locus-tag	class	description
ATC04_00110	COG4977	sequence-specific DNA binding
ATC04_00130	COG0542	response to heat
ATC04_00140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ATC04_00145	COG3590	peptidase
ATC04_00175	COG1476	TRANSCRIPTIONal
ATC04_00200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ATC04_00225	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ATC04_00235	COG0302	gtp cyclohydrolase
ATC04_00240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ATC04_00250	COG0037	tRNA processing
ATC04_00260	COG2027	D-alanyl-D-alanine carboxypeptidase
ATC04_00265	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ATC04_00275	COG1322	Protein conserved in bacteria
ATC04_00305	COG0561	phosphatase activity
ATC04_00310	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ATC04_00330	COG0154	amidase activity
ATC04_00335	COG3104	oligopeptide transport
ATC04_00340	COG3655	Transcriptional regulator
ATC04_00355	COG0033	Phosphoglucomutase
ATC04_00360	COG0833	amino acid
ATC04_00365	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_00380	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ATC04_00385	COG0352	thiamine-phosphate diphosphorylase activity
ATC04_00390	COG0351	phosphomethylpyrimidine kinase
ATC04_00390	COG0352	thiamine-phosphate diphosphorylase activity
ATC04_00390	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ATC04_00395	COG2233	PERMEase
ATC04_00400	COG0477	Major facilitator Superfamily
ATC04_00410	COG1053	succinate dehydrogenase
ATC04_00415	COG0477	Major facilitator Superfamily
ATC04_00425	COG1053	succinate dehydrogenase
ATC04_00430	COG1414	Transcriptional regulator
ATC04_00455	COG0561	phosphatase activity
ATC04_00460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ATC04_00470	COG1024	Enoyl-CoA hydratase
ATC04_00485	COG0412	Dienelactone hydrolase
ATC04_00490	COG1957	nucleoside hydrolase
ATC04_00495	COG1609	Transcriptional regulator
ATC04_00520	COG1716	ATPase activity
ATC04_00540	COG0515	serine threonine protein kinase
ATC04_00545	COG2815	serine threonine protein kinase
ATC04_00545	COG0515	serine threonine protein kinase
ATC04_00555	COG3764	Sortase (surface protein transpeptidase)
ATC04_00565	COG2076	Multidrug Resistance protein
ATC04_00570	COG0583	DNA-binding transcription factor activity
ATC04_00585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ATC04_00600	COG0385	Bile acid
ATC04_00620	COG3266	domain, Protein
ATC04_00625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ATC04_00630	COG0187	DNA topoisomerase II activity
ATC04_00635	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
ATC04_00640	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ATC04_00645	COG0592	DNA-directed DNA polymerase activity
ATC04_00650	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ATC04_00660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ATC04_00665	COG0706	membrane insertase activity
ATC04_00675	COG0357	Ribosomal RNA small subunit methyltransferase G
ATC04_00680	COG1192	Involved in chromosome partitioning
ATC04_00685	COG1475	DNA binding
ATC04_00690	COG3118	belongs to the thioredoxin family
ATC04_00695	COG0492	ferredoxin-NADP+ reductase activity
ATC04_00720	COG1260	myo-inositol-1-phosphate synthase
ATC04_00740	COG1442	glycosyl transferase family 8
ATC04_00740	COG1216	Glycosyl transferase, family 2
ATC04_00745	COG2089	acid synthase
ATC04_00780	COG4585	Histidine kinase
ATC04_00785	COG2197	response regulator
ATC04_00795	COG1362	aminopeptidase activity
ATC04_00810	COG0579	oxidoreductase
ATC04_00815	COG2755	lipolytic protein G-D-S-L family
ATC04_00815	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ATC04_00820	COG0360	Binds together with S18 to 16S ribosomal RNA
ATC04_00830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ATC04_00835	COG0359	binds to the 23S rRNA
ATC04_00840	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ATC04_00875	COG2133	pyrroloquinoline quinone binding
ATC04_00885	COG0318	PFAM AMP-dependent synthetase and ligase
ATC04_00920	COG1476	TRANSCRIPTIONal
ATC04_00925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ATC04_00930	COG0305	Participates in initiation and elongation during chromosome replication
ATC04_00940	COG0477	Major facilitator Superfamily
ATC04_00960	COG1846	Transcriptional regulator
ATC04_00975	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_01010	COG2351	hydroxyisourate hydrolase activity
ATC04_01020	COG2233	PERMEase
ATC04_01025	COG1609	Transcriptional regulator
ATC04_01040	COG2160	L-arabinose isomerase activity
ATC04_01045	COG4213	ABC transporter substrate-binding protein
ATC04_01055	COG4214	carbohydrate transport
ATC04_01060	COG2017	converts alpha-aldose to the beta-anomer
ATC04_01070	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ATC04_01095	COG0531	amino acid
ATC04_01100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ATC04_01115	COG4221	oxidoreductase activity
ATC04_01130	COG2814	Major facilitator Superfamily
ATC04_01135	COG1113	amino acid transport
ATC04_01145	COG1940	carbohydrate kinase activity
ATC04_01155	COG2217	Heavy metal translocating P-type atpase
ATC04_01160	COG1132	(ABC) transporter
ATC04_01165	COG1053	succinate dehydrogenase
ATC04_01195	COG3257	ureidoglycine aminohydrolase activity
ATC04_01210	COG0346	lactoylglutathione lyase activity
ATC04_01225	COG2267	carboxylic ester hydrolase activity
ATC04_01230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ATC04_01255	COG1024	Enoyl-CoA hydratase
ATC04_01255	COG1250	3-hydroxyacyl-CoA dehydrogenase
ATC04_01260	COG0318	PFAM AMP-dependent synthetase and ligase
ATC04_01275	COG0798	PFAM Bile acid sodium symporter
ATC04_01290	COG1309	transcriptional regulator
ATC04_01295	COG2267	carboxylic ester hydrolase activity
ATC04_01305	COG0446	pyridine nucleotide-disulphide oxidoreductase
ATC04_01305	COG1902	pentaerythritol trinitrate reductase activity
ATC04_01320	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_01325	COG0477	Major facilitator Superfamily
ATC04_01330	COG0477	Major facilitator Superfamily
ATC04_01335	COG0183	Belongs to the thiolase family
ATC04_01365	COG2814	Major facilitator Superfamily
ATC04_01375	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_01385	COG0559	Belongs to the binding-protein-dependent transport system permease family
ATC04_01390	COG0411	ABC transporter
ATC04_01395	COG0410	ABC transporter
ATC04_01405	COG0183	Belongs to the thiolase family
ATC04_01430	COG1960	acyl-CoA dehydrogenase activity
ATC04_01435	COG1960	acyl-CoA dehydrogenase activity
ATC04_01440	COG1960	acyl-CoA dehydrogenase activity
ATC04_01445	COG1024	Enoyl-CoA hydratase
ATC04_01450	COG1960	acyl-CoA dehydrogenase activity
ATC04_01460	COG0183	Belongs to the thiolase family
ATC04_01480	COG2070	2-Nitropropane dioxygenase
ATC04_01495	COG1024	Enoyl-CoA hydratase
ATC04_01500	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_01515	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ATC04_01545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ATC04_01560	COG1414	Transcriptional regulator
ATC04_01565	COG3012	SEC-C Motif Domain Protein
ATC04_01580	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ATC04_01590	COG2186	Transcriptional regulator
ATC04_01595	COG0747	negative chemotaxis
ATC04_01600	COG0601	transmembrane transport
ATC04_01605	COG0444	Belongs to the ABC transporter superfamily
ATC04_01610	COG4608	Belongs to the ABC transporter superfamily
ATC04_01615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ATC04_01620	COG1940	carbohydrate kinase activity
ATC04_01625	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ATC04_01655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ATC04_01675	COG1063	alcohol dehydrogenase
ATC04_01685	COG1414	Transcriptional regulator
ATC04_01695	COG0477	Major facilitator Superfamily
ATC04_01705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ATC04_01725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ATC04_01775	COG0318	PFAM AMP-dependent synthetase and ligase
ATC04_01790	COG2200	EAL domain
ATC04_01790	COG2199	diguanylate cyclase activity
ATC04_01790	COG2203	Gaf domain
ATC04_01795	COG3706	GGDEF domain
ATC04_01800	COG0659	secondary active sulfate transmembrane transporter activity
ATC04_01815	COG1929	Belongs to the glycerate kinase type-1 family
ATC04_01820	COG2267	carboxylic ester hydrolase activity
ATC04_01870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ATC04_01890	COG0366	Alpha amylase catalytic
ATC04_01895	COG0395	ABC-type sugar transport system, permease component
ATC04_01900	COG1175	transmembrane transport
ATC04_01915	COG0738	Major facilitator superfamily
ATC04_01940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ATC04_01945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ATC04_01965	COG1278	Cold shock
ATC04_01985	COG1953	Uracil, thiamine, allantoin
ATC04_01990	COG3622	Belongs to the hyi family
ATC04_01995	COG2084	Dehydrogenase
ATC04_02000	COG3960	tartronate-semialdehyde synthase activity
ATC04_02005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ATC04_02015	COG1295	ribonuclease BN
ATC04_02035	COG2855	membrane
ATC04_02050	COG2205	protein histidine kinase activity
ATC04_02055	COG0745	RESPONSE REGULATOR receiver
ATC04_02065	COG2755	lipolytic protein G-D-S-L family
ATC04_02065	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ATC04_02105	COG2066	Belongs to the glutaminase family
ATC04_02130	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_02135	COG3848	Pyruvate phosphate dikinase
ATC04_02135	COG0574	Belongs to the PEP-utilizing enzyme family
ATC04_02140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ATC04_02140	COG0574	Belongs to the PEP-utilizing enzyme family
ATC04_02150	COG1414	Transcriptional regulator
ATC04_02170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ATC04_02175	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ATC04_02205	COG1122	ATPase activity
ATC04_02230	COG2801	Transposase and inactivated derivatives
ATC04_02265	COG2963	transposase activity
ATC04_02290	COG2508	Transcriptional regulator
ATC04_02300	COG0477	Major facilitator Superfamily
ATC04_02315	COG0028	Belongs to the TPP enzyme family
ATC04_02320	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_02345	COG0415	Belongs to the DNA photolyase family
ATC04_02360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ATC04_02370	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_02380	COG3285	dna ligase
ATC04_02380	COG1793	dna ligase
ATC04_02385	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ATC04_02400	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_02425	COG1335	isochorismatase
ATC04_02435	COG0531	amino acid
ATC04_02440	COG2323	membrane
ATC04_02450	COG2154	pterin-4-alpha-carbinolamine dehydratase
ATC04_02475	COG0501	Belongs to the peptidase M48B family
ATC04_02505	COG1960	acyl-CoA dehydrogenase activity
ATC04_02510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ATC04_02510	COG0045	succinate-CoA ligase (ADP-forming) activity
ATC04_02510	COG1042	CoA-binding domain protein
ATC04_02515	COG1309	transcriptional regulator
ATC04_02535	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_02540	COG0477	Major facilitator Superfamily
ATC04_02580	COG1960	acyl-CoA dehydrogenase activity
ATC04_02585	COG1960	acyl-CoA dehydrogenase activity
ATC04_02600	COG2030	dehydratase
ATC04_02630	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ATC04_02640	COG0583	DNA-binding transcription factor activity
ATC04_02655	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ATC04_02665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ATC04_02670	COG0601	transmembrane transport
ATC04_02675	COG0747	negative chemotaxis
ATC04_02685	COG1266	CAAX protease self-immunity
ATC04_02690	COG2814	Major facilitator Superfamily
ATC04_02700	COG0534	Mate efflux family protein
ATC04_02710	COG0477	Major facilitator Superfamily
ATC04_02730	COG0531	amino acid
ATC04_02735	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ATC04_02755	COG2154	pterin-4-alpha-carbinolamine dehydratase
ATC04_02760	COG0531	amino acid
ATC04_02765	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ATC04_02775	COG1113	amino acid transport
ATC04_02785	COG1289	transmembrane transporter activity
ATC04_02805	COG1937	Protein conserved in bacteria
ATC04_02835	COG2807	transmembrane transport
ATC04_02880	COG1842	Phage shock protein A
ATC04_02900	COG3850	Histidine kinase
ATC04_02925	COG1607	acyl-coa hydrolase
ATC04_02930	COG2066	Belongs to the glutaminase family
ATC04_02970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ATC04_02975	COG2957	Belongs to the agmatine deiminase family
ATC04_03015	COG2226	methyltransferase
ATC04_03020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ATC04_03025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ATC04_03040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ATC04_03045	COG0436	Aminotransferase
ATC04_03060	COG1228	amidohydrolase
ATC04_03065	COG0006	proline dipeptidase activity
ATC04_03085	COG1131	(ABC) transporter
ATC04_03095	COG4585	Histidine kinase
ATC04_03100	COG2197	response regulator
ATC04_03115	COG0318	PFAM AMP-dependent synthetase and ligase
ATC04_03130	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ATC04_03140	COG2233	PERMEase
ATC04_03160	COG0277	FAD linked oxidase domain protein
ATC04_03170	COG0667	Aldo Keto reductase
ATC04_03180	COG1648	precorrin-2 dehydrogenase activity
ATC04_03180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ATC04_03185	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ATC04_03185	COG2146	nitrite reductase [NAD(P)H] activity
ATC04_03200	COG0243	molybdopterin cofactor binding
ATC04_03205	COG2223	nitrite transmembrane transporter activity
ATC04_03215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ATC04_03235	COG1950	PFAM Membrane protein of
ATC04_03240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ATC04_03250	COG0022	dehydrogenase e1 component
ATC04_03255	COG0508	dehydrogenase complex catalyzes the overall conversion of
ATC04_03260	COG0823	Involved in the tonB-independent uptake of proteins
ATC04_03260	COG1506	peptidase
ATC04_03270	COG1027	Aspartate ammonia-lyase
ATC04_03280	COG2186	Transcriptional regulator
ATC04_03295	COG0028	Belongs to the TPP enzyme family
ATC04_03300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ATC04_03305	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ATC04_03320	COG0183	Belongs to the thiolase family
ATC04_03340	COG1414	Transcriptional regulator
ATC04_03395	COG2814	Major facilitator Superfamily
ATC04_03410	COG0318	PFAM AMP-dependent synthetase and ligase
ATC04_03450	COG1733	regulation of RNA biosynthetic process
ATC04_03460	COG0477	Major facilitator Superfamily
ATC04_03475	COG2149	membrane
ATC04_03480	COG1960	acyl-CoA dehydrogenase activity
ATC04_03495	COG2855	membrane
ATC04_03500	COG0583	DNA-binding transcription factor activity
ATC04_03510	COG0583	DNA-binding transcription factor activity
ATC04_03520	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_03525	COG0477	Major facilitator Superfamily
ATC04_03530	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ATC04_03535	COG1082	Xylose isomerase domain protein TIM barrel
ATC04_03540	COG1414	Transcriptional regulator
ATC04_03545	COG2050	protein possibly involved in aromatic compounds catabolism
ATC04_03555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ATC04_03585	COG1113	amino acid transport
ATC04_03590	COG2301	Belongs to the HpcH HpaI aldolase family
ATC04_03595	COG1115	amino acid carrier protein
ATC04_03600	COG0179	Fumarylacetoacetate (FAA) hydrolase
ATC04_03605	COG1174	glycine betaine transport
ATC04_03615	COG1174	glycine betaine transport
ATC04_03640	COG1556	Lactate utilization protein
ATC04_03645	COG1139	Iron-sulfur cluster binding protein
ATC04_03650	COG0247	lactate metabolic process
ATC04_03655	COG1620	l-lactate permease
ATC04_03660	COG2188	Transcriptional regulator
ATC04_03680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ATC04_03695	COG2146	nitrite reductase [NAD(P)H] activity
ATC04_03705	COG2211	Major facilitator Superfamily
ATC04_03715	COG1522	sequence-specific DNA binding
ATC04_03725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ATC04_03730	COG0569	domain protein
ATC04_03790	COG0789	Transcriptional regulator
ATC04_03820	COG1121	(ABC) transporter
ATC04_03825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ATC04_03830	COG3639	organic phosphonate transmembrane transporter activity
ATC04_03850	COG2188	Transcriptional regulator
ATC04_03855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ATC04_03860	COG1321	iron dependent repressor
ATC04_03865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ATC04_03885	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ATC04_03890	COG2986	histidine ammonia-lyase
ATC04_03905	COG0783	Belongs to the Dps family
ATC04_03915	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_03925	COG4948	Mandelate Racemase Muconate Lactonizing
ATC04_03950	COG1172	Belongs to the binding-protein-dependent transport system permease family
ATC04_03955	COG1879	ABC-type sugar transport system periplasmic component
ATC04_03960	COG2186	Transcriptional regulator
ATC04_03965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ATC04_03970	COG3145	DNA-N1-methyladenine dioxygenase activity
ATC04_03980	COG2814	Major facilitator Superfamily
ATC04_04000	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_04005	COG1063	alcohol dehydrogenase
ATC04_04015	COG1404	Belongs to the peptidase S8 family
ATC04_04030	COG3191	aminopeptidase activity
ATC04_04070	COG0561	phosphatase activity
ATC04_04075	COG1473	amidohydrolase
ATC04_04095	COG1982	Orn Lys Arg decarboxylase major
ATC04_04115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ATC04_04140	COG0789	Transcriptional regulator
ATC04_04160	COG4152	abc transporter atp-binding protein
ATC04_04165	COG2197	response regulator
ATC04_04170	COG4585	Histidine kinase
ATC04_04180	COG0135	phosphoribosylanthranilate isomerase activity
ATC04_04190	COG4988	ABC transporter
ATC04_04195	COG1132	(ABC) transporter
ATC04_04200	COG0069	glutamate synthase activity
ATC04_04210	COG0583	DNA-binding transcription factor activity
ATC04_04235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ATC04_04240	COG1278	Cold shock
ATC04_04245	COG0477	Major facilitator Superfamily
ATC04_04260	COG2860	membrane
ATC04_04270	COG0823	Involved in the tonB-independent uptake of proteins
ATC04_04270	COG1506	peptidase
ATC04_04270	COG4946	Tricorn protease homolog
ATC04_04290	COG1528	Iron-storage protein
ATC04_04300	COG2197	response regulator
ATC04_04325	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_04330	COG0667	Aldo Keto reductase
ATC04_04335	COG2267	carboxylic ester hydrolase activity
ATC04_04340	COG1643	Atp-dependent helicase
ATC04_04345	COG1960	acyl-CoA dehydrogenase activity
ATC04_04350	COG1309	transcriptional regulator
ATC04_04395	COG1136	(ABC) transporter
ATC04_04410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ATC04_04415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ATC04_04420	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ATC04_04425	COG1120	ATPase activity
ATC04_04435	COG1132	(ABC) transporter
ATC04_04450	COG0435	Glutathione S-transferase
ATC04_04465	COG0531	amino acid
ATC04_04480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ATC04_04480	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ATC04_04485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ATC04_04490	COG0509	glycine decarboxylation via glycine cleavage system
ATC04_04495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ATC04_04505	COG2239	Acts as a magnesium transporter
ATC04_04510	COG1902	pentaerythritol trinitrate reductase activity
ATC04_04545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ATC04_04560	COG3226	Transcriptional regulator
ATC04_04590	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ATC04_04610	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ATC04_04625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ATC04_04675	COG2801	Transposase and inactivated derivatives
ATC04_04675	COG3415	Transposase
ATC04_04680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ATC04_04685	COG1522	sequence-specific DNA binding
ATC04_04700	COG3842	ATPase activity
ATC04_04705	COG1176	ABC-type spermidine putrescine transport system, permease component I
ATC04_04720	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ATC04_04725	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ATC04_04730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ATC04_04740	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_04745	COG0776	regulation of translation
ATC04_04750	COG0776	regulation of translation
ATC04_04765	COG2847	Copper chaperone PCu(A)C
ATC04_04790	COG2814	Major facilitator Superfamily
ATC04_04800	COG0433	COG0433 Predicted ATPase
ATC04_04805	COG1126	abc transporter atp-binding protein
ATC04_04810	COG0765	amino acid transport
ATC04_04815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ATC04_04835	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ATC04_04835	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ATC04_04850	COG0717	Belongs to the dCTP deaminase family
ATC04_04860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ATC04_04860	COG2111	Na H antiporter
ATC04_04875	COG1863	multisubunit Na H antiporter MnhE subunit
ATC04_04885	COG1320	monovalent cation:proton antiporter activity
ATC04_04895	COG4721	ABC-type cobalt transport system, permease component
ATC04_04900	COG1122	ATPase activity
ATC04_04910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ATC04_04930	COG1280	lysine exporter protein (LysE YggA)
ATC04_04935	COG1846	Transcriptional regulator
ATC04_04940	COG2409	Drug exporters of the RND superfamily
ATC04_04960	COG0443	Heat shock 70 kDa protein
ATC04_04965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ATC04_04970	COG0484	heat shock protein binding
ATC04_04975	COG0789	Transcriptional regulator
ATC04_04985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ATC04_04990	COG3304	Inner membrane component domain
ATC04_04995	COG0861	Integral membrane protein TerC family
ATC04_05020	COG2197	response regulator
ATC04_05025	COG3547	Transposase (IS116 IS110 IS902 family)
ATC04_05030	COG3547	Transposase (IS116 IS110 IS902 family)
ATC04_05040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ATC04_05065	COG0151	Belongs to the GarS family
ATC04_05070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ATC04_05075	COG1132	(ABC) transporter
ATC04_05080	COG1132	(ABC) transporter
ATC04_05090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ATC04_05095	COG0251	oxidation-reduction process
ATC04_05110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ATC04_05115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ATC04_05125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ATC04_05135	COG0494	nUDIX hydrolase
ATC04_05180	COG1111	helicase
ATC04_05180	COG1205	dead DEAH box helicase
ATC04_05210	COG1754	DNA topoisomerase type I activity
ATC04_05210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ATC04_05215	COG0248	Ppx GppA phosphatase
ATC04_05220	COG1082	Xylose isomerase domain protein TIM barrel
ATC04_05235	COG0569	domain protein
ATC04_05240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ATC04_05245	COG0123	including yeast histone deacetylase and acetoin utilization protein
ATC04_05250	COG0640	Transcriptional regulator
ATC04_05255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ATC04_05265	COG0560	Phosphoserine phosphatase
ATC04_05275	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ATC04_05285	COG0406	alpha-ribazole phosphatase activity
ATC04_05290	COG3118	belongs to the thioredoxin family
ATC04_05295	COG0785	Cytochrome C biogenesis protein
ATC04_05305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ATC04_05330	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ATC04_05335	COG0477	Major facilitator Superfamily
ATC04_05345	COG1024	Enoyl-CoA hydratase
ATC04_05350	COG1250	3-hydroxyacyl-CoA dehydrogenase
ATC04_05360	COG1584	GPR1 FUN34 yaaH family protein
ATC04_05390	COG2050	protein possibly involved in aromatic compounds catabolism
ATC04_05395	COG2030	dehydratase
ATC04_05395	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_05415	COG2050	protein possibly involved in aromatic compounds catabolism
ATC04_05420	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ATC04_05430	COG0765	amino acid transport
ATC04_05435	COG1126	abc transporter atp-binding protein
ATC04_05440	COG2259	Doxx family
ATC04_05445	COG3396	Phenylacetate-CoA oxygenase
ATC04_05450	COG3460	Phenylacetate-CoA oxygenase
ATC04_05455	COG3396	Phenylacetate-CoA oxygenase
ATC04_05460	COG2151	metal-sulfur cluster biosynthetic enzyme
ATC04_05465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ATC04_05470	COG1024	Enoyl-CoA hydratase
ATC04_05475	COG1522	sequence-specific DNA binding
ATC04_05485	COG0022	dehydrogenase e1 component
ATC04_05490	COG0508	dehydrogenase complex catalyzes the overall conversion of
ATC04_05505	COG4948	Mandelate Racemase Muconate Lactonizing
ATC04_05515	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ATC04_05520	COG1126	abc transporter atp-binding protein
ATC04_05525	COG0765	amino acid transport
ATC04_05560	COG0733	neurotransmitter:sodium symporter activity
ATC04_05575	COG0501	Belongs to the peptidase M48B family
ATC04_05580	COG1666	GTP binding
ATC04_05590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ATC04_05705	COG1846	Transcriptional regulator
ATC04_05710	COG0305	Participates in initiation and elongation during chromosome replication
ATC04_05810	COG0739	heme binding
ATC04_05875	COG2357	RelA SpoT domain protein
ATC04_05900	COG2030	dehydratase
ATC04_05910	COG0738	Major facilitator superfamily
ATC04_05915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ATC04_05920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ATC04_05935	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ATC04_05950	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ATC04_05955	COG0456	acetyltransferase
ATC04_05960	COG0745	RESPONSE REGULATOR receiver
ATC04_05970	COG3485	protocatechuate 3,4-dioxygenase
ATC04_06010	COG0436	Aminotransferase
ATC04_06020	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ATC04_06025	COG0250	Participates in transcription elongation, termination and antitermination
ATC04_06030	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ATC04_06035	COG0081	regulation of translation
ATC04_06040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ATC04_06045	COG0222	ribosome binding
ATC04_06050	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ATC04_06060	COG0085	RNA polymerase activity
ATC04_06065	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ATC04_06075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ATC04_06080	COG0049	tRNA binding
ATC04_06085	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ATC04_06090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ATC04_06100	COG0051	transcription antitermination factor activity, RNA binding
ATC04_06105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ATC04_06110	COG0088	Forms part of the polypeptide exit tunnel
ATC04_06115	COG0089	rRNA binding
ATC04_06120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ATC04_06125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ATC04_06130	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ATC04_06135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ATC04_06140	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ATC04_06150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ATC04_06175	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ATC04_06180	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ATC04_06185	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ATC04_06190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ATC04_06195	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ATC04_06200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ATC04_06205	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ATC04_06210	COG1841	ribosomal large subunit assembly
ATC04_06215	COG0200	Binds to the 23S rRNA
ATC04_06225	COG0563	adenylate kinase activity
ATC04_06235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ATC04_06240	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ATC04_06245	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ATC04_06250	COG0202	RNA polymerase activity
ATC04_06255	COG0203	ribosomal protein L17
ATC04_06265	COG0101	tRNA pseudouridine synthase activity
ATC04_06270	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ATC04_06275	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ATC04_06280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ATC04_06285	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ATC04_06310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ATC04_06310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ATC04_06315	COG0736	holo-[acyl-carrier-protein] synthase activity
ATC04_06320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ATC04_06325	COG1072	(Pantothenic acid kinase))
ATC04_06330	COG1970	mechanosensitive ion channel activity
ATC04_06335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ATC04_06340	COG0802	atpase or kinase
ATC04_06345	COG0456	acetyltransferase
ATC04_06345	COG1214	PFAM Peptidase M22, glycoprotease
ATC04_06350	COG0456	acetyltransferase
ATC04_06355	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ATC04_06360	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ATC04_06375	COG0833	amino acid
ATC04_06380	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ATC04_06385	COG0459	protein refolding
ATC04_06430	COG0516	GMP reductase activity
ATC04_06445	COG0519	Catalyzes the synthesis of GMP from XMP
ATC04_06445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ATC04_06465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ATC04_06470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ATC04_06480	COG1522	sequence-specific DNA binding
ATC04_06505	COG2326	polyphosphate kinase activity
ATC04_06515	COG1722	exodeoxyribonuclease VII activity
ATC04_06520	COG1570	exodeoxyribonuclease VII activity
ATC04_06525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ATC04_06530	COG0012	GTP binding
ATC04_06580	COG0463	Glycosyl transferase, family 2
ATC04_06605	COG4044	May play a role in the intracellular transport of hydrophobic ligands
ATC04_06665	COG0798	PFAM Bile acid sodium symporter
ATC04_06710	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_06715	COG2267	carboxylic ester hydrolase activity
ATC04_06745	COG2022	thiamine diphosphate biosynthetic process
ATC04_06775	COG1819	glycosyl
ATC04_06805	COG2171	N-acyltransferase activity
ATC04_06810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ATC04_06815	COG0765	amino acid transport
ATC04_06820	COG0765	amino acid transport
ATC04_06825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ATC04_06830	COG1126	abc transporter atp-binding protein
ATC04_06835	COG1611	Belongs to the LOG family
ATC04_06850	COG1595	DNA-templated transcription, initiation
ATC04_06860	COG0489	protein tyrosine kinase activity
ATC04_06860	COG2151	metal-sulfur cluster biosynthetic enzyme
ATC04_06870	COG2239	Acts as a magnesium transporter
ATC04_06880	COG0006	proline dipeptidase activity
ATC04_06890	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ATC04_06900	COG0557	exoribonuclease II activity
ATC04_06910	COG1309	transcriptional regulator
ATC04_06915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ATC04_06920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ATC04_06940	COG0181	hydroxymethylbilane synthase activity
ATC04_06950	COG0113	porphobilinogen synthase activity
ATC04_06955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ATC04_06960	COG0531	amino acid
ATC04_06965	COG1464	Belongs to the NlpA lipoprotein family
ATC04_06970	COG2011	ABC-type metal ion transport system permease component
ATC04_06975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ATC04_07025	COG3480	Lon protease (S16) C-terminal proteolytic domain
ATC04_07030	COG1615	UPF0182 protein
ATC04_07060	COG1842	Phage shock protein A
ATC04_07070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ATC04_07080	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ATC04_07095	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ATC04_07115	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ATC04_07130	COG0482	sulfurtransferase activity
ATC04_07160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ATC04_07175	COG4533	DNA binding
ATC04_07180	COG0601	transmembrane transport
ATC04_07185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ATC04_07190	COG4172	Belongs to the ABC transporter superfamily
ATC04_07205	COG0745	RESPONSE REGULATOR receiver
ATC04_07210	COG5002	protein histidine kinase activity
ATC04_07215	COG5401	PFAM Sporulation and spore germination
ATC04_07220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ATC04_07225	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ATC04_07230	COG3214	Protein conserved in bacteria
ATC04_07235	COG0653	protein targeting
ATC04_07265	COG2902	Dehydrogenase
ATC04_07275	COG1388	LysM domain
ATC04_07275	COG3942	CHAP domain
ATC04_07300	COG2001	Belongs to the MraZ family
ATC04_07305	COG0275	rRNA processing
ATC04_07330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ATC04_07335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ATC04_07340	COG0772	Belongs to the SEDS family
ATC04_07345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ATC04_07350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ATC04_07355	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ATC04_07360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ATC04_07370	COG1799	cell septum assembly
ATC04_07385	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ATC04_07395	COG0587	DNA-directed DNA polymerase activity
ATC04_07400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ATC04_07405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ATC04_07420	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ATC04_07425	COG0174	glutamine synthetase
ATC04_07430	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ATC04_07440	COG0590	tRNA wobble adenosine to inosine editing
ATC04_07450	COG0174	glutamine synthetase
ATC04_07465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ATC04_07470	COG0321	lipoyl(octanoyl) transferase activity
ATC04_07485	COG0508	dehydrogenase complex catalyzes the overall conversion of
ATC04_07490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ATC04_07495	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ATC04_07515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ATC04_07520	COG0187	DNA topoisomerase II activity
ATC04_07535	COG1271	oxidase subunit
ATC04_07540	COG1294	oxidase, subunit
ATC04_07545	COG4988	ABC transporter
ATC04_07550	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ATC04_07555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ATC04_07555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ATC04_07585	COG0756	dUTP diphosphatase activity
ATC04_07610	COG0569	domain protein
ATC04_07615	COG0531	amino acid
ATC04_07625	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ATC04_07670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ATC04_07675	COG3557	Belongs to the UPF0374 family
ATC04_07700	COG0137	argininosuccinate synthase activity
ATC04_07705	COG0667	Aldo Keto reductase
ATC04_07720	COG1024	Enoyl-CoA hydratase
ATC04_07720	COG1250	3-hydroxyacyl-CoA dehydrogenase
ATC04_07725	COG0183	Belongs to the thiolase family
ATC04_07755	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ATC04_07765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ATC04_07785	COG3135	benzoate transporter
ATC04_07835	COG0242	peptide deformylase activity
ATC04_07840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ATC04_07850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ATC04_07870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ATC04_07870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ATC04_07875	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ATC04_07880	COG0140	phosphoribosyl-ATP diphosphatase activity
ATC04_07885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ATC04_07890	COG0107	imidazoleglycerol-phosphate synthase activity
ATC04_07900	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ATC04_07920	COG0134	indole-3-glycerol-phosphate synthase activity
ATC04_07925	COG0133	tryptophan synthase activity
ATC04_07930	COG0159	tryptophan synthase activity
ATC04_07935	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ATC04_07940	COG0067	glutamate synthase
ATC04_07940	COG0069	glutamate synthase activity
ATC04_07940	COG0070	glutamate synthase
ATC04_07950	COG0469	pyruvate kinase activity
ATC04_07980	COG2050	protein possibly involved in aromatic compounds catabolism
ATC04_08000	COG0539	negative regulation of cytoplasmic translation
ATC04_08025	COG1739	Uncharacterized protein family UPF0029
ATC04_08035	COG0237	dephospho-CoA kinase activity
ATC04_08060	COG0556	nucleotide-excision repair
ATC04_08065	COG0861	Integral membrane protein TerC family
ATC04_08070	COG1846	Transcriptional regulator
ATC04_08125	COG4106	trans-aconitate 2-methyltransferase activity
ATC04_08145	COG3220	belongs to the UPF0276 family
ATC04_08170	COG0546	phosphoglycolate phosphatase activity
ATC04_08180	COG0322	excinuclease ABC activity
ATC04_08185	COG1660	Displays ATPase and GTPase activities
ATC04_08190	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ATC04_08195	COG1481	regulation of sporulation
ATC04_08210	COG0126	phosphoglycerate kinase activity
ATC04_08215	COG0149	triose-phosphate isomerase activity
ATC04_08220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ATC04_08230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ATC04_08255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ATC04_08265	COG0109	protoheme IX farnesyltransferase activity
ATC04_08310	COG0396	ATPase activity
ATC04_08315	COG2151	metal-sulfur cluster biosynthetic enzyme
ATC04_08320	COG2151	metal-sulfur cluster biosynthetic enzyme
ATC04_08330	COG0318	PFAM AMP-dependent synthetase and ligase
ATC04_08335	COG1268	BioY protein
ATC04_08340	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ATC04_08345	COG1122	ATPase activity
ATC04_08350	COG1280	lysine exporter protein (LysE YggA)
ATC04_08355	COG1522	sequence-specific DNA binding
ATC04_08360	COG0738	Major facilitator superfamily
ATC04_08400	COG1946	Acyl-CoA thioesterase
ATC04_08425	COG0698	ribose 5-phosphate isomerase
ATC04_08450	COG0544	peptidyl-prolyl cis-trans isomerase activity
ATC04_08460	COG0740	serine-type endopeptidase activity
ATC04_08465	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ATC04_08470	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ATC04_08480	COG0525	valine-tRNA ligase activity
ATC04_08505	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ATC04_08510	COG0175	sulfate reduction
ATC04_08550	COG2176	DNA-directed DNA polymerase activity
ATC04_08565	COG2409	Drug exporters of the RND superfamily
ATC04_08570	COG2197	response regulator
ATC04_08575	COG4585	Histidine kinase
ATC04_08590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ATC04_08595	COG0285	dihydrofolate synthase activity
ATC04_08605	COG0105	UTP biosynthetic process
ATC04_08640	COG1530	ribonuclease E activity
ATC04_08645	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ATC04_08650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ATC04_08655	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ATC04_08660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ATC04_08665	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ATC04_08675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ATC04_08685	COG0799	negative regulation of ribosome biogenesis
ATC04_08745	COG1113	amino acid transport
ATC04_08750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ATC04_08760	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_08775	COG0583	DNA-binding transcription factor activity
ATC04_08780	COG1053	succinate dehydrogenase
ATC04_08790	COG0488	(ABC) transporter
ATC04_08810	COG1250	3-hydroxyacyl-CoA dehydrogenase
ATC04_08825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ATC04_08835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ATC04_08840	COG0028	Belongs to the TPP enzyme family
ATC04_08845	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ATC04_08855	COG1780	Probably involved in ribonucleotide reductase function
ATC04_08860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ATC04_08865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ATC04_08870	COG0574	Belongs to the PEP-utilizing enzyme family
ATC04_08870	COG3848	Pyruvate phosphate dikinase
ATC04_08880	COG2814	Major facilitator Superfamily
ATC04_08920	COG2135	peptidase activity
ATC04_08930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ATC04_08945	COG0477	Major facilitator Superfamily
ATC04_08965	COG0587	DNA-directed DNA polymerase activity
ATC04_08995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ATC04_09005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ATC04_09010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ATC04_09015	COG0156	8-amino-7-oxononanoate synthase activity
ATC04_09035	COG1131	(ABC) transporter
ATC04_09045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ATC04_09050	COG1349	DNA-binding transcription factor activity
ATC04_09060	COG0395	ABC-type sugar transport system, permease component
ATC04_09065	COG1653	transport
ATC04_09070	COG0584	glycerophosphoryl diester phosphodiesterase
ATC04_09075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ATC04_09090	COG0456	acetyltransferase
ATC04_09095	COG0339	signal peptide processing
ATC04_09105	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ATC04_09110	COG0217	transcriptional regulatory protein
ATC04_09115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ATC04_09120	COG0632	four-way junction helicase activity
ATC04_09125	COG2255	four-way junction helicase activity
ATC04_09130	COG1862	Preprotein translocase
ATC04_09140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ATC04_09145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ATC04_09155	COG1196	nuclear chromosome segregation
ATC04_09160	COG0124	histidyl-tRNA synthetase
ATC04_09165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ATC04_09180	COG1490	D-aminoacyl-tRNA deacylase activity
ATC04_09190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ATC04_09205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ATC04_09210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ATC04_09220	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ATC04_09225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ATC04_09230	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ATC04_09235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ATC04_09245	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ATC04_09250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ATC04_09255	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ATC04_09260	COG0540	Belongs to the ATCase OTCase family
ATC04_09265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ATC04_09275	COG0505	Belongs to the CarA family
ATC04_09280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ATC04_09285	COG0284	orotidine-5'-phosphate decarboxylase activity
ATC04_09295	COG0194	GDP metabolic process
ATC04_09300	COG1758	RNA polymerase activity
ATC04_09310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ATC04_09335	COG2390	Transcriptional regulator
ATC04_09345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ATC04_09350	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ATC04_09365	COG0495	leucyl-tRNA aminoacylation
ATC04_09370	COG1307	EDD domain protein, DegV family
ATC04_09380	COG0658	competence protein
ATC04_09380	COG2333	competence protein COMEC
ATC04_09390	COG0268	Binds directly to 16S ribosomal RNA
ATC04_09400	COG0481	GTPase activity
ATC04_09420	COG1420	regulation of RNA biosynthetic process
ATC04_09425	COG0484	heat shock protein binding
ATC04_09430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ATC04_09445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ATC04_09455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ATC04_09465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ATC04_09470	COG1381	Involved in DNA repair and RecF pathway recombination
ATC04_09475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ATC04_09480	COG2267	carboxylic ester hydrolase activity
ATC04_09485	COG0167	dihydroorotate dehydrogenase activity
ATC04_09505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ATC04_09510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ATC04_09530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ATC04_09535	COG0723	plastoquinol--plastocyanin reductase activity
ATC04_09540	COG2010	Cytochrome c
ATC04_09545	COG1845	cytochrome c oxidase, subunit III
ATC04_09550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ATC04_09580	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ATC04_09600	COG0242	peptide deformylase activity
ATC04_09605	COG2226	methyltransferase
ATC04_09625	COG1216	Glycosyl transferase, family 2
ATC04_09640	COG0805	protein transport
ATC04_09645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ATC04_09665	COG0545	Peptidyl-prolyl cis-trans isomerase
ATC04_09670	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ATC04_09680	COG4122	O-methyltransferase activity
ATC04_09685	COG1222	aaa ATPase
ATC04_09695	COG1994	Peptidase M50
ATC04_09695	COG0517	IMP dehydrogenase activity
ATC04_09700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ATC04_09710	COG0215	cysteine-tRNA ligase activity
ATC04_09715	COG1968	undecaprenyl-diphosphatase activity
ATC04_09735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ATC04_09745	COG2205	protein histidine kinase activity
ATC04_09750	COG0745	RESPONSE REGULATOR receiver
ATC04_09755	COG1914	H( )-stimulated, divalent metal cation uptake system
ATC04_09765	COG3976	FMN-binding domain protein
ATC04_09765	COG1053	succinate dehydrogenase
ATC04_09780	COG0438	transferase activity, transferring glycosyl groups
ATC04_09790	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_09860	COG0095	Lipoate-protein ligase
ATC04_09865	COG0604	alcohol dehydrogenase
ATC04_09870	COG0254	rRNA binding
ATC04_09940	COG1119	ATPase activity
ATC04_09970	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_09975	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_10000	COG0488	(ABC) transporter
ATC04_10050	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ATC04_10065	COG1476	TRANSCRIPTIONal
ATC04_10070	COG3321	synthase
ATC04_10070	COG0604	alcohol dehydrogenase
ATC04_10085	COG1960	acyl-CoA dehydrogenase activity
ATC04_10090	COG0242	peptide deformylase activity
ATC04_10130	COG3022	response to hydroperoxide
ATC04_10140	COG0346	lactoylglutathione lyase activity
ATC04_10145	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ATC04_10150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ATC04_10160	COG1045	serine acetyltransferase
ATC04_10170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ATC04_10190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ATC04_10195	COG2130	NADP-dependent
ATC04_10215	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ATC04_10225	COG2610	gluconate transmembrane transporter activity
ATC04_10230	COG3265	gluconokinase activity
ATC04_10235	COG2261	transglycosylase associated protein
ATC04_10245	COG1272	protein, Hemolysin III
ATC04_10250	COG3237	CsbD-like
ATC04_10280	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ATC04_10295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ATC04_10320	COG4974	Belongs to the 'phage' integrase family
ATC04_10330	COG0606	chelatase, subunit chli
ATC04_10335	COG0792	nuclease activity
ATC04_10345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ATC04_10350	COG0681	Belongs to the peptidase S26 family
ATC04_10365	COG0681	Belongs to the peptidase S26 family
ATC04_10370	COG0335	large ribosomal subunit rRNA binding
ATC04_10375	COG0336	Belongs to the RNA methyltransferase TrmD family
ATC04_10380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ATC04_10385	COG1837	Belongs to the UPF0109 family
ATC04_10390	COG0228	four-way junction DNA binding
ATC04_10395	COG1280	lysine exporter protein (LysE YggA)
ATC04_10425	COG2837	iron assimilation
ATC04_10430	COG0183	Belongs to the thiolase family
ATC04_10435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ATC04_10445	COG2514	catechol 2,3-dioxygenase activity
ATC04_10450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ATC04_10455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ATC04_10475	COG1196	nuclear chromosome segregation
ATC04_10475	COG0741	lytic transglycosylase activity
ATC04_10475	COG0739	heme binding
ATC04_10495	COG2094	Belongs to the DNA glycosylase MPG family
ATC04_10505	COG2755	lipolytic protein G-D-S-L family
ATC04_10505	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ATC04_10535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ATC04_10545	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ATC04_10565	COG1484	DNA-dependent DNA replication
ATC04_10580	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ATC04_10585	COG0438	transferase activity, transferring glycosyl groups
ATC04_10595	COG1215	transferase activity, transferring glycosyl groups
ATC04_10610	COG1316	TRANSCRIPTIONal
ATC04_10615	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ATC04_10620	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ATC04_10635	COG0742	ribosomal rna small subunit methyltransferase
ATC04_10645	COG1461	Dihydroxyacetone kinase
ATC04_10650	COG1316	TRANSCRIPTIONal
ATC04_10660	COG1181	Belongs to the D-alanine--D-alanine ligase family
ATC04_10665	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ATC04_10675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ATC04_10680	COG0066	3-isopropylmalate dehydratase activity
ATC04_10685	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ATC04_10695	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ATC04_10705	COG1162	GTPase activity
ATC04_10725	COG0546	phosphoglycolate phosphatase activity
ATC04_10730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ATC04_10735	COG0179	Fumarylacetoacetate (FAA) hydrolase
ATC04_10740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ATC04_10745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ATC04_10750	COG0473	3-isopropylmalate dehydrogenase activity
ATC04_10755	COG4585	Histidine kinase
ATC04_10760	COG2197	response regulator
ATC04_10770	COG1432	Conserved Protein
ATC04_10800	COG2801	Transposase and inactivated derivatives
ATC04_10815	COG2801	Transposase and inactivated derivatives
ATC04_10815	COG3415	Transposase
ATC04_10825	COG0438	transferase activity, transferring glycosyl groups
ATC04_10835	COG0489	protein tyrosine kinase activity
ATC04_10840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ATC04_10850	COG0438	transferase activity, transferring glycosyl groups
ATC04_10890	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ATC04_10895	COG2197	response regulator
ATC04_10960	COG2244	polysaccharide biosynthetic process
ATC04_10965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ATC04_10975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ATC04_10980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ATC04_10995	COG2197	response regulator
ATC04_11010	COG1088	dTDP-glucose 4,6-dehydratase activity
ATC04_11015	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ATC04_11030	COG2226	methyltransferase
ATC04_11035	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ATC04_11040	COG0440	acetolactate synthase activity
ATC04_11045	COG0028	Belongs to the TPP enzyme family
ATC04_11050	COG0129	dihydroxy-acid dehydratase activity
ATC04_11060	COG1215	transferase activity, transferring glycosyl groups
ATC04_11085	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ATC04_11130	COG0702	epimerase
ATC04_11135	COG1846	Transcriptional regulator
ATC04_11175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ATC04_11185	COG0579	oxidoreductase
ATC04_11200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ATC04_11220	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ATC04_11230	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ATC04_11235	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ATC04_11245	COG1987	bacterial-type flagellum assembly
ATC04_11250	COG1338	Plays a role in the flagellum-specific transport system
ATC04_11275	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ATC04_11290	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ATC04_11300	COG0791	NLP P60 protein
ATC04_11310	COG1157	protein secretion by the type III secretion system
ATC04_11325	COG1766	The M ring may be actively involved in energy transduction
ATC04_11335	COG1558	bacterial-type flagellum-dependent cell motility
ATC04_11340	COG1815	bacterial-type flagellum-dependent cell motility
ATC04_11355	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ATC04_11360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ATC04_11365	COG1191	sigma factor activity
ATC04_11375	COG1256	bacterial-type flagellum assembly
ATC04_11380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ATC04_11385	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ATC04_11395	COG1846	Transcriptional regulator
ATC04_11435	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ATC04_11460	COG0129	dihydroxy-acid dehydratase activity
ATC04_11480	COG1802	Transcriptional regulator
ATC04_11485	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_11500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ATC04_11510	COG0488	(ABC) transporter
ATC04_11525	COG0477	Major facilitator Superfamily
ATC04_11540	COG3833	ABC-type maltose transport systems, permease component
ATC04_11545	COG1175	transmembrane transport
ATC04_11555	COG0366	Alpha amylase catalytic
ATC04_11560	COG1609	Transcriptional regulator
ATC04_11580	COG0419	ATPase involved in DNA repair
ATC04_11585	COG0420	3'-5' exonuclease activity
ATC04_11600	COG2176	DNA-directed DNA polymerase activity
ATC04_11610	COG1131	(ABC) transporter
ATC04_11635	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ATC04_11640	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ATC04_11655	COG0302	gtp cyclohydrolase
ATC04_11670	COG1234	tRNA 3'-trailer cleavage
ATC04_11675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ATC04_11685	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ATC04_11690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ATC04_11695	COG1335	isochorismatase
ATC04_11710	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ATC04_11710	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ATC04_11760	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
ATC04_11775	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ATC04_11780	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ATC04_11785	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ATC04_11790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ATC04_11795	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ATC04_11800	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ATC04_11805	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ATC04_11810	COG0356	it plays a direct role in the translocation of protons across the membrane
ATC04_11820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ATC04_11825	COG0009	L-threonylcarbamoyladenylate synthase
ATC04_11835	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ATC04_11845	COG0083	homoserine kinase activity
ATC04_11850	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ATC04_11855	COG0460	homoserine dehydrogenase
ATC04_11860	COG0019	diaminopimelate decarboxylase activity
ATC04_11865	COG0018	arginyl-trna synthetase
ATC04_11875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ATC04_11875	COG1116	anion transmembrane transporter activity
ATC04_11890	COG1643	Atp-dependent helicase
ATC04_11895	COG0537	adenosine 5'-monophosphoramidase activity
ATC04_11905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ATC04_11930	COG1121	(ABC) transporter
ATC04_11935	COG1253	flavin adenine dinucleotide binding
ATC04_11940	COG1253	flavin adenine dinucleotide binding
ATC04_11945	COG0508	dehydrogenase complex catalyzes the overall conversion of
ATC04_11945	COG0567	Dehydrogenase, E1 component
ATC04_11960	COG1595	DNA-templated transcription, initiation
ATC04_11965	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ATC04_11975	COG0483	inositol monophosphate 1-phosphatase activity
ATC04_11980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ATC04_11980	COG1321	iron dependent repressor
ATC04_11985	COG0589	response to stress
ATC04_11990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ATC04_11995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ATC04_12005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ATC04_12010	COG0741	lytic transglycosylase activity
ATC04_12010	COG0739	heme binding
ATC04_12010	COG1196	nuclear chromosome segregation
ATC04_12015	COG2177	Part of the ABC transporter FtsEX involved in
ATC04_12020	COG2884	Cell division ATP-binding protein ftsE
ATC04_12025	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ATC04_12125	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ATC04_12145	COG0582	viral genome integration into host DNA
ATC04_12180	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ATC04_12200	COG1022	Amp-dependent synthetase and ligase
ATC04_12210	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ATC04_12215	COG1192	Involved in chromosome partitioning
ATC04_12235	COG1716	ATPase activity
ATC04_12240	COG3189	MarR family transcriptional regulator
ATC04_12250	COG0488	(ABC) transporter
ATC04_12260	COG0384	phenazine biosynthesis protein PhzF
ATC04_12270	COG1160	GTP binding
ATC04_12275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ATC04_12290	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ATC04_12310	COG1301	dicarboxylic acid transport
ATC04_12315	COG3290	protein histidine kinase activity
ATC04_12340	COG2079	MmgE PrpD family protein
ATC04_12345	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ATC04_12360	COG3655	Transcriptional regulator
ATC04_12365	COG0494	nUDIX hydrolase
ATC04_12370	COG4974	Belongs to the 'phage' integrase family
ATC04_12375	COG0494	nUDIX hydrolase
ATC04_12380	COG0504	CTP synthase activity
ATC04_12385	COG0497	DNA recombination
ATC04_12390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ATC04_12405	COG0647	UMP catabolic process
ATC04_12435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ATC04_12445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ATC04_12455	COG0165	Argininosuccinate lyase
ATC04_12465	COG1438	arginine binding
ATC04_12470	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ATC04_12475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ATC04_12480	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ATC04_12485	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ATC04_12490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ATC04_12525	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ATC04_12535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ATC04_12540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ATC04_12540	COG0072	phenylalanine-tRNA ligase activity
ATC04_12545	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ATC04_12555	COG0494	nUDIX hydrolase
ATC04_12560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ATC04_12565	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ATC04_12570	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ATC04_12575	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ATC04_12595	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ATC04_12600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ATC04_12605	COG0131	Imidazoleglycerol-phosphate dehydratase
ATC04_12610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ATC04_12620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ATC04_12635	COG2813	Specifically methylates the guanine in position
ATC04_12640	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ATC04_12645	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ATC04_12650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ATC04_12660	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ATC04_12675	COG1058	Belongs to the CinA family
ATC04_12675	COG1546	Belongs to the CinA family
ATC04_12685	COG1674	ftsk spoiiie
ATC04_12700	COG1174	glycine betaine transport
ATC04_12705	COG0517	IMP dehydrogenase activity
ATC04_12705	COG1125	glycine betaine transport
ATC04_12710	COG2314	TM2 domain
ATC04_12730	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ATC04_12735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ATC04_12750	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ATC04_12765	COG0612	Peptidase, M16
ATC04_12785	COG1063	alcohol dehydrogenase
ATC04_12810	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ATC04_12815	COG0477	Major facilitator Superfamily
ATC04_12820	COG0583	DNA-binding transcription factor activity
ATC04_12825	COG1053	succinate dehydrogenase
ATC04_12830	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ATC04_12845	COG1854	S-ribosylhomocysteine lyase activity
ATC04_12870	COG4325	translation initiation factor activity
ATC04_12885	COG1185	polyribonucleotide nucleotidyltransferase activity
ATC04_12895	COG2807	transmembrane transport
ATC04_12905	COG1414	Transcriptional regulator
ATC04_12915	COG2124	cytochrome p450
ATC04_12935	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_12945	COG4565	transcriptional regulatory protein
ATC04_12950	COG3290	protein histidine kinase activity
ATC04_12970	COG0589	response to stress
ATC04_12980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ATC04_12985	COG0318	PFAM AMP-dependent synthetase and ligase
ATC04_12990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ATC04_13005	COG1619	proteins homologs of microcin C7 resistance protein MccF
ATC04_13025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ATC04_13030	COG4106	trans-aconitate 2-methyltransferase activity
ATC04_13035	COG0196	riboflavin kinase activity
ATC04_13050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ATC04_13065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ATC04_13075	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ATC04_13095	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ATC04_13100	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ATC04_13105	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ATC04_13105	COG0481	GTPase activity
ATC04_13115	COG0779	Required for maturation of 30S ribosomal subunits
ATC04_13140	COG4585	Histidine kinase
ATC04_13145	COG2197	response regulator
ATC04_13155	COG0442	prolyl-tRNA aminoacylation
ATC04_13185	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ATC04_13205	COG0750	zinc metalloprotease
ATC04_13210	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ATC04_13215	COG1960	acyl-CoA dehydrogenase activity
ATC04_13235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ATC04_13255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ATC04_13260	COG0601	transmembrane transport
ATC04_13265	COG0747	negative chemotaxis
ATC04_13270	COG0508	dehydrogenase complex catalyzes the overall conversion of
ATC04_13275	COG0022	dehydrogenase e1 component
ATC04_13290	COG1215	transferase activity, transferring glycosyl groups
ATC04_13295	COG1181	Belongs to the D-alanine--D-alanine ligase family
ATC04_13300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ATC04_13305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ATC04_13315	COG3275	phosphorelay sensor kinase activity
ATC04_13320	COG3279	Response regulator of the LytR AlgR family
ATC04_13330	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ATC04_13340	COG0575	Belongs to the CDS family
ATC04_13345	COG0233	cytoplasmic translational termination
ATC04_13350	COG0528	UMP kinase activity
ATC04_13355	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ATC04_13360	COG0052	Belongs to the universal ribosomal protein uS2 family
ATC04_13375	COG0438	transferase activity, transferring glycosyl groups
ATC04_13395	COG0438	transferase activity, transferring glycosyl groups
ATC04_13410	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ATC04_13425	COG1695	Transcriptional regulator
ATC04_13460	COG0358	DNA primase activity
ATC04_13510	COG0423	glycine-tRNA ligase activity
ATC04_13515	COG2501	S4 domain
ATC04_13530	COG2755	lipolytic protein G-D-S-L family
ATC04_13535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ATC04_13540	COG2873	o-acetylhomoserine
ATC04_13570	COG1349	DNA-binding transcription factor activity
ATC04_13600	COG1105	Belongs to the carbohydrate kinase PfkB family
ATC04_13615	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ATC04_13620	COG1228	amidohydrolase
ATC04_13625	COG1228	amidohydrolase
ATC04_13630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ATC04_13640	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ATC04_13655	COG0395	ABC-type sugar transport system, permease component
ATC04_13660	COG1175	transmembrane transport
ATC04_13665	COG1653	transport
ATC04_13680	COG1063	alcohol dehydrogenase
ATC04_13690	COG0477	Major facilitator Superfamily
ATC04_13700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ATC04_13710	COG4608	Belongs to the ABC transporter superfamily
ATC04_13715	COG0444	Belongs to the ABC transporter superfamily
ATC04_13725	COG0601	transmembrane transport
ATC04_13730	COG0747	negative chemotaxis
ATC04_13750	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ATC04_13755	COG0154	amidase activity
ATC04_13760	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ATC04_13790	COG1472	Belongs to the glycosyl hydrolase 3 family
ATC04_13795	COG0363	glucosamine-6-phosphate deaminase activity
ATC04_13820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ATC04_13845	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_13845	COG3347	Dehydrogenase
ATC04_13850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ATC04_13865	COG2814	Major facilitator Superfamily
ATC04_13875	COG0346	lactoylglutathione lyase activity
ATC04_13880	COG0640	Transcriptional regulator
ATC04_13900	COG2409	Drug exporters of the RND superfamily
ATC04_13905	COG0424	maF-like protein
ATC04_13920	COG0754	glutathionylspermidine amidase activity
ATC04_13930	COG4770	biotin carboxylase activity
ATC04_13955	COG0477	Major facilitator Superfamily
ATC04_13970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ATC04_13975	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ATC04_14005	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ATC04_14010	COG0822	iron-sulfur transferase activity
ATC04_14025	COG0193	aminoacyl-tRNA hydrolase activity
ATC04_14030	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ATC04_14045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ATC04_14055	COG0488	(ABC) transporter
ATC04_14060	COG4335	DNA alkylation repair
ATC04_14095	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_14110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ATC04_14115	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ATC04_14120	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ATC04_14125	COG3583	domain protein
ATC04_14130	COG0084	hydrolase, TatD family'
ATC04_14135	COG0714	Associated with various cellular activities
ATC04_14160	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
ATC04_14220	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ATC04_14225	COG1316	TRANSCRIPTIONal
ATC04_14235	COG1494	fructose-1,6-bisphosphatase
ATC04_14250	COG0114	fumarate hydratase activity
ATC04_14275	COG0477	Major facilitator Superfamily
ATC04_14295	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ATC04_14300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ATC04_14305	COG1331	Highly conserved protein containing a thioredoxin domain
ATC04_14315	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ATC04_14325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ATC04_14330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ATC04_14360	COG2801	Transposase and inactivated derivatives
ATC04_14365	COG4974	Belongs to the 'phage' integrase family
ATC04_14400	COG0148	phosphopyruvate hydratase activity
ATC04_14415	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ATC04_14450	COG1744	ABC transporter substrate-binding protein PnrA-like
ATC04_14455	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ATC04_14455	COG1473	amidohydrolase
ATC04_14460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ATC04_14470	COG2009	succinate dehydrogenase
ATC04_14480	COG1053	succinate dehydrogenase
ATC04_14485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ATC04_14495	COG0180	Tryptophanyl-tRNA synthetase
ATC04_14500	COG0708	Exodeoxyribonuclease III
ATC04_14525	COG2197	response regulator
ATC04_14540	COG0477	Major facilitator Superfamily
ATC04_14590	COG0477	Major facilitator Superfamily
ATC04_14595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ATC04_14600	COG2072	flavoprotein involved in K transport
ATC04_14615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ATC04_14620	COG3708	Transcriptional regulator
ATC04_14620	COG2207	Transcriptional regulator
ATC04_14675	COG1295	ribonuclease BN
ATC04_14740	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ATC04_14760	COG2217	Heavy metal translocating P-type atpase
ATC04_14775	COG2132	Multicopper oxidase
ATC04_14800	COG0785	Cytochrome C biogenesis protein
ATC04_14805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ATC04_14810	COG4974	Belongs to the 'phage' integrase family
ATC04_14835	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_14845	COG1802	Transcriptional regulator
ATC04_14850	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ATC04_14860	COG2838	Isocitrate dehydrogenase
ATC04_14870	COG2814	Major facilitator Superfamily
ATC04_14880	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ATC04_14885	COG1984	allophanate hydrolase subunit 2
ATC04_14890	COG4770	biotin carboxylase activity
ATC04_14920	COG4336	lyase activity
ATC04_14925	COG1914	H( )-stimulated, divalent metal cation uptake system
ATC04_14930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ATC04_14935	COG0138	bifunctional purine biosynthesis protein purh
ATC04_14945	COG0477	Major facilitator Superfamily
ATC04_14985	COG3971	2-oxopent-4-enoate hydratase activity
ATC04_14995	COG3483	tryptophan 2,3-dioxygenase activity
ATC04_15005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ATC04_15010	COG1652	LysM domain
ATC04_15015	COG1295	ribonuclease BN
ATC04_15060	COG0577	efflux transmembrane transporter activity
ATC04_15065	COG0577	efflux transmembrane transporter activity
ATC04_15065	COG1136	(ABC) transporter
ATC04_15080	COG0519	Catalyzes the synthesis of GMP from XMP
ATC04_15105	COG1250	3-hydroxyacyl-CoA dehydrogenase
ATC04_15110	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_15115	COG1960	acyl-CoA dehydrogenase activity
ATC04_15120	COG2508	Transcriptional regulator
ATC04_15135	COG2814	Major facilitator Superfamily
ATC04_15140	COG1846	Transcriptional regulator
ATC04_15155	COG0028	Belongs to the TPP enzyme family
ATC04_15185	COG1396	sequence-specific DNA binding
ATC04_15210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ATC04_15225	COG0045	succinate-CoA ligase (ADP-forming) activity
ATC04_15265	COG0739	heme binding
ATC04_15270	COG1321	iron dependent repressor
ATC04_15285	COG1278	Cold shock
ATC04_15295	COG0745	RESPONSE REGULATOR receiver
ATC04_15300	COG2205	protein histidine kinase activity
ATC04_15320	COG0459	protein refolding
ATC04_15370	COG2354	Protein conserved in bacteria
ATC04_15395	COG3842	ATPase activity
ATC04_15435	COG0277	FAD linked oxidase domain protein
ATC04_15455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ATC04_15460	COG0215	cysteine-tRNA ligase activity
ATC04_15465	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ATC04_15465	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ATC04_15470	COG1329	Transcriptional regulator
ATC04_15485	COG5002	protein histidine kinase activity
ATC04_15500	COG0588	phosphoglycerate mutase activity
ATC04_15515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ATC04_15645	COG4974	Belongs to the 'phage' integrase family
ATC04_15650	COG0656	L-ascorbic acid biosynthetic process
ATC04_15690	COG1966	Carbon starvation protein
ATC04_15695	COG0604	alcohol dehydrogenase
ATC04_15710	COG1505	serine-type exopeptidase activity
ATC04_15725	COG0514	ATP-dependent DNA helicase (RecQ)
ATC04_15740	COG1959	2 iron, 2 sulfur cluster binding
ATC04_15745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ATC04_15745	COG1017	nitric oxide dioxygenase activity
ATC04_15750	COG0596	Alpha beta hydrolase
ATC04_15760	COG2814	Major facilitator Superfamily
ATC04_15765	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ATC04_15820	COG1511	domain protein
ATC04_15850	COG0745	RESPONSE REGULATOR receiver
ATC04_15855	COG2205	protein histidine kinase activity
ATC04_15860	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ATC04_15865	COG0590	tRNA wobble adenosine to inosine editing
ATC04_15905	COG1140	nitrate reductase beta subunit
ATC04_15930	COG0746	molybdenum cofactor guanylyltransferase activity
ATC04_15955	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ATC04_15965	COG2318	DinB family
ATC04_15970	COG2378	regulation of single-species biofilm formation
ATC04_15995	COG0315	cyclic pyranopterin monophosphate synthase activity
ATC04_16000	COG0521	Mo-molybdopterin cofactor biosynthetic process
ATC04_16000	COG0315	cyclic pyranopterin monophosphate synthase activity
ATC04_16005	COG0584	glycerophosphoryl diester phosphodiesterase
ATC04_16030	COG1414	Transcriptional regulator
ATC04_16035	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ATC04_16045	COG0183	Belongs to the thiolase family
ATC04_16050	COG2814	Major facilitator Superfamily
ATC04_16060	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
ATC04_16065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ATC04_16075	COG3485	protocatechuate 3,4-dioxygenase
ATC04_16080	COG3485	protocatechuate 3,4-dioxygenase
ATC04_16095	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ATC04_16135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ATC04_16140	COG0786	glutamate:sodium symporter activity
ATC04_16150	COG1414	Transcriptional regulator
ATC04_16155	COG0671	phosphoesterase, PA-phosphatase related
ATC04_16160	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ATC04_16165	COG1201	RNA secondary structure unwinding
ATC04_16170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ATC04_16175	COG0564	pseudouridine synthase activity
ATC04_16190	COG2814	Major facilitator Superfamily
ATC04_16205	COG0343	queuine tRNA-ribosyltransferase activity
ATC04_16215	COG4133	protoheme IX ABC transporter activity
ATC04_16240	COG0351	phosphomethylpyrimidine kinase
ATC04_16255	COG1472	Belongs to the glycosyl hydrolase 3 family
ATC04_16285	COG0778	Nitroreductase
ATC04_16290	COG4585	Histidine kinase
ATC04_16300	COG2197	response regulator
ATC04_16305	COG0542	response to heat
ATC04_16345	COG1476	TRANSCRIPTIONal
ATC04_16380	COG0406	alpha-ribazole phosphatase activity
ATC04_16415	COG0745	RESPONSE REGULATOR receiver
ATC04_16435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ATC04_16475	COG4565	transcriptional regulatory protein
ATC04_16480	COG3290	protein histidine kinase activity
ATC04_16485	COG2851	Citrate transporter
ATC04_16490	COG2318	DinB family
ATC04_16510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ATC04_16520	COG3012	SEC-C Motif Domain Protein
ATC04_16525	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ATC04_16530	COG0047	phosphoribosylformylglycinamidine synthase activity
ATC04_16535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ATC04_16550	COG2824	Alkylphosphonate utilization operon protein PhnA
ATC04_16605	COG2315	Protein conserved in bacteria
ATC04_16610	COG1832	CoA-binding protein
ATC04_16620	COG1960	acyl-CoA dehydrogenase activity
ATC04_16630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ATC04_16635	COG0601	transmembrane transport
ATC04_16650	COG0702	epimerase
ATC04_16670	COG0405	Gamma-glutamyltransferase
ATC04_16700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ATC04_16705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ATC04_16710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ATC04_16720	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ATC04_16725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ATC04_16725	COG2169	Transcriptional regulator
ATC04_16735	COG0406	alpha-ribazole phosphatase activity
ATC04_16745	COG1832	CoA-binding protein
ATC04_16750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ATC04_16755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ATC04_16760	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ATC04_16770	COG1349	DNA-binding transcription factor activity
ATC04_16775	COG1105	Belongs to the carbohydrate kinase PfkB family
ATC04_16780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ATC04_16780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ATC04_16780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ATC04_16785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ATC04_16800	COG0726	polysaccharide deacetylase
ATC04_16820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ATC04_16825	COG0028	Belongs to the TPP enzyme family
ATC04_16835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ATC04_16850	COG0697	spore germination
ATC04_16860	COG0583	DNA-binding transcription factor activity
ATC04_16870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ATC04_16885	COG0347	Belongs to the P(II) protein family
ATC04_16890	COG0004	ammonium transporteR
ATC04_16895	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ATC04_16915	COG1113	amino acid transport
ATC04_16925	COG1522	sequence-specific DNA binding
ATC04_16935	COG5002	protein histidine kinase activity
ATC04_16940	COG0745	RESPONSE REGULATOR receiver
ATC04_16985	COG1674	ftsk spoiiie
ATC04_16990	COG0515	serine threonine protein kinase
ATC04_17005	COG0739	heme binding
ATC04_17010	COG0357	Ribosomal RNA small subunit methyltransferase G
ATC04_17010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ATC04_17025	COG1131	(ABC) transporter
ATC04_17040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ATC04_17050	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ATC04_17070	COG1960	acyl-CoA dehydrogenase activity
ATC04_17085	COG1024	Enoyl-CoA hydratase
ATC04_17135	COG2252	PERMEase
ATC04_17260	COG0277	FAD linked oxidase domain protein
ATC04_17280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ATC04_17295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ATC04_17300	COG1937	Protein conserved in bacteria
ATC04_17315	COG0824	Thioesterase
ATC04_17330	COG0596	Alpha beta hydrolase
ATC04_17365	COG2226	methyltransferase
ATC04_17370	COG0488	(ABC) transporter
ATC04_17420	COG0306	phosphate transporter
ATC04_17435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ATC04_17450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ATC04_17460	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ATC04_17465	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ATC04_17475	COG1194	a g-specific adenine glycosylase
ATC04_17485	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ATC04_17510	COG5632	N-Acetylmuramoyl-L-alanine amidase
ATC04_17510	COG3409	Peptidoglycan-binding domain 1 protein
ATC04_17750	COG5632	N-Acetylmuramoyl-L-alanine amidase
ATC04_17750	COG3409	Peptidoglycan-binding domain 1 protein
ATC04_17810	COG1192	Involved in chromosome partitioning
ATC04_17850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ATC04_17855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ATC04_17865	COG1937	Protein conserved in bacteria
ATC04_17880	COG1595	DNA-templated transcription, initiation
ATC04_17895	COG2856	Zn peptidase
ATC04_17910	COG4115	mRNA cleavage
ATC04_17915	COG2161	toxin-antitoxin pair type II binding
ATC04_17935	COG1595	DNA-templated transcription, initiation
ATC04_17955	COG0741	lytic transglycosylase activity
ATC04_17955	COG0739	heme binding
ATC04_17955	COG1196	nuclear chromosome segregation
ATC04_18045	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ATC04_18055	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ATC04_18110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ATC04_18115	COG1061	Type III restriction enzyme res subunit
ATC04_18120	COG1002	Type II restriction enzyme, methylase subunits
ATC04_18180	COG2261	transglycosylase associated protein
ATC04_18245	COG1192	Involved in chromosome partitioning
ATC04_18310	COG0741	lytic transglycosylase activity
ATC04_18310	COG0739	heme binding
ATC04_18310	COG1196	nuclear chromosome segregation
ATC04_18330	COG1454	alcohol dehydrogenase
ATC04_18385	COG1053	succinate dehydrogenase
ATC04_18390	COG4644	lycopene metabolic process
ATC04_18435	COG1192	Involved in chromosome partitioning
ATC04_18550	COG1196	nuclear chromosome segregation
ATC04_18550	COG0741	lytic transglycosylase activity
ATC04_18550	COG0739	heme binding
ATC04_18570	COG1454	alcohol dehydrogenase