locus-tag class description ATC04_00130 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ATC04_00140 ENOG4105CRK lysyL-tRNA synthetase ATC04_00145 ENOG4105C9K Endothelin-converting enzyme 1 ATC04_00150 ENOG4108QIU Dehydrogenase ATC04_00200 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) ATC04_00235 ENOG4105EUJ GTP cyclohydrolase i ATC04_00240 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ATC04_00250 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) ATC04_00260 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family ATC04_00265 ENOG4105F0N pyrophosphate phospho-hydrolase ATC04_00275 ENOG4107QSV RmuC domain protein ATC04_00305 ENOG4108X4Q Hydrolase ATC04_00310 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) ATC04_00315 ENOG4107TE5 Lipid kinase ATC04_00335 ENOG4105DUX Transporter ATC04_00340 ENOG4105VMP Transcriptional regulator ATC04_00355 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 ATC04_00360 ENOG4108IQI permease ATC04_00365 ENOG4105C26 Dehydrogenase ATC04_00380 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase ATC04_00385 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) ATC04_00390 ENOG4105DWF phosphomethylpyrimidine kinase ATC04_00395 ENOG4105C2W permease ATC04_00410 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein ATC04_00415 ENOG4105CSH Transporter ATC04_00425 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein ATC04_00430 ENOG4107HP6 Transcriptional regulator ATC04_00455 ENOG4108K4B hydrolase ATC04_00460 ENOG4105D7K pfkb domain protein ATC04_00470 ENOG4105E39 Enoyl-CoA hydratase ATC04_00485 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) ATC04_00490 ENOG4105DU0 nucleoside hydrolase ATC04_00495 ENOG4105ETE Transcriptional regulator (LacI family ATC04_00520 ENOG4105HZM Fha domain containing protein ATC04_00540 ENOG4107TPY serine threonine protein kinase ATC04_00545 ENOG4105D9P serine threonine protein kinase ATC04_00555 ENOG4108U4N (sortase) family ATC04_00560 ENOG4105ZJT Cell division protein CrgA ATC04_00565 ENOG4105KPY Small multidrug resistance protein ATC04_00570 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) ATC04_00585 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) ATC04_00600 ENOG4105C09 Bile acid ATC04_00620 ENOG4108ZED Transmembrane domain of unknown function (DUF3566) ATC04_00625 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ATC04_00630 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ATC04_00635 ENOG4105K7N UPF0232 protein ATC04_00640 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) ATC04_00645 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ATC04_00650 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) ATC04_00660 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) ATC04_00665 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins ATC04_00675 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) ATC04_00680 ENOG4107QJE Chromosome Partitioning Protein ATC04_00685 ENOG4105FA0 parb-like partition protein ATC04_00690 ENOG4105K63 Thioredoxin ATC04_00695 ENOG4105C3M thioredoxin reductase ATC04_00715 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate ATC04_00720 ENOG4105CZA synthase ATC04_00745 ENOG4105D2T synthase ATC04_00750 ENOG4105F0R Cytidylyltransferase ATC04_00780 ENOG4105BZU Histidine kinase ATC04_00785 ENOG4105WH1 Two component transcriptional regulator luxr family ATC04_00795 ENOG4105DFM M18 family aminopeptidase ATC04_00810 ENOG4105D5U fad dependent oxidoreductase ATC04_00815 ENOG4105EXC Acyl-transferase ATC04_00820 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) ATC04_00830 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) ATC04_00835 ENOG4105K9Q Binds to the 23S rRNA (By similarity) ATC04_00885 ENOG4105CEY Amp-dependent synthetase and ligase ATC04_00930 ENOG4105CDU Replicative dna helicase ATC04_00940 ENOG4105C57 major facilitator superfamily ATC04_00955 ENOG4105EUB pirin domain protein ATC04_00960 ENOG4105K56 Transcriptional regulator ATC04_00975 ENOG41061TZ Short-chain dehydrogenase reductase Sdr ATC04_01010 ENOG4105VT2 5-hydroxyisourate hydrolase ATC04_01020 ENOG4105C2W permease ATC04_01025 ENOG4105ETE Transcriptional regulator (LacI family ATC04_01040 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) ATC04_01045 ENOG4105DFW ABC transporter ATC04_01055 ENOG4107RNG ABC transporter ATC04_01060 ENOG4107WI4 Aldose-1-epimerase ATC04_01070 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) ATC04_01095 ENOG4105CUB amino acid ATC04_01115 ENOG4105EMU Dehydrogenase ATC04_01130 ENOG4105DXB Major Facilitator superfamily ATC04_01135 ENOG4105C85 amino acid ATC04_01145 ENOG4105DKQ ROK family ATC04_01160 ENOG4105BZ1 (ABC) transporter ATC04_01165 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein ATC04_01185 ENOG4107R9S Malate synthase ATC04_01195 ENOG4105S0E allantoin catabolism protein ATC04_01210 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase ATC04_01225 ENOG41088PD hydrolase ATC04_01230 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ATC04_01255 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ATC04_01260 ENOG4105CEY Amp-dependent synthetase and ligase ATC04_01290 ENOG4108RZE Tetr family transcriptional regulator ATC04_01295 ENOG4105D74 hydrolase ATC04_01305 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ATC04_01320 ENOG4105CHR reductase ATC04_01335 ENOG4105CHU acetyl-coa acetyltransferase ATC04_01365 ENOG4105C0R drug resistance transporter emrb qaca subfamily ATC04_01375 ENOG4105CHR reductase ATC04_01385 ENOG4105C32 Amino acid ABC transporter (Permease) ATC04_01390 ENOG4105C0Z ABC transporter ATC04_01395 ENOG4108IV0 ABC, transporter ATC04_01405 ENOG4105CHU acetyl-coa acetyltransferase ATC04_01430 ENOG4108KC2 acyl-Coa dehydrogenase ATC04_01435 ENOG4105D2B acyl-CoA dehydrogenase ATC04_01440 ENOG4105D2B acyl-CoA dehydrogenase ATC04_01450 ENOG4105CC9 acyl-Coa dehydrogenase ATC04_01460 ENOG4105F2C Acetyl-CoA acetyltransferase ATC04_01480 ENOG4105EA8 2-Nitropropane dioxygenase ATC04_01495 ENOG4105E39 Enoyl-CoA hydratase ATC04_01515 ENOG4105C10 Electron transfer flavoprotein ATC04_01545 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) ATC04_01550 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) ATC04_01555 ENOG4105IKQ hydratase ATC04_01560 ENOG41069M3 Transcriptional regulator ATC04_01565 ENOG4105KAK Plasmid pRiA4b ORF-3 family protein ATC04_01580 ENOG4105C10 Electron transfer flavoprotein ATC04_01590 ENOG41073TP transcriptional regulator ATC04_01595 ENOG4105DEF Extracellular solute-binding protein, family 5 ATC04_01600 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ATC04_01605 ENOG4105C3U ABC transporter ATC04_01610 ENOG4108JQ7 (ABC) transporter ATC04_01615 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ATC04_01620 ENOG4105DKQ ROK family ATC04_01625 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) ATC04_01655 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) ATC04_01670 ENOG4105DUM transcriptional regulator, lysR family ATC04_01675 ENOG4105E2A Dehydrogenase ATC04_01685 ENOG4107258 Transcriptional regulator ATC04_01690 ENOG4105CSH Transporter ATC04_01695 ENOG4105CSH Transporter ATC04_01705 ENOG4105C94 Transporter ATC04_01725 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ATC04_01775 ENOG4105CEY Amp-dependent synthetase and ligase ATC04_01790 ENOG4108NJZ Sensory box GGDEF EAL domain protein ATC04_01795 ENOG4105BZU Histidine kinase ATC04_01800 ENOG4105CHH sulfate transporter ATC04_01815 ENOG4105BZW Glycerate kinase ATC04_01870 ENOG4107QX3 carboxylase ATC04_01890 ENOG4105CG3 alpha amylase, catalytic region ATC04_01895 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component ATC04_01900 ENOG4105D56 permease protein ATC04_01925 ENOG4108IPW abc transporter atp-binding protein ATC04_01930 ENOG4105CM4 permease protein ATC04_01940 ENOG4108MES Periplasmic binding protein ATC04_01965 ENOG4105VEQ Cold shock protein ATC04_01980 ENOG410633P Hydantoin racemase ATC04_01985 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease ATC04_01990 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) ATC04_01995 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ATC04_02000 ENOG41060W2 glyoxylate carboligase ATC04_02015 ENOG4107S2Z UPF0761 membrane protein ATC04_02035 ENOG4107ZR7 Membrane ATC04_02050 ENOG4108FKE two-component system sensor kinase ATC04_02055 ENOG4108PYU two-component system response regulator ATC04_02065 ENOG4105EXC Acyl-transferase ATC04_02105 ENOG4105CSV Glutaminase ATC04_02130 ENOG4105CHR reductase ATC04_02140 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) ATC04_02150 ENOG4107258 Transcriptional regulator ATC04_02170 ENOG4105DEN Luciferase family ATC04_02175 ENOG4105CKU formyltetrahydrofolate synthetase ATC04_02205 ENOG4108JJB ABC transporter ATC04_02290 ENOG4105G9B Transcriptional regulator ATC04_02300 ENOG4105CSH Transporter ATC04_02305 ENOG4105DUM transcriptional regulator, lysR family ATC04_02315 ENOG4105C7K acetolactate synthase ATC04_02320 ENOG4105C26 Dehydrogenase ATC04_02345 ENOG4105CVP deoxyribo-dipyrimidine photolyase ATC04_02360 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) ATC04_02370 ENOG4105C26 Dehydrogenase ATC04_02380 ENOG4105DQE DNA ligase ATC04_02385 ENOG4105FDF Could be involved in DNA repair (By similarity) ATC04_02400 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ATC04_02425 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) ATC04_02435 ENOG4107RY6 amino acid ATC04_02440 ENOG4105H67 Protein of unknown function (DUF421) ATC04_02450 ENOG4108ZCD Transcriptional coactivator pterin dehydratase ATC04_02465 ENOG4107R3N Filamentation induced by cAMP protein fic ATC04_02475 ENOG4105D0M Protease HtpX homolog ATC04_02505 ENOG4105D2B acyl-CoA dehydrogenase ATC04_02510 ENOG4105CD5 CoA-binding domain protein ATC04_02515 ENOG4108SGK Tetr family transcriptional regulator ATC04_02535 ENOG4105C26 Dehydrogenase ATC04_02580 ENOG4105X7H acyl-CoA dehydrogenase ATC04_02585 ENOG4108RK3 acyl-Coa dehydrogenase ATC04_02600 ENOG410900P UPF0336 protein ATC04_02630 ENOG4105C10 Electron transfer flavoprotein ATC04_02640 ENOG4105CN8 Transcriptional regulator ATC04_02655 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ATC04_02665 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ATC04_02670 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ATC04_02675 ENOG4105DEF Extracellular solute-binding protein, family 5 ATC04_02685 ENOG4108TYN CAAX amino terminal protease family protein ATC04_02690 ENOG4105D94 Major Facilitator Superfamily ATC04_02700 ENOG4105UQX Mate efflux family protein ATC04_02710 ENOG4105CSH Transporter ATC04_02730 ENOG4105CUB amino acid ATC04_02735 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) ATC04_02755 ENOG4105KZX Pterin carbinolamine dehydratase ATC04_02760 ENOG4107QTZ amino acid ATC04_02765 ENOG4105NAE bifunctional deaminase-reductase domain protein ATC04_02775 ENOG4105C85 amino acid ATC04_02785 ENOG4105ME7 Membrane ATC04_02805 ENOG4105VPX protein, conserved in bacteria ATC04_02835 ENOG4105DJ2 Major Facilitator Superfamily ATC04_02860 ENOG4105QPS Monooxygenase ATC04_02900 ENOG4105BZU Histidine kinase ATC04_02925 ENOG4105NAU thioesterase Superfamily protein ATC04_02930 ENOG4105CSV Glutaminase ATC04_02970 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase ATC04_02975 ENOG4105DWY Agmatine deiminase ATC04_03015 ENOG4105DXX methyltransferase ATC04_03020 ENOG4105QPS Monooxygenase ATC04_03025 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs ATC04_03040 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) ATC04_03045 ENOG4105CHM Aminotransferase ATC04_03060 ENOG4105CI2 imidazolone-5-propionate hydrolase ATC04_03085 ENOG4108M15 ABC transporter ATC04_03095 ENOG4105BZU Histidine kinase ATC04_03115 ENOG4105CEY Amp-dependent synthetase and ligase ATC04_03130 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ATC04_03140 ENOG4105C2W permease ATC04_03160 ENOG4105CQB FAD linked oxidase domain protein ATC04_03170 ENOG4105CPC Aldo Keto reductase ATC04_03180 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ATC04_03185 ENOG4107QZF nitrite reductase NADPH large subunit ATC04_03200 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ATC04_03205 ENOG4107QND Nitrite extrusion protein ATC04_03215 ENOG4107QTF adenylosuccinate lyase ATC04_03235 ENOG41082T9 Membrane ATC04_03240 ENOG4105CIH Imidazole acetol-phosphate transaminase ATC04_03250 ENOG4105CPP Dehydrogenase, E1 component ATC04_03255 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 ATC04_03260 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein ATC04_03270 ENOG4108IJ0 Aspartate ammonia-lyase ATC04_03280 ENOG4107YCY Transcriptional regulator ATC04_03295 ENOG4105C7K acetolactate synthase ATC04_03300 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ATC04_03305 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) ATC04_03320 ENOG4105CHU acetyl-coa acetyltransferase ATC04_03340 ENOG4107258 Transcriptional regulator ATC04_03395 ENOG4105C0R drug resistance transporter emrb qaca subfamily ATC04_03410 ENOG4105CEY Amp-dependent synthetase and ligase ATC04_03430 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ATC04_03440 ENOG4105DEF Extracellular solute-binding protein, family 5 ATC04_03450 ENOG4105KVH Transcriptional regulator ATC04_03455 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) ATC04_03460 ENOG4105CSH Transporter ATC04_03470 ENOG4105JP4 Inner membrane protein yidG ATC04_03475 ENOG4105VG5 Membrane ATC04_03480 ENOG4105C1G acyl-Coa dehydrogenase ATC04_03495 ENOG4107ZR7 Membrane ATC04_03500 ENOG4108M0I Transcriptional regulator ATC04_03510 ENOG4108R4R Iron-regulated virulence regulatory protein ATC04_03525 ENOG4105CSH Transporter ATC04_03530 ENOG4107S9B Shikimate dehydrogenase ATC04_03535 ENOG4107TRN Xylose isomerase domain protein TIM barrel ATC04_03540 ENOG4107HP6 Transcriptional regulator ATC04_03545 ENOG4108ZJI phenylacetic acid degradation protein ATC04_03555 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ATC04_03590 ENOG4105CI0 Citrate lyase ATC04_03595 ENOG4105BZG amino acid carrier protein ATC04_03600 ENOG4105ERH Fumarylacetoacetate hydrolase ATC04_03605 ENOG4105E90 ABC transporter ATC04_03610 ENOG4108IJ8 ABC transporter ATC04_03615 ENOG4105E90 ABC transporter ATC04_03640 ENOG41080R8 Conserved Protein ATC04_03645 ENOG4107QR9 Iron-sulfur cluster binding protein ATC04_03650 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ATC04_03655 ENOG4105DAA L-lactate ATC04_03660 ENOG4105FDP GntR family transcriptional regulator ATC04_03695 ENOG4105VQD rieske 2fe-2S domain-containing protein ATC04_03725 ENOG4105CZN Potassium uptake protein ATC04_03730 ENOG4107ZYR domain protein ATC04_03790 ENOG4107TXC Transcriptional regulator ATC04_03830 ENOG4105S7S phosphonate abc transporter ATC04_03850 ENOG4105CZE histidine utilization repressor ATC04_03860 ENOG4107R5H iron (metal) dependent repressor, dtxr family ATC04_03865 ENOG4108RVA ribokinase ATC04_03885 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) ATC04_03890 ENOG4105C84 Histidine ammonia-lyase ATC04_03915 ENOG4105CHR reductase ATC04_03925 ENOG4105DIA mandelate racemase muconate lactonizing ATC04_03950 ENOG4105CNN ABC, transporter ATC04_03955 ENOG4105D4B ABC, transporter ATC04_03960 ENOG4107YCY Transcriptional regulator ATC04_03965 ENOG4108KPW sugar kinase ATC04_03970 ENOG4105CF1 Alkylated DNA repair protein ATC04_03980 ENOG4105F27 Major Facilitator ATC04_04000 ENOG4105CHR reductase ATC04_04005 ENOG4105CPQ Dehydrogenase ATC04_04030 ENOG4105KXX peptidase s58 dmpa ATC04_04070 ENOG410667J hydrolase ATC04_04095 ENOG4105CXN decarboxylase ATC04_04115 ENOG4105CK7 Sodium proline symporter ATC04_04125 ENOG4105C26 Dehydrogenase ATC04_04140 ENOG4105KV4 Transcriptional regulator ATC04_04160 ENOG4108IUX (ABC) transporter ATC04_04165 ENOG4105WH1 Two component transcriptional regulator luxr family ATC04_04170 ENOG4105BZU Histidine kinase ATC04_04180 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase ATC04_04190 ENOG4108JJ9 ABC, transporter ATC04_04195 ENOG4105BZ1 (ABC) transporter ATC04_04200 ENOG4105CBC glutamate synthase ATC04_04210 ENOG4105DUM transcriptional regulator, lysR family ATC04_04235 ENOG4105DEN Luciferase family ATC04_04240 ENOG4105VEQ Cold shock protein ATC04_04245 ENOG4105C57 major facilitator superfamily ATC04_04260 ENOG4105EN6 Membrane ATC04_04270 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein ATC04_04290 ENOG41090A1 ferritin ATC04_04300 ENOG4105WH1 Two component transcriptional regulator luxr family ATC04_04325 ENOG4105C26 Dehydrogenase ATC04_04330 ENOG4105CPC Aldo Keto reductase ATC04_04335 ENOG4105U6C Alpha beta hydrolase fold protein ATC04_04340 ENOG4105CQ7 ATP-dependent helicase ATC04_04345 ENOG4105C1G acyl-Coa dehydrogenase ATC04_04370 ENOG4105JAB phenazine biosynthesis protein, phzf family ATC04_04395 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ATC04_04410 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) ATC04_04415 ENOG4105DQ5 transport system permease protein ATC04_04420 ENOG4105TVJ transport system, permease ATC04_04425 ENOG4105E0A ABC, transporter ATC04_04435 ENOG4105BZ1 (ABC) transporter ATC04_04450 ENOG4105CHF Glutathione S-transferase ATC04_04465 ENOG4107R7I amino acid ATC04_04480 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor ATC04_04485 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) ATC04_04495 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ATC04_04505 ENOG4105CJW magnesium transporter ATC04_04510 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ATC04_04545 ENOG4105CJP fad dependent oxidoreductase ATC04_04560 ENOG4105W1N transcriptional regulator ATC04_04590 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) ATC04_04610 ENOG4108NBA ATP-dependent carboxylate-amine ligase (By similarity) ATC04_04625 ENOG4105F9E Shikimate 5-dehydrogenase ATC04_04635 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ATC04_04640 ENOG4105C26 Dehydrogenase ATC04_04675 ENOG4108KQ5 Integrase catalytic subunit ATC04_04680 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ATC04_04685 ENOG4105EW9 transcriptional regulator AsnC family ATC04_04700 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ATC04_04705 ENOG4105F38 ABC transporter, permease ATC04_04720 ENOG4105KDC 50s ribosomal protein l28 ATC04_04725 ENOG4105W0E 50S ribosomal protein L33 ATC04_04730 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) ATC04_04740 ENOG4105CHR reductase ATC04_04745 ENOG4108426 dNA-binding protein ATC04_04750 ENOG4108426 dNA-binding protein ATC04_04765 ENOG41080T7 secreted protein ATC04_04790 ENOG4107Y80 Major Facilitator superfamily ATC04_04800 ENOG4105D7A ATP-binding protein ATC04_04805 ENOG4105CDA abc transporter atp-binding protein ATC04_04810 ENOG4105DRP amino acid AbC transporter ATC04_04815 ENOG4105EAB amino acid AbC transporter ATC04_04835 ENOG4107GFK fumarate ATC04_04850 ENOG4105DHP deoxycytidine triphosphate deaminase ATC04_04860 ENOG4105D65 subunit l ATC04_04865 ENOG4105MKQ Monovalent cation H antiporter subunit C ATC04_04870 ENOG4108JPZ Monovalent cation H antiporter subunit D ATC04_04875 ENOG4105SC1 monovalent cation H antiporter subunit E ATC04_04885 ENOG4105KJM monovalent cation h antiporter subunit g ATC04_04895 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein ATC04_04900 ENOG4108JJB ABC transporter ATC04_04910 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) ATC04_04960 ENOG4105CFG Acts as a chaperone (By similarity) ATC04_04965 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ ATC04_04970 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ATC04_04975 ENOG4105KNI merR family transcriptional Regulator ATC04_04985 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) ATC04_04990 ENOG410901E Membrane ATC04_05005 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ATC04_05020 ENOG4105WH1 Two component transcriptional regulator luxr family ATC04_05025 ENOG410836F Transposase ATC04_05030 ENOG410836F Transposase ATC04_05040 ENOG4105CXB phosphoribosylaminoimidazole synthetase ATC04_05065 ENOG4105C12 Phosphoribosylglycinamide synthetase ATC04_05070 ENOG4105C8V SAICAR synthetase ATC04_05075 ENOG4105BZ1 (ABC) transporter ATC04_05080 ENOG4105BZ1 (ABC) transporter ATC04_05090 ENOG4105BZ4 penicillin-binding protein ATC04_05095 ENOG4105KME endoribonuclease L-psp ATC04_05110 ENOG4105C0H protease ATC04_05115 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) ATC04_05125 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ATC04_05135 ENOG4105P8F nudix hydrolase ATC04_05180 ENOG4108I5C dEAD DEAH box helicase ATC04_05190 ENOG4105C72 UPF0176 protein ATC04_05210 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ATC04_05215 ENOG4107R33 ppx gppa phosphatase ATC04_05220 ENOG4105EY0 Xylose isomerase domain protein TIM barrel ATC04_05225 ENOG4105II7 pyrroline-5-carboxylate reductase ATC04_05230 ENOG41061H0 Monooxygenase ATC04_05245 ENOG4105DGU Histone deacetylase ATC04_05250 ENOG4105MHT Transcriptional regulator, ARSR family ATC04_05255 ENOG4105D82 Glutamate dehydrogenase ATC04_05265 ENOG4108RXW HAD-superfamily subfamily IB hydrolase ATC04_05275 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) ATC04_05285 ENOG4108RH7 phosphoglycerate mutase ATC04_05290 ENOG4105K63 Thioredoxin ATC04_05295 ENOG4107QIV Cytochrome c biogenesis protein ATC04_05305 ENOG4105CRE cytochrome C ATC04_05330 ENOG4107SIQ Naphthoate synthase ATC04_05335 ENOG4105CSH Transporter ATC04_05340 ENOG4105CHU acetyl-coa acetyltransferase ATC04_05345 ENOG4105E39 Enoyl-CoA hydratase ATC04_05350 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ATC04_05360 ENOG4106HK8 GPR1 FUN34 yaaH family protein ATC04_05390 ENOG4105KA0 thioesterase Superfamily protein ATC04_05395 ENOG4105DXM phenylacetic acid degradation protein ATC04_05415 ENOG4108ZJI phenylacetic acid degradation protein ATC04_05420 ENOG4105RHY Pfam:UPF0157 ATC04_05430 ENOG4105E5Q amino acid AbC transporter ATC04_05435 ENOG4105CDA abc transporter atp-binding protein ATC04_05440 ENOG4105NQG DoxX ATC04_05445 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit ATC04_05450 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit ATC04_05455 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit ATC04_05460 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit ATC04_05465 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ATC04_05470 ENOG4108UKI Enoyl-CoA hydratase ATC04_05475 ENOG4108ZRZ Transcriptional regulator (AsnC family) ATC04_05485 ENOG4105CPP Dehydrogenase, E1 component ATC04_05490 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 ATC04_05505 ENOG4107TCW O-succinylbenzoate synthase ATC04_05515 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) ATC04_05520 ENOG4105CDA abc transporter atp-binding protein ATC04_05525 ENOG4105EAD ABC transporter ATC04_05535 ENOG4105E4F Isochorismate synthase ATC04_05560 ENOG4105C8J )-transporter ATC04_05575 ENOG4105D0M Protease HtpX homolog ATC04_05580 ENOG4108VPT UPF0234 protein ATC04_05590 ENOG41080RH Thioredoxin ATC04_05705 ENOG4105YQ0 ATC04_05710 ENOG4105CDU Replicative dna helicase ATC04_05810 ENOG4105DR5 peptidase ATC04_05835 ENOG4107F2M hemolysin-type calcium-binding region ATC04_05900 ENOG410900P UPF0336 protein ATC04_05910 ENOG4106UW1 Major Facilitator superfamily ATC04_05915 ENOG4107R4N Cell wall formation (By similarity) ATC04_05920 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ATC04_05935 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) ATC04_05950 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) ATC04_05955 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) ATC04_05960 ENOG4107NHD transcriptional regulator ATC04_05970 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands ATC04_06020 ENOG410683Z Preprotein translocase SecE subunit ATC04_06025 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) ATC04_06030 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) ATC04_06035 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) ATC04_06040 ENOG4108VZM 50s ribosomal protein L10 ATC04_06045 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) ATC04_06060 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ATC04_06065 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ATC04_06075 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) ATC04_06080 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) ATC04_06085 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ATC04_06090 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ATC04_06100 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) ATC04_06105 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) ATC04_06110 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) ATC04_06115 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) ATC04_06120 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity ATC04_06125 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) ATC04_06130 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) ATC04_06135 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) ATC04_06140 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) ATC04_06150 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal ATC04_06175 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) ATC04_06180 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) ATC04_06185 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits ATC04_06190 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) ATC04_06195 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) ATC04_06200 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) ATC04_06205 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) ATC04_06210 ENOG410849U 50S ribosomal protein L30 ATC04_06220 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) ATC04_06225 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) ATC04_06235 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) ATC04_06240 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits ATC04_06245 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) ATC04_06250 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ATC04_06255 ENOG4108ZT0 50S ribosomal protein l17 ATC04_06265 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) ATC04_06270 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) ATC04_06275 ENOG4108UJD 30S ribosomal protein S9 ATC04_06280 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) ATC04_06285 ENOG4105C6Y Udp-glucose 6-dehydrogenase ATC04_06310 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) ATC04_06315 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) ATC04_06320 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ATC04_06325 ENOG4105CS9 pantothenic acid kinase ATC04_06330 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) ATC04_06335 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ATC04_06340 ENOG4108097 ATP-binding protein ATC04_06350 ENOG41080E2 ribosomal-protein-alanine acetyltransferase ATC04_06355 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ATC04_06360 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) ATC04_06375 ENOG4108IQI permease ATC04_06380 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) ATC04_06385 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ATC04_06405 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ATC04_06430 ENOG4107QVP Dehydrogenase ATC04_06445 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ATC04_06465 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase ATC04_06470 ENOG4108Z9I -acetyltransferase ATC04_06505 ENOG4105CSR polyphosphate kinase 2 ATC04_06515 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ATC04_06520 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ATC04_06525 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) ATC04_06530 ENOG4105C3G gtp-binding protein ATC04_06580 ENOG4105CKK Glycosyl transferase, family 2 ATC04_06595 ENOG4105EI2 Pseudouridine synthase ATC04_06600 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ ATC04_06605 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands ATC04_06640 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) ATC04_06710 ENOG4105CHR reductase ATC04_06715 ENOG4108MXF Alpha Beta Hydrolase ATC04_06745 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) ATC04_06760 ENOG4105CI3 gtp-binding protein typa ATC04_06785 ENOG4108Z4U Ferredoxin ATC04_06805 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) ATC04_06810 ENOG4107R4C succinyl-diaminopimelate desuccinylase ATC04_06815 ENOG4105DRP amino acid AbC transporter ATC04_06820 ENOG4108Q1T ABC transporter ATC04_06825 ENOG4107UBR Extracellular solute-binding protein family 3 ATC04_06830 ENOG4105CDA abc transporter atp-binding protein ATC04_06835 ENOG4108URH decarboxylase ATC04_06845 ENOG4107ZBN O-methyltransferase ATC04_06850 ENOG4105DU6 RNA polymerase ATC04_06855 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) ATC04_06860 ENOG4105D1F ATP-binding protein ATC04_06870 ENOG4105CJW magnesium transporter ATC04_06880 ENOG4107T6F Xaa-Pro aminopeptidase ATC04_06890 ENOG4105CEC DNA methylase N-4 N-6 ATC04_06900 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) ATC04_06910 ENOG4108R86 Transcriptional regulator ATC04_06915 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) ATC04_06920 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) ATC04_06925 ENOG4105C1Q protoporphyrinogen oxidase ATC04_06930 ENOG4107JTW chlorite dismutase ATC04_06935 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) ATC04_06950 ENOG4105D52 delta-aminolevulinic acid dehydratase ATC04_06955 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase ATC04_06960 ENOG4105CUB amino acid ATC04_06965 ENOG4105D01 (LipO)protein ATC04_06970 ENOG4108UMI ABC transporter, permease ATC04_06975 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ATC04_07025 ENOG41063PX domain protein ATC04_07030 ENOG4105DJZ UPF0182 protein ATC04_07050 ENOG4105D5G Transposase ATC04_07060 ENOG41087YS Phage shock protein A ATC04_07070 ENOG4105C0H protease ATC04_07080 ENOG4105C10 Electron transfer flavoprotein ATC04_07095 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) ATC04_07115 ENOG4105EEI dihydropteroate synthase ATC04_07130 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) ATC04_07150 ENOG4105CEI nitrite reductase ATC04_07160 ENOG4108M8W Monooxygenase ATC04_07175 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) ATC04_07180 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ATC04_07185 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ATC04_07190 ENOG4108JQ6 ABC transporter ATC04_07205 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ATC04_07210 ENOG4105BZU Histidine kinase ATC04_07215 ENOG4108T3R lipoprotein lpqB ATC04_07220 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) ATC04_07225 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea ATC04_07230 ENOG4105T0Z Conserved Protein ATC04_07235 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving ATC04_07265 ENOG4105C7I Dehydrogenase ATC04_07275 ENOG41068JE domain protein ATC04_07290 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ATC04_07300 ENOG4108V6E Cell division protein mraZ ATC04_07305 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) ATC04_07315 ENOG4105CJN penicillin-binding protein ATC04_07330 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) ATC04_07335 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) ATC04_07340 ENOG4105CNI cell division protein FtsW ATC04_07345 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) ATC04_07350 ENOG4105DFU Cell wall formation (By similarity) ATC04_07355 ENOG4108UFP Essential cell division protein (By similarity) ATC04_07360 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) ATC04_07365 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase ATC04_07370 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) ATC04_07385 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) ATC04_07395 ENOG4105C0B DNA polymerase III (alpha subunit) ATC04_07400 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) ATC04_07405 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) ATC04_07420 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) ATC04_07425 ENOG4105C5F glutamine synthetase ATC04_07430 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) ATC04_07440 ENOG4107Y2X deaminase ATC04_07450 ENOG4105C5F glutamine synthetase ATC04_07465 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) ATC04_07470 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) ATC04_07475 ENOG4105D9P serine threonine protein kinase ATC04_07495 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ATC04_07515 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ATC04_07520 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ATC04_07535 ENOG4105C4M (Ubiquinol oxidase) subunit I ATC04_07540 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ATC04_07545 ENOG4108JJ9 ABC, transporter ATC04_07550 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ATC04_07555 ENOG410870F Cyclic nucleotide-binding protein ATC04_07585 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) ATC04_07610 ENOG4107VEG TrkA-N domain protein ATC04_07615 ENOG4105C0X amino acid ATC04_07620 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ATC04_07625 ENOG4107QM5 aconitate hydratase ATC04_07670 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) ATC04_07675 ENOG4105EVI UPF0374 protein ATC04_07700 ENOG4105CDH Citrulline--aspartate ligase ATC04_07705 ENOG4105CPC Aldo Keto reductase ATC04_07720 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ATC04_07725 ENOG4105CHU acetyl-coa acetyltransferase ATC04_07755 ENOG4105E0X reductase ATC04_07765 ENOG4108Z66 YbaK ebsC protein ATC04_07785 ENOG4105DKK Benzoate ATC04_07835 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ATC04_07840 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) ATC04_07850 ENOG4105DJV ribulose-phosphate 3-epimerase ATC04_07870 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) ATC04_07875 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) ATC04_07880 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase ATC04_07885 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) ATC04_07890 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) ATC04_07900 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase ATC04_07920 ENOG4105DK0 Indole-3-glycerol phosphate synthase ATC04_07925 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) ATC04_07930 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) ATC04_07935 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) ATC04_07940 ENOG4105CBC glutamate synthase ATC04_07950 ENOG4105CA9 Pyruvate kinase ATC04_07980 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) ATC04_07990 ENOG4105HHS UPF0256 protein ATC04_08000 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) ATC04_08025 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein ATC04_08035 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) ATC04_08060 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) ATC04_08070 ENOG4108V8F Transcriptional regulator, MarR family ATC04_08125 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) ATC04_08145 ENOG4105E18 UPF0276 protein ATC04_08165 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ATC04_08170 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ATC04_08180 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) ATC04_08185 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) ATC04_08190 ENOG4105CHW UPF0052 protein ATC04_08195 ENOG4105CIE May be required for sporulation (By similarity) ATC04_08210 ENOG4105BZA Phosphoglycerate kinase ATC04_08215 ENOG4105CP7 Triose-phosphate isomerase ATC04_08230 ENOG41080HI glycine oxidase ATC04_08255 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) ATC04_08265 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) ATC04_08290 ENOG4105CJ1 ABC, transporter ATC04_08310 ENOG4105C3K feS assembly ATPase SufC ATC04_08315 ENOG4105VG1 fes assembly suf system protein ATC04_08320 ENOG4105VG1 fes assembly suf system protein ATC04_08325 ENOG4105CHU acetyl-coa acetyltransferase ATC04_08330 ENOG4105CEY Amp-dependent synthetase and ligase ATC04_08335 ENOG4107ZYJ bioY protein ATC04_08340 ENOG4107QCX Transporter ATC04_08345 ENOG4108JJB ABC transporter ATC04_08350 ENOG4105N14 lysine exporter protein LysE YggA ATC04_08355 ENOG4108XM1 transcriptional regulator AsnC family ATC04_08360 ENOG4106UW1 Major Facilitator superfamily ATC04_08395 ENOG4108Z4X TRANSCRIPTIONal ATC04_08400 ENOG4105C29 acyl-CoA thioesterase ATC04_08425 ENOG4108YZG isomerase ATC04_08450 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation ATC04_08455 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ATC04_08460 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ATC04_08465 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) ATC04_08470 ENOG4105MC2 DSBA oxidoreductase ATC04_08480 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) ATC04_08505 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) ATC04_08510 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) ATC04_08540 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ATC04_08550 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) ATC04_08565 ENOG4105EYF MMPL domain protein ATC04_08570 ENOG4105WH1 Two component transcriptional regulator luxr family ATC04_08575 ENOG4105ENE Histidine kinase ATC04_08590 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) ATC04_08595 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase ATC04_08605 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) ATC04_08640 ENOG4105C03 ribonuclease ATC04_08645 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) ATC04_08650 ENOG4105K46 50S ribosomal protein l27 ATC04_08655 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control ATC04_08660 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) ATC04_08665 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) ATC04_08675 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) ATC04_08685 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) ATC04_08745 ENOG4105C85 amino acid ATC04_08750 ENOG4105CIH Imidazole acetol-phosphate transaminase ATC04_08760 ENOG4107EXU Short-chain dehydrogenase reductase Sdr ATC04_08775 ENOG4105DND Transcriptional regulator ATC04_08780 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) ATC04_08785 ENOG4105IW1 AmiS UreI transporter ATC04_08790 ENOG4105C5H ABC transporter ATC04_08810 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ATC04_08835 ENOG4105DFA alanine racemase domain protein ATC04_08840 ENOG4105C7K acetolactate synthase ATC04_08845 ENOG4105DFA alanine racemase domain protein ATC04_08855 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) ATC04_08860 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ATC04_08865 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ATC04_08880 ENOG4108HH4 Major Facilitator Superfamily ATC04_08920 ENOG4108RAV Conserved protein ATC04_08930 ENOG4105C5X domain protein ATC04_08945 ENOG4105CSH Transporter ATC04_08965 ENOG4105C0B DNA polymerase III (alpha subunit) ATC04_08995 ENOG4105C22 threonyL-tRNA synthetase ATC04_09005 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) ATC04_09010 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ATC04_09015 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ATC04_09035 ENOG4105CIG ABC transporter ATC04_09045 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 ATC04_09050 ENOG4105N2W Transcriptional regulator ATC04_09060 ENOG4105DRS transport system, permease ATC04_09070 ENOG4108QXE glycerophosphoryl diester phosphodiesterase ATC04_09075 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) ATC04_09090 ENOG4108U7W acetyltransferase ATC04_09095 ENOG4105DGW oligopeptidase A ATC04_09105 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) ATC04_09110 ENOG4105CDY transcriptional regulatory protein ATC04_09115 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) ATC04_09120 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) ATC04_09125 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) ATC04_09130 ENOG4105VIE preprotein translocase, subunit YajC ATC04_09140 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ATC04_09145 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ATC04_09155 ENOG4105C99 atpase involved in dna repair ATC04_09160 ENOG4105CUT histidyl-tRNA synthetase ATC04_09165 ENOG4105C9M aspartyl-trna synthetase ATC04_09180 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) ATC04_09190 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) ATC04_09205 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) ATC04_09210 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) ATC04_09220 ENOG4105E2X shikimate dehydrogenase ATC04_09225 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase ATC04_09230 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) ATC04_09235 ENOG4105D49 3-dehydroquinate synthase ATC04_09245 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) ATC04_09250 ENOG410803B Involved in the transcription termination process (By similarity) ATC04_09255 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) ATC04_09260 ENOG4105CXT aspartate transcarbamylase ATC04_09265 ENOG4105CD3 dihydroorotase ATC04_09275 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain ATC04_09280 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain ATC04_09285 ENOG4105SKN orotidine 5''-phosphate decarboxylase ATC04_09295 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) ATC04_09300 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) ATC04_09310 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP ATC04_09335 ENOG4105DKT Transcriptional regulator ATC04_09345 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ATC04_09350 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ATC04_09365 ENOG4105C8T Leucyl-tRNA synthetase ATC04_09370 ENOG4105EPR degv family ATC04_09380 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 ATC04_09390 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) ATC04_09400 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) ATC04_09420 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) ATC04_09425 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ATC04_09430 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) ATC04_09445 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) ATC04_09455 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) ATC04_09465 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ATC04_09470 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) ATC04_09475 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) ATC04_09480 ENOG4105E5G Alpha beta hydrolase fold ATC04_09485 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) ATC04_09505 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) ATC04_09510 ENOG4105BZ9 Cytochrome C oxidase, subunit I ATC04_09515 ENOG4108ZRS Part of cytochrome c oxidase, its function is ATC04_09520 ENOG4105FDP GntR family transcriptional regulator ATC04_09530 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) ATC04_09535 ENOG4107EUI c reductase, iron-sulfur ATC04_09540 ENOG4107UDY cytochrome C ATC04_09545 ENOG4105CCU oxidase (Subunit III) ATC04_09550 ENOG4108I0Q anthranilate phosphoribosyltransferase ATC04_09580 ENOG4105NAE bifunctional deaminase-reductase domain protein ATC04_09600 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ATC04_09625 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) ATC04_09640 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) ATC04_09665 ENOG4108V1T peptidylprolyl cis-trans isomerase ATC04_09670 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) ATC04_09680 ENOG4105E5F proteasome ATC04_09685 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) ATC04_09700 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 ATC04_09710 ENOG4105C8N cysteinyl-tRNA synthetase ATC04_09715 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) ATC04_09735 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ATC04_09745 ENOG41062D9 Histidine kinase ATC04_09750 ENOG4108KXV response regulator ATC04_09755 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) ATC04_09765 ENOG4107EFR Flavocytochrome c ATC04_09780 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ATC04_09790 ENOG4105CHR reductase ATC04_09855 ENOG4107R3N Filamentation induced by cAMP protein fic ATC04_09860 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) ATC04_09865 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family ATC04_09870 ENOG4105NRA 50s ribosomal protein l31 type b ATC04_09940 ENOG4105DKW ABC transporter ATC04_09970 ENOG4105H9W Short-chain dehydrogenase reductase Sdr ATC04_09975 ENOG4105CHR reductase ATC04_10000 ENOG4105C5H ABC transporter ATC04_10035 ENOG41090CE integral membrane protein ATC04_10040 ENOG41090CE integral membrane protein ATC04_10050 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) ATC04_10065 ENOG4105VZ8 Transcriptional regulator ATC04_10070 ENOG4108JA1 polyketide synthase ATC04_10085 ENOG4105C1G acyl-Coa dehydrogenase ATC04_10090 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ATC04_10130 ENOG4107XFJ UPF0246 protein ATC04_10140 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase ATC04_10145 ENOG4105EGD dinuclear metal center protein, YbgI family ATC04_10150 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) ATC04_10155 ENOG4105C6T cysteine synthase ATC04_10160 ENOG4105D7W serine acetyltransferase ATC04_10170 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ATC04_10190 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ATC04_10195 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein ATC04_10215 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) ATC04_10225 ENOG4105C6Z Gluconate ATC04_10230 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family ATC04_10235 ENOG4105Y3U Transglycosylase-associated protein ATC04_10245 ENOG4108UT2 hemolysin iii ATC04_10250 ENOG41067RQ csbd family ATC04_10280 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) ATC04_10295 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) ATC04_10300 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ATC04_10320 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ATC04_10330 ENOG4105C0P Mg chelatase subunit ChlI ATC04_10335 ENOG41080R2 UPF0102 protein ATC04_10345 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ATC04_10350 ENOG4107QYR Signal peptidase i ATC04_10365 ENOG4107QYR Signal peptidase i ATC04_10370 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) ATC04_10375 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) ATC04_10380 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) ATC04_10385 ENOG41082KU UPF0109 protein ATC04_10390 ENOG4105K5M 30s ribosomal protein S16 ATC04_10395 ENOG4105N14 lysine exporter protein LysE YggA ATC04_10420 ENOG410650H (LipO)protein ATC04_10425 ENOG4105DBE peroxidase ATC04_10430 ENOG4105CHU acetyl-coa acetyltransferase ATC04_10435 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) ATC04_10445 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase ATC04_10450 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ATC04_10455 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ATC04_10475 ENOG4105E4C Lytic transglycosylase catalytic ATC04_10495 ENOG4108VX5 3-methyladenine DNA glycosylase ATC04_10505 ENOG4105EXC Acyl-transferase ATC04_10510 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ATC04_10535 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) ATC04_10545 ENOG41062IY 50S ribosomal protein L32 ATC04_10565 ENOG4105F5W AtP-binding protein ATC04_10580 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase ATC04_10585 ENOG4105C39 capsular polysaccharide phosphotransferase ATC04_10600 ENOG4105EY8 ABC transporter ATC04_10610 ENOG4108KGH TRANSCRIPTIONal ATC04_10615 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ATC04_10620 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) ATC04_10635 ENOG4106H78 methyltransferase ATC04_10645 ENOG4105DP4 dak2 domain fusion protein ylov ATC04_10650 ENOG4108KGH TRANSCRIPTIONal ATC04_10660 ENOG4105CPF Cell wall formation (By similarity) ATC04_10665 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase ATC04_10675 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) ATC04_10680 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ATC04_10685 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ATC04_10695 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) ATC04_10705 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) ATC04_10725 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ATC04_10730 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) ATC04_10735 ENOG4105ERH Fumarylacetoacetate hydrolase ATC04_10740 ENOG4105CMR udp-glucose 4-epimerase ATC04_10745 ENOG4105CM2 brancheD-chain amino acid aminotransferase ATC04_10750 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ATC04_10755 ENOG4105BZU Histidine kinase ATC04_10760 ENOG4105WH1 Two component transcriptional regulator luxr family ATC04_10815 ENOG4108KQ5 Integrase catalytic subunit ATC04_10825 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ATC04_10835 ENOG4108QV3 biosynthesis protein ATC04_10840 ENOG4107ZF2 Phosphatase ATC04_10850 ENOG4107Y2G Glycosyl transferase (Group 1 ATC04_10890 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) ATC04_10965 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ATC04_10975 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ATC04_10980 ENOG4105C1B dTDP-glucose 4-6-dehydratase ATC04_10995 ENOG41086KC Transcriptional regulator ATC04_11010 ENOG4105C1B dTDP-glucose 4-6-dehydratase ATC04_11015 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) ATC04_11030 ENOG4105DMQ Methyltransferase ATC04_11035 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase ATC04_11040 ENOG4108ZP8 Acetolactate synthase small subunit ATC04_11045 ENOG4105C7K acetolactate synthase ATC04_11050 ENOG4105C01 Dihydroxy-acid dehydratase ATC04_11060 ENOG410802X bacteriophage n4 adsorption protein b ATC04_11075 ENOG4105BZU Histidine kinase ATC04_11085 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) ATC04_11130 ENOG4105CGD Nad-dependent epimerase dehydratase ATC04_11175 ENOG4105F9U Dehydrogenase ATC04_11185 ENOG4105DWT malate dehydrogenase (quinone) ATC04_11220 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) ATC04_11230 ENOG4105D7B Flagellar biosynthesis protein flha ATC04_11235 ENOG4105D00 flagellar biosynthetic protein flhB ATC04_11245 ENOG4105VS8 Flagellar biosynthetic protein fliq ATC04_11250 ENOG4105CN7 Flagellar biosynthetic protein FliP ATC04_11260 ENOG4105DD5 Flagellar motor switch protein ATC04_11270 ENOG4106VK6 Flagellar motor protein ATC04_11275 ENOG4105E14 MotA TolQ exbB proton channel ATC04_11285 ENOG4105BZE flagellar hook protein, FlgE ATC04_11290 ENOG4105W00 Flagellar hook capping protein ATC04_11300 ENOG4107SN7 NLP P60 protein ATC04_11325 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) ATC04_11335 ENOG4108ZC9 flagellar basal-body rod protein flgc ATC04_11340 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) ATC04_11355 ENOG410804A Flagellar hook-associated 2 domain-containing protein ATC04_11360 ENOG4105I03 Flagellin ATC04_11365 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ATC04_11375 ENOG4105E1Q flagellar hook-associated protein ATC04_11380 ENOG4105DTJ flagellar hook-associated protein ATC04_11385 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) ATC04_11395 ENOG4105K56 Transcriptional regulator ATC04_11425 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase ATC04_11435 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) ATC04_11460 ENOG4105C01 Dihydroxy-acid dehydratase ATC04_11480 ENOG4108WYP Transcriptional regulator ATC04_11485 ENOG4105C26 Dehydrogenase ATC04_11540 ENOG4105EG2 ABC transporter, permease ATC04_11545 ENOG4105D56 permease protein ATC04_11555 ENOG4105CG3 alpha amylase, catalytic region ATC04_11560 ENOG4105ETE Transcriptional regulator (LacI family ATC04_11580 ENOG4105EYH Exonuclease ATC04_11585 ENOG4107RH8 nuclease SbcCD subunit D ATC04_11600 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) ATC04_11610 ENOG4105DVE abc transporter atp-binding protein ATC04_11635 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ATC04_11640 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) ATC04_11655 ENOG4105EUJ GTP cyclohydrolase i ATC04_11670 ENOG4108RQ5 Beta-lactamase domain-containing protein ATC04_11675 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) ATC04_11685 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) ATC04_11690 ENOG4107RKP Nicotinate phosphoribosyltransferase ATC04_11695 ENOG4108RWI nicotinamidase ATC04_11710 ENOG4105CRK lysyL-tRNA synthetase ATC04_11760 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) ATC04_11775 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) ATC04_11780 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) ATC04_11785 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) ATC04_11790 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) ATC04_11795 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ATC04_11800 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) ATC04_11805 ENOG4106DE0 ATP synthase ATC04_11810 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) ATC04_11820 ENOG4105ESV Glycosyl transferase, family 4 ATC04_11825 ENOG4107UIY sua5 ycio yrdc ywlc family protein ATC04_11830 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ATC04_11835 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) ATC04_11845 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) ATC04_11850 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) ATC04_11855 ENOG4105D6E homoserine dehydrogenase ATC04_11860 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ATC04_11865 ENOG4105C75 arginyL-tRNA synthetase ATC04_11890 ENOG4105CQ7 ATP-dependent helicase ATC04_11895 ENOG4107ZUX Histidine triad (HIT) protein ATC04_11905 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) ATC04_11930 ENOG4105DIK (ABC) transporter ATC04_11935 ENOG4105C37 (CBS) domain ATC04_11940 ENOG4105C37 (CBS) domain ATC04_11945 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 ATC04_11960 ENOG4105EMN RNA polymerase sigma factor ATC04_11965 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase ATC04_11975 ENOG4107TK4 histidinol-phosphate phosphatase ATC04_11980 ENOG4107RPQ ABC transporter ATC04_11985 ENOG4108U51 Universal stress protein ATC04_11990 ENOG4107JBM CrcB-like protein ATC04_11995 ENOG41083TI Protein CrcB homolog ATC04_12005 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) ATC04_12010 ENOG4105E4C Lytic transglycosylase catalytic ATC04_12015 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) ATC04_12020 ENOG4105CAK Cell division ATP-binding protein ftsE ATC04_12025 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) ATC04_12125 ENOG4108C33 Resolvase ATC04_12145 ENOG4105VTR Integrase ATC04_12160 ENOG4105EC2 ftsk spoIIIe ATC04_12175 ENOG4105D9P serine threonine protein kinase ATC04_12180 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase ATC04_12200 ENOG4108IQE Amp-dependent synthetase and ligase ATC04_12210 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) ATC04_12215 ENOG4107SKI cobyrinic Acid a,c-diamide synthase ATC04_12235 ENOG4108UW8 fha domain-containing protein ATC04_12240 ENOG4105K78 MarR family Transcriptional regulator ATC04_12245 ENOG4105QPS Monooxygenase ATC04_12260 ENOG4105JAB phenazine biosynthesis protein, phzf family ATC04_12270 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) ATC04_12275 ENOG4105CAT Cytidine monophosphate kinase ATC04_12290 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) ATC04_12295 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) ATC04_12310 ENOG4107QJT sodium dicarboxylate symporter ATC04_12315 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ATC04_12320 ENOG4108MRH transcriptional regulatory protein ATC04_12330 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ATC04_12345 ENOG4105CR4 methylisocitrate lyase ATC04_12360 ENOG4105VMP Transcriptional regulator ATC04_12370 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ATC04_12375 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ATC04_12380 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) ATC04_12385 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) ATC04_12390 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ATC04_12405 ENOG4105DSU hydrolase ATC04_12435 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ATC04_12445 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) ATC04_12455 ENOG4105CH7 arginosuccinase ATC04_12460 ENOG4108UVJ appr-1-p processing domain protein ATC04_12465 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) ATC04_12470 ENOG4105DBV ornithine carbamoyltransferase ATC04_12475 ENOG4105C8Y Acetylornithine aminotransferase ATC04_12480 ENOG4105CAS nag kinase ATC04_12485 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) ATC04_12490 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase ATC04_12495 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein ATC04_12525 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) ATC04_12535 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) ATC04_12540 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) ATC04_12545 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) ATC04_12555 ENOG4105M6F mutator MutT protein ATC04_12560 ENOG4108RWN rrna methyltransferase ATC04_12565 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) ATC04_12575 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) ATC04_12595 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase ATC04_12600 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) ATC04_12605 ENOG4105ECC imidazole-glycerol-phosphate dehydratase ATC04_12610 ENOG4105CIH Imidazole acetol-phosphate transaminase ATC04_12620 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) ATC04_12630 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ATC04_12635 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) ATC04_12640 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) ATC04_12645 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) ATC04_12650 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) ATC04_12660 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) ATC04_12675 ENOG4105CEV competence damage-inducible protein ATC04_12685 ENOG4107QZI cell division protein FtsK ATC04_12700 ENOG4105E90 ABC transporter ATC04_12705 ENOG4108IJ8 ABC transporter ATC04_12710 ENOG4105YB8 TM2 domain containing protein ATC04_12730 ENOG4105CN5 Metallo-Beta-Lactamase ATC04_12735 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ATC04_12750 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) ATC04_12765 ENOG4105C1V Peptidase, M16 ATC04_12780 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein ATC04_12785 ENOG4105CPQ Dehydrogenase ATC04_12795 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein ATC04_12810 ENOG4107S9B Shikimate dehydrogenase ATC04_12815 ENOG4105CSH Transporter ATC04_12820 ENOG4107RSM transcriptional regulator ATC04_12825 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein ATC04_12830 ENOG4107S1Q Phosphatase ATC04_12845 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) ATC04_12870 ENOG4105EXU Membrane ATC04_12885 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) ATC04_12895 ENOG4105DJ2 Major Facilitator Superfamily ATC04_12900 ENOG4107QF7 multi-drug ATC04_12905 ENOG4107HP6 Transcriptional regulator ATC04_12910 ENOG4105E3J oxidoreductase ATC04_12915 ENOG4105Q56 cytochrome P450 ATC04_12945 ENOG4108MRH transcriptional regulatory protein ATC04_12970 ENOG4105SHT UspA domain-containing protein ATC04_12980 ENOG4105E2T synthase III ATC04_12985 ENOG410680H amp-dependent synthetase and ligase ATC04_12990 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase ATC04_13025 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) ATC04_13030 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) ATC04_13035 ENOG4105DTN riboflavin biosynthesis protein ribF ATC04_13050 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) ATC04_13065 ENOG4105CWC Acetylornithine deacetylase ATC04_13070 ENOG4105CSH Transporter ATC04_13075 ENOG4105CK7 Sodium proline symporter ATC04_13095 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) ATC04_13100 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) ATC04_13105 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) ATC04_13115 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) ATC04_13130 ENOG4107S2Z UPF0761 membrane protein ATC04_13140 ENOG4105BZU Histidine kinase ATC04_13145 ENOG4105WH1 Two component transcriptional regulator luxr family ATC04_13155 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) ATC04_13185 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) ATC04_13205 ENOG4105DZP Membrane-associated zinc metalloprotease ATC04_13210 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) ATC04_13215 ENOG4105C1G acyl-Coa dehydrogenase ATC04_13235 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ATC04_13255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ATC04_13260 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ATC04_13265 ENOG4105DEF Extracellular solute-binding protein, family 5 ATC04_13270 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 ATC04_13275 ENOG4105CPP Dehydrogenase, E1 component ATC04_13290 ENOG4105CND Glycosyl transferase, family 2 ATC04_13295 ENOG4105CPF Cell wall formation (By similarity) ATC04_13300 ENOG4107W19 lmbE family ATC04_13305 ENOG4107QN1 sodium solute ATC04_13315 ENOG4108HRK Histidine kinase ATC04_13320 ENOG4105DY9 regulatoR ATC04_13340 ENOG4105KNE Phosphatidate cytidylyltransferase ATC04_13345 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) ATC04_13350 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) ATC04_13355 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) ATC04_13360 ENOG4105CE9 30S ribosomal protein S2 ATC04_13375 ENOG4107TYR Glycosyl Transferase ATC04_13395 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ATC04_13410 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) ATC04_13415 ENOG4105DUU IucA IucC family protein ATC04_13460 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) ATC04_13465 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein ATC04_13510 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) ATC04_13515 ENOG4105WQ3 Rna-binding protein ATC04_13530 ENOG41090WU lipolytic protein G-D-S-L family ATC04_13535 ENOG4105DWV Homoserine O-trans-acetylase ATC04_13540 ENOG4108IQK o-acetylhomoserine ATC04_13570 ENOG4105E98 transcriptional regulator DeoR family ATC04_13600 ENOG4105DE4 1-phosphofructokinase ATC04_13615 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) ATC04_13620 ENOG4105CI2 imidazolone-5-propionate hydrolase ATC04_13625 ENOG4105CI2 imidazolone-5-propionate hydrolase ATC04_13635 ENOG4105DWD nucleoside recognition domain protein ATC04_13640 ENOG4105CGP Urocanate hydratase ATC04_13655 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component ATC04_13660 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component ATC04_13665 ENOG4105EPJ extracellular solute-binding protein family 1 ATC04_13675 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ATC04_13680 ENOG4105CPQ Dehydrogenase ATC04_13690 ENOG4105EV4 Multidrug resistance protein mdtH ATC04_13700 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 ATC04_13710 ENOG4108JQ7 (ABC) transporter ATC04_13715 ENOG4105C3U ABC transporter ATC04_13725 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ATC04_13730 ENOG4105DEF Extracellular solute-binding protein, family 5 ATC04_13750 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) ATC04_13755 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) ATC04_13760 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) ATC04_13790 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) ATC04_13795 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) ATC04_13820 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) ATC04_13850 ENOG4105D8K carboxyl transferase ATC04_13865 ENOG4105C2C drug resistance transporter, Bcr CflA ATC04_13875 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase ATC04_13880 ENOG4105NPE arsR family transcriptional regulator ATC04_13885 ENOG4108ETY sodium dicarboxylate symporter ATC04_13900 ENOG4105EYF MMPL domain protein ATC04_13905 ENOG4107WR6 Maf-like protein ATC04_13920 ENOG4106032 Glutathionylspermidine synthase ATC04_13930 ENOG4108JIK carboxylase ATC04_13955 ENOG4105CSH Transporter ATC04_13970 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain ATC04_13975 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) ATC04_14005 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ATC04_14010 ENOG4108UNV SUF system FeS assembly protein, NifU family ATC04_14020 ENOG4105KDM Diguanylate cyclase with gaf sensor ATC04_14025 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) ATC04_14045 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) ATC04_14055 ENOG4105C5H ABC transporter ATC04_14060 ENOG4105F1N DNA alkylation repair ATC04_14095 ENOG4105CHR reductase ATC04_14110 ENOG4105CJP fad dependent oxidoreductase ATC04_14115 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) ATC04_14120 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) ATC04_14125 ENOG4106839 domain protein ATC04_14130 ENOG4105F8V Hydrolase, tatD family ATC04_14135 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ATC04_14160 ENOG4105FF9 glycosyl transferase, family 39 ATC04_14200 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) ATC04_14220 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) ATC04_14225 ENOG4108KGH TRANSCRIPTIONal ATC04_14230 ENOG4105EIP mannose-6-phosphate isomerase ATC04_14250 ENOG4105C9Q fumarate hydratase class II ATC04_14275 ENOG4105C0R drug resistance transporter emrb qaca subfamily ATC04_14295 ENOG4108IAB Phoh family ATC04_14300 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) ATC04_14305 ENOG4105C7Z Conserved Protein ATC04_14315 ENOG4105T1M mycothiol conjugate amidase mca ATC04_14325 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) ATC04_14330 ENOG4105C7B Threonine dehydratase ATC04_14365 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ATC04_14380 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin ATC04_14400 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) ATC04_14415 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) ATC04_14440 ENOG4105UIB (ABC) transporter ATC04_14445 ENOG4108JQ9 ABC transporter ATC04_14450 ENOG4105DIH basic membrane ATC04_14455 ENOG4107RM1 amidohydrolase ATC04_14460 ENOG4105C94 Transporter ATC04_14485 ENOG4105E33 succinate dehydrogenase ATC04_14495 ENOG4105C31 Tryptophanyl-tRNA synthetase ATC04_14500 ENOG4105CGK Exodeoxyribonuclease III ATC04_14525 ENOG4105WH1 Two component transcriptional regulator luxr family ATC04_14535 ENOG4105DUM transcriptional regulator, lysR family ATC04_14540 ENOG4105CSH Transporter ATC04_14570 ENOG4105C5Q Transcriptional regulator ATC04_14590 ENOG4105CSH Transporter ATC04_14595 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) ATC04_14600 ENOG4105F95 Monooxygenase ATC04_14615 ENOG4108Z0R Transferase ATC04_14620 ENOG41086D8 Transcriptional regulator ATC04_14650 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) ATC04_14675 ENOG4107S2Z UPF0761 membrane protein ATC04_14740 ENOG4105CFC Transporter ATC04_14775 ENOG4107R16 Multicopper oxidase ATC04_14800 ENOG4107QIV Cytochrome c biogenesis protein ATC04_14805 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ATC04_14810 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ATC04_14835 ENOG4108R85 Short chain dehydrogenase ATC04_14845 ENOG4108WYP Transcriptional regulator ATC04_14850 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein ATC04_14860 ENOG4105E9K Isocitrate dehydrogenase ATC04_14880 ENOG4105E7W lamb ycsf family protein ATC04_14885 ENOG4107R7A Allophanate hydrolase subunit 2 ATC04_14890 ENOG4108JIK carboxylase ATC04_14920 ENOG4105CFM UPF0317 protein ATC04_14925 ENOG4105C5A transporter ATC04_14930 ENOG4105C94 Transporter ATC04_14935 ENOG4105DC1 bifunctional purine biosynthesis protein purh ATC04_14945 ENOG41079KZ Major Facilitator Superfamily ATC04_14995 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) ATC04_15005 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F ATC04_15010 ENOG4105MS9 Resuscitation-promoting factor ATC04_15015 ENOG4107U9T Pfam:Ribonuclease_BN ATC04_15060 ENOG4107R34 abc transporter permease protein ATC04_15065 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ATC04_15080 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ATC04_15105 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ATC04_15110 ENOG4105C26 Dehydrogenase ATC04_15115 ENOG4105C1G acyl-Coa dehydrogenase ATC04_15120 ENOG4105G9B Transcriptional regulator ATC04_15140 ENOG4105FS7 Transcriptional regulator ATC04_15145 ENOG4105ECY inositol monophosphatase ATC04_15155 ENOG4105C7K acetolactate synthase ATC04_15210 ENOG4105C0D helicase ATC04_15225 ENOG4105CMV Succinyl-CoA synthetase subunit beta ATC04_15265 ENOG4105DR5 peptidase ATC04_15270 ENOG4107R5H iron (metal) dependent repressor, dtxr family ATC04_15275 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) ATC04_15285 ENOG4105VEQ Cold shock protein ATC04_15295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ATC04_15300 ENOG4105BZU Histidine kinase ATC04_15320 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ATC04_15370 ENOG4105CKW Inner membrane protein yedI ATC04_15395 ENOG4108IJ9 (ABC) transporter ATC04_15435 ENOG4105CQB FAD linked oxidase domain protein ATC04_15455 ENOG4105C2N RNA methyltransferase TrmH family group 3 ATC04_15460 ENOG4105C8N cysteinyl-tRNA synthetase ATC04_15465 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) ATC04_15470 ENOG4108VJ1 Transcriptional regulator (CarD family ATC04_15485 ENOG4105BZU Histidine kinase ATC04_15500 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ATC04_15515 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) ATC04_15520 ENOG4107QMP dna polymerase iii subunits gamma and tau ATC04_15645 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ATC04_15650 ENOG4105CV8 reductase ATC04_15690 ENOG4105D22 carbon starvation protein ATC04_15695 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein ATC04_15725 ENOG4105C9U ATP-dependent DNA helicase RecQ ATC04_15740 ENOG41081JD Transcriptional regulator ATC04_15745 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ATC04_15750 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) ATC04_15760 ENOG4105C2C drug resistance transporter, Bcr CflA ATC04_15765 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) ATC04_15785 ENOG4105ETE Transcriptional regulator (LacI family ATC04_15790 ENOG4105CS2 ec 3.2.1.21 ATC04_15820 ENOG4105ECB domain protein ATC04_15825 ENOG4108IG5 Transcriptional regulator ATC04_15850 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ATC04_15855 ENOG4105BZU Histidine kinase ATC04_15860 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) ATC04_15865 ENOG4108Z6B deaminase ATC04_15890 ENOG4105PTV Nudix Hydrolase ATC04_15905 ENOG4108IUE nitrate reductase beta subunit ATC04_15930 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) ATC04_15955 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ATC04_15970 ENOG4107TMB Transcriptional regulator ATC04_15995 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ATC04_16000 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ATC04_16005 ENOG4107VXM glycerophosphoryl diester phosphodiesterase ATC04_16030 ENOG4107HP6 Transcriptional regulator ATC04_16035 ENOG4107QNJ CoA-transferase subunit B ATC04_16045 ENOG4105CHU acetyl-coa acetyltransferase ATC04_16050 ENOG4105D2S major facilitator superfamily ATC04_16060 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) ATC04_16065 ENOG4105C94 Transporter ATC04_16085 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase ATC04_16095 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase ATC04_16120 ENOG4105DA5 (ABC) transporter ATC04_16135 ENOG4108JQ1 Dehydrogenase ATC04_16140 ENOG4105D6U Sodium Glutamate Symporter ATC04_16145 ENOG41088SP formiminoglutamate hydrolase ATC04_16150 ENOG4107258 Transcriptional regulator ATC04_16155 ENOG410841Q phosphoesterase PA-phosphatase related protein ATC04_16160 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) ATC04_16165 ENOG4107QRT dEAD DEAH box helicase ATC04_16170 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) ATC04_16205 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) ATC04_16240 ENOG4105DWF phosphomethylpyrimidine kinase ATC04_16255 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) ATC04_16285 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) ATC04_16290 ENOG4105BZU Histidine kinase ATC04_16300 ENOG4105WH1 Two component transcriptional regulator luxr family ATC04_16330 ENOG4105CXY transporter ATC04_16370 ENOG4107R9S Malate synthase ATC04_16380 ENOG4107TB6 phosphoglycerate mutase ATC04_16385 ENOG4105C85 amino acid ATC04_16435 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) ATC04_16465 ENOG4105CFH Aspartokinase ATC04_16475 ENOG4108V9W transcriptional regulatory protein ATC04_16480 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ATC04_16485 ENOG4105D4T Citrate transporter ATC04_16510 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) ATC04_16520 ENOG4105K5B UPF0225 protein ATC04_16525 ENOG410839H phosphoribosylformylglycinamidine synthase ATC04_16530 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I ATC04_16535 ENOG4107QIK phosphoribosylformylglycinamidine synthase ATC04_16550 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA ATC04_16560 ENOG4105CPU Monooxygenase ATC04_16605 ENOG4105MSB protein, conserved in bacteria ATC04_16610 ENOG4105K4P CoA-binding domain protein ATC04_16620 ENOG4105FDT acyl-CoA dehydrogenase ATC04_16630 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ATC04_16635 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ATC04_16650 ENOG4105ECR NmrA family ATC04_16670 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) ATC04_16700 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component ATC04_16705 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ATC04_16710 ENOG4105C94 Transporter ATC04_16720 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) ATC04_16725 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ATC04_16735 ENOG4107TB6 phosphoglycerate mutase ATC04_16745 ENOG4105K4P CoA-binding domain protein ATC04_16750 ENOG4108MES Periplasmic binding protein ATC04_16755 ENOG4105DQ5 transport system permease protein ATC04_16760 ENOG4105TVJ transport system, permease ATC04_16770 ENOG4107EDW L-fucose operon activator ATC04_16775 ENOG4105DE4 1-phosphofructokinase ATC04_16780 ENOG4105DM4 PTS System ATC04_16785 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) ATC04_16800 ENOG4108ZJ4 polysaccharide deacetylase ATC04_16820 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ATC04_16825 ENOG4105C7K acetolactate synthase ATC04_16835 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis ATC04_16850 ENOG4108RNG Permease of the drug metabolite transporter ATC04_16860 ENOG4107RSM transcriptional regulator ATC04_16885 ENOG4108YZA Nitrogen regulatory protein pii ATC04_16890 ENOG4105BZU Histidine kinase ATC04_16895 ENOG4108Z86 Glutamine amidotransferase ATC04_16905 ENOG4107104 thymidine kinase ATC04_16915 ENOG4105C85 amino acid ATC04_16935 ENOG4105GR3 Histidine kinase ATC04_16940 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ATC04_16985 ENOG4105EC2 ftsk spoIIIe ATC04_16990 ENOG4108UGD Serine Threonine protein kinase ATC04_17005 ENOG41061JJ Peptidase family M23 ATC04_17010 ENOG4108JEZ rRNA small subunit methyltransferase G ATC04_17025 ENOG4105CJ1 ABC, transporter ATC04_17040 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) ATC04_17050 ENOG4107RMH nh(3)-dependent nad( ) synthetase ATC04_17070 ENOG4105C1G acyl-Coa dehydrogenase ATC04_17085 ENOG4105E39 Enoyl-CoA hydratase ATC04_17135 ENOG4105C7N Xanthine uracil vitamin C permease ATC04_17260 ENOG4105CQB FAD linked oxidase domain protein ATC04_17280 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) ATC04_17295 ENOG41080RH Thioredoxin ATC04_17315 ENOG4108TGP Thioesterase superfamily protein ATC04_17330 ENOG4105CIR epoxide hydrolase ATC04_17345 ENOG4105C26 Dehydrogenase ATC04_17365 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ATC04_17370 ENOG4105C5H ABC transporter ATC04_17420 ENOG4105CJ3 phosphate transporter ATC04_17435 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ATC04_17450 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) ATC04_17460 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) ATC04_17465 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) ATC04_17475 ENOG4105CEN a g-specific adenine glycosylase ATC04_17510 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase ATC04_17750 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase ATC04_17850 ENOG41085GJ domain protein ATC04_17855 ENOG4108V62 Rhodanese domain protein ATC04_17865 ENOG4105XTG Pfam:DUF156 ATC04_17880 ENOG4105EMN RNA polymerase sigma factor ATC04_17895 ENOG4105M03 Domain of unknown function (DUF955) ATC04_17910 ENOG4105KRQ Addiction module toxin, Txe YoeB family ATC04_17915 ENOG41084HI prevent-host-death family ATC04_17935 ENOG4105K6V RNA polymerase ATC04_17955 ENOG4105E4C Lytic transglycosylase catalytic ATC04_18045 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) ATC04_18055 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) ATC04_18110 ENOG4105ECI YeeC-like protein ATC04_18115 ENOG4105F6A helicase ATC04_18120 ENOG4105D85 methylase ATC04_18180 ENOG4105Y3U Transglycosylase-associated protein ATC04_18310 ENOG4105E4C Lytic transglycosylase catalytic ATC04_18375 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family ATC04_18385 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) ATC04_18435 ENOG4107QJE Chromosome Partitioning Protein ATC04_18475 ENOG4108C33 Resolvase ATC04_18550 ENOG4105E4C Lytic transglycosylase catalytic