locus-tag	class	description
ART_0007	COG0647	UMP catabolic process
ART_0010	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ART_0011	COG0497	DNA recombination
ART_0012	COG0504	CTP synthase activity
ART_0018	COG0251	oxidation-reduction process
ART_0019	COG1414	Transcriptional regulator
ART_0022	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ART_0027	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ART_0028	COG2079	MmgE PrpD family protein
ART_0031	COG1280	lysine exporter protein (LysE YggA)
ART_0033	COG0488	(ABC) transporter
ART_0039	COG1619	proteins homologs of microcin C7 resistance protein MccF
ART_0040	COG1309	transcriptional regulator
ART_0045	COG3290	protein histidine kinase activity
ART_0046	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ART_0047	COG0277	FAD linked oxidase domain protein
ART_0048	COG0673	inositol 2-dehydrogenase activity
ART_0050	COG0673	inositol 2-dehydrogenase activity
ART_0052	COG1175	transmembrane transport
ART_0058	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ART_0059	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ART_0062	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ART_0065	COG1160	GTP binding
ART_0069	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ART_0077	COG1960	acyl-CoA dehydrogenase activity
ART_0081	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ART_0082	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ART_0085	COG0509	glycine decarboxylation via glycine cleavage system
ART_0086	COG1716	ATPase activity
ART_0091	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ART_0091	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ART_0092	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ART_0094	COG1940	carbohydrate kinase activity
ART_0098	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ART_0099	COG0515	serine threonine protein kinase
ART_0099	COG2815	serine threonine protein kinase
ART_0100	COG1388	LysM domain
ART_0100	COG3942	CHAP domain
ART_0106	COG2001	Belongs to the MraZ family
ART_0107	COG0275	rRNA processing
ART_0109	COG0768	penicillin binding
ART_0112	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ART_0113	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ART_0115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ART_0116	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ART_0118	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ART_0120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ART_0121	COG1799	cell septum assembly
ART_0123	COG3599	regulation of cell shape
ART_0125	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ART_0129	COG0587	DNA-directed DNA polymerase activity
ART_0131	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ART_0132	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ART_0133	COG1028	Short-chain dehydrogenase reductase Sdr
ART_0137	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ART_0138	COG0174	glutamine synthetase
ART_0139	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ART_0141	COG3119	arylsulfatase activity
ART_0142	COG0765	amino acid transport
ART_0143	COG1126	abc transporter atp-binding protein
ART_0144	COG2066	Belongs to the glutaminase family
ART_0196	COG0305	Participates in initiation and elongation during chromosome replication
ART_0204	COG4974	Belongs to the 'phage' integrase family
ART_0208	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ART_0209	COG0321	lipoyl(octanoyl) transferase activity
ART_0214	COG0508	dehydrogenase complex catalyzes the overall conversion of
ART_0215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ART_0216	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ART_0217	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ART_0220	COG2318	DinB family
ART_0222	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ART_0223	COG2197	response regulator
ART_0226	COG0187	DNA topoisomerase II activity
ART_0227	COG0501	Belongs to the peptidase M48B family
ART_0229	COG1271	oxidase subunit
ART_0230	COG1294	oxidase, subunit
ART_0231	COG4988	ABC transporter
ART_0235	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ART_0242	COG0756	dUTP diphosphatase activity
ART_0247	COG0569	domain protein
ART_0248	COG0531	amino acid
ART_0249	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ART_0251	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ART_0256	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ART_0259	COG0667	Aldo Keto reductase
ART_0261	COG1024	Enoyl-CoA hydratase
ART_0261	COG1250	3-hydroxyacyl-CoA dehydrogenase
ART_0262	COG0183	Belongs to the thiolase family
ART_0263	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ART_0269	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ART_0272	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ART_0275	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ART_0278	COG0242	peptide deformylase activity
ART_0279	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ART_0281	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ART_0286	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ART_0287	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ART_0288	COG0140	phosphoribosyl-ATP diphosphatase activity
ART_0289	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ART_0290	COG0107	imidazoleglycerol-phosphate synthase activity
ART_0292	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ART_0296	COG0134	indole-3-glycerol-phosphate synthase activity
ART_0297	COG0133	tryptophan synthase activity
ART_0298	COG0159	tryptophan synthase activity
ART_0299	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ART_0300	COG0070	glutamate synthase
ART_0300	COG0069	glutamate synthase activity
ART_0300	COG0067	glutamate synthase
ART_0303	COG2826	transposase and inactivated derivatives, IS30 family
ART_0313	COG1028	Short-chain dehydrogenase reductase Sdr
ART_0319	COG0783	Belongs to the Dps family
ART_0322	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ART_0335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ART_0337	COG3959	Transketolase, thiamine diphosphate binding domain
ART_0338	COG0508	dehydrogenase complex catalyzes the overall conversion of
ART_0339	COG0022	dehydrogenase e1 component
ART_0340	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ART_0343	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ART_0344	COG1053	succinate dehydrogenase
ART_0353	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ART_0354	COG0589	response to stress
ART_0378	COG0604	alcohol dehydrogenase
ART_0381	COG0300	oxidoreductase activity
ART_0389	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ART_0391	COG0019	diaminopimelate decarboxylase activity
ART_0395	COG1064	alcohol dehydrogenase
ART_0403	COG1053	succinate dehydrogenase
ART_0404	COG0783	Belongs to the Dps family
ART_0413	COG0300	oxidoreductase activity
ART_0414	COG2072	flavoprotein involved in K transport
ART_0416	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ART_0417	COG1854	S-ribosylhomocysteine lyase activity
ART_0419	COG0387	Pfam Sodium calcium exchanger
ART_0420	COG0454	-acetyltransferase
ART_0434	COG0488	(ABC) transporter
ART_0435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ART_0438	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ART_0439	COG0667	Aldo Keto reductase
ART_0442	COG1473	amidohydrolase
ART_0445	COG1473	amidohydrolase
ART_0448	COG1053	succinate dehydrogenase
ART_0451	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ART_0456	COG0318	PFAM AMP-dependent synthetase and ligase
ART_0459	COG1136	(ABC) transporter
ART_0459	COG0577	efflux transmembrane transporter activity
ART_0460	COG4585	Histidine kinase
ART_0461	COG2197	response regulator
ART_0466	COG2197	response regulator
ART_0476	COG1132	(ABC) transporter
ART_0477	COG1132	(ABC) transporter
ART_0488	COG0667	Aldo Keto reductase
ART_0489	COG0667	Aldo Keto reductase
ART_0494	COG1902	pentaerythritol trinitrate reductase activity
ART_0511	COG2130	NADP-dependent
ART_0513	COG0832	Belongs to the urease beta subunit family
ART_0514	COG0804	urea catabolic process
ART_0515	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
ART_0516	COG0830	nickel cation binding
ART_0517	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ART_0518	COG0829	nickel cation binding
ART_0519	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ART_0523	COG1902	pentaerythritol trinitrate reductase activity
ART_0526	COG0833	amino acid
ART_0527	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ART_0530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ART_0531	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ART_0536	COG4213	ABC transporter substrate-binding protein
ART_0538	COG4214	carbohydrate transport
ART_0539	COG3142	Participates in the control of copper homeostasis
ART_0545	COG1162	GTPase activity
ART_0554	COG0300	oxidoreductase activity
ART_0557	COG2197	response regulator
ART_0558	COG3153	acetyltransferase
ART_0562	COG4762	Protein conserved in bacteria
ART_0567	COG4106	trans-aconitate 2-methyltransferase activity
ART_0570	COG1725	Transcriptional regulator
ART_0573	COG1335	isochorismatase
ART_0593	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ART_0602	COG0583	DNA-binding transcription factor activity
ART_0614	COG2197	response regulator
ART_0616	COG2367	Beta-lactamase
ART_0618	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ART_0624	COG0542	response to heat
ART_0639	COG4115	mRNA cleavage
ART_0640	COG2161	toxin-antitoxin pair type II binding
ART_0641	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ART_0647	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ART_0649	COG0242	peptide deformylase activity
ART_0650	COG2226	methyltransferase
ART_0651	COG2364	Membrane
ART_0656	COG1216	Glycosyl transferase, family 2
ART_0657	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ART_0658	COG4581	dead DEAH box helicase
ART_0659	COG0805	protein transport
ART_0660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ART_0666	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ART_0667	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ART_0668	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ART_0671	COG4122	O-methyltransferase activity
ART_0672	COG1222	aaa ATPase
ART_0675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ART_0678	COG0215	cysteine-tRNA ligase activity
ART_0679	COG1968	undecaprenyl-diphosphatase activity
ART_0680	COG0667	Aldo Keto reductase
ART_0684	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ART_0688	COG1028	Short-chain dehydrogenase reductase Sdr
ART_0689	COG0183	Belongs to the thiolase family
ART_0692	COG0297	glycogen (starch) synthase activity
ART_0693	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ART_0696	COG2855	membrane
ART_0699	COG0095	Lipoate-protein ligase
ART_0700	COG0254	rRNA binding
ART_0702	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ART_0704	COG1119	ATPase activity
ART_0705	COG0560	Phosphoserine phosphatase
ART_0705	COG3830	Belongs to the UPF0237 family
ART_0706	COG1028	Short-chain dehydrogenase reductase Sdr
ART_0708	COG1028	Short-chain dehydrogenase reductase Sdr
ART_0713	COG0488	(ABC) transporter
ART_0714	COG1268	BioY protein
ART_0715	COG1122	ATPase activity
ART_0717	COG0183	Belongs to the thiolase family
ART_0718	COG0318	PFAM AMP-dependent synthetase and ligase
ART_0720	COG2151	metal-sulfur cluster biosynthetic enzyme
ART_0721	COG0396	ATPase activity
ART_0730	COG0109	protoheme IX farnesyltransferase activity
ART_0732	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ART_0733	COG0166	Belongs to the GPI family
ART_0736	COG0363	glucosamine-6-phosphate deaminase activity
ART_0737	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ART_0738	COG0149	triose-phosphate isomerase activity
ART_0739	COG0126	phosphoglycerate kinase activity
ART_0740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ART_0743	COG1481	regulation of sporulation
ART_0744	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ART_0745	COG1660	Displays ATPase and GTPase activities
ART_0746	COG0322	excinuclease ABC activity
ART_0754	COG3550	peptidyl-serine autophosphorylation
ART_0756	COG4106	trans-aconitate 2-methyltransferase activity
ART_0760	COG4989	oxidoreductase activity
ART_0762	COG0556	nucleotide-excision repair
ART_0764	COG0237	dephospho-CoA kinase activity
ART_0764	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ART_0765	COG0277	FAD linked oxidase domain protein
ART_0766	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ART_0766	COG1672	PFAM Archaeal ATPase
ART_0767	COG1739	Uncharacterized protein family UPF0029
ART_0768	COG3152	Membrane
ART_0771	COG0539	negative regulation of cytoplasmic translation
ART_0774	COG4552	Acetyltransferase involved in intracellular survival and related
ART_0776	COG2050	protein possibly involved in aromatic compounds catabolism
ART_0784	COG0318	PFAM AMP-dependent synthetase and ligase
ART_0785	COG2261	transglycosylase associated protein
ART_0791	COG0673	inositol 2-dehydrogenase activity
ART_0792	COG1609	Transcriptional regulator
ART_0796	COG0109	protoheme IX farnesyltransferase activity
ART_0799	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ART_0800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ART_0801	COG0009	L-threonylcarbamoyladenylate synthase
ART_0802	COG0783	Belongs to the Dps family
ART_0803	COG1028	Short-chain dehydrogenase reductase Sdr
ART_0804	COG1643	Atp-dependent helicase
ART_0807	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ART_0813	COG2268	Band 7 protein
ART_0817	COG2197	response regulator
ART_0823	COG2217	Heavy metal translocating P-type atpase
ART_0826	COG2132	Multicopper oxidase
ART_0831	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ART_0840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ART_0841	COG0135	phosphoribosylanthranilate isomerase activity
ART_0847	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ART_0848	COG3119	arylsulfatase activity
ART_0850	COG0025	NhaP-type Na H and K H
ART_0851	COG2814	Major facilitator Superfamily
ART_0854	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ART_0855	COG1121	(ABC) transporter
ART_0859	COG3119	arylsulfatase activity
ART_0861	COG0395	ABC-type sugar transport system, permease component
ART_0864	COG1609	Transcriptional regulator
ART_0872	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ART_0873	COG1845	cytochrome c oxidase, subunit III
ART_0874	COG2010	Cytochrome c
ART_0875	COG0723	plastoquinol--plastocyanin reductase activity
ART_0876	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ART_0881	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ART_0882	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ART_0886	COG0667	Aldo Keto reductase
ART_0887	COG0167	dihydroorotate dehydrogenase activity
ART_0890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ART_0891	COG1381	Involved in DNA repair and RecF pathway recombination
ART_0892	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ART_0893	COG3590	peptidase
ART_0895	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ART_0897	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ART_0901	COG0484	heat shock protein binding
ART_0902	COG1420	regulation of RNA biosynthetic process
ART_0905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ART_0906	COG0481	GTPase activity
ART_0908	COG0268	Binds directly to 16S ribosomal RNA
ART_0910	COG3387	PFAM Glycoside hydrolase 15-related
ART_0911	COG1028	Short-chain dehydrogenase reductase Sdr
ART_0917	COG0028	Belongs to the TPP enzyme family
ART_0929	COG3237	CsbD-like
ART_0934	COG1307	EDD domain protein, DegV family
ART_0935	COG0495	leucyl-tRNA aminoacylation
ART_0936	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ART_0937	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ART_0938	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ART_0939	COG2390	Transcriptional regulator
ART_0940	COG0656	L-ascorbic acid biosynthetic process
ART_0945	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ART_0946	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ART_0948	COG1758	RNA polymerase activity
ART_0949	COG0194	GDP metabolic process
ART_0950	COG0194	GDP metabolic process
ART_0951	COG0284	orotidine-5'-phosphate decarboxylase activity
ART_0952	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ART_0953	COG0505	Belongs to the CarA family
ART_0955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ART_0956	COG0540	Belongs to the ATCase OTCase family
ART_0957	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ART_0959	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ART_0960	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ART_0962	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ART_0963	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ART_0964	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ART_0965	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ART_0967	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ART_0968	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ART_0971	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ART_0976	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ART_0977	COG0124	histidyl-tRNA synthetase
ART_0979	COG1196	nuclear chromosome segregation
ART_0981	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ART_0982	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ART_0983	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ART_0985	COG2255	four-way junction helicase activity
ART_0986	COG0632	four-way junction helicase activity
ART_0987	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ART_0988	COG0217	transcriptional regulatory protein
ART_0989	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ART_0990	COG0367	asparagine synthase
ART_0991	COG0456	acetyltransferase
ART_0991	COG0454	-acetyltransferase
ART_0992	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ART_0993	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ART_0996	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ART_0997	COG0587	DNA-directed DNA polymerase activity
ART_0999	COG0456	acetyltransferase
ART_1001	COG2135	peptidase activity
ART_1002	COG0180	Tryptophanyl-tRNA synthetase
ART_1010	COG0318	PFAM AMP-dependent synthetase and ligase
ART_1012	COG4682	membrane
ART_1013	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ART_1014	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ART_1015	COG1780	Probably involved in ribonucleotide reductase function
ART_1017	COG0738	Major facilitator superfamily
ART_1018	COG3226	Transcriptional regulator
ART_1019	COG0110	maltose O-acetyltransferase activity
ART_1020	COG0583	DNA-binding transcription factor activity
ART_1021	COG1012	belongs to the aldehyde dehydrogenase family
ART_1026	COG2890	protein-(glutamine-N5) methyltransferase activity
ART_1027	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ART_1028	COG3012	SEC-C Motif Domain Protein
ART_1029	COG2188	Transcriptional regulator
ART_1032	COG0799	negative regulation of ribosome biogenesis
ART_1034	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ART_1036	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ART_1040	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ART_1041	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ART_1043	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ART_1045	COG0351	phosphomethylpyrimidine kinase
ART_1045	COG0352	thiamine-phosphate diphosphorylase activity
ART_1045	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ART_1046	COG1530	ribonuclease E activity
ART_1049	COG0105	UTP biosynthetic process
ART_1051	COG0285	dihydrofolate synthase activity
ART_1052	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ART_1055	COG3189	MarR family transcriptional regulator
ART_1057	COG0525	valine-tRNA ligase activity
ART_1059	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ART_1060	COG0438	transferase activity, transferring glycosyl groups
ART_1060	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ART_1063	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ART_1064	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ART_1065	COG0740	serine-type endopeptidase activity
ART_1066	COG0740	serine-type endopeptidase activity
ART_1067	COG0544	peptidyl-prolyl cis-trans isomerase activity
ART_1069	COG0698	ribose 5-phosphate isomerase
ART_1074	COG0668	transmembrane transport
ART_1078	COG1946	Acyl-CoA thioesterase
ART_1088	COG1764	response to oxidative stress
ART_1089	COG1846	Transcriptional regulator
ART_1092	COG1064	alcohol dehydrogenase
ART_1095	COG1028	Short-chain dehydrogenase reductase Sdr
ART_1098	COG1073	alpha beta
ART_1104	COG2197	response regulator
ART_1109	COG2072	flavoprotein involved in K transport
ART_1112	COG0076	glutamate decarboxylase activity
ART_1113	COG2890	protein-(glutamine-N5) methyltransferase activity
ART_1119	COG0477	Major facilitator Superfamily
ART_1121	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ART_1122	COG2267	carboxylic ester hydrolase activity
ART_1127	COG3022	response to hydroperoxide
ART_1128	COG0346	lactoylglutathione lyase activity
ART_1130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ART_1131	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ART_1133	COG1045	serine acetyltransferase
ART_1136	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ART_1137	COG1063	alcohol dehydrogenase
ART_1138	COG1028	Short-chain dehydrogenase reductase Sdr
ART_1141	COG0477	Major facilitator Superfamily
ART_1142	COG1414	Transcriptional regulator
ART_1144	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ART_1148	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ART_1151	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ART_1152	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ART_1153	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ART_1155	COG4974	Belongs to the 'phage' integrase family
ART_1156	COG1316	TRANSCRIPTIONal
ART_1157	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ART_1157	COG0758	DNA mediated transformation
ART_1158	COG0606	chelatase, subunit chli
ART_1159	COG0792	nuclease activity
ART_1161	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ART_1163	COG0681	Belongs to the peptidase S26 family
ART_1164	COG0335	large ribosomal subunit rRNA binding
ART_1165	COG0336	Belongs to the RNA methyltransferase TrmD family
ART_1166	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ART_1167	COG1837	Belongs to the UPF0109 family
ART_1168	COG0228	four-way junction DNA binding
ART_1171	COG2514	catechol 2,3-dioxygenase activity
ART_1178	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ART_1185	COG2814	Major facilitator Superfamily
ART_1188	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ART_1189	COG0318	PFAM AMP-dependent synthetase and ligase
ART_1190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ART_1194	COG0584	glycerophosphoryl diester phosphodiesterase
ART_1196	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ART_1197	COG0571	ribonuclease III activity
ART_1198	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ART_1201	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ART_1205	COG0673	inositol 2-dehydrogenase activity
ART_1207	COG0742	ribosomal rna small subunit methyltransferase
ART_1208	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ART_1216	COG0798	PFAM Bile acid sodium symporter
ART_1217	COG0640	Transcriptional regulator
ART_1224	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ART_1226	COG2337	Toxic component of a toxin-antitoxin (TA) module
ART_1227	COG1960	acyl-CoA dehydrogenase activity
ART_1228	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ART_1229	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ART_1231	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ART_1232	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ART_1233	COG1695	Transcriptional regulator
ART_1243	COG0438	transferase activity, transferring glycosyl groups
ART_1245	COG1215	transferase activity, transferring glycosyl groups
ART_1245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ART_1249	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ART_1250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ART_1251	COG0438	transferase activity, transferring glycosyl groups
ART_1255	COG0110	maltose O-acetyltransferase activity
ART_1256	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ART_1259	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ART_1260	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ART_1260	COG0463	Glycosyl transferase, family 2
ART_1263	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ART_1263	COG0463	Glycosyl transferase, family 2
ART_1263	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ART_1263	COG0463	Glycosyl transferase, family 2
ART_1264	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ART_1266	COG1134	teichoic acid transport
ART_1266	COG1388	LysM domain
ART_1271	COG1316	TRANSCRIPTIONal
ART_1275	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ART_1276	COG4821	SIS domain
ART_1277	COG0363	glucosamine-6-phosphate deaminase activity
ART_1282	COG0463	Glycosyl transferase, family 2
ART_1284	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ART_1286	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ART_1288	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ART_1293	COG1181	Belongs to the D-alanine--D-alanine ligase family
ART_1294	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ART_1296	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ART_1301	COG0066	3-isopropylmalate dehydratase activity
ART_1302	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ART_1303	COG1414	Transcriptional regulator
ART_1304	COG2340	Cysteine-rich secretory protein family
ART_1314	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ART_1321	COG1113	amino acid transport
ART_1324	COG2197	response regulator
ART_1325	COG4585	Histidine kinase
ART_1327	COG0179	Fumarylacetoacetate (FAA) hydrolase
ART_1328	COG2116	formate transmembrane transporter activity
ART_1330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ART_1332	COG2814	Major facilitator Superfamily
ART_1333	COG0473	3-isopropylmalate dehydrogenase activity
ART_1334	COG4585	Histidine kinase
ART_1335	COG2197	response regulator
ART_1337	COG1175	transmembrane transport
ART_1338	COG1653	transport
ART_1340	COG2186	Transcriptional regulator
ART_1344	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ART_1345	COG0577	efflux transmembrane transporter activity
ART_1345	COG1136	(ABC) transporter
ART_1349	COG1028	Short-chain dehydrogenase reductase Sdr
ART_1350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ART_1359	COG3119	arylsulfatase activity
ART_1360	COG1940	carbohydrate kinase activity
ART_1362	COG0395	ABC-type sugar transport system, permease component
ART_1363	COG1175	transmembrane transport
ART_1365	COG1940	carbohydrate kinase activity
ART_1368	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ART_1369	COG0440	acetolactate synthase activity
ART_1371	COG0129	dihydroxy-acid dehydratase activity
ART_1373	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ART_1376	COG0747	negative chemotaxis
ART_1377	COG0579	oxidoreductase
ART_1378	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ART_1381	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ART_1382	COG1846	Transcriptional regulator
ART_1386	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ART_1387	COG0179	Fumarylacetoacetate (FAA) hydrolase
ART_1391	COG2205	protein histidine kinase activity
ART_1397	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ART_1398	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ART_1400	COG1113	amino acid transport
ART_1403	COG0419	ATPase involved in DNA repair
ART_1404	COG0420	3'-5' exonuclease activity
ART_1408	COG2149	membrane
ART_1416	COG1131	(ABC) transporter
ART_1417	COG2188	Transcriptional regulator
ART_1418	COG0586	Pfam SNARE associated Golgi protein
ART_1419	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ART_1420	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ART_1423	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ART_1425	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ART_1426	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ART_1427	COG1335	isochorismatase
ART_1430	COG0363	glucosamine-6-phosphate deaminase activity
ART_1433	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ART_1435	COG0628	permease
ART_1438	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
ART_1439	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ART_1440	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ART_1443	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ART_1444	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ART_1445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ART_1446	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ART_1447	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ART_1448	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ART_1449	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ART_1450	COG0356	it plays a direct role in the translocation of protons across the membrane
ART_1452	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ART_1453	COG1086	Polysaccharide biosynthesis protein
ART_1455	COG1216	Glycosyl transferase, family 2
ART_1457	COG0009	L-threonylcarbamoyladenylate synthase
ART_1458	COG2890	protein-(glutamine-N5) methyltransferase activity
ART_1459	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ART_1461	COG0083	homoserine kinase activity
ART_1462	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ART_1463	COG0460	homoserine dehydrogenase
ART_1464	COG0019	diaminopimelate decarboxylase activity
ART_1465	COG0018	arginyl-trna synthetase
ART_1469	COG1136	(ABC) transporter
ART_1469	COG4591	ABC-type transport system involved in lipoprotein release permease component
ART_1471	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ART_1472	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ART_1477	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ART_1481	COG1414	Transcriptional regulator
ART_1483	COG0477	Major facilitator Superfamily
ART_1484	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ART_1489	COG1760	l-serine dehydratase
ART_1492	COG0697	spore germination
ART_1493	COG1846	Transcriptional regulator
ART_1495	COG1643	Atp-dependent helicase
ART_1496	COG2161	toxin-antitoxin pair type II binding
ART_1497	COG4115	mRNA cleavage
ART_1501	COG1028	Short-chain dehydrogenase reductase Sdr
ART_1503	COG0537	adenosine 5'-monophosphoramidase activity
ART_1504	COG1064	alcohol dehydrogenase
ART_1506	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ART_1507	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ART_1510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ART_1511	COG1120	ATPase activity
ART_1512	COG0803	Belongs to the bacterial solute-binding protein 9 family
ART_1514	COG1253	flavin adenine dinucleotide binding
ART_1516	COG0789	Transcriptional regulator
ART_1517	COG3265	gluconokinase activity
ART_1518	COG2186	Transcriptional regulator
ART_1521	COG1175	transmembrane transport
ART_1523	COG4948	Mandelate Racemase Muconate Lactonizing
ART_1524	COG3265	gluconokinase activity
ART_1525	COG4948	Mandelate Racemase Muconate Lactonizing
ART_1526	COG0246	Mannitol dehydrogenase
ART_1527	COG1904	glucuronate isomerase
ART_1528	COG1609	Transcriptional regulator
ART_1531	COG0673	inositol 2-dehydrogenase activity
ART_1533	COG1609	Transcriptional regulator
ART_1534	COG1609	Transcriptional regulator
ART_1536	COG1175	transmembrane transport
ART_1537	COG0395	ABC-type sugar transport system, permease component
ART_1540	COG0567	Dehydrogenase, E1 component
ART_1540	COG0508	dehydrogenase complex catalyzes the overall conversion of
ART_1547	COG1595	DNA-templated transcription, initiation
ART_1549	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ART_1551	COG0483	inositol monophosphate 1-phosphatase activity
ART_1552	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ART_1555	COG1321	iron dependent repressor
ART_1556	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ART_1564	COG1760	l-serine dehydratase
ART_1631	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ART_1634	COG2884	Cell division ATP-binding protein ftsE
ART_1635	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ART_1653	COG1132	(ABC) transporter
ART_1662	COG0673	inositol 2-dehydrogenase activity
ART_1667	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ART_1669	COG1088	dTDP-glucose 4,6-dehydratase activity
ART_1673	COG0463	Glycosyl transferase, family 2
ART_1677	COG2755	lipolytic protein G-D-S-L family
ART_1677	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ART_1679	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ART_1683	COG1216	Glycosyl transferase, family 2
ART_1686	COG1674	ftsk spoiiie
ART_1690	COG2902	Dehydrogenase
ART_1697	COG0653	protein targeting
ART_1698	COG3214	Protein conserved in bacteria
ART_1699	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ART_1700	COG1040	competence protein
ART_1702	COG5401	PFAM Sporulation and spore germination
ART_1703	COG5002	protein histidine kinase activity
ART_1703	COG5000	phosphorelay sensor kinase activity
ART_1704	COG0745	RESPONSE REGULATOR receiver
ART_1708	COG0714	Associated with various cellular activities
ART_1714	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ART_1715	COG0601	transmembrane transport
ART_1719	COG0482	sulfurtransferase activity
ART_1723	COG0302	gtp cyclohydrolase
ART_1725	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ART_1727	COG0484	heat shock protein binding
ART_1728	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ART_1731	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ART_1732	COG2086	electron transfer activity
ART_1735	COG1136	(ABC) transporter
ART_1737	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ART_1741	COG1842	Phage shock protein A
ART_1742	COG0656	L-ascorbic acid biosynthetic process
ART_1743	COG3585	molybdate ion transport
ART_1751	COG1960	acyl-CoA dehydrogenase activity
ART_1753	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ART_1755	COG1846	Transcriptional regulator
ART_1757	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ART_1758	COG0318	PFAM AMP-dependent synthetase and ligase
ART_1759	COG1024	Enoyl-CoA hydratase
ART_1760	COG1250	3-hydroxyacyl-CoA dehydrogenase
ART_1760	COG1024	Enoyl-CoA hydratase
ART_1761	COG0183	Belongs to the thiolase family
ART_1762	COG1960	acyl-CoA dehydrogenase activity
ART_1763	COG1024	Enoyl-CoA hydratase
ART_1766	COG1028	Short-chain dehydrogenase reductase Sdr
ART_1771	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ART_1775	COG0628	permease
ART_1778	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ART_1779	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ART_1781	COG0490	domain, Protein
ART_1781	COG0471	metal ion transport
ART_1782	COG1615	UPF0182 protein
ART_1783	COG3480	Lon protease (S16) C-terminal proteolytic domain
ART_1788	COG2816	NAD+ diphosphatase activity
ART_1796	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ART_1797	COG0765	amino acid transport
ART_1798	COG1126	abc transporter atp-binding protein
ART_1802	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ART_1805	COG0181	hydroxymethylbilane synthase activity
ART_1809	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ART_1810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ART_1813	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ART_1814	COG2011	ABC-type metal ion transport system permease component
ART_1815	COG1464	Belongs to the NlpA lipoprotein family
ART_1820	COG2022	thiamine diphosphate biosynthetic process
ART_1823	COG0352	thiamine-phosphate diphosphorylase activity
ART_1824	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ART_1825	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ART_1832	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ART_1834	COG2072	flavoprotein involved in K transport
ART_1840	COG2207	Transcriptional regulator
ART_1853	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ART_1855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ART_1856	COG0509	glycine decarboxylation via glycine cleavage system
ART_1857	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ART_1858	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ART_1858	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ART_1859	COG1113	amino acid transport
ART_1861	COG2814	Major facilitator Superfamily
ART_1862	COG0477	Major facilitator Superfamily
ART_1863	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ART_1868	COG0513	Belongs to the DEAD box helicase family
ART_1871	COG0613	PHP domain protein
ART_1872	COG0006	proline dipeptidase activity
ART_1874	COG2239	Acts as a magnesium transporter
ART_1879	COG1595	DNA-templated transcription, initiation
ART_1883	COG2818	Glycosylase
ART_1886	COG1126	abc transporter atp-binding protein
ART_1887	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ART_1888	COG0765	amino acid transport
ART_1889	COG0765	amino acid transport
ART_1890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ART_1892	COG2171	N-acyltransferase activity
ART_1903	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ART_1904	COG4172	Belongs to the ABC transporter superfamily
ART_1906	COG0601	transmembrane transport
ART_1910	COG2197	response regulator
ART_1911	COG4585	Histidine kinase
ART_1913	COG1131	(ABC) transporter
ART_1917	COG0747	negative chemotaxis
ART_1918	COG2318	DinB family
ART_1926	COG2211	Major facilitator Superfamily
ART_1929	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ART_1930	COG2186	Transcriptional regulator
ART_1931	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ART_1937	COG0012	GTP binding
ART_1940	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ART_1942	COG1570	exodeoxyribonuclease VII activity
ART_1943	COG1722	exodeoxyribonuclease VII activity
ART_1945	COG2326	polyphosphate kinase activity
ART_1949	COG1609	Transcriptional regulator
ART_1950	COG2971	BadF BadG BcrA BcrD
ART_1951	COG2070	2-Nitropropane dioxygenase
ART_1953	COG0598	Magnesium transport protein CorA
ART_1956	COG0778	Nitroreductase
ART_1958	COG0039	L-malate dehydrogenase activity
ART_1959	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ART_1960	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ART_1964	COG1309	transcriptional regulator
ART_1965	COG1131	(ABC) transporter
ART_1969	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ART_1969	COG4499	WXG100 protein secretion system (Wss), protein YukC
ART_1971	COG0488	(ABC) transporter
ART_1973	COG0412	Dienelactone hydrolase
ART_1986	COG2186	Transcriptional regulator
ART_1989	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ART_1991	COG2160	L-arabinose isomerase activity
ART_1994	COG1609	Transcriptional regulator
ART_1996	COG2017	converts alpha-aldose to the beta-anomer
ART_2002	COG1063	alcohol dehydrogenase
ART_2025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ART_2026	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ART_2031	COG0519	Catalyzes the synthesis of GMP from XMP
ART_2031	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ART_2035	COG0516	GMP reductase activity
ART_2042	COG2217	Heavy metal translocating P-type atpase
ART_2043	COG0459	protein refolding
ART_2044	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ART_2055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ART_2056	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ART_2057	COG0671	phosphoesterase, PA-phosphatase related
ART_2059	COG0745	RESPONSE REGULATOR receiver
ART_2060	COG5002	protein histidine kinase activity
ART_2063	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ART_2064	COG0456	acetyltransferase
ART_2066	COG0802	atpase or kinase
ART_2067	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ART_2068	COG0438	transferase activity, transferring glycosyl groups
ART_2069	COG1404	Belongs to the peptidase S8 family
ART_2071	COG0395	ABC-type sugar transport system, permease component
ART_2072	COG0366	Alpha amylase catalytic
ART_2074	COG1260	myo-inositol-1-phosphate synthase
ART_2076	COG0667	Aldo Keto reductase
ART_2080	COG0736	holo-[acyl-carrier-protein] synthase activity
ART_2081	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ART_2082	COG1072	(Pantothenic acid kinase))
ART_2084	COG1970	mechanosensitive ion channel activity
ART_2085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ART_2086	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ART_2087	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ART_2088	COG0101	tRNA pseudouridine synthase activity
ART_2089	COG0203	ribosomal protein L17
ART_2090	COG0202	RNA polymerase activity
ART_2091	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ART_2092	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ART_2093	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ART_2094	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ART_2097	COG1653	transport
ART_2098	COG0395	ABC-type sugar transport system, permease component
ART_2103	COG0563	adenylate kinase activity
ART_2105	COG0200	Binds to the 23S rRNA
ART_2106	COG1841	ribosomal large subunit assembly
ART_2107	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ART_2108	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ART_2109	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ART_2110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ART_2111	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ART_2112	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ART_2113	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ART_2114	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ART_2115	COG0255	Belongs to the universal ribosomal protein uL29 family
ART_2116	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ART_2117	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ART_2118	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ART_2120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ART_2121	COG0089	rRNA binding
ART_2122	COG0088	Forms part of the polypeptide exit tunnel
ART_2123	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ART_2124	COG0051	transcription antitermination factor activity, RNA binding
ART_2129	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ART_2130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ART_2131	COG0049	tRNA binding
ART_2132	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ART_2133	COG1752	Esterase of the alpha-beta hydrolase superfamily
ART_2134	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ART_2135	COG0085	RNA polymerase activity
ART_2137	COG0183	Belongs to the thiolase family
ART_2138	COG0442	prolyl-tRNA aminoacylation
ART_2139	COG0222	ribosome binding
ART_2140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ART_2143	COG0081	regulation of translation
ART_2144	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ART_2145	COG0250	Participates in transcription elongation, termination and antitermination
ART_2148	COG0436	Aminotransferase
ART_2149	COG2197	response regulator
ART_2159	COG3485	protocatechuate 3,4-dioxygenase
ART_2162	COG0745	RESPONSE REGULATOR receiver
ART_2163	COG0456	acetyltransferase
ART_2164	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ART_2169	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ART_2173	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ART_2176	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ART_2179	COG2030	dehydratase
ART_2181	COG0477	Major facilitator Superfamily
ART_2186	COG2301	Belongs to the HpcH HpaI aldolase family
ART_2190	COG0702	epimerase
ART_2193	COG0477	Major facilitator Superfamily
ART_2197	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ART_2198	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ART_2199	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ART_2200	COG1028	Short-chain dehydrogenase reductase Sdr
ART_2201	COG0402	S-adenosylhomocysteine deaminase activity
ART_2202	COG1652	LysM domain
ART_2211	COG1012	belongs to the aldehyde dehydrogenase family
ART_2217	COG1063	alcohol dehydrogenase
ART_2219	COG2376	Dihydroxyacetone kinase
ART_2220	COG0698	ribose 5-phosphate isomerase
ART_2221	COG1028	Short-chain dehydrogenase reductase Sdr
ART_2223	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ART_2225	COG2814	Major facilitator Superfamily
ART_2233	COG1666	GTP binding
ART_2236	COG4585	Histidine kinase
ART_2237	COG0406	alpha-ribazole phosphatase activity
ART_2240	COG2826	transposase and inactivated derivatives, IS30 family
ART_2241	COG0753	catalase activity
ART_2245	COG0531	amino acid
ART_2250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ART_2257	COG1012	belongs to the aldehyde dehydrogenase family
ART_2262	COG2188	Transcriptional regulator
ART_2264	COG1648	precorrin-2 dehydrogenase activity
ART_2264	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ART_2266	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ART_2267	COG1116	anion transmembrane transporter activity
ART_2280	COG0175	sulfate reduction
ART_2281	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ART_2286	COG4152	abc transporter atp-binding protein
ART_2287	COG2860	membrane
ART_2293	COG2226	methyltransferase
ART_2294	COG1169	isochorismate synthase
ART_2295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ART_2296	COG0765	amino acid transport
ART_2298	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ART_2299	COG4948	Mandelate Racemase Muconate Lactonizing
ART_2304	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ART_2306	COG1597	lipid kinase activity
ART_2309	COG0277	FAD linked oxidase domain protein
ART_2312	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ART_2313	COG2151	metal-sulfur cluster biosynthetic enzyme
ART_2314	COG3396	Phenylacetate-CoA oxygenase
ART_2315	COG3460	Phenylacetate-CoA oxygenase
ART_2316	COG3396	Phenylacetate-CoA oxygenase
ART_2322	COG1012	belongs to the aldehyde dehydrogenase family
ART_2322	COG2030	dehydratase
ART_2323	COG1250	3-hydroxyacyl-CoA dehydrogenase
ART_2324	COG1024	Enoyl-CoA hydratase
ART_2327	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ART_2331	COG0076	glutamate decarboxylase activity
ART_2332	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ART_2333	COG0280	phosphate acetyltransferase
ART_2333	COG0857	belongs to the CobB CobQ family
ART_2340	COG0488	(ABC) transporter
ART_2345	COG0653	protein targeting
ART_2348	COG2365	Tyrosine phosphatase family
ART_2351	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ART_2363	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ART_2374	COG3012	SEC-C Motif Domain Protein
ART_2375	COG4804	nuclease activity
ART_2377	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ART_2378	COG4942	peptidase
ART_2387	COG1309	transcriptional regulator
ART_2391	COG0386	Belongs to the glutathione peroxidase family
ART_2394	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ART_2397	COG0129	dihydroxy-acid dehydratase activity
ART_2399	COG4555	ABC transporter
ART_2405	COG1012	belongs to the aldehyde dehydrogenase family
ART_2407	COG2076	Multidrug Resistance protein
ART_2408	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ART_2413	COG1846	Transcriptional regulator
ART_2422	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ART_2423	COG0047	phosphoribosylformylglycinamidine synthase activity
ART_2424	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ART_2428	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ART_2430	COG1832	CoA-binding protein
ART_2433	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ART_2434	COG1794	racemase activity, acting on amino acids and derivatives
ART_2435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ART_2436	COG1028	Short-chain dehydrogenase reductase Sdr
ART_2438	COG1028	Short-chain dehydrogenase reductase Sdr
ART_2445	COG0477	Major facilitator Superfamily
ART_2452	COG0191	fructose-bisphosphate aldolase activity
ART_2457	COG1435	thymidine kinase activity
ART_2458	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ART_2459	COG1435	thymidine kinase activity
ART_2460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ART_2461	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ART_2462	COG0800	Aldolase
ART_2463	COG4948	Mandelate Racemase Muconate Lactonizing
ART_2464	COG0395	ABC-type sugar transport system, permease component
ART_2465	COG1175	transmembrane transport
ART_2467	COG1802	Transcriptional regulator
ART_2469	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ART_2471	COG4176	ABC-type proline glycine betaine transport system permease component
ART_2472	COG0517	IMP dehydrogenase activity
ART_2472	COG4175	Glycine betaine
ART_2475	COG1609	Transcriptional regulator
ART_2488	COG0791	NLP P60 protein
ART_2488	COG1388	LysM domain
ART_2488	COG3103	Sh3 type 3 domain protein
ART_2494	COG2372	response to copper ion
ART_2495	COG2252	PERMEase
ART_2496	COG0010	Belongs to the arginase family
ART_2506	COG1819	glycosyl
ART_2511	COG3387	PFAM Glycoside hydrolase 15-related
ART_2512	COG2733	membrane
ART_2519	COG1105	Belongs to the carbohydrate kinase PfkB family
ART_2520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ART_2520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ART_2520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ART_2521	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ART_2522	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ART_2523	COG0477	Major facilitator Superfamily
ART_2524	COG4221	oxidoreductase activity
ART_2526	COG0351	phosphomethylpyrimidine kinase
ART_2527	COG1335	isochorismatase
ART_2532	COG1028	Short-chain dehydrogenase reductase Sdr
ART_2533	COG2267	carboxylic ester hydrolase activity
ART_2540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ART_2543	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ART_2547	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ART_2555	COG1461	Dihydroxyacetone kinase
ART_2556	COG2376	Dihydroxyacetone kinase
ART_2557	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ART_2558	COG3548	integral membrane protein
ART_2559	COG0542	response to heat
ART_2562	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ART_2563	COG1609	Transcriptional regulator
ART_2564	COG1957	nucleoside hydrolase
ART_2565	COG2814	Major facilitator Superfamily
ART_2566	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ART_2567	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ART_2573	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ART_2575	COG0302	gtp cyclohydrolase
ART_2576	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ART_2579	COG0037	tRNA processing
ART_2585	COG0561	phosphatase activity
ART_2586	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ART_2587	COG1597	lipid kinase activity
ART_2590	COG3104	oligopeptide transport
ART_2595	COG2233	PERMEase
ART_2599	COG1802	Transcriptional regulator
ART_2603	COG3938	Belongs to the proline racemase family
ART_2607	COG0410	ABC transporter
ART_2610	COG0559	Belongs to the binding-protein-dependent transport system permease family
ART_2612	COG1929	Belongs to the glycerate kinase type-1 family
ART_2614	COG0561	phosphatase activity
ART_2622	COG4585	Histidine kinase
ART_2636	COG1063	alcohol dehydrogenase
ART_2638	COG0477	Major facilitator Superfamily
ART_2640	COG3119	arylsulfatase activity
ART_2643	COG0395	ABC-type sugar transport system, permease component
ART_2644	COG1175	transmembrane transport
ART_2646	COG3119	arylsulfatase activity
ART_2647	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ART_2650	COG1556	Lactate utilization protein
ART_2651	COG1139	Iron-sulfur cluster binding protein
ART_2652	COG0247	lactate metabolic process
ART_2655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ART_2656	COG1012	belongs to the aldehyde dehydrogenase family
ART_2657	COG0028	Belongs to the TPP enzyme family
ART_2658	COG2508	Transcriptional regulator
ART_2659	COG0477	Major facilitator Superfamily
ART_2660	COG0251	oxidation-reduction process
ART_2661	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ART_2662	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ART_2665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ART_2666	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ART_2675	COG3853	Toxic anion resistance protein (TelA)
ART_2681	COG1358	cellular component organization or biogenesis
ART_2684	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ART_2685	COG0251	oxidation-reduction process
ART_2686	COG4172	Belongs to the ABC transporter superfamily
ART_2688	COG0601	transmembrane transport
ART_2689	COG0747	negative chemotaxis
ART_2693	COG1609	Transcriptional regulator
ART_2708	COG1362	aminopeptidase activity
ART_2710	COG2197	response regulator
ART_2711	COG4585	Histidine kinase
ART_2715	COG0738	Major facilitator superfamily
ART_2720	COG0488	(ABC) transporter
ART_2721	COG4585	Histidine kinase
ART_2722	COG2197	response regulator
ART_2723	COG4152	abc transporter atp-binding protein
ART_2728	COG2197	response regulator
ART_2730	COG0791	NLP P60 protein
ART_2731	COG2197	response regulator
ART_2732	COG3850	Histidine kinase
ART_2738	COG0406	alpha-ribazole phosphatase activity
ART_2739	COG0617	tRNA 3'-terminal CCA addition
ART_2743	COG0492	ferredoxin-NADP+ reductase activity
ART_2744	COG3118	belongs to the thioredoxin family
ART_2752	COG3547	Transposase (IS116 IS110 IS902 family)
ART_2753	COG3547	Transposase (IS116 IS110 IS902 family)
ART_2758	COG1192	Involved in chromosome partitioning
ART_2759	COG0357	Ribosomal RNA small subunit methyltransferase G
ART_2761	COG0706	membrane insertase activity
ART_2763	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ART_2765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ART_2766	COG0592	DNA-directed DNA polymerase activity
ART_2767	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ART_2768	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ART_2769	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
ART_2770	COG0187	DNA topoisomerase II activity
ART_2771	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ART_2773	COG3266	domain, Protein
ART_2778	COG0705	Rhomboid family
ART_2782	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ART_2787	COG3764	Sortase (surface protein transpeptidase)
ART_2790	COG0515	serine threonine protein kinase
ART_2791	COG0515	serine threonine protein kinase
ART_2792	COG0768	penicillin binding
ART_2795	COG1716	ATPase activity
ART_2796	COG1716	ATPase activity
ART_2808	COG0360	Binds together with S18 to 16S ribosomal RNA
ART_2810	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ART_2811	COG0359	binds to the 23S rRNA
ART_2813	COG0305	Participates in initiation and elongation during chromosome replication
ART_2814	COG0534	Mate efflux family protein
ART_2819	COG4821	SIS domain
ART_2822	COG0395	ABC-type sugar transport system, permease component
ART_2827	COG1937	Protein conserved in bacteria
ART_2830	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ART_2834	COG1063	alcohol dehydrogenase
ART_2835	COG0395	ABC-type sugar transport system, permease component
ART_2838	COG2390	Transcriptional regulator
ART_2839	COG1070	Carbohydrate kinase
ART_2841	COG0028	Belongs to the TPP enzyme family
ART_2845	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ART_2850	COG1607	acyl-coa hydrolase
ART_2852	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ART_2855	COG1950	PFAM Membrane protein of
ART_2856	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ART_2858	COG0022	dehydrogenase e1 component
ART_2859	COG0508	dehydrogenase complex catalyzes the overall conversion of
ART_2864	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ART_2866	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ART_2868	COG0673	inositol 2-dehydrogenase activity
ART_2869	COG2211	Major facilitator Superfamily
ART_2889	COG1174	glycine betaine transport
ART_2890	COG1174	glycine betaine transport
ART_2892	COG0346	lactoylglutathione lyase activity
ART_2894	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ART_2909	COG0789	Transcriptional regulator
ART_2915	COG0435	Glutathione S-transferase
ART_2921	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ART_2922	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ART_2923	COG1120	ATPase activity
ART_2925	COG2764	glyoxalase bleomycin resistance protein dioxygenase
ART_2927	COG1132	(ABC) transporter
ART_2931	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ART_2932	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ART_2933	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ART_2934	COG0776	regulation of translation
ART_2935	COG2372	response to copper ion
ART_2935	COG1276	copper resistance
ART_2938	COG0433	COG0433 Predicted ATPase
ART_2940	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ART_2949	COG0475	glutathione-regulated potassium exporter activity
ART_2951	COG0717	Belongs to the dCTP deaminase family
ART_2953	COG2111	Na H antiporter
ART_2953	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ART_2954	COG1006	Multisubunit Na H antiporter MnhC subunit
ART_2956	COG1863	multisubunit Na H antiporter MnhE subunit
ART_2957	COG2212	antiporter activity
ART_2958	COG1320	monovalent cation:proton antiporter activity
ART_2960	COG4721	ABC-type cobalt transport system, permease component
ART_2961	COG1122	ATPase activity
ART_2963	COG0039	L-malate dehydrogenase activity
ART_2964	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ART_2971	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ART_2972	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ART_2974	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ART_2976	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ART_2981	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ART_2983	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ART_2984	COG1280	lysine exporter protein (LysE YggA)
ART_2985	COG2132	Multicopper oxidase
ART_2987	COG0500	methyltransferase
ART_2988	COG0443	Heat shock 70 kDa protein
ART_2989	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ART_2990	COG0484	heat shock protein binding
ART_2991	COG0789	Transcriptional regulator
ART_2992	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ART_2996	COG1140	nitrate reductase beta subunit
ART_2999	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ART_3002	COG4585	Histidine kinase
ART_3003	COG2197	response regulator
ART_3012	COG2197	response regulator
ART_3013	COG4585	Histidine kinase
ART_3023	COG1476	TRANSCRIPTIONal
ART_3026	COG1063	alcohol dehydrogenase
ART_3027	COG0542	response to heat
ART_3030	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ART_3036	COG0151	Belongs to the GarS family
ART_3037	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ART_3040	COG2824	Alkylphosphonate utilization operon protein PhnA
ART_3042	COG1408	metallophosphoesterase
ART_3043	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ART_3048	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ART_3051	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ART_3054	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ART_3055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ART_3060	COG1228	amidohydrolase
ART_3069	COG1111	helicase
ART_3069	COG1205	dead DEAH box helicase
ART_3072	COG2890	protein-(glutamine-N5) methyltransferase activity
ART_3073	COG1285	pathogenesis
ART_3074	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ART_3074	COG1754	DNA topoisomerase type I activity
ART_3075	COG0248	Ppx GppA phosphatase
ART_3076	COG1082	Xylose isomerase domain protein TIM barrel
ART_3077	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ART_3078	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ART_3078	COG2169	Transcriptional regulator
ART_3081	COG0569	domain protein
ART_3082	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ART_3083	COG0123	including yeast histone deacetylase and acetoin utilization protein
ART_3085	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ART_3086	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
ART_3088	COG1175	transmembrane transport
ART_3096	COG1609	Transcriptional regulator
ART_3101	COG1028	Short-chain dehydrogenase reductase Sdr
ART_3101	COG3347	Dehydrogenase
ART_3102	COG1070	Carbohydrate kinase
ART_3103	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ART_3104	COG3458	cephalosporin-C deacetylase activity
ART_3105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ART_3107	COG0560	Phosphoserine phosphatase
ART_3109	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ART_3112	COG2353	YceI-like domain
ART_3113	COG0406	alpha-ribazole phosphatase activity
ART_3114	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ART_3115	COG0785	Cytochrome C biogenesis protein
ART_3117	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ART_3121	COG0488	(ABC) transporter
ART_3128	COG1132	(ABC) transporter
ART_3130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ART_3132	COG2205	protein histidine kinase activity
ART_3133	COG0745	RESPONSE REGULATOR receiver
ART_3136	COG3842	ATPase activity
ART_3137	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ART_3142	COG0673	inositol 2-dehydrogenase activity
ART_3143	COG0673	inositol 2-dehydrogenase activity
ART_3146	COG1609	Transcriptional regulator
ART_3149	COG1175	transmembrane transport
ART_3150	COG0395	ABC-type sugar transport system, permease component
ART_3151	COG0673	inositol 2-dehydrogenase activity
ART_3153	COG0823	Involved in the tonB-independent uptake of proteins
ART_3155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ART_3159	COG1476	TRANSCRIPTIONal
ART_3164	COG1028	Short-chain dehydrogenase reductase Sdr
ART_3169	COG4335	DNA alkylation repair
ART_3170	COG1846	Transcriptional regulator
ART_3183	COG3795	YCII-related domain
ART_3191	COG3971	2-oxopent-4-enoate hydratase activity
ART_3193	COG1012	belongs to the aldehyde dehydrogenase family
ART_3196	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ART_3200	COG0604	alcohol dehydrogenase
ART_3205	COG0343	queuine tRNA-ribosyltransferase activity
ART_3218	COG0626	cystathionine gamma-synthase activity
ART_3224	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ART_3237	COG0564	pseudouridine synthase activity
ART_3241	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ART_3243	COG1201	RNA secondary structure unwinding
ART_3248	COG2205	protein histidine kinase activity
ART_3249	COG0745	RESPONSE REGULATOR receiver
ART_3254	COG0590	tRNA wobble adenosine to inosine editing
ART_3255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ART_3258	COG1846	Transcriptional regulator
ART_3261	COG2062	phosphohistidine phosphatase, SixA
ART_3263	COG3547	Transposase (IS116 IS110 IS902 family)
ART_3264	COG2239	Acts as a magnesium transporter
ART_3265	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ART_3266	COG1940	carbohydrate kinase activity
ART_3268	COG4608	Belongs to the ABC transporter superfamily
ART_3269	COG0444	Belongs to the ABC transporter superfamily
ART_3270	COG0601	transmembrane transport
ART_3271	COG0747	negative chemotaxis
ART_3272	COG2186	Transcriptional regulator
ART_3275	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ART_3277	COG1959	2 iron, 2 sulfur cluster binding
ART_3280	COG0514	ATP-dependent DNA helicase (RecQ)
ART_3284	COG4948	Mandelate Racemase Muconate Lactonizing
ART_3292	COG1505	serine-type exopeptidase activity
ART_3298	COG3321	synthase
ART_3298	COG0604	alcohol dehydrogenase
ART_3298	COG1028	Short-chain dehydrogenase reductase Sdr
ART_3300	COG1966	Carbon starvation protein
ART_3306	COG3842	ATPase activity
ART_3309	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ART_3310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ART_3314	COG0588	phosphoglycerate mutase activity
ART_3315	COG0704	Plays a role in the regulation of phosphate uptake
ART_3316	COG5002	protein histidine kinase activity
ART_3317	COG0745	RESPONSE REGULATOR receiver
ART_3320	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ART_3321	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ART_3322	COG0215	cysteine-tRNA ligase activity
ART_3323	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ART_3328	COG0366	Alpha amylase catalytic
ART_3330	COG3281	Trehalose synthase
ART_3331	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ART_3337	COG3833	ABC-type maltose transport systems, permease component
ART_3338	COG0366	Alpha amylase catalytic
ART_3339	COG0277	FAD linked oxidase domain protein
ART_3341	COG3842	ATPase activity
ART_3342	COG0402	S-adenosylhomocysteine deaminase activity
ART_3343	COG1877	trehalose-phosphatase activity
ART_3360	COG2084	Dehydrogenase
ART_3362	COG1609	Transcriptional regulator
ART_3367	COG0395	ABC-type sugar transport system, permease component
ART_3368	COG3842	ATPase activity
ART_3376	COG1401	restriction endodeoxyribonuclease activity
ART_3378	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ART_3394	COG1028	Short-chain dehydrogenase reductase Sdr
ART_3397	COG1172	Belongs to the binding-protein-dependent transport system permease family
ART_3399	COG1072	(Pantothenic acid kinase))
ART_3400	COG1609	Transcriptional regulator
ART_3412	COG2801	Transposase and inactivated derivatives
ART_3431	COG1653	transport
ART_3432	COG1175	transmembrane transport
ART_3433	COG0395	ABC-type sugar transport system, permease component
ART_3434	COG1063	alcohol dehydrogenase
ART_3435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ART_3439	COG0456	acetyltransferase
ART_3441	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ART_3442	COG0165	Argininosuccinate lyase
ART_3443	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ART_3444	COG3842	ATPase activity
ART_3449	COG2610	gluconate transmembrane transporter activity
ART_3455	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ART_3456	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ART_3458	COG1053	succinate dehydrogenase
ART_3459	COG1028	Short-chain dehydrogenase reductase Sdr
ART_3462	COG1028	Short-chain dehydrogenase reductase Sdr
ART_3467	COG0179	Fumarylacetoacetate (FAA) hydrolase
ART_3468	COG0789	Transcriptional regulator
ART_3471	COG0561	phosphatase activity
ART_3476	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ART_3477	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ART_3481	COG1122	ATPase activity
ART_3482	COG1268	BioY protein
ART_3483	COG1960	acyl-CoA dehydrogenase activity
ART_3485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ART_3490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ART_3491	COG1028	Short-chain dehydrogenase reductase Sdr
ART_3492	COG1902	pentaerythritol trinitrate reductase activity
ART_3493	COG1309	transcriptional regulator
ART_3494	COG0477	Major facilitator Superfamily
ART_3495	COG0318	PFAM AMP-dependent synthetase and ligase
ART_3498	COG4770	biotin carboxylase activity
ART_3499	COG2301	Belongs to the HpcH HpaI aldolase family
ART_3501	COG0410	ABC transporter
ART_3502	COG0411	ABC transporter
ART_3505	COG1309	transcriptional regulator
ART_3509	COG0071	Belongs to the small heat shock protein (HSP20) family
ART_3511	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ART_3512	COG2197	response regulator
ART_3514	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ART_3526	COG1028	Short-chain dehydrogenase reductase Sdr
ART_3530	COG0783	Belongs to the Dps family
ART_3533	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ART_3534	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ART_3535	COG2080	2 iron, 2 sulfur cluster binding
ART_3538	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ART_3548	COG1793	dna ligase
ART_3548	COG3285	dna ligase
ART_3549	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ART_3552	COG0693	protein deglycase activity
ART_3560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ART_3561	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ART_3562	COG1120	ATPase activity
ART_3571	COG0477	Major facilitator Superfamily
ART_3572	COG1250	3-hydroxyacyl-CoA dehydrogenase
ART_3576	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ART_3577	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ART_3580	COG0477	Major facilitator Superfamily
ART_3581	COG0028	Belongs to the TPP enzyme family
ART_3583	COG2197	response regulator
ART_3584	COG4585	Histidine kinase
ART_3585	COG2409	Drug exporters of the RND superfamily
ART_3587	COG2801	Transposase and inactivated derivatives
ART_3589	COG3119	arylsulfatase activity
ART_3590	COG3119	arylsulfatase activity
ART_3592	COG4209	transmembrane transport
ART_3595	COG0395	ABC-type sugar transport system, permease component
ART_3601	COG0598	Magnesium transport protein CorA
ART_3605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ART_3606	COG4133	protoheme IX ABC transporter activity
ART_3613	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ART_3617	COG0444	Belongs to the ABC transporter superfamily
ART_3623	COG3142	Participates in the control of copper homeostasis
ART_3625	COG0702	epimerase
ART_3634	COG0415	Belongs to the DNA photolyase family
ART_3635	COG2409	Drug exporters of the RND superfamily
ART_3643	COG1780	Probably involved in ribonucleotide reductase function
ART_3644	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ART_3645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ART_3646	COG0431	NADPH-dependent FMN reductase
ART_3655	COG0561	phosphatase activity
ART_3667	COG2197	response regulator
ART_3671	COG2197	response regulator
ART_3673	COG1028	Short-chain dehydrogenase reductase Sdr
ART_3676	COG1012	belongs to the aldehyde dehydrogenase family
ART_3684	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ART_3689	COG0459	protein refolding
ART_3693	COG2205	protein histidine kinase activity
ART_3694	COG0745	RESPONSE REGULATOR receiver
ART_3695	COG3119	arylsulfatase activity
ART_3696	COG3119	arylsulfatase activity
ART_3700	COG1609	Transcriptional regulator
ART_3701	COG0673	inositol 2-dehydrogenase activity
ART_3702	COG5492	domain, Protein
ART_3705	COG3119	arylsulfatase activity
ART_3707	COG3119	arylsulfatase activity
ART_3717	COG0739	heme binding
ART_3718	COG1388	LysM domain
ART_3718	COG3103	Sh3 type 3 domain protein
ART_3718	COG0791	NLP P60 protein
ART_3724	COG0477	Major facilitator Superfamily
ART_3727	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ART_3729	COG1126	abc transporter atp-binding protein
ART_3730	COG0765	amino acid transport
ART_3731	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ART_3732	COG1132	(ABC) transporter
ART_3733	COG1309	transcriptional regulator
ART_3734	COG2814	Major facilitator Superfamily
ART_3735	COG1228	amidohydrolase
ART_3741	COG1742	UPF0060 membrane protein
ART_3743	COG2962	Rard protein
ART_3744	COG0483	inositol monophosphate 1-phosphatase activity
ART_3748	COG0045	succinate-CoA ligase (ADP-forming) activity
ART_3753	COG2814	Major facilitator Superfamily
ART_3754	COG0656	L-ascorbic acid biosynthetic process
ART_3755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ART_3759	COG0508	dehydrogenase complex catalyzes the overall conversion of
ART_3763	COG1396	sequence-specific DNA binding
ART_3769	COG0028	Belongs to the TPP enzyme family
ART_3770	COG0326	Molecular chaperone. Has ATPase activity
ART_3783	COG1090	epimerase
ART_3787	COG2186	Transcriptional regulator
ART_3789	COG1027	Aspartate ammonia-lyase
ART_3793	COG2186	Transcriptional regulator
ART_3795	COG2376	Dihydroxyacetone kinase
ART_3796	COG0698	ribose 5-phosphate isomerase
ART_3797	COG1250	3-hydroxyacyl-CoA dehydrogenase
ART_3798	COG1028	Short-chain dehydrogenase reductase Sdr
ART_3799	COG2271	Major facilitator Superfamily
ART_3800	COG0149	triose-phosphate isomerase activity
ART_3802	COG2610	gluconate transmembrane transporter activity
ART_3803	COG2084	Dehydrogenase
ART_3805	COG2186	Transcriptional regulator
ART_3809	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ART_3817	COG0747	negative chemotaxis
ART_3820	COG1070	Carbohydrate kinase
ART_3821	COG2115	Belongs to the xylose isomerase family
ART_3823	COG2017	converts alpha-aldose to the beta-anomer
ART_3824	COG0659	secondary active sulfate transmembrane transporter activity
ART_3837	COG3634	alkyl hydroperoxide reductase activity
ART_3843	COG1960	acyl-CoA dehydrogenase activity
ART_3846	COG2026	Addiction module toxin, RelE StbE family
ART_3847	COG2161	toxin-antitoxin pair type II binding
ART_3850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ART_3850	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ART_3852	COG1278	Cold shock
ART_3857	COG0477	Major facilitator Superfamily
ART_3860	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ART_3861	COG1472	Belongs to the glycosyl hydrolase 3 family
ART_3862	COG0138	bifunctional purine biosynthesis protein purh
ART_3864	COG2826	transposase and inactivated derivatives, IS30 family
ART_3866	COG2838	Isocitrate dehydrogenase
ART_3871	COG0411	ABC transporter
ART_3875	COG0395	ABC-type sugar transport system, permease component
ART_3876	COG1175	transmembrane transport
ART_3877	COG1653	transport
ART_3878	COG1940	carbohydrate kinase activity
ART_3880	COG0667	Aldo Keto reductase
ART_3882	COG2855	membrane
ART_3884	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ART_3885	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ART_3888	COG2197	response regulator
ART_3889	COG4585	Histidine kinase
ART_3893	COG0180	Tryptophanyl-tRNA synthetase
ART_3897	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ART_3900	COG2009	succinate dehydrogenase
ART_3902	COG0662	Cupin 2, conserved barrel domain protein
ART_3902	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ART_3903	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ART_3903	COG1473	amidohydrolase
ART_3911	COG0586	Pfam SNARE associated Golgi protein
ART_3912	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ART_3916	COG0148	phosphopyruvate hydratase activity
ART_3924	COG0861	Integral membrane protein TerC family
ART_3925	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ART_3927	COG1349	DNA-binding transcription factor activity
ART_3928	COG2017	converts alpha-aldose to the beta-anomer
ART_3930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ART_3931	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ART_3933	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ART_3935	COG1331	Highly conserved protein containing a thioredoxin domain
ART_3937	COG0577	efflux transmembrane transporter activity
ART_3937	COG1136	(ABC) transporter
ART_3941	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ART_3943	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ART_3946	COG4565	transcriptional regulatory protein
ART_3947	COG3290	protein histidine kinase activity
ART_3948	COG2851	Citrate transporter
ART_3953	COG0114	fumarate hydratase activity
ART_3954	COG0288	reversible hydration of carbon dioxide
ART_3956	COG1494	fructose-1,6-bisphosphatase
ART_3958	COG1482	cell wall glycoprotein biosynthetic process
ART_3970	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ART_3979	COG0489	protein tyrosine kinase activity
ART_3979	COG3206	protein involved in exopolysaccharide biosynthesis
ART_3981	COG0681	Belongs to the peptidase S26 family
ART_3988	COG0714	Associated with various cellular activities
ART_3989	COG0084	hydrolase, TatD family'
ART_3991	COG3583	domain protein
ART_3992	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ART_3994	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ART_3995	COG0488	(ABC) transporter
ART_4000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ART_4003	COG0193	aminoacyl-tRNA hydrolase activity
ART_4008	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ART_4009	COG0673	inositol 2-dehydrogenase activity
ART_4010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ART_4011	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ART_4014	COG2244	polysaccharide biosynthetic process
ART_4016	COG0438	transferase activity, transferring glycosyl groups
ART_4022	COG0579	oxidoreductase
ART_4043	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ART_4057	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ART_4060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ART_4060	COG1648	precorrin-2 dehydrogenase activity
ART_4063	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ART_4067	COG0733	neurotransmitter:sodium symporter activity
ART_4070	COG0477	Major facilitator Superfamily
ART_4071	COG4770	biotin carboxylase activity
ART_4074	COG0424	maF-like protein
ART_4085	COG2409	Drug exporters of the RND superfamily
ART_4090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ART_4097	COG2197	response regulator
ART_4100	COG0714	Associated with various cellular activities
ART_4102	COG1305	Transglutaminase-like
ART_4105	COG0631	protein serine/threonine phosphatase activity
ART_4109	COG1674	ftsk spoiiie
ART_4111	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ART_4116	COG4585	Histidine kinase
ART_4117	COG2197	response regulator
ART_4122	COG1175	transmembrane transport
ART_4124	COG1846	Transcriptional regulator
ART_4124	COG1940	carbohydrate kinase activity
ART_4125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ART_4130	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ART_4131	COG0154	amidase activity
ART_4132	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ART_4135	COG4209	transmembrane transport
ART_4136	COG0395	ABC-type sugar transport system, permease component
ART_4139	COG0673	inositol 2-dehydrogenase activity
ART_4141	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ART_4144	COG3579	cysteine-type endopeptidase activity
ART_4146	COG0494	nUDIX hydrolase
ART_4147	COG1051	belongs to the nudix hydrolase family
ART_4150	COG1131	(ABC) transporter
ART_4154	COG1063	alcohol dehydrogenase
ART_4155	COG0156	8-amino-7-oxononanoate synthase activity
ART_4158	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ART_4161	COG1228	amidohydrolase
ART_4168	COG0588	phosphoglycerate mutase activity
ART_4171	COG2183	response to ionizing radiation
ART_4172	COG2873	o-acetylhomoserine
ART_4173	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ART_4176	COG2755	lipolytic protein G-D-S-L family
ART_4180	COG1695	Transcriptional regulator
ART_4184	COG0423	glycine-tRNA ligase activity
ART_4192	COG3424	synthase
ART_4193	COG2239	Acts as a magnesium transporter
ART_4194	COG1309	transcriptional regulator
ART_4195	COG1511	domain protein
ART_4200	COG0358	DNA primase activity
ART_4201	COG2814	Major facilitator Superfamily
ART_4205	COG0297	glycogen (starch) synthase activity
ART_4206	COG1960	acyl-CoA dehydrogenase activity
ART_4208	COG0052	Belongs to the universal ribosomal protein uS2 family
ART_4209	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ART_4210	COG0528	UMP kinase activity
ART_4211	COG0233	cytoplasmic translational termination
ART_4215	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ART_4218	COG3275	phosphorelay sensor kinase activity
ART_4220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ART_4223	COG0022	dehydrogenase e1 component
ART_4224	COG0508	dehydrogenase complex catalyzes the overall conversion of
ART_4227	COG1309	transcriptional regulator
ART_4228	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ART_4230	COG1960	acyl-CoA dehydrogenase activity
ART_4239	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ART_4240	COG0750	zinc metalloprotease
ART_4244	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ART_4246	COG1902	pentaerythritol trinitrate reductase activity
ART_4246	COG0446	pyridine nucleotide-disulphide oxidoreductase
ART_4250	COG0442	prolyl-tRNA aminoacylation
ART_4256	COG0779	Required for maturation of 30S ribosomal subunits
ART_4259	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ART_4261	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ART_4262	COG1960	acyl-CoA dehydrogenase activity
ART_4264	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ART_4271	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ART_4272	COG1185	polyribonucleotide nucleotidyltransferase activity
ART_4273	COG0612	Peptidase, M16
ART_4281	COG0521	Mo-molybdopterin cofactor biosynthetic process
ART_4283	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ART_4286	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ART_4287	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ART_4288	COG1674	ftsk spoiiie
ART_4290	COG1546	Belongs to the CinA family
ART_4290	COG1058	Belongs to the CinA family
ART_4291	COG1396	sequence-specific DNA binding
ART_4292	COG1846	Transcriptional regulator
ART_4294	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ART_4295	COG2137	regulation of response to DNA damage stimulus
ART_4297	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ART_4298	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ART_4299	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ART_4300	COG2813	Specifically methylates the guanine in position
ART_4301	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ART_4304	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ART_4306	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ART_4307	COG0131	Imidazoleglycerol-phosphate dehydratase
ART_4308	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ART_4310	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ART_4314	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ART_4315	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ART_4316	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ART_4320	COG2814	Major facilitator Superfamily
ART_4324	COG0318	PFAM AMP-dependent synthetase and ligase
ART_4330	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ART_4331	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ART_4331	COG0072	phenylalanine-tRNA ligase activity
ART_4335	COG2186	Transcriptional regulator
ART_4343	COG1295	ribonuclease BN
ART_4345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ART_4346	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ART_4347	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ART_4348	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ART_4349	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ART_4350	COG1438	arginine binding
ART_4351	COG0006	proline dipeptidase activity
ART_4352	COG0137	argininosuccinate synthase activity
ART_4353	COG0165	Argininosuccinate lyase
ART_4359	COG1063	alcohol dehydrogenase
ART_4361	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ART_4363	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)