locus-tag	class	description
MyAD_00005	COG1793	dna ligase
MyAD_00020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MyAD_00030	COG0765	amino acid transport
MyAD_00035	COG1126	abc transporter atp-binding protein
MyAD_00040	COG0427	acetyl-CoA hydrolase
MyAD_00050	COG0343	queuine tRNA-ribosyltransferase activity
MyAD_00075	COG1063	alcohol dehydrogenase
MyAD_00145	COG0287	Prephenate dehydrogenase
MyAD_00155	COG1174	glycine betaine transport
MyAD_00175	COG5416	Lipopolysaccharide assembly protein A domain
MyAD_00190	COG2015	COG2015, Alkyl sulfatase and related hydrolases
MyAD_00220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MyAD_00295	COG1216	Glycosyl transferase, family 2
MyAD_00315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MyAD_00320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MyAD_00335	COG0277	FAD linked oxidase domain protein
MyAD_00340	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_00360	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MyAD_00395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MyAD_00405	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_00425	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MyAD_00435	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MyAD_00440	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MyAD_00445	COG0671	phosphoesterase, PA-phosphatase related
MyAD_00450	COG1216	Glycosyl transferase, family 2
MyAD_00470	COG0561	phosphatase activity
MyAD_00475	COG0204	Acyl-transferase
MyAD_00480	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MyAD_00480	COG2146	nitrite reductase [NAD(P)H] activity
MyAD_00500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MyAD_00535	COG1316	TRANSCRIPTIONal
MyAD_00540	COG1528	Iron-storage protein
MyAD_00555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MyAD_00605	COG0789	Transcriptional regulator
MyAD_00610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MyAD_00615	COG2072	flavoprotein involved in K transport
MyAD_00620	COG1309	transcriptional regulator
MyAD_00625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MyAD_00630	COG1796	DNA polymerase
MyAD_00630	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MyAD_00645	COG0069	glutamate synthase activity
MyAD_00645	COG0067	glutamate synthase
MyAD_00645	COG0070	glutamate synthase
MyAD_00655	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MyAD_00660	COG0783	Belongs to the Dps family
MyAD_00680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MyAD_00695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MyAD_00710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MyAD_00740	COG2226	methyltransferase
MyAD_00745	COG0438	transferase activity, transferring glycosyl groups
MyAD_00770	COG1335	isochorismatase
MyAD_00775	COG0789	Transcriptional regulator
MyAD_00780	COG0659	secondary active sulfate transmembrane transporter activity
MyAD_00795	COG0842	Transport permease protein
MyAD_00810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MyAD_00815	COG3842	ATPase activity
MyAD_00840	COG1022	Amp-dependent synthetase and ligase
MyAD_00840	COG3320	Male sterility
MyAD_00910	COG4044	May play a role in the intracellular transport of hydrophobic ligands
MyAD_00925	COG1116	anion transmembrane transporter activity
MyAD_00945	COG3961	Belongs to the TPP enzyme family
MyAD_00955	COG1960	acyl-CoA dehydrogenase activity
MyAD_00960	COG1960	acyl-CoA dehydrogenase activity
MyAD_00965	COG2132	Multicopper oxidase
MyAD_00970	COG2197	response regulator
MyAD_01005	COG1643	Atp-dependent helicase
MyAD_01025	COG3384	dioxygenase
MyAD_01040	COG1063	alcohol dehydrogenase
MyAD_01060	COG2409	Drug exporters of the RND superfamily
MyAD_01060	COG1033	growth of symbiont in host cell
MyAD_01070	COG1309	transcriptional regulator
MyAD_01080	COG3263	regulation of cellular component size
MyAD_01130	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_01160	COG0714	Associated with various cellular activities
MyAD_01190	COG2197	response regulator
MyAD_01195	COG0778	Nitroreductase
MyAD_01225	COG0702	epimerase
MyAD_01240	COG1403	HNH endonuclease
MyAD_01245	COG1595	DNA-templated transcription, initiation
MyAD_01255	COG0488	(ABC) transporter
MyAD_01265	COG2030	dehydratase
MyAD_01270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MyAD_01290	COG0477	Major facilitator Superfamily
MyAD_01320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MyAD_01340	COG3011	Protein conserved in bacteria
MyAD_01345	COG0187	DNA topoisomerase II activity
MyAD_01350	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MyAD_01380	COG2409	Drug exporters of the RND superfamily
MyAD_01400	COG3590	peptidase
MyAD_01405	COG1376	ErfK ybiS ycfS ynhG family protein
MyAD_01420	COG1937	Protein conserved in bacteria
MyAD_01465	COG2267	carboxylic ester hydrolase activity
MyAD_01490	COG3119	arylsulfatase activity
MyAD_01540	COG0300	oxidoreductase activity
MyAD_01545	COG3619	membrane
MyAD_01575	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MyAD_01600	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MyAD_01605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MyAD_01615	COG1802	Transcriptional regulator
MyAD_01635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MyAD_01645	COG1960	acyl-CoA dehydrogenase activity
MyAD_01665	COG1309	transcriptional regulator
MyAD_01675	COG4521	taurine ABC transporter
MyAD_01680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MyAD_01695	COG0598	Magnesium transport protein CorA
MyAD_01700	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MyAD_01705	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MyAD_01715	COG1960	acyl-CoA dehydrogenase activity
MyAD_01725	COG0583	DNA-binding transcription factor activity
MyAD_01735	COG1960	acyl-CoA dehydrogenase activity
MyAD_01760	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_01765	COG1012	belongs to the aldehyde dehydrogenase family
MyAD_01770	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MyAD_01775	COG1309	transcriptional regulator
MyAD_01785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MyAD_01790	COG1349	DNA-binding transcription factor activity
MyAD_01795	COG1105	Belongs to the carbohydrate kinase PfkB family
MyAD_01800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MyAD_01800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MyAD_01810	COG1404	Belongs to the peptidase S8 family
MyAD_01840	COG4842	Belongs to the WXG100 family
MyAD_01845	COG4842	Belongs to the WXG100 family
MyAD_01860	COG1674	ftsk spoiiie
MyAD_01875	COG0464	growth
MyAD_01895	COG1716	ATPase activity
MyAD_01925	COG2354	Protein conserved in bacteria
MyAD_01930	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MyAD_01940	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MyAD_01995	COG1716	ATPase activity
MyAD_02000	COG1716	ATPase activity
MyAD_02015	COG0768	penicillin binding
MyAD_02025	COG0515	serine threonine protein kinase
MyAD_02025	COG2815	serine threonine protein kinase
MyAD_02030	COG2272	Belongs to the type-B carboxylesterase lipase family
MyAD_02090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MyAD_02095	COG0187	DNA topoisomerase II activity
MyAD_02100	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
MyAD_02105	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MyAD_02110	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MyAD_02115	COG0592	DNA-directed DNA polymerase activity
MyAD_02125	COG0594	ribonuclease P activity
MyAD_02130	COG0706	membrane insertase activity
MyAD_02140	COG0357	Ribosomal RNA small subunit methyltransferase G
MyAD_02145	COG1192	Involved in chromosome partitioning
MyAD_02160	COG3409	Peptidoglycan-binding domain 1 protein
MyAD_02160	COG0860	N-Acetylmuramoyl-L-alanine amidase
MyAD_02180	COG1595	DNA-templated transcription, initiation
MyAD_02200	COG0617	tRNA 3'-terminal CCA addition
MyAD_02220	COG2814	Major facilitator Superfamily
MyAD_02225	COG1678	Uncharacterized ACR, COG1678
MyAD_02240	COG0495	leucyl-tRNA aminoacylation
MyAD_02245	COG1063	alcohol dehydrogenase
MyAD_02250	COG0300	oxidoreductase activity
MyAD_02265	COG1126	abc transporter atp-binding protein
MyAD_02270	COG0765	amino acid transport
MyAD_02275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MyAD_02290	COG1260	myo-inositol-1-phosphate synthase
MyAD_02315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MyAD_02325	COG0360	Binds together with S18 to 16S ribosomal RNA
MyAD_02330	COG0629	single-stranded DNA binding
MyAD_02335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MyAD_02340	COG0359	binds to the 23S rRNA
MyAD_02375	COG3135	benzoate transporter
MyAD_02380	COG1396	sequence-specific DNA binding
MyAD_02400	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_02405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MyAD_02415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MyAD_02420	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_02460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MyAD_02475	COG0601	transmembrane transport
MyAD_02495	COG0363	glucosamine-6-phosphate deaminase activity
MyAD_02515	COG0477	Major facilitator Superfamily
MyAD_02555	COG0596	Alpha beta hydrolase
MyAD_02600	COG2072	flavoprotein involved in K transport
MyAD_02615	COG1285	pathogenesis
MyAD_02640	COG1072	(Pantothenic acid kinase))
MyAD_02645	COG1609	Transcriptional regulator
MyAD_02660	COG0644	oxidoreductase
MyAD_02670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MyAD_02675	COG2301	Belongs to the HpcH HpaI aldolase family
MyAD_02680	COG3757	hydrolase, family 25
MyAD_02685	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MyAD_02720	COG2409	Drug exporters of the RND superfamily
MyAD_02730	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MyAD_02745	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MyAD_02755	COG0702	epimerase
MyAD_02765	COG4221	oxidoreductase activity
MyAD_02775	COG0640	Transcriptional regulator
MyAD_02790	COG1960	acyl-CoA dehydrogenase activity
MyAD_02815	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_02835	COG1960	acyl-CoA dehydrogenase activity
MyAD_02850	COG1960	acyl-CoA dehydrogenase activity
MyAD_02930	COG4981	capsule polysaccharide biosynthetic process
MyAD_02935	COG1472	Belongs to the glycosyl hydrolase 3 family
MyAD_02950	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_02955	COG0183	Belongs to the thiolase family
MyAD_02965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MyAD_02970	COG1396	sequence-specific DNA binding
MyAD_02975	COG0740	serine-type endopeptidase activity
MyAD_02980	COG0740	serine-type endopeptidase activity
MyAD_02985	COG1960	acyl-CoA dehydrogenase activity
MyAD_03010	COG5651	PPE family
MyAD_03020	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_03025	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MyAD_03035	COG1053	succinate dehydrogenase
MyAD_03060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MyAD_03060	COG2146	nitrite reductase [NAD(P)H] activity
MyAD_03085	COG1984	allophanate hydrolase subunit 2
MyAD_03090	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MyAD_03110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MyAD_03115	COG2957	Belongs to the agmatine deiminase family
MyAD_03120	COG1764	response to oxidative stress
MyAD_03125	COG1846	Transcriptional regulator
MyAD_03130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MyAD_03135	COG1063	alcohol dehydrogenase
MyAD_03145	COG1309	transcriptional regulator
MyAD_03195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MyAD_03250	COG1012	belongs to the aldehyde dehydrogenase family
MyAD_03250	COG1454	alcohol dehydrogenase
MyAD_03270	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
MyAD_03300	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MyAD_03325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MyAD_03330	COG1012	belongs to the aldehyde dehydrogenase family
MyAD_03350	COG0477	Major facilitator Superfamily
MyAD_03365	COG0803	Belongs to the bacterial solute-binding protein 9 family
MyAD_03370	COG1121	(ABC) transporter
MyAD_03375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MyAD_03385	COG0596	Alpha beta hydrolase
MyAD_03395	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MyAD_03415	COG0583	DNA-binding transcription factor activity
MyAD_03430	COG3958	Transketolase
MyAD_03435	COG3959	Transketolase, thiamine diphosphate binding domain
MyAD_03450	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_03455	COG2376	Dihydroxyacetone kinase
MyAD_03460	COG0698	ribose 5-phosphate isomerase
MyAD_03470	COG0352	thiamine-phosphate diphosphorylase activity
MyAD_03470	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MyAD_03470	COG0351	phosphomethylpyrimidine kinase
MyAD_03475	COG0693	protein deglycase activity
MyAD_03480	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_03560	COG1129	ABC transporter
MyAD_03565	COG1172	Belongs to the binding-protein-dependent transport system permease family
MyAD_03570	COG3467	pyridoxamine 5'-phosphate
MyAD_03590	COG2144	transferase activity, transferring acyl groups
MyAD_03600	COG2072	flavoprotein involved in K transport
MyAD_03610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MyAD_03630	COG1309	transcriptional regulator
MyAD_03650	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_03655	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_03660	COG1960	acyl-CoA dehydrogenase activity
MyAD_03680	COG0346	lactoylglutathione lyase activity
MyAD_03695	COG0464	growth
MyAD_03700	COG3266	domain, Protein
MyAD_03705	COG1674	ftsk spoiiie
MyAD_03725	COG4842	Belongs to the WXG100 family
MyAD_03740	COG1404	Belongs to the peptidase S8 family
MyAD_03760	COG4106	trans-aconitate 2-methyltransferase activity
MyAD_03775	COG4424	Sulfotransferase
MyAD_03780	COG3119	arylsulfatase activity
MyAD_03785	COG0494	nUDIX hydrolase
MyAD_03800	COG0671	phosphoesterase, PA-phosphatase related
MyAD_03825	COG1396	sequence-specific DNA binding
MyAD_03825	COG3800	Transcriptional regulator
MyAD_03835	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MyAD_03845	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MyAD_03910	COG0243	molybdopterin cofactor binding
MyAD_03930	COG1522	sequence-specific DNA binding
MyAD_03960	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MyAD_03965	COG3387	PFAM Glycoside hydrolase 15-related
MyAD_03980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MyAD_03990	COG0604	alcohol dehydrogenase
MyAD_03995	COG0747	negative chemotaxis
MyAD_04005	COG0601	transmembrane transport
MyAD_04010	COG0444	Belongs to the ABC transporter superfamily
MyAD_04015	COG4608	Belongs to the ABC transporter superfamily
MyAD_04045	COG3550	peptidyl-serine autophosphorylation
MyAD_04190	COG0717	Belongs to the dCTP deaminase family
MyAD_04200	COG2267	carboxylic ester hydrolase activity
MyAD_04245	COG0247	lactate metabolic process
MyAD_04245	COG2181	nitrate reductase activity
MyAD_04305	COG4399	Belongs to the UPF0754 family
MyAD_04320	COG0443	Heat shock 70 kDa protein
MyAD_04325	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MyAD_04330	COG0484	heat shock protein binding
MyAD_04335	COG0789	Transcriptional regulator
MyAD_04415	COG0542	response to heat
MyAD_04450	COG0477	Major facilitator Superfamily
MyAD_04455	COG1309	transcriptional regulator
MyAD_04460	COG0586	Pfam SNARE associated Golgi protein
MyAD_04490	COG1994	Peptidase M50
MyAD_04500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MyAD_04530	COG2124	cytochrome p450
MyAD_04535	COG0596	Alpha beta hydrolase
MyAD_04540	COG2409	Drug exporters of the RND superfamily
MyAD_04550	COG0025	NhaP-type Na H and K H
MyAD_04585	COG0583	DNA-binding transcription factor activity
MyAD_04595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MyAD_04600	COG4221	oxidoreductase activity
MyAD_04610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MyAD_04625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MyAD_04630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MyAD_04635	COG2188	Transcriptional regulator
MyAD_04655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MyAD_04665	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MyAD_04670	COG0515	serine threonine protein kinase
MyAD_04675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MyAD_04690	COG0352	thiamine-phosphate diphosphorylase activity
MyAD_04695	COG2022	thiamine diphosphate biosynthetic process
MyAD_04695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MyAD_04705	COG2022	thiamine diphosphate biosynthetic process
MyAD_04720	COG2234	aminopeptidase activity
MyAD_04725	COG2234	aminopeptidase activity
MyAD_04730	COG2409	Drug exporters of the RND superfamily
MyAD_04740	COG1755	Isoprenylcysteine carboxyl methyltransferase
MyAD_04750	COG2233	PERMEase
MyAD_04755	COG1012	belongs to the aldehyde dehydrogenase family
MyAD_04760	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_04780	COG2072	flavoprotein involved in K transport
MyAD_04795	COG0351	phosphomethylpyrimidine kinase
MyAD_04800	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MyAD_04870	COG2226	methyltransferase
MyAD_04890	COG0542	response to heat
MyAD_04905	COG0242	peptide deformylase activity
MyAD_04920	COG2032	superoxide dismutase activity
MyAD_04940	COG1320	monovalent cation:proton antiporter activity
MyAD_04945	COG2212	antiporter activity
MyAD_04960	COG1006	Multisubunit Na H antiporter MnhC subunit
MyAD_04965	COG2111	Na H antiporter
MyAD_04965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MyAD_04970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MyAD_04990	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_04995	COG1024	Enoyl-CoA hydratase
MyAD_05000	COG1960	acyl-CoA dehydrogenase activity
MyAD_05005	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_05040	COG0647	UMP catabolic process
MyAD_05055	COG4221	oxidoreductase activity
MyAD_05065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MyAD_05070	COG1116	anion transmembrane transporter activity
MyAD_05075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MyAD_05080	COG0459	protein refolding
MyAD_05095	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MyAD_05110	COG1012	belongs to the aldehyde dehydrogenase family
MyAD_05115	COG2326	polyphosphate kinase activity
MyAD_05140	COG1505	serine-type exopeptidase activity
MyAD_05150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MyAD_05155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MyAD_05170	COG3706	GGDEF domain
MyAD_05200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MyAD_05205	COG2326	polyphosphate kinase activity
MyAD_05215	COG2733	membrane
MyAD_05280	COG0438	transferase activity, transferring glycosyl groups
MyAD_05290	COG0588	phosphoglycerate mutase activity
MyAD_05295	COG5002	protein histidine kinase activity
MyAD_05300	COG0745	RESPONSE REGULATOR receiver
MyAD_05360	COG0560	Phosphoserine phosphatase
MyAD_05375	COG0181	hydroxymethylbilane synthase activity
MyAD_05380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MyAD_05440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MyAD_05445	COG0406	alpha-ribazole phosphatase activity
MyAD_05455	COG0785	Cytochrome C biogenesis protein
MyAD_05470	COG2894	cell division
MyAD_05505	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MyAD_05510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MyAD_05545	COG2070	2-Nitropropane dioxygenase
MyAD_05565	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MyAD_05635	COG1309	transcriptional regulator
MyAD_05650	COG0531	amino acid
MyAD_05655	COG0300	oxidoreductase activity
MyAD_05660	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_05680	COG4221	oxidoreductase activity
MyAD_05690	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MyAD_05710	COG4552	Acetyltransferase involved in intracellular survival and related
MyAD_05725	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_05735	COG1228	amidohydrolase
MyAD_05740	COG4948	Mandelate Racemase Muconate Lactonizing
MyAD_05750	COG4977	sequence-specific DNA binding
MyAD_05765	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MyAD_05780	COG0438	transferase activity, transferring glycosyl groups
MyAD_05835	COG1100	Small GTP-binding protein
MyAD_05870	COG4221	oxidoreductase activity
MyAD_05875	COG2226	methyltransferase
MyAD_05880	COG0523	cobalamin synthesis protein
MyAD_05900	COG0235	Class ii aldolase
MyAD_05905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MyAD_05910	COG3123	guanosine phosphorylase activity
MyAD_05915	COG1309	transcriptional regulator
MyAD_05920	COG0644	oxidoreductase
MyAD_05930	COG0501	Belongs to the peptidase M48B family
MyAD_05950	COG1666	GTP binding
MyAD_05980	COG3706	GGDEF domain
MyAD_06030	COG0438	transferase activity, transferring glycosyl groups
MyAD_06045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MyAD_06050	COG1074	ATP-dependent DNA helicase activity
MyAD_06055	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MyAD_06070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MyAD_06095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MyAD_06100	COG1959	2 iron, 2 sulfur cluster binding
MyAD_06125	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MyAD_06135	COG2030	dehydratase
MyAD_06150	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MyAD_06160	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MyAD_06165	COG0081	regulation of translation
MyAD_06175	COG1088	dTDP-glucose 4,6-dehydratase activity
MyAD_06220	COG0489	protein tyrosine kinase activity
MyAD_06240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MyAD_06245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MyAD_06305	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MyAD_06310	COG0222	ribosome binding
MyAD_06320	COG0085	RNA polymerase activity
MyAD_06325	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MyAD_06350	COG1960	acyl-CoA dehydrogenase activity
MyAD_06400	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MyAD_06405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MyAD_06430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MyAD_06435	COG1834	amidinotransferase
MyAD_06440	COG1522	sequence-specific DNA binding
MyAD_06465	COG0535	radical SAM domain protein
MyAD_06495	COG0477	Major facilitator Superfamily
MyAD_06510	COG2272	Belongs to the type-B carboxylesterase lipase family
MyAD_06525	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MyAD_06530	COG0088	Forms part of the polypeptide exit tunnel
MyAD_06540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MyAD_06545	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MyAD_06550	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MyAD_06560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MyAD_06570	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MyAD_06610	COG3619	membrane
MyAD_06615	COG3069	C4-dicarboxylate transmembrane transporter activity
MyAD_06650	COG1012	belongs to the aldehyde dehydrogenase family
MyAD_06660	COG0405	Gamma-glutamyltransferase
MyAD_06675	COG0154	amidase activity
MyAD_06680	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MyAD_06695	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MyAD_06705	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MyAD_06710	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MyAD_06715	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MyAD_06720	COG1841	ribosomal large subunit assembly
MyAD_06725	COG0200	Binds to the 23S rRNA
MyAD_06730	COG0616	signal peptide processing
MyAD_06735	COG2197	response regulator
MyAD_06745	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MyAD_06760	COG1366	Belongs to the anti-sigma-factor antagonist family
MyAD_06765	COG0477	Major facilitator Superfamily
MyAD_06770	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MyAD_06775	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MyAD_06805	COG0563	adenylate kinase activity
MyAD_06835	COG2197	response regulator
MyAD_06860	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
MyAD_06865	COG1088	dTDP-glucose 4,6-dehydratase activity
MyAD_06880	COG3852	Histidine kinase
MyAD_06885	COG0492	ferredoxin-NADP+ reductase activity
MyAD_06915	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MyAD_06920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MyAD_06925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MyAD_06930	COG0202	RNA polymerase activity
MyAD_06935	COG0203	ribosomal protein L17
MyAD_06965	COG5006	permease, DMT superfamily
MyAD_06975	COG3268	Saccharopine dehydrogenase
MyAD_07005	COG0142	geranyltranstransferase activity
MyAD_07015	COG1404	Belongs to the peptidase S8 family
MyAD_07055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MyAD_07065	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MyAD_07080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MyAD_07125	COG0531	amino acid
MyAD_07130	COG4303	Ethanolamine ammonia lyase large subunit
MyAD_07145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MyAD_07150	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MyAD_07175	COG0513	Belongs to the DEAD box helicase family
MyAD_07180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MyAD_07190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MyAD_07205	COG2814	Major facilitator Superfamily
MyAD_07215	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
MyAD_07230	COG1349	DNA-binding transcription factor activity
MyAD_07235	COG2213	PTS system mannitol-specific
MyAD_07235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MyAD_07240	COG1063	alcohol dehydrogenase
MyAD_07255	COG0076	glutamate decarboxylase activity
MyAD_07260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MyAD_07280	COG0456	acetyltransferase
MyAD_07285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MyAD_07300	COG1113	amino acid transport
MyAD_07320	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MyAD_07375	COG0516	GMP reductase activity
MyAD_07400	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MyAD_07405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MyAD_07405	COG0519	Catalyzes the synthesis of GMP from XMP
MyAD_07455	COG4221	oxidoreductase activity
MyAD_07460	COG1280	lysine exporter protein (LysE YggA)
MyAD_07475	COG0789	Transcriptional regulator
MyAD_07485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MyAD_07490	COG1120	ATPase activity
MyAD_07510	COG0753	catalase activity
MyAD_07530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MyAD_07530	COG0493	'glutamate synthase
MyAD_07535	COG4689	acetoacetate decarboxylase
MyAD_07540	COG1960	acyl-CoA dehydrogenase activity
MyAD_07550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MyAD_07560	COG0179	Fumarylacetoacetate (FAA) hydrolase
MyAD_07570	COG0730	response to heat
MyAD_07595	COG1937	Protein conserved in bacteria
MyAD_07645	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MyAD_07660	COG2018	Roadblock/LC7 domain
MyAD_07675	COG1357	PFAM Pentapeptide repeats (8 copies)
MyAD_07680	COG1131	(ABC) transporter
MyAD_07680	COG1716	ATPase activity
MyAD_07680	COG0842	Transport permease protein
MyAD_07685	COG1902	pentaerythritol trinitrate reductase activity
MyAD_07685	COG0446	pyridine nucleotide-disulphide oxidoreductase
MyAD_07710	COG2873	o-acetylhomoserine
MyAD_07725	COG0708	Exodeoxyribonuclease III
MyAD_07740	COG1295	ribonuclease BN
MyAD_07745	COG2076	Multidrug Resistance protein
MyAD_07750	COG2070	2-Nitropropane dioxygenase
MyAD_07755	COG1686	Belongs to the peptidase S11 family
MyAD_07760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MyAD_07785	COG1595	DNA-templated transcription, initiation
MyAD_07805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MyAD_07820	COG2009	succinate dehydrogenase
MyAD_07860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MyAD_07870	COG3180	Ammonia monooxygenase
MyAD_07895	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MyAD_07895	COG1473	amidohydrolase
MyAD_07915	COG0564	pseudouridine synthase activity
MyAD_07925	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_07935	COG1309	transcriptional regulator
MyAD_07955	COG1201	RNA secondary structure unwinding
MyAD_07975	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_07990	COG1012	belongs to the aldehyde dehydrogenase family
MyAD_08000	COG1522	sequence-specific DNA binding
MyAD_08020	COG0640	Transcriptional regulator
MyAD_08045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MyAD_08085	COG4770	biotin carboxylase activity
MyAD_08120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MyAD_08125	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_08135	COG0438	transferase activity, transferring glycosyl groups
MyAD_08195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MyAD_08245	COG1316	TRANSCRIPTIONal
MyAD_08275	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MyAD_08275	COG0778	Nitroreductase
MyAD_08300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MyAD_08310	COG1482	cell wall glycoprotein biosynthetic process
MyAD_08315	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MyAD_08340	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MyAD_08360	COG0745	RESPONSE REGULATOR receiver
MyAD_08365	COG5002	protein histidine kinase activity
MyAD_08370	COG5401	PFAM Sporulation and spore germination
MyAD_08380	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MyAD_08400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MyAD_08420	COG1162	GTPase activity
MyAD_08425	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MyAD_08430	COG2135	peptidase activity
MyAD_08440	COG2226	methyltransferase
MyAD_08450	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MyAD_08455	COG1595	DNA-templated transcription, initiation
MyAD_08460	COG5662	AntiSigma factor
MyAD_08480	COG1597	lipid kinase activity
MyAD_08490	COG3012	SEC-C Motif Domain Protein
MyAD_08495	COG0583	DNA-binding transcription factor activity
MyAD_08500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MyAD_08505	COG1960	acyl-CoA dehydrogenase activity
MyAD_08510	COG1960	acyl-CoA dehydrogenase activity
MyAD_08515	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MyAD_08535	COG0406	alpha-ribazole phosphatase activity
MyAD_08550	COG0513	Belongs to the DEAD box helicase family
MyAD_08595	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MyAD_08600	COG0596	Alpha beta hydrolase
MyAD_08620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MyAD_08630	COG0183	Belongs to the thiolase family
MyAD_08645	COG1414	Transcriptional regulator
MyAD_08660	COG0145	ligase activity
MyAD_08670	COG0145	ligase activity
MyAD_08695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MyAD_08710	COG3480	Lon protease (S16) C-terminal proteolytic domain
MyAD_08715	COG1615	UPF0182 protein
MyAD_08750	COG0582	viral genome integration into host DNA
MyAD_08835	COG1074	ATP-dependent DNA helicase activity
MyAD_08840	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MyAD_08845	COG1316	TRANSCRIPTIONal
MyAD_08850	COG0346	lactoylglutathione lyase activity
MyAD_08890	COG0583	DNA-binding transcription factor activity
MyAD_08915	COG1454	alcohol dehydrogenase
MyAD_08945	COG5001	Diguanylate cyclase
MyAD_08960	COG1408	metallophosphoesterase
MyAD_09005	COG2770	Histidine kinase
MyAD_09005	COG2208	phosphoserine phosphatase activity
MyAD_09040	COG1295	ribonuclease BN
MyAD_09050	COG4221	oxidoreductase activity
MyAD_09055	COG3622	Belongs to the hyi family
MyAD_09060	COG1408	metallophosphoesterase
MyAD_09070	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_09090	COG3158	transport of potassium into the cell
MyAD_09120	COG1309	transcriptional regulator
MyAD_09260	COG0713	ATP synthesis coupled electron transport
MyAD_09270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MyAD_09275	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MyAD_09280	COG1034	ATP synthesis coupled electron transport
MyAD_09300	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MyAD_09305	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MyAD_09355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MyAD_09360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MyAD_09380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MyAD_09385	COG1960	acyl-CoA dehydrogenase activity
MyAD_09395	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MyAD_09400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MyAD_09405	COG1960	acyl-CoA dehydrogenase activity
MyAD_09415	COG0483	inositol monophosphate 1-phosphatase activity
MyAD_09435	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MyAD_09440	COG0668	transmembrane transport
MyAD_09450	COG2884	Cell division ATP-binding protein ftsE
MyAD_09455	COG2177	Part of the ABC transporter FtsEX involved in
MyAD_09460	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MyAD_09480	COG1793	dna ligase
MyAD_09480	COG3285	dna ligase
MyAD_09495	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_09525	COG1309	transcriptional regulator
MyAD_09555	COG0270	DNA (cytosine-5-)-methyltransferase activity
MyAD_09565	COG0210	DNA helicase
MyAD_09585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MyAD_09600	COG1201	RNA secondary structure unwinding
MyAD_09640	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MyAD_09645	COG0668	transmembrane transport
MyAD_09650	COG3654	unkown
MyAD_09660	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MyAD_09690	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MyAD_09695	COG1605	Chorismate mutase
MyAD_09700	COG2190	(PTS) system
MyAD_09700	COG1263	PTS System
MyAD_09700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MyAD_09705	COG2190	(PTS) system
MyAD_09710	COG0363	glucosamine-6-phosphate deaminase activity
MyAD_09715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MyAD_09750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MyAD_09755	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MyAD_09775	COG0477	Major facilitator Superfamily
MyAD_09790	COG1309	transcriptional regulator
MyAD_09825	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MyAD_09830	COG3486	L-lysine 6-monooxygenase (NADPH) activity
MyAD_09835	COG1132	(ABC) transporter
MyAD_09840	COG1132	(ABC) transporter
MyAD_09865	COG1960	acyl-CoA dehydrogenase activity
MyAD_09870	COG1960	acyl-CoA dehydrogenase activity
MyAD_09900	COG1960	acyl-CoA dehydrogenase activity
MyAD_09910	COG0183	Belongs to the thiolase family
MyAD_09915	COG1960	acyl-CoA dehydrogenase activity
MyAD_09920	COG1802	Transcriptional regulator
MyAD_09930	COG1966	Carbon starvation protein
MyAD_09985	COG0067	glutamate synthase
MyAD_09985	COG0070	glutamate synthase
MyAD_09985	COG0069	glutamate synthase activity
MyAD_09990	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MyAD_10015	COG0431	NADPH-dependent FMN reductase
MyAD_10025	COG1780	Probably involved in ribonucleotide reductase function
MyAD_10030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MyAD_10055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MyAD_10095	COG1309	transcriptional regulator
MyAD_10100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MyAD_10120	COG2197	response regulator
MyAD_10130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MyAD_10135	COG2080	2 iron, 2 sulfur cluster binding
MyAD_10140	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MyAD_10160	COG1064	alcohol dehydrogenase
MyAD_10180	COG0560	Phosphoserine phosphatase
MyAD_10180	COG3830	Belongs to the UPF0237 family
MyAD_10185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MyAD_10195	COG2364	Membrane
MyAD_10200	COG1119	ATPase activity
MyAD_10230	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MyAD_10235	COG0110	maltose O-acetyltransferase activity
MyAD_10255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MyAD_10265	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MyAD_10285	COG0482	sulfurtransferase activity
MyAD_10295	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_10300	COG0596	Alpha beta hydrolase
MyAD_10320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MyAD_10330	COG3766	membrane
MyAD_10355	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MyAD_10360	COG0154	amidase activity
MyAD_10365	COG0028	Belongs to the TPP enzyme family
MyAD_10375	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MyAD_10400	COG0440	acetolactate synthase activity
MyAD_10430	COG0473	3-isopropylmalate dehydrogenase activity
MyAD_10440	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MyAD_10445	COG0450	alkyl hydroperoxide reductase
MyAD_10450	COG2271	Major facilitator Superfamily
MyAD_10455	COG0179	Fumarylacetoacetate (FAA) hydrolase
MyAD_10460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MyAD_10490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MyAD_10510	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MyAD_10525	COG0626	cystathionine gamma-synthase activity
MyAD_10530	COG1181	Belongs to the D-alanine--D-alanine ligase family
MyAD_10550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MyAD_10555	COG1461	Dihydroxyacetone kinase
MyAD_10570	COG2119	membrane
MyAD_10580	COG1366	Belongs to the anti-sigma-factor antagonist family
MyAD_10585	COG1215	transferase activity, transferring glycosyl groups
MyAD_10590	COG2208	phosphoserine phosphatase activity
MyAD_10645	COG0656	L-ascorbic acid biosynthetic process
MyAD_10650	COG0656	L-ascorbic acid biosynthetic process
MyAD_10670	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MyAD_10675	COG0742	ribosomal rna small subunit methyltransferase
MyAD_10680	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MyAD_10700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MyAD_10710	COG0571	ribonuclease III activity
MyAD_10715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MyAD_10735	COG1196	nuclear chromosome segregation
MyAD_10760	COG1845	cytochrome c oxidase, subunit III
MyAD_10770	COG1304	FMN binding
MyAD_10790	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MyAD_10795	COG3383	formate dehydrogenase (NAD+) activity
MyAD_10800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MyAD_10810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MyAD_10815	COG1686	Belongs to the peptidase S11 family
MyAD_10820	COG1686	Belongs to the peptidase S11 family
MyAD_10825	COG0367	asparagine synthase
MyAD_10835	COG1363	Peptidase, m42
MyAD_10900	COG0412	Dienelactone hydrolase
MyAD_10910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MyAD_10915	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_10920	COG3842	ATPase activity
MyAD_10970	COG0606	chelatase, subunit chli
MyAD_10990	COG4974	Belongs to the 'phage' integrase family
MyAD_11000	COG0052	Belongs to the universal ribosomal protein uS2 family
MyAD_11005	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MyAD_11010	COG0154	amidase activity
MyAD_11025	COG0528	UMP kinase activity
MyAD_11040	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MyAD_11060	COG0531	amino acid
MyAD_11080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MyAD_11085	COG0750	zinc metalloprotease
MyAD_11095	COG0456	acetyltransferase
MyAD_11100	COG0768	penicillin binding
MyAD_11135	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MyAD_11140	COG1012	belongs to the aldehyde dehydrogenase family
MyAD_11145	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_11150	COG2186	Transcriptional regulator
MyAD_11160	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
MyAD_11200	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MyAD_11200	COG1648	precorrin-2 dehydrogenase activity
MyAD_11215	COG0442	prolyl-tRNA aminoacylation
MyAD_11230	COG0779	Required for maturation of 30S ribosomal subunits
MyAD_11240	COG0481	GTPase activity
MyAD_11240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MyAD_11250	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MyAD_11265	COG1116	anion transmembrane transporter activity
MyAD_11275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MyAD_11280	COG1609	Transcriptional regulator
MyAD_11285	COG0673	inositol 2-dehydrogenase activity
MyAD_11300	COG1929	Belongs to the glycerate kinase type-1 family
MyAD_11305	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MyAD_11310	COG1172	Belongs to the binding-protein-dependent transport system permease family
MyAD_11320	COG2390	Transcriptional regulator
MyAD_11325	COG1069	ribulokinase activity
MyAD_11330	COG1063	alcohol dehydrogenase
MyAD_11335	COG1879	ABC-type sugar transport system periplasmic component
MyAD_11340	COG1024	Enoyl-CoA hydratase
MyAD_11395	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MyAD_11405	COG1185	polyribonucleotide nucleotidyltransferase activity
MyAD_11410	COG0612	Peptidase, M16
MyAD_11420	COG0686	Belongs to the AlaDH PNT family
MyAD_11425	COG1522	sequence-specific DNA binding
MyAD_11445	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MyAD_11470	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MyAD_11480	COG3214	Protein conserved in bacteria
MyAD_11485	COG3300	MHYT domain
MyAD_11485	COG5001	Diguanylate cyclase
MyAD_11490	COG4221	oxidoreductase activity
MyAD_11520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MyAD_11525	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MyAD_11530	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MyAD_11545	COG0659	secondary active sulfate transmembrane transporter activity
MyAD_11550	COG1674	ftsk spoiiie
MyAD_11555	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MyAD_11565	COG1396	sequence-specific DNA binding
MyAD_11585	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
MyAD_11605	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MyAD_11610	COG2137	regulation of response to DNA damage stimulus
MyAD_11625	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_11635	COG2814	Major facilitator Superfamily
MyAD_11640	COG0765	amino acid transport
MyAD_11645	COG0765	amino acid transport
MyAD_11650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MyAD_11655	COG1126	abc transporter atp-binding protein
MyAD_11660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MyAD_11670	COG1196	nuclear chromosome segregation
MyAD_11675	COG0697	spore germination
MyAD_11685	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MyAD_11695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MyAD_11715	COG1960	acyl-CoA dehydrogenase activity
MyAD_11730	COG1960	acyl-CoA dehydrogenase activity
MyAD_11740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MyAD_11745	COG1764	response to oxidative stress
MyAD_11750	COG1846	Transcriptional regulator
MyAD_11760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MyAD_11835	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_11850	COG0483	inositol monophosphate 1-phosphatase activity
MyAD_11870	COG0756	dUTP diphosphatase activity
MyAD_11900	COG0569	domain protein
MyAD_11905	COG0531	amino acid
MyAD_11910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MyAD_11935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MyAD_11940	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MyAD_11960	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MyAD_11980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MyAD_11995	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MyAD_11995	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MyAD_12040	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MyAD_12095	COG2801	Transposase and inactivated derivatives
MyAD_12155	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MyAD_12160	COG2267	carboxylic ester hydrolase activity
MyAD_12190	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MyAD_12195	COG0058	SHG alpha-glucan phosphorylase activity
MyAD_12205	COG4762	Protein conserved in bacteria
MyAD_12235	COG1560	Kdo2-lipid A biosynthetic process
MyAD_12240	COG0438	transferase activity, transferring glycosyl groups
MyAD_12250	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MyAD_12255	COG1946	Acyl-CoA thioesterase
MyAD_12265	COG1960	acyl-CoA dehydrogenase activity
MyAD_12270	COG0217	transcriptional regulatory protein
MyAD_12275	COG0702	epimerase
MyAD_12290	COG2255	four-way junction helicase activity
MyAD_12320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MyAD_12325	COG0747	negative chemotaxis
MyAD_12335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MyAD_12345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MyAD_12355	COG0124	histidyl-tRNA synthetase
MyAD_12360	COG1490	D-aminoacyl-tRNA deacylase activity
MyAD_12370	COG0411	ABC transporter
MyAD_12380	COG0559	Belongs to the binding-protein-dependent transport system permease family
MyAD_12385	COG0683	leucine binding
MyAD_12415	COG1309	transcriptional regulator
MyAD_12440	COG2272	Belongs to the type-B carboxylesterase lipase family
MyAD_12450	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MyAD_12460	COG0183	Belongs to the thiolase family
MyAD_12530	COG0432	Pfam Uncharacterised protein family UPF0047
MyAD_12535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MyAD_12540	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MyAD_12550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MyAD_12560	COG1929	Belongs to the glycerate kinase type-1 family
MyAD_12565	COG1609	Transcriptional regulator
MyAD_12600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MyAD_12610	COG0006	proline dipeptidase activity
MyAD_12615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MyAD_12620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MyAD_12630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MyAD_12650	COG2188	Transcriptional regulator
MyAD_12665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MyAD_12685	COG0477	Major facilitator Superfamily
MyAD_12690	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MyAD_12695	COG0540	Belongs to the ATCase OTCase family
MyAD_12710	COG0505	Belongs to the CarA family
MyAD_12715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MyAD_12720	COG0284	orotidine-5'-phosphate decarboxylase activity
MyAD_12735	COG1758	RNA polymerase activity
MyAD_12750	COG2072	flavoprotein involved in K transport
MyAD_12780	COG1704	LemA family
MyAD_12785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MyAD_12830	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
MyAD_12830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MyAD_12895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MyAD_12895	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MyAD_12900	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MyAD_12910	COG0456	acetyltransferase
MyAD_12910	COG3153	acetyltransferase
MyAD_12920	COG1365	unkown
MyAD_12925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MyAD_12930	COG0322	excinuclease ABC activity
MyAD_12935	COG1660	Displays ATPase and GTPase activities
MyAD_12950	COG1132	(ABC) transporter
MyAD_12955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MyAD_12960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MyAD_12965	COG0126	phosphoglycerate kinase activity
MyAD_12970	COG0149	triose-phosphate isomerase activity
MyAD_12980	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MyAD_13015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MyAD_13025	COG0109	protoheme IX farnesyltransferase activity
MyAD_13030	COG1301	dicarboxylic acid transport
MyAD_13055	COG3842	ATPase activity
MyAD_13060	COG3833	ABC-type maltose transport systems, permease component
MyAD_13075	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_13080	COG1070	Carbohydrate kinase
MyAD_13085	COG0434	BtpA family
MyAD_13090	COG0483	inositol monophosphate 1-phosphatase activity
MyAD_13095	COG1349	DNA-binding transcription factor activity
MyAD_13140	COG0396	ATPase activity
MyAD_13155	COG2151	metal-sulfur cluster biosynthetic enzyme
MyAD_13165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MyAD_13175	COG0488	(ABC) transporter
MyAD_13185	COG1309	transcriptional regulator
MyAD_13190	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MyAD_13200	COG3883	PFAM NLP P60 protein
MyAD_13200	COG0791	NLP P60 protein
MyAD_13210	COG0714	Associated with various cellular activities
MyAD_13220	COG2304	oxidoreductase activity
MyAD_13225	COG0667	Aldo Keto reductase
MyAD_13230	COG2207	Transcriptional regulator
MyAD_13240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MyAD_13295	COG3321	synthase
MyAD_13295	COG0604	alcohol dehydrogenase
MyAD_13295	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_13355	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MyAD_13360	COG2501	S4 domain
MyAD_13370	COG0252	asparaginase activity
MyAD_13395	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MyAD_13435	COG0789	Transcriptional regulator
MyAD_13475	COG0156	8-amino-7-oxononanoate synthase activity
MyAD_13490	COG1309	transcriptional regulator
MyAD_13535	COG1012	belongs to the aldehyde dehydrogenase family
MyAD_13540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MyAD_13545	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MyAD_13570	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MyAD_13600	COG3383	formate dehydrogenase (NAD+) activity
MyAD_13605	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_13615	COG2124	cytochrome p450
MyAD_13650	COG1280	lysine exporter protein (LysE YggA)
MyAD_13665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MyAD_13670	COG0131	Imidazoleglycerol-phosphate dehydratase
MyAD_13680	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MyAD_13685	COG0483	inositol monophosphate 1-phosphatase activity
MyAD_13695	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MyAD_13710	COG1119	ATPase activity
MyAD_13720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MyAD_13730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MyAD_13740	COG0134	indole-3-glycerol-phosphate synthase activity
MyAD_13750	COG0159	tryptophan synthase activity
MyAD_13775	COG0243	molybdopterin cofactor binding
MyAD_13795	COG0129	dihydroxy-acid dehydratase activity
MyAD_13810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MyAD_13820	COG0167	dihydroorotate dehydrogenase activity
MyAD_13840	COG1968	undecaprenyl-diphosphatase activity
MyAD_13845	COG0406	alpha-ribazole phosphatase activity
MyAD_13845	COG0328	RNA-DNA hybrid ribonuclease activity
MyAD_13865	COG0215	cysteine-tRNA ligase activity
MyAD_13870	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_13880	COG1410	methionine synthase
MyAD_13880	COG0646	methionine synthase
MyAD_13890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MyAD_13900	COG0477	Major facilitator Superfamily
MyAD_13905	COG0140	phosphoribosyl-ATP diphosphatase activity
MyAD_13910	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MyAD_13950	COG0640	Transcriptional regulator
MyAD_14010	COG2205	protein histidine kinase activity
MyAD_14015	COG0745	RESPONSE REGULATOR receiver
MyAD_14020	COG0456	acetyltransferase
MyAD_14025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MyAD_14030	COG1917	Cupin 2, conserved barrel domain protein
MyAD_14035	COG5285	phytanoyl-CoA dioxygenase
MyAD_14040	COG4122	O-methyltransferase activity
MyAD_14050	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MyAD_14055	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MyAD_14060	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MyAD_14070	COG2378	regulation of single-species biofilm formation
MyAD_14075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MyAD_14110	COG0300	oxidoreductase activity
MyAD_14195	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MyAD_14200	COG0463	Glycosyl transferase, family 2
MyAD_14220	COG2272	Belongs to the type-B carboxylesterase lipase family
MyAD_14235	COG1742	UPF0060 membrane protein
MyAD_14250	COG3265	gluconokinase activity
MyAD_14265	COG0778	Nitroreductase
MyAD_14265	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MyAD_14275	COG1177	transmembrane transport
MyAD_14280	COG1176	ABC-type spermidine putrescine transport system, permease component I
MyAD_14300	COG0596	Alpha beta hydrolase
MyAD_14315	COG4681	YaeQ
MyAD_14320	COG2011	ABC-type metal ion transport system permease component
MyAD_14325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MyAD_14330	COG1464	Belongs to the NlpA lipoprotein family
MyAD_14345	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_14390	COG2828	Protein conserved in bacteria
MyAD_14405	COG2828	Protein conserved in bacteria
MyAD_14410	COG3842	ATPase activity
MyAD_14425	COG2199	diguanylate cyclase activity
MyAD_14425	COG2200	EAL domain
MyAD_14425	COG3287	FIST C domain
MyAD_14430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MyAD_14435	COG1953	Uracil, thiamine, allantoin
MyAD_14445	COG3257	ureidoglycine aminohydrolase activity
MyAD_14455	COG1414	Transcriptional regulator
MyAD_14490	COG3002	Belongs to the UPF0753 family
MyAD_14540	COG0747	negative chemotaxis
MyAD_14545	COG0477	Major facilitator Superfamily
MyAD_14570	COG4221	oxidoreductase activity
MyAD_14575	COG1309	transcriptional regulator
MyAD_14595	COG2801	Transposase and inactivated derivatives
MyAD_14620	COG2337	Toxic component of a toxin-antitoxin (TA) module
MyAD_14630	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MyAD_14675	COG1960	acyl-CoA dehydrogenase activity
MyAD_14765	COG1960	acyl-CoA dehydrogenase activity
MyAD_14775	COG0477	Major facilitator Superfamily
MyAD_14815	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MyAD_14825	COG3546	catalase activity
MyAD_14845	COG0545	Peptidyl-prolyl cis-trans isomerase
MyAD_14890	COG1278	Cold shock
MyAD_14915	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
MyAD_14925	COG2124	cytochrome p450
MyAD_14965	COG2807	transmembrane transport
MyAD_14970	COG2186	Transcriptional regulator
MyAD_14980	COG3022	response to hydroperoxide
MyAD_15025	COG1546	Belongs to the CinA family
MyAD_15025	COG1058	Belongs to the CinA family
MyAD_15070	COG2070	2-Nitropropane dioxygenase
MyAD_15080	COG3383	formate dehydrogenase (NAD+) activity
MyAD_15110	COG0745	RESPONSE REGULATOR receiver
MyAD_15115	COG5002	protein histidine kinase activity
MyAD_15155	COG3104	oligopeptide transport
MyAD_15195	COG0745	RESPONSE REGULATOR receiver
MyAD_15205	COG0438	transferase activity, transferring glycosyl groups
MyAD_15255	COG1024	Enoyl-CoA hydratase
MyAD_15275	COG1802	Transcriptional regulator
MyAD_15285	COG1335	isochorismatase
MyAD_15325	COG1252	NADH dehydrogenase
MyAD_15335	COG0668	transmembrane transport
MyAD_15355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MyAD_15380	COG0039	L-malate dehydrogenase activity
MyAD_15395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MyAD_15430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MyAD_15435	COG1252	NADH dehydrogenase
MyAD_15445	COG0829	nickel cation binding
MyAD_15455	COG0830	nickel cation binding
MyAD_15470	COG0831	urea catabolic process
MyAD_15495	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MyAD_15505	COG1253	flavin adenine dinucleotide binding
MyAD_15510	COG1253	flavin adenine dinucleotide binding
MyAD_15540	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MyAD_15540	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MyAD_15560	COG1716	ATPase activity
MyAD_15565	COG0509	glycine decarboxylation via glycine cleavage system
MyAD_15600	COG3976	FMN-binding domain protein
MyAD_15600	COG1053	succinate dehydrogenase
MyAD_15630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MyAD_15640	COG2272	Belongs to the type-B carboxylesterase lipase family
MyAD_15650	COG2076	Multidrug Resistance protein
MyAD_15720	COG1012	belongs to the aldehyde dehydrogenase family
MyAD_15725	COG2814	Major facilitator Superfamily
MyAD_15755	COG1937	Protein conserved in bacteria
MyAD_15775	COG1960	acyl-CoA dehydrogenase activity
MyAD_15805	COG0659	secondary active sulfate transmembrane transporter activity
MyAD_15860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MyAD_15875	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MyAD_15880	COG1122	ATPase activity
MyAD_15885	COG1268	BioY protein
MyAD_15895	COG2814	Major facilitator Superfamily
MyAD_15910	COG0667	Aldo Keto reductase
MyAD_15920	COG1914	H( )-stimulated, divalent metal cation uptake system
MyAD_15940	COG0596	Alpha beta hydrolase
MyAD_15960	COG0454	-acetyltransferase
MyAD_15960	COG0456	acetyltransferase
MyAD_16010	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MyAD_16030	COG1845	cytochrome c oxidase, subunit III
MyAD_16035	COG1960	acyl-CoA dehydrogenase activity
MyAD_16040	COG1309	transcriptional regulator
MyAD_16045	COG0183	Belongs to the thiolase family
MyAD_16060	COG0427	acetyl-CoA hydrolase
MyAD_16075	COG1012	belongs to the aldehyde dehydrogenase family
MyAD_16080	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_16105	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
MyAD_16125	COG2301	Belongs to the HpcH HpaI aldolase family
MyAD_16130	COG1233	COG1233 Phytoene dehydrogenase and related
MyAD_16165	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_16170	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_16175	COG0183	Belongs to the thiolase family
MyAD_16185	COG0183	Belongs to the thiolase family
MyAD_16200	COG4638	Rieske (2fe-2S)
MyAD_16205	COG1024	Enoyl-CoA hydratase
MyAD_16210	COG1024	Enoyl-CoA hydratase
MyAD_16225	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_16235	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MyAD_16260	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MyAD_16265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MyAD_16275	COG2030	dehydratase
MyAD_16340	COG2329	Antibiotic biosynthesis monooxygenase
MyAD_16355	COG1176	ABC-type spermidine putrescine transport system, permease component I
MyAD_16360	COG1177	transmembrane transport
MyAD_16365	COG3842	ATPase activity
MyAD_16395	COG2223	nitrite transmembrane transporter activity
MyAD_16405	COG1012	belongs to the aldehyde dehydrogenase family
MyAD_16410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MyAD_16415	COG0583	DNA-binding transcription factor activity
MyAD_16420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MyAD_16445	COG1012	belongs to the aldehyde dehydrogenase family
MyAD_16460	COG0833	amino acid
MyAD_16465	COG3395	kinase activity
MyAD_16470	COG0235	Class ii aldolase
MyAD_16490	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MyAD_16495	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MyAD_16500	COG0531	amino acid
MyAD_16510	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_16515	COG2197	response regulator
MyAD_16525	COG2814	Major facilitator Superfamily
MyAD_16530	COG1846	Transcriptional regulator
MyAD_16540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MyAD_16595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MyAD_16600	COG4569	acetaldehyde dehydrogenase (acetylating) activity
MyAD_16620	COG1960	acyl-CoA dehydrogenase activity
MyAD_16625	COG1960	acyl-CoA dehydrogenase activity
MyAD_16630	COG3384	dioxygenase
MyAD_16650	COG1064	alcohol dehydrogenase
MyAD_16655	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_16660	COG0596	Alpha beta hydrolase
MyAD_16660	COG0508	dehydrogenase complex catalyzes the overall conversion of
MyAD_16675	COG2801	Transposase and inactivated derivatives
MyAD_16690	COG3046	protein related to deoxyribodipyrimidine photolyase
MyAD_16695	COG0730	response to heat
MyAD_16705	COG1160	GTP binding
MyAD_16710	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MyAD_16720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MyAD_16795	COG0647	UMP catabolic process
MyAD_16825	COG2094	Belongs to the DNA glycosylase MPG family
MyAD_16830	COG2835	tetraacyldisaccharide 4'-kinase activity
MyAD_16845	COG0488	(ABC) transporter
MyAD_16850	COG0165	Argininosuccinate lyase
MyAD_16855	COG0137	argininosuccinate synthase activity
MyAD_16865	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MyAD_16870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MyAD_16875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MyAD_16880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MyAD_16885	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MyAD_16890	COG0072	phenylalanine-tRNA ligase activity
MyAD_16890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MyAD_16895	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MyAD_16910	COG1960	acyl-CoA dehydrogenase activity
MyAD_16915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MyAD_16925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MyAD_16990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MyAD_17005	COG3237	CsbD-like
MyAD_17045	COG0640	Transcriptional regulator
MyAD_17055	COG0798	PFAM Bile acid sodium symporter
MyAD_17105	COG0539	negative regulation of cytoplasmic translation
MyAD_17125	COG0583	DNA-binding transcription factor activity
MyAD_17150	COG1872	DUF167
MyAD_17155	COG0410	ABC transporter
MyAD_17160	COG0411	ABC transporter
MyAD_17190	COG2860	membrane
MyAD_17210	COG0783	Belongs to the Dps family
MyAD_17240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MyAD_17250	COG1271	oxidase subunit
MyAD_17255	COG1294	oxidase, subunit
MyAD_17260	COG4988	ABC transporter
MyAD_17265	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MyAD_17275	COG1946	Acyl-CoA thioesterase
MyAD_17290	COG0070	glutamate synthase
MyAD_17290	COG0069	glutamate synthase activity
MyAD_17290	COG0067	glutamate synthase
MyAD_17305	COG0579	oxidoreductase
MyAD_17310	COG0583	DNA-binding transcription factor activity
MyAD_17335	COG0475	glutathione-regulated potassium exporter activity
MyAD_17345	COG1403	HNH endonuclease
MyAD_17350	COG0589	response to stress
MyAD_17370	COG3290	protein histidine kinase activity
MyAD_17380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MyAD_17380	COG0519	Catalyzes the synthesis of GMP from XMP
MyAD_17405	COG1799	cell septum assembly
MyAD_17425	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MyAD_17435	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MyAD_17455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MyAD_17460	COG0768	penicillin binding
MyAD_17470	COG0275	rRNA processing
MyAD_17515	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MyAD_17530	COG5650	phosphatidylinositol metabolic process
MyAD_17545	COG0003	Pfam Anion-transporting ATPase
MyAD_17560	COG1022	Amp-dependent synthetase and ligase
MyAD_17565	COG0438	transferase activity, transferring glycosyl groups
MyAD_17590	COG1845	cytochrome c oxidase, subunit III
MyAD_17610	COG2318	DinB family
MyAD_17670	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MyAD_17675	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MyAD_17680	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MyAD_17690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MyAD_17695	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MyAD_17730	COG0321	lipoyl(octanoyl) transferase activity
MyAD_17755	COG0174	glutamine synthetase
MyAD_17780	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MyAD_17785	COG0174	glutamine synthetase
MyAD_17810	COG1024	Enoyl-CoA hydratase
MyAD_17835	COG0328	RNA-DNA hybrid ribonuclease activity
MyAD_17835	COG0406	alpha-ribazole phosphatase activity
MyAD_17930	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MyAD_17940	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MyAD_17945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MyAD_17970	COG0583	DNA-binding transcription factor activity
MyAD_18015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MyAD_18040	COG0028	Belongs to the TPP enzyme family
MyAD_18055	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_18070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MyAD_18075	COG2252	PERMEase
MyAD_18085	COG1305	Transglutaminase-like
MyAD_18100	COG5002	protein histidine kinase activity
MyAD_18100	COG5001	Diguanylate cyclase
MyAD_18100	COG3447	MASE1 domain protein
MyAD_18120	COG2124	cytochrome p450
MyAD_18120	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MyAD_18150	COG2801	Transposase and inactivated derivatives
MyAD_18180	COG0765	amino acid transport
MyAD_18195	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MyAD_18200	COG4948	Mandelate Racemase Muconate Lactonizing
MyAD_18205	COG0800	Aldolase
MyAD_18230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MyAD_18255	COG2814	Major facilitator Superfamily
MyAD_18295	COG0358	DNA primase activity
MyAD_18300	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MyAD_18320	COG0423	glycine-tRNA ligase activity
MyAD_18345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MyAD_18350	COG1381	Involved in DNA repair and RecF pathway recombination
MyAD_18380	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MyAD_18395	COG0484	heat shock protein binding
MyAD_18400	COG1420	regulation of RNA biosynthetic process
MyAD_18430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MyAD_18455	COG1021	2,3-dihydroxybenzoate-AMP ligase
MyAD_18485	COG1309	transcriptional regulator
MyAD_18505	COG4208	sulfate ABC transporter
MyAD_18515	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MyAD_18530	COG3387	PFAM Glycoside hydrolase 15-related
MyAD_18540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MyAD_18545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MyAD_18580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MyAD_18590	COG2011	ABC-type metal ion transport system permease component
MyAD_18605	COG1120	ATPase activity
MyAD_18610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MyAD_18630	COG0517	IMP dehydrogenase activity
MyAD_18630	COG0516	GMP reductase activity
MyAD_18635	COG1234	tRNA 3'-trailer cleavage
MyAD_18640	COG1305	Transglutaminase-like
MyAD_18670	COG1555	photosystem II stabilization
MyAD_18670	COG1596	polysaccharide export
MyAD_18675	COG0346	lactoylglutathione lyase activity
MyAD_18705	COG2755	lipolytic protein G-D-S-L family
MyAD_18710	COG0406	alpha-ribazole phosphatase activity
MyAD_18715	COG0799	negative regulation of ribosome biogenesis
MyAD_18730	COG0542	response to heat
MyAD_18735	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MyAD_18740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MyAD_18775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MyAD_18780	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MyAD_18785	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MyAD_18790	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MyAD_18795	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MyAD_18800	COG1530	ribonuclease E activity
MyAD_18805	COG0105	UTP biosynthetic process
MyAD_18815	COG0285	dihydrofolate synthase activity
MyAD_18820	COG0525	valine-tRNA ligase activity
MyAD_18825	COG3268	Saccharopine dehydrogenase
MyAD_18830	COG1506	peptidase
MyAD_18830	COG0823	Involved in the tonB-independent uptake of proteins
MyAD_18835	COG0004	ammonium transporteR
MyAD_18865	COG1388	LysM domain
MyAD_18870	COG1388	LysM domain
MyAD_18875	COG0746	molybdenum cofactor guanylyltransferase activity
MyAD_18880	COG1013	pyruvate-flavodoxin oxidoreductase activity
MyAD_18885	COG0674	pyruvate-flavodoxin oxidoreductase activity
MyAD_18885	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MyAD_18895	COG1609	Transcriptional regulator
MyAD_18900	COG0673	inositol 2-dehydrogenase activity
MyAD_18905	COG1082	Xylose isomerase domain protein TIM barrel
MyAD_18910	COG3832	glyoxalase III activity
MyAD_18920	COG1172	Belongs to the binding-protein-dependent transport system permease family
MyAD_18935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MyAD_18945	COG3718	enzyme involved in inositol metabolism
MyAD_18950	COG3962	Belongs to the TPP enzyme family
MyAD_18980	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MyAD_18985	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MyAD_18995	COG0740	serine-type endopeptidase activity
MyAD_19000	COG0740	serine-type endopeptidase activity
MyAD_19005	COG0544	peptidyl-prolyl cis-trans isomerase activity
MyAD_19040	COG4974	Belongs to the 'phage' integrase family
MyAD_19155	COG4221	oxidoreductase activity
MyAD_19175	COG2239	Acts as a magnesium transporter
MyAD_19180	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MyAD_19195	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MyAD_19215	COG0366	Alpha amylase catalytic
MyAD_19230	COG2902	Dehydrogenase
MyAD_19285	COG4251	negative regulation of phosphorylation
MyAD_19320	COG0508	dehydrogenase complex catalyzes the overall conversion of
MyAD_19345	COG1960	acyl-CoA dehydrogenase activity
MyAD_19355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MyAD_19375	COG0300	oxidoreductase activity
MyAD_19380	COG0433	COG0433 Predicted ATPase
MyAD_19420	COG1414	Transcriptional regulator
MyAD_19430	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_19495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MyAD_19500	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MyAD_19515	COG1960	acyl-CoA dehydrogenase activity
MyAD_19520	COG0183	Belongs to the thiolase family
MyAD_19525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MyAD_19615	COG0477	Major facilitator Superfamily
MyAD_19620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MyAD_19625	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MyAD_19655	COG3191	aminopeptidase activity
MyAD_19665	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MyAD_19670	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MyAD_19685	COG4257	antibiotic catabolic process
MyAD_19690	COG0058	SHG alpha-glucan phosphorylase activity
MyAD_19695	COG0366	Alpha amylase catalytic
MyAD_19700	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MyAD_19710	COG2409	Drug exporters of the RND superfamily
MyAD_19715	COG0183	Belongs to the thiolase family
MyAD_19730	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MyAD_19740	COG2066	Belongs to the glutaminase family
MyAD_19740	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MyAD_19755	COG0586	Pfam SNARE associated Golgi protein
MyAD_19765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MyAD_19785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MyAD_19800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MyAD_19805	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MyAD_19810	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MyAD_19815	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MyAD_19820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MyAD_19820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MyAD_19825	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MyAD_19830	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MyAD_19835	COG0356	it plays a direct role in the translocation of protons across the membrane
MyAD_19845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MyAD_19855	COG2890	protein-(glutamine-N5) methyltransferase activity
MyAD_19860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MyAD_19870	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_19875	COG1309	transcriptional regulator
MyAD_19890	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MyAD_19895	COG0460	homoserine dehydrogenase
MyAD_19900	COG0019	diaminopimelate decarboxylase activity
MyAD_19905	COG0018	arginyl-trna synthetase
MyAD_19915	COG1309	transcriptional regulator
MyAD_19920	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_19945	COG2197	response regulator
MyAD_19965	COG0277	FAD linked oxidase domain protein
MyAD_19965	COG0247	lactate metabolic process
MyAD_19980	COG2318	DinB family
MyAD_19985	COG1218	3'(2'),5'-bisphosphate nucleotidase
MyAD_19995	COG0175	sulfate reduction
MyAD_20000	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MyAD_20010	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MyAD_20015	COG2205	protein histidine kinase activity
MyAD_20020	COG0745	RESPONSE REGULATOR receiver
MyAD_20090	COG1132	(ABC) transporter
MyAD_20145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MyAD_20165	COG0277	FAD linked oxidase domain protein
MyAD_20180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MyAD_20230	COG2814	Major facilitator Superfamily
MyAD_20240	COG0508	dehydrogenase complex catalyzes the overall conversion of
MyAD_20240	COG0567	Dehydrogenase, E1 component
MyAD_20265	COG0598	Magnesium transport protein CorA
MyAD_20315	COG2239	Acts as a magnesium transporter
MyAD_20340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MyAD_20345	COG5662	AntiSigma factor
MyAD_20350	COG1595	DNA-templated transcription, initiation
MyAD_20365	COG1309	transcriptional regulator
MyAD_20370	COG1131	(ABC) transporter
MyAD_20375	COG3559	Exporter of polyketide antibiotics
MyAD_20390	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MyAD_20395	COG0297	glycogen (starch) synthase activity
MyAD_20400	COG0519	Catalyzes the synthesis of GMP from XMP
MyAD_20410	COG0463	Glycosyl transferase, family 2
MyAD_20425	COG1611	Belongs to the LOG family
MyAD_20440	COG0488	(ABC) transporter
MyAD_20445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MyAD_20450	COG2171	N-acyltransferase activity
MyAD_20460	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_20475	COG0506	proline dehydrogenase activity
MyAD_20480	COG1012	belongs to the aldehyde dehydrogenase family
MyAD_20500	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MyAD_20510	COG1902	pentaerythritol trinitrate reductase activity
MyAD_20510	COG0446	pyridine nucleotide-disulphide oxidoreductase
MyAD_20515	COG2353	YceI-like domain
MyAD_20570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MyAD_20580	COG2376	Dihydroxyacetone kinase
MyAD_20585	COG0747	negative chemotaxis
MyAD_20620	COG1051	belongs to the nudix hydrolase family
MyAD_20645	COG1473	amidohydrolase
MyAD_20655	COG3275	phosphorelay sensor kinase activity
MyAD_20660	COG3279	Response regulator of the LytR AlgR family
MyAD_20670	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MyAD_20680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MyAD_20695	COG3467	pyridoxamine 5'-phosphate
MyAD_20710	COG2072	flavoprotein involved in K transport
MyAD_20725	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MyAD_20740	COG2409	Drug exporters of the RND superfamily
MyAD_20755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MyAD_20760	COG1024	Enoyl-CoA hydratase
MyAD_20775	COG0702	epimerase
MyAD_20785	COG4977	sequence-specific DNA binding
MyAD_20790	COG2271	Major facilitator Superfamily
MyAD_20795	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MyAD_20810	COG0183	Belongs to the thiolase family
MyAD_20815	COG2186	Transcriptional regulator
MyAD_20825	COG1051	belongs to the nudix hydrolase family
MyAD_20900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MyAD_20905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MyAD_20920	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MyAD_20970	COG0012	GTP binding
MyAD_21020	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_21055	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MyAD_21065	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MyAD_21075	COG0572	uridine kinase
MyAD_21090	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MyAD_21100	COG3631	Ketosteroid isomerase-related protein
MyAD_21105	COG1331	Highly conserved protein containing a thioredoxin domain
MyAD_21115	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MyAD_21125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MyAD_21140	COG5473	translation initiation factor activity
MyAD_21150	COG1714	RDD family
MyAD_21160	COG0657	acetylesterase activity
MyAD_21170	COG0183	Belongs to the thiolase family
MyAD_21175	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MyAD_21190	COG1024	Enoyl-CoA hydratase
MyAD_21230	COG3804	dihydrodipicolinate reductase
MyAD_21250	COG0183	Belongs to the thiolase family
MyAD_21265	COG4565	transcriptional regulatory protein
MyAD_21270	COG3290	protein histidine kinase activity
MyAD_21275	COG1301	dicarboxylic acid transport
MyAD_21290	COG1126	abc transporter atp-binding protein
MyAD_21295	COG0765	amino acid transport
MyAD_21345	COG1012	belongs to the aldehyde dehydrogenase family
MyAD_21365	COG1113	amino acid transport
MyAD_21375	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
MyAD_21460	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MyAD_21465	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MyAD_21500	COG3842	ATPase activity
MyAD_21515	COG2217	Heavy metal translocating P-type atpase
MyAD_21520	COG0640	Transcriptional regulator
MyAD_21585	COG2837	iron assimilation
MyAD_21600	COG0477	Major facilitator Superfamily
MyAD_21605	COG1309	transcriptional regulator
MyAD_21610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MyAD_21615	COG1024	Enoyl-CoA hydratase
MyAD_21635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MyAD_21645	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_21655	COG3956	TIGRFAM MazG family protein
MyAD_21710	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MyAD_21725	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_21730	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MyAD_21740	COG3583	domain protein
MyAD_21745	COG0084	hydrolase, TatD family'
MyAD_21755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MyAD_21760	COG1522	sequence-specific DNA binding
MyAD_21765	COG0446	pyridine nucleotide-disulphide oxidoreductase
MyAD_21775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MyAD_21810	COG0415	Belongs to the DNA photolyase family
MyAD_21815	COG2235	arginine
MyAD_21845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MyAD_21850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MyAD_21850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MyAD_21865	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MyAD_21880	COG5001	Diguanylate cyclase
MyAD_21930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MyAD_21935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MyAD_21965	COG0521	Mo-molybdopterin cofactor biosynthetic process
MyAD_21965	COG0315	cyclic pyranopterin monophosphate synthase activity
MyAD_21970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MyAD_21980	COG0745	RESPONSE REGULATOR receiver
MyAD_22000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MyAD_22015	COG1024	Enoyl-CoA hydratase
MyAD_22025	COG4867	von Willebrand factor, type A
MyAD_22090	COG0045	succinate-CoA ligase (ADP-forming) activity
MyAD_22120	COG0166	Belongs to the GPI family
MyAD_22140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MyAD_22150	COG1950	PFAM Membrane protein of
MyAD_22180	COG2814	Major facilitator Superfamily
MyAD_22205	COG2226	methyltransferase
MyAD_22220	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MyAD_22225	COG3706	GGDEF domain
MyAD_22235	COG0328	RNA-DNA hybrid ribonuclease activity
MyAD_22245	COG1793	dna ligase
MyAD_22245	COG3285	dna ligase
MyAD_22250	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MyAD_22270	COG0531	amino acid
MyAD_22275	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MyAD_22310	COG3415	Transposase
MyAD_22310	COG2801	Transposase and inactivated derivatives
MyAD_22350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MyAD_22355	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MyAD_22380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MyAD_22380	COG1017	nitric oxide dioxygenase activity
MyAD_22385	COG1335	isochorismatase
MyAD_22395	COG4251	negative regulation of phosphorylation
MyAD_22400	COG0784	Response regulator, receiver
MyAD_22415	COG0747	negative chemotaxis
MyAD_22425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MyAD_22430	COG4172	Belongs to the ABC transporter superfamily
MyAD_22440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MyAD_22445	COG1595	DNA-templated transcription, initiation
MyAD_22470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MyAD_22500	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MyAD_22515	COG1024	Enoyl-CoA hydratase
MyAD_22525	COG2205	protein histidine kinase activity
MyAD_22530	COG0745	RESPONSE REGULATOR receiver
MyAD_22540	COG2259	Doxx family
MyAD_22560	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_22565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MyAD_22570	COG2197	response regulator
MyAD_22575	COG1132	(ABC) transporter
MyAD_22600	COG0545	Peptidyl-prolyl cis-trans isomerase
MyAD_22610	COG1846	Transcriptional regulator
MyAD_22665	COG3396	Phenylacetate-CoA oxygenase
MyAD_22685	COG1403	HNH endonuclease
MyAD_22700	COG1819	glycosyl
MyAD_22750	COG0435	Glutathione S-transferase
MyAD_22755	COG1278	Cold shock
MyAD_22785	COG0521	Mo-molybdopterin cofactor biosynthetic process
MyAD_22785	COG0315	cyclic pyranopterin monophosphate synthase activity
MyAD_22830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MyAD_22845	COG4977	sequence-specific DNA binding
MyAD_22850	COG1024	Enoyl-CoA hydratase
MyAD_22850	COG1250	3-hydroxyacyl-CoA dehydrogenase
MyAD_22855	COG0183	Belongs to the thiolase family
MyAD_22860	COG1902	pentaerythritol trinitrate reductase activity
MyAD_22875	COG0832	Belongs to the urease beta subunit family
MyAD_22875	COG0831	urea catabolic process
MyAD_22880	COG0804	urea catabolic process
MyAD_22885	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MyAD_22890	COG0829	nickel cation binding
MyAD_22915	COG0531	amino acid
MyAD_22930	COG1953	Uracil, thiamine, allantoin
MyAD_22940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MyAD_22965	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MyAD_22990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MyAD_22995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MyAD_23005	COG1233	COG1233 Phytoene dehydrogenase and related
MyAD_23055	COG2815	serine threonine protein kinase
MyAD_23055	COG0515	serine threonine protein kinase
MyAD_23095	COG1064	alcohol dehydrogenase
MyAD_23100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MyAD_23120	COG0456	acetyltransferase
MyAD_23125	COG0745	RESPONSE REGULATOR receiver
MyAD_23135	COG3118	belongs to the thioredoxin family
MyAD_23145	COG2897	thiosulfate sulfurtransferase activity
MyAD_23160	COG4044	May play a role in the intracellular transport of hydrophobic ligands
MyAD_23170	COG0354	folic acid binding
MyAD_23180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MyAD_23215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MyAD_23230	COG1362	aminopeptidase activity
MyAD_23235	COG2837	iron assimilation
MyAD_23255	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MyAD_23280	COG0386	Belongs to the glutathione peroxidase family
MyAD_23300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MyAD_23305	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MyAD_23310	COG1120	ATPase activity
MyAD_23315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MyAD_23330	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MyAD_23335	COG0531	amino acid
MyAD_23355	COG2124	cytochrome p450
MyAD_23385	COG1012	belongs to the aldehyde dehydrogenase family
MyAD_23400	COG4221	oxidoreductase activity
MyAD_23405	COG2124	cytochrome p450
MyAD_23435	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_23445	COG2205	protein histidine kinase activity
MyAD_23450	COG0745	RESPONSE REGULATOR receiver
MyAD_23490	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MyAD_23490	COG3608	succinylglutamate desuccinylase aspartoacylase
MyAD_23505	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MyAD_23525	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MyAD_23540	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MyAD_23570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MyAD_23600	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MyAD_23605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MyAD_23610	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_23620	COG1960	acyl-CoA dehydrogenase activity
MyAD_23625	COG1960	acyl-CoA dehydrogenase activity
MyAD_23640	COG1902	pentaerythritol trinitrate reductase activity
MyAD_23650	COG1309	transcriptional regulator
MyAD_23655	COG2070	2-Nitropropane dioxygenase
MyAD_23665	COG1024	Enoyl-CoA hydratase
MyAD_23685	COG0477	Major facilitator Superfamily
MyAD_23695	COG0745	RESPONSE REGULATOR receiver
MyAD_23700	COG2124	cytochrome p450
MyAD_23705	COG4689	acetoacetate decarboxylase
MyAD_23710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MyAD_23725	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MyAD_23740	COG4638	Rieske (2fe-2S)
MyAD_23770	COG0514	ATP-dependent DNA helicase (RecQ)
MyAD_23795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MyAD_23805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MyAD_23810	COG4569	acetaldehyde dehydrogenase (acetylating) activity
MyAD_23820	COG1053	succinate dehydrogenase
MyAD_23870	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MyAD_23875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MyAD_23880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MyAD_23915	COG0438	transferase activity, transferring glycosyl groups
MyAD_23920	COG2244	polysaccharide biosynthetic process
MyAD_23950	COG0438	transferase activity, transferring glycosyl groups
MyAD_23965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MyAD_23970	COG1231	oxidoreductase activity
MyAD_23980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MyAD_23985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MyAD_23990	COG2201	protein-glutamate methylesterase activity
MyAD_24025	COG2030	dehydratase
MyAD_24030	COG1960	acyl-CoA dehydrogenase activity
MyAD_24035	COG1960	acyl-CoA dehydrogenase activity
MyAD_24040	COG2124	cytochrome p450
MyAD_24045	COG0183	Belongs to the thiolase family
MyAD_24065	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_24075	COG1024	Enoyl-CoA hydratase
MyAD_24100	COG2233	PERMEase
MyAD_24115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MyAD_24120	COG0402	S-adenosylhomocysteine deaminase activity
MyAD_24140	COG1309	transcriptional regulator
MyAD_24150	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_24155	COG1960	acyl-CoA dehydrogenase activity
MyAD_24160	COG0318	PFAM AMP-dependent synthetase and ligase
MyAD_24165	COG1960	acyl-CoA dehydrogenase activity
MyAD_24170	COG1960	acyl-CoA dehydrogenase activity
MyAD_24175	COG1960	acyl-CoA dehydrogenase activity
MyAD_24185	COG0436	Aminotransferase
MyAD_24200	COG1070	Carbohydrate kinase
MyAD_24205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MyAD_24210	COG1028	Short-chain dehydrogenase reductase Sdr
MyAD_24220	COG0583	DNA-binding transcription factor activity
MyAD_24235	COG0346	lactoylglutathione lyase activity
MyAD_24250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MyAD_24260	COG1960	acyl-CoA dehydrogenase activity
MyAD_24265	COG1309	transcriptional regulator
MyAD_24280	COG1609	Transcriptional regulator
MyAD_24285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MyAD_24290	COG1121	(ABC) transporter
MyAD_24300	COG0523	cobalamin synthesis protein
MyAD_24310	COG0803	Belongs to the bacterial solute-binding protein 9 family
MyAD_24315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MyAD_24320	COG1121	(ABC) transporter
MyAD_24325	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MyAD_24340	COG0701	Predicted permease
MyAD_24350	COG0640	Transcriptional regulator
MyAD_24360	COG0778	Nitroreductase
MyAD_24365	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MyAD_24370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MyAD_24375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MyAD_24400	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MyAD_24405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MyAD_24415	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MyAD_24420	COG1329	Transcriptional regulator
MyAD_24430	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MyAD_24435	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MyAD_24445	COG0288	reversible hydration of carbon dioxide
MyAD_24450	COG1194	a g-specific adenine glycosylase
MyAD_24495	COG0542	response to heat
MyAD_24505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MyAD_24510	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MyAD_24520	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MyAD_24555	COG0302	gtp cyclohydrolase
MyAD_24565	COG2267	carboxylic ester hydrolase activity
MyAD_24575	COG1063	alcohol dehydrogenase
MyAD_24580	COG2968	Membrane
MyAD_24625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MyAD_24630	COG4948	Mandelate Racemase Muconate Lactonizing
MyAD_24635	COG1414	Transcriptional regulator
MyAD_24645	COG4608	Belongs to the ABC transporter superfamily
MyAD_24650	COG0444	Belongs to the ABC transporter superfamily
MyAD_24660	COG0601	transmembrane transport
MyAD_24665	COG0747	negative chemotaxis
MyAD_24670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MyAD_24675	COG0583	DNA-binding transcription factor activity
MyAD_24695	COG4948	Mandelate Racemase Muconate Lactonizing
MyAD_24700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MyAD_24760	COG0470	DNA polymerase III
MyAD_24770	COG1754	DNA topoisomerase type I activity
MyAD_24770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MyAD_24780	COG1278	Cold shock
MyAD_24785	COG1111	helicase
MyAD_24785	COG1205	dead DEAH box helicase
MyAD_24840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MyAD_24865	COG0494	nUDIX hydrolase
MyAD_24875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MyAD_24890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MyAD_24895	COG0251	oxidation-reduction process
MyAD_24925	COG1408	metallophosphoesterase
MyAD_24930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MyAD_24955	COG1946	Acyl-CoA thioesterase
MyAD_24980	COG0714	Associated with various cellular activities
MyAD_25000	COG1309	transcriptional regulator
MyAD_25005	COG0477	Major facilitator Superfamily
MyAD_25010	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
MyAD_25050	COG4585	Histidine kinase
MyAD_25055	COG1454	alcohol dehydrogenase
MyAD_25065	COG0542	response to heat
MyAD_25075	COG1403	HNH endonuclease
MyAD_25085	COG1733	regulation of RNA biosynthetic process
MyAD_25090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MyAD_25095	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
MyAD_25100	COG0121	glutamine amidotransferase
MyAD_25105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MyAD_25110	COG3572	ergothioneine biosynthetic process
MyAD_25160	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MyAD_25165	COG2218	PFAM glutamate synthase alpha subunit domain protein
MyAD_25170	COG0069	glutamate synthase activity
MyAD_25175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MyAD_25220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MyAD_25225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MyAD_25230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MyAD_25240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MyAD_25245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MyAD_25250	COG0860	N-Acetylmuramoyl-L-alanine amidase
MyAD_25265	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MyAD_25275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MyAD_25290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MyAD_25300	COG3285	dna ligase
MyAD_25300	COG1793	dna ligase
MyAD_25305	COG1793	dna ligase
MyAD_25310	COG1960	acyl-CoA dehydrogenase activity