245	COG1505	serine-type exopeptidase activity
E5206_00265	COG0514	ATP-dependent DNA helicase (RecQ)
E5206_00270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5206_00285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5206_00285	COG1017	nitric oxide dioxygenase activity
E5206_00290	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E5206_00300	COG2188	Transcriptional regulator
E5206_00315	COG1511	domain protein
E5206_00320	COG1309	transcriptional regulator
E5206_00335	COG2062	phosphohistidine phosphatase, SixA
E5206_00355	COG0745	RESPONSE REGULATOR receiver
E5206_00360	COG2205	protein histidine kinase activity
E5206_00375	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E5206_00375	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E5206_00380	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E5206_00395	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E5206_00400	COG0671	phosphoesterase, PA-phosphatase related
E5206_00405	COG0590	tRNA wobble adenosine to inosine editing
E5206_00415	COG0438	transferase activity, transferring glycosyl groups
E5206_00450	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E5206_00470	COG0698	ribose 5-phosphate isomerase
E5206_00475	COG2376	Dihydroxyacetone kinase
E5206_00480	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_00495	COG3959	Transketolase, thiamine diphosphate binding domain
E5206_00500	COG3958	Transketolase
E5206_00515	COG0577	efflux transmembrane transporter activity
E5206_00515	COG1136	(ABC) transporter
E5206_00520	COG0577	efflux transmembrane transporter activity
E5206_00520	COG1136	(ABC) transporter
E5206_00545	COG1201	RNA secondary structure unwinding
E5206_00550	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E5206_00555	COG2364	Membrane
E5206_00575	COG0564	pseudouridine synthase activity
E5206_00580	COG0586	Pfam SNARE associated Golgi protein
E5206_00590	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E5206_00620	COG1960	acyl-CoA dehydrogenase activity
E5206_00645	COG3842	ATPase activity
E5206_00690	COG0343	queuine tRNA-ribosyltransferase activity
E5206_00710	COG0028	Belongs to the TPP enzyme family
E5206_00720	COG1396	sequence-specific DNA binding
E5206_00775	COG0438	transferase activity, transferring glycosyl groups
E5206_00780	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E5206_00785	COG1063	alcohol dehydrogenase
E5206_00790	COG0386	Belongs to the glutathione peroxidase family
E5206_00795	COG1196	nuclear chromosome segregation
E5206_00795	COG0741	lytic transglycosylase activity
E5206_00795	COG0739	heme binding
E5206_00820	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5206_00840	COG1846	Transcriptional regulator
E5206_00875	COG0047	phosphoribosylformylglycinamidine synthase activity
E5206_00880	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5206_00900	COG4762	Protein conserved in bacteria
E5206_00905	COG2315	Protein conserved in bacteria
E5206_00915	COG1832	CoA-binding protein
E5206_00925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5206_00940	COG1832	CoA-binding protein
E5206_00960	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E5206_00965	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5206_00980	COG0191	fructose-bisphosphate aldolase activity
E5206_00985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5206_00985	COG0357	Ribosomal RNA small subunit methyltransferase G
E5206_01010	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E5206_01015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5206_01020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E5206_01025	COG0022	dehydrogenase e1 component
E5206_01025	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5206_01030	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5206_01050	COG4948	Mandelate Racemase Muconate Lactonizing
E5206_01060	COG3250	beta-galactosidase activity
E5206_01065	COG0246	Mannitol dehydrogenase
E5206_01070	COG1904	glucuronate isomerase
E5206_01075	COG1609	Transcriptional regulator
E5206_01080	COG0673	inositol 2-dehydrogenase activity
E5206_01095	COG0444	Belongs to the ABC transporter superfamily
E5206_01110	COG0673	inositol 2-dehydrogenase activity
E5206_01120	COG1609	Transcriptional regulator
E5206_01125	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5206_01150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5206_01165	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
E5206_01170	COG0145	ligase activity
E5206_01175	COG4647	ligase activity
E5206_01180	COG0145	ligase activity
E5206_01185	COG1024	Enoyl-CoA hydratase
E5206_01185	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5206_01190	COG1063	alcohol dehydrogenase
E5206_01200	COG3848	Pyruvate phosphate dikinase
E5206_01200	COG0574	Belongs to the PEP-utilizing enzyme family
E5206_01220	COG1278	Cold shock
E5206_01235	COG1960	acyl-CoA dehydrogenase activity
E5206_01240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5206_01255	COG1024	Enoyl-CoA hydratase
E5206_01285	COG1609	Transcriptional regulator
E5206_01305	COG2182	Extracellular solute-binding protein
E5206_01330	COG1302	Protein conserved in bacteria
E5206_01365	COG0583	DNA-binding transcription factor activity
E5206_01370	COG0697	spore germination
E5206_01405	COG0574	Belongs to the PEP-utilizing enzyme family
E5206_01405	COG3848	Pyruvate phosphate dikinase
E5206_01425	COG2252	PERMEase
E5206_01430	COG0010	Belongs to the arginase family
E5206_01440	COG1358	cellular component organization or biogenesis
E5206_01465	COG3853	Toxic anion resistance protein (TelA)
E5206_01500	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E5206_01520	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_01530	COG0583	DNA-binding transcription factor activity
E5206_01555	COG1295	ribonuclease BN
E5206_01585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5206_01585	COG0574	Belongs to the PEP-utilizing enzyme family
E5206_01630	COG2733	membrane
E5206_01650	COG1140	nitrate reductase beta subunit
E5206_01660	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E5206_01680	COG0701	Predicted permease
E5206_01715	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5206_01735	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E5206_01770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5206_01780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5206_01800	COG1349	DNA-binding transcription factor activity
E5206_01810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5206_01810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5206_01810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5206_01820	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E5206_01830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5206_01835	COG0477	Major facilitator Superfamily
E5206_01840	COG1957	nucleoside hydrolase
E5206_01860	COG0477	Major facilitator Superfamily
E5206_01870	COG4221	oxidoreductase activity
E5206_01885	COG0191	fructose-bisphosphate aldolase activity
E5206_01890	COG2610	gluconate transmembrane transporter activity
E5206_01895	COG2084	Dehydrogenase
E5206_01905	COG2186	Transcriptional regulator
E5206_01910	COG1937	Protein conserved in bacteria
E5206_01920	COG3360	Dodecin
E5206_01925	COG0667	Aldo Keto reductase
E5206_01930	COG2261	transglycosylase associated protein
E5206_01940	COG3706	GGDEF domain
E5206_01960	COG0306	phosphate transporter
E5206_01965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5206_02010	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E5206_02015	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
E5206_02040	COG1414	Transcriptional regulator
E5206_02070	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E5206_02075	COG1461	Dihydroxyacetone kinase
E5206_02080	COG2376	Dihydroxyacetone kinase
E5206_02085	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E5206_02090	COG0542	response to heat
E5206_02105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E5206_02120	COG2814	Major facilitator Superfamily
E5206_02125	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E5206_02155	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E5206_02160	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E5206_02165	COG0302	gtp cyclohydrolase
E5206_02170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5206_02180	COG0037	tRNA processing
E5206_02205	COG0561	phosphatase activity
E5206_02210	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5206_02215	COG1597	lipid kinase activity
E5206_02230	COG0425	Belongs to the sulfur carrier protein TusA family
E5206_02230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5206_02235	COG0154	amidase activity
E5206_02240	COG3135	benzoate transporter
E5206_02245	COG3485	protocatechuate 3,4-dioxygenase
E5206_02250	COG4638	Rieske (2fe-2S)
E5206_02255	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E5206_02285	COG0583	DNA-binding transcription factor activity
E5206_02290	COG2814	Major facilitator Superfamily
E5206_02305	COG3104	oligopeptide transport
E5206_02325	COG2066	Belongs to the glutaminase family
E5206_02340	COG3706	GGDEF domain
E5206_02350	COG0778	Nitroreductase
E5206_02355	COG2233	PERMEase
E5206_02365	COG2814	Major facilitator Superfamily
E5206_02375	COG1929	Belongs to the glycerate kinase type-1 family
E5206_02380	COG0584	glycerophosphoryl diester phosphodiesterase
E5206_02390	COG0561	phosphatase activity
E5206_02425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5206_02425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5206_02430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E5206_02460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5206_02465	COG1309	transcriptional regulator
E5206_02475	COG0385	Bile acid
E5206_02480	COG1609	Transcriptional regulator
E5206_02510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5206_02525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5206_02580	COG0574	Belongs to the PEP-utilizing enzyme family
E5206_02580	COG3848	Pyruvate phosphate dikinase
E5206_02585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5206_02585	COG0574	Belongs to the PEP-utilizing enzyme family
E5206_02595	COG1414	Transcriptional regulator
E5206_02600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5206_02610	COG4770	biotin carboxylase activity
E5206_02615	COG1984	allophanate hydrolase subunit 2
E5206_02620	COG0477	Major facilitator Superfamily
E5206_02625	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E5206_02635	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5206_02635	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5206_02640	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E5206_02645	COG0509	glycine decarboxylation via glycine cleavage system
E5206_02650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5206_02660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5206_02670	COG1113	amino acid transport
E5206_02685	COG0831	urea catabolic process
E5206_02720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E5206_02765	COG1716	ATPase activity
E5206_02770	COG1716	ATPase activity
E5206_02785	COG0768	penicillin binding
E5206_02790	COG0515	serine threonine protein kinase
E5206_02795	COG0515	serine threonine protein kinase
E5206_02815	COG0444	Belongs to the ABC transporter superfamily
E5206_02820	COG4608	Belongs to the ABC transporter superfamily
E5206_02825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5206_02830	COG1940	carbohydrate kinase activity
E5206_02835	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
E5206_02840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E5206_02845	COG0363	glucosamine-6-phosphate deaminase activity
E5206_02855	COG3458	cephalosporin-C deacetylase activity
E5206_02870	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E5206_02890	COG1063	alcohol dehydrogenase
E5206_02995	COG3764	Sortase (surface protein transpeptidase)
E5206_03005	COG2818	Glycosylase
E5206_03010	COG0705	Rhomboid family
E5206_03025	COG1215	transferase activity, transferring glycosyl groups
E5206_03050	COG3266	domain, Protein
E5206_03055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E5206_03060	COG0187	DNA topoisomerase II activity
E5206_03065	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
E5206_03070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E5206_03075	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
E5206_03080	COG0592	DNA-directed DNA polymerase activity
E5206_03085	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5206_03090	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E5206_03095	COG0594	ribonuclease P activity
E5206_03100	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E5206_03105	COG0706	membrane insertase activity
E5206_03115	COG0357	Ribosomal RNA small subunit methyltransferase G
E5206_03120	COG1192	Involved in chromosome partitioning
E5206_03170	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E5206_03190	COG3118	belongs to the thioredoxin family
E5206_03195	COG0492	ferredoxin-NADP+ reductase activity
E5206_03215	COG0617	tRNA 3'-terminal CCA addition
E5206_03220	COG0406	alpha-ribazole phosphatase activity
E5206_03235	COG1136	(ABC) transporter
E5206_03240	COG1136	(ABC) transporter
E5206_03240	COG0577	efflux transmembrane transporter activity
E5206_03245	COG3850	Histidine kinase
E5206_03250	COG2197	response regulator
E5206_03255	COG0768	penicillin binding
E5206_03260	COG0488	(ABC) transporter
E5206_03265	COG0738	Major facilitator superfamily
E5206_03275	COG1131	(ABC) transporter
E5206_03285	COG1113	amino acid transport
E5206_03295	COG1362	aminopeptidase activity
E5206_03345	COG1215	transferase activity, transferring glycosyl groups
E5206_03360	COG1216	Glycosyl transferase, family 2
E5206_03370	COG2197	response regulator
E5206_03380	COG0360	Binds together with S18 to 16S ribosomal RNA
E5206_03390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E5206_03395	COG0359	binds to the 23S rRNA
E5206_03415	COG0305	Participates in initiation and elongation during chromosome replication
E5206_03420	COG0579	oxidoreductase
E5206_03425	COG1607	acyl-coa hydrolase
E5206_03430	COG0583	DNA-binding transcription factor activity
E5206_03435	COG2031	fatty acid transporter
E5206_03445	COG2259	Doxx family
E5206_03470	COG0697	spore germination
E5206_03485	COG1937	Protein conserved in bacteria
E5206_03520	COG1414	Transcriptional regulator
E5206_03525	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5206_03530	COG3185	4-Hydroxyphenylpyruvate dioxygenase
E5206_03535	COG3485	protocatechuate 3,4-dioxygenase
E5206_03540	COG3485	protocatechuate 3,4-dioxygenase
E5206_03555	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5206_03560	COG0183	Belongs to the thiolase family
E5206_03570	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5206_03575	COG1414	Transcriptional regulator
E5206_03585	COG1597	lipid kinase activity
E5206_03590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5206_03595	COG0673	inositol 2-dehydrogenase activity
E5206_03600	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5206_03605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5206_03635	COG2814	Major facilitator Superfamily
E5206_03655	COG1607	acyl-coa hydrolase
E5206_03665	COG2902	Dehydrogenase
E5206_03675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E5206_03690	COG1950	PFAM Membrane protein of
E5206_03695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5206_03705	COG0022	dehydrogenase e1 component
E5206_03710	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5206_03720	COG3485	protocatechuate 3,4-dioxygenase
E5206_03740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5206_03775	COG0673	inositol 2-dehydrogenase activity
E5206_03780	COG0686	Belongs to the AlaDH PNT family
E5206_03800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5206_03810	COG2213	PTS system mannitol-specific
E5206_03810	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5206_03815	COG0246	Mannitol dehydrogenase
E5206_03825	COG0477	Major facilitator Superfamily
E5206_03835	COG1309	transcriptional regulator
E5206_03865	COG1522	sequence-specific DNA binding
E5206_03875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5206_03900	COG1027	Aspartate ammonia-lyase
E5206_03910	COG2186	Transcriptional regulator
E5206_03920	COG0039	L-malate dehydrogenase activity
E5206_03945	COG4115	mRNA cleavage
E5206_03950	COG2161	toxin-antitoxin pair type II binding
E5206_03980	COG3177	Filamentation induced by cAMP protein fic
E5206_04025	COG0702	epimerase
E5206_04030	COG0667	Aldo Keto reductase
E5206_04040	COG3012	SEC-C Motif Domain Protein
E5206_04100	COG1100	Small GTP-binding protein
E5206_04170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5206_04170	COG1017	nitric oxide dioxygenase activity
E5206_04175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E5206_04180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5206_04185	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E5206_04230	COG0776	regulation of translation
E5206_04235	COG3336	cytochrome c oxidase
E5206_04250	COG0433	COG0433 Predicted ATPase
E5206_04260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5206_04265	COG3387	PFAM Glycoside hydrolase 15-related
E5206_04280	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E5206_04290	COG0531	amino acid
E5206_04320	COG0717	Belongs to the dCTP deaminase family
E5206_04340	COG0475	glutathione-regulated potassium exporter activity
E5206_04355	COG2111	Na H antiporter
E5206_04355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5206_04360	COG1006	Multisubunit Na H antiporter MnhC subunit
E5206_04375	COG2212	antiporter activity
E5206_04380	COG1320	monovalent cation:proton antiporter activity
E5206_04390	COG4721	ABC-type cobalt transport system, permease component
E5206_04395	COG1122	ATPase activity
E5206_04405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5206_04410	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E5206_04440	COG1760	l-serine dehydratase
E5206_04465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5206_04500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5206_04510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5206_04515	COG1414	Transcriptional regulator
E5206_04535	COG1960	acyl-CoA dehydrogenase activity
E5206_04540	COG0346	lactoylglutathione lyase activity
E5206_04550	COG1960	acyl-CoA dehydrogenase activity
E5206_04560	COG1053	succinate dehydrogenase
E5206_04565	COG2079	MmgE PrpD family protein
E5206_04570	COG0410	ABC transporter
E5206_04590	COG1309	transcriptional regulator
E5206_04605	COG1053	succinate dehydrogenase
E5206_04625	COG1053	succinate dehydrogenase
E5206_04625	COG3976	FMN-binding domain protein
E5206_04635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5206_04655	COG0183	Belongs to the thiolase family
E5206_04660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5206_04680	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_04690	COG1960	acyl-CoA dehydrogenase activity
E5206_04700	COG0477	Major facilitator Superfamily
E5206_04730	COG1280	lysine exporter protein (LysE YggA)
E5206_04745	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E5206_04750	COG4867	von Willebrand factor, type A
E5206_04780	COG2409	Drug exporters of the RND superfamily
E5206_04795	COG0443	Heat shock 70 kDa protein
E5206_04800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E5206_04805	COG0484	heat shock protein binding
E5206_04810	COG0789	Transcriptional regulator
E5206_04820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E5206_04850	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5206_04860	COG2807	transmembrane transport
E5206_04875	COG1113	amino acid transport
E5206_04880	COG0745	RESPONSE REGULATOR receiver
E5206_04885	COG2205	protein histidine kinase activity
E5206_04895	COG1477	protein flavinylation
E5206_04940	COG0135	phosphoribosylanthranilate isomerase activity
E5206_04945	COG2353	YceI-like domain
E5206_04965	COG3585	molybdate ion transport
E5206_04985	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5206_04990	COG0542	response to heat
E5206_05010	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5206_05035	COG3622	Belongs to the hyi family
E5206_05045	COG2267	carboxylic ester hydrolase activity
E5206_05120	COG0395	ABC-type sugar transport system, permease component
E5206_05125	COG1063	alcohol dehydrogenase
E5206_05150	COG1473	amidohydrolase
E5206_05165	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_05180	COG2814	Major facilitator Superfamily
E5206_05195	COG0318	PFAM AMP-dependent synthetase and ligase
E5206_05205	COG1846	Transcriptional regulator
E5206_05245	COG0477	Major facilitator Superfamily
E5206_05300	COG2814	Major facilitator Superfamily
E5206_05320	COG0693	protein deglycase activity
E5206_05325	COG1053	succinate dehydrogenase
E5206_05330	COG1063	alcohol dehydrogenase
E5206_05350	COG0477	Major facilitator Superfamily
E5206_05360	COG1902	pentaerythritol trinitrate reductase activity
E5206_05360	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5206_05370	COG0656	L-ascorbic acid biosynthetic process
E5206_05375	COG1053	succinate dehydrogenase
E5206_05390	COG2267	carboxylic ester hydrolase activity
E5206_05395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E5206_05400	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E5206_05435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5206_05445	COG4335	DNA alkylation repair
E5206_05465	COG0484	heat shock protein binding
E5206_05490	COG3387	PFAM Glycoside hydrolase 15-related
E5206_05500	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_05525	COG0151	Belongs to the GarS family
E5206_05530	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5206_05550	COG1132	(ABC) transporter
E5206_05555	COG1132	(ABC) transporter
E5206_05560	COG1408	metallophosphoesterase
E5206_05565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5206_05595	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E5206_05605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5206_05620	COG1051	belongs to the nudix hydrolase family
E5206_05670	COG1111	helicase
E5206_05670	COG1205	dead DEAH box helicase
E5206_05695	COG0789	Transcriptional regulator
E5206_05700	COG2890	protein-(glutamine-N5) methyltransferase activity
E5206_05710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5206_05710	COG1754	DNA topoisomerase type I activity
E5206_05725	COG3795	YCII-related domain
E5206_05735	COG0569	domain protein
E5206_05740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5206_05745	COG0123	including yeast histone deacetylase and acetoin utilization protein
E5206_05750	COG0640	Transcriptional regulator
E5206_05755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5206_05765	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5206_05780	COG0560	Phosphoserine phosphatase
E5206_05790	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E5206_05805	COG2353	YceI-like domain
E5206_05810	COG0406	alpha-ribazole phosphatase activity
E5206_05815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5206_05820	COG0785	Cytochrome C biogenesis protein
E5206_05830	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5206_05860	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E5206_05885	COG3237	CsbD-like
E5206_05900	COG0183	Belongs to the thiolase family
E5206_05905	COG1024	Enoyl-CoA hydratase
E5206_05910	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5206_05920	COG1473	amidohydrolase
E5206_05945	COG1017	nitric oxide dioxygenase activity
E5206_05945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5206_05950	COG2050	protein possibly involved in aromatic compounds catabolism
E5206_05955	COG2030	dehydratase
E5206_05955	COG1012	belongs to the aldehyde dehydrogenase family
E5206_05980	COG2050	protein possibly involved in aromatic compounds catabolism
E5206_05985	COG0280	phosphate acetyltransferase
E5206_05985	COG0857	belongs to the CobB CobQ family
E5206_05990	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5206_06005	COG2072	flavoprotein involved in K transport
E5206_06035	COG1316	TRANSCRIPTIONal
E5206_06040	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E5206_06045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5206_06050	COG3396	Phenylacetate-CoA oxygenase
E5206_06055	COG3460	Phenylacetate-CoA oxygenase
E5206_06060	COG3396	Phenylacetate-CoA oxygenase
E5206_06065	COG2151	metal-sulfur cluster biosynthetic enzyme
E5206_06070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5206_06075	COG1024	Enoyl-CoA hydratase
E5206_06080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5206_06105	COG0489	protein tyrosine kinase activity
E5206_06125	COG1215	transferase activity, transferring glycosyl groups
E5206_06150	COG0022	dehydrogenase e1 component
E5206_06155	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5206_06160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5206_06165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5206_06175	COG0297	glycogen (starch) synthase activity
E5206_06285	COG0745	RESPONSE REGULATOR receiver
E5206_06290	COG4948	Mandelate Racemase Muconate Lactonizing
E5206_06305	COG0018	arginyl-trna synthetase
E5206_06310	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E5206_06320	COG1126	abc transporter atp-binding protein
E5206_06325	COG0765	amino acid transport
E5206_06335	COG1169	isochorismate synthase
E5206_06340	COG2226	methyltransferase
E5206_06365	COG2860	membrane
E5206_06375	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5206_06380	COG0175	sulfate reduction
E5206_06405	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E5206_06420	COG1648	precorrin-2 dehydrogenase activity
E5206_06420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5206_06440	COG2186	Transcriptional regulator
E5206_06450	COG3835	regulator
E5206_06455	COG1012	belongs to the aldehyde dehydrogenase family
E5206_06515	COG0531	amino acid
E5206_06540	COG0501	Belongs to the peptidase M48B family
E5206_06545	COG1666	GTP binding
E5206_06590	COG2318	DinB family
E5206_06605	COG1131	(ABC) transporter
E5206_06610	COG3559	Exporter of polyketide antibiotics
E5206_06640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5206_06650	COG0318	PFAM AMP-dependent synthetase and ligase
E5206_06670	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E5206_06685	COG1051	belongs to the nudix hydrolase family
E5206_06730	COG1960	acyl-CoA dehydrogenase activity
E5206_06755	COG0702	epimerase
E5206_06775	COG1940	carbohydrate kinase activity
E5206_06780	COG0366	Alpha amylase catalytic
E5206_06785	COG4989	oxidoreductase activity
E5206_06800	COG0659	secondary active sulfate transmembrane transporter activity
E5206_06810	COG2030	dehydratase
E5206_06820	COG0738	Major facilitator superfamily
E5206_06825	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E5206_06840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E5206_06850	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E5206_06855	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E5206_06865	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E5206_06870	COG0456	acetyltransferase
E5206_06875	COG0745	RESPONSE REGULATOR receiver
E5206_06885	COG3485	protocatechuate 3,4-dioxygenase
E5206_06945	COG2197	response regulator
E5206_06950	COG0436	Aminotransferase
E5206_06970	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E5206_06975	COG0081	regulation of translation
E5206_06985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E5206_06990	COG0222	ribosome binding
E5206_06995	COG0442	prolyl-tRNA aminoacylation
E5206_07000	COG0183	Belongs to the thiolase family
E5206_07005	COG0085	RNA polymerase activity
E5206_07010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5206_07015	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E5206_07020	COG0049	tRNA binding
E5206_07025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E5206_07030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5206_07045	COG0051	transcription antitermination factor activity, RNA binding
E5206_07050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E5206_07055	COG0088	Forms part of the polypeptide exit tunnel
E5206_07060	COG0089	rRNA binding
E5206_07065	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E5206_07070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E5206_07075	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E5206_07080	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E5206_07085	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E5206_07090	COG0255	Belongs to the universal ribosomal protein uL29 family
E5206_07095	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E5206_07100	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E5206_07105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E5206_07110	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E5206_07115	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5206_07120	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5206_07130	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5206_07135	COG1841	ribosomal large subunit assembly
E5206_07140	COG0200	Binds to the 23S rRNA
E5206_07150	COG0563	adenylate kinase activity
E5206_07170	COG1175	transmembrane transport
E5206_07175	COG3191	aminopeptidase activity
E5206_07180	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E5206_07185	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5206_07190	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E5206_07195	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E5206_07200	COG0202	RNA polymerase activity
E5206_07205	COG0203	ribosomal protein L17
E5206_07210	COG0101	tRNA pseudouridine synthase activity
E5206_07240	COG2894	cell division
E5206_07275	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E5206_07280	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5206_07290	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E5206_07290	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E5206_07300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5206_07305	COG1970	mechanosensitive ion channel activity
E5206_07310	COG1876	peptidase activity
E5206_07315	COG1072	(Pantothenic acid kinase))
E5206_07320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5206_07325	COG0736	holo-[acyl-carrier-protein] synthase activity
E5206_07350	COG0667	Aldo Keto reductase
E5206_07360	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E5206_07365	COG0438	transferase activity, transferring glycosyl groups
E5206_07375	COG1105	Belongs to the carbohydrate kinase PfkB family
E5206_07380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5206_07385	COG0802	atpase or kinase
E5206_07400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E5206_07405	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E5206_07410	COG1472	Belongs to the glycosyl hydrolase 3 family
E5206_07415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5206_07430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E5206_07435	COG0459	protein refolding
E5206_07440	COG2755	lipolytic protein G-D-S-L family
E5206_07440	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E5206_07450	COG1132	(ABC) transporter
E5206_07455	COG0516	GMP reductase activity
E5206_07460	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E5206_07480	COG0519	Catalyzes the synthesis of GMP from XMP
E5206_07480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5206_07500	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5206_07505	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5206_07575	COG0640	Transcriptional regulator
E5206_07600	COG2890	protein-(glutamine-N5) methyltransferase activity
E5206_07605	COG0488	(ABC) transporter
E5206_07615	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5206_07620	COG0598	Magnesium transport protein CorA
E5206_07640	COG0626	cystathionine gamma-synthase activity
E5206_07645	COG2814	Major facilitator Superfamily
E5206_07655	COG2971	BadF BadG BcrA BcrD
E5206_07670	COG1174	glycine betaine transport
E5206_07675	COG1174	glycine betaine transport
E5206_07690	COG2326	polyphosphate kinase activity
E5206_07695	COG1722	exodeoxyribonuclease VII activity
E5206_07700	COG1570	exodeoxyribonuclease VII activity
E5206_07710	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E5206_07715	COG1322	Protein conserved in bacteria
E5206_07720	COG0012	GTP binding
E5206_07725	COG4166	transmembrane transport
E5206_07735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5206_07745	COG4172	Belongs to the ABC transporter superfamily
E5206_07750	COG4166	transmembrane transport
E5206_07810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5206_07815	COG3226	Transcriptional regulator
E5206_07830	COG2171	N-acyltransferase activity
E5206_07835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5206_07840	COG0765	amino acid transport
E5206_07845	COG0765	amino acid transport
E5206_07855	COG1126	abc transporter atp-binding protein
E5206_07885	COG1595	DNA-templated transcription, initiation
E5206_07895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5206_07900	COG2151	metal-sulfur cluster biosynthetic enzyme
E5206_07900	COG0489	protein tyrosine kinase activity
E5206_07910	COG2239	Acts as a magnesium transporter
E5206_07940	COG0006	proline dipeptidase activity
E5206_07945	COG0613	PHP domain protein
E5206_07950	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E5206_07955	COG0513	Belongs to the DEAD box helicase family
E5206_07970	COG0352	thiamine-phosphate diphosphorylase activity
E5206_07985	COG2022	thiamine diphosphate biosynthetic process
E5206_07990	COG2154	pterin-4-alpha-carbinolamine dehydratase
E5206_08025	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E5206_08050	COG0181	hydroxymethylbilane synthase activity
E5206_08060	COG0113	porphobilinogen synthase activity
E5206_08070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E5206_08080	COG0765	amino acid transport
E5206_08085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5206_08115	COG2816	NAD+ diphosphatase activity
E5206_08135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5206_08140	COG1615	UPF0182 protein
E5206_08155	COG0415	Belongs to the DNA photolyase family
E5206_08160	COG1842	Phage shock protein A
E5206_08170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5206_08175	COG2086	electron transfer activity
E5206_08180	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E5206_08185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E5206_08190	COG3265	gluconokinase activity
E5206_08205	COG1595	DNA-templated transcription, initiation
E5206_08210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E5206_08240	COG0482	sulfurtransferase activity
E5206_08290	COG0601	transmembrane transport
E5206_08295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5206_08300	COG4172	Belongs to the ABC transporter superfamily
E5206_08330	COG5401	PFAM Sporulation and spore germination
E5206_08335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5206_08340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E5206_08345	COG3214	Protein conserved in bacteria
E5206_08350	COG0653	protein targeting
E5206_08385	COG2902	Dehydrogenase
E5206_08405	COG1674	ftsk spoiiie
E5206_08405	COG0433	COG0433 Predicted ATPase
E5206_08415	COG1216	Glycosyl transferase, family 2
E5206_08435	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E5206_08455	COG1216	Glycosyl transferase, family 2
E5206_08465	COG0004	ammonium transporteR
E5206_08470	COG1216	Glycosyl transferase, family 2
E5206_08475	COG1088	dTDP-glucose 4,6-dehydratase activity
E5206_08550	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E5206_08555	COG2884	Cell division ATP-binding protein ftsE
E5206_08560	COG2177	Part of the ABC transporter FtsEX involved in
E5206_08565	COG0739	heme binding
E5206_08570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E5206_08605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5206_08610	COG0483	inositol monophosphate 1-phosphatase activity
E5206_08615	COG1473	amidohydrolase
E5206_08630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5206_08640	COG1595	DNA-templated transcription, initiation
E5206_08665	COG0567	Dehydrogenase, E1 component
E5206_08665	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5206_08690	COG1121	(ABC) transporter
E5206_08705	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E5206_08730	COG1064	alcohol dehydrogenase
E5206_08735	COG0537	adenosine 5'-monophosphoramidase activity
E5206_08740	COG1643	Atp-dependent helicase
E5206_08775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5206_08775	COG1017	nitric oxide dioxygenase activity
E5206_08790	COG0018	arginyl-trna synthetase
E5206_08795	COG0019	diaminopimelate decarboxylase activity
E5206_08800	COG0460	homoserine dehydrogenase
E5206_08805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5206_08810	COG0083	homoserine kinase activity
E5206_08820	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5206_08825	COG2890	protein-(glutamine-N5) methyltransferase activity
E5206_08830	COG0009	L-threonylcarbamoyladenylate synthase
E5206_08845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5206_08860	COG0356	it plays a direct role in the translocation of protons across the membrane
E5206_08865	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5206_08870	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E5206_08875	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5206_08880	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E5206_08885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E5206_08890	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5206_08895	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E5206_08905	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E5206_08910	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E5206_08920	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
E5206_08965	COG0363	glucosamine-6-phosphate deaminase activity
E5206_08985	COG1335	isochorismatase
E5206_08995	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E5206_09005	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5206_09010	COG1234	tRNA 3'-trailer cleavage
E5206_09015	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E5206_09020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5206_09025	COG0586	Pfam SNARE associated Golgi protein
E5206_09045	COG2149	membrane
E5206_09060	COG0420	3'-5' exonuclease activity
E5206_09065	COG0419	ATPase involved in DNA repair
E5206_09070	COG1414	Transcriptional regulator
E5206_09085	COG0477	Major facilitator Superfamily
E5206_09095	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5206_09100	COG0022	dehydrogenase e1 component
E5206_09110	COG1113	amino acid transport
E5206_09130	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E5206_09135	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E5206_09145	COG1104	cysteine desulfurase activity
E5206_09165	COG1305	Transglutaminase-like
E5206_09170	COG1846	Transcriptional regulator
E5206_09175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5206_09190	COG0579	oxidoreductase
E5206_09195	COG0747	negative chemotaxis
E5206_09360	COG0739	heme binding
E5206_09385	COG0739	heme binding
E5206_09620	COG0228	four-way junction DNA binding
E5206_09625	COG0129	dihydroxy-acid dehydratase activity
E5206_09635	COG0440	acetolactate synthase activity
E5206_09640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E5206_09645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5206_09655	COG1136	(ABC) transporter
E5206_09655	COG0577	efflux transmembrane transporter activity
E5206_09675	COG0473	3-isopropylmalate dehydrogenase activity
E5206_09680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E5206_09690	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5206_09695	COG1695	Transcriptional regulator
E5206_09700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5206_09775	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5206_09865	COG0477	Major facilitator Superfamily
E5206_09870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5206_09895	COG1760	l-serine dehydratase
E5206_09900	COG0386	Belongs to the glutathione peroxidase family
E5206_09915	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E5206_09955	COG1414	Transcriptional regulator
E5206_09960	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5206_09965	COG0066	3-isopropylmalate dehydratase activity
E5206_09970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5206_09980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E5206_09985	COG1181	Belongs to the D-alanine--D-alanine ligase family
E5206_10000	COG1461	Dihydroxyacetone kinase
E5206_10010	COG0742	ribosomal rna small subunit methyltransferase
E5206_10025	COG0300	oxidoreductase activity
E5206_10030	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E5206_10040	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E5206_10045	COG0571	ribonuclease III activity
E5206_10050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E5206_10065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5206_10070	COG0318	PFAM AMP-dependent synthetase and ligase
E5206_10075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5206_10105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E5206_10120	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E5206_10130	COG2514	catechol 2,3-dioxygenase activity
E5206_10140	COG0228	four-way junction DNA binding
E5206_10145	COG1837	Belongs to the UPF0109 family
E5206_10150	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E5206_10155	COG0336	Belongs to the RNA methyltransferase TrmD family
E5206_10160	COG0335	large ribosomal subunit rRNA binding
E5206_10165	COG0681	Belongs to the peptidase S26 family
E5206_10175	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5206_10185	COG0792	nuclease activity
E5206_10190	COG0606	chelatase, subunit chli
E5206_10200	COG4974	Belongs to the 'phage' integrase family
E5206_10215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5206_10220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5206_10225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5206_10240	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E5206_10280	COG0477	Major facilitator Superfamily
E5206_10285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5206_10295	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_10300	COG1063	alcohol dehydrogenase
E5206_10310	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E5206_10315	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_10320	COG1045	serine acetyltransferase
E5206_10330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5206_10335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E5206_10345	COG3022	response to hydroperoxide
E5206_10385	COG2326	polyphosphate kinase activity
E5206_10390	COG0242	peptide deformylase activity
E5206_10425	COG5416	Lipopolysaccharide assembly protein A domain
E5206_10435	COG0598	Magnesium transport protein CorA
E5206_10460	COG1946	Acyl-CoA thioesterase
E5206_10475	COG0668	transmembrane transport
E5206_10495	COG0698	ribose 5-phosphate isomerase
E5206_10515	COG0544	peptidyl-prolyl cis-trans isomerase activity
E5206_10520	COG0740	serine-type endopeptidase activity
E5206_10525	COG0740	serine-type endopeptidase activity
E5206_10530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E5206_10535	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E5206_10540	COG3387	PFAM Glycoside hydrolase 15-related
E5206_10545	COG0525	valine-tRNA ligase activity
E5206_10550	COG3189	MarR family transcriptional regulator
E5206_10565	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5206_10570	COG0285	dihydrofolate synthase activity
E5206_10580	COG0105	UTP biosynthetic process
E5206_10590	COG1530	ribonuclease E activity
E5206_10595	COG0352	thiamine-phosphate diphosphorylase activity
E5206_10595	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E5206_10595	COG0351	phosphomethylpyrimidine kinase
E5206_10600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5206_10605	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E5206_10610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5206_10615	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E5206_10620	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E5206_10630	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E5206_10640	COG0799	negative regulation of ribosome biogenesis
E5206_10655	COG2824	Alkylphosphonate utilization operon protein PhnA
E5206_10660	COG0492	ferredoxin-NADP+ reductase activity
E5206_10670	COG1940	carbohydrate kinase activity
E5206_10670	COG1846	Transcriptional regulator
E5206_10685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5206_10690	COG0574	Belongs to the PEP-utilizing enzyme family
E5206_10690	COG3848	Pyruvate phosphate dikinase
E5206_10720	COG1012	belongs to the aldehyde dehydrogenase family
E5206_10740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5206_10750	COG1780	Probably involved in ribonucleotide reductase function
E5206_10755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5206_10760	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5206_10775	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E5206_10780	COG4804	nuclease activity
E5206_10805	COG0586	Pfam SNARE associated Golgi protein
E5206_10845	COG3547	Transposase (IS116 IS110 IS902 family)
E5206_10850	COG3547	Transposase (IS116 IS110 IS902 family)
E5206_10855	COG0668	transmembrane transport
E5206_10880	COG0640	Transcriptional regulator
E5206_10890	COG2239	Acts as a magnesium transporter
E5206_10910	COG1316	TRANSCRIPTIONal
E5206_10925	COG1968	undecaprenyl-diphosphatase activity
E5206_10995	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E5206_11010	COG2188	Transcriptional regulator
E5206_11015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5206_11035	COG0598	Magnesium transport protein CorA
E5206_11060	COG0210	DNA helicase
E5206_11065	COG0210	DNA helicase
E5206_11080	COG1131	(ABC) transporter
E5206_11140	COG1136	(ABC) transporter
E5206_11145	COG1309	transcriptional regulator
E5206_11160	COG3265	gluconokinase activity
E5206_11195	COG0297	glycogen (starch) synthase activity
E5206_11200	COG1132	(ABC) transporter
E5206_11220	COG3290	protein histidine kinase activity
E5206_11225	COG4565	transcriptional regulatory protein
E5206_11235	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E5206_11235	COG2755	lipolytic protein G-D-S-L family
E5206_11245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5206_11250	COG0765	amino acid transport
E5206_11255	COG1126	abc transporter atp-binding protein
E5206_11270	COG3848	Pyruvate phosphate dikinase
E5206_11270	COG0574	Belongs to the PEP-utilizing enzyme family
E5206_11310	COG3971	2-oxopent-4-enoate hydratase activity
E5206_11325	COG1595	DNA-templated transcription, initiation
E5206_11340	COG0569	domain protein
E5206_11340	COG0475	glutathione-regulated potassium exporter activity
E5206_11360	COG5002	protein histidine kinase activity
E5206_11365	COG0745	RESPONSE REGULATOR receiver
E5206_11375	COG0671	phosphoesterase, PA-phosphatase related
E5206_11380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E5206_11450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5206_11465	COG2135	peptidase activity
E5206_11480	COG2217	Heavy metal translocating P-type atpase
E5206_11500	COG2814	Major facilitator Superfamily
E5206_11510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5206_11525	COG2814	Major facilitator Superfamily
E5206_11535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5206_11555	COG0730	response to heat
E5206_11580	COG0477	Major facilitator Superfamily
E5206_11590	COG1937	Protein conserved in bacteria
E5206_11610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5206_11615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5206_11645	COG0587	DNA-directed DNA polymerase activity
E5206_11650	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E5206_11665	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E5206_11685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5206_11690	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
E5206_11695	COG0217	transcriptional regulatory protein
E5206_11700	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E5206_11705	COG0632	four-way junction helicase activity
E5206_11710	COG2255	four-way junction helicase activity
E5206_11720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5206_11725	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5206_11730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5206_11740	COG1196	nuclear chromosome segregation
E5206_11750	COG0124	histidyl-tRNA synthetase
E5206_11755	COG2897	thiosulfate sulfurtransferase activity
E5206_11760	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5206_11765	COG0477	Major facilitator Superfamily
E5206_11770	COG1414	Transcriptional regulator
E5206_11800	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5206_11815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5206_11830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5206_11835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E5206_11840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5206_11845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E5206_11855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E5206_11860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5206_11865	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E5206_11870	COG0540	Belongs to the ATCase OTCase family
E5206_11875	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5206_11885	COG0505	Belongs to the CarA family
E5206_11890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5206_11895	COG0284	orotidine-5'-phosphate decarboxylase activity
E5206_11900	COG0194	GDP metabolic process
E5206_11905	COG0194	GDP metabolic process
E5206_11910	COG1758	RNA polymerase activity
E5206_11920	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E5206_11940	COG0656	L-ascorbic acid biosynthetic process
E5206_11950	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E5206_11955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5206_11960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5206_11965	COG0495	leucyl-tRNA aminoacylation
E5206_11970	COG1307	EDD domain protein, DegV family
E5206_11985	COG2183	response to ionizing radiation
E5206_12000	COG0268	Binds directly to 16S ribosomal RNA
E5206_12010	COG0481	GTPase activity
E5206_12030	COG1420	regulation of RNA biosynthetic process
E5206_12035	COG0484	heat shock protein binding
E5206_12040	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5206_12050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5206_12060	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E5206_12070	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E5206_12075	COG1316	TRANSCRIPTIONal
E5206_12080	COG3590	peptidase
E5206_12085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5206_12090	COG1381	Involved in DNA repair and RecF pathway recombination
E5206_12095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5206_12100	COG2267	carboxylic ester hydrolase activity
E5206_12105	COG0167	dihydroorotate dehydrogenase activity
E5206_12125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E5206_12130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5206_12140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5206_12150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E5206_12155	COG0723	plastoquinol--plastocyanin reductase activity
E5206_12160	COG2010	Cytochrome c
E5206_12165	COG1845	cytochrome c oxidase, subunit III
E5206_12170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5206_12200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5206_12200	COG0574	Belongs to the PEP-utilizing enzyme family
E5206_12220	COG0439	Biotin carboxylase
E5206_12225	COG0511	ligase activity, forming carbon-carbon bonds
E5206_12230	COG1414	Transcriptional regulator
E5206_12235	COG2271	Major facilitator Superfamily
E5206_12240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5206_12255	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_12270	COG5001	Diguanylate cyclase
E5206_12270	COG3300	MHYT domain
E5206_12310	COG1063	alcohol dehydrogenase
E5206_12320	COG1175	transmembrane transport
E5206_12330	COG0673	inositol 2-dehydrogenase activity
E5206_12395	COG3344	reverse transcriptase
E5206_12405	COG1012	belongs to the aldehyde dehydrogenase family
E5206_12420	COG1012	belongs to the aldehyde dehydrogenase family
E5206_12425	COG2124	cytochrome p450
E5206_12430	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E5206_12435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5206_12435	COG0519	Catalyzes the synthesis of GMP from XMP
E5206_12440	COG0174	glutamine synthetase
E5206_12455	COG2186	Transcriptional regulator
E5206_12490	COG3424	synthase
E5206_12510	COG0242	peptide deformylase activity
E5206_12535	COG1216	Glycosyl transferase, family 2
E5206_12540	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E5206_12545	COG4581	dead DEAH box helicase
E5206_12550	COG0805	protein transport
E5206_12555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5206_12580	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
E5206_12585	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
E5206_12590	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
E5206_12600	COG4122	O-methyltransferase activity
E5206_12605	COG1222	aaa ATPase
E5206_12620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5206_12630	COG0215	cysteine-tRNA ligase activity
E5206_12635	COG1968	undecaprenyl-diphosphatase activity
E5206_12640	COG0656	L-ascorbic acid biosynthetic process
E5206_12660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5206_12755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5206_12790	COG0435	Glutathione S-transferase
E5206_12805	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_12810	COG0183	Belongs to the thiolase family
E5206_12825	COG0297	glycogen (starch) synthase activity
E5206_12830	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5206_12880	COG2855	membrane
E5206_12895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5206_12910	COG0254	rRNA binding
E5206_12925	COG1119	ATPase activity
E5206_12930	COG0560	Phosphoserine phosphatase
E5206_12930	COG3830	Belongs to the UPF0237 family
E5206_12935	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_12945	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_12965	COG0488	(ABC) transporter
E5206_12970	COG1268	BioY protein
E5206_12975	COG1122	ATPase activity
E5206_12985	COG0183	Belongs to the thiolase family
E5206_12990	COG0318	PFAM AMP-dependent synthetase and ligase
E5206_13000	COG2151	metal-sulfur cluster biosynthetic enzyme
E5206_13005	COG0396	ATPase activity
E5206_13030	COG1131	(ABC) transporter
E5206_13040	COG1612	heme a metabolic process
E5206_13045	COG0586	Pfam SNARE associated Golgi protein
E5206_13050	COG0109	protoheme IX farnesyltransferase activity
E5206_13060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5206_13065	COG0166	Belongs to the GPI family
E5206_13080	COG0363	glucosamine-6-phosphate deaminase activity
E5206_13090	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E5206_13095	COG0149	triose-phosphate isomerase activity
E5206_13100	COG0126	phosphoglycerate kinase activity
E5206_13105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5206_13110	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E5206_13115	COG1481	regulation of sporulation
E5206_13120	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E5206_13125	COG1660	Displays ATPase and GTPase activities
E5206_13130	COG0322	excinuclease ABC activity
E5206_13135	COG0318	PFAM AMP-dependent synthetase and ligase
E5206_13135	COG0204	Acyl-transferase
E5206_13160	COG1132	(ABC) transporter
E5206_13165	COG4106	trans-aconitate 2-methyltransferase activity
E5206_13205	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E5206_13240	COG0861	Integral membrane protein TerC family
E5206_13245	COG0556	nucleotide-excision repair
E5206_13250	COG0237	dephospho-CoA kinase activity
E5206_13250	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E5206_13255	COG1739	Uncharacterized protein family UPF0029
E5206_13265	COG0539	negative regulation of cytoplasmic translation
E5206_13270	COG4552	Acetyltransferase involved in intracellular survival and related
E5206_13280	COG2050	protein possibly involved in aromatic compounds catabolism
E5206_13285	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E5206_13300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5206_13305	COG2814	Major facilitator Superfamily
E5206_13320	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5206_13335	COG0589	response to stress
E5206_13345	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E5206_13350	COG0318	PFAM AMP-dependent synthetase and ligase
E5206_13390	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E5206_13390	COG3608	succinylglutamate desuccinylase aspartoacylase
E5206_13400	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E5206_13415	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E5206_13415	COG3608	succinylglutamate desuccinylase aspartoacylase
E5206_13435	COG0009	L-threonylcarbamoyladenylate synthase
E5206_13450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5206_13460	COG0390	transport system, permease component
E5206_13495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5206_13495	COG0723	plastoquinol--plastocyanin reductase activity
E5206_13530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5206_13550	COG1819	glycosyl
E5206_13560	COG0076	glutamate decarboxylase activity
E5206_13570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5206_13575	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E5206_13585	COG3622	Belongs to the hyi family
E5206_13590	COG0673	inositol 2-dehydrogenase activity
E5206_13595	COG1609	Transcriptional regulator
E5206_13600	COG2124	cytochrome p450
E5206_13605	COG1643	Atp-dependent helicase
E5206_13615	COG0702	epimerase
E5206_13640	COG3226	Transcriptional regulator
E5206_13645	COG4977	sequence-specific DNA binding
E5206_13655	COG1012	belongs to the aldehyde dehydrogenase family
E5206_13660	COG0477	Major facilitator Superfamily
E5206_13665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5206_13670	COG1846	Transcriptional regulator
E5206_13705	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E5206_13710	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E5206_13715	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E5206_13755	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5206_13785	COG1960	acyl-CoA dehydrogenase activity
E5206_13790	COG0318	PFAM AMP-dependent synthetase and ligase
E5206_13795	COG3384	dioxygenase
E5206_13800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5206_13805	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E5206_13810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5206_13835	COG0747	negative chemotaxis
E5206_13875	COG0583	DNA-binding transcription factor activity
E5206_13900	COG2207	Transcriptional regulator
E5206_13905	COG1960	acyl-CoA dehydrogenase activity
E5206_13925	COG1454	alcohol dehydrogenase
E5206_13955	COG0667	Aldo Keto reductase
E5206_13980	COG3547	Transposase (IS116 IS110 IS902 family)
E5206_13995	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E5206_14000	COG0745	RESPONSE REGULATOR receiver
E5206_14005	COG5002	protein histidine kinase activity
E5206_14015	COG0438	transferase activity, transferring glycosyl groups
E5206_14025	COG1132	(ABC) transporter
E5206_14045	COG3511	phospholipase C
E5206_14085	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_14090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5206_14100	COG0583	DNA-binding transcription factor activity
E5206_14105	COG1053	succinate dehydrogenase
E5206_14120	COG2159	amidohydrolase
E5206_14145	COG0667	Aldo Keto reductase
E5206_14175	COG3547	Transposase (IS116 IS110 IS902 family)
E5206_14185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5206_14200	COG3547	Transposase (IS116 IS110 IS902 family)
E5206_14235	COG4702	Belongs to the UPF0303 family
E5206_14270	COG2801	Transposase and inactivated derivatives
E5206_14275	COG4974	Belongs to the 'phage' integrase family
E5206_14280	COG0582	viral genome integration into host DNA
E5206_14300	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5206_14320	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E5206_14325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5206_14330	COG2009	succinate dehydrogenase
E5206_14335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E5206_14340	COG3189	MarR family transcriptional regulator
E5206_14345	COG2094	Belongs to the DNA glycosylase MPG family
E5206_14360	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E5206_14365	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E5206_14375	COG0183	Belongs to the thiolase family
E5206_14385	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E5206_14395	COG0318	PFAM AMP-dependent synthetase and ligase
E5206_14410	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_14415	COG1960	acyl-CoA dehydrogenase activity
E5206_14430	COG0183	Belongs to the thiolase family
E5206_14445	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_14460	COG1960	acyl-CoA dehydrogenase activity
E5206_14500	COG0583	DNA-binding transcription factor activity
E5206_14510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5206_14515	COG0318	PFAM AMP-dependent synthetase and ligase
E5206_14535	COG0477	Major facilitator Superfamily
E5206_14540	COG0318	PFAM AMP-dependent synthetase and ligase
E5206_14550	COG0559	Belongs to the binding-protein-dependent transport system permease family
E5206_14555	COG1129	ABC transporter
E5206_14570	COG4569	acetaldehyde dehydrogenase (acetylating) activity
E5206_14590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5206_14595	COG1309	transcriptional regulator
E5206_14630	COG2084	Dehydrogenase
E5206_14635	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E5206_14635	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E5206_14640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5206_14650	COG1609	Transcriptional regulator
E5206_14660	COG3265	gluconokinase activity
E5206_14665	COG0183	Belongs to the thiolase family
E5206_14670	COG1012	belongs to the aldehyde dehydrogenase family
E5206_14675	COG1024	Enoyl-CoA hydratase
E5206_14680	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5206_14710	COG0583	DNA-binding transcription factor activity
E5206_14720	COG1960	acyl-CoA dehydrogenase activity
E5206_14740	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5206_14745	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5206_14755	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_14760	COG0583	DNA-binding transcription factor activity
E5206_14765	COG3284	Transcriptional regulator
E5206_14775	COG1063	alcohol dehydrogenase
E5206_14825	COG1309	transcriptional regulator
E5206_14845	COG2814	Major facilitator Superfamily
E5206_14875	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5206_14900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5206_14905	COG1116	anion transmembrane transporter activity
E5206_14915	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_14930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5206_14935	COG1116	anion transmembrane transporter activity
E5206_14945	COG1902	pentaerythritol trinitrate reductase activity
E5206_14975	COG0469	pyruvate kinase activity
E5206_14985	COG0070	glutamate synthase
E5206_14985	COG0069	glutamate synthase activity
E5206_14985	COG0067	glutamate synthase
E5206_14990	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E5206_14995	COG0159	tryptophan synthase activity
E5206_15000	COG0133	tryptophan synthase activity
E5206_15005	COG0134	indole-3-glycerol-phosphate synthase activity
E5206_15025	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5206_15035	COG0107	imidazoleglycerol-phosphate synthase activity
E5206_15040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5206_15045	COG0140	phosphoribosyl-ATP diphosphatase activity
E5206_15050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E5206_15060	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5206_15060	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5206_15075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5206_15085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E5206_15090	COG0242	peptide deformylase activity
E5206_15100	COG4214	carbohydrate transport
E5206_15155	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E5206_15160	COG2353	YceI-like domain
E5206_15175	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5206_15200	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E5206_15205	COG0183	Belongs to the thiolase family
E5206_15210	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5206_15210	COG1024	Enoyl-CoA hydratase
E5206_15220	COG0667	Aldo Keto reductase
E5206_15235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5206_15240	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E5206_15245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5206_15250	COG0531	amino acid
E5206_15255	COG0569	domain protein
E5206_15280	COG0756	dUTP diphosphatase activity
E5206_15300	COG1435	thymidine kinase activity
E5206_15315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5206_15315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5206_15320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E5206_15330	COG4988	ABC transporter
E5206_15335	COG1294	oxidase, subunit
E5206_15340	COG1271	oxidase subunit
E5206_15355	COG0187	DNA topoisomerase II activity
E5206_15365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5206_15385	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5206_15390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5206_15395	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5206_15405	COG1764	response to oxidative stress
E5206_15410	COG0793	Belongs to the peptidase S41A family
E5206_15410	COG4946	Tricorn protease homolog
E5206_15415	COG1090	epimerase
E5206_15425	COG0321	lipoyl(octanoyl) transferase activity
E5206_15430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5206_15465	COG1126	abc transporter atp-binding protein
E5206_15470	COG0765	amino acid transport
E5206_15475	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E5206_15480	COG0174	glutamine synthetase
E5206_15485	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E5206_15505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5206_15510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5206_15525	COG0587	DNA-directed DNA polymerase activity
E5206_15535	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E5206_15540	COG3599	regulation of cell shape
E5206_15550	COG1799	cell septum assembly
E5206_15555	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E5206_15565	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5206_15575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5206_15580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5206_15585	COG0772	Belongs to the SEDS family
E5206_15590	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E5206_15595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5206_15600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5206_15605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5206_15610	COG0768	penicillin binding
E5206_15620	COG0275	rRNA processing
E5206_15625	COG2001	Belongs to the MraZ family
E5206_15645	COG0142	geranyltranstransferase activity
E5206_15655	COG1388	LysM domain
E5206_15655	COG3942	CHAP domain
E5206_15660	COG2815	serine threonine protein kinase
E5206_15660	COG0515	serine threonine protein kinase
E5206_15665	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E5206_15685	COG1940	carbohydrate kinase activity
E5206_15695	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E5206_15700	COG1192	Involved in chromosome partitioning
E5206_15720	COG1716	ATPase activity
E5206_15725	COG0509	glycine decarboxylation via glycine cleavage system
E5206_15735	COG1160	GTP binding
E5206_15745	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E5206_15760	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5206_15765	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E5206_15775	COG1301	dicarboxylic acid transport
E5206_15780	COG3290	protein histidine kinase activity
E5206_15800	COG2079	MmgE PrpD family protein
E5206_15805	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E5206_15840	COG0504	CTP synthase activity
E5206_15845	COG0497	DNA recombination
E5206_15850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5206_15865	COG0647	UMP catabolic process
E5206_15890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5206_15900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5206_15915	COG2094	Belongs to the DNA glycosylase MPG family
E5206_15925	COG2169	Transcriptional regulator
E5206_15925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E5206_15930	COG0165	Argininosuccinate lyase
E5206_15935	COG0137	argininosuccinate synthase activity
E5206_15940	COG1438	arginine binding
E5206_15945	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5206_15950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5206_15955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5206_15960	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E5206_15965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E5206_15995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5206_16000	COG1621	beta-fructofuranosidase activity
E5206_16005	COG0395	ABC-type sugar transport system, permease component
E5206_16020	COG1609	Transcriptional regulator
E5206_16045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5206_16045	COG0072	phenylalanine-tRNA ligase activity
E5206_16050	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E5206_16075	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E5206_16080	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E5206_16090	COG2814	Major facilitator Superfamily
E5206_16100	COG2261	transglycosylase associated protein
E5206_16105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5206_16110	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E5206_16115	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E5206_16120	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E5206_16130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5206_16135	COG2011	ABC-type metal ion transport system permease component
E5206_16140	COG1464	Belongs to the NlpA lipoprotein family
E5206_16160	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E5206_16165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E5206_16170	COG0131	Imidazoleglycerol-phosphate dehydratase
E5206_16175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5206_16185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5206_16195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5206_16200	COG2813	Specifically methylates the guanine in position
E5206_16205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E5206_16210	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E5206_16215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5206_16220	COG2137	regulation of response to DNA damage stimulus
E5206_16225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E5206_16240	COG1396	sequence-specific DNA binding
E5206_16245	COG1058	Belongs to the CinA family
E5206_16245	COG1546	Belongs to the CinA family
E5206_16255	COG1674	ftsk spoiiie
E5206_16260	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E5206_16265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5206_16290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E5206_16300	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5206_16335	COG0612	Peptidase, M16
E5206_16340	COG1185	polyribonucleotide nucleotidyltransferase activity
E5206_16345	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E5206_16355	COG3483	tryptophan 2,3-dioxygenase activity
E5206_16420	COG3118	belongs to the thioredoxin family
E5206_16425	COG0590	tRNA wobble adenosine to inosine editing
E5206_16430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5206_16435	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E5206_16450	COG0779	Required for maturation of 30S ribosomal subunits
E5206_16465	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
E5206_16475	COG3383	formate dehydrogenase (NAD+) activity
E5206_16490	COG0442	prolyl-tRNA aminoacylation
E5206_16500	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E5206_16520	COG0750	zinc metalloprotease
E5206_16525	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E5206_16555	COG1960	acyl-CoA dehydrogenase activity
E5206_16565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5206_16575	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5206_16580	COG0022	dehydrogenase e1 component
E5206_16595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5206_16605	COG3275	phosphorelay sensor kinase activity
E5206_16610	COG3279	Response regulator of the LytR AlgR family
E5206_16620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5206_16630	COG0575	Belongs to the CDS family
E5206_16635	COG0233	cytoplasmic translational termination
E5206_16640	COG0528	UMP kinase activity
E5206_16645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E5206_16650	COG0052	Belongs to the universal ribosomal protein uS2 family
E5206_16670	COG0297	glycogen (starch) synthase activity
E5206_16680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5206_16690	COG2814	Major facilitator Superfamily
E5206_16710	COG0358	DNA primase activity
E5206_16750	COG0423	glycine-tRNA ligase activity
E5206_16765	COG0400	carboxylic ester hydrolase activity
E5206_16780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5206_16785	COG2873	o-acetylhomoserine
E5206_16815	COG0588	phosphoglycerate mutase activity
E5206_16825	COG1228	amidohydrolase
E5206_16840	COG1063	alcohol dehydrogenase
E5206_16860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5206_16865	COG0154	amidase activity
E5206_16870	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5206_16875	COG2851	Citrate transporter
E5206_16880	COG2205	protein histidine kinase activity
E5206_16900	COG0483	inositol monophosphate 1-phosphatase activity
E5206_16905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5206_16910	COG0631	protein serine/threonine phosphatase activity
E5206_16925	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E5206_16925	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E5206_16930	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_16935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5206_16965	COG2409	Drug exporters of the RND superfamily
E5206_16980	COG0424	maF-like protein
E5206_16985	COG4770	biotin carboxylase activity
E5206_16995	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5206_17005	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E5206_17010	COG0477	Major facilitator Superfamily
E5206_17015	COG2223	nitrite transmembrane transporter activity
E5206_17020	COG0243	molybdopterin cofactor binding
E5206_17065	COG1959	2 iron, 2 sulfur cluster binding
E5206_17070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5206_17080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5206_17100	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E5206_17110	COG1988	membrane-bound metal-dependent
E5206_17135	COG1215	transferase activity, transferring glycosyl groups
E5206_17150	COG3979	chitinase
E5206_17160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5206_17170	COG0822	iron-sulfur transferase activity
E5206_17190	COG2197	response regulator
E5206_17200	COG0193	aminoacyl-tRNA hydrolase activity
E5206_17205	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E5206_17215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5206_17225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5206_17235	COG1028	Short-chain dehydrogenase reductase Sdr
E5206_17240	COG1309	transcriptional regulator
E5206_17245	COG0488	(ABC) transporter
E5206_17250	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E5206_17255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5206_17260	COG3583	domain protein
E5206_17265	COG0084	hydrolase, TatD family'
E5206_17270	COG0714	Associated with various cellular activities
E5206_17310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E5206_17355	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E5206_17360	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E5206_17365	COG1316	TRANSCRIPTIONal
E5206_17370	COG1482	cell wall glycoprotein biosynthetic process
E5206_17385	COG1494	fructose-1,6-bisphosphatase
E5206_17395	COG0288	reversible hydration of carbon dioxide
E5206_17400	COG0114	fumarate hydratase activity
E5206_17430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E5206_17435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5206_17445	COG1331	Highly conserved protein containing a thioredoxin domain
E5206_17455	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E5206_17465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5206_17475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5206_17485	COG2017	converts alpha-aldose to the beta-anomer
E5206_17490	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E5206_17495	COG0183	Belongs to the thiolase family
E5206_17505	COG0559	Belongs to the binding-protein-dependent transport system permease family
E5206_17540	COG1252	NADH dehydrogenase
E5206_17560	COG0148	phosphopyruvate hydratase activity
E5206_17565	COG3956	TIGRFAM MazG family protein
E5206_17570	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5206_17575	COG0586	Pfam SNARE associated Golgi protein
E5206_17615	COG2130	NADP-dependent
E5206_17620	COG1764	response to oxidative stress
E5206_17625	COG1846	Transcriptional regulator
E5206_17630	COG1473	amidohydrolase
E5206_17630	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E5206_17640	COG2009	succinate dehydrogenase
E5206_17655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5206_17675	COG0180	Tryptophanyl-tRNA synthetase
E5206_17690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5206_17695	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5206_17710	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E5206_17720	COG0531	amino acid
E5206_17740	COG1129	ABC transporter
E5206_17750	COG4213	ABC transporter substrate-binding protein
E5206_17760	COG1136	(ABC) transporter
E5206_17780	COG2838	Isocitrate dehydrogenase
E5206_17785	COG0138	bifunctional purine biosynthesis protein purh
E5206_17790	COG0477	Major facilitator Superfamily
E5206_17830	COG2268	Band 7 protein
E5206_17845	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E5206_17890	COG1278	Cold shock
E5206_17915	COG4942	peptidase
E5206_17940	COG1063	alcohol dehydrogenase
E5206_17945	COG2072	flavoprotein involved in K transport
E5206_17965	COG1204	response to ionizing radiation
E5206_18000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5206_18035	COG3177	Filamentation induced by cAMP protein fic
E5206_18045	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E5206_18065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5206_18075	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
E5206_18080	COG0121	glutamine amidotransferase
E5206_18085	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E5206_18095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5206_18105	COG0477	Major facilitator Superfamily
E5206_18145	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5206_18150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5206_18160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5206_18170	COG3290	protein histidine kinase activity
E5206_18175	COG4565	transcriptional regulatory protein
E5206_18190	COG2368	4-hydroxyphenylacetate
E5206_18195	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E5206_18220	COG1116	anion transmembrane transporter activity
E5206_18225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5206_18230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5206_18240	COG1012	belongs to the aldehyde dehydrogenase family
E5206_18265	COG0477	Major facilitator Superfamily
E5206_18275	COG1254	Belongs to the acylphosphatase family
E5206_18285	COG4152	abc transporter atp-binding protein
E5206_18310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5206_18335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5206_18370	COG1902	pentaerythritol trinitrate reductase activity
E5206_18385	COG2124	cytochrome p450
E5206_18400	COG1309	transcriptional regulator
E5206_18415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5206_18440	COG1609	Transcriptional regulator
E5206_18470	COG1401	restriction endodeoxyribonuclease activity
E5206_18505	COG0028	Belongs to the TPP enzyme family
E5206_18525	COG1396	sequence-specific DNA binding
E5206_18565	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E5206_18570	COG0673	inositol 2-dehydrogenase activity
E5206_18575	COG0673	inositol 2-dehydrogenase activity
E5206_18580	COG0673	inositol 2-dehydrogenase activity
E5206_18590	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5206_18605	COG3718	enzyme involved in inositol metabolism
E5206_18610	COG2814	Major facilitator Superfamily
E5206_18615	COG1846	Transcriptional regulator
E5206_18620	COG1082	Xylose isomerase domain protein TIM barrel
E5206_18625	COG0673	inositol 2-dehydrogenase activity
E5206_18640	COG3962	Belongs to the TPP enzyme family
E5206_18650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5206_18655	COG1942	4-Oxalocrotonate Tautomerase
E5206_18660	COG0640	Transcriptional regulator
E5206_18675	COG0045	succinate-CoA ligase (ADP-forming) activity
E5206_18685	COG0483	inositol monophosphate 1-phosphatase activity
E5206_18715	COG3979	chitinase
E5206_18740	COG1132	(ABC) transporter
E5206_18745	COG0488	(ABC) transporter
E5206_18770	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E5206_18775	COG1058	Belongs to the CinA family
E5206_18775	COG1546	Belongs to the CinA family
E5206_18800	COG0739	heme binding
E5206_18815	COG2814	Major facilitator Superfamily
E5206_18825	COG1278	Cold shock
E5206_18850	COG0745	RESPONSE REGULATOR receiver
E5206_18855	COG2205	protein histidine kinase activity
E5206_18870	COG0459	protein refolding
E5206_18880	COG1278	Cold shock
E5206_18895	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E5206_18915	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
E5206_18925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5206_18930	COG0509	glycine decarboxylation via glycine cleavage system
E5206_18935	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E5206_18940	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5206_18940	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5206_18950	COG0477	Major facilitator Superfamily
E5206_18955	COG0783	Belongs to the Dps family
E5206_18980	COG2271	Major facilitator Superfamily
E5206_19000	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E5206_19010	COG3842	ATPase activity
E5206_19020	COG0277	FAD linked oxidase domain protein
E5206_19045	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E5206_19055	COG0366	Alpha amylase catalytic
E5206_19090	COG0215	cysteine-tRNA ligase activity
E5206_19100	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E5206_19105	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E5206_19125	COG5002	protein histidine kinase activity
E5206_19135	COG0588	phosphoglycerate mutase activity