locus-tag	class	description
IG195_00010	COG1435	thymidine kinase activity
IG195_00025	COG0045	succinate-CoA ligase (ADP-forming) activity
IG195_00025	COG1042	CoA-binding domain protein
IG195_00025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IG195_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IG195_00050	COG4988	ABC transporter
IG195_00055	COG1294	oxidase, subunit
IG195_00060	COG1271	oxidase subunit
IG195_00085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IG195_00105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IG195_00110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IG195_00115	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG195_00125	COG1764	response to oxidative stress
IG195_00130	COG0793	Belongs to the peptidase S41A family
IG195_00130	COG4946	Tricorn protease homolog
IG195_00135	COG1090	epimerase
IG195_00145	COG0321	lipoyl(octanoyl) transferase activity
IG195_00150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IG195_00180	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IG195_00185	COG0174	glutamine synthetase
IG195_00190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IG195_00210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IG195_00215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IG195_00230	COG0587	DNA-directed DNA polymerase activity
IG195_00240	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IG195_00255	COG1799	cell septum assembly
IG195_00260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IG195_00270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IG195_00280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IG195_00285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IG195_00295	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IG195_00300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IG195_00310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IG195_00315	COG0768	penicillin binding
IG195_00325	COG0275	rRNA processing
IG195_00330	COG2001	Belongs to the MraZ family
IG195_00340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IG195_00350	COG0142	geranyltranstransferase activity
IG195_00360	COG1388	LysM domain
IG195_00360	COG3942	CHAP domain
IG195_00365	COG2815	serine threonine protein kinase
IG195_00365	COG0515	serine threonine protein kinase
IG195_00370	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IG195_00395	COG1940	carbohydrate kinase activity
IG195_00405	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IG195_00430	COG1716	ATPase activity
IG195_00435	COG0509	glycine decarboxylation via glycine cleavage system
IG195_00440	COG2814	Major facilitator Superfamily
IG195_00445	COG1846	Transcriptional regulator
IG195_00540	COG0582	viral genome integration into host DNA
IG195_00550	COG1160	GTP binding
IG195_00560	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IG195_00575	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IG195_00580	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IG195_00590	COG1301	dicarboxylic acid transport
IG195_00595	COG3290	protein histidine kinase activity
IG195_00610	COG2079	MmgE PrpD family protein
IG195_00615	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IG195_00645	COG0504	CTP synthase activity
IG195_00650	COG0497	DNA recombination
IG195_00655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IG195_00670	COG0647	UMP catabolic process
IG195_00695	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IG195_00705	COG2094	Belongs to the DNA glycosylase MPG family
IG195_00720	COG0165	Argininosuccinate lyase
IG195_00725	COG0137	argininosuccinate synthase activity
IG195_00730	COG1438	arginine binding
IG195_00735	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IG195_00740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IG195_00745	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IG195_00750	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IG195_00755	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IG195_00770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IG195_00770	COG0072	phenylalanine-tRNA ligase activity
IG195_00775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IG195_00790	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IG195_00800	COG2816	NAD+ diphosphatase activity
IG195_00805	COG2814	Major facilitator Superfamily
IG195_00810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IG195_00815	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IG195_00820	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IG195_00825	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IG195_00845	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IG195_00855	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IG195_00860	COG0131	Imidazoleglycerol-phosphate dehydratase
IG195_00865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IG195_00870	COG1388	LysM domain
IG195_00875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IG195_00885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IG195_00890	COG2813	Specifically methylates the guanine in position
IG195_00895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IG195_00900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IG195_00905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IG195_00910	COG2137	regulation of response to DNA damage stimulus
IG195_00915	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IG195_00930	COG1396	sequence-specific DNA binding
IG195_00935	COG1546	Belongs to the CinA family
IG195_00935	COG1058	Belongs to the CinA family
IG195_00945	COG1674	ftsk spoiiie
IG195_00950	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IG195_00955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG195_00975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IG195_00985	COG0521	Mo-molybdopterin cofactor biosynthetic process
IG195_01005	COG2205	protein histidine kinase activity
IG195_01010	COG0745	RESPONSE REGULATOR receiver
IG195_01030	COG0612	Peptidase, M16
IG195_01035	COG1185	polyribonucleotide nucleotidyltransferase activity
IG195_01040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IG195_01060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IG195_01070	COG0590	tRNA wobble adenosine to inosine editing
IG195_01075	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IG195_01080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IG195_01080	COG0481	GTPase activity
IG195_01095	COG0779	Required for maturation of 30S ribosomal subunits
IG195_01115	COG0442	prolyl-tRNA aminoacylation
IG195_01120	COG1131	(ABC) transporter
IG195_01140	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IG195_01150	COG0750	zinc metalloprotease
IG195_01155	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IG195_01170	COG1653	transport
IG195_01175	COG1175	transmembrane transport
IG195_01185	COG0673	inositol 2-dehydrogenase activity
IG195_01220	COG1960	acyl-CoA dehydrogenase activity
IG195_01230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IG195_01240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IG195_01245	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG195_01250	COG0022	dehydrogenase e1 component
IG195_01260	COG1522	sequence-specific DNA binding
IG195_01270	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IG195_01270	COG1796	DNA polymerase
IG195_01275	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IG195_01285	COG3275	phosphorelay sensor kinase activity
IG195_01300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IG195_01315	COG0575	Belongs to the CDS family
IG195_01320	COG0233	cytoplasmic translational termination
IG195_01325	COG0528	UMP kinase activity
IG195_01330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IG195_01335	COG0052	Belongs to the universal ribosomal protein uS2 family
IG195_01360	COG0297	glycogen (starch) synthase activity
IG195_01390	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IG195_01395	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IG195_01415	COG0358	DNA primase activity
IG195_01440	COG0423	glycine-tRNA ligase activity
IG195_01475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IG195_01480	COG2873	o-acetylhomoserine
IG195_01510	COG1940	carbohydrate kinase activity
IG195_01515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IG195_01520	COG1228	amidohydrolase
IG195_01530	COG0156	8-amino-7-oxononanoate synthase activity
IG195_01535	COG1063	alcohol dehydrogenase
IG195_01545	COG0673	inositol 2-dehydrogenase activity
IG195_01560	COG0395	ABC-type sugar transport system, permease component
IG195_01565	COG4209	transmembrane transport
IG195_01570	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IG195_01575	COG0154	amidase activity
IG195_01580	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IG195_01585	COG2851	Citrate transporter
IG195_01595	COG4565	transcriptional regulatory protein
IG195_01600	COG0251	oxidation-reduction process
IG195_01610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG195_01615	COG0483	inositol monophosphate 1-phosphatase activity
IG195_01620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IG195_01630	COG1674	ftsk spoiiie
IG195_01670	COG0714	Associated with various cellular activities
IG195_01705	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IG195_01720	COG1823	symporter activity
IG195_01735	COG1309	transcriptional regulator
IG195_01740	COG2409	Drug exporters of the RND superfamily
IG195_01745	COG0424	maF-like protein
IG195_01750	COG4770	biotin carboxylase activity
IG195_01755	COG0477	Major facilitator Superfamily
IG195_01760	COG2223	nitrite transmembrane transporter activity
IG195_01765	COG0243	molybdopterin cofactor binding
IG195_01795	COG1621	beta-fructofuranosidase activity
IG195_01800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IG195_01810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IG195_01830	COG0659	secondary active sulfate transmembrane transporter activity
IG195_01835	COG2824	Alkylphosphonate utilization operon protein PhnA
IG195_01840	COG2814	Major facilitator Superfamily
IG195_01850	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_01890	COG0446	pyridine nucleotide-disulphide oxidoreductase
IG195_01895	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IG195_01910	COG0297	glycogen (starch) synthase activity
IG195_01930	COG1988	membrane-bound metal-dependent
IG195_01940	COG0702	epimerase
IG195_01955	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IG195_01960	COG0822	iron-sulfur transferase activity
IG195_01985	COG0193	aminoacyl-tRNA hydrolase activity
IG195_01990	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IG195_01995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IG195_02000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IG195_02010	COG1309	transcriptional regulator
IG195_02020	COG0488	(ABC) transporter
IG195_02025	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IG195_02030	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IG195_02035	COG3583	domain protein
IG195_02040	COG0084	hydrolase, TatD family'
IG195_02045	COG0714	Associated with various cellular activities
IG195_02095	COG1376	ErfK ybiS ycfS ynhG family protein
IG195_02100	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IG195_02150	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IG195_02160	COG1482	cell wall glycoprotein biosynthetic process
IG195_02170	COG1494	fructose-1,6-bisphosphatase
IG195_02180	COG0288	reversible hydration of carbon dioxide
IG195_02185	COG0114	fumarate hydratase activity
IG195_02205	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IG195_02210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IG195_02220	COG1331	Highly conserved protein containing a thioredoxin domain
IG195_02230	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IG195_02240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IG195_02250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IG195_02260	COG2017	converts alpha-aldose to the beta-anomer
IG195_02270	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IG195_02275	COG0183	Belongs to the thiolase family
IG195_02285	COG0559	Belongs to the binding-protein-dependent transport system permease family
IG195_02325	COG1252	NADH dehydrogenase
IG195_02350	COG0148	phosphopyruvate hydratase activity
IG195_02360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IG195_02365	COG0586	Pfam SNARE associated Golgi protein
IG195_02385	COG1079	Belongs to the binding-protein-dependent transport system permease family
IG195_02390	COG4603	Belongs to the binding-protein-dependent transport system permease family
IG195_02395	COG3845	ABC transporter
IG195_02400	COG1744	ABC transporter substrate-binding protein PnrA-like
IG195_02405	COG2130	NADP-dependent
IG195_02410	COG1764	response to oxidative stress
IG195_02415	COG1846	Transcriptional regulator
IG195_02420	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IG195_02420	COG1473	amidohydrolase
IG195_02430	COG2009	succinate dehydrogenase
IG195_02445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IG195_02480	COG0180	Tryptophanyl-tRNA synthetase
IG195_02505	COG1131	(ABC) transporter
IG195_02510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IG195_02515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IG195_02540	COG0531	amino acid
IG195_02545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IG195_02560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IG195_02570	COG1129	ABC transporter
IG195_02575	COG4214	carbohydrate transport
IG195_02580	COG4213	ABC transporter substrate-binding protein
IG195_02585	COG0577	efflux transmembrane transporter activity
IG195_02585	COG1136	(ABC) transporter
IG195_02590	COG1136	(ABC) transporter
IG195_02590	COG0577	efflux transmembrane transporter activity
IG195_02600	COG0673	inositol 2-dehydrogenase activity
IG195_02615	COG2838	Isocitrate dehydrogenase
IG195_02625	COG0138	bifunctional purine biosynthesis protein purh
IG195_02635	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IG195_02640	COG2271	Major facilitator Superfamily
IG195_02670	COG0484	heat shock protein binding
IG195_02675	COG0071	Belongs to the small heat shock protein (HSP20) family
IG195_02700	COG3415	Transposase
IG195_02700	COG2801	Transposase and inactivated derivatives
IG195_02715	COG1278	Cold shock
IG195_02720	COG4942	peptidase
IG195_02750	COG1136	(ABC) transporter
IG195_02750	COG0577	efflux transmembrane transporter activity
IG195_02765	COG2072	flavoprotein involved in K transport
IG195_02785	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IG195_02785	COG0237	dephospho-CoA kinase activity
IG195_02835	COG3973	AAA domain
IG195_02850	COG0477	Major facilitator Superfamily
IG195_02865	COG1609	Transcriptional regulator
IG195_02885	COG1472	Belongs to the glycosyl hydrolase 3 family
IG195_02905	COG0402	S-adenosylhomocysteine deaminase activity
IG195_02915	COG1653	transport
IG195_02925	COG4209	transmembrane transport
IG195_02935	COG0640	Transcriptional regulator
IG195_02945	COG1254	Belongs to the acylphosphatase family
IG195_02955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IG195_02970	COG3835	regulator
IG195_02980	COG0511	ligase activity, forming carbon-carbon bonds
IG195_02985	COG0439	Biotin carboxylase
IG195_02990	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IG195_02995	COG1984	allophanate hydrolase subunit 2
IG195_03030	COG0149	triose-phosphate isomerase activity
IG195_03035	COG2271	Major facilitator Superfamily
IG195_03040	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_03045	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG195_03050	COG0698	ribose 5-phosphate isomerase
IG195_03055	COG2376	Dihydroxyacetone kinase
IG195_03070	COG1902	pentaerythritol trinitrate reductase activity
IG195_03075	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IG195_03095	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IG195_03115	COG1396	sequence-specific DNA binding
IG195_03130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG195_03135	COG1024	Enoyl-CoA hydratase
IG195_03145	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_03150	COG1012	belongs to the aldehyde dehydrogenase family
IG195_03165	COG2205	protein histidine kinase activity
IG195_03180	COG1401	restriction endodeoxyribonuclease activity
IG195_03190	COG3142	Participates in the control of copper homeostasis
IG195_03220	COG0028	Belongs to the TPP enzyme family
IG195_03230	COG1396	sequence-specific DNA binding
IG195_03270	COG0673	inositol 2-dehydrogenase activity
IG195_03280	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG195_03290	COG2188	Transcriptional regulator
IG195_03295	COG3718	enzyme involved in inositol metabolism
IG195_03300	COG1082	Xylose isomerase domain protein TIM barrel
IG195_03305	COG0673	inositol 2-dehydrogenase activity
IG195_03320	COG3962	Belongs to the TPP enzyme family
IG195_03330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG195_03335	COG1942	4-Oxalocrotonate Tautomerase
IG195_03345	COG0045	succinate-CoA ligase (ADP-forming) activity
IG195_03360	COG0483	inositol monophosphate 1-phosphatase activity
IG195_03395	COG1132	(ABC) transporter
IG195_03400	COG0488	(ABC) transporter
IG195_03415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG195_03420	COG0765	amino acid transport
IG195_03425	COG1126	abc transporter atp-binding protein
IG195_03445	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IG195_03455	COG0746	molybdenum cofactor guanylyltransferase activity
IG195_03470	COG3103	Sh3 type 3 domain protein
IG195_03470	COG1388	LysM domain
IG195_03470	COG0791	NLP P60 protein
IG195_03475	COG0739	heme binding
IG195_03485	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IG195_03495	COG1278	Cold shock
IG195_03520	COG2132	Multicopper oxidase
IG195_03540	COG0745	RESPONSE REGULATOR receiver
IG195_03545	COG2205	protein histidine kinase activity
IG195_03555	COG0328	RNA-DNA hybrid ribonuclease activity
IG195_03560	COG0459	protein refolding
IG195_03580	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IG195_03605	COG0577	efflux transmembrane transporter activity
IG195_03605	COG1136	(ABC) transporter
IG195_03620	COG3591	Belongs to the peptidase S1B family
IG195_03620	COG1864	DNA RNA non-specific endonuclease
IG195_03625	COG1760	l-serine dehydratase
IG195_03630	COG0509	glycine decarboxylation via glycine cleavage system
IG195_03635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG195_03640	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IG195_03640	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IG195_03650	COG0477	Major facilitator Superfamily
IG195_03665	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IG195_03675	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IG195_03680	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IG195_03695	COG1338	Plays a role in the flagellum-specific transport system
IG195_03715	COG1360	Flagellar Motor Protein
IG195_03720	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IG195_03735	COG3550	peptidyl-serine autophosphorylation
IG195_03755	COG0791	NLP P60 protein
IG195_03765	COG1157	protein secretion by the type III secretion system
IG195_03775	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IG195_03780	COG1766	The M ring may be actively involved in energy transduction
IG195_03785	COG1677	Flagellar hook-basal body complex protein FliE
IG195_03795	COG1815	bacterial-type flagellum-dependent cell motility
IG195_03825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IG195_03835	COG4786	Flagellar basal body rod
IG195_03835	COG1256	bacterial-type flagellum assembly
IG195_03845	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
IG195_03860	COG1609	Transcriptional regulator
IG195_03870	COG0492	ferredoxin-NADP+ reductase activity
IG195_03885	COG2957	Belongs to the agmatine deiminase family
IG195_03910	COG0579	oxidoreductase
IG195_03950	COG1252	NADH dehydrogenase
IG195_03960	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IG195_03975	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_03980	COG0475	glutathione-regulated potassium exporter activity
IG195_04010	COG3842	ATPase activity
IG195_04040	COG0277	FAD linked oxidase domain protein
IG195_04070	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IG195_04080	COG0366	Alpha amylase catalytic
IG195_04125	COG0215	cysteine-tRNA ligase activity
IG195_04135	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IG195_04140	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IG195_04160	COG5002	protein histidine kinase activity
IG195_04170	COG0588	phosphoglycerate mutase activity
IG195_04190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IG195_04195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IG195_04235	COG1012	belongs to the aldehyde dehydrogenase family
IG195_04245	COG3547	Transposase (IS116 IS110 IS902 family)
IG195_04255	COG0656	L-ascorbic acid biosynthetic process
IG195_04275	COG1966	Carbon starvation protein
IG195_04285	COG0604	alcohol dehydrogenase
IG195_04285	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_04285	COG3321	synthase
IG195_04300	COG1113	amino acid transport
IG195_04310	COG1505	serine-type exopeptidase activity
IG195_04325	COG0514	ATP-dependent DNA helicase (RecQ)
IG195_04330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IG195_04345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IG195_04345	COG1017	nitric oxide dioxygenase activity
IG195_04350	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IG195_04375	COG0747	negative chemotaxis
IG195_04380	COG0601	transmembrane transport
IG195_04385	COG0444	Belongs to the ABC transporter superfamily
IG195_04390	COG4608	Belongs to the ABC transporter superfamily
IG195_04395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG195_04400	COG1940	carbohydrate kinase activity
IG195_04405	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
IG195_04415	COG1129	ABC transporter
IG195_04420	COG1511	domain protein
IG195_04425	COG1309	transcriptional regulator
IG195_04435	COG0697	spore germination
IG195_04440	COG0583	DNA-binding transcription factor activity
IG195_04445	COG2062	phosphohistidine phosphatase, SixA
IG195_04475	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IG195_04485	COG0438	transferase activity, transferring glycosyl groups
IG195_04555	COG1201	RNA secondary structure unwinding
IG195_04560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IG195_04565	COG2364	Membrane
IG195_04570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG195_04585	COG0564	pseudouridine synthase activity
IG195_04595	COG0586	Pfam SNARE associated Golgi protein
IG195_04605	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IG195_04630	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IG195_04655	COG1960	acyl-CoA dehydrogenase activity
IG195_04680	COG3842	ATPase activity
IG195_04695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG195_04700	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IG195_04705	COG1012	belongs to the aldehyde dehydrogenase family
IG195_04710	COG0028	Belongs to the TPP enzyme family
IG195_04715	COG0477	Major facilitator Superfamily
IG195_04720	COG2508	Transcriptional regulator
IG195_04725	COG0477	Major facilitator Superfamily
IG195_04735	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IG195_04755	COG0343	queuine tRNA-ribosyltransferase activity
IG195_04765	COG1309	transcriptional regulator
IG195_04770	COG1090	epimerase
IG195_04780	COG0477	Major facilitator Superfamily
IG195_04785	COG0745	RESPONSE REGULATOR receiver
IG195_04790	COG0642	Histidine kinase
IG195_04800	COG0351	phosphomethylpyrimidine kinase
IG195_04810	COG1309	transcriptional regulator
IG195_04815	COG1476	TRANSCRIPTIONal
IG195_04825	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IG195_04845	COG0673	inositol 2-dehydrogenase activity
IG195_04850	COG2182	Extracellular solute-binding protein
IG195_04855	COG1175	transmembrane transport
IG195_04860	COG0395	ABC-type sugar transport system, permease component
IG195_04880	COG2855	membrane
IG195_04890	COG4565	transcriptional regulatory protein
IG195_04895	COG3290	protein histidine kinase activity
IG195_04915	COG0589	response to stress
IG195_04930	COG0438	transferase activity, transferring glycosyl groups
IG195_04945	COG0395	ABC-type sugar transport system, permease component
IG195_04950	COG1175	transmembrane transport
IG195_04960	COG1609	Transcriptional regulator
IG195_04965	COG1309	transcriptional regulator
IG195_04995	COG1196	nuclear chromosome segregation
IG195_04995	COG0739	heme binding
IG195_04995	COG0741	lytic transglycosylase activity
IG195_05005	COG1012	belongs to the aldehyde dehydrogenase family
IG195_05020	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IG195_05035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IG195_05065	COG5416	Lipopolysaccharide assembly protein A domain
IG195_05080	COG1846	Transcriptional regulator
IG195_05110	COG1404	Belongs to the peptidase S8 family
IG195_05120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IG195_05140	COG0047	phosphoribosylformylglycinamidine synthase activity
IG195_05145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IG195_05160	COG3706	GGDEF domain
IG195_05175	COG0395	ABC-type sugar transport system, permease component
IG195_05180	COG1175	transmembrane transport
IG195_05185	COG1653	transport
IG195_05190	COG2315	Protein conserved in bacteria
IG195_05200	COG1832	CoA-binding protein
IG195_05220	COG1609	Transcriptional regulator
IG195_05225	COG0395	ABC-type sugar transport system, permease component
IG195_05230	COG1175	transmembrane transport
IG195_05245	COG1621	beta-fructofuranosidase activity
IG195_05255	COG3321	synthase
IG195_05255	COG0604	alcohol dehydrogenase
IG195_05255	COG4221	oxidoreductase activity
IG195_05255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IG195_05260	COG0129	dihydroxy-acid dehydratase activity
IG195_05270	COG2271	Major facilitator Superfamily
IG195_05295	COG0477	Major facilitator Superfamily
IG195_05300	COG1609	Transcriptional regulator
IG195_05310	COG0765	amino acid transport
IG195_05320	COG0673	inositol 2-dehydrogenase activity
IG195_05325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG195_05355	COG2814	Major facilitator Superfamily
IG195_05365	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IG195_05390	COG0357	Ribosomal RNA small subunit methyltransferase G
IG195_05390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IG195_05420	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IG195_05430	COG4948	Mandelate Racemase Muconate Lactonizing
IG195_05440	COG0246	Mannitol dehydrogenase
IG195_05445	COG1904	glucuronate isomerase
IG195_05450	COG1609	Transcriptional regulator
IG195_05455	COG0673	inositol 2-dehydrogenase activity
IG195_05470	COG0444	Belongs to the ABC transporter superfamily
IG195_05480	COG0747	negative chemotaxis
IG195_05495	COG1609	Transcriptional regulator
IG195_05510	COG0789	Transcriptional regulator
IG195_05525	COG3328	transposase activity
IG195_05535	COG1960	acyl-CoA dehydrogenase activity
IG195_05540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IG195_05575	COG1024	Enoyl-CoA hydratase
IG195_05585	COG0415	Belongs to the DNA photolyase family
IG195_05610	COG0583	DNA-binding transcription factor activity
IG195_05620	COG1473	amidohydrolase
IG195_05630	COG0174	glutamine synthetase
IG195_05635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG195_05670	COG1802	Transcriptional regulator
IG195_05685	COG3404	Formiminotransferase-cyclodeaminase
IG195_05690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IG195_05705	COG1063	alcohol dehydrogenase
IG195_05710	COG0303	'Molybdopterin
IG195_05715	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IG195_05725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IG195_05750	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IG195_05765	COG0666	response to abiotic stimulus
IG195_05775	COG4585	Histidine kinase
IG195_05780	COG2197	response regulator
IG195_05800	COG1609	Transcriptional regulator
IG195_05820	COG2182	Extracellular solute-binding protein
IG195_05885	COG1285	pathogenesis
IG195_05890	COG1175	transmembrane transport
IG195_05895	COG0395	ABC-type sugar transport system, permease component
IG195_05905	COG1802	Transcriptional regulator
IG195_05945	COG1609	Transcriptional regulator
IG195_05960	COG3848	Pyruvate phosphate dikinase
IG195_05960	COG0574	Belongs to the PEP-utilizing enzyme family
IG195_05985	COG2252	PERMEase
IG195_05990	COG0010	Belongs to the arginase family
IG195_06000	COG2902	Dehydrogenase
IG195_06020	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IG195_06040	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_06065	COG4122	O-methyltransferase activity
IG195_06100	COG2733	membrane
IG195_06105	COG1984	allophanate hydrolase subunit 2
IG195_06110	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IG195_06125	COG1609	Transcriptional regulator
IG195_06135	COG2828	Protein conserved in bacteria
IG195_06145	COG0673	inositol 2-dehydrogenase activity
IG195_06155	COG0673	inositol 2-dehydrogenase activity
IG195_06160	COG0673	inositol 2-dehydrogenase activity
IG195_06170	COG0028	Belongs to the TPP enzyme family
IG195_06175	COG0477	Major facilitator Superfamily
IG195_06200	COG2301	Belongs to the HpcH HpaI aldolase family
IG195_06205	COG4770	biotin carboxylase activity
IG195_06215	COG0318	PFAM AMP-dependent synthetase and ligase
IG195_06225	COG1902	pentaerythritol trinitrate reductase activity
IG195_06230	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_06235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG195_06245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IG195_06265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG195_06280	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG195_06310	COG3971	2-oxopent-4-enoate hydratase activity
IG195_06315	COG1414	Transcriptional regulator
IG195_06325	COG3384	dioxygenase
IG195_06330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG195_06340	COG3842	ATPase activity
IG195_06355	COG1846	Transcriptional regulator
IG195_06360	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IG195_06365	COG0142	geranyltranstransferase activity
IG195_06390	COG1846	Transcriptional regulator
IG195_06420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IG195_06425	COG1609	Transcriptional regulator
IG195_06430	COG3547	Transposase (IS116 IS110 IS902 family)
IG195_06450	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IG195_06475	COG1349	DNA-binding transcription factor activity
IG195_06485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IG195_06485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IG195_06485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IG195_06525	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IG195_06545	COG2890	protein-(glutamine-N5) methyltransferase activity
IG195_06550	COG0477	Major facilitator Superfamily
IG195_06565	COG4948	Mandelate Racemase Muconate Lactonizing
IG195_06575	COG1175	transmembrane transport
IG195_06585	COG2186	Transcriptional regulator
IG195_06590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG195_06595	COG0697	spore germination
IG195_06630	COG3486	L-lysine 6-monooxygenase (NADPH) activity
IG195_06685	COG2610	gluconate transmembrane transporter activity
IG195_06690	COG2084	Dehydrogenase
IG195_06705	COG2186	Transcriptional regulator
IG195_06730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IG195_06740	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IG195_06750	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_06755	COG3360	Dodecin
IG195_06770	COG0667	Aldo Keto reductase
IG195_06780	COG0656	L-ascorbic acid biosynthetic process
IG195_06785	COG2706	6-phosphogluconolactonase activity
IG195_06805	COG1595	DNA-templated transcription, initiation
IG195_06810	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IG195_06815	COG0829	nickel cation binding
IG195_06820	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IG195_06825	COG0830	nickel cation binding
IG195_06830	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IG195_06835	COG0804	urea catabolic process
IG195_06840	COG0832	Belongs to the urease beta subunit family
IG195_06845	COG0831	urea catabolic process
IG195_06895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IG195_06920	COG0671	phosphoesterase, PA-phosphatase related
IG195_06930	COG0492	ferredoxin-NADP+ reductase activity
IG195_06935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IG195_06955	COG1247	-acetyltransferase
IG195_06980	COG3559	Exporter of polyketide antibiotics
IG195_06985	COG1131	(ABC) transporter
IG195_06990	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IG195_07000	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
IG195_07040	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_07055	COG3237	CsbD-like
IG195_07060	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
IG195_07065	COG1461	Dihydroxyacetone kinase
IG195_07070	COG2376	Dihydroxyacetone kinase
IG195_07085	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IG195_07090	COG0823	Involved in the tonB-independent uptake of proteins
IG195_07090	COG1506	peptidase
IG195_07115	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IG195_07155	COG0477	Major facilitator Superfamily
IG195_07190	COG2814	Major facilitator Superfamily
IG195_07195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IG195_07225	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IG195_07235	COG0302	gtp cyclohydrolase
IG195_07240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IG195_07255	COG0037	tRNA processing
IG195_07265	COG2027	D-alanyl-D-alanine carboxypeptidase
IG195_07320	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IG195_07320	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IG195_07335	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IG195_07335	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IG195_07340	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IG195_07345	COG0438	transferase activity, transferring glycosyl groups
IG195_07355	COG0859	PFAM glycosyl transferase family 9
IG195_07360	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IG195_07365	COG0859	PFAM glycosyl transferase family 9
IG195_07370	COG1191	sigma factor activity
IG195_07390	COG0561	phosphatase activity
IG195_07395	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IG195_07400	COG1597	lipid kinase activity
IG195_07410	COG0077	Prephenate dehydratase
IG195_07415	COG0425	Belongs to the sulfur carrier protein TusA family
IG195_07415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IG195_07420	COG3340	Belongs to the peptidase S51 family
IG195_07430	COG3104	oligopeptide transport
IG195_07445	COG0778	Nitroreductase
IG195_07450	COG3415	Transposase
IG195_07450	COG2801	Transposase and inactivated derivatives
IG195_07455	COG2233	PERMEase
IG195_07465	COG3655	Transcriptional regulator
IG195_07475	COG0693	protein deglycase activity
IG195_07485	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IG195_07495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG195_07505	COG1929	Belongs to the glycerate kinase type-1 family
IG195_07510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IG195_07515	COG3250	beta-galactosidase activity
IG195_07520	COG0584	glycerophosphoryl diester phosphodiesterase
IG195_07530	COG0561	phosphatase activity
IG195_07535	COG0435	Glutathione S-transferase
IG195_07555	COG0659	secondary active sulfate transmembrane transporter activity
IG195_07560	COG0277	FAD linked oxidase domain protein
IG195_07565	COG4770	biotin carboxylase activity
IG195_07570	COG1984	allophanate hydrolase subunit 2
IG195_07575	COG0477	Major facilitator Superfamily
IG195_07580	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IG195_07585	COG2186	Transcriptional regulator
IG195_07600	COG0346	lactoylglutathione lyase activity
IG195_07650	COG1716	ATPase activity
IG195_07655	COG1716	ATPase activity
IG195_07670	COG0768	penicillin binding
IG195_07675	COG0515	serine threonine protein kinase
IG195_07680	COG0515	serine threonine protein kinase
IG195_07695	COG3764	Sortase (surface protein transpeptidase)
IG195_07710	COG1595	DNA-templated transcription, initiation
IG195_07715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IG195_07715	COG2169	Transcriptional regulator
IG195_07725	COG2818	Glycosylase
IG195_07735	COG0457	Tetratricopeptide repeat
IG195_07735	COG0705	Rhomboid family
IG195_07750	COG1215	transferase activity, transferring glycosyl groups
IG195_07760	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IG195_07760	COG3291	Pkd domain containing protein
IG195_07775	COG3266	domain, Protein
IG195_07780	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IG195_07785	COG0187	DNA topoisomerase II activity
IG195_07790	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
IG195_07795	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IG195_07800	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IG195_07805	COG0592	DNA-directed DNA polymerase activity
IG195_07810	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IG195_07815	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IG195_07820	COG0594	ribonuclease P activity
IG195_07825	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IG195_07830	COG0706	membrane insertase activity
IG195_07840	COG0357	Ribosomal RNA small subunit methyltransferase G
IG195_07845	COG1192	Involved in chromosome partitioning
IG195_07855	COG3118	belongs to the thioredoxin family
IG195_07860	COG0492	ferredoxin-NADP+ reductase activity
IG195_07880	COG0617	tRNA 3'-terminal CCA addition
IG195_07885	COG0406	alpha-ribazole phosphatase activity
IG195_07905	COG2910	NAD(P)H-binding
IG195_07910	COG1733	regulation of RNA biosynthetic process
IG195_07915	COG1136	(ABC) transporter
IG195_07925	COG4585	Histidine kinase
IG195_07930	COG2197	response regulator
IG195_07935	COG0768	penicillin binding
IG195_07945	COG0488	(ABC) transporter
IG195_07950	COG2801	Transposase and inactivated derivatives
IG195_07950	COG3415	Transposase
IG195_07960	COG0738	Major facilitator superfamily
IG195_07970	COG1597	lipid kinase activity
IG195_07975	COG1131	(ABC) transporter
IG195_07985	COG4585	Histidine kinase
IG195_07990	COG2197	response regulator
IG195_07995	COG1362	aminopeptidase activity
IG195_08000	COG1113	amino acid transport
IG195_08010	COG0640	Transcriptional regulator
IG195_08025	COG1742	UPF0060 membrane protein
IG195_08030	COG0360	Binds together with S18 to 16S ribosomal RNA
IG195_08040	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IG195_08045	COG0359	binds to the 23S rRNA
IG195_08100	COG0305	Participates in initiation and elongation during chromosome replication
IG195_08115	COG0698	ribose 5-phosphate isomerase
IG195_08120	COG2376	Dihydroxyacetone kinase
IG195_08125	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_08130	COG1082	Xylose isomerase domain protein TIM barrel
IG195_08140	COG3959	Transketolase, thiamine diphosphate binding domain
IG195_08145	COG3958	Transketolase
IG195_08160	COG1607	acyl-coa hydrolase
IG195_08215	COG1937	Protein conserved in bacteria
IG195_08275	COG2610	gluconate transmembrane transporter activity
IG195_08305	COG0583	DNA-binding transcription factor activity
IG195_08315	COG3384	dioxygenase
IG195_08325	COG3971	2-oxopent-4-enoate hydratase activity
IG195_08340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG195_08345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG195_08345	COG1116	anion transmembrane transporter activity
IG195_08350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG195_08355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG195_08360	COG1116	anion transmembrane transporter activity
IG195_08365	COG1309	transcriptional regulator
IG195_08390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG195_08425	COG0800	Aldolase
IG195_08430	COG2186	Transcriptional regulator
IG195_08440	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG195_08445	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG195_08460	COG2376	Dihydroxyacetone kinase
IG195_08465	COG1461	Dihydroxyacetone kinase
IG195_08470	COG0693	protein deglycase activity
IG195_08485	COG4948	Mandelate Racemase Muconate Lactonizing
IG195_08490	COG3386	PFAM SMP-30 Gluconolaconase
IG195_08495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IG195_08500	COG0693	protein deglycase activity
IG195_08515	COG1129	ABC transporter
IG195_08520	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG195_08525	COG4211	Belongs to the binding-protein-dependent transport system permease family
IG195_08560	COG1929	Belongs to the glycerate kinase type-1 family
IG195_08575	COG2259	Doxx family
IG195_08585	COG3547	Transposase (IS116 IS110 IS902 family)
IG195_08600	COG3845	ABC transporter
IG195_08610	COG3842	ATPase activity
IG195_08615	COG4149	molybdate abc transporter
IG195_08620	COG1177	transmembrane transport
IG195_08630	COG0646	methionine synthase
IG195_08630	COG1410	methionine synthase
IG195_08640	COG1136	(ABC) transporter
IG195_08640	COG0577	efflux transmembrane transporter activity
IG195_08680	COG0477	Major facilitator Superfamily
IG195_08685	COG1414	Transcriptional regulator
IG195_08690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IG195_08695	COG1082	Xylose isomerase domain protein TIM barrel
IG195_08695	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IG195_08700	COG3485	protocatechuate 3,4-dioxygenase
IG195_08705	COG3485	protocatechuate 3,4-dioxygenase
IG195_08720	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IG195_08725	COG0183	Belongs to the thiolase family
IG195_08735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IG195_08740	COG1414	Transcriptional regulator
IG195_08765	COG0546	phosphoglycolate phosphatase activity
IG195_08805	COG3328	transposase activity
IG195_08890	COG1802	Transcriptional regulator
IG195_08895	COG2271	Major facilitator Superfamily
IG195_08900	COG1970	mechanosensitive ion channel activity
IG195_08905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IG195_08910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IG195_08910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IG195_08915	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG195_08920	COG0509	glycine decarboxylation via glycine cleavage system
IG195_08925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IG195_08935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IG195_09035	COG1846	Transcriptional regulator
IG195_09040	COG0515	serine threonine protein kinase
IG195_09045	COG2261	transglycosylase associated protein
IG195_09060	COG0243	molybdopterin cofactor binding
IG195_09070	COG2814	Major facilitator Superfamily
IG195_09085	COG3387	PFAM Glycoside hydrolase 15-related
IG195_09115	COG2815	serine threonine protein kinase
IG195_09115	COG0515	serine threonine protein kinase
IG195_09130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG195_09135	COG1621	beta-fructofuranosidase activity
IG195_09140	COG1609	Transcriptional regulator
IG195_09145	COG0395	ABC-type sugar transport system, permease component
IG195_09155	COG1653	transport
IG195_09170	COG1621	beta-fructofuranosidase activity
IG195_09185	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_09195	COG2207	Transcriptional regulator
IG195_09195	COG3708	Transcriptional regulator
IG195_09205	COG2261	transglycosylase associated protein
IG195_09235	COG0436	Aminotransferase
IG195_09240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IG195_09250	COG0583	DNA-binding transcription factor activity
IG195_09255	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IG195_09260	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IG195_09265	COG1984	allophanate hydrolase subunit 2
IG195_09270	COG0477	Major facilitator Superfamily
IG195_09275	COG4221	oxidoreductase activity
IG195_09280	COG1607	acyl-coa hydrolase
IG195_09295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IG195_09310	COG1950	PFAM Membrane protein of
IG195_09315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IG195_09325	COG0022	dehydrogenase e1 component
IG195_09330	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG195_09370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG195_09400	COG1309	transcriptional regulator
IG195_09425	COG0673	inositol 2-dehydrogenase activity
IG195_09455	COG0686	Belongs to the AlaDH PNT family
IG195_09475	COG1793	dna ligase
IG195_09485	COG2267	carboxylic ester hydrolase activity
IG195_09505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IG195_09515	COG2213	PTS system mannitol-specific
IG195_09515	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IG195_09520	COG0246	Mannitol dehydrogenase
IG195_09530	COG1113	amino acid transport
IG195_09555	COG1846	Transcriptional regulator
IG195_09560	COG2814	Major facilitator Superfamily
IG195_09565	COG0477	Major facilitator Superfamily
IG195_09570	COG0477	Major facilitator Superfamily
IG195_09575	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IG195_09610	COG1309	transcriptional regulator
IG195_09615	COG0281	malic enzyme
IG195_09645	COG1760	l-serine dehydratase
IG195_09670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IG195_09680	COG0477	Major facilitator Superfamily
IG195_09690	COG1414	Transcriptional regulator
IG195_09715	COG1280	lysine exporter protein (LysE YggA)
IG195_09720	COG1522	sequence-specific DNA binding
IG195_09730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IG195_09735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IG195_09740	COG4221	oxidoreductase activity
IG195_09745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IG195_09755	COG2186	Transcriptional regulator
IG195_09765	COG1027	Aspartate ammonia-lyase
IG195_09775	COG2186	Transcriptional regulator
IG195_09885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IG195_09910	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IG195_09915	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IG195_09970	COG0776	regulation of translation
IG195_09990	COG0433	COG0433 Predicted ATPase
IG195_10005	COG0765	amino acid transport
IG195_10010	COG1126	abc transporter atp-binding protein
IG195_10020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG195_10035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IG195_10045	COG1937	Protein conserved in bacteria
IG195_10065	COG2801	Transposase and inactivated derivatives
IG195_10065	COG3415	Transposase
IG195_10070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IG195_10080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG195_10100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG195_10105	COG3387	PFAM Glycoside hydrolase 15-related
IG195_10115	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IG195_10130	COG1070	Carbohydrate kinase
IG195_10135	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_10135	COG3347	Dehydrogenase
IG195_10140	COG4952	isomerase
IG195_10145	COG3254	rhamnose metabolic process
IG195_10150	COG1609	Transcriptional regulator
IG195_10155	COG2017	converts alpha-aldose to the beta-anomer
IG195_10160	COG2160	L-arabinose isomerase activity
IG195_10175	COG1609	Transcriptional regulator
IG195_10180	COG1070	Carbohydrate kinase
IG195_10185	COG2115	Belongs to the xylose isomerase family
IG195_10210	COG0673	inositol 2-dehydrogenase activity
IG195_10215	COG1609	Transcriptional regulator
IG195_10230	COG0583	DNA-binding transcription factor activity
IG195_10270	COG0717	Belongs to the dCTP deaminase family
IG195_10280	COG0475	glutathione-regulated potassium exporter activity
IG195_10295	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IG195_10295	COG2111	Na H antiporter
IG195_10300	COG1006	Multisubunit Na H antiporter MnhC subunit
IG195_10305	COG0651	ATP synthesis coupled electron transport
IG195_10315	COG2212	antiporter activity
IG195_10320	COG1320	monovalent cation:proton antiporter activity
IG195_10335	COG4721	ABC-type cobalt transport system, permease component
IG195_10340	COG1122	ATPase activity
IG195_10365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IG195_10375	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IG195_10405	COG2986	histidine ammonia-lyase
IG195_10415	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IG195_10420	COG0833	amino acid
IG195_10430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG195_10440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IG195_10445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG195_10450	COG0477	Major facilitator Superfamily
IG195_10455	COG1957	nucleoside hydrolase
IG195_10460	COG1609	Transcriptional regulator
IG195_10465	COG1280	lysine exporter protein (LysE YggA)
IG195_10490	COG0667	Aldo Keto reductase
IG195_10495	COG4941	Belongs to the sigma-70 factor family
IG195_10500	COG3795	YCII-related domain
IG195_10505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IG195_10515	COG2409	Drug exporters of the RND superfamily
IG195_10520	COG0492	ferredoxin-NADP+ reductase activity
IG195_10525	COG2026	Addiction module toxin, RelE StbE family
IG195_10530	COG2161	toxin-antitoxin pair type II binding
IG195_10540	COG1280	lysine exporter protein (LysE YggA)
IG195_10560	COG1064	alcohol dehydrogenase
IG195_10565	COG0436	Aminotransferase
IG195_10625	COG3540	Alkaline phosphatase
IG195_10635	COG0477	Major facilitator Superfamily
IG195_10665	COG3739	integral membrane protein
IG195_10670	COG0443	Heat shock 70 kDa protein
IG195_10675	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IG195_10680	COG0484	heat shock protein binding
IG195_10685	COG0789	Transcriptional regulator
IG195_10690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IG195_10695	COG1879	ABC-type sugar transport system periplasmic component
IG195_10700	COG1129	ABC transporter
IG195_10705	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG195_10710	COG1082	Xylose isomerase domain protein TIM barrel
IG195_10720	COG1737	Transcriptional regulator
IG195_10725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IG195_10730	COG2140	Oxalate decarboxylase
IG195_10740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IG195_10745	COG1063	alcohol dehydrogenase
IG195_10750	COG1063	alcohol dehydrogenase
IG195_10760	COG0800	Aldolase
IG195_10790	COG4221	oxidoreductase activity
IG195_10795	COG0477	Major facilitator Superfamily
IG195_10810	COG1105	Belongs to the carbohydrate kinase PfkB family
IG195_10815	COG3958	Transketolase
IG195_10820	COG3959	Transketolase, thiamine diphosphate binding domain
IG195_10825	COG1063	alcohol dehydrogenase
IG195_10870	COG3177	Filamentation induced by cAMP protein fic
IG195_10885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IG195_10920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IG195_10925	COG2807	transmembrane transport
IG195_10930	COG0477	Major facilitator Superfamily
IG195_10935	COG1473	amidohydrolase
IG195_10945	COG2813	Specifically methylates the guanine in position
IG195_10970	COG2076	Multidrug Resistance protein
IG195_10975	COG2076	Multidrug Resistance protein
IG195_10985	COG0135	phosphoribosylanthranilate isomerase activity
IG195_10995	COG3304	Inner membrane component domain
IG195_11015	COG3585	molybdate ion transport
IG195_11040	COG0542	response to heat
IG195_11075	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IG195_11100	COG0671	phosphoesterase, PA-phosphatase related
IG195_11105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IG195_11130	COG1366	Belongs to the anti-sigma-factor antagonist family
IG195_11140	COG0745	RESPONSE REGULATOR receiver
IG195_11155	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IG195_11160	COG1929	Belongs to the glycerate kinase type-1 family
IG195_11165	COG3960	tartronate-semialdehyde synthase activity
IG195_11170	COG2084	Dehydrogenase
IG195_11175	COG3622	Belongs to the hyi family
IG195_11200	COG1609	Transcriptional regulator
IG195_11205	COG1653	transport
IG195_11220	COG0673	inositol 2-dehydrogenase activity
IG195_11250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IG195_11300	COG0405	Gamma-glutamyltransferase
IG195_11395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IG195_11400	COG3311	Transcriptional regulator
IG195_11415	COG0300	oxidoreductase activity
IG195_11425	COG3401	FG-GAP repeat protein
IG195_11435	COG0563	adenylate kinase activity
IG195_11455	COG0659	secondary active sulfate transmembrane transporter activity
IG195_11480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IG195_11485	COG4585	Histidine kinase
IG195_11490	COG2318	DinB family
IG195_11505	COG3257	ureidoglycine aminohydrolase activity
IG195_11515	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IG195_11525	COG1414	Transcriptional regulator
IG195_11530	COG2233	PERMEase
IG195_11555	COG0590	tRNA wobble adenosine to inosine editing
IG195_11560	COG2252	PERMEase
IG195_11565	COG3608	succinylglutamate desuccinylase aspartoacylase
IG195_11565	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IG195_11575	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IG195_11595	COG1953	Uracil, thiamine, allantoin
IG195_11605	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_11625	COG0151	Belongs to the GarS family
IG195_11630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IG195_11650	COG1132	(ABC) transporter
IG195_11655	COG1132	(ABC) transporter
IG195_11660	COG1408	metallophosphoesterase
IG195_11665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IG195_11695	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IG195_11710	COG0395	ABC-type sugar transport system, permease component
IG195_11715	COG1175	transmembrane transport
IG195_11725	COG1609	Transcriptional regulator
IG195_11735	COG1136	(ABC) transporter
IG195_11735	COG0577	efflux transmembrane transporter activity
IG195_11740	COG1349	DNA-binding transcription factor activity
IG195_11745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IG195_11815	COG1111	helicase
IG195_11815	COG1205	dead DEAH box helicase
IG195_11825	COG1054	Belongs to the UPF0176 family
IG195_11840	COG2890	protein-(glutamine-N5) methyltransferase activity
IG195_11850	COG1754	DNA topoisomerase type I activity
IG195_11850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IG195_11865	COG1082	Xylose isomerase domain protein TIM barrel
IG195_11870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IG195_11875	COG0569	domain protein
IG195_11880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IG195_11885	COG0123	including yeast histone deacetylase and acetoin utilization protein
IG195_11895	COG0640	Transcriptional regulator
IG195_11900	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IG195_11915	COG1609	Transcriptional regulator
IG195_11920	COG0673	inositol 2-dehydrogenase activity
IG195_11930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG195_11935	COG4948	Mandelate Racemase Muconate Lactonizing
IG195_11960	COG1175	transmembrane transport
IG195_11965	COG0395	ABC-type sugar transport system, permease component
IG195_11985	COG1175	transmembrane transport
IG195_11990	COG0395	ABC-type sugar transport system, permease component
IG195_12000	COG2814	Major facilitator Superfamily
IG195_12015	COG1653	transport
IG195_12020	COG4209	transmembrane transport
IG195_12025	COG0395	ABC-type sugar transport system, permease component
IG195_12030	COG2755	lipolytic protein G-D-S-L family
IG195_12040	COG3458	cephalosporin-C deacetylase activity
IG195_12045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IG195_12095	COG0406	alpha-ribazole phosphatase activity
IG195_12105	COG0785	Cytochrome C biogenesis protein
IG195_12115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IG195_12120	COG0443	Heat shock 70 kDa protein
IG195_12170	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IG195_12180	COG1266	CAAX protease self-immunity
IG195_12185	COG0803	Belongs to the bacterial solute-binding protein 9 family
IG195_12190	COG1121	(ABC) transporter
IG195_12195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IG195_12200	COG0488	(ABC) transporter
IG195_12225	COG0183	Belongs to the thiolase family
IG195_12230	COG1024	Enoyl-CoA hydratase
IG195_12235	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG195_12250	COG1216	Glycosyl transferase, family 2
IG195_12255	COG1012	belongs to the aldehyde dehydrogenase family
IG195_12255	COG2030	dehydratase
IG195_12275	COG2050	protein possibly involved in aromatic compounds catabolism
IG195_12300	COG5002	protein histidine kinase activity
IG195_12320	COG2203	Gaf domain
IG195_12320	COG4251	negative regulation of phosphorylation
IG195_12320	COG3706	GGDEF domain
IG195_12320	COG5001	Diguanylate cyclase
IG195_12330	COG3979	chitinase
IG195_12335	COG0463	Glycosyl transferase, family 2
IG195_12340	COG3396	Phenylacetate-CoA oxygenase
IG195_12345	COG3460	Phenylacetate-CoA oxygenase
IG195_12350	COG3396	Phenylacetate-CoA oxygenase
IG195_12355	COG2151	metal-sulfur cluster biosynthetic enzyme
IG195_12360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IG195_12365	COG1024	Enoyl-CoA hydratase
IG195_12370	COG2184	nucleotidyltransferase activity
IG195_12375	COG1597	lipid kinase activity
IG195_12390	COG1316	TRANSCRIPTIONal
IG195_12415	COG1682	transport, permease protein
IG195_12420	COG1134	teichoic acid transport
IG195_12430	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IG195_12450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IG195_12455	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IG195_12470	COG0110	maltose O-acetyltransferase activity
IG195_12490	COG0022	dehydrogenase e1 component
IG195_12495	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG195_12500	COG1404	Belongs to the peptidase S8 family
IG195_12550	COG1175	transmembrane transport
IG195_12555	COG0395	ABC-type sugar transport system, permease component
IG195_12560	COG1621	beta-fructofuranosidase activity
IG195_12565	COG1609	Transcriptional regulator
IG195_12580	COG4948	Mandelate Racemase Muconate Lactonizing
IG195_12590	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IG195_12600	COG0765	amino acid transport
IG195_12610	COG1169	isochorismate synthase
IG195_12615	COG2226	methyltransferase
IG195_12625	COG0142	geranyltranstransferase activity
IG195_12640	COG2860	membrane
IG195_12650	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IG195_12655	COG0175	sulfate reduction
IG195_12665	COG2895	sulfate adenylyltransferase (ATP) activity
IG195_12670	COG2040	homocysteine
IG195_12680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG195_12680	COG1116	anion transmembrane transporter activity
IG195_12685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG195_12700	COG1733	regulation of RNA biosynthetic process
IG195_12710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG195_12720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IG195_12720	COG1648	precorrin-2 dehydrogenase activity
IG195_12730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IG195_12730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG195_12735	COG2186	Transcriptional regulator
IG195_12740	COG2807	transmembrane transport
IG195_12745	COG3835	regulator
IG195_12750	COG1012	belongs to the aldehyde dehydrogenase family
IG195_12785	COG0531	amino acid
IG195_12815	COG0501	Belongs to the peptidase M48B family
IG195_12820	COG1666	GTP binding
IG195_12835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IG195_12855	COG1131	(ABC) transporter
IG195_12870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IG195_12900	COG1051	belongs to the nudix hydrolase family
IG195_12920	COG0395	ABC-type sugar transport system, permease component
IG195_12925	COG1175	transmembrane transport
IG195_12945	COG0754	glutathionylspermidine amidase activity
IG195_12980	COG0702	epimerase
IG195_12990	COG1940	carbohydrate kinase activity
IG195_13000	COG1175	transmembrane transport
IG195_13005	COG0395	ABC-type sugar transport system, permease component
IG195_13010	COG0366	Alpha amylase catalytic
IG195_13015	COG4989	oxidoreductase activity
IG195_13025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG195_13050	COG2030	dehydratase
IG195_13060	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IG195_13075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IG195_13085	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IG195_13090	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IG195_13095	COG1725	Transcriptional regulator
IG195_13110	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IG195_13115	COG0456	acetyltransferase
IG195_13120	COG0745	RESPONSE REGULATOR receiver
IG195_13130	COG3485	protocatechuate 3,4-dioxygenase
IG195_13140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG195_13190	COG2197	response regulator
IG195_13195	COG0436	Aminotransferase
IG195_13205	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IG195_13215	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IG195_13220	COG0081	regulation of translation
IG195_13235	COG3415	Transposase
IG195_13235	COG2801	Transposase and inactivated derivatives
IG195_13240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IG195_13245	COG0222	ribosome binding
IG195_13250	COG0442	prolyl-tRNA aminoacylation
IG195_13255	COG0183	Belongs to the thiolase family
IG195_13260	COG0085	RNA polymerase activity
IG195_13265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IG195_13270	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IG195_13275	COG0049	tRNA binding
IG195_13280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IG195_13285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IG195_13295	COG2723	6-phospho-beta-galactosidase activity
IG195_13300	COG0051	transcription antitermination factor activity, RNA binding
IG195_13305	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IG195_13310	COG0088	Forms part of the polypeptide exit tunnel
IG195_13315	COG0089	rRNA binding
IG195_13320	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IG195_13325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IG195_13330	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IG195_13335	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IG195_13340	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IG195_13345	COG0255	Belongs to the universal ribosomal protein uL29 family
IG195_13350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IG195_13355	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IG195_13360	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IG195_13365	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IG195_13370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IG195_13375	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IG195_13385	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IG195_13390	COG1841	ribosomal large subunit assembly
IG195_13395	COG0200	Binds to the 23S rRNA
IG195_13405	COG0563	adenylate kinase activity
IG195_13410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IG195_13415	COG1216	Glycosyl transferase, family 2
IG195_13415	COG1442	glycosyl transferase family 8
IG195_13425	COG0318	PFAM AMP-dependent synthetase and ligase
IG195_13455	COG3191	aminopeptidase activity
IG195_13460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IG195_13465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IG195_13470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IG195_13475	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IG195_13480	COG0202	RNA polymerase activity
IG195_13485	COG0203	ribosomal protein L17
IG195_13490	COG0101	tRNA pseudouridine synthase activity
IG195_13510	COG0455	bacterial-type flagellum organization
IG195_13540	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IG195_13545	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IG195_13550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IG195_13555	COG1876	peptidase activity
IG195_13560	COG1072	(Pantothenic acid kinase))
IG195_13570	COG0736	holo-[acyl-carrier-protein] synthase activity
IG195_13595	COG0667	Aldo Keto reductase
IG195_13605	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IG195_13610	COG0438	transferase activity, transferring glycosyl groups
IG195_13620	COG1486	melibiose metabolic process
IG195_13630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IG195_13635	COG0802	atpase or kinase
IG195_13650	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IG195_13655	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IG195_13665	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IG195_13670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IG195_13685	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IG195_13690	COG0459	protein refolding
IG195_13710	COG1132	(ABC) transporter
IG195_13715	COG0516	GMP reductase activity
IG195_13735	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IG195_13755	COG0519	Catalyzes the synthesis of GMP from XMP
IG195_13755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IG195_13775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IG195_13780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IG195_13810	COG1695	Transcriptional regulator
IG195_13815	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IG195_13825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IG195_13830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IG195_13835	COG1528	Iron-storage protein
IG195_13840	COG0598	Magnesium transport protein CorA
IG195_13865	COG3548	integral membrane protein
IG195_13880	COG2971	BadF BadG BcrA BcrD
IG195_13895	COG1162	GTPase activity
IG195_13905	COG1174	glycine betaine transport
IG195_13925	COG2326	polyphosphate kinase activity
IG195_13930	COG1722	exodeoxyribonuclease VII activity
IG195_13935	COG1570	exodeoxyribonuclease VII activity
IG195_13945	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IG195_13950	COG1322	Protein conserved in bacteria
IG195_13955	COG0012	GTP binding
IG195_14035	COG0601	transmembrane transport
IG195_14040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG195_14055	COG1217	gtp-binding protein TYPA
IG195_14085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IG195_14090	COG3226	Transcriptional regulator
IG195_14105	COG2171	N-acyltransferase activity
IG195_14110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG195_14115	COG0765	amino acid transport
IG195_14120	COG0765	amino acid transport
IG195_14125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG195_14130	COG1126	abc transporter atp-binding protein
IG195_14155	COG4122	O-methyltransferase activity
IG195_14160	COG1595	DNA-templated transcription, initiation
IG195_14170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IG195_14185	COG2239	Acts as a magnesium transporter
IG195_14195	COG0006	proline dipeptidase activity
IG195_14200	COG0613	PHP domain protein
IG195_14205	COG2095	MarC family integral membrane protein
IG195_14215	COG0513	Belongs to the DEAD box helicase family
IG195_14230	COG0352	thiamine-phosphate diphosphorylase activity
IG195_14235	COG2022	thiamine diphosphate biosynthetic process
IG195_14235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG195_14260	COG1309	transcriptional regulator
IG195_14270	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IG195_14275	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IG195_14285	COG3253	May function as heme-dependent peroxidase
IG195_14290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IG195_14295	COG0181	hydroxymethylbilane synthase activity
IG195_14305	COG0113	porphobilinogen synthase activity
IG195_14315	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IG195_14320	COG1472	Belongs to the glycosyl hydrolase 3 family
IG195_14345	COG1074	ATP-dependent DNA helicase activity
IG195_14360	COG2816	NAD+ diphosphatase activity
IG195_14380	COG3480	Lon protease (S16) C-terminal proteolytic domain
IG195_14385	COG1615	UPF0182 protein
IG195_14405	COG1842	Phage shock protein A
IG195_14415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG195_14420	COG2086	electron transfer activity
IG195_14425	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IG195_14430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IG195_14435	COG3265	gluconokinase activity
IG195_14445	COG1595	DNA-templated transcription, initiation
IG195_14450	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IG195_14455	COG0484	heat shock protein binding
IG195_14485	COG0482	sulfurtransferase activity
IG195_14505	COG0601	transmembrane transport
IG195_14540	COG0714	Associated with various cellular activities
IG195_14560	COG0745	RESPONSE REGULATOR receiver
IG195_14570	COG5401	PFAM Sporulation and spore germination
IG195_14580	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IG195_14585	COG3214	Protein conserved in bacteria
IG195_14590	COG0653	protein targeting
IG195_14625	COG2902	Dehydrogenase
IG195_14645	COG1674	ftsk spoiiie
IG195_14655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IG195_14670	COG1216	Glycosyl transferase, family 2
IG195_14760	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IG195_14765	COG2884	Cell division ATP-binding protein ftsE
IG195_14770	COG2177	Part of the ABC transporter FtsEX involved in
IG195_14780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IG195_14815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IG195_14820	COG0483	inositol monophosphate 1-phosphatase activity
IG195_14830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IG195_14840	COG1595	DNA-templated transcription, initiation
IG195_14865	COG0567	Dehydrogenase, E1 component
IG195_14865	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG195_14870	COG1253	flavin adenine dinucleotide binding
IG195_14880	COG0803	Belongs to the bacterial solute-binding protein 9 family
IG195_14885	COG1121	(ABC) transporter
IG195_14890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IG195_14915	COG1064	alcohol dehydrogenase
IG195_14920	COG0537	adenosine 5'-monophosphoramidase activity
IG195_14925	COG1643	Atp-dependent helicase
IG195_14960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IG195_14960	COG1017	nitric oxide dioxygenase activity
IG195_14975	COG0018	arginyl-trna synthetase
IG195_14980	COG0019	diaminopimelate decarboxylase activity
IG195_14985	COG0460	homoserine dehydrogenase
IG195_14990	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IG195_14995	COG0083	homoserine kinase activity
IG195_15005	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IG195_15010	COG2890	protein-(glutamine-N5) methyltransferase activity
IG195_15015	COG0009	L-threonylcarbamoyladenylate synthase
IG195_15030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IG195_15045	COG0356	it plays a direct role in the translocation of protons across the membrane
IG195_15050	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IG195_15055	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IG195_15060	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IG195_15065	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IG195_15070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IG195_15075	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IG195_15080	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IG195_15090	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IG195_15095	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IG195_15105	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IG195_15110	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
IG195_15140	COG1902	pentaerythritol trinitrate reductase activity
IG195_15155	COG0363	glucosamine-6-phosphate deaminase activity
IG195_15170	COG1335	isochorismatase
IG195_15180	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IG195_15190	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IG195_15195	COG1234	tRNA 3'-trailer cleavage
IG195_15200	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IG195_15205	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IG195_15220	COG1131	(ABC) transporter
IG195_15245	COG2149	membrane
IG195_15260	COG0420	3'-5' exonuclease activity
IG195_15265	COG0419	ATPase involved in DNA repair
IG195_15275	COG1414	Transcriptional regulator
IG195_15280	COG0477	Major facilitator Superfamily
IG195_15300	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG195_15305	COG0022	dehydrogenase e1 component
IG195_15315	COG1113	amino acid transport
IG195_15320	COG1522	sequence-specific DNA binding
IG195_15330	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IG195_15335	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IG195_15345	COG1104	cysteine desulfurase activity
IG195_15360	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IG195_15370	COG1305	Transglutaminase-like
IG195_15375	COG1846	Transcriptional regulator
IG195_15380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG195_15385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IG195_15390	COG0579	oxidoreductase
IG195_15395	COG0747	negative chemotaxis
IG195_15425	COG2133	pyrroloquinoline quinone binding
IG195_15435	COG0129	dihydroxy-acid dehydratase activity
IG195_15445	COG0440	acetolactate synthase activity
IG195_15450	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IG195_15455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IG195_15465	COG0577	efflux transmembrane transporter activity
IG195_15465	COG1136	(ABC) transporter
IG195_15480	COG0577	efflux transmembrane transporter activity
IG195_15480	COG1136	(ABC) transporter
IG195_15485	COG2197	response regulator
IG195_15490	COG4585	Histidine kinase
IG195_15495	COG0473	3-isopropylmalate dehydrogenase activity
IG195_15500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IG195_15505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG195_15515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IG195_15550	COG1414	Transcriptional regulator
IG195_15555	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IG195_15560	COG0066	3-isopropylmalate dehydratase activity
IG195_15565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IG195_15575	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IG195_15580	COG1181	Belongs to the D-alanine--D-alanine ligase family
IG195_15595	COG1461	Dihydroxyacetone kinase
IG195_15605	COG0742	ribosomal rna small subunit methyltransferase
IG195_15620	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IG195_15630	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IG195_15635	COG0571	ribonuclease III activity
IG195_15640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IG195_15680	COG2814	Major facilitator Superfamily
IG195_15695	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IG195_15720	COG2514	catechol 2,3-dioxygenase activity
IG195_15730	COG0228	four-way junction DNA binding
IG195_15735	COG1837	Belongs to the UPF0109 family
IG195_15740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IG195_15745	COG0336	Belongs to the RNA methyltransferase TrmD family
IG195_15750	COG0335	large ribosomal subunit rRNA binding
IG195_15755	COG0681	Belongs to the peptidase S26 family
IG195_15765	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IG195_15775	COG0792	nuclease activity
IG195_15785	COG1473	amidohydrolase
IG195_15795	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IG195_15800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IG195_15815	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IG195_15825	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_15830	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IG195_15835	COG2124	cytochrome p450
IG195_15855	COG0512	Glutamine amidotransferase of anthranilate synthase
IG195_15875	COG0686	Belongs to the AlaDH PNT family
IG195_15890	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IG195_15915	COG2149	membrane
IG195_15935	COG2814	Major facilitator Superfamily
IG195_15950	COG0456	acetyltransferase
IG195_15975	COG4974	Belongs to the 'phage' integrase family
IG195_15990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IG195_15995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IG195_16010	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IG195_16035	COG2801	Transposase and inactivated derivatives
IG195_16035	COG3415	Transposase
IG195_16050	COG0477	Major facilitator Superfamily
IG195_16060	COG2084	Dehydrogenase
IG195_16065	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_16070	COG1063	alcohol dehydrogenase
IG195_16080	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IG195_16085	COG1045	serine acetyltransferase
IG195_16095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IG195_16100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IG195_16110	COG3022	response to hydroperoxide
IG195_16140	COG0242	peptide deformylase activity
IG195_16165	COG0629	single-stranded DNA binding
IG195_16185	COG1946	Acyl-CoA thioesterase
IG195_16200	COG0668	transmembrane transport
IG195_16245	COG0544	peptidyl-prolyl cis-trans isomerase activity
IG195_16250	COG0740	serine-type endopeptidase activity
IG195_16255	COG0740	serine-type endopeptidase activity
IG195_16260	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IG195_16265	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IG195_16270	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IG195_16275	COG0525	valine-tRNA ligase activity
IG195_16290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IG195_16295	COG0285	dihydrofolate synthase activity
IG195_16305	COG0105	UTP biosynthetic process
IG195_16315	COG1530	ribonuclease E activity
IG195_16320	COG0351	phosphomethylpyrimidine kinase
IG195_16320	COG0352	thiamine-phosphate diphosphorylase activity
IG195_16320	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IG195_16325	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IG195_16330	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IG195_16335	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IG195_16340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IG195_16345	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IG195_16355	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IG195_16365	COG0799	negative regulation of ribosome biogenesis
IG195_16385	COG2813	Specifically methylates the guanine in position
IG195_16400	COG0714	Associated with various cellular activities
IG195_16440	COG0583	DNA-binding transcription factor activity
IG195_16450	COG1780	Probably involved in ribonucleotide reductase function
IG195_16455	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IG195_16465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IG195_16485	COG4804	nuclease activity
IG195_16520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG195_16535	COG2135	peptidase activity
IG195_16560	COG0587	DNA-directed DNA polymerase activity
IG195_16565	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IG195_16575	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IG195_16580	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IG195_16585	COG0339	signal peptide processing
IG195_16605	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IG195_16610	COG0217	transcriptional regulatory protein
IG195_16615	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IG195_16620	COG0632	four-way junction helicase activity
IG195_16625	COG2255	four-way junction helicase activity
IG195_16635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IG195_16640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IG195_16645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IG195_16655	COG1196	nuclear chromosome segregation
IG195_16665	COG0124	histidyl-tRNA synthetase
IG195_16670	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IG195_16690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IG195_16705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IG195_16720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IG195_16725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IG195_16730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IG195_16735	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IG195_16745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IG195_16750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IG195_16760	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IG195_16765	COG0540	Belongs to the ATCase OTCase family
IG195_16770	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IG195_16780	COG0505	Belongs to the CarA family
IG195_16785	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IG195_16790	COG0284	orotidine-5'-phosphate decarboxylase activity
IG195_16800	COG0194	GDP metabolic process
IG195_16805	COG1758	RNA polymerase activity
IG195_16815	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IG195_16830	COG0438	transferase activity, transferring glycosyl groups
IG195_16840	COG0656	L-ascorbic acid biosynthetic process
IG195_16845	COG2390	Transcriptional regulator
IG195_16850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IG195_16855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IG195_16860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IG195_16865	COG0495	leucyl-tRNA aminoacylation
IG195_16870	COG1307	EDD domain protein, DegV family
IG195_16890	COG0268	Binds directly to 16S ribosomal RNA
IG195_16900	COG0481	GTPase activity
IG195_16920	COG1420	regulation of RNA biosynthetic process
IG195_16925	COG0484	heat shock protein binding
IG195_16945	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IG195_16955	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IG195_16960	COG1316	TRANSCRIPTIONal
IG195_16965	COG3590	peptidase
IG195_16970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IG195_16975	COG1381	Involved in DNA repair and RecF pathway recombination
IG195_16980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IG195_16985	COG2267	carboxylic ester hydrolase activity
IG195_17000	COG0167	dihydroorotate dehydrogenase activity
IG195_17020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IG195_17025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IG195_17035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IG195_17040	COG2186	Transcriptional regulator
IG195_17045	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IG195_17050	COG0723	plastoquinol--plastocyanin reductase activity
IG195_17055	COG2010	Cytochrome c
IG195_17060	COG1845	cytochrome c oxidase, subunit III
IG195_17065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IG195_17120	COG1126	abc transporter atp-binding protein
IG195_17130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG195_17135	COG2188	Transcriptional regulator
IG195_17170	COG0667	Aldo Keto reductase
IG195_17180	COG3424	synthase
IG195_17185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IG195_17200	COG0242	peptide deformylase activity
IG195_17205	COG4946	Tricorn protease homolog
IG195_17205	COG1506	peptidase
IG195_17205	COG0823	Involved in the tonB-independent uptake of proteins
IG195_17210	COG2226	methyltransferase
IG195_17230	COG1216	Glycosyl transferase, family 2
IG195_17235	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IG195_17240	COG4581	dead DEAH box helicase
IG195_17245	COG0805	protein transport
IG195_17250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IG195_17265	COG0545	Peptidyl-prolyl cis-trans isomerase
IG195_17270	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IG195_17275	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IG195_17280	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IG195_17290	COG4122	O-methyltransferase activity
IG195_17295	COG1222	aaa ATPase
IG195_17310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IG195_17320	COG0215	cysteine-tRNA ligase activity
IG195_17325	COG1968	undecaprenyl-diphosphatase activity
IG195_17330	COG0656	L-ascorbic acid biosynthetic process
IG195_17335	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IG195_17340	COG1088	dTDP-glucose 4,6-dehydratase activity
IG195_17415	COG0673	inositol 2-dehydrogenase activity
IG195_17420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IG195_17455	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_17460	COG0183	Belongs to the thiolase family
IG195_17470	COG1960	acyl-CoA dehydrogenase activity
IG195_17475	COG0297	glycogen (starch) synthase activity
IG195_17480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IG195_17490	COG1305	Transglutaminase-like
IG195_17515	COG0254	rRNA binding
IG195_17530	COG1119	ATPase activity
IG195_17535	COG3830	Belongs to the UPF0237 family
IG195_17535	COG0560	Phosphoserine phosphatase
IG195_17545	COG1129	ABC transporter
IG195_17550	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_17555	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_17580	COG0488	(ABC) transporter
IG195_17585	COG1268	BioY protein
IG195_17590	COG1122	ATPase activity
IG195_17605	COG0318	PFAM AMP-dependent synthetase and ligase
IG195_17615	COG2151	metal-sulfur cluster biosynthetic enzyme
IG195_17620	COG0396	ATPase activity
IG195_17645	COG1131	(ABC) transporter
IG195_17655	COG1612	heme a metabolic process
IG195_17660	COG0109	protoheme IX farnesyltransferase activity
IG195_17670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IG195_17675	COG0166	Belongs to the GPI family
IG195_17690	COG0363	glucosamine-6-phosphate deaminase activity
IG195_17700	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IG195_17705	COG0149	triose-phosphate isomerase activity
IG195_17710	COG0126	phosphoglycerate kinase activity
IG195_17715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IG195_17720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IG195_17725	COG1481	regulation of sporulation
IG195_17735	COG1660	Displays ATPase and GTPase activities
IG195_17740	COG0322	excinuclease ABC activity
IG195_17750	COG0546	phosphoglycolate phosphatase activity
IG195_17765	COG4106	trans-aconitate 2-methyltransferase activity
IG195_17775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG195_17800	COG0556	nucleotide-excision repair
IG195_17805	COG0237	dephospho-CoA kinase activity
IG195_17805	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IG195_17810	COG1739	Uncharacterized protein family UPF0029
IG195_17815	COG0539	negative regulation of cytoplasmic translation
IG195_17820	COG4552	Acetyltransferase involved in intracellular survival and related
IG195_17830	COG2050	protein possibly involved in aromatic compounds catabolism
IG195_17865	COG3483	tryptophan 2,3-dioxygenase activity
IG195_17880	COG2971	BadF BadG BcrA BcrD
IG195_17900	COG0009	L-threonylcarbamoyladenylate synthase
IG195_17930	COG1643	Atp-dependent helicase
IG195_17935	COG1064	alcohol dehydrogenase
IG195_17950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IG195_17975	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IG195_17990	COG3285	dna ligase
IG195_17990	COG1793	dna ligase
IG195_17995	COG0028	Belongs to the TPP enzyme family
IG195_18010	COG1802	Transcriptional regulator
IG195_18025	COG3971	2-oxopent-4-enoate hydratase activity
IG195_18060	COG2814	Major facilitator Superfamily
IG195_18085	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG195_18090	COG0251	oxidation-reduction process
IG195_18110	COG0572	uridine kinase
IG195_18160	COG2197	response regulator
IG195_18165	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
IG195_18170	COG1846	Transcriptional regulator
IG195_18205	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_18230	COG1012	belongs to the aldehyde dehydrogenase family
IG195_18235	COG3608	succinylglutamate desuccinylase aspartoacylase
IG195_18235	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IG195_18245	COG2080	2 iron, 2 sulfur cluster binding
IG195_18255	COG2175	clavaminate synthase activity
IG195_18260	COG0477	Major facilitator Superfamily
IG195_18280	COG3842	ATPase activity
IG195_18290	COG1228	amidohydrolase
IG195_18300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IG195_18305	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IG195_18335	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG195_18340	COG1129	ABC transporter
IG195_18345	COG0673	inositol 2-dehydrogenase activity
IG195_18355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IG195_18360	COG0129	dihydroxy-acid dehydratase activity
IG195_18365	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_18370	COG0673	inositol 2-dehydrogenase activity
IG195_18375	COG1012	belongs to the aldehyde dehydrogenase family
IG195_18380	COG3962	Belongs to the TPP enzyme family
IG195_18400	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG195_18405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IG195_18435	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IG195_18440	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IG195_18460	COG0280	phosphate acetyltransferase
IG195_18460	COG0857	belongs to the CobB CobQ family
IG195_18505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IG195_18535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IG195_18540	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG195_18545	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG195_18545	COG0022	dehydrogenase e1 component
IG195_18550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IG195_18585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IG195_18605	COG1937	Protein conserved in bacteria
IG195_18615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IG195_18615	COG0574	Belongs to the PEP-utilizing enzyme family
IG195_18635	COG1131	(ABC) transporter
IG195_18650	COG0726	polysaccharide deacetylase
IG195_18665	COG1131	(ABC) transporter
IG195_18705	COG1349	DNA-binding transcription factor activity
IG195_18710	COG0673	inositol 2-dehydrogenase activity
IG195_18720	COG3684	Belongs to the aldolase LacD family
IG195_18730	COG1175	transmembrane transport
IG195_18735	COG0395	ABC-type sugar transport system, permease component
IG195_18755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IG195_18765	COG2132	Multicopper oxidase
IG195_18770	COG2217	Heavy metal translocating P-type atpase
IG195_18805	COG3415	Transposase
IG195_18805	COG2801	Transposase and inactivated derivatives
IG195_18830	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IG195_18900	COG0067	glutamate synthase
IG195_18900	COG0069	glutamate synthase activity
IG195_18900	COG0070	glutamate synthase
IG195_18905	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IG195_18910	COG0159	tryptophan synthase activity
IG195_18915	COG0133	tryptophan synthase activity
IG195_18920	COG0134	indole-3-glycerol-phosphate synthase activity
IG195_18940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IG195_18950	COG0107	imidazoleglycerol-phosphate synthase activity
IG195_18955	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IG195_18960	COG0140	phosphoribosyl-ATP diphosphatase activity
IG195_18965	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IG195_18970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IG195_18975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IG195_18975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IG195_18995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IG195_19005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IG195_19010	COG0242	peptide deformylase activity
IG195_19065	COG0531	amino acid
IG195_19075	COG3135	benzoate transporter
IG195_19095	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IG195_19110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IG195_19135	COG0183	Belongs to the thiolase family
IG195_19140	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG195_19140	COG1024	Enoyl-CoA hydratase
IG195_19145	COG0667	Aldo Keto reductase
IG195_19165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IG195_19170	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IG195_19175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IG195_19180	COG0531	amino acid
IG195_19185	COG0569	domain protein
IG195_19210	COG0756	dUTP diphosphatase activity
IG195_19235	COG0640	Transcriptional regulator
IG195_19300	COG1937	Protein conserved in bacteria
IG195_19305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IG195_19320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IG195_19335	COG0586	Pfam SNARE associated Golgi protein
IG195_19340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG195_19345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG195_19360	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IG195_19395	COG2205	protein histidine kinase activity
IG195_19400	COG0745	RESPONSE REGULATOR receiver
IG195_19415	COG0586	Pfam SNARE associated Golgi protein
IG195_19455	COG1802	Transcriptional regulator
IG195_19530	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG195_19545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IG195_19600	COG3608	succinylglutamate desuccinylase aspartoacylase
IG195_19600	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IG195_19975	COG3547	Transposase (IS116 IS110 IS902 family)
IG195_20000	COG2186	Transcriptional regulator
IG195_20005	COG1620	l-lactate permease
IG195_20010	COG0247	lactate metabolic process
IG195_20015	COG1139	Iron-sulfur cluster binding protein
IG195_20020	COG1556	Lactate utilization protein
IG195_20030	COG1802	Transcriptional regulator
IG195_20035	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IG195_20040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IG195_20045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IG195_20080	COG0789	Transcriptional regulator
IG195_20130	COG1192	Involved in chromosome partitioning
IG195_20260	COG2323	membrane
IG195_20320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IG195_20330	COG2372	response to copper ion
IG195_20355	COG3336	cytochrome c oxidase
IG195_20360	COG0640	Transcriptional regulator
IG195_20380	COG0739	heme binding
IG195_20385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IG195_20405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IG195_20430	COG1321	iron dependent repressor
IG195_20435	COG3547	Transposase (IS116 IS110 IS902 family)
IG195_20450	COG0588	phosphoglycerate mutase activity
IG195_20460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IG195_20465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IG195_20470	COG2814	Major facilitator Superfamily
IG195_20475	COG5002	protein histidine kinase activity
IG195_20505	COG2814	Major facilitator Superfamily
IG195_20515	COG1388	LysM domain
IG195_20515	COG3103	Sh3 type 3 domain protein
IG195_20515	COG0791	NLP P60 protein
IG195_20555	COG0438	transferase activity, transferring glycosyl groups
IG195_20580	COG0785	Cytochrome C biogenesis protein
IG195_20585	COG2132	Multicopper oxidase
IG195_20630	COG2217	Heavy metal translocating P-type atpase
IG195_20655	COG2217	Heavy metal translocating P-type atpase
IG195_20660	COG0640	Transcriptional regulator
IG195_20665	COG2814	Major facilitator Superfamily
IG195_20670	COG0640	Transcriptional regulator
IG195_20730	COG1937	Protein conserved in bacteria
IG195_20735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IG195_20750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IG195_20755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG195_20765	COG0586	Pfam SNARE associated Golgi protein
IG195_20770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG195_20785	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IG195_20835	COG0586	Pfam SNARE associated Golgi protein
IG195_20935	COG0765	amino acid transport
IG195_20945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG195_20995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IG195_21000	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IG195_21005	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IG195_21030	COG1120	ATPase activity
IG195_21035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IG195_21040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IG195_21080	COG3012	SEC-C Motif Domain Protein
IG195_21095	COG0667	Aldo Keto reductase
IG195_21250	COG0531	amino acid
IG195_21265	COG0531	amino acid
IG195_21275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IG195_21290	COG3039	Transposase
IG195_21300	COG0549	Belongs to the carbamate kinase family
IG195_21335	COG2252	PERMEase
IG195_21360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IG195_21375	COG2132	Multicopper oxidase
IG195_21395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IG195_21415	COG1937	Protein conserved in bacteria
IG195_21430	COG0789	Transcriptional regulator
IG195_21440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IG195_21480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IG195_21500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IG195_21540	COG0210	DNA helicase
IG195_21555	COG4974	Belongs to the 'phage' integrase family
IG195_21580	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IG195_21675	COG3547	Transposase (IS116 IS110 IS902 family)
IG195_21690	COG0583	DNA-binding transcription factor activity
IG195_21695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IG195_21705	COG2801	Transposase and inactivated derivatives
IG195_21705	COG3415	Transposase
IG195_21710	COG0477	Major facilitator Superfamily
IG195_21715	COG0006	proline dipeptidase activity
IG195_21770	COG3328	transposase activity
IG195_21800	COG1192	Involved in chromosome partitioning
IG195_21995	COG1204	response to ionizing radiation
IG195_22005	COG1473	amidohydrolase
IG195_22010	COG1012	belongs to the aldehyde dehydrogenase family
IG195_22015	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IG195_22020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IG195_22035	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IG195_22045	COG1028	Short-chain dehydrogenase reductase Sdr
IG195_22050	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IG195_22055	COG2124	cytochrome p450
IG195_22075	COG0512	Glutamine amidotransferase of anthranilate synthase
IG195_22090	COG0686	Belongs to the AlaDH PNT family
IG195_22105	COG2220	Zn-dependent hydrolases of the beta-lactamase fold