locus-tag class description MyAD_00020 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) MyAD_00030 ENOG4105DRP amino acid AbC transporter MyAD_00035 ENOG4105CDA abc transporter atp-binding protein MyAD_00040 ENOG4105CYC Transferase MyAD_00050 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) MyAD_00075 ENOG4105CPQ Dehydrogenase MyAD_00135 ENOG4108Z6B deaminase MyAD_00145 ENOG4105EVN Prephenate dehydrogenase MyAD_00155 ENOG4105E90 ABC transporter MyAD_00160 ENOG4105E90 ABC transporter MyAD_00175 ENOG41060H3 Protein of unknown function (DUF1049) MyAD_00190 ENOG4105EUZ Beta-lactamase domain protein MyAD_00200 ENOG4105BZU Histidine kinase MyAD_00220 ENOG4105CIH Imidazole acetol-phosphate transaminase MyAD_00285 ENOG4108VC7 Protein of unknown function (DUF2587) MyAD_00295 ENOG4108MKI Glycosyl transferase, family 2 MyAD_00315 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) MyAD_00320 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MyAD_00335 ENOG4105IQ5 FAD linked oxidase domain protein MyAD_00340 ENOG4108RG3 short-chain dehydrogenase reductase MyAD_00345 ENOG4108K7T Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases MyAD_00350 ENOG4105J1Z Arabinosyltransferase MyAD_00360 ENOG4105EEF Alkane 1-monooxygenase MyAD_00365 ENOG4108NUW Cell wall arabinan synthesis protein MyAD_00370 ENOG4105J1Z Arabinosyltransferase MyAD_00395 ENOG4105D8K carboxyl transferase MyAD_00405 ENOG4107RCI amp-dependent synthetase and ligase MyAD_00435 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids MyAD_00440 ENOG4106YN8 Prenyltransferase MyAD_00450 ENOG410602S Transferase MyAD_00470 ENOG410667J hydrolase MyAD_00475 ENOG4105PSQ Acyl-transferase MyAD_00480 ENOG4107B57 rieske 2fe-2S domain-containing protein MyAD_00500 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) MyAD_00520 ENOG4105CQC Prephenate dehydratase MyAD_00535 ENOG4108KGH TRANSCRIPTIONal MyAD_00540 ENOG4107YEV ferritin MyAD_00555 ENOG41085GJ domain protein MyAD_00605 ENOG4107TXC Transcriptional regulator MyAD_00610 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) MyAD_00615 ENOG4105CT3 Monooxygenase MyAD_00620 ENOG41060BG Tetr family transcriptional regulator MyAD_00625 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) MyAD_00630 ENOG4105DCG PHP domain protein MyAD_00645 ENOG4105CBC glutamate synthase MyAD_00655 ENOG4107RDT Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) MyAD_00660 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction MyAD_00680 ENOG4105CJP fad dependent oxidoreductase MyAD_00710 ENOG4107R50 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) MyAD_00740 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) MyAD_00745 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) MyAD_00770 ENOG4108RWI nicotinamidase MyAD_00775 ENOG4107TXC Transcriptional regulator MyAD_00780 ENOG4105CHH sulfate transporter MyAD_00810 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) MyAD_00815 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) MyAD_00840 ENOG4105E4E Thioester reductase domain-containing protein MyAD_00895 ENOG4105C26 Dehydrogenase MyAD_00900 ENOG4108JPW Aminotransferase MyAD_00910 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands MyAD_00925 ENOG4105E2Y ABC, transporter MyAD_00945 ENOG4107RA9 decarboxylase MyAD_00955 ENOG4105D2B acyl-CoA dehydrogenase MyAD_00960 ENOG4105D2B acyl-CoA dehydrogenase MyAD_00965 ENOG4105E3B Multicopper oxidase MyAD_00970 ENOG4105WH1 Two component transcriptional regulator luxr family MyAD_00975 ENOG4105BZU Histidine kinase MyAD_01005 ENOG4105CQ7 ATP-dependent helicase MyAD_01025 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b MyAD_01030 ENOG4107RR1 TRANSCRIPTIONal MyAD_01035 ENOG4105CHR reductase MyAD_01070 ENOG4108IG5 Transcriptional regulator MyAD_01080 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) MyAD_01130 ENOG4108R85 Short chain dehydrogenase MyAD_01160 ENOG4105C7R Atpase associated with various cellular activities aaa_3 MyAD_01190 ENOG4105WH1 Two component transcriptional regulator luxr family MyAD_01195 ENOG4108TKH Nitroreductase MyAD_01225 ENOG4105ECR NmrA family MyAD_01235 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) MyAD_01245 ENOG4105EMN RNA polymerase sigma factor MyAD_01255 ENOG4105C5H ABC transporter MyAD_01265 ENOG410900P UPF0336 protein MyAD_01270 ENOG4105C7B Threonine dehydratase MyAD_01290 ENOG4105C0R drug resistance transporter emrb qaca subfamily MyAD_01320 ENOG4107S1E Beta-lactamase MyAD_01330 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) MyAD_01340 ENOG4105KIR Thiol-disulfide oxidoreductase dcc MyAD_01380 ENOG4107WA4 MmpL domain-containing protein MyAD_01400 ENOG4105C9K Endothelin-converting enzyme 1 MyAD_01405 ENOG4105S7A ErfK ybiS ycfS ynhG family protein MyAD_01420 ENOG4105VPX protein, conserved in bacteria MyAD_01430 ENOG4105C01 Dihydroxy-acid dehydratase MyAD_01445 ENOG4107ZBN O-methyltransferase MyAD_01465 ENOG4105E5G Alpha beta hydrolase fold MyAD_01490 ENOG4105CBG Sulfatase MyAD_01540 ENOG4105E1F short-chain dehydrogenase reductase MyAD_01545 ENOG4105XPP Protein of unknown function (DUF1275) MyAD_01605 ENOG4105CY3 ABC transporter, permease MyAD_01615 ENOG4108WYP Transcriptional regulator MyAD_01635 ENOG4105DZQ phospholipase D Transphosphatidylase MyAD_01640 ENOG4105JN3 extra-cytoplasmic solute receptor family protein MyAD_01645 ENOG4105CSU acyl-Coa dehydrogenase MyAD_01660 ENOG4105CHR reductase MyAD_01665 ENOG4108RZE Tetr family transcriptional regulator MyAD_01675 ENOG4106FTQ Taurine ABC transporter, periplasmic MyAD_01680 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component MyAD_01695 ENOG4105D7N magnesium and cobalt transport protein CorA MyAD_01700 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) MyAD_01705 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) MyAD_01715 ENOG4105C1G acyl-Coa dehydrogenase MyAD_01725 ENOG4107RSM transcriptional regulator MyAD_01735 ENOG4105C1G acyl-Coa dehydrogenase MyAD_01760 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr MyAD_01765 ENOG4105C26 Dehydrogenase MyAD_01770 ENOG4108UGJ Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) MyAD_01775 ENOG4105XEA Tetr family transcriptional regulator MyAD_01780 ENOG4105EUB pirin domain protein MyAD_01785 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) MyAD_01790 ENOG4105E98 transcriptional regulator DeoR family MyAD_01795 ENOG4105DE4 1-phosphofructokinase MyAD_01800 ENOG4105DM4 PTS System MyAD_01805 ENOG4105KRI phosphocarrier protein (HPr MyAD_01810 ENOG4108PZM peptidase S8 and S53, subtilisin, kexin, sedolisin MyAD_01875 ENOG4106F1P AAA ATPase, central domain protein MyAD_01905 ENOG4105EUB pirin domain protein MyAD_01925 ENOG4105CKW Inner membrane protein yedI MyAD_01940 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) MyAD_01995 ENOG4105TV9 FHA Domain-Containing protein MyAD_02000 ENOG4105HZM Fha domain containing protein MyAD_02015 ENOG4105CJN penicillin-binding protein MyAD_02025 ENOG4105D9P serine threonine protein kinase MyAD_02030 ENOG4105EBR Carboxylesterase MyAD_02045 ENOG4105XBB septation inhibitor protein MyAD_02065 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) MyAD_02090 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) MyAD_02095 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) MyAD_02100 ENOG4105K7N UPF0232 protein MyAD_02105 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) MyAD_02110 ENOG4108J5G 6-phosphogluconate dehydrogenase MyAD_02115 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) MyAD_02120 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) MyAD_02125 ENOG4108CDF RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) MyAD_02130 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins MyAD_02140 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) MyAD_02145 ENOG4107QJE Chromosome Partitioning Protein MyAD_02160 ENOG4108E1C hydrolase MyAD_02165 ENOG4105K63 Thioredoxin MyAD_02170 ENOG4105C3M thioredoxin reductase MyAD_02220 ENOG4108M0D major facilitator superfamily MyAD_02225 ENOG41081DT UPF0301 protein MyAD_02235 ENOG41064CH Probable lipoprotein LpqN MyAD_02240 ENOG4105C8T Leucyl-tRNA synthetase MyAD_02245 ENOG4105E2A Dehydrogenase MyAD_02250 ENOG4108IXY short-chain dehydrogenase reductase MyAD_02265 ENOG4105CDA abc transporter atp-binding protein MyAD_02270 ENOG4105EAD ABC transporter MyAD_02275 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone MyAD_02290 ENOG4105CZA synthase MyAD_02315 ENOG4105BZ4 penicillin-binding protein MyAD_02325 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) MyAD_02330 ENOG4107YH6 single-stranded DNA-binding protein MyAD_02335 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) MyAD_02340 ENOG4105K9Q Binds to the 23S rRNA (By similarity) MyAD_02375 ENOG4105DKK Benzoate MyAD_02380 ENOG4108JCI Transcriptional regulator MyAD_02400 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_02405 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase MyAD_02415 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) MyAD_02455 ENOG4105CMG Carbohydrate kinase MyAD_02460 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase MyAD_02475 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component MyAD_02495 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) MyAD_02545 ENOG4105ECQ AraC Family Transcriptional Regulator MyAD_02600 ENOG4105F95 Monooxygenase MyAD_02620 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator MyAD_02625 ENOG4105CNN ABC, transporter MyAD_02630 ENOG4105C2J ABC transporter MyAD_02640 ENOG4107Z1W Fructose transport system kinase MyAD_02645 ENOG4105ETE Transcriptional regulator (LacI family MyAD_02660 ENOG4108JT6 LycopEne MyAD_02670 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase MyAD_02675 ENOG4105CI0 Citrate lyase MyAD_02680 ENOG4108WKN secreted protein MyAD_02685 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) MyAD_02720 ENOG4107R13 MMPL domain protein MyAD_02730 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) MyAD_02745 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) MyAD_02755 ENOG4105CGD Nad-dependent epimerase dehydratase MyAD_02760 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_02765 ENOG4105EMU Dehydrogenase MyAD_02775 ENOG41082SX arsR family transcriptional regulator MyAD_02790 ENOG4105D2B acyl-CoA dehydrogenase MyAD_02815 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_02825 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase MyAD_02835 ENOG4105X7H acyl-CoA dehydrogenase MyAD_02850 ENOG4105CSU acyl-Coa dehydrogenase MyAD_02875 ENOG41090MF Protein of unknown function (DUF3068) MyAD_02930 ENOG41073B4 coagulation factor 5 8 type domain-containing protein MyAD_02935 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) MyAD_02950 ENOG4105CHR reductase MyAD_02955 ENOG4105CHU acetyl-coa acetyltransferase MyAD_02965 ENOG4105DYW oxidoreductase MyAD_02970 ENOG4105WBV Transcriptional regulator MyAD_02975 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) MyAD_02980 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) MyAD_02985 ENOG4105CSU acyl-Coa dehydrogenase MyAD_03020 ENOG4107RCI amp-dependent synthetase and ligase MyAD_03025 ENOG4105MXW flavin reductase domain protein, FMN-binding MyAD_03035 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) MyAD_03060 ENOG4107QZF nitrite reductase NADPH large subunit MyAD_03085 ENOG4107R7A Allophanate hydrolase subunit 2 MyAD_03090 ENOG4105P4J Allophanate hydrolase, subunit 1 MyAD_03110 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase MyAD_03115 ENOG4105DWY Agmatine deiminase MyAD_03120 ENOG4108ZHJ Organic hydroperoxide resistance protein MyAD_03125 ENOG4105K56 Transcriptional regulator MyAD_03130 ENOG4107SCK Monooxygenase MyAD_03135 ENOG4105E2A Dehydrogenase MyAD_03145 ENOG4108SGK Tetr family transcriptional regulator MyAD_03245 ENOG4105C8Y Acetylornithine aminotransferase MyAD_03250 ENOG4108EKI Dehydrogenase MyAD_03270 ENOG4105KNY Microcompartments protein MyAD_03300 ENOG4105KAV tspo and mbr like protein MyAD_03310 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) MyAD_03325 ENOG4105CJP fad dependent oxidoreductase MyAD_03330 ENOG4105C26 Dehydrogenase MyAD_03350 ENOG4105C0R drug resistance transporter emrb qaca subfamily MyAD_03365 ENOG4105DSE periplasmic solute binding protein MyAD_03385 ENOG4107R6F Alpha Beta Hydrolase Fold protein MyAD_03395 ENOG4105E6M Sulphatase-modifying factor protein MyAD_03450 ENOG4105CHR reductase MyAD_03455 ENOG4105CMT Dihydroxyacetone kinase MyAD_03460 ENOG4107YVI ribose 5-phosphate isomerase MyAD_03470 ENOG4105DWF phosphomethylpyrimidine kinase MyAD_03475 ENOG4107R7Y intracellular protease Pfpi family MyAD_03480 ENOG4105CHR reductase MyAD_03500 ENOG4105IW1 AmiS UreI transporter MyAD_03505 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) MyAD_03510 ENOG4106H31 ATP-dependent protease ATP-binding subunit-like protein MyAD_03560 ENOG4105C2J ABC transporter MyAD_03565 ENOG4105CNN ABC, transporter MyAD_03570 ENOG410905P Pyridoxamine 5-phosphate MyAD_03600 ENOG4105H3G oxidoreductase MyAD_03630 ENOG4105J7D transcriptional regulator MyAD_03650 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_03655 ENOG4105EWI Short-chain dehydrogenase reductase Sdr MyAD_03660 ENOG4105D2B acyl-CoA dehydrogenase MyAD_03680 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase MyAD_03695 ENOG4106F1P AAA ATPase, central domain protein MyAD_03700 ENOG4108T50 Protein of unknown function (DUF690) MyAD_03725 ENOG4106V5Y EsaT-6 like protein MyAD_03730 ENOG4106BSN growth MyAD_03735 ENOG4106K94 growth MyAD_03740 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin MyAD_03745 ENOG4106VYT conserved transmembrane protein MyAD_03760 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) MyAD_03780 ENOG4105CBG Sulfatase MyAD_03800 ENOG410841Q phosphoesterase PA-phosphatase related protein MyAD_03825 ENOG4105CFF transcriptional regulator MyAD_03840 ENOG4105BZN citrate synthase MyAD_03845 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) MyAD_03910 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) MyAD_03930 ENOG4105EW9 transcriptional regulator AsnC family MyAD_03960 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase MyAD_03965 ENOG4105BZP glycoside hydrolase 15-related MyAD_03980 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) MyAD_03995 ENOG4105DEF Extracellular solute-binding protein, family 5 MyAD_04000 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MyAD_04015 ENOG4108JQ7 (ABC) transporter MyAD_04190 ENOG4105DHP deoxycytidine triphosphate deaminase MyAD_04245 ENOG4105DF6 Fe-S oxidoreductase MyAD_04305 ENOG4106MP8 UPF0754 membrane protein MyAD_04320 ENOG4105CFG Acts as a chaperone (By similarity) MyAD_04325 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ MyAD_04330 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) MyAD_04335 ENOG4105KNI merR family transcriptional Regulator MyAD_04415 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit MyAD_04445 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) MyAD_04450 ENOG4105C57 major facilitator superfamily MyAD_04460 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN MyAD_04490 ENOG4107XZ0 Peptidase M50 MyAD_04500 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis MyAD_04535 ENOG4105F2Z 3-oxoadipate enol-lactonase MyAD_04540 ENOG4105EYF MMPL domain protein MyAD_04550 ENOG4105EEQ Na H antiporter MyAD_04595 ENOG4105CM2 brancheD-chain amino acid aminotransferase MyAD_04600 ENOG4105EMU Dehydrogenase MyAD_04610 ENOG4105DEN Luciferase family MyAD_04630 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone MyAD_04635 ENOG4105FDP GntR family transcriptional regulator MyAD_04640 ENOG4105CHR reductase MyAD_04655 ENOG4108JPW Aminotransferase MyAD_04665 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) MyAD_04670 ENOG4107Q25 Serine Threonine protein kinase MyAD_04675 ENOG4105CT1 (ABC) transporter MyAD_04690 ENOG4107RZ7 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) MyAD_04695 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) MyAD_04705 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) MyAD_04720 ENOG4105IIU Aminopeptidase MyAD_04725 ENOG4105IIU Aminopeptidase MyAD_04730 ENOG4107R13 MMPL domain protein MyAD_04750 ENOG4105C2W permease MyAD_04755 ENOG4105C26 Dehydrogenase MyAD_04780 ENOG4105F95 Monooxygenase MyAD_04795 ENOG4105DWF phosphomethylpyrimidine kinase MyAD_04800 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) MyAD_04805 ENOG4105C0R drug resistance transporter emrb qaca subfamily MyAD_04810 ENOG410630P Transcriptional regulator MyAD_04850 ENOG4107EXU Short-chain dehydrogenase reductase Sdr MyAD_04870 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) MyAD_04890 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit MyAD_04905 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) MyAD_04920 ENOG4105H08 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) MyAD_04925 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) MyAD_04940 ENOG4105KJM monovalent cation h antiporter subunit g MyAD_04945 ENOG410684G monovalent cation H antiporter subunit F MyAD_04955 ENOG4108JPZ Monovalent cation H antiporter subunit D MyAD_04960 ENOG4105MKQ Monovalent cation H antiporter subunit C MyAD_04965 ENOG4105D65 subunit l MyAD_04980 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme MyAD_04995 ENOG4105E39 Enoyl-CoA hydratase MyAD_05000 ENOG4105C1G acyl-Coa dehydrogenase MyAD_05005 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_05040 ENOG4105D4U had-superfamily hydrolase, subfamily iia MyAD_05055 ENOG4105EMU Dehydrogenase MyAD_05065 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component MyAD_05070 ENOG4105E2Y ABC, transporter MyAD_05075 ENOG4105GVF (ABC) transporter MyAD_05080 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) MyAD_05115 ENOG4105CSR polyphosphate kinase 2 MyAD_05150 ENOG4108NUI synthase MyAD_05155 ENOG4108NUI synthase MyAD_05170 ENOG4106TD9 Diguanylate cyclase MyAD_05200 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase MyAD_05205 ENOG4105CSR polyphosphate kinase 2 MyAD_05215 ENOG4106BRA Membrane MyAD_05225 ENOG4105V9F hemagglutinin MyAD_05280 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) MyAD_05290 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) MyAD_05295 ENOG4105BZU Histidine kinase MyAD_05300 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MyAD_05315 ENOG41063NU Membrane MyAD_05360 ENOG4108RXW HAD-superfamily subfamily IB hydrolase MyAD_05370 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) MyAD_05375 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) MyAD_05440 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase MyAD_05445 ENOG4108RH7 phosphoglycerate mutase MyAD_05455 ENOG4107QIV Cytochrome c biogenesis protein MyAD_05465 ENOG4105CRE cytochrome C MyAD_05505 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) MyAD_05510 ENOG4105CMR udp-glucose 4-epimerase MyAD_05565 ENOG4108UMN azlc family MyAD_05635 ENOG4108IG5 Transcriptional regulator MyAD_05650 ENOG4105E5D amino acid MyAD_05655 ENOG4108RKS Short-chain dehydrogenase reductase Sdr MyAD_05660 ENOG4105CHR reductase MyAD_05680 ENOG4105PDP Short chain dehydrogenase MyAD_05690 ENOG4107SIQ Naphthoate synthase MyAD_05725 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_05735 ENOG4105CI2 imidazolone-5-propionate hydrolase MyAD_05740 ENOG4107TCW O-succinylbenzoate synthase MyAD_05765 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) MyAD_05825 ENOG4106CKT MyAD_05835 ENOG4105GSW MyAD_05870 ENOG4105EMU Dehydrogenase MyAD_05875 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) MyAD_05880 ENOG4105CKI cobalamin synthesis protein MyAD_05900 ENOG4108S8N class II Aldolase MyAD_05905 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) MyAD_05910 ENOG4105NBK UPF0345 protein MyAD_05915 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) MyAD_05920 ENOG4105P52 geranylgeranyl reductase MyAD_05930 ENOG4105D0M Protease HtpX homolog MyAD_05950 ENOG4108VPT UPF0234 protein MyAD_05980 ENOG4105BZU Histidine kinase MyAD_06030 ENOG4107RJ7 Glycosyl transferase (Group 1 MyAD_06045 ENOG4105C7H Helicase, RecD TraA family MyAD_06050 ENOG4107QKA exodeoxyribonuclease V beta MyAD_06055 ENOG4105DSY exodeoxyribonuclease V, gamma MyAD_06095 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) MyAD_06100 ENOG41081JD Transcriptional regulator MyAD_06125 ENOG4105WDJ 50S ribosomal protein L33 MyAD_06135 ENOG4108F01 MaoC domain protein MyAD_06160 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) MyAD_06165 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) MyAD_06175 ENOG4105C1B dTDP-glucose 4-6-dehydratase MyAD_06220 ENOG4108QV3 biosynthesis protein MyAD_06245 ENOG4108NUI synthase MyAD_06305 ENOG4108VZM 50s ribosomal protein L10 MyAD_06310 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) MyAD_06320 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) MyAD_06325 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) MyAD_06350 ENOG4105CSU acyl-Coa dehydrogenase MyAD_06395 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) MyAD_06400 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) MyAD_06405 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) MyAD_06430 ENOG4105C8Y Acetylornithine aminotransferase MyAD_06435 ENOG4105CIK Amidinotransferase MyAD_06440 ENOG4105F7P transcriptional regulator AsnC family MyAD_06465 ENOG4105XDV MyAD_06490 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) MyAD_06495 ENOG4105C57 major facilitator superfamily MyAD_06510 ENOG4105EBR Carboxylesterase MyAD_06525 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) MyAD_06530 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) MyAD_06535 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) MyAD_06540 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity MyAD_06545 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) MyAD_06550 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) MyAD_06555 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) MyAD_06560 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) MyAD_06570 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal MyAD_06595 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) MyAD_06610 ENOG4105XPP Protein of unknown function (DUF1275) MyAD_06650 ENOG4105C26 Dehydrogenase MyAD_06660 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) MyAD_06675 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) MyAD_06680 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) MyAD_06685 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) MyAD_06690 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits MyAD_06695 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) MyAD_06700 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) MyAD_06705 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) MyAD_06710 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) MyAD_06715 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) MyAD_06720 ENOG410849U 50S ribosomal protein L30 MyAD_06725 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) MyAD_06735 ENOG4108WQH regulatoR MyAD_06745 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) MyAD_06760 ENOG4105WN5 stage II sporulation protein MyAD_06765 ENOG4105CSH Transporter MyAD_06770 ENOG4106N8J Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) MyAD_06805 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) MyAD_06820 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) MyAD_06835 ENOG4105WH1 Two component transcriptional regulator luxr family MyAD_06855 ENOG4105C26 Dehydrogenase MyAD_06860 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase MyAD_06865 ENOG4105C1B dTDP-glucose 4-6-dehydratase MyAD_06880 ENOG4105CUX Signal transduction histidine kinase MyAD_06885 ENOG4105C3M thioredoxin reductase MyAD_06915 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits MyAD_06920 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) MyAD_06925 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) MyAD_06930 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) MyAD_06935 ENOG4108ZT0 50S ribosomal protein l17 MyAD_06965 ENOG4107AQZ Membrane MyAD_06975 ENOG4105EG6 Saccharopine dehydrogenase MyAD_07005 ENOG4105EAH synthase MyAD_07015 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin MyAD_07045 ENOG4107RR1 TRANSCRIPTIONal MyAD_07050 ENOG4105C26 Dehydrogenase MyAD_07055 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) MyAD_07065 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) MyAD_07095 ENOG4108ZFT Dehydratase small subunit MyAD_07105 ENOG4105YCI dehydratase medium subunit MyAD_07110 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit MyAD_07125 ENOG4105CUB amino acid MyAD_07130 ENOG4105CPD ethanolamine ammonia-lyase MyAD_07135 ENOG4107FQ9 ethanolamine ammonia-lyase MyAD_07145 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) MyAD_07150 ENOG4108UJD 30S ribosomal protein S9 MyAD_07160 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) MyAD_07175 ENOG4105C1J atp-dependent rna helicase MyAD_07180 ENOG4105DYW oxidoreductase MyAD_07190 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) MyAD_07215 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) MyAD_07230 ENOG4105E98 transcriptional regulator DeoR family MyAD_07235 ENOG4105CTS PTS system mannitol-specific MyAD_07240 ENOG4105CPQ Dehydrogenase MyAD_07255 ENOG4105CVK Glutamate decarboxylase MyAD_07260 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) MyAD_07280 ENOG41080E2 ribosomal-protein-alanine acetyltransferase MyAD_07285 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) MyAD_07300 ENOG4105C85 amino acid MyAD_07310 ENOG4108ZFT Dehydratase small subunit MyAD_07315 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit MyAD_07320 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) MyAD_07325 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) MyAD_07345 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) MyAD_07365 ENOG4108VT4 MyAD_07375 ENOG4107QVP Dehydrogenase MyAD_07385 ENOG4105CH6 catalase MyAD_07400 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) MyAD_07405 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) MyAD_07455 ENOG4105PDP Short chain dehydrogenase MyAD_07460 ENOG410829K Lysine exporter protein (Lyse ygga) MyAD_07475 ENOG4107TXC Transcriptional regulator MyAD_07485 ENOG4105EHG Permease protein MyAD_07490 ENOG4105E0A ABC, transporter MyAD_07510 ENOG4107VGR Catalase MyAD_07525 ENOG4108J2R molybdopterin oxidoreductase MyAD_07530 ENOG4105EQH reductase MyAD_07535 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) MyAD_07540 ENOG4105CSU acyl-Coa dehydrogenase MyAD_07560 ENOG4105ERH Fumarylacetoacetate hydrolase MyAD_07570 ENOG4108VCT Sulfite exporter TauE/SafE MyAD_07585 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) MyAD_07595 ENOG4105XTG Pfam:DUF156 MyAD_07645 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) MyAD_07660 ENOG4105GWZ Roadblock lc7 family protein MyAD_07675 ENOG4107Z6C Pentapeptide repeat-containing protein MyAD_07680 ENOG4105IDI abc transporter atp-binding protein MyAD_07685 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase MyAD_07710 ENOG4108IQK o-acetylhomoserine MyAD_07715 ENOG4105E9K Isocitrate dehydrogenase MyAD_07725 ENOG4105CGK Exodeoxyribonuclease III MyAD_07740 ENOG4107H3J ribonuclease MyAD_07745 ENOG4105KPY Small multidrug resistance protein MyAD_07750 ENOG4105EA8 2-Nitropropane dioxygenase MyAD_07755 ENOG4105DZ1 carboxypeptidase MyAD_07760 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) MyAD_07785 ENOG4108KPJ rna polymerase sigma factor MyAD_07805 ENOG4105E33 succinate dehydrogenase MyAD_07835 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) MyAD_07860 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain MyAD_07870 ENOG4108KK1 membrane protein AbrB duplication MyAD_07895 ENOG4107RM1 amidohydrolase MyAD_07915 ENOG4108W1A pseudouridine synthase MyAD_07925 ENOG4105CHR reductase MyAD_07935 ENOG4105EJ2 Transcriptional regulator MyAD_07955 ENOG4107QRT dEAD DEAH box helicase MyAD_07975 ENOG41061TZ Short-chain dehydrogenase reductase Sdr MyAD_07990 ENOG4105C26 Dehydrogenase MyAD_08020 ENOG4105NPE arsR family transcriptional regulator MyAD_08045 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone MyAD_08085 ENOG4108JIK carboxylase MyAD_08110 ENOG4107WR6 Maf-like protein MyAD_08120 ENOG4105D8K carboxyl transferase MyAD_08125 ENOG4105J5T Amp-dependent synthetase and ligase MyAD_08135 ENOG4107STW synthase MyAD_08195 ENOG4105D3Q Sugar transferase MyAD_08245 ENOG4107TB5 TRANSCRIPTIONal MyAD_08275 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) MyAD_08285 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) MyAD_08300 ENOG4107QKV phosphomannomutase MyAD_08310 ENOG4105EIP mannose-6-phosphate isomerase MyAD_08315 ENOG4105EEF Alkane 1-monooxygenase MyAD_08320 ENOG41084UD rubredoxin MyAD_08325 ENOG4105VCQ rubredoxin MyAD_08360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MyAD_08365 ENOG4105BZU Histidine kinase MyAD_08380 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea MyAD_08400 ENOG4105C94 Transporter MyAD_08420 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) MyAD_08425 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase MyAD_08430 ENOG4108RAV Conserved protein MyAD_08440 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) MyAD_08450 ENOG4108Z66 YbaK ebsC protein MyAD_08455 ENOG4105EMN RNA polymerase sigma factor MyAD_08460 ENOG4105WMN AntiSigma factor MyAD_08480 ENOG4107TE5 Lipid kinase MyAD_08490 ENOG4105K5B UPF0225 protein MyAD_08495 ENOG4106NZI LysR family Transcriptional regulator MyAD_08505 ENOG4105CC9 acyl-Coa dehydrogenase MyAD_08510 ENOG4105D2B acyl-CoA dehydrogenase MyAD_08515 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) MyAD_08535 ENOG4108ZM9 phosphoglycerate mutase MyAD_08550 ENOG4105C1J atp-dependent rna helicase MyAD_08595 ENOG4105C9M aspartyl-trna synthetase MyAD_08600 ENOG4108YIQ Alpha beta hydrolase MyAD_08620 ENOG4107SVH Potassium channel protein MyAD_08630 ENOG4105CHU acetyl-coa acetyltransferase MyAD_08645 ENOG4108K8U Glycerol operon regulatory protein MyAD_08660 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) MyAD_08670 ENOG4107SZ9 Hydantoinase oxoprolinase MyAD_08690 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) MyAD_08710 ENOG41063PX domain protein MyAD_08715 ENOG4105DJZ UPF0182 protein MyAD_08750 ENOG4105VTR Integrase MyAD_08835 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation MyAD_08840 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) MyAD_08845 ENOG4107TB5 TRANSCRIPTIONal MyAD_08850 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) MyAD_08885 ENOG4107T8P acyl-Coa dehydrogenase MyAD_08890 ENOG4107RSM transcriptional regulator MyAD_08905 ENOG4105KDM Diguanylate cyclase with gaf sensor MyAD_08915 ENOG4105C0A alcohol dehydrogenase MyAD_08920 ENOG4105C26 Dehydrogenase MyAD_08960 ENOG4107RN3 metallophosphoesterase MyAD_08980 ENOG4105DGU Histone deacetylase MyAD_09040 ENOG4107H3J ribonuclease MyAD_09050 ENOG4105EMU Dehydrogenase MyAD_09055 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) MyAD_09060 ENOG4107RN3 metallophosphoesterase MyAD_09070 ENOG4105CYX Short-chain dehydrogenase reductase Sdr MyAD_09090 ENOG4105DFH Transport of potassium into the cell (By similarity) MyAD_09120 ENOG4108RZE Tetr family transcriptional regulator MyAD_09245 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MyAD_09260 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MyAD_09265 ENOG4105DF2 NADH dehydrogenase subunit j MyAD_09270 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MyAD_09275 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) MyAD_09280 ENOG4108IEH NADH dehydrogenase subunit g MyAD_09295 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MyAD_09300 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain MyAD_09305 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MyAD_09355 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase MyAD_09360 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F MyAD_09380 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) MyAD_09385 ENOG4108KC1 acyl-Coa dehydrogenase MyAD_09405 ENOG4105C1G acyl-Coa dehydrogenase MyAD_09415 ENOG4107TK4 histidinol-phosphate phosphatase MyAD_09435 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) MyAD_09440 ENOG4105D8X mechanosensitive ion channel MyAD_09450 ENOG4105CAK Cell division ATP-binding protein ftsE MyAD_09455 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) MyAD_09460 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) MyAD_09465 ENOG4105BZU Histidine kinase MyAD_09480 ENOG4105DQE DNA ligase MyAD_09495 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr MyAD_09525 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) MyAD_09555 ENOG4105NI8 Cytosine-specific methyltransferase MyAD_09565 ENOG4105C4R Atp-dependent dna helicase MyAD_09585 ENOG4105C0D helicase MyAD_09600 ENOG4107QRT dEAD DEAH box helicase MyAD_09640 ENOG4108UVJ appr-1-p processing domain protein MyAD_09645 ENOG4105D8X mechanosensitive ion channel MyAD_09650 ENOG41086VY Fic/DOC family MyAD_09660 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) MyAD_09695 ENOG4105WWF Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) MyAD_09700 ENOG4105CI1 PTS System MyAD_09705 ENOG4105C5Y PTS System MyAD_09710 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) MyAD_09715 ENOG4105CE4 GlcNAc 6-P deacetylase MyAD_09750 ENOG41083TI Protein CrcB homolog MyAD_09755 ENOG41083YR Protein CrcB homolog MyAD_09775 ENOG4108ISG Major Facilitator MyAD_09790 ENOG4105KBX Transcriptional regulator, TetR family MyAD_09825 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) MyAD_09835 ENOG4105BZ1 (ABC) transporter MyAD_09840 ENOG4105BZ1 (ABC) transporter MyAD_09850 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_09865 ENOG4105C1G acyl-Coa dehydrogenase MyAD_09870 ENOG4105CC9 acyl-Coa dehydrogenase MyAD_09900 ENOG4105C1G acyl-Coa dehydrogenase MyAD_09910 ENOG4105CHU acetyl-coa acetyltransferase MyAD_09915 ENOG4105C1G acyl-Coa dehydrogenase MyAD_09920 ENOG4108WYP Transcriptional regulator MyAD_09930 ENOG4105D22 carbon starvation protein MyAD_09935 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) MyAD_09985 ENOG4105CBC glutamate synthase MyAD_09990 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) MyAD_10015 ENOG4108YYH Nadph-dependent fmn reductase MyAD_10025 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) MyAD_10030 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) MyAD_10095 ENOG4105EJ2 Transcriptional regulator MyAD_10100 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) MyAD_10120 ENOG4105WH1 Two component transcriptional regulator luxr family MyAD_10130 ENOG4105C7W Xanthine dehydrogenase MyAD_10135 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit MyAD_10140 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding MyAD_10160 ENOG4105DQ4 alcohol dehydrogenase MyAD_10180 ENOG4105EAC phosphoserine phosphatase MyAD_10185 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MyAD_10195 ENOG4108VW9 Membrane MyAD_10200 ENOG4105DKW ABC transporter MyAD_10230 ENOG4108V0V Pyrrolo-quinoline quinone MyAD_10235 ENOG4105EVB acetyltransferase MyAD_10255 ENOG4108KQJ Type 11 methyltransferase MyAD_10265 ENOG4105C10 Electron transfer flavoprotein MyAD_10285 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) MyAD_10295 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_10300 ENOG4105CPT Alpha beta hydrolase MyAD_10320 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) MyAD_10330 ENOG4105P3N Membrane MyAD_10355 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) MyAD_10360 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) MyAD_10365 ENOG4105C7K acetolactate synthase MyAD_10375 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) MyAD_10400 ENOG4108ZP8 Acetolactate synthase small subunit MyAD_10405 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase MyAD_10430 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) MyAD_10440 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) MyAD_10445 ENOG4105D3R alkyl hydroperoxide reductase MyAD_10450 ENOG4105E5T Major Facilitator Superfamily MyAD_10455 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase MyAD_10460 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) MyAD_10490 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) MyAD_10510 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) MyAD_10515 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) MyAD_10525 ENOG4105C28 cystathionine MyAD_10530 ENOG4105CPF Cell wall formation (By similarity) MyAD_10550 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) MyAD_10555 ENOG4105DP4 dak2 domain fusion protein ylov MyAD_10580 ENOG4105WN5 stage II sporulation protein MyAD_10585 ENOG4107QZ7 Cellulose synthase catalytic subunit MyAD_10590 ENOG4107SGM protein serine threonine phosphatase MyAD_10645 ENOG4105CV8 reductase MyAD_10650 ENOG4105CV8 reductase MyAD_10670 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) MyAD_10675 ENOG4106H78 methyltransferase MyAD_10680 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) MyAD_10700 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) MyAD_10710 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) MyAD_10715 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) MyAD_10735 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) MyAD_10760 ENOG4105CCU oxidase (Subunit III) MyAD_10770 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) MyAD_10790 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) MyAD_10795 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) MyAD_10800 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY MyAD_10810 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) MyAD_10815 ENOG4105DZ1 carboxypeptidase MyAD_10820 ENOG4105DZ1 carboxypeptidase MyAD_10825 ENOG4105CAQ asparagine synthetase MyAD_10830 ENOG4105D9M gamma-glutamylcysteine synthetase MyAD_10835 ENOG4105DER m42 family MyAD_10845 ENOG4105K5M 30s ribosomal protein S16 MyAD_10855 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) MyAD_10875 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) MyAD_10900 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) MyAD_10910 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F MyAD_10915 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_10920 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) MyAD_10970 ENOG4105C0P Mg chelatase subunit ChlI MyAD_10985 ENOG4105DMF Dehydrogenase MyAD_10990 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) MyAD_11000 ENOG4105CE9 30S ribosomal protein S2 MyAD_11005 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) MyAD_11010 ENOG4105DV0 amidase (EC 3.5.1.4 MyAD_11025 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) MyAD_11030 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) MyAD_11040 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs MyAD_11050 ENOG4107QK4 glycoside hydrolase, family 3 domain protein MyAD_11060 ENOG4105CUB amino acid MyAD_11080 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) MyAD_11085 ENOG4105DZP Membrane-associated zinc metalloprotease MyAD_11095 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) MyAD_11100 ENOG4105CJN penicillin-binding protein MyAD_11115 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) MyAD_11135 ENOG4108Z86 Glutamine amidotransferase MyAD_11140 ENOG4105C26 Dehydrogenase MyAD_11145 ENOG4105H9W Short-chain dehydrogenase reductase Sdr MyAD_11150 ENOG41073TP transcriptional regulator MyAD_11160 ENOG4105D9G High-affinity MyAD_11175 ENOG4105DWT malate dehydrogenase (quinone) MyAD_11200 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) MyAD_11215 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) MyAD_11230 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) MyAD_11240 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) MyAD_11245 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) MyAD_11250 ENOG4105SFS phosphoesterase RecJ domain protein MyAD_11265 ENOG4108IY8 ABC, transporter MyAD_11275 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component MyAD_11280 ENOG4105ETE Transcriptional regulator (LacI family MyAD_11300 ENOG4105BZW Glycerate kinase MyAD_11305 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) MyAD_11310 ENOG4105CNN ABC, transporter MyAD_11320 ENOG4107RHR regulatoR MyAD_11325 ENOG4105EF1 ribulokinase MyAD_11330 ENOG4107WTH Galactitol-1-phosphate dehydrogenase MyAD_11335 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator MyAD_11340 ENOG4105E39 Enoyl-CoA hydratase MyAD_11375 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) MyAD_11395 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) MyAD_11405 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) MyAD_11410 ENOG4105C1V Peptidase, M16 MyAD_11420 ENOG4105DCF alanine dehydrogenase MyAD_11445 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) MyAD_11470 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) MyAD_11480 ENOG4105T0Z Conserved Protein MyAD_11485 ENOG4105BZU Histidine kinase MyAD_11490 ENOG4105EMU Dehydrogenase MyAD_11520 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) MyAD_11525 ENOG4105CN5 Metallo-Beta-Lactamase MyAD_11545 ENOG4105CHH sulfate transporter MyAD_11550 ENOG4107QZI cell division protein FtsK MyAD_11565 ENOG4105WBV Transcriptional regulator MyAD_11585 ENOG4105MXB limonene-12-epoxide hydrolase MyAD_11605 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) MyAD_11610 ENOG4105KC9 Modulates RecA activity (By similarity) MyAD_11625 ENOG4105F6U Short-chain dehydrogenase reductase Sdr MyAD_11635 ENOG4105C2C drug resistance transporter, Bcr CflA MyAD_11640 ENOG4105DRP amino acid AbC transporter MyAD_11645 ENOG4108Q1T ABC transporter MyAD_11650 ENOG4107UBR Extracellular solute-binding protein family 3 MyAD_11655 ENOG4105CDA abc transporter atp-binding protein MyAD_11660 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) MyAD_11670 ENOG4105C99 atpase involved in dna repair MyAD_11675 ENOG4105PP6 Membrane MyAD_11685 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) MyAD_11690 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) MyAD_11695 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) MyAD_11715 ENOG4105D2B acyl-CoA dehydrogenase MyAD_11725 ENOG4108J2R molybdopterin oxidoreductase MyAD_11730 ENOG4105C1G acyl-Coa dehydrogenase MyAD_11740 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) MyAD_11745 ENOG4108ZHJ Organic hydroperoxide resistance protein MyAD_11750 ENOG4105K56 Transcriptional regulator MyAD_11760 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) MyAD_11835 ENOG4107EXU Short-chain dehydrogenase reductase Sdr MyAD_11870 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) MyAD_11900 ENOG4107VEG TrkA-N domain protein MyAD_11905 ENOG4105C0X amino acid MyAD_11910 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) MyAD_11935 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) MyAD_11940 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) MyAD_11960 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) MyAD_11970 ENOG4107JTW chlorite dismutase MyAD_11975 ENOG4105BZU Histidine kinase MyAD_11980 ENOG4105E0X reductase MyAD_11985 ENOG4108P2G integral membrane protein MyAD_11995 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) MyAD_12040 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) MyAD_12095 ENOG4105DQ6 Transposase MyAD_12155 ENOG4107XC4 flavin reductase domain protein, FMN-binding MyAD_12175 ENOG4105CPU Monooxygenase MyAD_12180 ENOG4105CPU Monooxygenase MyAD_12190 ENOG4107QRI Phosphoketolase MyAD_12205 ENOG4105PMW Domain of unknown function (DUF1990) MyAD_12220 ENOG4105C22 threonyL-tRNA synthetase MyAD_12230 ENOG4108VTU Cdp-alcohol phosphatidyltransferase MyAD_12235 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase MyAD_12240 ENOG4105E2K Glycosyl transferase (Group 1 MyAD_12245 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) MyAD_12250 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) MyAD_12255 ENOG4105C29 acyl-CoA thioesterase MyAD_12260 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) MyAD_12265 ENOG4105C1G acyl-Coa dehydrogenase MyAD_12270 ENOG4105CDY transcriptional regulatory protein MyAD_12280 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) MyAD_12285 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) MyAD_12290 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) MyAD_12320 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) MyAD_12325 ENOG4108NY6 Extracellular solute-binding protein, family 5 MyAD_12330 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) MyAD_12335 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) MyAD_12345 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) MyAD_12355 ENOG4107R36 histidyl-tRNA synthetase MyAD_12360 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) MyAD_12365 ENOG4108IV0 ABC, transporter MyAD_12370 ENOG4105C0Z ABC transporter MyAD_12380 ENOG4105C32 Amino acid ABC transporter (Permease) MyAD_12385 ENOG41083Z3 extracellular ligand-binding receptor MyAD_12415 ENOG4108Q5F Tetr family transcriptional regulator MyAD_12440 ENOG4105EBR Carboxylesterase MyAD_12450 ENOG4105C9M aspartyl-trna synthetase MyAD_12460 ENOG4105CHU acetyl-coa acetyltransferase MyAD_12530 ENOG4107ZED Uncharacterised protein family UPF0047 MyAD_12535 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) MyAD_12540 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) MyAD_12550 ENOG4105E2X shikimate dehydrogenase MyAD_12560 ENOG4105BZW Glycerate kinase MyAD_12565 ENOG4105ETE Transcriptional regulator (LacI family MyAD_12600 ENOG4105D49 3-dehydroquinate synthase MyAD_12610 ENOG4105DC7 peptidase M24 MyAD_12615 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) MyAD_12620 ENOG410803B Involved in the transcription termination process (By similarity) MyAD_12630 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MyAD_12650 ENOG41080U6 GntR family transcriptional regulator MyAD_12685 ENOG4105CSH Transporter MyAD_12690 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) MyAD_12695 ENOG4105CXT aspartate transcarbamylase MyAD_12710 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain MyAD_12715 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain MyAD_12720 ENOG4105SKN orotidine 5''-phosphate decarboxylase MyAD_12735 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) MyAD_12745 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP MyAD_12750 ENOG4105F95 Monooxygenase MyAD_12780 ENOG4108V0P LemA family MyAD_12785 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) MyAD_12875 ENOG41064B9 (LipO)protein MyAD_12895 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) MyAD_12900 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) MyAD_12910 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) MyAD_12920 ENOG410783G MyAD_12925 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) MyAD_12930 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) MyAD_12935 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) MyAD_12945 ENOG4105CIE May be required for sporulation (By similarity) MyAD_12950 ENOG4105BZ1 (ABC) transporter MyAD_12955 ENOG4105N82 Endonuclease MyAD_12960 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase MyAD_12965 ENOG4105BZA Phosphoglycerate kinase MyAD_12970 ENOG4105CP7 Triose-phosphate isomerase MyAD_12980 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) MyAD_13015 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) MyAD_13025 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) MyAD_13040 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein MyAD_13055 ENOG4108IJ9 (ABC) transporter MyAD_13060 ENOG4105EG2 ABC transporter, permease MyAD_13075 ENOG4108R85 Short chain dehydrogenase MyAD_13080 ENOG4105CMG Carbohydrate kinase MyAD_13085 ENOG4106P19 photosystem i assembly btpa MyAD_13095 ENOG4105E98 transcriptional regulator DeoR family MyAD_13120 ENOG4107JC6 Membrane MyAD_13140 ENOG4105C3K feS assembly ATPase SufC MyAD_13150 ENOG4108UNV SUF system FeS assembly protein, NifU family MyAD_13155 ENOG4105VG1 fes assembly suf system protein MyAD_13165 ENOG41080RH Thioredoxin MyAD_13175 ENOG4105C5H ABC transporter MyAD_13185 ENOG4108Q5F Tetr family transcriptional regulator MyAD_13190 ENOG4107QM5 aconitate hydratase MyAD_13200 ENOG4105ZXU NLP P60 protein MyAD_13210 ENOG4105C7R Atpase associated with various cellular activities aaa_3 MyAD_13220 ENOG4107QVM von Willebrand factor, type A MyAD_13225 ENOG4105CPC Aldo Keto reductase MyAD_13230 ENOG4105CF7 AraC family transcriptional regulator MyAD_13235 ENOG4105CHR reductase MyAD_13240 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH MyAD_13245 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) MyAD_13355 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) MyAD_13360 ENOG410848D S4 domain protein YaaA MyAD_13370 ENOG4105HDK L-asparaginase MyAD_13395 ENOG4105C6Y Udp-glucose 6-dehydrogenase MyAD_13435 ENOG4107SWG transcriptional regulator MERR family MyAD_13475 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) MyAD_13490 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) MyAD_13495 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) MyAD_13500 ENOG41066NP positive regulation by symbiont of host immune response MyAD_13535 ENOG4105C26 Dehydrogenase MyAD_13600 ENOG4108JB9 formate dehydrogenase MyAD_13605 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_13610 ENOG4105E3J oxidoreductase MyAD_13650 ENOG410829K Lysine exporter protein (Lyse ygga) MyAD_13660 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) MyAD_13665 ENOG4105CIH Imidazole acetol-phosphate transaminase MyAD_13670 ENOG4105ECC imidazole-glycerol-phosphate dehydratase MyAD_13680 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase MyAD_13685 ENOG4108MWI inositol mono-phosphatase MyAD_13690 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) MyAD_13695 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase MyAD_13710 ENOG4105DKW ABC transporter MyAD_13720 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) MyAD_13730 ENOG4105CRQ synthase (Component I) MyAD_13740 ENOG4105DK0 Indole-3-glycerol phosphate synthase MyAD_13750 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) MyAD_13770 ENOG4107QND Nitrite extrusion protein MyAD_13775 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) MyAD_13795 ENOG4105C01 Dihydroxy-acid dehydratase MyAD_13810 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) MyAD_13820 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) MyAD_13840 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) MyAD_13845 ENOG4105CVJ phosphoglycerate mutase MyAD_13865 ENOG4105C8N cysteinyl-tRNA synthetase MyAD_13870 ENOG4108BAS reductase MyAD_13880 ENOG4105C3R Methionine synthase MyAD_13890 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 MyAD_13905 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase MyAD_13910 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) MyAD_13950 ENOG4105MHT Transcriptional regulator, ARSR family MyAD_13980 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) MyAD_14010 ENOG4106F60 Histidine kinase MyAD_14015 ENOG4105ETX regulatoR MyAD_14020 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase MyAD_14025 ENOG4108JPW Aminotransferase MyAD_14030 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) MyAD_14035 ENOG4105EV8 ectoine hydroxylase MyAD_14040 ENOG4105E5F proteasome MyAD_14050 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) MyAD_14055 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) MyAD_14060 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) MyAD_14070 ENOG4107TMB Transcriptional regulator MyAD_14075 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) MyAD_14110 ENOG4108RG3 short-chain dehydrogenase reductase MyAD_14155 ENOG4105CTK cobaltochelatase, cobn subunit MyAD_14195 ENOG4107R05 Transfers the fatty acyl group on membrane lipoproteins (By similarity) MyAD_14200 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) MyAD_14205 ENOG4105Q70 MyAD_14220 ENOG4105EBR Carboxylesterase MyAD_14235 ENOG4105KK4 UPF0060 membrane protein MyAD_14250 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family MyAD_14255 ENOG4105C6Z Gluconate MyAD_14265 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) MyAD_14275 ENOG4105D38 putrescine abc transporter MyAD_14280 ENOG4105F38 ABC transporter, permease MyAD_14300 ENOG4105CIR epoxide hydrolase MyAD_14315 ENOG4108VWS Yaeq family MyAD_14320 ENOG4108UMI ABC transporter, permease MyAD_14325 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) MyAD_14330 ENOG4105D01 (LipO)protein MyAD_14335 ENOG4105CPU Monooxygenase MyAD_14345 ENOG4105CHR reductase MyAD_14390 ENOG4105C7F AcnD-accessory protein PrpF MyAD_14405 ENOG4105C7F AcnD-accessory protein PrpF MyAD_14410 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) MyAD_14425 ENOG4105BZU Histidine kinase MyAD_14435 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease MyAD_14440 ENOG410633P Hydantoin racemase MyAD_14445 ENOG4105S0E allantoin catabolism protein MyAD_14455 ENOG41069M3 Transcriptional regulator MyAD_14490 ENOG4105EVH UPF0753 protein MyAD_14520 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) MyAD_14530 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MyAD_14540 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein MyAD_14545 ENOG4105C57 major facilitator superfamily MyAD_14575 ENOG4108Q5F Tetr family transcriptional regulator MyAD_14595 ENOG4105DQ6 Transposase MyAD_14615 ENOG4106FC9 Protein of unknown function (DUF3018) MyAD_14620 ENOG4105NFY transcriptional modulator of maze toxin, mazf MyAD_14630 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) MyAD_14635 ENOG4108IG5 Transcriptional regulator MyAD_14675 ENOG4105C1G acyl-Coa dehydrogenase MyAD_14765 ENOG4105C1G acyl-Coa dehydrogenase MyAD_14775 ENOG4105C57 major facilitator superfamily MyAD_14815 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) MyAD_14825 ENOG4105WEF catalase MyAD_14845 ENOG41081K0 peptidylprolyl cis-trans isomerase MyAD_14890 ENOG4105VEQ Cold shock protein MyAD_14925 ENOG4106A3M Cytochrome p-450 MyAD_14965 ENOG4105DJ2 Major Facilitator Superfamily MyAD_14970 ENOG4105JXH GntR family transcriptional regulator MyAD_14980 ENOG4107XFJ UPF0246 protein MyAD_15025 ENOG4105CEV competence damage-inducible protein MyAD_15080 ENOG4108HIZ formate dehydrogenase alpha subunit MyAD_15110 ENOG4105ETX regulatoR MyAD_15115 ENOG4105BZU Histidine kinase MyAD_15155 ENOG4105DUX Transporter MyAD_15190 ENOG4105D01 (LipO)protein MyAD_15195 ENOG4107NHD transcriptional regulator MyAD_15205 ENOG4108MJN Glycosyl Transferase MyAD_15255 ENOG4105E39 Enoyl-CoA hydratase MyAD_15275 ENOG4105DRR Transcriptional regulator, GntR family MyAD_15285 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) MyAD_15325 ENOG4105CEP NADH dehydrogenase MyAD_15335 ENOG4105D64 Mechanosensitive ion channel MyAD_15350 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) MyAD_15355 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone MyAD_15380 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) MyAD_15430 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone MyAD_15435 ENOG4105CEP NADH dehydrogenase MyAD_15445 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) MyAD_15460 ENOG4105CQM Urea amidohydrolase subunit alpha MyAD_15465 ENOG4105KI2 Urea amidohydrolase subunit beta MyAD_15470 ENOG4108YZ9 Urea amidohydrolase subunit gamma MyAD_15495 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) MyAD_15505 ENOG4105C37 (CBS) domain MyAD_15510 ENOG4107UAX integral membrane protein MyAD_15540 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor MyAD_15560 ENOG4108UW8 fha domain-containing protein MyAD_15565 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) MyAD_15600 ENOG4107EFR Flavocytochrome c MyAD_15630 ENOG4105CJP fad dependent oxidoreductase MyAD_15640 ENOG4105EBR Carboxylesterase MyAD_15650 ENOG410814C multidrug resistance protein MyAD_15720 ENOG4105C26 Dehydrogenase MyAD_15725 ENOG4108SC4 )-transporter MyAD_15755 ENOG4105XTG Pfam:DUF156 MyAD_15775 ENOG4105C1G acyl-Coa dehydrogenase MyAD_15805 ENOG4105CHH sulfate transporter MyAD_15860 ENOG4107QN2 dihydrolipoyl dehydrogenase MyAD_15875 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) MyAD_15880 ENOG4108JJB ABC transporter MyAD_15885 ENOG4107ZYJ bioY protein MyAD_15890 ENOG4105DU1 integral membrane protein, terc MyAD_15895 ENOG4107SFI Major Facilitator superfamily MyAD_15910 ENOG4107S5I aldo keto reductase MyAD_15935 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) MyAD_15940 ENOG4108J2P Alpha beta hydrolase fold MyAD_15960 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) MyAD_16010 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) MyAD_16035 ENOG4105C1G acyl-Coa dehydrogenase MyAD_16040 ENOG4108RZE Tetr family transcriptional regulator MyAD_16045 ENOG4105CHU acetyl-coa acetyltransferase MyAD_16060 ENOG4105CYC Transferase MyAD_16075 ENOG4105C26 Dehydrogenase MyAD_16080 ENOG41061TZ Short-chain dehydrogenase reductase Sdr MyAD_16105 ENOG4105CVN desaturase MyAD_16125 ENOG4105CI0 Citrate lyase MyAD_16160 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_16165 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_16170 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr MyAD_16175 ENOG4105CHU acetyl-coa acetyltransferase MyAD_16185 ENOG4105CHU acetyl-coa acetyltransferase MyAD_16200 ENOG4105FUY alpha subunit MyAD_16205 ENOG4105CGU Enoyl-CoA hydratase MyAD_16210 ENOG4105E39 Enoyl-CoA hydratase MyAD_16225 ENOG4105CHR reductase MyAD_16275 ENOG4105DJG MaoC domain protein dehydratase MyAD_16355 ENOG4105F38 ABC transporter, permease MyAD_16360 ENOG4105D38 putrescine abc transporter MyAD_16365 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) MyAD_16395 ENOG4106UW1 Major Facilitator superfamily MyAD_16405 ENOG4105C26 Dehydrogenase MyAD_16415 ENOG4105DND Transcriptional regulator MyAD_16420 ENOG4105C8Y Acetylornithine aminotransferase MyAD_16440 ENOG4108JPW Aminotransferase MyAD_16445 ENOG4105C26 Dehydrogenase MyAD_16465 ENOG4105G63 Type III effector Hrp-dependent MyAD_16470 ENOG4105FB2 class II Aldolase MyAD_16475 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) MyAD_16490 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) MyAD_16500 ENOG4105CUB amino acid MyAD_16510 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr MyAD_16515 ENOG4105WH1 Two component transcriptional regulator luxr family MyAD_16525 ENOG4105F27 Major Facilitator MyAD_16530 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) MyAD_16535 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 MyAD_16540 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F MyAD_16555 ENOG4105CHR reductase MyAD_16560 ENOG4105KRG Aromatic-ring-hydroxylating dioxygenase beta subunit MyAD_16570 ENOG4105FUY alpha subunit MyAD_16580 ENOG4105FUY alpha subunit MyAD_16585 ENOG4105KRG Aromatic-ring-hydroxylating dioxygenase beta subunit MyAD_16595 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) MyAD_16600 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) MyAD_16620 ENOG4105C1G acyl-Coa dehydrogenase MyAD_16625 ENOG4105C1G acyl-Coa dehydrogenase MyAD_16630 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) MyAD_16650 ENOG4105DQ4 alcohol dehydrogenase MyAD_16655 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_16660 ENOG4107TTQ Alpha beta hydrolase fold MyAD_16675 ENOG4105DQ6 Transposase MyAD_16690 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein MyAD_16695 ENOG410635A Membrane MyAD_16705 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) MyAD_16710 ENOG4105CAT Cytidine monophosphate kinase MyAD_16720 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) MyAD_16745 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) MyAD_16795 ENOG4105DSU hydrolase MyAD_16825 ENOG4108VX5 3-methyladenine DNA glycosylase MyAD_16830 ENOG4105W49 UPF0434 protein MyAD_16845 ENOG4105C5H ABC transporter MyAD_16850 ENOG4105CH7 arginosuccinase MyAD_16855 ENOG4105CDH Citrulline--aspartate ligase MyAD_16865 ENOG4105DBV ornithine carbamoyltransferase MyAD_16870 ENOG4105C8Y Acetylornithine aminotransferase MyAD_16875 ENOG4105CAS nag kinase MyAD_16880 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) MyAD_16885 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase MyAD_16890 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) MyAD_16895 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) MyAD_16910 ENOG4105C1G acyl-Coa dehydrogenase MyAD_16920 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) MyAD_16925 ENOG41084BS 50S ribosomal protein L35 MyAD_16940 ENOG4105CRK lysyL-tRNA synthetase MyAD_16990 ENOG4105C5X domain protein MyAD_17005 ENOG4108J08 Csbd family MyAD_17105 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) MyAD_17125 ENOG4105DND Transcriptional regulator MyAD_17130 ENOG41061H0 Monooxygenase MyAD_17150 ENOG41063C6 UPF0235 protein MyAD_17155 ENOG4108IV0 ABC, transporter MyAD_17160 ENOG4105C0Z ABC transporter MyAD_17165 ENOG4105CF8 branched-chain amino acid ABC transporter, permease MyAD_17170 ENOG4105C32 Amino acid ABC transporter (Permease) MyAD_17190 ENOG4105EN6 Membrane MyAD_17210 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction MyAD_17240 ENOG4105EAB amino acid AbC transporter MyAD_17250 ENOG4105C4M (Ubiquinol oxidase) subunit I MyAD_17255 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii MyAD_17260 ENOG4108JJ9 ABC, transporter MyAD_17265 ENOG4108JJ8 (ABC) transporter MyAD_17275 ENOG4105C29 acyl-CoA thioesterase MyAD_17290 ENOG4105CBC glutamate synthase MyAD_17305 ENOG4105DWT malate dehydrogenase (quinone) MyAD_17310 ENOG4105C5Q Transcriptional regulator MyAD_17350 ENOG4105SHT UspA domain-containing protein MyAD_17365 ENOG4105JN3 extra-cytoplasmic solute receptor family protein MyAD_17370 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism MyAD_17375 ENOG4108MRH transcriptional regulatory protein MyAD_17380 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) MyAD_17405 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) MyAD_17425 ENOG4105ME9 cell division protein FtsQ MyAD_17430 ENOG4105DFU Cell wall formation (By similarity) MyAD_17435 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) MyAD_17455 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) MyAD_17460 ENOG4105CJN penicillin-binding protein MyAD_17470 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) MyAD_17475 ENOG4108V6E Cell division protein mraZ MyAD_17490 ENOG4105R14 (LipO)protein MyAD_17500 ENOG41090CE integral membrane protein MyAD_17505 ENOG4105KYH transcriptional regulatory protein MyAD_17515 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase MyAD_17530 ENOG4108VJY integral membrane protein MyAD_17545 ENOG4105D0U Arsenite-activated ATPase (ArsA) MyAD_17560 ENOG4108IQE Amp-dependent synthetase and ligase MyAD_17565 ENOG4105JNK Glycosyl transferase (Group 1 MyAD_17590 ENOG4105CCU oxidase (Subunit III) MyAD_17625 ENOG4108ZRS Part of cytochrome c oxidase, its function is MyAD_17670 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) MyAD_17675 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) MyAD_17680 ENOG4105CNG UPF0061 protein MyAD_17690 ENOG4105CM2 brancheD-chain amino acid aminotransferase MyAD_17730 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) MyAD_17735 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) MyAD_17755 ENOG4105C5F glutamine synthetase MyAD_17780 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) MyAD_17785 ENOG4105C5F glutamine synthetase MyAD_17805 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) MyAD_17810 ENOG4108UKI Enoyl-CoA hydratase MyAD_17825 ENOG4108JU3 Alkyl hydroperoxide reductase MyAD_17835 ENOG4105CVJ phosphoglycerate mutase MyAD_17930 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) MyAD_17940 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase MyAD_17945 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) MyAD_17965 ENOG4107EXU Short-chain dehydrogenase reductase Sdr MyAD_17970 ENOG4105DND Transcriptional regulator MyAD_18005 ENOG4107S1E Beta-lactamase MyAD_18015 ENOG4105C5X domain protein MyAD_18055 ENOG4108R85 Short chain dehydrogenase MyAD_18070 ENOG4107QUV Domain protein MyAD_18075 ENOG4105C7N Xanthine uracil vitamin C permease MyAD_18100 ENOG4105BZU Histidine kinase MyAD_18120 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) MyAD_18150 ENOG4105DQ6 Transposase MyAD_18180 ENOG4105E5Q amino acid AbC transporter MyAD_18185 ENOG4105E5Q amino acid AbC transporter MyAD_18200 ENOG4105CXK mandelate racemase muconate lactonizing MyAD_18210 ENOG4105D7K pfkb domain protein MyAD_18230 ENOG4105MWK D-amino acid dehydrogenase, small subunit MyAD_18255 ENOG4105DXB Major Facilitator superfamily MyAD_18295 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) MyAD_18300 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein MyAD_18320 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) MyAD_18345 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) MyAD_18350 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) MyAD_18380 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) MyAD_18395 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) MyAD_18400 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) MyAD_18430 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_18440 ENOG4107EEY synthase MyAD_18455 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase MyAD_18485 ENOG4108RZE Tetr family transcriptional regulator MyAD_18505 ENOG4105ECW sulfate abc transporter MyAD_18510 ENOG4108I5D sulfate abc transporter MyAD_18515 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein MyAD_18530 ENOG4105BZP glycoside hydrolase 15-related MyAD_18545 ENOG4105C9B Cysteine desulfurase MyAD_18570 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) MyAD_18580 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) MyAD_18590 ENOG4108UMI ABC transporter, permease MyAD_18605 ENOG4105E0A ABC, transporter MyAD_18610 ENOG4105EHG Permease protein MyAD_18630 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) MyAD_18635 ENOG4107XDQ Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) MyAD_18655 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) MyAD_18670 ENOG4105KQC Competence protein MyAD_18675 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase MyAD_18705 ENOG4108TZC MyAD_18710 ENOG4105CVJ phosphoglycerate mutase MyAD_18715 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) MyAD_18720 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) MyAD_18730 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit MyAD_18735 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) MyAD_18740 ENOG4108RVA ribokinase MyAD_18775 ENOG4107W19 lmbE family MyAD_18780 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) MyAD_18785 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control MyAD_18790 ENOG4105K46 50S ribosomal protein l27 MyAD_18795 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) MyAD_18800 ENOG4105C03 ribonuclease MyAD_18805 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) MyAD_18815 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase MyAD_18820 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) MyAD_18825 ENOG4105EG6 Saccharopine dehydrogenase MyAD_18830 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein MyAD_18875 ENOG41080AZ Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) MyAD_18880 ENOG4105DQU oxidoreductase, subunit beta MyAD_18885 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein MyAD_18895 ENOG4105ETE Transcriptional regulator (LacI family MyAD_18900 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) MyAD_18905 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) MyAD_18915 ENOG4105C2J ABC transporter MyAD_18920 ENOG41062B0 ABC transporter, permease MyAD_18930 ENOG4105FDP GntR family transcriptional regulator MyAD_18935 ENOG4105EDK PfkB domain protein MyAD_18945 ENOG4105DH8 myo-inositol catabolism MyAD_18950 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) MyAD_18970 ENOG4105C5Q Transcriptional regulator MyAD_18980 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) MyAD_18985 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) MyAD_18995 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) MyAD_19000 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) MyAD_19005 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation MyAD_19030 ENOG4106CY5 excisionase MyAD_19040 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) MyAD_19155 ENOG4105EMU Dehydrogenase MyAD_19175 ENOG4105CJW magnesium transporter MyAD_19180 ENOG4105MC2 DSBA oxidoreductase MyAD_19195 ENOG4109057 MyAD_19215 ENOG4105CG3 alpha amylase, catalytic region MyAD_19230 ENOG4105C7I Dehydrogenase MyAD_19285 ENOG4105BZU Histidine kinase MyAD_19320 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 MyAD_19345 ENOG4105C1G acyl-Coa dehydrogenase MyAD_19355 ENOG4107QX3 carboxylase MyAD_19380 ENOG4105D7A ATP-binding protein MyAD_19385 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) MyAD_19420 ENOG41069M3 Transcriptional regulator MyAD_19430 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_19495 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) MyAD_19500 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) MyAD_19515 ENOG4105C1G acyl-Coa dehydrogenase MyAD_19520 ENOG4105CHU acetyl-coa acetyltransferase MyAD_19525 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F MyAD_19620 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) MyAD_19625 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) MyAD_19655 ENOG4105KXX peptidase s58 dmpa MyAD_19665 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) MyAD_19670 ENOG4107RKP Nicotinate phosphoribosyltransferase MyAD_19685 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid MyAD_19690 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) MyAD_19695 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) MyAD_19700 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) MyAD_19710 ENOG4105EYF MMPL domain protein MyAD_19715 ENOG4105CHU acetyl-coa acetyltransferase MyAD_19730 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) MyAD_19740 ENOG4105CSV Glutaminase MyAD_19755 ENOG4107T5V SNARE associated Golgi MyAD_19765 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) MyAD_19785 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) MyAD_19800 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) MyAD_19805 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) MyAD_19810 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) MyAD_19815 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) MyAD_19820 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) MyAD_19825 ENOG4105V1A F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) MyAD_19830 ENOG410679R F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) MyAD_19835 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) MyAD_19845 ENOG4105ESV Glycosyl transferase, family 4 MyAD_19855 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) MyAD_19860 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) MyAD_19865 ENOG4105VFB Binds the 23S rRNA (By similarity) MyAD_19870 ENOG4105J5T Amp-dependent synthetase and ligase MyAD_19875 ENOG4108IG5 Transcriptional regulator MyAD_19885 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) MyAD_19890 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) MyAD_19895 ENOG4105D6E homoserine dehydrogenase MyAD_19900 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) MyAD_19905 ENOG4105C75 arginyL-tRNA synthetase MyAD_19915 ENOG4105J7D transcriptional regulator MyAD_19945 ENOG4105WH1 Two component transcriptional regulator luxr family MyAD_19965 ENOG4105CQB FAD linked oxidase domain protein MyAD_19985 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo MyAD_19995 ENOG4105C11 sulfate adenylyltransferase), subunit 2 MyAD_20000 ENOG4105EDW glycosyl transferase, family 39 MyAD_20010 ENOG4105EDW glycosyl transferase, family 39 MyAD_20015 ENOG4105BZU Histidine kinase MyAD_20020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MyAD_20055 ENOG4107T8P acyl-Coa dehydrogenase MyAD_20090 ENOG4105BZ1 (ABC) transporter MyAD_20145 ENOG4105DEN Luciferase family MyAD_20165 ENOG4105CQB FAD linked oxidase domain protein MyAD_20230 ENOG4105C2C drug resistance transporter, Bcr CflA MyAD_20240 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 MyAD_20265 ENOG4105D7N magnesium and cobalt transport protein CorA MyAD_20315 ENOG4105CJW magnesium transporter MyAD_20335 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) MyAD_20340 ENOG4105C0H protease MyAD_20345 ENOG4106684 MyAD_20350 ENOG4105DU6 RNA polymerase MyAD_20365 ENOG4108X07 Tetr family transcriptional regulator MyAD_20370 ENOG4105CIG ABC transporter MyAD_20375 ENOG4105DIM ABC transporter MyAD_20390 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) MyAD_20395 ENOG4107QPH glycogen) synthase MyAD_20400 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) MyAD_20410 ENOG4105C3Q Glycosyl transferase, family 2 MyAD_20425 ENOG4108URH decarboxylase MyAD_20445 ENOG4107R4C succinyl-diaminopimelate desuccinylase MyAD_20450 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) MyAD_20460 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_20475 ENOG41062BK proline dehydrogenase MyAD_20480 ENOG4105C26 Dehydrogenase MyAD_20500 ENOG4108Z4U Ferredoxin MyAD_20510 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase MyAD_20515 ENOG4108YYC ycei family MyAD_20525 ENOG4105CHR reductase MyAD_20570 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) MyAD_20580 ENOG4105CMT Dihydroxyacetone kinase MyAD_20585 ENOG4107USK Extracellular solute-binding protein, family 5 MyAD_20600 ENOG4105CI3 gtp-binding protein typa MyAD_20620 ENOG4108U8T Mannosyltransferase MyAD_20645 ENOG4105CH2 amidohydrolase MyAD_20655 ENOG4108HRK Histidine kinase MyAD_20660 ENOG4105DY9 regulatoR MyAD_20680 ENOG4107QN1 sodium solute MyAD_20695 ENOG410905P Pyridoxamine 5-phosphate MyAD_20710 ENOG4105CT3 Monooxygenase MyAD_20725 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) MyAD_20740 ENOG4107R13 MMPL domain protein MyAD_20745 ENOG4105EA8 2-Nitropropane dioxygenase MyAD_20755 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F MyAD_20760 ENOG4108UKI Enoyl-CoA hydratase MyAD_20775 ENOG4105CGD Nad-dependent epimerase dehydratase MyAD_20785 ENOG4105ECQ AraC Family Transcriptional Regulator MyAD_20790 ENOG4105DCM major facilitator superfamily MyAD_20795 ENOG410906A Beta-Ig-H3 fasciclin MyAD_20810 ENOG4105CHU acetyl-coa acetyltransferase MyAD_20815 ENOG41073TP transcriptional regulator MyAD_20825 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) MyAD_20970 ENOG4105C3G gtp-binding protein MyAD_21055 ENOG4108IAB Phoh family MyAD_21065 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) MyAD_21090 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) MyAD_21105 ENOG4105C7Z Conserved Protein MyAD_21115 ENOG4105T1M mycothiol conjugate amidase mca MyAD_21125 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) MyAD_21150 ENOG4105W8D rdd domain containing protein MyAD_21170 ENOG4105CHU acetyl-coa acetyltransferase MyAD_21175 ENOG4107SPG Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR MyAD_21190 ENOG4105E39 Enoyl-CoA hydratase MyAD_21230 ENOG4108KR4 dihydrodipicolinate reductase MyAD_21265 ENOG4108MRH transcriptional regulatory protein MyAD_21270 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism MyAD_21275 ENOG4107QJT sodium dicarboxylate symporter MyAD_21290 ENOG4105CDA abc transporter atp-binding protein MyAD_21295 ENOG4105E5Q amino acid AbC transporter MyAD_21345 ENOG4105C26 Dehydrogenase MyAD_21365 ENOG4105C85 amino acid MyAD_21375 ENOG4108QDE fad dependent oxidoreductase MyAD_21460 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) MyAD_21465 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) MyAD_21495 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) MyAD_21500 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) MyAD_21515 ENOG4105C59 p-type ATPase MyAD_21520 ENOG41066UM arsR family transcriptional regulator MyAD_21550 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) MyAD_21565 ENOG4105DBE peroxidase MyAD_21585 ENOG4105DBE peroxidase MyAD_21600 ENOG4107UWP Major facilitator superfamily MFS_1 MyAD_21610 ENOG4108M8W Monooxygenase MyAD_21635 ENOG4105MXW flavin reductase domain protein, FMN-binding MyAD_21645 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_21655 ENOG4105DXN mazG family MyAD_21675 ENOG4108IG5 Transcriptional regulator MyAD_21685 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) MyAD_21710 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) MyAD_21715 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) MyAD_21725 ENOG4107RCI amp-dependent synthetase and ligase MyAD_21730 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) MyAD_21740 ENOG4106839 domain protein MyAD_21745 ENOG4105F8V Hydrolase, tatD family MyAD_21755 ENOG4105D82 Glutamate dehydrogenase MyAD_21760 ENOG4108UYU AsnC family transcriptional regulator MyAD_21765 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase MyAD_21775 ENOG4105CRQ synthase (Component I) MyAD_21815 ENOG4105CEU Arginine dihydrolase MyAD_21820 ENOG4108Z4X TRANSCRIPTIONal MyAD_21845 ENOG4105F9E Shikimate 5-dehydrogenase MyAD_21850 ENOG410870F Cyclic nucleotide-binding protein MyAD_21865 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) MyAD_21880 ENOG4105BZU Histidine kinase MyAD_21900 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) MyAD_21930 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase MyAD_21935 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase MyAD_21965 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) MyAD_21975 ENOG41062D9 Histidine kinase MyAD_21980 ENOG4105ETX regulatoR MyAD_21985 ENOG41067C8 50S ribosomal protein L32 MyAD_22000 ENOG4107QX3 carboxylase MyAD_22015 ENOG41060WC Enoyl-CoA hydratase MyAD_22025 ENOG4107KWJ von Willebrand factor, type A MyAD_22060 ENOG4105FBW Monooxygenase MyAD_22090 ENOG4105CMV Succinyl-CoA synthetase subunit beta MyAD_22095 ENOG4108K5P (LipO)protein MyAD_22120 ENOG4107QP8 phosphohexose isomerase MyAD_22150 ENOG41082T9 Membrane MyAD_22180 ENOG4105F27 Major Facilitator MyAD_22205 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) MyAD_22220 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) MyAD_22225 ENOG4105BZU Histidine kinase MyAD_22235 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) MyAD_22245 ENOG4105DQE DNA ligase MyAD_22250 ENOG4105FDF Could be involved in DNA repair (By similarity) MyAD_22270 ENOG4105CUB amino acid MyAD_22275 ENOG4105EFZ amidohydrolase MyAD_22285 ENOG4105K6V RNA polymerase MyAD_22290 ENOG4105RSG Anti-sigma-K factor RskA MyAD_22310 ENOG4108KQ5 Integrase catalytic subunit MyAD_22350 ENOG4105DQ5 transport system permease protein MyAD_22355 ENOG4105TVJ transport system, permease MyAD_22380 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) MyAD_22385 ENOG4105D3W isochorismatase MyAD_22395 ENOG4105BZU Histidine kinase MyAD_22415 ENOG4105DEF Extracellular solute-binding protein, family 5 MyAD_22425 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MyAD_22430 ENOG4108JQ6 ABC transporter MyAD_22440 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) MyAD_22445 ENOG4105K6V RNA polymerase MyAD_22450 ENOG4105CHU acetyl-coa acetyltransferase MyAD_22500 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic MyAD_22505 ENOG4107S1E Beta-lactamase MyAD_22515 ENOG4108VUG Enoyl-CoA hydratase MyAD_22525 ENOG4105BZU Histidine kinase MyAD_22530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MyAD_22540 ENOG4105MGM doxx family MyAD_22560 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_22565 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) MyAD_22575 ENOG4105BZ1 (ABC) transporter MyAD_22600 ENOG41081K0 peptidylprolyl cis-trans isomerase MyAD_22610 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) MyAD_22665 ENOG4105URP P-aminobenzoate N-oxygenase AurF MyAD_22675 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) MyAD_22750 ENOG4105CHF Glutathione S-transferase MyAD_22755 ENOG4105VEQ Cold shock protein MyAD_22765 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) MyAD_22785 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) MyAD_22830 ENOG4108M8W Monooxygenase MyAD_22845 ENOG4105ECQ AraC Family Transcriptional Regulator MyAD_22850 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase MyAD_22855 ENOG4105CHU acetyl-coa acetyltransferase MyAD_22860 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase MyAD_22870 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein MyAD_22875 ENOG4108F09 Urease subunit gamma beta MyAD_22880 ENOG4105CQM Urea amidohydrolase subunit alpha MyAD_22885 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) MyAD_22890 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) MyAD_22910 ENOG4107QPD alcohol dehydrogenase MyAD_22915 ENOG4105CUB amino acid MyAD_22930 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease MyAD_22940 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone MyAD_23005 ENOG4105EWK phytoene MyAD_23055 ENOG4108DT4 serine threonine protein kinase MyAD_23080 ENOG4108RCF TRANSCRIPTIONal MyAD_23100 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) MyAD_23120 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) MyAD_23125 ENOG4107NHD transcriptional regulator MyAD_23135 ENOG4105N6Y Thioredoxin MyAD_23145 ENOG4105KHC sulfurtransferase MyAD_23150 ENOG4105PKJ carbohydrate binding MyAD_23180 ENOG4105CXB phosphoribosylaminoimidazole synthetase MyAD_23215 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii MyAD_23230 ENOG4105DFM M18 family aminopeptidase MyAD_23235 ENOG4105EZR dyp-type peroxidase family protein MyAD_23255 ENOG410839H phosphoribosylformylglycinamidine synthase MyAD_23280 ENOG4108V06 Glutathione peroxidase MyAD_23290 ENOG4105C8V SAICAR synthetase MyAD_23300 ENOG4105DQ5 transport system permease protein MyAD_23305 ENOG4105TVJ transport system, permease MyAD_23310 ENOG4105E0A ABC, transporter MyAD_23315 ENOG4108MES Periplasmic binding protein MyAD_23330 ENOG4105C83 adenylosuccinate lyase MyAD_23335 ENOG4105DVH amino acid MyAD_23355 ENOG4106A3M Cytochrome p-450 MyAD_23385 ENOG4105C26 Dehydrogenase MyAD_23400 ENOG4105EMU Dehydrogenase MyAD_23405 ENOG41068W2 Cytochrome p-450 MyAD_23435 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_23445 ENOG4105BZU Histidine kinase MyAD_23450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MyAD_23490 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family MyAD_23505 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase MyAD_23540 ENOG4107PE3 Mammalian cell entry related domain protein MyAD_23610 ENOG4105CHR reductase MyAD_23620 ENOG4105X7H acyl-CoA dehydrogenase MyAD_23625 ENOG4108KC2 acyl-Coa dehydrogenase MyAD_23640 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase MyAD_23650 ENOG4108JGH Tetr family transcriptional regulator MyAD_23665 ENOG4106YT9 Enoyl-CoA hydratase MyAD_23685 ENOG4105CSH Transporter MyAD_23695 ENOG4105EEX Two component transcriptional regulator (Winged helix family MyAD_23700 ENOG410719E cytochrome p450 MyAD_23705 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) MyAD_23710 ENOG4105DYW oxidoreductase MyAD_23725 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) MyAD_23730 ENOG4105X1P Steroid delta-isomerase MyAD_23740 ENOG4105CIJ rieske 2fe-2S domain-containing protein MyAD_23755 ENOG4105CHR reductase MyAD_23770 ENOG4105C9U ATP-dependent DNA helicase RecQ MyAD_23790 ENOG4107SCA Formamidase (EC 3.5.1.49) MyAD_23795 ENOG4105DWV Homoserine O-trans-acetylase MyAD_23805 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) MyAD_23810 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) MyAD_23820 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein MyAD_23870 ENOG4105C6Y Udp-glucose 6-dehydrogenase MyAD_23875 ENOG4105C1B dTDP-glucose 4-6-dehydratase MyAD_23915 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) MyAD_23920 ENOG4105PSV Polysaccharide Biosynthesis Protein MyAD_23925 ENOG4105C6Y Udp-glucose 6-dehydrogenase MyAD_23950 ENOG4105CPK Glycosyl transferase (Group 1 MyAD_23965 ENOG4105C1B dTDP-glucose 4-6-dehydratase MyAD_23980 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_23985 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) MyAD_23990 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) MyAD_24025 ENOG410900P UPF0336 protein MyAD_24030 ENOG4105X7H acyl-CoA dehydrogenase MyAD_24035 ENOG4108RK3 acyl-Coa dehydrogenase MyAD_24045 ENOG4105F2C Acetyl-CoA acetyltransferase MyAD_24065 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr MyAD_24075 ENOG4105E39 Enoyl-CoA hydratase MyAD_24090 ENOG4105EA8 2-Nitropropane dioxygenase MyAD_24100 ENOG4105C2W permease MyAD_24115 ENOG41061H0 Monooxygenase MyAD_24120 ENOG4107QUY Guanine deaminase MyAD_24135 ENOG4105CHU acetyl-coa acetyltransferase MyAD_24140 ENOG4108RZE Tetr family transcriptional regulator MyAD_24150 ENOG4105CHR reductase MyAD_24155 ENOG4105CC9 acyl-Coa dehydrogenase MyAD_24160 ENOG4105CEY Amp-dependent synthetase and ligase MyAD_24165 ENOG4105CC9 acyl-Coa dehydrogenase MyAD_24170 ENOG4105D2B acyl-CoA dehydrogenase MyAD_24175 ENOG4105D2B acyl-CoA dehydrogenase MyAD_24205 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) MyAD_24220 ENOG4108R4R Iron-regulated virulence regulatory protein MyAD_24235 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase MyAD_24250 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) MyAD_24260 ENOG4105D2B acyl-CoA dehydrogenase MyAD_24265 ENOG4108SGK Tetr family transcriptional regulator MyAD_24285 ENOG4105CC5 ABC transporter MyAD_24290 ENOG4105FDK ABC transporter MyAD_24300 ENOG4105CKI cobalamin synthesis protein MyAD_24310 ENOG4107XSR periplasmic solute binding protein MyAD_24315 ENOG4105CC5 ABC transporter MyAD_24320 ENOG4105DIK (ABC) transporter MyAD_24325 ENOG4105E7W lamb ycsf family protein MyAD_24340 ENOG4108PJD permease MyAD_24350 ENOG4108A65 Transcriptional regulator MyAD_24360 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase MyAD_24365 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) MyAD_24370 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) MyAD_24375 ENOG4105W0E 50S ribosomal protein L33 MyAD_24390 ENOG4105NRA 50s ribosomal protein l31 type b MyAD_24400 ENOG4107R5R arsenical pump membrane protein MyAD_24405 ENOG4105C2N RNA methyltransferase TrmH family group 3 MyAD_24410 ENOG4105C8N cysteinyl-tRNA synthetase MyAD_24415 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) MyAD_24420 ENOG4108VJ1 Transcriptional regulator (CarD family MyAD_24430 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) MyAD_24435 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) MyAD_24445 ENOG4108V9Q carbonic anhydrase MyAD_24450 ENOG4105CEN a g-specific adenine glycosylase MyAD_24495 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit MyAD_24505 ENOG4105CRK lysyL-tRNA synthetase MyAD_24510 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) MyAD_24515 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) MyAD_24520 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) MyAD_24555 ENOG4105EUJ GTP cyclohydrolase i MyAD_24565 ENOG4105D74 hydrolase MyAD_24575 ENOG4105CPQ Dehydrogenase MyAD_24580 ENOG4105MPN Membrane MyAD_24590 ENOG4108UGV hypoxanthine phosphoribosyltransferase MyAD_24625 ENOG4108JQ1 Dehydrogenase MyAD_24630 ENOG4105EQX glucarate dehydratase MyAD_24635 ENOG4107HP6 Transcriptional regulator MyAD_24645 ENOG4108JQ7 (ABC) transporter MyAD_24650 ENOG4105C3U ABC transporter MyAD_24665 ENOG4105DEF Extracellular solute-binding protein, family 5 MyAD_24670 ENOG4105C5I Dehydrogenase MyAD_24675 ENOG4107RSM transcriptional regulator MyAD_24695 ENOG4105EQX glucarate dehydratase MyAD_24760 ENOG4107QRG dna polymerase iii MyAD_24770 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) MyAD_24780 ENOG4105VEQ Cold shock protein MyAD_24785 ENOG4108I5C dEAD DEAH box helicase MyAD_24840 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) MyAD_24865 ENOG4105P8F nudix hydrolase MyAD_24870 ENOG4105K63 Thioredoxin MyAD_24875 ENOG4105CSM endonuclease III MyAD_24890 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) MyAD_24895 ENOG4105KME endoribonuclease L-psp MyAD_24915 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) MyAD_24925 ENOG4107RGJ metallophosphoesterase MyAD_24955 ENOG4105C29 acyl-CoA thioesterase MyAD_24975 ENOG4108WQ6 secreted protein MyAD_24980 ENOG4105C7R Atpase associated with various cellular activities aaa_3 MyAD_25000 ENOG4105YIP Tetr family transcriptional regulator MyAD_25005 ENOG4105C57 major facilitator superfamily MyAD_25050 ENOG4105ENE Histidine kinase MyAD_25055 ENOG4105C0A alcohol dehydrogenase MyAD_25065 ENOG4106JDQ ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB MyAD_25090 ENOG4105C92 Aminotransferase class V MyAD_25095 ENOG41067HS methyltransferase MyAD_25100 ENOG4108V75 Glutamine amidotransferase MyAD_25105 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process MyAD_25110 ENOG4105D1K glutamate--cysteine ligase MyAD_25135 ENOG4108NJC MyAD_25140 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) MyAD_25145 ENOG4105CFH Aspartokinase MyAD_25160 ENOG4105EYU Glutamine amido-transferase MyAD_25165 ENOG4105M90 Glutamate synthase alpha subunit domain protein MyAD_25170 ENOG4105CBC glutamate synthase MyAD_25220 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) MyAD_25225 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) MyAD_25230 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) MyAD_25240 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) MyAD_25245 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) MyAD_25250 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase MyAD_25265 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase MyAD_25275 ENOG4105XT2 Transcriptional regulator MyAD_25300 ENOG4105DQE DNA ligase MyAD_25305 ENOG4105GN4 DNA ligase MyAD_25310 ENOG4105C1G acyl-Coa dehydrogenase MyAD_25315 ENOG4105C5W Aldolase