locus-tag	class	description
E7Y32_00010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E7Y32_00020	COG0508	dehydrogenase complex catalyzes the overall conversion of
E7Y32_00025	COG0022	dehydrogenase e1 component
E7Y32_00040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E7Y32_00050	COG3275	phosphorelay sensor kinase activity
E7Y32_00065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E7Y32_00075	COG0575	Belongs to the CDS family
E7Y32_00080	COG0233	cytoplasmic translational termination
E7Y32_00085	COG0528	UMP kinase activity
E7Y32_00090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E7Y32_00095	COG0052	Belongs to the universal ribosomal protein uS2 family
E7Y32_00115	COG0297	glycogen (starch) synthase activity
E7Y32_00125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E7Y32_00135	COG2814	Major facilitator Superfamily
E7Y32_00170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E7Y32_00170	COG0574	Belongs to the PEP-utilizing enzyme family
E7Y32_00180	COG1414	Transcriptional regulator
E7Y32_00205	COG0358	DNA primase activity
E7Y32_00240	COG2031	fatty acid transporter
E7Y32_00250	COG0423	glycine-tRNA ligase activity
E7Y32_00265	COG0400	carboxylic ester hydrolase activity
E7Y32_00300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E7Y32_00305	COG2873	o-acetylhomoserine
E7Y32_00335	COG1228	amidohydrolase
E7Y32_00350	COG1063	alcohol dehydrogenase
E7Y32_00355	COG0583	DNA-binding transcription factor activity
E7Y32_00360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E7Y32_00365	COG0154	amidase activity
E7Y32_00370	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E7Y32_00375	COG2851	Citrate transporter
E7Y32_00385	COG4565	transcriptional regulatory protein
E7Y32_00395	COG0483	inositol monophosphate 1-phosphatase activity
E7Y32_00400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E7Y32_00405	COG0631	protein serine/threonine phosphatase activity
E7Y32_00420	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E7Y32_00420	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E7Y32_00425	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_00430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E7Y32_00465	COG2409	Drug exporters of the RND superfamily
E7Y32_00475	COG0424	maF-like protein
E7Y32_00480	COG4770	biotin carboxylase activity
E7Y32_00490	COG0477	Major facilitator Superfamily
E7Y32_00505	COG2223	nitrite transmembrane transporter activity
E7Y32_00510	COG0243	molybdopterin cofactor binding
E7Y32_00515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E7Y32_00545	COG0438	transferase activity, transferring glycosyl groups
E7Y32_00565	COG1959	2 iron, 2 sulfur cluster binding
E7Y32_00570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E7Y32_00580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E7Y32_00600	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E7Y32_00610	COG1988	membrane-bound metal-dependent
E7Y32_00620	COG0702	epimerase
E7Y32_00640	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E7Y32_00645	COG0822	iron-sulfur transferase activity
E7Y32_00695	COG4412	M6 family metalloprotease domain protein
E7Y32_00695	COG3291	Pkd domain containing protein
E7Y32_00740	COG0542	response to heat
E7Y32_00745	COG4566	intracellular signal transduction
E7Y32_00750	COG0193	aminoacyl-tRNA hydrolase activity
E7Y32_00755	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E7Y32_00765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E7Y32_00775	COG1309	transcriptional regulator
E7Y32_00780	COG0488	(ABC) transporter
E7Y32_00785	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E7Y32_00790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E7Y32_00795	COG3583	domain protein
E7Y32_00800	COG0084	hydrolase, TatD family'
E7Y32_00805	COG0714	Associated with various cellular activities
E7Y32_00865	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E7Y32_00915	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E7Y32_00925	COG1482	cell wall glycoprotein biosynthetic process
E7Y32_00940	COG1494	fructose-1,6-bisphosphatase
E7Y32_00950	COG0288	reversible hydration of carbon dioxide
E7Y32_00955	COG0114	fumarate hydratase activity
E7Y32_00985	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E7Y32_00990	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E7Y32_01000	COG1331	Highly conserved protein containing a thioredoxin domain
E7Y32_01010	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E7Y32_01020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E7Y32_01030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E7Y32_01040	COG2017	converts alpha-aldose to the beta-anomer
E7Y32_01050	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E7Y32_01055	COG0183	Belongs to the thiolase family
E7Y32_01105	COG1252	NADH dehydrogenase
E7Y32_01130	COG0148	phosphopyruvate hydratase activity
E7Y32_01135	COG3956	TIGRFAM MazG family protein
E7Y32_01140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E7Y32_01145	COG0586	Pfam SNARE associated Golgi protein
E7Y32_01180	COG1744	ABC transporter substrate-binding protein PnrA-like
E7Y32_01185	COG2130	NADP-dependent
E7Y32_01190	COG1764	response to oxidative stress
E7Y32_01195	COG1846	Transcriptional regulator
E7Y32_01200	COG1473	amidohydrolase
E7Y32_01200	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E7Y32_01210	COG2009	succinate dehydrogenase
E7Y32_01225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E7Y32_01245	COG0180	Tryptophanyl-tRNA synthetase
E7Y32_01270	COG1131	(ABC) transporter
E7Y32_01275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E7Y32_01300	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E7Y32_01320	COG4213	ABC transporter substrate-binding protein
E7Y32_01325	COG0673	inositol 2-dehydrogenase activity
E7Y32_01335	COG0515	serine threonine protein kinase
E7Y32_01335	COG2815	serine threonine protein kinase
E7Y32_01350	COG2838	Isocitrate dehydrogenase
E7Y32_01360	COG0138	bifunctional purine biosynthesis protein purh
E7Y32_01365	COG0477	Major facilitator Superfamily
E7Y32_01390	COG2268	Band 7 protein
E7Y32_01405	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E7Y32_01415	COG5001	Diguanylate cyclase
E7Y32_01420	COG5001	Diguanylate cyclase
E7Y32_01475	COG3665	Urea carboxylase-associated protein
E7Y32_01515	COG1278	Cold shock
E7Y32_01545	COG2072	flavoprotein involved in K transport
E7Y32_01560	COG1401	restriction endodeoxyribonuclease activity
E7Y32_01625	COG1074	ATP-dependent DNA helicase activity
E7Y32_01640	COG1609	Transcriptional regulator
E7Y32_01660	COG0366	Alpha amylase catalytic
E7Y32_01675	COG2304	oxidoreductase activity
E7Y32_01705	COG3853	Toxic anion resistance protein (TelA)
E7Y32_01730	COG1358	cellular component organization or biogenesis
E7Y32_01760	COG2813	Specifically methylates the guanine in position
E7Y32_01780	COG0477	Major facilitator Superfamily
E7Y32_01800	COG1254	Belongs to the acylphosphatase family
E7Y32_01850	COG0667	Aldo Keto reductase
E7Y32_01855	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E7Y32_01880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E7Y32_01910	COG2183	response to ionizing radiation
E7Y32_01925	COG1902	pentaerythritol trinitrate reductase activity
E7Y32_01960	COG1401	restriction endodeoxyribonuclease activity
E7Y32_01995	COG0028	Belongs to the TPP enzyme family
E7Y32_02010	COG1396	sequence-specific DNA binding
E7Y32_02045	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E7Y32_02055	COG1846	Transcriptional regulator
E7Y32_02070	COG0640	Transcriptional regulator
E7Y32_02085	COG0045	succinate-CoA ligase (ADP-forming) activity
E7Y32_02105	COG0483	inositol monophosphate 1-phosphatase activity
E7Y32_02145	COG1132	(ABC) transporter
E7Y32_02150	COG0488	(ABC) transporter
E7Y32_02175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E7Y32_02180	COG0303	'Molybdopterin
E7Y32_02200	COG0739	heme binding
E7Y32_02210	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E7Y32_02215	COG2814	Major facilitator Superfamily
E7Y32_02225	COG1278	Cold shock
E7Y32_02255	COG0745	RESPONSE REGULATOR receiver
E7Y32_02260	COG2205	protein histidine kinase activity
E7Y32_02275	COG0459	protein refolding
E7Y32_02285	COG1278	Cold shock
E7Y32_02300	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E7Y32_02320	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
E7Y32_02330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E7Y32_02335	COG0509	glycine decarboxylation via glycine cleavage system
E7Y32_02340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E7Y32_02345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E7Y32_02345	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E7Y32_02355	COG0328	RNA-DNA hybrid ribonuclease activity
E7Y32_02365	COG0477	Major facilitator Superfamily
E7Y32_02370	COG0783	Belongs to the Dps family
E7Y32_02385	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E7Y32_02395	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E7Y32_02400	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E7Y32_02410	COG1987	bacterial-type flagellum assembly
E7Y32_02415	COG1338	Plays a role in the flagellum-specific transport system
E7Y32_02425	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E7Y32_02435	COG1360	Flagellar Motor Protein
E7Y32_02450	COG2124	cytochrome p450
E7Y32_02460	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E7Y32_02470	COG0791	NLP P60 protein
E7Y32_02480	COG1157	protein secretion by the type III secretion system
E7Y32_02490	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E7Y32_02495	COG1766	The M ring may be actively involved in energy transduction
E7Y32_02500	COG1677	Flagellar hook-basal body complex protein FliE
E7Y32_02505	COG1558	bacterial-type flagellum-dependent cell motility
E7Y32_02510	COG1815	bacterial-type flagellum-dependent cell motility
E7Y32_02525	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E7Y32_02530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E7Y32_02540	COG4786	Flagellar basal body rod
E7Y32_02540	COG1256	bacterial-type flagellum assembly
E7Y32_02545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E7Y32_02550	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E7Y32_02570	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_02600	COG3842	ATPase activity
E7Y32_02610	COG0277	FAD linked oxidase domain protein
E7Y32_02615	COG0366	Alpha amylase catalytic
E7Y32_02620	COG3833	ABC-type maltose transport systems, permease component
E7Y32_02635	COG0366	Alpha amylase catalytic
E7Y32_02640	COG1609	Transcriptional regulator
E7Y32_02665	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E7Y32_02675	COG0366	Alpha amylase catalytic
E7Y32_02710	COG0215	cysteine-tRNA ligase activity
E7Y32_02720	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E7Y32_02725	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E7Y32_02745	COG5002	protein histidine kinase activity
E7Y32_02755	COG0588	phosphoglycerate mutase activity
E7Y32_02775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E7Y32_02780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E7Y32_02820	COG0656	L-ascorbic acid biosynthetic process
E7Y32_02840	COG1966	Carbon starvation protein
E7Y32_02850	COG0604	alcohol dehydrogenase
E7Y32_02870	COG0346	lactoylglutathione lyase activity
E7Y32_02880	COG0737	Belongs to the 5'-nucleotidase family
E7Y32_02885	COG1215	transferase activity, transferring glycosyl groups
E7Y32_02900	COG1505	serine-type exopeptidase activity
E7Y32_02915	COG0514	ATP-dependent DNA helicase (RecQ)
E7Y32_02935	COG1017	nitric oxide dioxygenase activity
E7Y32_02935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E7Y32_02940	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E7Y32_02965	COG1511	domain protein
E7Y32_02970	COG1309	transcriptional regulator
E7Y32_02990	COG2062	phosphohistidine phosphatase, SixA
E7Y32_03005	COG0745	RESPONSE REGULATOR receiver
E7Y32_03010	COG2205	protein histidine kinase activity
E7Y32_03025	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E7Y32_03030	COG0671	phosphoesterase, PA-phosphatase related
E7Y32_03035	COG0590	tRNA wobble adenosine to inosine editing
E7Y32_03045	COG0438	transferase activity, transferring glycosyl groups
E7Y32_03100	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E7Y32_03125	COG1201	RNA secondary structure unwinding
E7Y32_03130	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E7Y32_03135	COG2364	Membrane
E7Y32_03150	COG0564	pseudouridine synthase activity
E7Y32_03165	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E7Y32_03175	COG0667	Aldo Keto reductase
E7Y32_03180	COG1309	transcriptional regulator
E7Y32_03195	COG1960	acyl-CoA dehydrogenase activity
E7Y32_03220	COG3842	ATPase activity
E7Y32_03260	COG0343	queuine tRNA-ribosyltransferase activity
E7Y32_03280	COG0477	Major facilitator Superfamily
E7Y32_03285	COG0351	phosphomethylpyrimidine kinase
E7Y32_03295	COG0028	Belongs to the TPP enzyme family
E7Y32_03300	COG1396	sequence-specific DNA binding
E7Y32_03360	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E7Y32_03365	COG1063	alcohol dehydrogenase
E7Y32_03410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E7Y32_03435	COG1846	Transcriptional regulator
E7Y32_03470	COG0047	phosphoribosylformylglycinamidine synthase activity
E7Y32_03475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E7Y32_03500	COG4762	Protein conserved in bacteria
E7Y32_03505	COG2315	Protein conserved in bacteria
E7Y32_03515	COG1832	CoA-binding protein
E7Y32_03520	COG1116	anion transmembrane transporter activity
E7Y32_03530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E7Y32_03535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E7Y32_03550	COG1832	CoA-binding protein
E7Y32_03570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E7Y32_03590	COG0191	fructose-bisphosphate aldolase activity
E7Y32_03600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E7Y32_03600	COG0357	Ribosomal RNA small subunit methyltransferase G
E7Y32_03625	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E7Y32_03630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E7Y32_03635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E7Y32_03640	COG0508	dehydrogenase complex catalyzes the overall conversion of
E7Y32_03640	COG0022	dehydrogenase e1 component
E7Y32_03645	COG0508	dehydrogenase complex catalyzes the overall conversion of
E7Y32_03660	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E7Y32_03675	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E7Y32_03685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E7Y32_03700	COG3848	Pyruvate phosphate dikinase
E7Y32_03700	COG0574	Belongs to the PEP-utilizing enzyme family
E7Y32_03720	COG1278	Cold shock
E7Y32_03725	COG1280	lysine exporter protein (LysE YggA)
E7Y32_03745	COG0477	Major facilitator Superfamily
E7Y32_03760	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_03780	COG0583	DNA-binding transcription factor activity
E7Y32_03785	COG1960	acyl-CoA dehydrogenase activity
E7Y32_03790	COG2318	DinB family
E7Y32_03795	COG3706	GGDEF domain
E7Y32_03795	COG0745	RESPONSE REGULATOR receiver
E7Y32_03800	COG1960	acyl-CoA dehydrogenase activity
E7Y32_03805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E7Y32_03840	COG1024	Enoyl-CoA hydratase
E7Y32_03860	COG1609	Transcriptional regulator
E7Y32_03915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E7Y32_03920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E7Y32_03940	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E7Y32_03940	COG1796	DNA polymerase
E7Y32_03950	COG0583	DNA-binding transcription factor activity
E7Y32_03955	COG0697	spore germination
E7Y32_03990	COG0574	Belongs to the PEP-utilizing enzyme family
E7Y32_03990	COG3848	Pyruvate phosphate dikinase
E7Y32_04010	COG2252	PERMEase
E7Y32_04015	COG0010	Belongs to the arginase family
E7Y32_04020	COG3263	regulation of cellular component size
E7Y32_04040	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E7Y32_04065	COG1280	lysine exporter protein (LysE YggA)
E7Y32_04070	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_04105	COG1295	ribonuclease BN
E7Y32_04135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E7Y32_04135	COG0574	Belongs to the PEP-utilizing enzyme family
E7Y32_04210	COG1131	(ABC) transporter
E7Y32_04215	COG3559	Exporter of polyketide antibiotics
E7Y32_04230	COG2733	membrane
E7Y32_04250	COG1140	nitrate reductase beta subunit
E7Y32_04265	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E7Y32_04280	COG1012	belongs to the aldehyde dehydrogenase family
E7Y32_04295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E7Y32_04315	COG1349	DNA-binding transcription factor activity
E7Y32_04320	COG1105	Belongs to the carbohydrate kinase PfkB family
E7Y32_04325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E7Y32_04325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E7Y32_04325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E7Y32_04345	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E7Y32_04370	COG0477	Major facilitator Superfamily
E7Y32_04380	COG0300	oxidoreductase activity
E7Y32_04405	COG2610	gluconate transmembrane transporter activity
E7Y32_04410	COG2084	Dehydrogenase
E7Y32_04425	COG1937	Protein conserved in bacteria
E7Y32_04435	COG3360	Dodecin
E7Y32_04440	COG0667	Aldo Keto reductase
E7Y32_04445	COG2261	transglycosylase associated protein
E7Y32_04455	COG2890	protein-(glutamine-N5) methyltransferase activity
E7Y32_04490	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E7Y32_04510	COG4974	Belongs to the 'phage' integrase family
E7Y32_04535	COG0306	phosphate transporter
E7Y32_04540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E7Y32_04585	COG2217	Heavy metal translocating P-type atpase
E7Y32_04590	COG2226	methyltransferase
E7Y32_04610	COG2815	serine threonine protein kinase
E7Y32_04610	COG0515	serine threonine protein kinase
E7Y32_04615	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E7Y32_04620	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
E7Y32_04635	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E7Y32_04635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E7Y32_04635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E7Y32_04640	COG1461	Dihydroxyacetone kinase
E7Y32_04645	COG2376	Dihydroxyacetone kinase
E7Y32_04650	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E7Y32_04655	COG1506	peptidase
E7Y32_04655	COG0823	Involved in the tonB-independent uptake of proteins
E7Y32_04665	COG0542	response to heat
E7Y32_04680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E7Y32_04690	COG1435	thymidine kinase activity
E7Y32_04700	COG2814	Major facilitator Superfamily
E7Y32_04705	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E7Y32_04740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E7Y32_04745	COG0302	gtp cyclohydrolase
E7Y32_04750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E7Y32_04760	COG0037	tRNA processing
E7Y32_04780	COG2272	Belongs to the type-B carboxylesterase lipase family
E7Y32_04795	COG0561	phosphatase activity
E7Y32_04800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E7Y32_04805	COG1597	lipid kinase activity
E7Y32_04820	COG0425	Belongs to the sulfur carrier protein TusA family
E7Y32_04820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E7Y32_04825	COG0154	amidase activity
E7Y32_04835	COG3104	oligopeptide transport
E7Y32_04850	COG0800	Aldolase
E7Y32_04855	COG2721	sulfolactate sulfo-lyase activity
E7Y32_04860	COG4948	Mandelate Racemase Muconate Lactonizing
E7Y32_04865	COG1904	glucuronate isomerase
E7Y32_04870	COG1609	Transcriptional regulator
E7Y32_04880	COG3842	ATPase activity
E7Y32_04890	COG0395	ABC-type sugar transport system, permease component
E7Y32_04895	COG0246	Mannitol dehydrogenase
E7Y32_04910	COG3706	GGDEF domain
E7Y32_04920	COG0778	Nitroreductase
E7Y32_04935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E7Y32_04960	COG4585	Histidine kinase
E7Y32_04965	COG2197	response regulator
E7Y32_04970	COG2233	PERMEase
E7Y32_04980	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_04995	COG0477	Major facilitator Superfamily
E7Y32_05000	COG1929	Belongs to the glycerate kinase type-1 family
E7Y32_05005	COG0328	RNA-DNA hybrid ribonuclease activity
E7Y32_05005	COG0406	alpha-ribazole phosphatase activity
E7Y32_05010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E7Y32_05015	COG0584	glycerophosphoryl diester phosphodiesterase
E7Y32_05025	COG0561	phosphatase activity
E7Y32_05045	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E7Y32_05070	COG0385	Bile acid
E7Y32_05090	COG4770	biotin carboxylase activity
E7Y32_05095	COG1984	allophanate hydrolase subunit 2
E7Y32_05100	COG0477	Major facilitator Superfamily
E7Y32_05105	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E7Y32_05130	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E7Y32_05145	COG1715	Restriction endonuclease
E7Y32_05215	COG1716	ATPase activity
E7Y32_05220	COG1716	ATPase activity
E7Y32_05235	COG0768	penicillin binding
E7Y32_05240	COG0515	serine threonine protein kinase
E7Y32_05260	COG2818	Glycosylase
E7Y32_05265	COG0705	Rhomboid family
E7Y32_05280	COG1215	transferase activity, transferring glycosyl groups
E7Y32_05300	COG3266	domain, Protein
E7Y32_05305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E7Y32_05310	COG0187	DNA topoisomerase II activity
E7Y32_05315	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
E7Y32_05320	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E7Y32_05325	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
E7Y32_05330	COG0592	DNA-directed DNA polymerase activity
E7Y32_05335	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E7Y32_05340	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E7Y32_05345	COG0594	ribonuclease P activity
E7Y32_05350	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E7Y32_05355	COG0706	membrane insertase activity
E7Y32_05365	COG0357	Ribosomal RNA small subunit methyltransferase G
E7Y32_05370	COG1192	Involved in chromosome partitioning
E7Y32_05380	COG3118	belongs to the thioredoxin family
E7Y32_05385	COG0492	ferredoxin-NADP+ reductase activity
E7Y32_05410	COG0617	tRNA 3'-terminal CCA addition
E7Y32_05415	COG0406	alpha-ribazole phosphatase activity
E7Y32_05430	COG0577	efflux transmembrane transporter activity
E7Y32_05430	COG1136	(ABC) transporter
E7Y32_05445	COG2197	response regulator
E7Y32_05450	COG0768	penicillin binding
E7Y32_05455	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E7Y32_05475	COG0477	Major facilitator Superfamily
E7Y32_05480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E7Y32_05485	COG0154	amidase activity
E7Y32_05490	COG0488	(ABC) transporter
E7Y32_05495	COG0738	Major facilitator superfamily
E7Y32_05510	COG1131	(ABC) transporter
E7Y32_05530	COG1362	aminopeptidase activity
E7Y32_05540	COG0360	Binds together with S18 to 16S ribosomal RNA
E7Y32_05550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E7Y32_05555	COG0359	binds to the 23S rRNA
E7Y32_05590	COG0305	Participates in initiation and elongation during chromosome replication
E7Y32_05595	COG1607	acyl-coa hydrolase
E7Y32_05645	COG1937	Protein conserved in bacteria
E7Y32_05670	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E7Y32_05680	COG1793	dna ligase
E7Y32_05685	COG0477	Major facilitator Superfamily
E7Y32_05690	COG1414	Transcriptional regulator
E7Y32_05695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E7Y32_05700	COG3185	4-Hydroxyphenylpyruvate dioxygenase
E7Y32_05705	COG3485	protocatechuate 3,4-dioxygenase
E7Y32_05710	COG3485	protocatechuate 3,4-dioxygenase
E7Y32_05715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E7Y32_05725	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E7Y32_05730	COG0183	Belongs to the thiolase family
E7Y32_05740	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E7Y32_05745	COG1414	Transcriptional regulator
E7Y32_05755	COG1597	lipid kinase activity
E7Y32_05765	COG1970	mechanosensitive ion channel activity
E7Y32_05775	COG1414	Transcriptional regulator
E7Y32_05790	COG1178	ABC-type Fe3 transport system permease component
E7Y32_05795	COG3842	ATPase activity
E7Y32_05800	COG1840	ABC-type Fe3 transport system, periplasmic component
E7Y32_05825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E7Y32_05840	COG1950	PFAM Membrane protein of
E7Y32_05845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E7Y32_05855	COG0022	dehydrogenase e1 component
E7Y32_05860	COG0508	dehydrogenase complex catalyzes the overall conversion of
E7Y32_05865	COG0583	DNA-binding transcription factor activity
E7Y32_05880	COG3485	protocatechuate 3,4-dioxygenase
E7Y32_05885	COG2271	Major facilitator Superfamily
E7Y32_05890	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_05895	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E7Y32_05905	COG0318	PFAM AMP-dependent synthetase and ligase
E7Y32_05915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E7Y32_05950	COG0673	inositol 2-dehydrogenase activity
E7Y32_05955	COG0686	Belongs to the AlaDH PNT family
E7Y32_05975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E7Y32_05985	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E7Y32_05985	COG2213	PTS system mannitol-specific
E7Y32_05990	COG0246	Mannitol dehydrogenase
E7Y32_05995	COG1113	amino acid transport
E7Y32_06005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E7Y32_06010	COG2814	Major facilitator Superfamily
E7Y32_06015	COG0477	Major facilitator Superfamily
E7Y32_06020	COG0477	Major facilitator Superfamily
E7Y32_06025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E7Y32_06035	COG1309	transcriptional regulator
E7Y32_06050	COG1280	lysine exporter protein (LysE YggA)
E7Y32_06055	COG1522	sequence-specific DNA binding
E7Y32_06065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E7Y32_06075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E7Y32_06090	COG0039	L-malate dehydrogenase activity
E7Y32_06145	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_06155	COG3958	Transketolase
E7Y32_06160	COG3959	Transketolase, thiamine diphosphate binding domain
E7Y32_06170	COG1082	Xylose isomerase domain protein TIM barrel
E7Y32_06175	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_06180	COG2376	Dihydroxyacetone kinase
E7Y32_06185	COG0698	ribose 5-phosphate isomerase
E7Y32_06200	COG0667	Aldo Keto reductase
E7Y32_06210	COG3012	SEC-C Motif Domain Protein
E7Y32_06285	COG1017	nitric oxide dioxygenase activity
E7Y32_06285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E7Y32_06290	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E7Y32_06295	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E7Y32_06300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E7Y32_06340	COG0776	regulation of translation
E7Y32_06345	COG3336	cytochrome c oxidase
E7Y32_06365	COG0433	COG0433 Predicted ATPase
E7Y32_06375	COG0667	Aldo Keto reductase
E7Y32_06380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E7Y32_06400	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E7Y32_06410	COG0531	amino acid
E7Y32_06415	COG1012	belongs to the aldehyde dehydrogenase family
E7Y32_06425	COG0583	DNA-binding transcription factor activity
E7Y32_06445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E7Y32_06450	COG0717	Belongs to the dCTP deaminase family
E7Y32_06455	COG0475	glutathione-regulated potassium exporter activity
E7Y32_06470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E7Y32_06470	COG2111	Na H antiporter
E7Y32_06485	COG1863	multisubunit Na H antiporter MnhE subunit
E7Y32_06490	COG2212	antiporter activity
E7Y32_06495	COG1320	monovalent cation:proton antiporter activity
E7Y32_06505	COG4702	Belongs to the UPF0303 family
E7Y32_06510	COG4721	ABC-type cobalt transport system, permease component
E7Y32_06515	COG1122	ATPase activity
E7Y32_06525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E7Y32_06530	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E7Y32_06555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E7Y32_06560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E7Y32_06560	COG0512	Glutamine amidotransferase of anthranilate synthase
E7Y32_06565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E7Y32_06570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E7Y32_06580	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_06590	COG1960	acyl-CoA dehydrogenase activity
E7Y32_06640	COG2409	Drug exporters of the RND superfamily
E7Y32_06660	COG0443	Heat shock 70 kDa protein
E7Y32_06665	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E7Y32_06670	COG0484	heat shock protein binding
E7Y32_06675	COG0789	Transcriptional regulator
E7Y32_06685	COG3971	2-oxopent-4-enoate hydratase activity
E7Y32_06695	COG1012	belongs to the aldehyde dehydrogenase family
E7Y32_06700	COG1802	Transcriptional regulator
E7Y32_06715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E7Y32_06745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E7Y32_06755	COG0477	Major facilitator Superfamily
E7Y32_06785	COG0667	Aldo Keto reductase
E7Y32_06790	COG2076	Multidrug Resistance protein
E7Y32_06795	COG2076	Multidrug Resistance protein
E7Y32_06810	COG3842	ATPase activity
E7Y32_06815	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E7Y32_06820	COG1176	ABC-type spermidine putrescine transport system, permease component I
E7Y32_06825	COG1177	transmembrane transport
E7Y32_06835	COG0135	phosphoribosylanthranilate isomerase activity
E7Y32_06885	COG2353	YceI-like domain
E7Y32_06920	COG3585	molybdate ion transport
E7Y32_06945	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E7Y32_06950	COG1929	Belongs to the glycerate kinase type-1 family
E7Y32_06955	COG3246	L-lysine catabolic process to acetate
E7Y32_06975	COG0542	response to heat
E7Y32_07005	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E7Y32_07020	COG0357	Ribosomal RNA small subunit methyltransferase G
E7Y32_07035	COG3622	Belongs to the hyi family
E7Y32_07045	COG2267	carboxylic ester hydrolase activity
E7Y32_07065	COG1132	(ABC) transporter
E7Y32_07075	COG0438	transferase activity, transferring glycosyl groups
E7Y32_07085	COG5002	protein histidine kinase activity
E7Y32_07090	COG0745	RESPONSE REGULATOR receiver
E7Y32_07100	COG2132	Multicopper oxidase
E7Y32_07145	COG1053	succinate dehydrogenase
E7Y32_07155	COG1802	Transcriptional regulator
E7Y32_07165	COG3842	ATPase activity
E7Y32_07175	COG1840	ABC-type Fe3 transport system, periplasmic component
E7Y32_07190	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E7Y32_07195	COG4867	von Willebrand factor, type A
E7Y32_07215	COG4941	Belongs to the sigma-70 factor family
E7Y32_07225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E7Y32_07240	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E7Y32_07255	COG1760	l-serine dehydratase
E7Y32_07280	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E7Y32_07320	COG0515	serine threonine protein kinase
E7Y32_07320	COG2815	serine threonine protein kinase
E7Y32_07330	COG1846	Transcriptional regulator
E7Y32_07340	COG2271	Major facilitator Superfamily
E7Y32_07350	COG4948	Mandelate Racemase Muconate Lactonizing
E7Y32_07365	COG0179	Fumarylacetoacetate (FAA) hydrolase
E7Y32_07370	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_07390	COG0765	amino acid transport
E7Y32_07395	COG1126	abc transporter atp-binding protein
E7Y32_07400	COG1063	alcohol dehydrogenase
E7Y32_07405	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_07410	COG0800	Aldolase
E7Y32_07415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E7Y32_07420	COG1984	allophanate hydrolase subunit 2
E7Y32_07425	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E7Y32_07430	COG0439	Biotin carboxylase
E7Y32_07445	COG3835	regulator
E7Y32_07455	COG0252	asparaginase activity
E7Y32_07470	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_07475	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_07560	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_07565	COG0318	PFAM AMP-dependent synthetase and ligase
E7Y32_07610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E7Y32_07640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E7Y32_07650	COG2186	Transcriptional regulator
E7Y32_07665	COG0693	protein deglycase activity
E7Y32_07695	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E7Y32_07720	COG0589	response to stress
E7Y32_07725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E7Y32_07740	COG1175	transmembrane transport
E7Y32_07745	COG0395	ABC-type sugar transport system, permease component
E7Y32_07750	COG4948	Mandelate Racemase Muconate Lactonizing
E7Y32_07755	COG0800	Aldolase
E7Y32_07765	COG4948	Mandelate Racemase Muconate Lactonizing
E7Y32_07815	COG3387	PFAM Glycoside hydrolase 15-related
E7Y32_07825	COG0546	phosphoglycolate phosphatase activity
E7Y32_07835	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_07855	COG0151	Belongs to the GarS family
E7Y32_07860	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E7Y32_07885	COG1132	(ABC) transporter
E7Y32_07890	COG1132	(ABC) transporter
E7Y32_07895	COG1408	metallophosphoesterase
E7Y32_07900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E7Y32_07935	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E7Y32_07945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E7Y32_07970	COG0494	nUDIX hydrolase
E7Y32_08045	COG0789	Transcriptional regulator
E7Y32_08050	COG2890	protein-(glutamine-N5) methyltransferase activity
E7Y32_08065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E7Y32_08065	COG1754	DNA topoisomerase type I activity
E7Y32_08080	COG0248	Ppx GppA phosphatase
E7Y32_08100	COG0723	plastoquinol--plastocyanin reductase activity
E7Y32_08100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E7Y32_08105	COG0569	domain protein
E7Y32_08110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E7Y32_08115	COG0123	including yeast histone deacetylase and acetoin utilization protein
E7Y32_08120	COG0640	Transcriptional regulator
E7Y32_08125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E7Y32_08135	COG2186	Transcriptional regulator
E7Y32_08140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E7Y32_08155	COG0560	Phosphoserine phosphatase
E7Y32_08165	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E7Y32_08180	COG2353	YceI-like domain
E7Y32_08185	COG0406	alpha-ribazole phosphatase activity
E7Y32_08190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E7Y32_08195	COG0785	Cytochrome C biogenesis protein
E7Y32_08205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E7Y32_08235	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E7Y32_08245	COG1266	CAAX protease self-immunity
E7Y32_08255	COG0412	Dienelactone hydrolase
E7Y32_08260	COG3237	CsbD-like
E7Y32_08270	COG0183	Belongs to the thiolase family
E7Y32_08275	COG1024	Enoyl-CoA hydratase
E7Y32_08280	COG1250	3-hydroxyacyl-CoA dehydrogenase
E7Y32_08325	COG2723	6-phospho-beta-galactosidase activity
E7Y32_08335	COG2050	protein possibly involved in aromatic compounds catabolism
E7Y32_08340	COG2030	dehydratase
E7Y32_08340	COG1012	belongs to the aldehyde dehydrogenase family
E7Y32_08365	COG2050	protein possibly involved in aromatic compounds catabolism
E7Y32_08370	COG0280	phosphate acetyltransferase
E7Y32_08370	COG0857	belongs to the CobB CobQ family
E7Y32_08375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E7Y32_08400	COG1316	TRANSCRIPTIONal
E7Y32_08405	COG1316	TRANSCRIPTIONal
E7Y32_08410	COG3396	Phenylacetate-CoA oxygenase
E7Y32_08415	COG3460	Phenylacetate-CoA oxygenase
E7Y32_08420	COG3396	Phenylacetate-CoA oxygenase
E7Y32_08425	COG2151	metal-sulfur cluster biosynthetic enzyme
E7Y32_08430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E7Y32_08435	COG1024	Enoyl-CoA hydratase
E7Y32_08440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E7Y32_08445	COG4763	Acyl-transferase
E7Y32_08460	COG0022	dehydrogenase e1 component
E7Y32_08465	COG0508	dehydrogenase complex catalyzes the overall conversion of
E7Y32_08485	COG0297	glycogen (starch) synthase activity
E7Y32_08485	COG0438	transferase activity, transferring glycosyl groups
E7Y32_08500	COG0489	protein tyrosine kinase activity
E7Y32_08545	COG1621	beta-fructofuranosidase activity
E7Y32_08550	COG4948	Mandelate Racemase Muconate Lactonizing
E7Y32_08565	COG1846	Transcriptional regulator
E7Y32_08575	COG0018	arginyl-trna synthetase
E7Y32_08580	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E7Y32_08585	COG1126	abc transporter atp-binding protein
E7Y32_08590	COG0765	amino acid transport
E7Y32_08595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E7Y32_08600	COG1169	isochorismate synthase
E7Y32_08605	COG2226	methyltransferase
E7Y32_08610	COG0644	oxidoreductase
E7Y32_08630	COG2860	membrane
E7Y32_08640	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E7Y32_08660	COG1690	Belongs to the RtcB family
E7Y32_08670	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E7Y32_08685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E7Y32_08685	COG1648	precorrin-2 dehydrogenase activity
E7Y32_08710	COG3835	regulator
E7Y32_08715	COG1012	belongs to the aldehyde dehydrogenase family
E7Y32_08755	COG0531	amino acid
E7Y32_08780	COG0501	Belongs to the peptidase M48B family
E7Y32_08785	COG1666	GTP binding
E7Y32_08800	COG0596	Alpha beta hydrolase
E7Y32_08830	COG0346	lactoylglutathione lyase activity
E7Y32_08845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E7Y32_08855	COG0318	PFAM AMP-dependent synthetase and ligase
E7Y32_08870	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E7Y32_08885	COG1051	belongs to the nudix hydrolase family
E7Y32_08890	COG1733	regulation of RNA biosynthetic process
E7Y32_08905	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_08935	COG0702	epimerase
E7Y32_08940	COG1940	carbohydrate kinase activity
E7Y32_08945	COG0366	Alpha amylase catalytic
E7Y32_08950	COG4989	oxidoreductase activity
E7Y32_08970	COG0659	secondary active sulfate transmembrane transporter activity
E7Y32_08980	COG2030	dehydratase
E7Y32_08990	COG0738	Major facilitator superfamily
E7Y32_08995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E7Y32_09010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E7Y32_09025	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E7Y32_09035	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E7Y32_09040	COG0456	acetyltransferase
E7Y32_09050	COG0745	RESPONSE REGULATOR receiver
E7Y32_09060	COG3485	protocatechuate 3,4-dioxygenase
E7Y32_09070	COG0354	folic acid binding
E7Y32_09115	COG2197	response regulator
E7Y32_09120	COG0436	Aminotransferase
E7Y32_09140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E7Y32_09145	COG0081	regulation of translation
E7Y32_09160	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E7Y32_09165	COG0222	ribosome binding
E7Y32_09170	COG0737	Belongs to the 5'-nucleotidase family
E7Y32_09175	COG0442	prolyl-tRNA aminoacylation
E7Y32_09180	COG0183	Belongs to the thiolase family
E7Y32_09185	COG0085	RNA polymerase activity
E7Y32_09190	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E7Y32_09195	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E7Y32_09200	COG0049	tRNA binding
E7Y32_09205	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E7Y32_09210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E7Y32_09225	COG0051	transcription antitermination factor activity, RNA binding
E7Y32_09230	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E7Y32_09235	COG0088	Forms part of the polypeptide exit tunnel
E7Y32_09240	COG0089	rRNA binding
E7Y32_09245	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E7Y32_09250	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E7Y32_09255	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E7Y32_09260	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E7Y32_09265	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E7Y32_09270	COG0255	Belongs to the universal ribosomal protein uL29 family
E7Y32_09275	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E7Y32_09280	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E7Y32_09285	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E7Y32_09290	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E7Y32_09295	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E7Y32_09300	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E7Y32_09310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E7Y32_09315	COG1841	ribosomal large subunit assembly
E7Y32_09320	COG0200	Binds to the 23S rRNA
E7Y32_09330	COG0563	adenylate kinase activity
E7Y32_09350	COG1175	transmembrane transport
E7Y32_09355	COG3191	aminopeptidase activity
E7Y32_09360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E7Y32_09365	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E7Y32_09370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E7Y32_09375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E7Y32_09380	COG0202	RNA polymerase activity
E7Y32_09385	COG0203	ribosomal protein L17
E7Y32_09390	COG0101	tRNA pseudouridine synthase activity
E7Y32_09395	COG5002	protein histidine kinase activity
E7Y32_09425	COG1192	Involved in chromosome partitioning
E7Y32_09475	COG1192	Involved in chromosome partitioning
E7Y32_09495	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E7Y32_09500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E7Y32_09505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E7Y32_09510	COG1970	mechanosensitive ion channel activity
E7Y32_09515	COG1876	peptidase activity
E7Y32_09520	COG1072	(Pantothenic acid kinase))
E7Y32_09530	COG0736	holo-[acyl-carrier-protein] synthase activity
E7Y32_09555	COG0667	Aldo Keto reductase
E7Y32_09570	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E7Y32_09575	COG0438	transferase activity, transferring glycosyl groups
E7Y32_09585	COG1486	melibiose metabolic process
E7Y32_09595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E7Y32_09600	COG0802	atpase or kinase
E7Y32_09615	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E7Y32_09620	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E7Y32_09625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E7Y32_09640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E7Y32_09645	COG0459	protein refolding
E7Y32_09655	COG2755	lipolytic protein G-D-S-L family
E7Y32_09655	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E7Y32_09665	COG1132	(ABC) transporter
E7Y32_09675	COG1404	Belongs to the peptidase S8 family
E7Y32_09680	COG0516	GMP reductase activity
E7Y32_09685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E7Y32_09705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E7Y32_09705	COG0519	Catalyzes the synthesis of GMP from XMP
E7Y32_09725	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E7Y32_09730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E7Y32_09770	COG0589	response to stress
E7Y32_09795	COG4591	ABC-type transport system involved in lipoprotein release permease component
E7Y32_09800	COG0577	efflux transmembrane transporter activity
E7Y32_09800	COG1136	(ABC) transporter
E7Y32_09805	COG1611	Belongs to the LOG family
E7Y32_09820	COG2217	Heavy metal translocating P-type atpase
E7Y32_09830	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_09840	COG0488	(ABC) transporter
E7Y32_09850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E7Y32_09855	COG0598	Magnesium transport protein CorA
E7Y32_09875	COG0626	cystathionine gamma-synthase activity
E7Y32_09880	COG2814	Major facilitator Superfamily
E7Y32_09885	COG0583	DNA-binding transcription factor activity
E7Y32_09895	COG2971	BadF BadG BcrA BcrD
E7Y32_09910	COG1162	GTPase activity
E7Y32_09920	COG1174	glycine betaine transport
E7Y32_09925	COG1174	glycine betaine transport
E7Y32_09940	COG2326	polyphosphate kinase activity
E7Y32_09945	COG1722	exodeoxyribonuclease VII activity
E7Y32_09950	COG1570	exodeoxyribonuclease VII activity
E7Y32_09960	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E7Y32_09965	COG1322	Protein conserved in bacteria
E7Y32_09970	COG0012	GTP binding
E7Y32_09995	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E7Y32_10000	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_10020	COG1309	transcriptional regulator
E7Y32_10025	COG1136	(ABC) transporter
E7Y32_10035	COG4166	transmembrane transport
E7Y32_10055	COG4172	Belongs to the ABC transporter superfamily
E7Y32_10060	COG4166	transmembrane transport
E7Y32_10120	COG3226	Transcriptional regulator
E7Y32_10135	COG2171	N-acyltransferase activity
E7Y32_10140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E7Y32_10150	COG0765	amino acid transport
E7Y32_10155	COG0765	amino acid transport
E7Y32_10160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E7Y32_10165	COG1126	abc transporter atp-binding protein
E7Y32_10195	COG1595	DNA-templated transcription, initiation
E7Y32_10205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E7Y32_10220	COG2239	Acts as a magnesium transporter
E7Y32_10230	COG0006	proline dipeptidase activity
E7Y32_10240	COG2095	MarC family integral membrane protein
E7Y32_10245	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E7Y32_10250	COG0513	Belongs to the DEAD box helicase family
E7Y32_10265	COG0352	thiamine-phosphate diphosphorylase activity
E7Y32_10270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E7Y32_10280	COG2022	thiamine diphosphate biosynthetic process
E7Y32_10285	COG3795	YCII-related domain
E7Y32_10320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E7Y32_10325	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E7Y32_10350	COG0181	hydroxymethylbilane synthase activity
E7Y32_10360	COG0113	porphobilinogen synthase activity
E7Y32_10365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E7Y32_10370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E7Y32_10380	COG2011	ABC-type metal ion transport system permease component
E7Y32_10385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E7Y32_10425	COG2816	NAD+ diphosphatase activity
E7Y32_10445	COG0750	zinc metalloprotease
E7Y32_10450	COG1615	UPF0182 protein
E7Y32_10475	COG0415	Belongs to the DNA photolyase family
E7Y32_10480	COG1842	Phage shock protein A
E7Y32_10490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E7Y32_10495	COG2086	electron transfer activity
E7Y32_10500	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E7Y32_10510	COG3265	gluconokinase activity
E7Y32_10525	COG1595	DNA-templated transcription, initiation
E7Y32_10530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E7Y32_10540	COG1597	lipid kinase activity
E7Y32_10560	COG0697	spore germination
E7Y32_10575	COG0482	sulfurtransferase activity
E7Y32_10585	COG0601	transmembrane transport
E7Y32_10590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E7Y32_10595	COG4172	Belongs to the ABC transporter superfamily
E7Y32_10620	COG0714	Associated with various cellular activities
E7Y32_10645	COG5002	protein histidine kinase activity
E7Y32_10650	COG5401	PFAM Sporulation and spore germination
E7Y32_10655	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E7Y32_10660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E7Y32_10665	COG3214	Protein conserved in bacteria
E7Y32_10670	COG0653	protein targeting
E7Y32_10705	COG2902	Dehydrogenase
E7Y32_10725	COG1674	ftsk spoiiie
E7Y32_10780	COG0438	transferase activity, transferring glycosyl groups
E7Y32_10810	COG1216	Glycosyl transferase, family 2
E7Y32_10825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E7Y32_10865	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E7Y32_10870	COG2884	Cell division ATP-binding protein ftsE
E7Y32_10880	COG0739	heme binding
E7Y32_10885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E7Y32_10905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E7Y32_10910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E7Y32_10930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E7Y32_10935	COG0483	inositol monophosphate 1-phosphatase activity
E7Y32_10945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E7Y32_10955	COG1595	DNA-templated transcription, initiation
E7Y32_10980	COG0508	dehydrogenase complex catalyzes the overall conversion of
E7Y32_10980	COG0567	Dehydrogenase, E1 component
E7Y32_11005	COG1121	(ABC) transporter
E7Y32_11010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E7Y32_11020	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E7Y32_11045	COG1064	alcohol dehydrogenase
E7Y32_11050	COG0537	adenosine 5'-monophosphoramidase activity
E7Y32_11055	COG1643	Atp-dependent helicase
E7Y32_11090	COG0018	arginyl-trna synthetase
E7Y32_11095	COG0019	diaminopimelate decarboxylase activity
E7Y32_11100	COG0460	homoserine dehydrogenase
E7Y32_11105	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E7Y32_11110	COG0083	homoserine kinase activity
E7Y32_11120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E7Y32_11125	COG2890	protein-(glutamine-N5) methyltransferase activity
E7Y32_11135	COG1216	Glycosyl transferase, family 2
E7Y32_11145	COG1086	Polysaccharide biosynthesis protein
E7Y32_11165	COG0356	it plays a direct role in the translocation of protons across the membrane
E7Y32_11170	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E7Y32_11175	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E7Y32_11180	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E7Y32_11185	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E7Y32_11190	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E7Y32_11195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E7Y32_11200	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E7Y32_11210	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E7Y32_11215	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E7Y32_11225	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E7Y32_11230	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
E7Y32_11260	COG1902	pentaerythritol trinitrate reductase activity
E7Y32_11275	COG0363	glucosamine-6-phosphate deaminase activity
E7Y32_11295	COG1335	isochorismatase
E7Y32_11305	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E7Y32_11315	COG2203	Gaf domain
E7Y32_11315	COG2199	diguanylate cyclase activity
E7Y32_11315	COG2200	EAL domain
E7Y32_11325	COG1234	tRNA 3'-trailer cleavage
E7Y32_11330	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E7Y32_11335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E7Y32_11340	COG0586	Pfam SNARE associated Golgi protein
E7Y32_11360	COG2149	membrane
E7Y32_11370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E7Y32_11375	COG0420	3'-5' exonuclease activity
E7Y32_11380	COG0419	ATPase involved in DNA repair
E7Y32_11400	COG0477	Major facilitator Superfamily
E7Y32_11410	COG0508	dehydrogenase complex catalyzes the overall conversion of
E7Y32_11415	COG0022	dehydrogenase e1 component
E7Y32_11425	COG1113	amino acid transport
E7Y32_11440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E7Y32_11445	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E7Y32_11455	COG1104	cysteine desulfurase activity
E7Y32_11470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E7Y32_11480	COG1305	Transglutaminase-like
E7Y32_11490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E7Y32_11495	COG2814	Major facilitator Superfamily
E7Y32_11505	COG0579	oxidoreductase
E7Y32_11510	COG0747	negative chemotaxis
E7Y32_11540	COG0640	Transcriptional regulator
E7Y32_11590	COG0228	four-way junction DNA binding
E7Y32_11600	COG0129	dihydroxy-acid dehydratase activity
E7Y32_11610	COG0440	acetolactate synthase activity
E7Y32_11615	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E7Y32_11620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E7Y32_11630	COG0577	efflux transmembrane transporter activity
E7Y32_11630	COG1136	(ABC) transporter
E7Y32_11650	COG0473	3-isopropylmalate dehydrogenase activity
E7Y32_11655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E7Y32_11670	COG0179	Fumarylacetoacetate (FAA) hydrolase
E7Y32_11675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E7Y32_11715	COG1414	Transcriptional regulator
E7Y32_11720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E7Y32_11725	COG0066	3-isopropylmalate dehydratase activity
E7Y32_11740	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E7Y32_11750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E7Y32_11755	COG1181	Belongs to the D-alanine--D-alanine ligase family
E7Y32_11765	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E7Y32_11770	COG1088	dTDP-glucose 4,6-dehydratase activity
E7Y32_11785	COG1461	Dihydroxyacetone kinase
E7Y32_11795	COG0742	ribosomal rna small subunit methyltransferase
E7Y32_11810	COG0300	oxidoreductase activity
E7Y32_11815	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E7Y32_11825	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E7Y32_11835	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E7Y32_11850	COG2814	Major facilitator Superfamily
E7Y32_11865	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E7Y32_11880	COG2514	catechol 2,3-dioxygenase activity
E7Y32_11890	COG0228	four-way junction DNA binding
E7Y32_11895	COG1837	Belongs to the UPF0109 family
E7Y32_11900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E7Y32_11905	COG0336	Belongs to the RNA methyltransferase TrmD family
E7Y32_11910	COG0335	large ribosomal subunit rRNA binding
E7Y32_11915	COG0681	Belongs to the peptidase S26 family
E7Y32_11925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E7Y32_11935	COG0792	nuclease activity
E7Y32_11940	COG0606	chelatase, subunit chli
E7Y32_11950	COG4974	Belongs to the 'phage' integrase family
E7Y32_11965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E7Y32_11970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E7Y32_11985	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E7Y32_12020	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E7Y32_12030	COG1045	serine acetyltransferase
E7Y32_12040	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E7Y32_12045	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E7Y32_12055	COG3022	response to hydroperoxide
E7Y32_12105	COG2326	polyphosphate kinase activity
E7Y32_12110	COG0242	peptide deformylase activity
E7Y32_12115	COG1960	acyl-CoA dehydrogenase activity
E7Y32_12145	COG5416	Lipopolysaccharide assembly protein A domain
E7Y32_12150	COG0598	Magnesium transport protein CorA
E7Y32_12170	COG1946	Acyl-CoA thioesterase
E7Y32_12180	COG0456	acetyltransferase
E7Y32_12190	COG0668	transmembrane transport
E7Y32_12235	COG0544	peptidyl-prolyl cis-trans isomerase activity
E7Y32_12240	COG0740	serine-type endopeptidase activity
E7Y32_12245	COG0740	serine-type endopeptidase activity
E7Y32_12250	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E7Y32_12255	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E7Y32_12260	COG3387	PFAM Glycoside hydrolase 15-related
E7Y32_12265	COG0525	valine-tRNA ligase activity
E7Y32_12270	COG3189	MarR family transcriptional regulator
E7Y32_12280	COG0584	glycerophosphoryl diester phosphodiesterase
E7Y32_12285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E7Y32_12290	COG0285	dihydrofolate synthase activity
E7Y32_12300	COG0105	UTP biosynthetic process
E7Y32_12310	COG1530	ribonuclease E activity
E7Y32_12315	COG0352	thiamine-phosphate diphosphorylase activity
E7Y32_12315	COG0351	phosphomethylpyrimidine kinase
E7Y32_12315	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E7Y32_12320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E7Y32_12325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E7Y32_12330	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E7Y32_12335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E7Y32_12340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E7Y32_12350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E7Y32_12360	COG0799	negative regulation of ribosome biogenesis
E7Y32_12375	COG0492	ferredoxin-NADP+ reductase activity
E7Y32_12380	COG2890	protein-(glutamine-N5) methyltransferase activity
E7Y32_12400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E7Y32_12410	COG1012	belongs to the aldehyde dehydrogenase family
E7Y32_12435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E7Y32_12445	COG1780	Probably involved in ribonucleotide reductase function
E7Y32_12450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E7Y32_12460	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E7Y32_12480	COG3384	dioxygenase
E7Y32_12490	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_12520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E7Y32_12525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E7Y32_12550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E7Y32_12555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E7Y32_12565	COG0730	response to heat
E7Y32_12575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E7Y32_12600	COG1595	DNA-templated transcription, initiation
E7Y32_12625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E7Y32_12675	COG0569	domain protein
E7Y32_12675	COG0475	glutathione-regulated potassium exporter activity
E7Y32_12685	COG2205	protein histidine kinase activity
E7Y32_12690	COG0745	RESPONSE REGULATOR receiver
E7Y32_12695	COG0586	Pfam SNARE associated Golgi protein
E7Y32_12700	COG0671	phosphoesterase, PA-phosphatase related
E7Y32_12705	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E7Y32_12710	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E7Y32_12750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E7Y32_12760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E7Y32_12765	COG0509	glycine decarboxylation via glycine cleavage system
E7Y32_12770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E7Y32_12775	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E7Y32_12775	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E7Y32_12780	COG1113	amino acid transport
E7Y32_12800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E7Y32_12815	COG2135	peptidase activity
E7Y32_12825	COG1605	Chorismate mutase
E7Y32_12825	COG0077	Prephenate dehydratase
E7Y32_12840	COG0587	DNA-directed DNA polymerase activity
E7Y32_12845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E7Y32_12860	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E7Y32_12890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E7Y32_12895	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
E7Y32_12900	COG0217	transcriptional regulatory protein
E7Y32_12905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E7Y32_12910	COG0632	four-way junction helicase activity
E7Y32_12915	COG2255	four-way junction helicase activity
E7Y32_12925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E7Y32_12930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E7Y32_12935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E7Y32_12945	COG1196	nuclear chromosome segregation
E7Y32_12955	COG0124	histidyl-tRNA synthetase
E7Y32_12965	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E7Y32_12970	COG0456	acetyltransferase
E7Y32_12985	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E7Y32_13000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E7Y32_13005	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E7Y32_13015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E7Y32_13020	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E7Y32_13025	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E7Y32_13030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E7Y32_13040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E7Y32_13045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E7Y32_13055	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E7Y32_13060	COG0540	Belongs to the ATCase OTCase family
E7Y32_13065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E7Y32_13075	COG0505	Belongs to the CarA family
E7Y32_13080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E7Y32_13085	COG0284	orotidine-5'-phosphate decarboxylase activity
E7Y32_13090	COG0194	GDP metabolic process
E7Y32_13095	COG0194	GDP metabolic process
E7Y32_13100	COG1758	RNA polymerase activity
E7Y32_13110	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E7Y32_13120	COG0297	glycogen (starch) synthase activity
E7Y32_13130	COG0656	L-ascorbic acid biosynthetic process
E7Y32_13140	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E7Y32_13145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E7Y32_13150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E7Y32_13160	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E7Y32_13175	COG0495	leucyl-tRNA aminoacylation
E7Y32_13180	COG1307	EDD domain protein, DegV family
E7Y32_13185	COG2183	response to ionizing radiation
E7Y32_13200	COG0268	Binds directly to 16S ribosomal RNA
E7Y32_13210	COG0481	GTPase activity
E7Y32_13215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E7Y32_13230	COG1420	regulation of RNA biosynthetic process
E7Y32_13235	COG0484	heat shock protein binding
E7Y32_13240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E7Y32_13255	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E7Y32_13265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E7Y32_13270	COG1316	TRANSCRIPTIONal
E7Y32_13280	COG3590	peptidase
E7Y32_13285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E7Y32_13290	COG1381	Involved in DNA repair and RecF pathway recombination
E7Y32_13295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E7Y32_13310	COG0167	dihydroorotate dehydrogenase activity
E7Y32_13320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E7Y32_13330	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E7Y32_13335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E7Y32_13345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E7Y32_13350	COG2188	Transcriptional regulator
E7Y32_13355	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E7Y32_13360	COG0723	plastoquinol--plastocyanin reductase activity
E7Y32_13365	COG2010	Cytochrome c
E7Y32_13370	COG1845	cytochrome c oxidase, subunit III
E7Y32_13375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E7Y32_13405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E7Y32_13410	COG3424	synthase
E7Y32_13435	COG0242	peptide deformylase activity
E7Y32_13440	COG4946	Tricorn protease homolog
E7Y32_13440	COG1506	peptidase
E7Y32_13440	COG0823	Involved in the tonB-independent uptake of proteins
E7Y32_13465	COG1216	Glycosyl transferase, family 2
E7Y32_13470	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E7Y32_13475	COG4581	dead DEAH box helicase
E7Y32_13480	COG0805	protein transport
E7Y32_13485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E7Y32_13505	COG0545	Peptidyl-prolyl cis-trans isomerase
E7Y32_13510	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
E7Y32_13515	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
E7Y32_13520	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
E7Y32_13530	COG4122	O-methyltransferase activity
E7Y32_13535	COG1222	aaa ATPase
E7Y32_13545	COG1994	Peptidase M50
E7Y32_13545	COG0517	IMP dehydrogenase activity
E7Y32_13560	COG0215	cysteine-tRNA ligase activity
E7Y32_13565	COG1968	undecaprenyl-diphosphatase activity
E7Y32_13570	COG0656	L-ascorbic acid biosynthetic process
E7Y32_13595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E7Y32_13640	COG0435	Glutathione S-transferase
E7Y32_13655	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_13660	COG0183	Belongs to the thiolase family
E7Y32_13675	COG0297	glycogen (starch) synthase activity
E7Y32_13680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E7Y32_13725	COG2308	Evidence 4 Homologs of previously reported genes of
E7Y32_13730	COG2855	membrane
E7Y32_13740	COG0095	Lipoate-protein ligase
E7Y32_13745	COG0254	rRNA binding
E7Y32_13760	COG1119	ATPase activity
E7Y32_13765	COG0560	Phosphoserine phosphatase
E7Y32_13765	COG3830	Belongs to the UPF0237 family
E7Y32_13770	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_13780	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_13805	COG0488	(ABC) transporter
E7Y32_13810	COG1268	BioY protein
E7Y32_13815	COG1122	ATPase activity
E7Y32_13825	COG0183	Belongs to the thiolase family
E7Y32_13830	COG0318	PFAM AMP-dependent synthetase and ligase
E7Y32_13840	COG2151	metal-sulfur cluster biosynthetic enzyme
E7Y32_13845	COG0396	ATPase activity
E7Y32_13870	COG1131	(ABC) transporter
E7Y32_13880	COG1612	heme a metabolic process
E7Y32_13890	COG0109	protoheme IX farnesyltransferase activity
E7Y32_13900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E7Y32_13905	COG0166	Belongs to the GPI family
E7Y32_13920	COG0363	glucosamine-6-phosphate deaminase activity
E7Y32_13930	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E7Y32_13935	COG0149	triose-phosphate isomerase activity
E7Y32_13940	COG0126	phosphoglycerate kinase activity
E7Y32_13945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E7Y32_13950	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E7Y32_13955	COG1481	regulation of sporulation
E7Y32_13960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E7Y32_13965	COG1660	Displays ATPase and GTPase activities
E7Y32_13970	COG0322	excinuclease ABC activity
E7Y32_14000	COG1132	(ABC) transporter
E7Y32_14005	COG4106	trans-aconitate 2-methyltransferase activity
E7Y32_14010	COG0400	carboxylic ester hydrolase activity
E7Y32_14040	COG0861	Integral membrane protein TerC family
E7Y32_14045	COG0556	nucleotide-excision repair
E7Y32_14050	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E7Y32_14050	COG0237	dephospho-CoA kinase activity
E7Y32_14055	COG1739	Uncharacterized protein family UPF0029
E7Y32_14070	COG0539	negative regulation of cytoplasmic translation
E7Y32_14080	COG4552	Acetyltransferase involved in intracellular survival and related
E7Y32_14090	COG2050	protein possibly involved in aromatic compounds catabolism
E7Y32_14095	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E7Y32_14110	COG0589	response to stress
E7Y32_14120	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E7Y32_14125	COG0318	PFAM AMP-dependent synthetase and ligase
E7Y32_14135	COG2132	Multicopper oxidase
E7Y32_14175	COG3608	succinylglutamate desuccinylase aspartoacylase
E7Y32_14175	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E7Y32_14185	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E7Y32_14200	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E7Y32_14200	COG3608	succinylglutamate desuccinylase aspartoacylase
E7Y32_14205	COG2249	NAD(P)H dehydrogenase (quinone) activity
E7Y32_14210	COG1028	Short-chain dehydrogenase reductase Sdr
E7Y32_14215	COG0009	L-threonylcarbamoyladenylate synthase
E7Y32_14225	COG2226	methyltransferase
E7Y32_14245	COG0586	Pfam SNARE associated Golgi protein
E7Y32_14265	COG2205	protein histidine kinase activity
E7Y32_14270	COG0745	RESPONSE REGULATOR receiver
E7Y32_14280	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E7Y32_14285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E7Y32_14310	COG1643	Atp-dependent helicase
E7Y32_14320	COG1064	alcohol dehydrogenase
E7Y32_14325	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E7Y32_14340	COG1733	regulation of RNA biosynthetic process
E7Y32_14345	COG0702	epimerase
E7Y32_14355	COG0405	Gamma-glutamyltransferase
E7Y32_14365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E7Y32_14370	COG2814	Major facilitator Superfamily
E7Y32_14385	COG0179	Fumarylacetoacetate (FAA) hydrolase
E7Y32_14395	COG1309	transcriptional regulator
E7Y32_14430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E7Y32_14440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E7Y32_14450	COG0640	Transcriptional regulator
E7Y32_14465	COG0277	FAD linked oxidase domain protein
E7Y32_14470	COG1620	l-lactate permease
E7Y32_14475	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E7Y32_14490	COG1695	Transcriptional regulator
E7Y32_14495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E7Y32_14545	COG1473	amidohydrolase
E7Y32_14565	COG0469	pyruvate kinase activity
E7Y32_14575	COG0070	glutamate synthase
E7Y32_14575	COG0067	glutamate synthase
E7Y32_14575	COG0069	glutamate synthase activity
E7Y32_14580	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E7Y32_14585	COG0159	tryptophan synthase activity
E7Y32_14590	COG0133	tryptophan synthase activity
E7Y32_14595	COG0134	indole-3-glycerol-phosphate synthase activity
E7Y32_14615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E7Y32_14630	COG0596	Alpha beta hydrolase
E7Y32_14635	COG0107	imidazoleglycerol-phosphate synthase activity
E7Y32_14640	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E7Y32_14645	COG0140	phosphoribosyl-ATP diphosphatase activity
E7Y32_14650	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E7Y32_14660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E7Y32_14660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E7Y32_14675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E7Y32_14685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E7Y32_14690	COG0242	peptide deformylase activity
E7Y32_14750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E7Y32_14765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E7Y32_14790	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E7Y32_14795	COG0183	Belongs to the thiolase family
E7Y32_14800	COG1024	Enoyl-CoA hydratase
E7Y32_14800	COG1250	3-hydroxyacyl-CoA dehydrogenase
E7Y32_14810	COG3845	ABC transporter
E7Y32_14830	COG0667	Aldo Keto reductase
E7Y32_14845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E7Y32_14850	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E7Y32_14855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E7Y32_14860	COG0531	amino acid
E7Y32_14865	COG0569	domain protein
E7Y32_14890	COG0756	dUTP diphosphatase activity
E7Y32_14920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E7Y32_14920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E7Y32_14925	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E7Y32_14940	COG0456	acetyltransferase
E7Y32_14945	COG4988	ABC transporter
E7Y32_14950	COG1294	oxidase, subunit
E7Y32_14955	COG1271	oxidase subunit
E7Y32_14980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E7Y32_15000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E7Y32_15005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E7Y32_15010	COG0508	dehydrogenase complex catalyzes the overall conversion of
E7Y32_15020	COG1764	response to oxidative stress
E7Y32_15025	COG4946	Tricorn protease homolog
E7Y32_15025	COG0793	Belongs to the peptidase S41A family
E7Y32_15030	COG1090	epimerase
E7Y32_15040	COG0321	lipoyl(octanoyl) transferase activity
E7Y32_15045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E7Y32_15075	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E7Y32_15080	COG0174	glutamine synthetase
E7Y32_15085	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E7Y32_15090	COG2353	YceI-like domain
E7Y32_15110	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E7Y32_15115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E7Y32_15145	COG3599	regulation of cell shape
E7Y32_15155	COG1799	cell septum assembly
E7Y32_15170	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E7Y32_15180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E7Y32_15185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E7Y32_15190	COG0772	Belongs to the SEDS family
E7Y32_15195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E7Y32_15200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E7Y32_15215	COG0768	penicillin binding
E7Y32_15225	COG0275	rRNA processing
E7Y32_15230	COG2001	Belongs to the MraZ family
E7Y32_15250	COG0142	geranyltranstransferase activity
E7Y32_15260	COG1388	LysM domain
E7Y32_15260	COG3942	CHAP domain
E7Y32_15265	COG2815	serine threonine protein kinase
E7Y32_15265	COG0515	serine threonine protein kinase
E7Y32_15295	COG1940	carbohydrate kinase activity
E7Y32_15310	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E7Y32_15340	COG0509	glycine decarboxylation via glycine cleavage system
E7Y32_15345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E7Y32_15355	COG1160	GTP binding
E7Y32_15365	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E7Y32_15380	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E7Y32_15385	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E7Y32_15395	COG1301	dicarboxylic acid transport
E7Y32_15400	COG3290	protein histidine kinase activity
E7Y32_15420	COG2079	MmgE PrpD family protein
E7Y32_15425	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E7Y32_15450	COG1595	DNA-templated transcription, initiation
E7Y32_15475	COG0504	CTP synthase activity
E7Y32_15480	COG0497	DNA recombination
E7Y32_15485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E7Y32_15500	COG0647	UMP catabolic process
E7Y32_15525	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E7Y32_15535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E7Y32_15545	COG2094	Belongs to the DNA glycosylase MPG family
E7Y32_15555	COG2169	Transcriptional regulator
E7Y32_15555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E7Y32_15565	COG0259	pyridoxamine-phosphate oxidase activity
E7Y32_15570	COG0165	Argininosuccinate lyase
E7Y32_15575	COG0137	argininosuccinate synthase activity
E7Y32_15580	COG1438	arginine binding
E7Y32_15585	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E7Y32_15590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E7Y32_15595	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E7Y32_15605	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E7Y32_15635	COG0072	phenylalanine-tRNA ligase activity
E7Y32_15635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E7Y32_15640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E7Y32_15655	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E7Y32_15665	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E7Y32_15670	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E7Y32_15675	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E7Y32_15685	COG2814	Major facilitator Superfamily
E7Y32_15695	COG2261	transglycosylase associated protein
E7Y32_15700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E7Y32_15705	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E7Y32_15710	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E7Y32_15715	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E7Y32_15735	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E7Y32_15740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E7Y32_15745	COG0131	Imidazoleglycerol-phosphate dehydratase
E7Y32_15750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E7Y32_15760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E7Y32_15770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E7Y32_15775	COG2813	Specifically methylates the guanine in position
E7Y32_15780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E7Y32_15785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E7Y32_15790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E7Y32_15795	COG2137	regulation of response to DNA damage stimulus
E7Y32_15800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E7Y32_15815	COG1396	sequence-specific DNA binding
E7Y32_15820	COG1546	Belongs to the CinA family
E7Y32_15820	COG1058	Belongs to the CinA family
E7Y32_15830	COG1674	ftsk spoiiie
E7Y32_15835	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E7Y32_15840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E7Y32_15850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E7Y32_15865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E7Y32_15875	COG0521	Mo-molybdopterin cofactor biosynthetic process
E7Y32_15915	COG0318	PFAM AMP-dependent synthetase and ligase
E7Y32_15925	COG0559	Belongs to the binding-protein-dependent transport system permease family
E7Y32_15930	COG0410	ABC transporter
E7Y32_15935	COG0411	ABC transporter
E7Y32_15950	COG0612	Peptidase, M16
E7Y32_15955	COG1185	polyribonucleotide nucleotidyltransferase activity
E7Y32_15960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E7Y32_15970	COG3483	tryptophan 2,3-dioxygenase activity
E7Y32_16030	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E7Y32_16050	COG3118	belongs to the thioredoxin family
E7Y32_16055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E7Y32_16060	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E7Y32_16075	COG0779	Required for maturation of 30S ribosomal subunits
E7Y32_16090	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
E7Y32_16105	COG0442	prolyl-tRNA aminoacylation
E7Y32_16115	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E7Y32_16135	COG0750	zinc metalloprotease
E7Y32_16140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E7Y32_16160	COG3290	protein histidine kinase activity
E7Y32_16165	COG4565	transcriptional regulatory protein
E7Y32_16190	COG1960	acyl-CoA dehydrogenase activity